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Andrew Robson, Marion McGilvary, Valerie Riches, Phil Yates, Raymond Snoddy Media Editor, Nick Nuttall Environment Correspondent, Ben MacIntyre and Ian Brodie, Helen Studd, Nick Nuttall, Oliver Holt Chief Sports Correspondent, Robert Cole, Andrew Pierce, Angela Mason, James Moore, Sarah Potter, Simon Barnes, Peter Lansley, Claire McDonald, Mark Souster, Martin Richards, Graham E. Livings, Michael Evans Defence Editor, Philip Howard, Harry Midwood, David Chater, Anna S?derblom and Ben Hammersley, Elizabeth Judge, Gabrielle Starkey, Gerald Davies, John O'Leary Education Editor, Michael St John Parker, Valerie Elliott Countryside Editor, David McVay, John le Carr?, Greg Hurst Parliamentary Correspondent and Mark Henderson Science Correspondent, Dominic Walsh, Gary Jacob, Henry Guly, Victoria Segal, Alix Ramsay Tennis Correspondent, Chalfont, Audrey Magee Ireland Correspondent, Tim Chambers, Aston Villa, Rodney Milnes, John le Carre, Fraser Nelson Scottish Political Correspondent, Keith Pike, Adams Sage, David Hands, Charles Bremner, Philip Webster and Martin Fletcher, Billy Elliot, Greg Hurst, Peter Barnard, Patience Wheatcroft Business Editor, Arthur Leathley City Correspondent, Angela Jameson, Jasper Gerard, Russell Kempson, Robert Cole City Correspondent, Daniel McGrory, Oliver Kay, Lisa Armstrong, Rick Broadbent, Sam Lister and Ben Webster, Matt Dickinson Football Correspondent, Christopher Martin-Jenkins, John Hopkins, Barry Millington, Rob Wright, Stephen Farrell and Zahid Hussain, David Powell Athletics Correspondent, Raymond Keene, Clive Mathieson, Sean MacAulay, Matt Dickinson, Christine Buckley Industrial Editor, Martin Fletcher and Philip Webster, Peter Bryan, Imogen Edwards-Jones, Chris Ayres Media Business Correspondent, Cathy Harris, Richard Owen, Alan A. Taylor, Helen Nugent, Damian Whitworth, Martin Woods, Oliver August, Nick Hasell, Bill MacCORMICK, David Hands Rugby Correspondent, Ben Hammersley, John Allison, Rolf Harris, William Rees-Mogg, Nick Szczepanik, John Goodbody, James Doran, Melissa Kite Political Correspondent, Alan Copps, Tim Hames, Craig Lord, Linus Gregoriadis, Kevin McCarra, Edward Gorman and Daniel McGrory, George Caulkin, Chris McGrath, Phil Gordon Scottish football, Tim Wapshott, Glen Owen Education Correspondent, Keith Blackmore, Rachel Bridge and Michael Evans Defence Editor, Walter Gammie, Peter Riddell, Ben MacIntyre, Mark Oakley, W. A. C. Halliwell, Fraser Nelson, Lea Paterson, Carl Mortished International Business Editor, Nigel Hawkes Health Editor, Jonathan Leigh, Daniel Rosenthal, Nigel Powell, Dr Thomas Stuttaford, Lindsay Nicolle, Alyson Rudd, Bill Edgar, Sam Kiley, Anne Bramley, David Powell, Arthur Leathley, Haydn Middleton, Timothy Russ, Edward Gorman Sailing Correspondent, Sally Patten Retail Correspondent, Christopher Irvine, Joanna Coles,

... Post Office prepares Far from disappearing under a welter of electronic communication, s local branches are fighting ...

2000 - Gale Group | TDA

Artigo Acesso aberto Revisado por pares

Anselm Loges, Marco Manni, Marion Louvel, Max Wilke, Sandro Jahn, Edmund Welter, Manuela Borchert, Shilei Qiao, Stephan Klemme, Bettina G. Keller, Timm John,

Zirconium and hafnium behave nearly identically in most geological processes due to their identical nominal ionic charge and similar radius. Some of the most pronounced exceptions from this rule are observed in fluoride-rich aqueous systems, suggesting that aqueous fluoride complexation may be involved in Zr/Hf fractionation. To understand the mechanisms causing this phenomenon, we investigated complexation of Zr4+ and Hf4+ in fluoride-rich (1.0 mol/kg HF) aqueous solutions at 40 MPa and 100 - 400 ° ...

Tópico(s): Inorganic Fluorides and Related Compounds

2023 - Elsevier BV | Geochimica et Cosmochimica Acta

Jornais Acesso aberto

Alexander Jackson, Juan Carlos Gumucio, Tom Pendry, Victoria Glendinning, Andrew Billen, P. G., Michael Binyon, Nashua, Nicholas Wood, Political Correspondent, Graham Kelly, Michael Rogers, Frank Johnson, Simon Barnes, John Ballantine La Jolla, Michael Dean, B. H. Owen, Gordon Allan, Ronald Faux, David Lee, Cliff Feltham, Sheridan Morley, William Walton, Michael Stevenson, Hilary Finch, Nuala Scarisbrick, Henry Plumb, Michael Binyon, Jeremy Kingston, Ludovic Kennedy, Liz Hodgkinson, Richard Evans, Media Editor, Carol Leonard, David Thurlow, Philip Middleton, Kenneth Mellanby, Alistair Hicks, Stuart Jones Football Correspondent, Mario Modiano, Kenneth Baker, Geoffrey Smith, Colin Narbrough, Roddy Forsyth, John Spicer, Employment Affairs Correspondent, Geoff Brown, Roger McSweeney, Joe Joseph, Bernard Levin, Howard Foster, Henry Gee, Christopher R. Hill, Sarah Thompson, Education Reporter, Michael Tate, Peter Ball, John Clare, Geoffrey Trease, Lawrence Lever, Rodney Cowton, Transport Correspondent, Thomson Prentice Science Correspondent, Peter Ackroyd, Michael Evans, Defence Correspondent, Alan Hamilton, Martin Fletcher, Political Reporter, John Young, David Barnes, Rex Bellamy, Barry Fantoni, Eric Harvey, Rex Bellamy, Tennis Correspondent, John Hennessy, Nicholas Serpell, Rasit Gurdilek, Dick Hinder, Paul Messham, Neil Kelly, Sydney Friskin, David Smith, Economics Correspondent, Dennis Signy, David Miller, Nigel Andrew, Mitchell Platts Golf Correspondent, (Michael Phillips), Christopher Goulding, Craig Seton and Stewart Tendler, Robin Oakley, Political Editor, Kerry Gill, David Robinson, Alan Lee, Cricket Correspondent, Craig Brown, Ken Gosling, Paul Griffiths, George F. Balfour, John Cooney, Alexandra Jackson, Craig Seton, Irving Wardle, Marcel Berlins, Ian Ross, Ronald Butt, Edmund L. de Rothschild, Sheila Gunn Political Staff, Derek Harris, Industrial Editor, Charles Knevitt, Architecture Correspondent, Rodney Hobson, David Hands Rugby Correspondent, David Brewerton, Keith Simpson, John Goodbody, Christopher Walker, Jill Sherman Social Services Correspondent, Iain MacLeod, Carol Ferguson, George Hill, Srikumar Sen Boxing Correspondent, Graham Searjeant Financial Editor, John Crossland, Sarah Jane Checkland Art Market Correspondent, David Gollob, Gillian Goodwin, J. M. R. Hagger, Richard Ford and John Cooney, Sarah Jane Checkland, Michael Clark and Geoffrey Foster, Philip Webster, Ian Stafford, Tim Jones, Bailey Morris, Dr Thomas Stuttaford, Peter Strafford, Derek Harris Industrial Editor, D. P. F. Wheatley, Susan MacDonald, Gillian Greenwood, Maggie Drummond, John H. Gibbs, Colin McQuillan, Andrew Mango, D. O. Edwards, Ivor Davis,

... advent of Valium. The Seventies passed in a welter of prescriptions, and now, it seems, the 'happy ...

1988 - Gale Group | TDA

Artigo Acesso aberto Revisado por pares

Stephan Klemme, M. Feldhaus, V. Potapkin, Max Wilke, Manuela Borchert, Marion Louvel, Anselm Loges, Arno Rohrbach, P. Weitkamp, Edmund Welter, Maria A. Kokh, Christian Schmidt, Denis Testemale,

We present a new autoclave that enables in situ characterization of hydrothermal fluids at high pressures and high temperatures at synchrotron x-ray radiation sources. The autoclave has been specifically designed to enable x-ray absorption spectroscopy in fluids with applications to mineral solubility and element speciation analysis in hydrothermal fluids in complex compositions. However, other applications, such as Raman spectroscopy, in high-pressure fluids are also possible with the autoclave. ...

Tópico(s): Geochemistry and Geologic Mapping

2021 - American Institute of Physics | Review of Scientific Instruments

Artigo Acesso aberto Revisado por pares

Shidi Wu, Marion Rietveld, Marieke Hogervorst, Frank de Gruijl, Sjoerd H. van der Burg, Maarten H. Vermeer, Remco van Doorn, Marij J.P. Welters, Abdoelwaheb El Ghalbzouri,

Human dermis can be morphologically divided into the upper papillary and lower reticular dermis. Previously, we demonstrated that papillary (PFs) and reticular (RFs) fibroblasts show distinct morphology and gene expression profiles. Moreover, they differently affect tumor invasion and epithelial-to-mesenchymal transition (EMT) in in vitro 3D-organotypic cultures of cutaneous squamous cell carcinoma (cSCC). In this study, we examined if these distinct effects of PFs and RFs can be extrapolated in other ...

Tópico(s): Immunotherapy and Immune Responses

2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences

Artigo

Obbina Abani, Amr E. Abbas, Fatima Abbas, Jonathan R. Abbas, Kaja Abbas, Mustafa Abbas, Sadia Abbasi, H Abbass, Anne L. Abbott, Nadine Abdallah, Ashraf Omar Abdelaziz, M Abdelfattah, Bushra Abdelqader, A Abdul, Basir Abdul, Sami Aftab Abdul, Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Abdullah Mohammed, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Abeer Ul Amna, Laurent Abel, Kathy Abernethy, Movin Abeywickrema, Chandra Abhinaya, Ahmad Farid Abidin, Adebanke Aboaba, Abigail Aboagye-Odei, Christopher Aboah, Heba Aboelela, H Abo-Leyah, Karim Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Ahmed Abousamra, M. Abouzaid, Mathew Abraham, Tizzy Abraham, A. Abraheem, J. Abrams, Richard Abrams, H.J. Abu, Ahmad Abu-Arafeh, S.M. Abubacker, Akata Abung, Yousef Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Faustina Acheampong, Paul Acheampong, Sarah Acheampong, James Acheson, Shiella Achieng, Andrés Acosta, Rebecca Acquah, Cindy Acton, Jacqueline Adabie-Ankrah, Pauline Adair, AS Adam, Fiona Adam, Matthew Adam, Huzaifa Adamali, M Adamczyk, Christopher Adams, David H. Adams, Katie Adams, Lisa C. Adams, Nicholas M. Adams, Richard Adams, Tempestt Adams, Laura Adamu-Ikeme, Krishma Adatia, Kim G. Adcock, Lawrence Addai-Boampong, A. Addo, Oluwafemi Adeagbo, Adewole Adebiyi, O. S. Adedeji, Yewande Adegeye, K Adegoke, Vicki Adell, Sherna Adenwalla, F.W. Adeoye, O.A. Adesemoye, E.O. Adewunmi, A Adeyanju, Joyce Adeyemi, Titilope A. Adeyemo, Bidur Adhikari, SA Adhikari, R Adhikary, A. Aditya, Patience Adjepong, Gabrielle Adkins, Ahmad Adnan, M Adriaanse, J. Aeron-Thomas, Debbie Affleck, Carmel Afnan, Muhammad Abdur Rahman Afridi, Patricia Afrim, FA Afriyie, Z.A. Aftab, Agnes Awuah, Mudit Agarwal, P.N. Agasiya, Rachel Agbeko, C Agbo, Sunil Aggarwal, A. Aghababaie, L A Aguilar Jimenez, J.A. Agyekum, Kwame Agyen, E.K. Ahadome, S Ahamed Sadiq, MH Ahammed Nazeer, Ahmad Mukhtar, Saad Ahmad, A. Ahmed, BAR Ahmed, Bilal Ahmed, Farhan Ahmed, Helal Uddin Ahmed, Irshad Ahmed, Kawsar Ahmed, L Ahmed, Muhammad S. Ahmed, MC Ahmed, MS Ahmed, Nausheen Ahmed, Nausheen Ahmed, Osama Ahmed, Ahmed Ra, Rizwan Ahmed, Rizwan Ahmed, Sanam Ahmed, SG Ahmed, SH Ahmed, Rabeka A. Ali, Bilal A Mohamud, Sanam Ahmed, Sana Ahmer, Augustine Ahonia, Clement Aidoo, C Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, L. Aitken, B. Ajay, Abdulakeem Ajibode, Ahdi Noomen Ajmi, Nahid Akhtar, Suha Akili, Bolutito Akinbiyi, O Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Muhammad Akram, Olugbenro Aktinade, Uzayr Akudi, ASAR Al Aaraj, Ali Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, A Alabi, Narendra Aladangady, Mahmoud Alafifi, AHM Khurshid Alam, Md. Samrat Alam, A Al-Asadi, Kyriaki S. Alatzoglou, Paul Albert, A. Albertus, Lorraine Albon, Antonio Luna, Gemma Alcorn, Stephen Alcorn, Andrés Gómez-Aldana, David Alderdice, Abdullah Aldesouki, Rayan Aldouri, Jonathan Aldridge, N. Aldridge, R. H. Good Ale, Ana Alegria, Amit Alexander, Craig J. Alexander, John H. Alexander, PDG Alexander, Julyan Al-Fori, Laith Alghazawi, Osama Alhabsha, Bahij Al-Hakim, R Alhameed, M Al-Hayali, Shams Al‐Hity, Ala Ali, FR Ali, Johar Ali, Mohammad Ali, MS Ali, Nayab Ali, Omar Hasan Ali, R Ali, Syed Ahsan Ali, Emilio Aliberti, J Alin, Abid Alina, Analyn Alipustain, Bachti Alisjahbana, Fine Aliyuda, Kaveh Alizadeh, Maithem Al-Jibury, Saja Al-Juboori, Mohammad Ali, A. Alkhudhayri, Moutaz Alkhusheh, Frank N. Allan, Nicholas P. Allan, Alison Allanson, Robert Allcock, Emma Allen, Jason W. Allen, Keeley Allen, Louise Allen, Pamela B. Allen, R J Allen, Stephen Allen, Tammy D. Allen, Abiola Alli, Kelly C. Allison, Brent E. Allman, H.K. Allsop, Lynne Allsop, David Allsup, A.F.T. Almahroos, Hassan Al-Moasseb, M. Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Z. Al-Saadi, Riyam Al-Sammarraie, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, F Alsheikh, Bashar Al‐Sheklly, Sana Altaf, A Alty, Míriam J. Álvarez, Maria Alvarez Corral, Edward Alveyn, Maysaa Alzetani, Susan Amamou, N Amar, S Ambalavanan, Robert Ambrogetti, Christopher S. Ambrose, A Ameen, Amel Amelia Ganefianty, Katharine Ames, M. R. Amezaga, A. Amin, A. Amin, Kawa Amin, S Amin, Tarek Tawfik Amin, B Amit, Awais Amjad, Nasser Mohammad Amjad, James Amoah-Dankwa, Amos Amoako-Adusei, Victoria Amosun, Mochammad Fariz Amsal, Khaled Amsha, John Amuasi, Noelia Martín, Pugh Amy, Ann Anada, Atul Anand, Samantha Anandappa, S.D. Anantapatnaikuni, N.K.N. Andari, Élizabeth Anderson, Jennifer Anderson,

BackgroundEmpagliflozin has been proposed as a treatment for COVID-19 on the basis of its anti-inflammatory, metabolic, and haemodynamic effects. The RECOVERY trial aimed to assess its safety and efficacy in patients admitted to hospital with COVID-19.MethodsIn the randomised, controlled, open-label RECOVERY trial, several possible treatments are compared with usual care in patients hospitalised with COVID-19. In this analysis, we assess eligible and consenting adults who were randomly allocated ...

