Stella E. Hughes, Tim Spelman, Orla Gray, Cavit Boz, Maria Trojano, Alessandra Lugaresi, Guillermo Izquierdo, Pierre Duquette, Marc Girard, François Grand’Maison, Pierre Grammond, Celia Oreja‐Guevara, Raymond Hupperts, Roberto Bergamaschi, Giorgio Giuliani, Jeannette Lechner‐Scott, Michael Barnett, Maria Edite Rio, Vincent Van Pesch, Maria Pia Amato, Gerardo Iuliano, Mark Slee, Freek Verheul, Edgardo Cristiano, Ricardo Fernández‐Bolaños, Dieter Poehlau, Maria Luisa Saladino, Norma Deri, José Antonio Cabrera-Gómez, Norbert Vella, Joseph Herbert, Eli Skromne, Aldo Savino, Cameron Shaw, Fraser Moore, Steve Vucic, Tatjana Petkovska‐Boskova, Gavin McDonnell, Stanley Hawkins, Frank Kee, Helmut Butzkueven, Damiano Paolicelli, Guglielmo Lucchese, Pietro Iaffaldano, Cees Zwanikken, Giovanna De Luca, V. Di Tommaso, D. Travaglini, Erika Pietrolongo, Maria di Ioia, D. Farina, Luca Mancinelli, Mark Marriott, Trevor J. Kilpatrick, John King, Anneke van der Walt, Olga Skibina, Jodi Haartsen, Beatriz Chamorro, Thor Petersen, Elisabetta Cartechini, Eugenio Pucci, David William, Lisa Dark, Marcela Fiol, Jorge Correale, Célica Ysrraelit, Leontien Den Braber‐Moerland, G. Jaacks, Alfredo Laffue, María Fernanda Páez, Daniel Muñoz, Walter Oleschko Arruda, Mark Paine, Malcolm Vella, Vetere Santiago,
Background: Several studies have shown that pregnancy reduces multiple sclerosis (MS) relapses, which increase in the early postpartum period. Postpartum relapse risk has been predicted by pre-pregnancy disease activity in some studies. Objective: To re-examine effect of pregnancy on relapses using the large international MSBase Registry, examining predictors of early postpartum relapse. Methods: An observational case–control study was performed including pregnancies post-MS onset. Annualised relapse ...
Tópico(s): Reproductive System and Pregnancy
2013 - SAGE Publishing | Multiple Sclerosis Journal
Liling Chen, Suizan Zhou, Zhongwei Zhang, Yan Wang, Lin Bao, Yayun Tan, Falin Sheng, Ying Song, Ran Zhang, A. Danielle Iuliano, Mark G. Thompson, Carolyn M. Greene, Jun Zhang,
Purpose We established the China Respiratory Illness Surveillance among Pregnant women (CRISP) to conduct active surveillance for influenza-associated respiratory illness during pregnancy in China from 2015 to 2018. Among annual cohorts of pregnant women, we assess the incidence of acute respiratory illness (ARI), influenza-like illness (ILI), laboratory-confirmed influenza virus infection and the seroconversion proportion during the winter influenza season. We also plan to examine the effect of influenza ...
Tópico(s): Travel-related health issues
2018 - BMJ | BMJ Open
Karen Ribbons, Patrick McElduff, Cavit Boz, Maria Trojano, Guillermo Izquierdo, Pierre Duquette, Marc Girard, François Grand’Maison, Raymond Hupperts, Pierre Grammond, Celia Oreja‐Guevara, Thor Petersen, Roberto Bergamaschi, Giorgio Giuliani, Michael Barnett, Vincent Van Pesch, Maria Pia Amato, Gerardo Iuliano, Marcela Fiol, Mark Slee, Freek Verheul, Edgardo Cristiano, Ricardo Fernández‐Bolaños, Maria-Laura Saladino, Maria Edite Rio, José Antonio Cabrera-Gómez, Helmut Butzkueven, Erik van Munster, Leontien Den Braber‐Moerland, Daniele Spitaleri, Alessandra Lugaresi, Vahid Shaygannejad, Orla Gray, Norma Deri, Raed Alroughani, Jeannette Lechner‐Scott,
Background Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. Methods Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in ...