Elsevier BV

Revisão

Obbina Abani, Ali Abbas, Fatima Abbas, Joshua Abbas, Kasim Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Alison Abbott, Nabeel Abdallah, Ammar Abdelaziz, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, A Abdul, Basir Abdul, Siddiqui Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Abdullah Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Ul Amna Abeer Ul Amna, Lynn Abel, Katrina Abernethy, Movin Abeywickrema, Chandra Abhinaya, Affyarsyah Abidin, Adebanke Aboaba, Abigail Aboagye-Odei, Heba Aboelela, Hani Abo-Leyah, Karim Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Ahmed Abousamra, Mona Abouzaid, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Rebecca Abrams, Hyacinth-John Abu, Ahmed Abu-Arafeh, Syed M Abubacker, Akata Abung, Yousuf Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Prince Acheampong, Sarah Acheampong, Janet Acheson, Shiella Achieng, Andrés Acosta, Rebecca Acquah, Catherine Acton, Jacqueline Adabie-Ankrah, Paul Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Marta Adamczyk, Carol Adams, Charlotte Adams, Daniel Adams, Kate Adams, Laura Adams, Nikkita Adams, Richard Adams, Tim Adams, Laura Adamu-Ikeme, Krishma Adatia, Kirsty Adcock, Afua Addo, Oluwatobi Adeagbo, Ade Adebiyi, Ogunlana Adedeji, Yewande Adegeye, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Femi W Adeoye, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Adedamola Adeyanju, Joyce Adeyemi, Tenifayo Adeyemo, Binay Adhikari, Rina Adhikary, Adhikarla Aditya, Gabrielle Adkins, Adnan Adnan, John Aeron‐Thomas, Debbie Affleck, Carmel Afnan, Muhammad Abdur Rahman Afridi, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, L A Aguilar Jimenez, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, M. Ridwan Said Ahmad, Syed A. Ahmad, Afshan Ahmed, Ashar Ahmed, Asim Ahmed, Basheer A R Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Hanad Ahmed, Irshad Ahmed, Khaled Ahmed, Khalil Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rawya Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sana Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Bilal A Mohamud, Sana Ahmed, Sana Ahmer, Augustine Ahonia, C Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Bolutito Akinbiyi, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Mohammad Akram, Olugbenro Aktinade, Uzayr Akudi, Ahmad S A R Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Adegoke Alabi, Narendra Aladangady, Mohamed Alafifi, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki S. Alatzoglou, Paul Albert, Lorraine Albon, Angela Alcala, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Abdullah Aldesouki, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ram Maya Ale, Ana Alegria, Alison Alexander, Courtney Alexander, John H. Alexander, Peter Alexander, Julyan Al-Fori, Laith Alghazawi, Osama Alhabsha, Bahij Al-Hakim, Rafil Alhameed, Mohammed Al-Hayali, Shams Al‐Hity, Ali Ali, Amanda Ali, Asad Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohamed M. Ali, Mohammad Ali, Muhammad Ali, Nayab Ali, Oudai Ali, Ramla Ali, Sakina Ali, Irfan Syed, Emilio Aliberti, J Alin, Abid Alina, Analyn Alipustain, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, A. Alkhudhayri, Moutaz Alkhusheh, Fiona Allan, Nataliya Allan, Alison Allanson, Robert Allcock, Eireann Allen, Jade Allen, Kerry Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Tania Allen, Abiola Alli, Kathryn Allison, Bethan Allman, Helen K Allsop, Lynne Allsop, David Allsup, Amal Almahroos, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Riyam Al-Sammarraie, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Fadia Alsheikh, Bashar Al‐Sheklly, Sara Altaf, Amanda Alty, Mary Alvarez, Maria Alvarez Corral, Edward Alveyn, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Katharine Ames, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Badshah Amit, Amjad Amjad, Neelma Amjad, Victoria Amosun, Muhammad Amsal, Khaled Amsha, Noelia Martín, Pugh Amy, Ann Anada, Atul Anand, Samantha Anandappa, Satya D Anantapatnaikuni, Ellen Anderson, Julie Anderson, Laura Anderson, Marina Anderson, Michelle A. Anderson, Nicola Anderson, Rachel Anderson,

BackgroundWe aimed to evaluate the use of baricitinib, a Janus kinase (JAK) 1–2 inhibitor, for the treatment of patients admitted to hospital with COVID-19.MethodsThis randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple possible treatments in patients hospitalised with COVID-19 in the UK. Eligible and consenting patients were randomly allocated (1:1) to either usual standard of care alone (usual care group) or usual care plus ...

Elsevier BV

Artigo

Obbina Abani, Ali Abbas, Fatima Abbas, Joshua Abbas, Kasim Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Alison Abbott, Nabeel Abdallah, Ammar Abdelaziz, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, A Abdul, Basir Abdul, Siddiqui Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Abdullah Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Abeer Ul Amna, Lynn Abel, Katrina Abernethy, Movin Abeywickrema, Chandra Abhinaya, Affyarsyah Abidin, Adebanke Aboaba, Abigail Aboagye-Odei, Christopher Aboah, Heba Aboelela, Hani Abo-Leyah, Karim Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Ahmed Abousamra, Mona Abouzaid, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, J. Abrams, Rebecca Abrams, Hyacinth-John Abu, Ahmed Abu-Arafeh, Syed M Abubacker, Akata Abung, Yousuf Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Faustina Acheampong, Prince Acheampong, Sarah Acheampong, Janet Acheson, Shiella Achieng, Andrés Acosta, Rebecca Acquah, Catherine Acton, Jacqueline Adabie-Ankrah, Paul Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Marta Adamczyk, Carol Adams, Charlotte Adams, Daniel Adams, Kate Adams, Laura Adams, Nikkita Adams, Richard Adams, Tim Adams, Laura Adamu-Ikeme, Krishma Adatia, Kirsty Adcock, Lawrence Addai-Boampong, Afua Addo, Oluwatobi Adeagbo, Ade Adebiyi, Ogunlana Adedeji, Yewande Adegeye, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Femi W Adeoye, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Adedamola Adeyanju, Joyce Adeyemi, Tenifayo Adeyemo, Binay Adhikari, Shanti A Adhikari, Rina Adhikary, Adhikarla Aditya, Patience Adjepong, Gabrielle Adkins, Adnan Adnan, Marguerite Adriaanse, John Aeron‐Thomas, Debbie Affleck, Carmel Afnan, Muhammad Iqbal Afridi, Patricia Afrim, Felicia Akua Afriyie, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, L A Aguilar Jimenez, Jacqueline Afrakomah Agyekum, Kwame Agyen, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Mohammad Ahmad, Syed A. Ahmad, Afshan Ahmed, Ashar Ahmed, Asim Ahmed, Basheer A R Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Hanad Ahmed, Irshad Ahmed, Khaled Ahmed, Khalil Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rawya Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sana Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Bilal A Mohamud, Sana Ahmed, Sana Ahmer, Augustine Ahonia, C Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Bolutito Akinbiyi, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Mohammad Akram, Olugbenro Aktinade, Uzayr Akudi, Ahmad S A R Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Adegoke Alabi, Narendra Aladangady, Mohamed Alafifi, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki S. Alatzoglou, Paul Albert, Albertus Albertus, Lorraine Albon, Angela Alcala, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Abdullah Aldesouki, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ram Maya Ale, Ana Alegria, Alison Alexander, Courtney Alexander, John H. Alexander, Peter Alexander, Julyan Al-Fori, Laith Alghazawi, Osama Alhabsha, Bahij Al-Hakim, Rafil Alhameed, Mohammed Al-Hayali, Shams Al‐Hity, Ali Ali, Amanda Ali, Ali Asad, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohamed M. Ali, Mohammad Ali, Muhammad Ali, Nayab Ali, Oudai Ali, Ramla Ali, Sakina Ali, Syed Ahsan Ali, Emilio Aliberti, J Alin, Abid Alina, Analyn Alipustain, Bachti Alisjahbana, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, A. Alkhudhayri, Moutaz Alkhusheh, Fiona Allan, Nataliya Allan, Alison Allanson, Robert Allcock, Eireann Allen, Jade Allen, Kerry Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Tania Allen, Abiola Alli, Kathryn Allison, Bethan Allman, Helen K Allsop, Lynne Allsop, David Allsup, Amal Almahroos, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Riyam Al-Sammarraie, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Fadia Alsheikh, Bashar Al‐Sheklly, Sara Altaf, Amanda Alty, Mary Alvarez, Maria Alvarez Corral, Edward Alveyn, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Amel Amelia Ganefianty, Katharine Ames, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Badshah Amit, Amjad Amjad, Neelma Amjad, James Amoah-Dankwa, Victoria Amosun, Muhammad Amsal,

BackgroundLow-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group.MethodsThis randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised ...

Elsevier BV

Artigo

Simin Aysel Florescu, Dragos Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Komal Fareed, Aneela Kidwai, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, David Sapsford, Katherine Bongaerts, Peter J Featherstone, Anthony Ng, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, Adrian Donnelly, Martin Kelly, Naoise Smyth, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Géri, Antoine Vieillard-Baron, Paul D. R. Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C. Vignesh, Nagarajan Ramakrishnan, Augustian James, Evangeline Elvira, Pratheema Ramachandran, Suresh Babu, Rabindrarajan Ebenezer, Sarayu Krishnamoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Simone Piva, Emanuele Focà, Damiano Rizzoni, Gianluca E.M. Boari, Mattia Marchesi, Magdalena Butler, Keri-Anne Cowdrey, Brittany L. Mason, Melissa Woolett, Eamon Duffy, Yan Chen, Hiromi Nakamuro, Caroline O’Connor, Lauren West, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Manoj Saxena, Margaret Muteithia, Kelsey Dobell‐Brown, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick J. Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kate A. Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Emmet Major, Julie McAuley, Angus Carter, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Latesh Poojara, Treena Sara, Kiran Nand, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Marion Campbell, Filipa Santos, Dan Hansen, Dee Mullan, Julia Affleck, Arif Shaikh, Andrew Murray, Mahesh Ramanan, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Ritesh Sanghavi, Deepak Bhonagiri, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Bree McDonald, Natasha Edmunds, Oscar Hoiting, Marco Peters, Els Rengers, Manon Bindels, Mirjam Evers, Anton Prinssen, Morgan Matt, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, D. C. Law, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Adrien Auvet, Celine Ravry, Vanessa Creange, Anne-Hélène Boivin, Amélie Barreau, Sophie Vandewoestyne, Pierre-Louis Declercq, Antoine Marchalot, Cécile Saladin, Stéphanie Gelinotte, Jean-Pierre Eraldi, François Bourgerol, Marion Beuzelin, Rigaud Jean-Philippe, Franck Pourcine, Mehran Monchi, Gaël Pradel, Marie-Helene Hausermann, Michel Boudineau, Thi-My-Hue Nguyen-Valat, Christophe Guitton, Rémy Marnai, Marie-Hélène Leroyer, Michaël Landais, Cédric Darreau, Marjorie Saint Martin, Patrice Tirot, Nicolas Chudeau, Aurélie Brasselet, Lev Volkov, Jean-Christophe Callahan, Juliette Meunier, Thomas Douillard, Elliot Le Basnier, Marion Veillard, Dominique Vivier, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeur, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick D’Aragon, Dominique Bérard, Brian Grondin-Beaudoin, Marc-André Leclair, Olivier Lesur, Michaël Mayette, Yannick Poulin, Hector Quiroz-Martinez, Charles St-Arnaud, Élaine Carbonneau, Brigitte Bolduc, Julie Bélisle, Marie-Pier Bouchard, Line Côté, Joannie Martineau, Alexandra Naisby, Louise Robert-Petit, Marie-Ève Thibault, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, Aslanian Pierre, Sylvain Bélisle, François Martin Carrier, Emmanuel Charbonney, Martin Girard, Jean-Gilles Guimond, Antoine Halwagi, Christophe Kolan, Nicholas Robillard, Dounia Boumahni, Fatna Benettaib, M Cantin, Katherine Coutu-Beaudry, Ali Ghamraoui, F Lamothe, Martine Lebrasseur, Cindy Prié, Maya Salamé, Patrick Archambault, Émilie Côté, Rosalie Beaudoin, Monia Noël-Hunter, Mireille Boutin, Laurie Couture, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre-Yves Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel,

The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.

American Medical Association

Artigo

Simin Aysel Florescu, Dragos Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Komal Fareed, Aneela Kidwai, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, David Sapsford, Katherine Bongaerts, Peter J Featherstone, Anthony Ng, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, Adrian Donnelly, Martin Kelly, Naoise Smyth, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Géri, Antoine Vieillard‐Baron, Paul D. R. Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C. Vignesh, Nagarajan Ramakrishnan, Augustian James, Evangeline Elvira, Ramachandran Pratheema, Suresh Babu, Rabindrarajan Ebenezer, Sarayu Krishnamoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Simone Piva, Emanuele Focà, Damiano Rizzoni, Gianluca E.M. Boari, Mattia Marchesi, Magdalena Butler, Keri-Anne Cowdrey, Brittany L. Mason, Melissa Woolett, Eamon Duffy, Yan Chen, Hiromi Nakamuro, Caroline O’Connor, Lauren West, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Manoj Saxena, Margaret Muteithia, Kelsey Dobell‐Brown, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kathryn Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Emmet Major, Julie McAuley, Angus Carter, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Latesh Poojara, Treena Sara, Kiran Nand, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Marion Campbell, Filipa Santos, Dan Hansen, Dee Mullan, Julia Affleck, Arif Shaikh, Andrew Murray, Mahesh Ramanan, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Ritesh Sanghavi, Deepak Bhonagiri, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Bree McDonald, Natasha Edmunds, Oscar Hoiting, Marco Peters, Els Rengers, Manon Bindels, Mirjam Evers, Anton Prinssen, Matt Morgan, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, D. C. Law, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Adrien Auvet, Celine Ravry, Vanessa Creange, Anne-Hélène Boivin, Amélie Barreau, Sophie Vandewoestyne, Pierre-Louis Declercq, Antoine Marchalot, Cécile Saladin, Stéphanie Gelinotte, Jean-Pierre Eraldi, François Bourgerol, Marion Beuzelin, Rigaud Jean-Philippe, Franck Pourcine, Mehran Monchi, Gaël Pradel, Marie-Helene Hausermann, Michel Boudineau, Thi-My-Hue Nguyen-Valat, Christophe Guitton, Rémy Marnai, Marie-Hélène Leroyer, Michaël Landais, Cédric Darreau, Marjorie Saint Martin, Patrice Tirot, Nicolas Chudeau, Aurélie Brasselet, Lev Volkov, Jean-Christophe Callahan, Juliette Meunier, Thomas Douillard, Elliot Le Basnier, Marion Veillard, Dominique Vivier, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeur, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick D’Aragon, Dominique Bérard, Brian Grondin-Beaudoin, Marc-André Leclair, Olivier Lesur, Michaël Mayette, Yannick Poulin, Hector Quiroz-Martinez, Charles St-Arnaud, Élaine Carbonneau, Brigitte Bolduc, Julie Bélisle, Marie-Pier Bouchard, Line Côté, Joannie Martineau, Alexandra Naisby, Louise Robert-Petit, Marie-Ève Thibault, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, Aslanian Pierre, Sylvain Bélisle, François Martin Carrier, Emmanuel Charbonney, Martin Girard, Jean-Gilles Guimond, Antoine Halwagi, Christophe Kolan, Nicholas Robillard, Dounia Boumahni, Fatna Benettaib, M Cantin, Katherine Coutu-Beaudry, Ali Ghamraoui, F Lamothe, Martine Lebrasseur, Cindy Prié, Maya Salamé, Patrick Archambault, Émilie Côté, Rosalie Beaudoin, Monia Noël-Hunter, Mireille Boutin, Laurie Couture, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre-Yves Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel,

Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.

American Medical Association

Artigo

Obbina Abani, Ali Abbas, Fatima Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Nabeel Abdallah, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, D. Abdo, Basir Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Amina Abdulle, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Ul Amna Abeer Ul Amna, Katrina Abernethy, Adebanke Aboaba, Hani Abo-Leyah, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Hyacinth-John Abu, Ahmad Abu-Arafeh, Syed M Abubacker, Akata Abung, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Sarah Acheampong, Janet Acheson, Andrés Acosta, Catherine Acton, Jacqueline Adabie-Ankrah, Sara J. Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Carol Adams, Charlotte Adams, Kate Adams, Lisa C. Adams, Richard Adams, Tim Adams, Kirsty Adcock, Jemaimah Addai, Ade Adebiyi, Ken Adegoke, Vicki Adell, Debo Ademokun, Sherna Adenwalla, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Joyce Adeyemi, Rina Adhikary, Gabrielle Adkins, Adnan Adnan, John Aeron‐Thomas, Debbie Affleck, Dominic Affron, Carmel Afnan, Muhammad Abdur Rahman Afridi, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Penny Agent, Sunil Aggarwal, Arameh Aghababaie, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Humayun Ahmad, Mohammad Ahmad, Syed A. Ahmad, Asim A. Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Iram Ahmed, Irshad Ahmed, Khaled Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sara Ahmed, Sophia Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Sana Ahmed, Sana Ahmer, Dhiraj Ail, Mark Ainsworth, Giulia Airoldi, Myriam Aissa, Lindianne Aitken, Bini Ajay, Francis Ajeneye, Abdulakeem Ajibode, Ayesha Ajmi, Tahir Akbar, Naim Akhtar, Nasim Akhtar, Nauman Akhtar, Suha Akili, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Olajide Akinwumiju, Olugbenro Aktinade, Ahmad Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Narendra Aladangady, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Karina Al-Asadi, Kyriaki S. Alatzoglou, Manaf Al-Bayati, Paul Albert, Lorraine Albon, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ana Alegria, Alison Alexander, John H. Alexander, Peter Alexander, Charlotte Alford, Julyan Al-Fori, Laith Alghazawi, Bahij Al-Hakim, Shams Al‐Hity, Ali Ali, Asad Ali, Fawzia R Ali, Hoodo Ali, Jawad Ali, Mariam Ali, Mohammad Ali, Nayab Ali, Oudai Ali, Sabira Ali, Sakina Ali, Syed Ahsan Ali, Abid Alina, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Moutaz Alkhusheh, Allameddine Allameddine, Fiona Allan, Rachel Allan, Alison Allanson, Robert Allcock, B. Allen, Eireann Allen, Jess Allen, Kerry Allen, Laura K. Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Kathryn Allison, Bethan Allman, Lynne Allsop, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Bashar Al‐Sheklly, Sara Altaf, Mary Alvarez, Balaal Alyas, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Sarah-Jayne Ambler, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Kenneth Amenyah, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Amjad Amjad, Neelma Amjad, Mariam Ammoun, Victoria Amosun, Khaled Amsha, Pugh Amy, Atul Anand, Rekha Anand, Samantha Anandappa, Julie Anderson, Kevin L. Anderson, Laura Anderson, Michelle A. Anderson, Nicola Anderson, Rachel Anderson, Rory Anderson, Wendy G. Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Susan Andrews, Gregory Andrikopoulos, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Anu Varghese, Muhammad Naveed Anwar, George Apostolides, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Maia Aquino, Bianca Araba, Samuel Aransiola, Mariana E. G. de Araújo, Emily Arbon, Ann Archer, Denise Archer, Simon Archer, Christian Ardley, Ana-Maria Arias, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Sylvia Armstrong‐Fisher, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold,

BackgroundMany patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.MethodsThis randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. ...

Elsevier BV

Artigo

Obbina Abani, Ali Abbas, Fatima Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Nabeel Abdallah, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, Basir Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Abdullah Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Ul-Amna, Katrina Abernethy, Adebanke Aboaba, Hani Abo-Leyah, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Hyacinth-John Abu, Ahmad Abu-Arafeh, Syed M Abubacker, Akata Abung, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Sarah Acheampong, Janet Acheson, Andrés Acosta, Catherine Acton, Jacqueline Adabie-Ankrah, Fiona Adam, Matthew Adam, Huzaifa Adamali, Carol Adams, Charlotte Adams, Kate Adams, Richard Adams, Tim Adams, Krishma Adatia, Kirsty Adcock, Ade Adebiyi, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Joyce Adeyemi, Binay Adhikari, Rina Adhikary, Gabrielle Adkins, Adnan Adnan, John Aeron‐Thomas, Debbie Affleck, Carmel Afnan, Muhammad Abdur Rahman Afridi, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Mohammad Ahmad, Syed A. Ahmad, Asim A. Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Irshad Ahmed, Khaled Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Sana Ahmed, Sana Ahmer, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Olugbenro Aktinade, Ahmad S A R Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Narendra Aladangady, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki S. Alatzoglou, Paul Albert, Lorraine Albon, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ana Alegria, Alison Alexander, John H. Alexander, Peter Alexander, Julyan Al-Fori, Laith Alghazawi, Bahij Al-Hakim, Shams Al‐Hity, Ali Ali, Asad Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohammad Ali, Nayab Ali, Oudai Ali, Sakina Ali, Syed Ahsan Ali, Abid Alina, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Moutaz Alkhusheh, Fiona Allan, Alison Allanson, Robert Allcock, Eireann Allen, Kerry Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Kathryn Allison, Bethan Allman, Lynne Allsop, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Bashar Al‐Sheklly, Sara Altaf, Mary Alvarez, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Amjad Amjad, Neelma Amjad, Victoria Amosun, Khaled Amsha, Pugh Amy, Atul Anand, Samantha Anandappa, Julie Anderson, Laura Anderson, Michelle A. Anderson, Nicola Anderson, Rachel Anderson, Rory Anderson, Wendy G. Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, Louise Anning, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Anu Varghese, Muhammad Naveed Anwar, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Maia Aquino, Bianca Araba, Samuel Aransiola, Mariana E. G. de Araújo, Ann Archer, Denise Archer, Simon Archer, Christian Ardley, Ana-Maria Arias, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold, Dhawal Arora, Kavan Arora, Pardeep Arora, Rishi Arora, Arslam Arter, Ayush Arya, Rita Arya, Denisa Asandei, Adeeba Asghar, Catherine Ashbrook-Raby, Helen Ashby, Jan Ashcroft, John Ashcroft, Samuel Ashcroft, Georgia Asher, Ayesha Ashfaq, Abdul Ashish, Sally Ashman-Flavell, Ashok Raj, Abd-El-Aziz Ashour, Muhammad Ashraf, Saima Ashraf, Mohammad B Ashraq, Deborah Ashton, Susan Ashton, Andrew Ashworth, Rebecca Ashworth, Arshia Aslam, Harshini Asogan, Atif Asrar, Omar Assaf, Raine Astin-Chamberlain, Deborah Athorne, Billie Atkins,

BackgroundCasirivimab and imdevimab are non-competing monoclonal antibodies that bind to two different sites on the receptor binding domain of the SARS-CoV-2 spike glycoprotein, blocking viral entry into host cells. We aimed to evaluate the efficacy and safety of casirivimab and imdevimab administered in combination in patients admitted to hospital with COVID-19.MethodsRECOVERY is a randomised, controlled, open-label platform trial comparing several possible treatments with usual care in patients ...

Elsevier BV

Artigo

Simin Florescu, Delia Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Aneela Kidwai, Sobia Masood, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, János Bélteczki, István Magyar, Ágnes Fazekas, Sándor Kovács, Viktória Szőke, Adrian Donnelly, Martin Kelly, Naoise Smyth, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Geri, Antoine Vieillard-Baron, Paul Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C Vignesh, Bharath TV, N Ramakrishnan, Augustian James, Evangeline Elvira, Devachandran Jayakumar, Ramachandran Pratheema, Suresh Babu, R Ebenezer, S Krishnaoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Eileen Guilder, Magdalena Butler, Keri-Anne Cowdrey, Melissa Robertson, Farisha Ali, Ellie McMahon, Eamon Duffy, Yan Chen, Catherine Simmonds, Rachael McConnochie, Caroline O’Connor, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Manoj Saxena, Margaret Muteithia, Kelsey Dobell‐Brown, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick J. Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kate A. Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Cameron Knott, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Latesh Poojara, Treena Sara, Kiran Nand, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Julia Affleck, Arif Shaikh, Andrew Murray, Mahesh Ramanan, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Ritesh Sanghavi, Deepak Bhonagiri, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Bree McDonald, Natasha Edmunds, Oscar Hoiting, Marco Peters, Els Rengers, Mirjam Evers, Anton Prinssen, Matt Morgan, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Pierre Declerq, Antoine Marchalot, Stéphanie Gélinotte, Eraldi Jean-Pierre, Bourgerol François, Beuzelin Marion, Rigaud Philippe, Franck Pourcine, Mehran Monchi, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeu, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick D’Aragon, Élaine Carbonneau, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, François Martin Carrier, Dounia Boumahni, Fatna Benettaib, Ali Ghamraoui, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel, David Antcliffe, Maie Templeton, Roceld Rojo, Phoebe Coghlan, Joanna Smee, Gareth J. Barker, André Finn, Gabriele Kreb, Uwe Hoff, Carl Hinrichs, Jens Nee, Euan Mackay, Jon Cort, Amanda Whileman, Thomas E. Spencer, Nick Spittle, Sarah Beavis, Anand Padmakumar, Katie Dale, Joanne Hawes, Emma Moakes, Rachel Gascoyne, Kelly Pritchard, Lesley Stevenson, Justin Cooke, Karolina Nemeth-Roszpopa, Basanta Gauli, Sirjana Bastola, Grégoire Müller, Mai-Anh Nay, Toufik Kamel, Dalila Benzekri, Sophie Jacquier, Isabelle Runge, Armelle Mathonnet, François Barbier, Anne Bretagnol, Jay Carter, Kymbalee Van Der Heyden, Jan Mehrtens, Anna Morris, Stacey Morgan, Tara Burke, Emmanuelle Mercier, Delphine Chartier, Charlotte Salmon, Pierre‐François Dequin, Denis Garot, David Bellemare, Ève Cloutier, Rana Daher, Olivier Costerousse, Marie-Claude Boulanger, Émilie Couillard-Chénard, François Lauzier, Charles Francoeur, Bruno François, Alexandra Gay, Fedou Anne-Laure, Mohamed Ramali, Ooi HC, Alison Ghosh, Rawlings Osagie, Malka Arachchige, Melissa D. Hartley, Winston Cheung, Helen Wong, Patrick Seigne, Joe Eustace, Annmarie O’Callaghan, Fionnuala O'Brien,

The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.

American Medical Association

Artigo

Simin Florescu, Delia Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Aneela Kidwai, Sobia Masood, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, János Bélteczki, István Magyar, Ágnes Fazekas, Sándor Kovács, Viktória Szőke, Adrian Donnelly, Martin Kelly, Beverley J. Hunt, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Geri, Antoine Vieillard-Baron, Paul Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C Vignesh, Bharath TV, N Ramakrishnan, Augustian James, Evangeline Elvira, Devachandran Jayakumar, Pratheema Ramachandran, Suresh Babu, R Ebenezer, S Krishnaoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Eileen Guilder, Magdalena Butler, Keri-Anne Cowdrey, Melissa Robertson, Farisha Ali, Ellie McMahon, Eamon Duffy, Yan Chen, Catherine Simmonds, Rachael McConnochie, Caroline O’Connor, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kate A. Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Cameron Knott, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Julia Affleck, Yogesh Apte, Umesh Subbanna, Roland Bartholdy, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Karuna Keat, Deepak Bhonagiri, Ritesh Sanghavi, Jodie Nema, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Oscar Hoiting, Marco Peters, Els Rengers, Mirjam Evers, Anton Prinssen, Morgan Matt, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Pierre Declerq, Antoine Marchalot, Stéphanie Gélinotte, Eraldi Jean-Pierre, Bourgerol François, Beuzelin Marion, Rigaud Philippe, Franck Pourcine, Mehran Monchi, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeu, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick Carbonneau, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, François Martin Carrier, Dounia Boumahni, Fatna Benettaib, Ali Ghamraoui, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel, David Antcliffe, Maie Templeton, Roceld Rojo, Phoebe Coghlan, Joanna Smee, Gareth J. Barker, André Finn, Gabriele Kreß, Uwe Hoff, Carl Hinrichs, Jens Nee, Euan Mackay, Jon Cort, Amanda Whileman, Thomas E. Spencer, Nick Spittle, Sarah Beavis, Anand Padmakumar, Katie Dale, Joanne Hawes, Emma Moakes, Rachel Gascoyne, Kelly Pritchard, Lesley Stevenson, Justin Cooke, Karolina Nemeth-Roszpopa, Basanta Gauli, Sirjana Bastola, Grégoire Müller, Mai-Anh Nay, Toufik Kamel, Dalila Benzekri, Sophie Jacquier, Isabelle Runge, Armelle Mathonnet, François Barbier, Anne Bretagnol, Jay Carter, Kymbalee Van Der Heyden, Jan Mehrtens, Anna Morris, Stacey Morgan, Tara Burke, Emmanuelle Mercier, Delphine Chartier, Charlotte Salmon, Pierre‐François Dequin, Denis Garot, David Bellemare, Ève Cloutier, Rana Daher, Olivier Costerousse, Marie-Claude Boulanger, Émilie Couillard-Chénard, François Francoeur, Bruno François, Alexandra Gay, Fedou Anne-Laure, Mohamed Ramali, Ooi HC, Alison Ghosh, Rawlings Osagie, Malka Arachchige, Melissa D. Hartley, Winston Cheung, Mark Kol, Helen Wong, Asim A. Shah, Atul Wagh, Peter Bamford, Andrew Reid, Kathryn Cawley, Maria Faulkner, Charlotte Pickering, Ashok Raj, Georgios Tsinaslanidis, Reena Khade, Gloria Agha,

Importance The efficacy of antiplatelet therapy in critically ill patients with COVID-19 is uncertain. Objective To determine whether antiplatelet therapy improves outcomes for critically ill adults with COVID-19. Design, Setting, and Participants In an ongoing adaptive platform trial (REMAP-CAP) testing multiple interventions within multiple therapeutic domains, 1557 critically ill adult patients with COVID-19 were enrolled between October 30, 2020, and June 23, 2021, from 105 sites in 8 countries and followed ...

American Medical Association

Artigo

Obbina Abani, Ali Abbas, Fatima Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Nabeel Abdallah, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, Basir Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Abeer Ul Amna, Katrina Abernethy, Adebanke Aboaba, Hani Abo-Leyah, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Hyacinth-John Abu, Ahmad Abu-Arafeh, Syed M Abubacker, Akata Abung, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Sarah Acheampong, Janet Acheson, Andrés Acosta, Catherine Acton, Jacqueline Adabie-Ankrah, Fiona Adam, Matthew Adam, Huzaifa Adamali, Carol Adams, Charlotte Adams, Kate Adams, Richard Adams, Tim Adams, Kirsty Adcock, Jemaimah Addai, Ade Adebiyi, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Joyce Adeyemi, Rina Adhikary, Gabrielle Adkins, Adnan Adnan, John Aeron‐Thomas, Debbie Affleck, Carmel Afnan, Muhammad Abdur Rahman Afridi, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Penny Agent, Sunil Aggarwal, Arameh Aghababaie, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, M. Ridwan Said Ahmad, Syed A. Ahmad, Asim A. Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Iram Ahmed, Irshad Ahmed, Khaled Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sara Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Sana Ahmed, Sana Ahmer, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Olugbenro Aktinade, Ahmad Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Narendra Aladangady, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki S. Alatzoglou, Paul Albert, Lorraine Albon, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ana Alegria, Alison Alexander, John H. Alexander, Peter Alexander, Charlotte Alford, Julyan Al-Fori, Laith Alghazawi, Bahij Al-Hakim, Shams Al‐Hity, Ali Ali, Asad Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohammad Ali, Nayab Ali, Oudai Ali, Sakina Ali, Syed Ahsan Ali, Abid Alina, Fine Aliyuda, Katrin Alizaedeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Moutaz Alkhusheh, Fiona Allan, Alison Allanson, Robert Allcock, Eireann Allen, Kerry Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Kathryn Allison, Bethan Allman, Lynne Allsop, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Bashar Al‐Sheklly, Sara Altaf, Mary Alvarez, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Sarah-Jayne Ambler, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Ken Amenyah, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Amjad Amjad, Neelma Amjad, Victoria Amosun, Khaled Amsha, Pugh Amy, Atul Anand, Samantha Anandappa, Julie Anderson, Laura Anderson, Michelle A. Anderson, Nicola Anderson, Rachel Anderson, Rory Anderson, Wendy G. Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Marie Anne Ledingham, Jessica Annett, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Anu Varghese, Muhammad Naveed Anwar, Aristeidis Apostolopoulos, Diane Appleyard, Maia Aquino, Bianca Araba, Samuel Aransiola, Mariana E. G. de Araújo, Ann Archer, Denise Archer, Simon Archer, Christian Ardley, Ana-Maria Arias, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold, Dhawal Arora, Kavan Arora, Pardeep Arora, Rishi Arora, Arslam Arter, Ayush Arya, Rita Arya, Denisa Asandei, Adeeba Asghar, Catherine Ashbrook-Raby, Helen Ashby, Jan Ashcroft, John Ashcroft, Samuel Ashcroft, Deborah Asher, Ayesha Ashfaq, Abdul Ashish, Sally Ashman-Flavell, Ashok Raj, Abd-El-Aziz Ashour, Muhammad Ashraf, Saima Ashraf, Mohammad B Ashraq, Deborah Ashton, Susan Ashton, Andrew Ashworth, Rebecca Ashworth, Arshia Aslam, Harshini Asogan, Atif Asrar, Omar Assaf, Raine Astin-Chamberlain,

BackgroundIn this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.MethodsThis randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation ( ...

Elsevier BV

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Eugenia Abaleke, Mustafa Abbas, Sadia Abbasi, Alfie Abbott, Ashraf Omar Abdelaziz, Sherif Abdelbadiee, Mohamed S. Attia, Basir Abdul, Althaf Abdul Rasheed, Rezan A. Kadir, Abdulfatahi Abdulmumeen, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer UA Abeer Ul Amna, Adebanke Aboaba, Hani Abo-Leyah, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Hyacinth-John Abu, Ahmad Abu-Arafeh, Syed M Abubacker, Akata Abung, Yaa Aceampong, Devikumar Acharya, Janet Acheson, Andrés Acosta, Catherine Acton, Jacqueline Adabie-Ankrah, Fiona Adam, Matthew Adam, Huzaifa Adamali, Carol Adams, Kate Adams, Richard Adams, Tim Adams, Malgorzata Adamus, Kirsty Adcock, Aderonke Adebiyi, Ken Adegoke, Vicki Adell, Aldrin Adeni, Sherna Adenwalla, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Joyce Adeyemi, Elizabeth Adeyeye, Gabrielle Adkins, Adnan Adnan, John Aeron‐Thomas, Lynn Afari, Debbie Affleck, Carmel Afnan, Deborah Afolabi, Muhammad Abdur Rahman Afridi, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, Judith Agwada-Akeru, Kwame A Agyapong, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Jonathan Ah-Chuen, Mahin Ahmad, Ashar Ahmed, Bilal Ahmed, Forizuddin Ahmed, Iram Ahmed, Irshad Ahmed, Liban Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sara Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Sana Ahmer, Dhiraj Ail, Adam Ainsley, Mark Ainsworth, Myriam Aissa, Lucy Aitchson, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Muhammad Nadeem Akhtar, Nasim Akhtar, Suha Akili, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Umeh Akudo, Asma Al Balushi, Majd Al Dakhola, Narendra Aladangady, Sajid Alam, Abbas Al-Asadi, Kyriaki S. Alatzoglou, Lorraine Albon, Stephen Alcorn, Aggie Aldana, David Alderdice, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ana Alegria, Alison Alexander, John H. Alexander, Peter DG Alexander, Julyan Al-Fori, Bahij Al-Hakim, Shams Al‐Hity, Ali Ali, Anyat Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohammad Ali, Oudai Ali, Sakina Ali, Syed Ahsan Ali, Abid Alina, Katrin Alizaedeh, Maithem Al-Jibury, Moutaz Alkhusheh, Alison Allanson, Robert Allcock, Eireann Allen, Jonathan P. Allen, Kerry Allen, Louise Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Kathryn Allison, Bethan Allman, Lynne Allsop, Christine Almadenboyle, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Warkaq Al-Shamkhani, Bashar Al‐Sheklly, Mary Alvarez, Maysaa Alzetani, Susan Amamou, S Ambalavanan, Sarah-Jayne Ambler, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Amjad Amjad, Victoria Amosun, Khaled Amsha, Atul Anand, Samantha Anandappa, Julie Anderson, Laura Anderson, Michelle A. Anderson, Nicola Anderson, Rachel Anderson, Rory Anderson, Prematie Andreou, Angela Andrews, Jill Andrews, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Anu Varghese, Muhammad Naveed Anwar, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Bianca Araba, Angela Aramburo, Ann Archer, Denise Archer, Simon Archer, Christian Ardley, Ana-Maria Arias, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold, Dhawal Arora, Pardeep Arora, Rishi Arora, Arslam Arter, Ganesh Arunachalam, Rita Arya, Salma Asam, Denisa Asandei, Adeeba Asghar, Catherine Ashbrook-Raby, Helen Ashby, Jan Ashcroft, John Ashcroft, Ayesha Ashfaq, Abdul Ashish, Sally Ashman-Flavell, Ashok Raj, Muhammad Ashraf, Saima Ashraf, Mohammad B Ashraq, Deborah Ashton, Susan Ashton, Andrew Ashworth, Rebecca Ashworth, Harshini Asogan, Julia Asplin, Atif Asrar, Omar Assaf, Raine Astin-Chamberlain, Deborah Athorne, Christopher Atkins, Stacey Atkins, John Atkinson, Vicki Atkinson, Ahmed Attiq, Paula Aubrey, Suzannah August, Aye CT Aung, Hnin Aung, Kyaw Thu Aung, Nini Aung, Zaw Myo Aung, Emily Austin, Karen Austin, Miriam Avery, Joanne Avis, Cristina Avram, Paula Avram, Gabriel Awadzi, Aszad Aya, Eman Ayaz, Amanda Ayers, Vivek Ayra, Jawwad Azam, Mohammed Azharuddin, Ghazala Aziz, Ashaari Azman Shah, Giada Azzopardi, Hocine Azzoug, Nasaruilla Babajan, Fiyinfoluwa Babatunde, Melvin Babi, Babiker Babiker, Gayna Babington, Matthew Babirecki, Adetona O Babs-Osibodu, Gina Bacon, Jenny Bacon, Bibi Badal, Gurpreet R Badhan, Shreya Badhrinarayanan,

BackgroundAzithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.MethodsIn this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals ...

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Obbina Abani, Ali Abbas, Fatima Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Nabeel Abdallah, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, Basir Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Abdullah Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Ul Amna Abeer Ul Amna, Katrina Abernethy, Adebanke Aboaba, Hani Abo-Leyah, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Hyacinth-John Abu, Ahmad Abu-Arafeh, Syed M Abubacker, Akata Abung, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Sarah Acheampong, Janet Acheson, Andrés Acosta, Catherine Acton, Jacqueline Adabie-Ankrah, Fiona Adam, Matthew Adam, Huzaifa Adamali, Carol Adams, Charlotte Adams, Kate Adams, Richard Adams, Tim Adams, Kirsty Adcock, Ade Adebiyi, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Joyce Adeyemi, Binay Adhikari, Rina Adhikary, Gabrielle Adkins, Adnan Adnan, John Aeron‐Thomas, Debbie Affleck, Carmel Afnan, Muhammad Abdur Rahman Afridi, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Mohammad Ahmad, Syed A. Ahmad, Asim A. Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Iram Ahmed, Irshad Ahmed, Khaled Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sara Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Sana Ahmed, Sana Ahmer, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Olugbenro Aktinade, Ahmad Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Narendra Aladangady, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki S. Alatzoglou, Paul Albert, Lorraine Albon, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ana Alegria, Alison Alexander, John H. Alexander, Peter Alexander, Julyan Al-Fori, Laith Alghazawi, Bahij Al-Hakim, Shams Al‐Hity, Ali Ali, Asad Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohammad Ali, Nayab Ali, Oudai Ali, Sakina Ali, Syed Ahsan Ali, Abid Alina, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Moutaz Alkhusheh, Fiona Allan, Alison Allanson, Robert Allcock, Eireann Allen, Kerry Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Kathryn Allison, Bethan Allman, Lynne Allsop, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Bashar Al‐Sheklly, Sara Altaf, Mary Alvarez, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Sarah-Jayne Ambler, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Amjad Amjad, Neelma Amjad, Victoria Amosun, Khaled Amsha, Pugh Amy, Atul Anand, Samantha Anandappa, Julie Anderson, Laura Anderson, Michelle A. Anderson, Nicola Anderson, Rachel Anderson, Rory Anderson, Wendy G. Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Anu Varghese, Muhammad Naveed Anwar, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Maia Aquino, Bianca Araba, Samuel Aransiola, Mariana E. G. de Araújo, Ann Archer, Denise Archer, Simon Archer, Christian Ardley, Ana-Maria Arias, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold, Dhawal Arora, Kavan Arora, Pardeep Arora, Rishi Arora, Arslam Arter, Ayush Arya, Rita Arya, Denisa Asandei, Adeeba Asghar, Catherine Ashbrook-Raby, Helen Ashby, Jan Ashcroft, John Ashcroft, Samuel Ashcroft, Georgia Asher, Ayesha Ashfaq, Abdul Ashish, Sally Ashman-Flavell, Ashok Raj, Abd-El-Aziz Ashour, Muhammad Ashraf, Saima Ashraf, Mohammad B Ashraq, Deborah Ashton, Susan Ashton, Andrew Ashworth, Rebecca Ashworth, Arshia Aslam, Harshini Asogan, Atif Asrar, Omar Assaf, Raine Astin-Chamberlain, Deborah Athorne,

BackgroundAspirin has been proposed as a treatment for COVID-19 on the basis of its anti-thrombotic properties. We aimed to evaluate the efficacy and safety of aspirin in patients admitted to hospital with COVID-19.MethodsIn this randomised, controlled, open-label, platform trial, several possible treatments were compared with usual care in patients hospitalised with COVID-19. The trial took place at 177 hospitals in the UK, two hospitals in Indonesia, and two hospitals in Nepal. Eligible and consenting ...

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Sonia Labeau, Elsa Afonso, Julie Benbenishty, Bronagh Blackwood, Carole Boulanger, Stephen J. Brett, Silvia Calviño-Günther, Wendy Chaboyer, Fiona Coyer, Mieke Deschepper, Guy François, Patrick M. Honorè, Radmilo Janković, Ashish K. Khanna, Mireia Llauradó‐Serra, Frances Lin, Louise Rose, Francesca Rubulotta, Leif Saager, Ged Williams, Stijn Blot, Dritan Muzha, Antoni Margarit Ribas, Fernando Lipovesty, Cecilia Loudet, Fiona Coyer, Philipp Eller, Nafseen Mostafa, Patrick M. Honorè, Vanesa Mercado Telleria, Jasmina Smajić, Paula Cristina Nogueira, Khalid Mahmood Khan Nafees, Romuald Hentchoya, Louise Rose, Javiera Soledad, Frances Lin, Yenny Cardenas, A. Reyes, Alan S̆ustić, Meropi Mpouzika, Tamas Vymazal, Hanne Irene Jensen, Hernán Aguirre-Bermeo, Liivi Maddison, M. Valta, Silvia Calviño-Günther, Frank Bloos, Faustina Excel Adipa, Vasilios Koulouras, Judy Enamorado Enamorado, Zsuzsann Ágoston, Hrönn Birgisdóttir, Amit Gupta, Mohan Gurjar, Bram Kilapong, Seyed Mohammad Reza Hashemian, Ignacio Martín‐Loeches, Julie Benbenishty, Andrea Cortegiani, Kelly Fletcher, Yoshiro Hayashi, Wangari Waweru-Siika, Khalid Abidi, Sang‐Min Lee, B. Hadri, Mihails Dolgusevs, Fayez Abillama, Tomas Jovaiša, Cyril A Thix, Muhammed Elhadi, Mohd Basri Mat Nor, Shanti Ratnam, Mohd Zulfakar Mazlan, Sundaresan Maiyalagan, Luis Alejandro Sánchez‐Hurtado, Adrian Belii, Mendsaikhan Naranpurev, Prabha Gautam, Dylan W. de Lange, Rachael Parke, Rose Ilesanmi, Mirjana Shosholcheva, Antonija Petosic, Ranveig Lind, Madiha Hashmi Ffarcsi, Javier Bogarin, Aaron Mark Hernandez, Małgorzata Mikaszewska-Sokolewicz, B. A. M. Sousa, Dana Tomescu, Dorel Săndesc, Théogène Twagirumugabe, V. G. Gusarov, Maie Salem Ebaid, Radmilo Janković, Gari Slobodianiuk, Andrea Martonova, Rihard Knafelj, Mervyn Mer, Emilio Maseda, Bernardo Panka, Joerg C. Schefold, Eva Joelsson‐Alm, Konlawij Trongtrakul, Lorna Merritt-Charles, Lamia Ouanes-Besbes, Yalım Dikmen, Л. В. Згржебловська, Mark Fielding, Francesca Rubulotta, Ashish K. Khanna, Leif Saager, Ingrid von der Osten, Dritan Muzha, Alban Greca, Alma Cani, Nordian Xhindi, Genci Hyska, Antonio Margarit Ribas, Susana Pinto-Castilla, Paulo Alves, Romina Esposito, Emanuel Valgolio, John Thomas Sanchez Miñope, Antonio Abdala, Maria Ayala, Silvina Bravo, Ana Bantar, Patricia Delgado, Gustavo Badariotti, Fernando Lipovestky, Ana María Díaz, Pablo Saul, Mariano Setten, Alejandra Aucapina, Ysica Acosta, V. González, Luis Alberto Camputaro, Fernando Baccaro, Robert Villa, Ana María Díaz, Marcela Mastantuono, Emiliano Dean, Oscar Fernández Rostello, Patricia Brizuela, Julio Ricardo Bartoli, Matias Guereschi, Cristian Quiroga, Sofia Putruele, Paula Romina Villegas, Veronica Curilen, Rubén Fernández, Mariangeles Gabriela Nocheretti, Rosana Gabriela Escalante, Cecilia Loudet, Silvia Fernandez, Ana Laura González, Gustavo Andres Alvarez, Federico Iglesias, S. Jansen Chaparro, Graciela Zakalik, Gonzalo Pagella, Matías Baini, Pierina Arias Campos, Ignacio Sabbag, Armando Schmukler, Imelda Perdomo Fonseca, Gonzalo Martín Alvarez, Mário Ramirez, Fernando Velasco-Tapia, Carlos Alejandro Bascary, G. Giménez, Fernando Bertoletti, Esteban Milioto, Pablo Julio Maldonaldo Bonsignore, María Alejandra Fernández, Julie Smith, Tim Chimunda, Lorraine Thompson, Teena Maguire, Frances Lin, Wendy Chaboyer, Fiona Coyer, Stacey Watts, Marion Mitchell, Madeleine Powell, India Lye, Leanne Parsons, Nerilee Baker, Claire Reynolds, Amy Thompson, Kristy Masters, Kellie Sosnowski, Lynette Morrison, Gavin Leslie, Ramanathan Lakshmanan, Alexis Tabah, Wendy Brown, Sharon McDowell-Skaines, Andrea McLucas, Chris Smith, Mandy Tallot, Sarah Jones, Michelle Barakat‐Johnson, Thomas K. Leong, Rand Butcher, Kerrie Martin, Philipp Douschan, Dirk von Lewinski, Philipp Eller, René Schmutz, Uta Kolussi, Fatema Salman, Zainab Mahdi Ateya, Nafseen Mostafa, Koen De Decker, Niels Van Regenmortel, Anita Jans, Patricia Wijnands, Stefano Coremans, Patrick M. Honorè, David De Bels, Tanja Depuydt, Caroline Paillet, Luc‐Marie Jacquet, Walter Swinnen, Francis Hannes, M Mergeay, Stijn Van de Velde, Silvie Allaert, Pieter Hoste, Christophe Borin, Sandrine Balon, Vincent Fraipont, Patrick Biston, Nicolas De Schryver, Thierry Dugernier, Ilse Van Cotthem, Vanesa Mercado Telleria, Jasmina Smajić, Angélica Olivetto de Almeida, Sílvia Angélica Jorge, Delmiro Becker, Raysa Cristina Schmidt, Evellyn Oliveira, Aline de Oliveira Ramalho, Eliane Mazócoli, Audrey Fioretti, Elaine Barros, Letícia Faria Serpa, Suzana Maria Bianchini, Ticiane Carolina Gonçalves Faustino Campanili, Taís Pantaleao, Paulo Carlos Garcia, Ana Lucia Vitti Ronchini, Rayanne Santos, Khalid Mahmood Khan Nafees, Nurulhuda Binti A. Manap, Romuald Hentchoya, Sean M. Bagshaw, Dominic Carney, Sean M. Bagshaw, Jon Davidow, Sean M. Bagshaw, Ella Rokosh, Sean M. Bagshaw, Andréa Maria Laizner, Samantha Smith, Megan McQuirter, Betty Star Kampayana, René Favre, Martin Sills, Andréa Maria Laizner, Julie Dallaire, Andréa Maria Laizner, Cathy Becker, Sherissa Microys, B. Bowes, Jennifer LaJeunesse, Rishi Ghosh, Jacqueline Baptiste-Savoie, Rose Raizman, Sean M. Bagshaw, Gabriel Suen, Noushin Taghavi, Orla Smith, Clare Fielding, Louise Rose, J R López Canales, Pia Molina, Javiera Chaparro, Maria Idalia Sepulveda, Matias Jesús Flamm Zamorano, P..c. Túlio Monteiro de Castro e Abreu Rocha, Ximena Villanueva,

Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were ...

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Saul N. Faust, Richard Haynes, Christine E. Jones, Natalie Staplin, Elizabeth Whittaker, Thomas Jaki, Ed Juszczak, Enti Spata, Mandy Wan, Alasdair Bamford, Paul Dimitri, Adam Finn, John Furness, Athimalaipet V Ramanan, Chris Gale, Katrina Cathie, Simon B. Drysdale, Jolanta Bernatoniene, Clare Murray, Charles Christoph Roehr, Paul Fleming, Andrew Riordan, Srini Bandi, Deepthi Jyothish, Jennifer Evans, Marieke Emonts, Dominic F. Kelly, Nazima Pathan, Patrick Davies, Rosie Hague, Louisa Pollock, Malcolm G. Semple, Leon Peto, J. Kenneth Baillie, Maya H Buch, Katie Jeffery, Marian Knight, Wei Shen Lim, Alan Montgomery, Aparna Mukherjee, Andrew Mumford, Kathy Rowan, Guy Thwaites, Marion Mafham, Jonathan Emberson, Martin Landray, Peter Horby, Lucy C. Chappell, Jeremy Day, DV Dung, Jeremy Day, NN Quang, Prof Binh, Erlina Burhan, Bachti Alisjahbana, Janak Koirala, S Basnet, Evelyne Kestelyn, Buddha Basnyat, Pradip Gyanwali, RL Hamers, Peter Sandercock, Janet Darbyshire, David L. DeMets, Robert Fowler, David G. Lalloo, Mohammed Munavvar, Ian Roberts, Adilia Warris, Janet Wittes, A Craddock-Bamford, Janet Barton, Ahmet Başoğlu, Rosemary Brown, Wojciech Brudlo, Emmanuelle Denis, Lucy Fletcher, Sarah Howard, Sabrina Musini, K. Taylor, Guanglin Cui, Bob Goodenough, Andy J. King, M Lay, David R. Murray, W. Grant Stevens, Karl Wallendszus, Robert C. Welsh, Charles Crichton, Jane C. Davies, Raph Goldacre, Charlie Harper, F Knight, Miles A. Nunn, Hizni Salih, John J. Welch, Mark Campbell, Guilherme Pessoa-Amorim, Mohamed A. Zayed, Jonathan D. Wiles, GRANT P. BAGLEY, Scott J. Cameron, Sarah Chamberlain, Barbara Farrell, Hannah Freeman, Ann R. Kennedy, Anne Whitehouse, Sara Wilkinson, Caroline Wood, Christina Reith, K Davies, Heather Halls, Lisa Holland, Robert Truell, Kevin C. Wilson, Emma Lingwood, L. Howie, Michael P. Lunn, Penelope Rodgers, John Amuasi, Kathleen Baird, Ting Bao, Buddha Basnyat, Mustapha Bittaye, Joseph Bonney, Umberto D’Alessandro, Meghnath Dhimal, Pradip Gyanwali, RL Hamers, T Huyen, Abubacarr Jagne, Abhilasha Karkey, Evelyne Kestelyn, Oumou Maïga, E Matey, Behzad Nadjm, Jeremy Nel, Suman Pant, Khairunnisa Puspatriani, Mutia Rahardjani, S Raijal, Helen Rees, Atika Rimainar, Charles W.M. Roberts, Anna Rocca, Sailendra Kumar Duwal Shrestha, Effua Usuf, C. Vidaillic, Fitria Wulandari, Amit Alexander, M. R. Amezaga, Charlotte Armah, Asma Asghar, Paula Aubrey, Kerry Barker-Williams, Amanda Barnard, John R. Bartholomew, Dawn Beaumont-Jewell, Simon Beddows, J. Beety, Chris Birch, Peter Boyle, Morwenna Brend, Matthew Brookes, Claire Callens, Danielle Campbell, Helen Campbell, Hugo Ten Cate, Emma S. Chambers, K Chapman, Antoinette B. Coe, Joanne Collins, Sarah Crawshaw, Sandeep R. Das, Anthony De Soyza, Erika Denton, Pamela Dicks, Mary Dolman, Kate Donaldson, Lucy Dowden, Shawn Dowling, Charles G. Drake, Hayley Duckles-Leech, Helen Duffy, Lee Gerdes, Kristen Gibbons, Lorena Almeida Gill, Kimberly Gilmour, Joanne Goodwin, James E. Graham, Christopher Green, Claire Hall, Alistair S. Hall, Kate Hampshire, Jane Hanson, T Harman, Helen Harper, Susan T.L. Harrison, James W. Hicks, Helen Hodgson, Michael Hough, Susan Jackson, Graham Johnson, Jodie Kirk, Nicholas R. Lemoine, Chris Levett, S Lock, Teresa Lockett, M Logan, Kaatje Lomme, Jing‐chao Luo, Nigel A.J. McMillan, Helen Membrey, Nhlanhla Mguni, Jane Minton, H Monaghan, Shawn N. Murphy, Natasha Muzengi, Madiha Naz, Ian Nickson, Miranda Odam, Udeme Ohia, Eleanor OKell, Antonio Oliver, Karen Pearson, Kirsty Pine, Richard J. Pleass, David A. Porter, Linda Porter, Alison Potter, Vanessa Poustie, Steven Pratt, Anna Price, Alicia Priest, Anthony Rodgers, C. Rook, Pablo Ryan, S Sam, Phoebe Sharratt, James K. Sheffield, Justine Shenton, Karen Shirley, Timothy Skinner, Herbert B. Slade, Mihaela Sutu, Judy Taylor, E Thomas, Heather Tinkler, Alison Unsworth, R. Usher, William van’t Hoff, S E Walker, James Walters, E. Walton, Jenny Warmington, Emma Wayman, Patricia Williams, John Williamson, Deborah A. Williamson, Fiona Yelnoorkar, Marian Knight, Kenneth Hodson, Sue Pavord, Catherine Williamson, Louise Bowman, Fei Chen, Robert W. Clarke, Michelle Goonasekara, William G. Herrington, P. G. Judge, S Ng, David Preiss, Christina Reith, Emily Sammons, Dandan Zhu, C Arkley, Paul Bowker, Johanna Bruce, Victoria Byrne-Watts, G Chapman, Grahame J. Coleman, Tom Denwood, J.D. Gray, David A Harrison, Nancy Mather, Heather Pinches, A.R. Rees, Stephanie Rees, Gail Turner, Obbina Abani, Amr E. Abbas, Fatima Abbas, Jonathan R. Abbas, Kaja Abbas, Mustafa Abbas, Sadia Abbasi,

BackgroundPaediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C) emerged in April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess the effect of intravenous immunoglobulin or corticosteroids compared with usual care on duration of hospital stay for children with PIMS-TS and to compare tocilizumab (anti-IL-6 receptor monoclonal antibody) or anakinra (anti-IL-1 receptor ...

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Yaseen M. Arabi, Anthony Gordon, Lennie Derde, Alistair Nichol, Srinivas Murthy, Farah Al Beidh, Djillali Annane, Lolowa Al Swaidan, Abi Beane, Richard Beasley, Lindsay R. Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte Bradbury, Frank M. Brunkhorst, Meredith Buxton, Adrian Buzgau, Allen C. Cheng, Menno D. de Jong, Michelle A. Detry, Eamon Duffy, Lise J Estcourt, Mark Fitzgerald, Rob Fowler, Timothy D. Girard, Ewan C. Goligher, Herman Goossens, Rashan Haniffa, Alisa M. Higgins, Thomas Hills, Christopher M. Horvat, David T. Huang, Andrew J. King, François Lamontagne, Patrick R. Lawler, Roger Lewis, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Salim Malakouti, Daniel F. McAuley, Anna McGlothlin, Shay McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Susan C. Morpeth, Paul Mouncey, Katrina Orr, Rachael Parke, Rachael Parke, Asad E. Patanwala, Kathy Rowan, Marlene Santos, Christina Saunders, Christopher W. Seymour, Manu Shankar‐Hari, Steven Y. C. Tong, Alexis F. Turgeon, Anne Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Scott Berry, John C. Marshall, Colin McArthur, Derek Angus, Steven A. Webb, Farah Al-Beidh, Derek Angus, Djillali Annane, Yaseen M. Arabi, Abi Beane, Wilma van Bentum-Puijk, Scott Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte Bradbury, Frank Brunkhorst, Meredith Buxton, Allen C. Cheng, Lennie Derde, Lise J Estcourt, Herman Goossens, Anthony Gordon, Cameron Green, Rashan Haniffa, François Lamontagne, Patrick R. Lawler, Edward Litton, John C. Marshall, Colin McArthur, Daniel F. McAuley, Shay McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Paul Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Rachael Parke, Kathy Rowan, Marlene Santos, Christopher W. Seymour, Alexis F. Turgeon, Anne Turner, Frank L. van de Veerdonk, Steve Webb, Ryan Zarychanski, Yaseen M. Arabi, Lewis Campbell, Allen C. Cheng, Lennie Derde, Andrew Forbes, David Gattas, Cameron Green, Stéphane Héritier, Peter Krüger, Edward Litton, Colin McArthur, Shay McGuinness, Alistair Nichol, Rachael Parke, Rachael Parke, Sandra Peake, Jeffrey Presneill, Ian Seppelt, Tony Trapani, Anne Turner, Steve Webb, Paul J. Young, Zahra Bhimani, Brian H. Cuthbertson, Rob Fowler, François Lamontagne, John C. Marshall, Venika Manoharan, Srinivas Murthy, Marlene Santos, Alexis F. Turgeon, Ryan Zarychanski, Diptesh Aryal, Abi Beane, Arjen Dondrop, Cameron Green, Rashan Haniffa, Madiha Hashmi, Issrah Jawad, Deva Jayakumar, John C. Marshall, Colin McArthur, Srinivas Murthy, Timo Tolppa, Vanessa Singh, Steve Webb, Farah Al-Beidh, Derek Angus, Djillali Annane, Wilma van Bentum-Puijk, Scott Berry, Marc J. M. Bonten, Frank Brunkhorst, Maurizio Cecconi, Lennie Derde, Stéphan Ehrmann, Herman Goossens, Anthony Gordon, Colin McArthur, Paul Mouncey, Alistair Nichol, Lorraine Parker, Mathias W. Pletz, Pedro Póvoa, Gernot Rohde, Kathy Rowan, Steve Webb, Brian Alexander, Derek Angus, Kim Basile, Meredith Buxton, Timothy D. Girard, Christopher M. Horvat, David T. Huang, Kelsey Linstrum, Florian Mayr, Bryan J. McVerry, Stephanie K. Montgomery, Christopher W. Seymour, Richard Beasley, Marc J. M. Bonten, Allen C. Cheng, Nick Daneman, Lennie Derde, Robert Fowler, David Gattas, Anthony Gordon, Cameron Green, Peter Krüger, Colin McArthur, Steve McGloughlin, Susan C. Morpeth, Srinivas Murthy, Alistair Nichol, Mathias W. Pletz, David L. Paterson, Gernot Rohde, Steve Webb, Derek Angus, Wilma van Bentum-Puijk, Lennie Derde, Anthony Gordon, Peter Krüger, Edward Litton, John C. Marshall, Colin McArthur, Srinivas Murthy, Alistair Nichol, Balasubramanian Venkatesh, Steve Webb, Derek Angus, Scott Berry, Marc J. M. Bonten, Allen C. Cheng, Lennie Derde, Herman Goossens, Menno D. de Jong, John C. Marshall, Colin McArthur, Srinivas Murthy, Tim Uyeki, Steve Webb, Derek Angus, Yaseen M. Arabi, J. Kenneth Baillie, Richard Beasley, Scott Berry, Marc J. M. Bonten, Allen C. Cheng, Menno D. de Jong, Lennie Derde, Eamon Duffy, Rob Fowler, Herman Goossens, Anthony Gordon, Cameron Green, Thomas Hills, Colin McArthur, Susan C. Morpeth, Srinivas Murthy, Alistair Nichol, Katrina Orr, Rachael Parke, Rachael Parke, Asad E. Patanwala, Kathy Rowan, Steven Y. C. Tong, Tim Uyeki, Frank L. van de Veerdonk, Steve Webb, Derek Angus, Yaseen M. Arabi, J. Kenneth Baillie, Richard Beasley, Scott Berry, Marc J. M. Bonten, Frank Brunkhorst, Allen C. Cheng, Nichola Cooper, Olaf L. Cremer, Menno D. de Jong, Lennie Derde, Eamon Duffy, James Galea, Herman Goossens, Anthony Gordon, Cameron Green, Thomas Hills, Andrew J. King, Helen L. Leavis, John C. Marshall, Florian Mayr, Colin McArthur, Bryan J. McVerry, Susan C. Morpeth, Srinivas Murthy, Mihai G. Netea, Alistair Nichol, Kayode Ogungbenro, Katrina Orr, Rachael Parke, Asad Patawala, Ville Pettilä, Emma Rademaker, Kathy Rowan, Manoj Saxena, Christopher W. Seymour, Steven Tong Wendy Sligl,

To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19). Critically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloroquine, combination therapy of lopinavir-ritonavir and hydroxychloroquine or no antiviral therapy (control). The primary endpoint was an ordinal scale of organ support-free days. Analyses used a Bayesian cumulative logistic model and expressed treatment effects as an adjusted ...

Springer Science+Business Media

Artigo

Hesham Abdelhady, Marwa Abdelrazik, Zakee Abdi, D. Abdo, Amina Abdulle, Lynn Abel, Shrefee Abouzeenni, Gail Abrahamson, Yousuf Abusamra, Lisa C. Adams, Olumide Adebambo, Debo Ademokun, Neill K. J. Adhikari, Dominic Affron, Anu Aggarwal, Ronan Agno, Humayun Ahmad, Norfaizan Ahmad, Sophia Ahmed, Kate Ainscough, James Ainsworth, Giulia Airoldi, Lindianne Aitken, Francis Ajeneye, Naim Akhtar, Olajide Akinwumiju, Manaf Al-Bayati, Martin Albert, Meera Alderman, Ana Alegria, Brian Alexander, Peter Alexander, Jordan Alfonso, Hoodo Ali, Sabira Ali, Allameddine Allameddine, Sheila Allan, Isabelle Allard, Barbara Allen, B. Allen, Jess Allen, Laura K. Allen, Louise Allen, Suzanne Allibone, Richard Ambrosino, Kenneth Amenyah, Mariam Ammoun, Rekha Anand, Sai Priya Anand, Kristen Andersen, Corinne Anderson, Kevin L. Anderson, Thomas Anderson, Mark Andreae, Susan Andrews, Gregory Andrikopoulos, Aisha Anjum, Matthew Anstey, Micheline Antar, David Antcliffe, Alpha Anthony, Pierre Antoine, Vikram Anumakonda, George Apostolides, Latha Aravindan, Gill Arbane, Emily Arbon, Simon Archer, Noah Aref, Ana-Marie Arias, Chantal Armali, Joel Armer-Ducker, Michelle Armstrong, Sylvia Armstrong‐Fisher, John Arnold, Sarah Arnott, Andrea Arroyo, Valérie Arsenault, Diptesh Aryal, Adeeba Asghar, Glen Ashby, Deborah Asher, Ben Ashford, Suhail Ashgar, Murtaza Asif Ali, Angelique Aspinwall, Abigail Asquith, T Atallah, Richard Athay-Hunt, Udara Attanayaka, Rita Atugonza, M Aubé, Marie‐Christine Auclair, Karen Austin, Pauline Austin, Sidra Awan, Gina Bacon, Harleen Badhesha, Kavitha Bagavathy, Dawn Baglole, Clariza Bagnas, Catherine Bagot, Sean M. Bagshaw, Nadia Baig, Stephen J. Bailey, J. Kenneth Baillie, William Bain, Sanchia Baines, Aimi Baird, Charles Baker, Evelyn Baker, Penny Bakhtiari, Dhanalakshmi Bakthavatsalam, Morteza Balaie, Gagan Bali, Sonya Balkee, Amy Ballinger, Amy Bamford, Peter Bamford, Millie Banerjee, Lauren B. Banks, Jonathan Bannard‐Smith, Nancy Banning, Bharat Bansal, Robert Banthorpe, Ian J. Barbash, Alex Barber, Russell Barber, Miriam Barbosa, Mercedes Barillas, Ryan Bariola, Gareth J. Barker, Nicky Barnes, Matthew Barnett, N. Barnett, Rebecca M. Baron, Robert D. Bart, Jazz Bartholomew, Shauna Bartley, Dávid Barton, Jan Barwell, Archana Bashyal, Kim Basile, Frances Bass, Christopher Bassford, Pavinder Bassi, Betsy Bassis, Ian J. Bateman, Michelle Bates, Samantha Bates, Donna Batty, Kris Bauchmüller, Peter Baughan, Lydia Baxter, Charlotte Baylem, Lee Bayliss, Madeleine Bayne, Eileen Bays, Renée Bazin, Gregory Beard, Kirk Beard, Richard Beasley, Lynette Beaudin, Julie Beaudoin, Guillaume Beaudoin-Bussières, Seonaid Beddows, Caroline Bedford, Deborah Beer, Salma Begum, Jasmine Beharry, Xiao Bei Zhao, Nathalie Belec, Gillian Bell, Glenda Bell, Joshua Bell, David Bellemare, Fatna Benettaib, Ann Beninato, Mehdi Benlarbi, Alexander Bennett, Christopher Bennett, Carrie Bennett-Mills, Andrea Benoit, J G Benstead, Dionne Bentley, Lauren Berg, Colin Bergin, Claudia Berscheid, Janis Best-Lane, Emily Bevan, Jeremy Bewley, Ashley Beyerl, Sanjay Bhagani, Khushpreet Bhandal, Simon C. Biddie, Jennifer Biemans, Kelly Bignell, Shailesh Bihari, Maude Bilodeau, Carron Bilton, Martin Binney, Alexandra Binnie, Julian Bion, Catherine Birch, Janine Birch, K Birchall, Isobel Birkinshaw, Raquel Bisa, Ethel Black, Bethany Blackledge, Stuart Blackmore, Annette Blackwell, Loraine Blackwood, Yvonne Bland, Mary Blanton, J W Blaxland, Donna Blofield, Margie Blom, Jasmin Board, Aneta Bociek, Sherin Bodh, Virginie Boisclair, Sam Bolton, Wayne Bolton, Hayley Bond, Stephen Bonner, Wendy Bonnert, Leigh Boorman, Catherine Booth, Bárbara Borgatta, Cameron Borhani, Naomi Borkent, Rachel Borrell, Zöe Borrill, Mamu Boshir, Brandon Bouchard, Marie-Claude Boulanger, Dounia Boumahni, Catherine Bourassa, Michelle Bourne, Richard S Bourne, D. Le-Thi Huong Boutin, Marianne Boutin, Darren Bowen, James D. Bowen, Helen Bowler, Geoff Bowyer, Carmel Boyd, Craig Boyd, Maxine Boyd, Lucie Boyer, Rebecca Boyles, Gordana Bozovic, David Brack, Charlotte Brackstone, Rob Bradburn, Barry Bradley, Paul Bradley, Sarah Bradshaw, Jane Brailsford, Susan R. Brailsford, Emily Brant, Angela Brazier, Pamela Bremmer, Morwenna Brend, Val Brennan, Stephen J. Brett, Chris Brewer, Kathy Brickell, M. Briggs, Christopher E. Brightling, Nicole Brillinger, Lutece Brimfield, Stéphanie Brisson, Terri Brittin, Laurent Brochard, Andrew Broderick, David Broggio, Farooq Brohi, Ceri Brookes, Nicole Brooks, Randy Broom, Marie Browett, Chloë Brown, Elizabeth R. Brown, Louise Brown, Mark J. Brown, Rachel Brown, Wayne Brown, Marie-Eve Brulotte, Emilie Brunet, Nigel J. Brunskill, Kayla Bryan-Morris, Julie Buchan, Alexis Buchanan, Kathleen Buckmire,

Importance The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive. Objective To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19. Design, Setting, and Participants The ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or confirmed COVID-19 between March 9, 2020, and January 18, 2021, within ...

American Medical Association

Artigo

Ary Serpa Neto, Carmen Sílvia Valente Barbas, Fabienne D. Simonis, Antonio Artigas, Jaume Canet, Rogier M. Determann, James Anstey, Göran Hedenstierna, Sabrine N.T. Hemmes, Greet Hermans, M. Hiesmayr, Markus W. Hollmann, Samir Jaber, Ignacio Martín‐Loeches, Gary Mills, Rupert M. Pearse, Christian Putensen, Werner Schmid, Paolo Severgnini, Roger Smith, Tanja A. Treschan, Edda Tschernko, Marcos F. Vidal Melo, Hermann Wrigge, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J. Schultz, Adam Bell Bell, Agreta Gecaj-Gashi, Ahmet Dilek, Ahmet Sukru Denker, Akut Aytulun, Peter Kienbaum, Alastair Rose, Alessandro Bacuzzi, Alexandre Biasi Cavalcanti, Alexandre Chan, Alexandre Molin, Alison Ghosh, Alistair Roy, Amanda Cowton, Amanda Skinner, Amanda Whileman, Amy McInerney, Ana Carolina Peçanha, Andrea Cortegiani, Andrej Šribar, Andrew Bentley, Andrew Corner, Angela Pinder, Anil Hormis, A. Walker, Antonio Artigas, Ary Serpa Neto, Barry Dixon, Ben Creagh‐Brown, Carlo Alberto Volta, Carlos Airton Severo Munhoz, Carly Brown, Carmen Sílvia Valente Barbas, Carmen Scott, Caroline Wreybrown, Catherine Plowright, Charlotte Downes, Cheryl Padilla-Harris, Chloe Hughes, Christian Frey, Christian Putensen, Christian Schlegel, Christine Boyd, Christine Ryan, Christoph Muench, Christopher Smalley, Çiler Zincircioğlu, Clair Harris, Claire Kaloo, Claire Matthews, Claire Miller, Claire Pegg, Clare Bullock, Clare Mellis, Cláudio Piras, Colette Seasman, Cristina Santos, Daniel Beraldo, Daniel Collins, Daniel Hadfield, Daniel Hull, Daniel Prado, David Pogson, Angela J. Rogers, David M. Shaw, Davide D’Antini, Dawn Trodd Denise Griffin, Debbie Weller, Deborah S. Smith, Deborah Wilson, Demet Aydın, Denise Donaldson, Donatella Mestria, Edda Tschernko, Eduardo Di Lauro, Eliane Bernadete Caser, Elisa Seghelini, Emanuel Cirstea, Eoin Young, Erna Alberts, Evren Şentürk, Fabienne D. Simonis, Farooq Brohi, Fatma Ülger, Feda Kahveci, Fernando José da Silva Ramos, Frank van Haren, Güldem Turan, Gabriele Sales, Gary Mills, Gary Mills, Gayle Clifford, Gilda Cinnella, Giovana Colozza Mecatti, Giuseppe Melchionda, Göran Hedenstierna, Greet Hermans, Greet Hermans, Gülay Eren, Hannah Crowther, Hazel Spencer, Heather Blaylock, Helen Green, Helen Robertson, Helen Rodgers, H. Keipp Talbot, Helen Wong, Helena Barcraft-Barnes, Helga Ceunen, Henrik Reschreiter, Hermann Wrigge, Hermann Wrigge, Hülya Ulusoy, Hüseyin Toman, Iain J McCullagh, Ian White, Ignacio Martín‐Loeches, Ingeborg Welters, Ingrid van den Hul, Isabela Ambrósio Gava, Isabelle Reed, Işıl Köse, Israel Silva Maia, James Limb, Jan Máca, Jane Adderly, Jane Hunt, Jane Martin, Jane Montgomery, Jane Snell, Jaume Canet, Jean Charles Monteiro Salgado, Jenny Ritzema, Jeremy Bewley, Jo-Anne Howe, Johan Decruyenaere, Johanna Mouland, Johanna Stickley, Johannes Mellinghoff, J. Criswell, John Knighton, Jonathan Cooper, Jonathan S. Harrison, Jonathan Paddle, José Augusto Santos Pellegrini, Joseph S. Needleman, Julian Giles, Julie Camsooksai, Julie Furneval, Julie Toms, Karen Burt, Karen Simeson, Karen Williams, Karl Blenk, Kate Turner, Katie Lynch, Katie Sweet, Keith Hugill, Kelly Matthews, Kessia Ruas, Kevin Clarkson, Jacobus Preller, Kristen Joyce, Laura Ortiz-Ruiz, Laura Youds, Lee Tbaily, Lisa Barrell, Lisa Grimmer, Lokman Soyoral, Lorenzo Peluso, Lorna Murray, L. Bergstrom Niska, Louise Tonks, Lousie Fasting Fasting, Luc DeCrop, Luca Brazzi, Lucia Mirabella, Lucy Cooper, Luis Fernando Falcão, Lynn Everett, Malcolm Watters, Mandy Carnahan, Marc Bourgeois, Marcelo Gama de Abreu, Marcelo Luz Pereira Romano, Marco Botteri, Marcos F. Vidal Melo, Marcos F. Vidal Melo, Marcus J. Schultz, Marcus J. Schultz, Maria Faulkner, Marijana Krkusek, Marina Bahl, Mark Holliday, Mark Kol, Mark Pulletz, Markus W. Hollmann, Marta Kozlowski, Matea Bogdanović Dvorščak, Matija Jurjević, Marion Koopmans, Mauricio Morales, Maximilian S. Schaefer, Melinda Brazier, Meredith Harris, Michael Devile, M. Hiesmayr, Michaël Kuiper, Michael Parris, Michael Sharman, Milan Kratochvíl, Mohamed Ramali, Moreno Calcagnotto dos Santos, Natalie Bynorth, Natalie Wilson, Nathalie Anquez, Nathan T. M. Huneke, Nazım Doğan, Nenad Karanović, Nicholas T. Tarmey, Nicolás Carreño, Nicola Fisher, Nicola Lamb, Nicola Venner, Nigel Hollister, Nur Akgün, Osman Ekinci, Owen Boyd, Paolo Pelosi, Paolo Pelosi, Paolo Severgnini, Paolo Severgnini, Pardeep Gill, Pasquale Raimondo, Pasquale Verrastro, Paul Pulak, Pauline Fitzell, Paul Dark, Pedro Alzugaray, Perihan Ergin Özcan, Peter Macnaughton, Petr Štourač, Philip Hopkins, Pieter R. Tuinman, Rachel Pearson, Rachel Walker, Rafaella Souza dos Santos, R Caione, Ramprasad Matsa, Rebecca Oliver, Reni Jacob, Richard Howard-Griffin, Rob B. P. de Wilde, Robert Plant, Robin Hollands, Rodrigo Biondi, Roger Smith, Roger Smith, Rogier M. Determann, Rola Jaafar, Rossana Avendaño, Rupert M. Pearse, Ruth Salt, Ryan Humphries, Sérgio Felix Pinto, Sabrine N.T. Hemmes, Sallyane Pearson, Sam Hendry, Samir Jaber,

Scant information exists about the epidemiological characteristics and outcome of patients in the intensive care unit (ICU) at risk of acute respiratory distress syndrome (ARDS) and how ventilation is managed in these individuals. We aimed to establish the epidemiological characteristics of patients at risk of ARDS, describe ventilation management in this population, and assess outcomes compared with people at no risk of ARDS.PRoVENT (PRactice of VENTilation in critically ill patients without ARDS ...

Elsevier BV

Artigo

Carol J. Peden, Tim Stephens, Graham Martin, Brennan C Kahan, Ann Thomson, Kate Rivett, Duncan Wells, Gerry Richardson, Sally Kerry, Julian Bion, Rupert M. Pearse, Rupert M. Pearse, Carol J. Peden, Tim Stephens, Julian Bion, Graham Martin, Ann Thomson, Brennan C Kahan, Sally Kerry, Kate Rivett, Duncan Wells, Gerry Richardson, Stephen J. Brett, Gareth L. Ackland, Michael P. W. Grocott, Peter Holt, Glenn Robert, Obioha C. Ukoumunne, J. B. H. Waring, Kirsty Everingham, Mandeep Phull, David Cromwell, Rachel Evley, Richard Lilford, David Kocman, Miqdad Asaria, J. B. H. Waring, Carolyn Tarrant, Fan Yang, Ajit Abraham, Pieter Bothma, Daniel Conway, C Stapleton, Mark Edwards, Gary Minto, David Saunders, Tom Owen, Carl Waldmann, Paul Hayden, Michael Gillies, Sean Tighe, Neil Smith, Monty Mythen, David J. Murray, Dileep N. Lobo, M. Leuwer, Justin Kirk-Bayley, Simon Howell, Anthony Gordon, I D Anderson, Jose Lourtie, Simon Walker, Sharon Drake, Dave Murray, Nick Watson, Tamás Szakmány, Robert P. Sutcliffe, Graham Martin, Ravi Mahajan, Alan Girling, Gordon Forbes, Omar Faiz, Mark Blunt, Surjait Singh, Alistair Steel, Kate Wong, Leilani Cabreros, Pieter Bothma, Vivek Chitre, A. Obideyi, Dhiraj Ali, Karl Blenk, Dan Broad, Andreas Brodbeck, Rajesh Dumpala, A. Engel, Ranjit Ganepola, Sudha Garg, Mike Gay, Michael Karlikowsk, Edward Lams, Dean Millican, Inga Misane, Ajaya Mull, Veena Naik, Nathan Pushpa, Chris Nutt, Saravanna Sagadai, Hazel Stuart, Paul W. Noble, Niko Van De Velde, Liam Hudson, Raoul Benlloch, Satish S. Singh, Karan Verma, D Laba, Jack Carmichael, Peter Richardson, Graham Wilson, Ricky Lewis, Karthik Surendran, Essam El-Damatty, Sarada Gurung, Ilona Raulusaite, Nabua Gerstina, C. G. Rochester, Rai Kuldip, Andrew M. Lindner, Therese Murray, Vivek Chitre, Roshan Lal, Sarah Downey, Vamsi Velchuru, Kamal Aryal, Raman Guruswamy, Kirosh Shankar, Helen Porter, Matthew G. Tutton, Helen Agostini, Simon P. Fletcher, Richard Wharton, S Hutchinson, Bala Maiya, Richard Howard-Griffin, Michael Crabtree, Vlad Kushakovsky, Abdel Omer, Senthil Nadarajavan, Stephanie Bell, Vishal Patil, Asif Jah, Razeen Mahroof, Nicholas Watson, John Tansley, Gareth Moncaster, Neil Flint, Andrew G Miller, Marcus de Wood, Andreou Prematie, Sally Roth, Sarah Bowery, Dawn Hales, Tanuja Shah, Gillian Tierney, C. Morris, Syed Yusuf Iftikhar, Amit Shukla, Grainne O'Dwyer, Adam Wolverson, Ferdinand Adams, Laura Perrin-Brown, T. R. White, Sarah Beavis, Victoria Banks, J F Abercrombie, J P Molé, Avninder Chana, Ayan Banerjea, David J. Humes, Rajpal Dhingsa, John Paul Wells, Stephanie Brown, Kenneth Adegoke, Barclay Tofte, Ana Alegria, Nat Natarajan, Mansoor Akhtar, Samer Doughan, John Mackinnon, Biju Aravind, Esther Cook, Mark Snazelle, Matt Gardner, Lee Baldwin, Simon Bailey, G. Lawton, Niranjan Shridhar Divekar, Neil Kukreja, Mansoor Sange, Mark Watson, Mallikarjunappa Satisha, Michael Protopapas, Zakaulla Belagodu, Shameem Sarfi, P. Raju, Brenda Stacey, Tim Campbell-Smith, Simon J. Parrington, Somi Desikan, Andrew Brennan, J Griffith, Steve Fletcher, Catherine Farrow, Stewart Prestwich, Laura A. Graham, Martin Northey, Jay Gokhale, Frances Mosley, Peter Alexander, Abhiram Sharma, Will Brady, John L. Hopper, Oliver W. Hill, Sandeep Varma, Christopher Macklin, Alastair Rose, Harjeet Singh Narula, Sarah Buckley, Karen Simeson, Kevin Sim, Michael Chadwick, Preeti Kuduvalli, Susan Dowling, Amanda McCairn, Lawrence Wilson, Dale Vimalchandran, Anita Jhamatt, Nicole Robin, Anna L. David, M. Leuwer, David Bottomley, O. Zuzan, Ingeborg Welters, Davina Ross‐Anderson, Charles H. Knowles, Nick Bunker, Ying Hu, Marta Januszewska, Phoebe Bodger, Edyta Niebrzegowska, Carmen Correia, Richard Haslop, Tom Abbott, Tabitha Tanqueray, Sanjay Wijeykoon, Susan Jain, Jens Full, Tamzin Cuming, Flora L. Bailey, Stelios Chatzimichail, Pedro Cunha, Almas Rehman, Manab Mohanty, N. J. Radford, O Mohr, Hitesh Patel, D Mateo, Ashok Raj, Michael Machesney, Nazar Abdul, Kim Jemmet, Marta Campbell, David W. Inglis, Thomas G. Parker, Thomas Medici, Peter Chan, Nathan Borgeaud, Dipankar Mukherjee, Oluremi Odejinmi, Tomas Jovaiša, Elizabeth Harwood, Ramani Moonesinghe, Jonathan McCullough, Jigna Modha, Sanjiv Patel, James Limb, Sheshagiri Bengeri, Amir Rafi, Elizabeth J. Hall, Julia Brown, Bruce Gibson, Una McNelis, Mike Bradburn, Maria Lawson, Sara Pick, Matthew Gaughan, David Browell, Vanessa Linnett, Jenny Ritzema, Paul O’Loughlin, Sean Cope, John D. Corson, Alistair Roy, Julie Furneval, A. M. Holtham, Sophie Noblett,

Background Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. Methods We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency ...

Elsevier BV

Revisão Revisado por pares

R.W. Harrington,

... S. H., Weller, E. B., Hughes, C. W., Welter, R. A. & Bolte, K. (1987) Depression in prepubertal ...

Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes

1992 - Wiley | Journal of Child Psychology and Psychiatry

Artigo

Peter Sandercock, Janet Darbyshire, David L. DeMets, Robert Fowler, David G. Lalloo, Mohammed Munavvar, Adilia Warris, Janet Wittes, Andrea Cradduck-Bamford, Jill Barton, Ahmet Başoğlu, R. Dale Brown, Wojciech Brudlo, É. Denis, Lucy Fletcher, Sarah Howard, K. Taylor, Guanglin Cui, Belinda Goodenough, Alexander H. King, M Lay, David W. Murray, William Stevens, Karl Wallendszus, R. Wels, Charles Crichton, Jim Davies, Raph Goldacre, Charlie Harper, F. I. KNIGHT, Miles A. Nunn, Hizni Salih, John J. Welch, Mohamed A. Zayed, Jonathan D. Wiles, GRANT P. BAGLEY, Scott J. Cameron, Samuel R. Chamberlain, Barbara Farrell, Hannah Freeman, Ann R. Kennedy, Anne Whitehouse, Stephen Wilkinson, C Wood, Christina Reith, K Davies, Heather Halls, Lisa Holland, Rory Truell, Ken Wilson, L. Howie, Michael P. Lunn, Philip T. Rodgers, Louise Bowman, Fang Chen, Robert Clarke, Michelle Goonasekara, William G. Herrington, P. G. Judge, S. Ng, D. Preiss, Emily Sammons, Doreen Zhu, Amanda Barnard, J. Beety, Chris Birch, Morwenna Brend, Emma S. Chambers, Lucy C. Chappell, Sarah Crawshaw, Charles G. Drake, Hayley Duckles-Leech, James E. Graham, T Harman, H. Harper, S Lock, Kaatje Lomme, Nigel A.J. McMillan, Ian Nickson, Udeme Ohia, Eleanor OKell, Vanessa Poustie, Soya S. Sam, Peter J. Sharratt, John Sheffield, Herbert B. Slade, William van’t Hoff, Samantha Walker, James D Williamson, Anthony De Soyza, Paul Dimitri, Saul N. Faust, Nicholas R. Lemoine, Jane Minton, Kimberly Gilmour, Karen Pearson, Charlotte Armah, Danielle Campbell, Hugo Ten Cate, Andrew N. Priest, E Thomas, R. Usher, Graham Johnson, M Logan, Steven Pratt, Anna Price, K. A. Shirley, E. Walton, Petal Petersen Williams, Fiona Yelnoorkar, Jane Hanson, Helen Membrey, Liz Gill, Antonio Oliver, Swati Das, Simon Murphy, Mihaela Sutu, Joanne Collins, H. Monaghan, A. Unsworth, Simon Beddows, Kerry Barker-Williams, Shawn Dowling, Kristen Gibbons, Kathleen H. Pine, A. Asghar, Paula Aubrey, Dawn Beaumont-Jewell, Kieran Donaldson, Timothy Skinner, Ji Luo, Nhlanhla Mguni, Natasha Muzengi, Richard J. Pleass, Emma Wayman, Anna‐Britt Coe, James W. Hicks, Michael Hough, Chris Levett, Alexandra L. Potter, Julie Taylor, Mary Dolman, Lee Gerdes, Claire Hall, Trevor Lockett, David A. Porter, John R. Bartholomew, Lucy Dowden, C. Rook, James B. Walters, Erika Denton, Heather Tinkler, Adam C. Alexander, Helen Campbell, K Chapman, Anthony J. Hall, Anthony Rodgers, Peter Boyle, Matthew Brookes, Claire Callens, Helen Duffy, Cameron Green, Kate Hampshire, Stephanie L. Harrison, Jeremy Kirk, Misbah Naz, Linda Porter, Pablo Ryan, Jacintha Shenton, John R. Warmington, M. R. Amezaga, Pamela Dicks, Joanne Goodwin, Helen Hodgson, SL Jackson, Miranda Odam, D. Williamson, Heather Pinches, P. Bowker, Victoria Byrne-Watts, G Chapman, Glen Coleman, J.D. Gray, Andrew Rees, Nancy Mather, Tom Denwood, David A Harrison, Grace Turner, Johanna Bruce, C Arkley, Sarah Rees, J Alin, L Anguvaa, Joseph Bae, Gabriela Bega, Simon Bowman, Arup Chakraborty, Elizabeth L. Clare, Simon W. Fox, Samantha Franklin, Sarah L. George, Lee How, Marcus P. Kennedy, Judy Mead, Louise Mew, Dushyant Mital, Lisa Moran, Esther Mwaura, Mala Nathvani, Alastair Rose, Diane Scaletta, Shivani A. Shah, Loria Siamia, Oliver Spring, Stephanie Sutherland, François Teasdale, Sameer Velankar, L. Wren, Francesca Wright, M. Abouzaid, Christopher Adams, Ahmad Al Aaraj, Osama Alhabsha, Mohammad Ali, Emilio Aliberti, Dennis W. Ashley, Daniel Barker, Humayun Bashir, Bridget Campbell, A. Chilvers, Ezomike Chinonso, Victoria Collins, E B Connell, Kevin Conroy, Eline G. M. Cox, Jennifer Deane, J. Dunleavy, Isabelle Fenner, Chun Loo Gan, Isha Garg, Catherine Gibb, Sharon Gowans, William Hartrey, Félix Manuel Francisco Hernández, Joseph Jacob, Vidhya Jagannathan, Vandana Jeebun, Sandra Jones, Michael Khan, Yuan Jun Koe, D. Leitch, Lessica M Magnaye, T. Mane, Thamani Mazhani, Nolan McDonnell, Mohamed Nafei, Becky Baltich Nelson, L. Poole, Elizabeth Poyner, Scott F. Purvis, J Quigley, Alex Ramshaw, Harmony R. Reynolds, Lisa A. Robinson, Ian Louis Ross, R Salmon, Lois E. Shepherd, Elaine Siddle, S Sinclair, Matthew Smith, R. Sathish Srinivasan, Kirsten Stewart, Rachel A. Taylor, Graham R. Wallace, Shuang Wang, Lea C. Watson, Maria Weetman, Bill Wetherill, Sarah H. Wild, K. Win, Timothy Felton, Simon Carley, Robert Lord, Andrew Ustianowski, Mustafa Abbas, Aqsa Rasheed, Thomas Abraham, Sandeep Aggarwal, Asim A. Ahmed, Suha Akili, Paul Alexander, Alison Allanson, Bashar Al‐Sheklly, Deepak Arora, Miriam Avery, Cristina Avram,

Abstract Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual ...

Nature Portfolio

Artigo

Kristine M. Erlandson, Linda N. Geng, Caitlin Selvaggi, Tanayott Thaweethai, Peter Chen, Nathan Erdmann, Jason D. Goldman, Timothy J. Henrich, Mady Hornig, Elizabeth W. Karlson, Stuart D. Katz, Chun Kim, Sushma K. Cribbs, Adeyinka O. Laiyemo, Rebecca Letts, Janet Lin, Jai Marathe, Sairam Parthasarathy, Thomas F. Patterson, Brittany D. Taylor, Elizabeth R. Duffy, Monika Haack, Boris Jülg, Gabrielle Maranga, Carla Hernandez, Nora G. Singer, Jenny E. Han, Priscilla Pemu, Hassan Brim, Hassan Ashktorab, Alexander W. Charney, Juan P. Wisnivesky, Jenny J. Lin, Helen Y. Chu, Minjoung Go, Upinder Singh, Emily B. Levitan, Paul Goepfert, Janko Ž. Nikolich, Harvey Hsu, Michael J. Peluso, J. Daniel Kelly, Megumi J. Okumura, Valerie J. Flaherman, John G. Quigley, Jerry A. Krishnan, Mary Beth Scholand, Rachel Hess, Torri D. Metz, Maged M. Costantine, Dwight J. Rouse, Barbara S. Taylor, Mark P. Goldberg, Gailen D. Marshall, Jeremy P. Wood, David E. Warren, Leora I. Horwitz, Andrea S. Foulkes, Grace A. McComsey, Jeffrey P. Burns, Serena Spudich, L. Charles Bailey, Mine S. Cicek, Melissa Cortez, Felicia Davis Blakley, Andrea S. Foulkes, David C. Goff, Stuart D. Katz, Jessica Lasky‐Su, Torri D. Metz, Lisa T. Newman, Igho Ofotokun, Sudha Seshadri, Melissa S. Stockwell, James R. Stone, Brittany D. Taylor, PJ Utz, Neely Williams, Hassan Ashktorab, Jeannette M. Beasley, Karyn Bishof, Yu Chen, Lori B. Chibnik, Dani Dumitriu, Jennifer Frontera, Paul Goepfert, Sylvie Goldman, Stephen M. Hewitt, Matthew J. Huentelman, Barbara I. Karp, Jerry A. Krishnan, Sarah Laury, Bruce D. Levy, Janko Nikolich‐Žugich, Margaret J. Ochocinska, Laura Pace, Alice Perlowski, William Reeves, Juan C. Salazar, Lumy Sawaki-Adams, Sujata Thawani, Hannah Valantine, Drenna Waldrop, Dana L. Wolff‐Hughes, Marta Cerda, Victor H. Clash, Felicia Davis Blakley, Brittany Taylor, Mike Zissis, Teresa Akintonwa, Frank Blancero, Heather-Elizabeth Brown, Megan Carmilani, Debra Copeland, Yvonka Hall, Kevin Kondo, Lydia Lerma, Jacqui Lindsay, Heather Marti, Christine Maughan, Tony Minor, Hyatt Vincent, Andra L. Blomkalns, David Warburton, Ingrid V. Bassett, Rebecca G. Clifton, Hannah Davis, Nathan Erdmann, Valerie J. Flaherman, Margot Gage Witvliet, Mark P. Goldberg, Zoe Guan, Jonathan D. Klein, Gregory Laynor, Thomas F. Martínez, Rebecca McGrath, Sairam Parthasarathy, Priscilla Pemu, Erika B. Rosenzweig, Jacqueline Rutter, Hugh Auchincloss, Diana W. Bianchi, Jennifer Moss Breen, Paul M. Brennan, Jeffrey P. Burns, Nakela L. Cook, Felicia Davis Blakley, Betty Diamond, Mitchell S.V. Elkind, Lee Fleisher, Andrea S. Foulkes, Gary H. Gibbons, Laurie Gutmann, Michael F. Iademarco, Stuart D. Katz, Walter J. Koroshetz, Eldrin F. Lewis, Peter Marks, Hilary D. Marston, Mitchell G. Miglis, Lisa A. Newman, Tracy L. Nolen, Carlos A. Pardo, Amy Patterson, Samuel F. Posner, Wendy S. Post, Serena Spudich, Clinton B. Wright, Heather E. Yates, Kanecia O. Zimmerman, Gabriel Anaya, Audie A. Atienza, L. Charles Bailey, R. Graham Barr, Lisa G. Berdan, Andra L. Blomkalns, Melissa L. Bondy, Hassan Brim, Jeffrey P. Burns, Alexander W. Charney, Benjamin K. Chen, Mine S. Cicek, John F. Crary, Dawood Darbar, Kathi Diviak, Ray F. Ebert, Jamie Elifritz, Robert L. Ferrer, Joshua P. Fessel, Aloke V. Finn, Thomas J. Flotte, Paul Fontelo, Andrea S. Foulkes, Emily J. Gallagher, Maria Laura Gennaro, Mary Groesch, Rachel S. Gross, Melissa Haendel, James R. Heath, Rachel Hess, Stephen M. Hewitt, Sally Hodder, Carol R. Horowitz, Leora I. Horwitz, Vanessa L. Jacoby, Sarah E. Jolley, Suzanne E. Judd, Bill G. Kapogiannis, Elizabeth W. Karlson, Barbara I. Karp, Stuart D. Katz, Rainu Kaushal, Lawrence C. Kleinman, Jerry A. Krishnan, Sweta Ladwa, Craig Lefebvre, Lei Lei, Emily B. Levitan, Bruce D. Levy, Daniel Liu, Jeffrey N. Martin, Grace A. McComsey, Robin J. Mermelstein, Torri D. Metz, Lucio Miele, Sindhu Mohandas, Janet Mullington, Shawn N. Murphy, Jane W. Newburger, Lisa A. Newman, Margaret J. Ochocinska, Igho Ofotokun, Princess U. Ogbogu, Michelle Olive, Sairam Parthasarathy, Amy Patterson, Thomas F. Patterson, Gail D. Pearson, Priscilla Pemu, J. Zachary Porterfield, Antonello Punturieri, R. Ross Reichard, Jane E.B. Reusch, Kyung E. Rhee, Kathleen E. Rodgers, Juan C. Salazar, Amy L. Salisbury, Lumy Sawaki-Adams, Lisa Schwartz-Longacre, Sudha Seshadri, Howard D. Sesso, Eyal Shemesh, Allan C. Shipp, Upinder Singh, Jessica Snowden, Serena Spudich, Melissa S. Stockwell, James R. Stone, Jun Sun, Mehul S. Suthar, David M. Systrom, Brittany Taylor, Stephen N. Thibodeau, Andrea B. Troxel, PJ Utz, Tiffany Walker, David Warburton, Gail Weinmann, Neely Williams, Dana L. Wolff‐Hughes, John C. Wood, Khamal Anglin, Emilia Bagiella, Ryan C. Branski, Rodica Pop‐Busui, Marissa Diggs, Vivian S. Gainer, Sunanda Gaur, Linda N. Geng, Sarah E. Jolley, Sarah Laury, Jai Marathe, Lisa McCorkell, Jarrod Mosier, Binita Shah, Dimpy P. Shah, Tiffany Walker, Peter Whitesell, Natasha Altman, Tellen D. Bennett, Soham Dasgupta, Marissa Edminston, Tyler Gustafson, François Haddad, Jennifer Hossain, Priscilla Y. Hsue,

There are currently no validated clinical biomarkers of postacute sequelae of SARS-CoV-2 infection (PASC).

American College of Physicians

Artigo

T. Velasquez, Gina Mackey, J. Lusk, Ursula G. Kyle, Taylor Fontenot, Peter Marshall, L. S. Shekerdemian, Jorge Coss‐Bu, A. Nishigaki, Tomoaki Yatabe, T. Tamura, Koichi Yamashita, M. YOKOYAMA, Juan Carlos Ruiz‐Rodríguez, B. Encina, R. Belmonte, I. Troncoso, Pau Micó Tormos, Mar Riveiro‐Barciela, Javier Baena-, Álex Sánchez-Plà, J. Bañeras, Joan F. Andrés-Cordón, Nilüfer Ekşi Duran, A. Ruiz, J. Caballero, X. Nuvials, Joan Sabater‐Riera, J Serra, A Rutten, S. N. M. van Ieperen, E. P. H. M. Der Kinderen, T. Van Logten, L. Kovacikova, P. Skrak, Martin Zahorec, Ursula G. Kyle, A. Akcan-Arikan, J. C. Silva, Gina Mackey, J. Lusk, Michelle Goldsworthy, L. S. Shekerdemian, Jorge Coss‐Bu, David L. Wood, David A Harrison, Roger Parslow, Peter J. Davis, Joseph M. Pappachan, S. Goodwin, Padmanabhan Ramnarayan, S. Chernyshuk, H. Yemets, Volodymyr Zhovnir, S. M. Pulitano’, S. De Rosa, Aldo Mancino, Gianluca Villa, F. Tosi, Paola Franchi, G. Conti, Binisha Patel, Hnin Khine, Atul K. Shah, Deborah Sung, Leif Singer, S. Haghbin, Soroor Inaloo, Zahra Serati, M. Idei, T. Nomura, Natsuhiro Yamamoto, Y. Sakai, T. Yoshida, Y. Matsuda, Y. Yamaguchi, S. Takaki, O. Yamaguchi, T. Goto, N. Longani, Shivanand Medar, I. R. Abdel-Aal, Alaa Adawy, H. M. E. H. Mohammed, A. N. Mohamed, Selina M. Parry, Laura D. Knight, L. Denehy, Ben Morton, Claire Baldwin, D. Sani, G. Kayambu, V. Z. M. da Silva, Pimsiri Phongpagdi, Z. A. Puthucheary, Catherine L. Granger, Jessica Rydingsward, Clare Horkan, Kenneth B. Christopher, David McWilliams, Charlotte Jones, Ellie Reeves, G. Lawrence Atkins, Catherine Snelson, L. M. Aitken, Janice Rattray, Justin Kenardy, A. M. Hull, Amanda Ullman, Robyne Le Brocque, Marion Mitchell, Chelsea Davis, Bonnie Macfarlane, Jader Cunha de Azevedo, Leonardo Lima Rocha, Flávia Fernandes Manfredi de Freitas, A. M. A. Cavalheiro, Neide Marcela Lucinio, M. S. Lobato, Georg Ebeling, A. Kraegpoeth, Eva Lærkner, I. De Brito-Ashurst, C. White, S. Gregory, L. Forni, E. Flowers, Alexandra Curtis, C.-A. Wood, Katherine Lai-Sheung Siu, Kumaresh Venkatesan, Junalia Muhammad, Linda Ng, Edwin Seet, N. Baptista, A. Escoval, Esmael Tomás, R. Agrawal, R. Mathew, Amit Varma, Eftychia Dima, E. Charitidou, Efstathia Perivolioti, M. Pratikaki, Charikleia S. Vrettou, Achilleas Giannopoulos, Spyros Zakynthinos, Christina Routsi, Enora Atchade, S. Houzé, S. Jean-Baptiste, G. Thabut, Claire Genève, Sébastien Tanaka, Brice Lortat‐Jacob, P. Augustin, Mathieu Desmard, P. Montravers, Francisco Molina, S. Barbadillo, Rodolfo Alejandro, Francisco Álvarez-Lerma, J. Vallés, R. M. Catalán, Esperanza Marbella Palencia Gutiérrez, A. Jareño, R. Granada, M. L. Ignacio, Na Cui, D. Liu, Hui Wang, Longxiang Su, H Qiu, Ruijiang Li, K. Jaffal, Anahita Rouzé, Julien Poissy, Boualem Sendid, Saad Nseir, E. Paramythiotou, M. Rizos, F. Frantzeskaki, Anastasia Antoniadou, S. Vourli, L. Zerva, Apostolos Armaganidis, Joan Sabater‐Riera, Jens Gottlieb, M. Greer, Olaf Wiesner, M. Martínez, Mauricio Acuña, Jordi Rello, T. Welte, Enora Atchade, T. Mignot, S. Houzé, S. Jean-Baptiste, G. Thabut, Brice Lortat‐Jacob, Sébastien Tanaka, P. Augustin, Mathieu Desmard, P. Montravers, Sabri Soussi, Emmanuel Dudoignon, Axelle Ferry, Maïté Chaussard, Mourad Benyamina, A. Alanio, S. Touratier, Marc Chaouat, Matthieu Lafaurie, Maurice Mimoun, A. Mebazaa, M. Legrand, M. A. Sheils, C. Patel, L. Mohankumar, Nasreen Akhtar, S. K. Pacheco Noriega, N. Navarrete Aldana, Jacquelyn León, J. Durand Baquero, F. Fernández Bernal, Elahe Ahmadnia, J. S. Hadley, M. Millar, D. Hall, Heather Hewitt, Hisakazu Yasuda, M. Sanui, Takashi KOMURO, S. Kawano, K. Andoh, H. Yamamoto, E. Noda, J. Hatakeyama, Naohiro Saitou, H. Okamoto, A. Kobayashi, T. Takei, S. Matsukubo, H. B. Rotzel, Ainhoa Serrano, D. Aguillón Prada, M. Rodriguez Gimillo, O. Diaz Barinas, M. L. Blasco Cortes, José Franco, J. M. Segura Roca, Arturo Carratalá, Bruno Gonçalves, R. Turon, A. Mendes, Félix A. Miranda, P. J. Mata, Daniel D. Cavalcanti, Nancy Rozo Melo, P. Lacerda, Pedro Kurtz, Cássia Righy, L. E. de la Cruz Rosario, S. P. Gómez Lesmes, J. C. García Romero, A. N. García Herrera, E. D. Díaz Pertuz, M. J. Gómez Sánchez, E. Regidor Sanz, J. Barado Hualde, A. Ansotegui Hernández, J. M. Guergué Irazabal, Věra Špatenková, Ondřej Bradáč, P. Suchomel, T. Urli, E. Heusch Lazzeri, Raffaele Aspide, Marco Zanello, L. Perez-Borrero, J. M. Garcia-Alvarez, M. D. Arias-Verdu, E. Aguilar-Alonso, Ricardo Rivera-Fernández, J. Mora-Ordoñez, C. De La Fuente-Martos, E. Castillo-Lorente, F. Guerrero-Lopez, S. P. Gómez Lesmes, L. E. De la Cruz Rosario, E. D. Díaz Pertuz, A. Ansotegui Hernández, J. C. García Romero, M. J. Gómez Sánchez, A. N. García Herrera, J. Roldán Ramírez,

Comprised of multi-disciplinary stakeholders - frontline staff and patient representative. A brainstorming storming process identified various barriers to optimal mobilisation. Quality improvement tools such as Affinity diagram

Springer Nature

Artigo

Zoe Swank, Ella Borberg, Yulu Chen, Yasmeen Senussi, Sujata Chalise, Zachary Manickas-Hill, Xu G. Yu, Jonathan Z. Li, Galit Alter, Timothy J. Henrich, Joanna Kelly, Rebecca Hoh, Sarah A. Goldberg, Steven G. Deeks, Jeffrey N. Martin, Michael J. Peluso, Aarthi Talla, Xiaojun Li, Peter J. Skene, Thomas F. Bumol, Troy R. Torgerson, Julie Czartoski, M. Juliana McElrath, Elizabeth W. Karlson, David R. Walt, Rachael Abraham, Arijan Ager, Franchesca A. Aguilar, Ghazal Ahmadi-Izad, Dilshad R. Ahmed, Alicarmen Alvarez, Blake Anderson, Walter D. Asencios, Mary Atha, Casey L. Beaty, Brahmchetna Bedi, Jasmine A. Berry, Donchel Boone, Mary Bower, J. Douglas Bremner, Corbin Brent, Ke’Ara Brown-Smith, Rachel Bull, Patricia A. Bush, Gustavo Capo, Kelechi Carl-Igwe, Calista Chitadze, Nachi Chukwumerije, Erna Clyburn, Shelby Collins, Julie Costello, Grace Couture, Angel Craft, Sushma K. Cribbs, Xiangqin Cui, Annette Dandy, Carlos del Rı́o, Rijalda Jasarevic, Joshua F. Detelich, Cartia Dixon, Jeanne Dow, D.J. Doyle, Jannah Elchommali, Carmel Ibeawuchi, Imani Elsey, Rebecca Fineman, Anyssa G. Francis, Nicole Franks, Julia W. Gallini, Jennifer C. Gander, Natalie Gray, Ash Grimes, Evan Gutter, Jenny E. Han, Tina P. Hang, Jess Harding, Liliana Hernández, Lauren N. Hewitt, Carla Holloway, Alex F. Hudgins, Christopher Huerta, Carmel Ibeawuchi, Cynthia Ifejika, Ketteria D. Ingram, Vidhi Javia, Mykayla Jeter, Brandi Johnson, Yasha Joseph, Monica Juarez, Dana Kajan, Lana Khalil, Caitlin M. Kirkpatrick, Dean J. Kleinhenz, Imanii Kolailat, Athena Koumanelis, Alexandra Koumanelis, Rebecca Kozoman, Shilpa Krishnan, Jordi Lainez, Brianna Lawrence, Matthew A. Lee, Jose D. Leon, Valerie Lew, Kennedy C. Lewis, Matthew Litvack, Mara Maroney, Cheryl L. Maier, Nour Makkaoui, Vincent C. Marconi, Christopher F. Martin, Monica Martinez, Loice Mbogo, Atuarra McCaslin, J. McIntyre, Abeer Moanna, Miranda Montoya, Elena Martín Morales, Caitlin A. Moran, Jan Morgan‐Billingslea, Calista Murray, R. Nelson, Robert B. Neuman, Nguyen Tran Tuan, Ighovwerha Ofotokun, Elizabeth I. Ojemakinde, B. Ojoawo, Eileen Osinski, Sofia Oviedo, Bernadine Panganiban, Yolanda Paredes-Gaitan, Rachel E. Patzer, Priscilla Pemu, Michael Prude, Kazi Mizanur Rahman, Grace Ramakrishnan, Paulina A. Rebolledo, Marjorie Roberts, Keysha Robinson, Chantrice Rogers, Nadine Rouphael, Charles Searles, Anand Shah, Marni Segall, Renata Michelle Shaw, Ruvina Silva, Claire L. Simpson, Krystal Simpson-Derrell, Talib Sirajud-Deen, Veronica E. Smith, Andre Stringer, Jacob Stroud, Mehul S. Suthar, Cory Sylber, Ashley Sylvera, Tehquin Tanner, Larissa Teunis, Maliya Tolbert, Kodasha M. Thomas, Sierra G. Thompson, Kehmia Titanji, Christopher Toy, Jessica Traenkner, Alex Truong, Kristen Unterberger, Viola Vaccarino, Kris Varney, Kartavya J. Vyas, Kurt Vyas, Tiffany Walker, Max Walkow, Dongli Wang, Tamara Wesley, Zanthia Wiley, Erika Wimberly, Juton Winston, Terra J. Winter, Cherry Wongtrakool, Masanori Aikawa, George A. Alba, Taing N. Aung, Lindsey R. Baden, Gaston Baslet, Ingrid V. Bassett, Lindsey Bennett, Shamik Bhattacharyya, Deborah Blazey-Martin, Julie E. Buring, R. Elaine Cagnina, Long‐Qing Chen, Cheryl R. Clark, Pieter A. Cohen, Ai‐ris Y. Collier, Charles A. Czeisler, Elizabeth R. Duffy, Peter Estill, Tamara G. Fong, Elizabeth Gay, Maher Ghamloush, Leo C. Ginns, Monika Haack, Jennifer S. Haas, Naomi M. Hamburg, Kristine Hauser, Janice John, Michael R. Jordan, Boris D. Juelg, Diane G. Kanjilal, Arthur Y. Kim, Elizabeth B. Klerman, Misaki Kobayashi, Laura Kogelman, Daniela Lamas, Bruce D. Levy, Nomi C. Levy‐Carrick, Greg Lewis, Jason H. Maley, JoAnn E. Manson, Jai Marathe, Janet M. Mullington, George O'connor, Bisola O. Ojikutu, Roy H. Perlis, Yuri Quintana, Susan Redline, Elijah J. Remis, Jonathan Rosand, Howard D. Sesso, Lynn Shaughnessy, Fitzgerald M. Shepherd, Scott D. Solomon, Jeffrey A. Sparks, Lia L. Spencer, Kathryn E. Stephenson, David M. Systrom, Robert J. Thomas, Phyo Phyo Min Thu, Amberly Ticotsky, Robert Carreras‐Torres, Zachary S. Wallace, David R. Walt, Honorine Ward, George Washko, Maureen Whittelsey, Rebecca Wiener, Charles T. Williams, Dean Xerras, Haihua Zhang, Danielle Zionts, Donna Armstrong, Susan E. Binkley, Kenneth Blackwell, Todd T. Brown, Thomas W. Carton, Annalia Causey, Felice Cook, Casey L. Daniel, Paula Datri, Julio Domingo, Conner Donahue, Maitlyn Eady, Jeffrey C. Edberg, Nathaniel Erdmann, Jyotsna Fuloria, Noah Garcia-McClaney, Melissa Garner, Mark N. Gillespie, Brandon Gray, Michael Hagensee, Wanda Hall, Jamie Hansel, Cady Hart, Camden L. Hebson, Bertha Hidalgo, Kaylen Holtzapfel, Alexis Jinright, Suzanne E. Judd, Teri Kennedy, Leigh Kirkwood, Cathryn Leggio, Emily B. Levitan, Megan Maier, Patricia McCormack, Lucio Miele, Kevin Mitchell, Aoyjai P. Montgomery, Myriam Peralta‐Carcelen, Allen Perkins, Juan P. Pilco, Leigh Powell, Rachael Shevin, Sidney Skipworth, Leah Spurgeon, Erica Sutherland, Alan T. Tita, Amber Trauth, Siobhan Trotter,

To determine the proportion of individuals with detectable antigen in plasma or serum after SARS-CoV-2 infection and the association of antigen detection with postacute sequelae of COVID-19 (PASC) symptoms.

Elsevier BV

Artigo Acesso aberto Revisado por pares

Dahlia Tharwat, Marion Trousselard, Mélanie Balès, Anne‐Laure Sutter‐Dallay, Dominique Fromage, Élisabeth Spitz, D. Dallay, Thierry Harvey, Eric Welter, F. Coatleven, Lydie Chérier, Frédérique Teissèdre, Jean‐Luc Pouly, Frédéric Dutheil, Anaïs M. Duffaud,

The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological ...

Tópico(s): Infant Development and Preterm Care

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