Tópico(s): Multiple Sclerosis Research Studies
2015 - Public Library of Science | PLoS ONE
Tim Spelman, Orla Gray, Maria Trojano, Thor Petersen, Guillermo Izquierdo, Alessandra Lugaresi, Raymond Hupperts, Roberto Bergamaschi, Pierre Duquette, Pierre Grammond, Giorgio Giuliani, Cavit Boz, Freek Verheul, Celia Oreja‐Guevara, Michael Barnett, François Grand’Maison, Maria Edite Rio, Jeannette Lechner‐Scott, Vincent Van Pesch, R. Fernandez Bolanos, Shlomo Flechter, Leontien Den Braber‐Moerland, Gerardo Iuliano, Maria Pia Amato, Mark Slee, Edgardo Cristiano, Maria Luisa Saladino, Mark Paine, Norbert Vella, Krisztián Kása, Norma Deri, Joseph Herbert, Fraser Moore, Tatjana Petkovska‐Boskova, Raed Alroughani, Aldo Savino, Cameron Shaw, Steve Vucic, Vetere Santiago, Elizabeth Alejandra Bacile Bacile, Eli Skromne, Dieter Poehlau, José Antonio Cabrera-Gómez, Robyn Lucas, Helmut Butzkueven,
Previous studies assessing seasonal variation of relapse onset in multiple sclerosis have had conflicting results. Small relapse numbers, differing diagnostic criteria, and single region studies limit the generalizability of prior results. The aim of this study was to determine whether there is a temporal variation in onset of relapses in both hemispheres and to determine whether seasonal peak relapse probability varies with latitude.The international MSBase Registry was utilized to analyze seasonal ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2014 - Wiley | Annals of Neurology
Ali Ghasemzadeh, Mary P. Galea, Andrew Nunn, Maya G. Panisset, Xiaofang Wang, Sandra Iuliano, Steven K. Boyd, Mark R. Forwood, Ego Seeman,
Modelling and remodelling adapt bone morphology to accommodate strains commonly encountered during loading. If strains exceed a threshold threatening fracture, modelling-based bone formation increases bone volume reducing these strains. If unloading reduces strains below a threshold that inhibits resorption, increased remodelling-based bone resorption reduces bone volume restoring strains, but at the price of compromised bone volume and microstructure. As weight-bearing regions are adapted to greater ...
Tópico(s): Bone health and osteoporosis research
2020 - Elsevier BV | Bone
Concetta Cuozzo, Antonio Porcellini, Tiziana Angrisano, Annalisa Morano, Bongyong Lee, Alba Di Pardo, Samantha Messina, Rodolfo Iuliano, Alfredo Fusco, Maria Rosaria Santillo, Mark T. Muller, Lorenzo Chiariotti, Max E. Gottesman, Enrico V. Avvedimento,
To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem repeated green fluorescent protein (GFP) genes (DR-GFP). A total of 2%–4% of the cells generated a functional GFP by homology-directed repair (HR) and gene conversion. However, ~50% of these recombinants expressed GFP poorly. Silencing was rapid and ...
Tópico(s): Genomics and Chromatin Dynamics
2007 - Public Library of Science | PLoS Genetics
Tamasine Stewart, Tim Spelman, Eva Havrdová, Dana Horáková, Maria Trojano, Guillermo Izquierdo, Pierre Duquette, Marc Girard, Alexandre Prat, Alessandra Lugaresi, François Grand’Maison, Pierre Grammond, Patrizia Sola, Vahid Shaygannejad, Raymond Hupperts, Raed Alroughani, Celia Oreja‐Guevara, Eugenio Pucci, Cavit Boz, Jeannette Lechner‐Scott, Roberto Bergamaschi, Vincent Van Pesch, Gerardo Iuliano, Cristina Ramo‐Tello, Bruce Taylor, Mark Slee, Daniele Spitaleri, Franco Granella, Freek Verheul, Pamela McCombe, Suzanne Hodgkinson, Maria Pia Amato, Steve Vucic, Orla Gray, Edgardo Cristiano, Michael Barnett, José Luis Sánchez-Menoyo, Erik van Munster, María Laura Saladino, Javier Olascoaga, Julie Prévost, Norma Deri, Cameron Shaw, Bhim Singhal, Fraser Moore, Csilla Rózsa, Neil Shuey, Olga Skibina, Ilya Kister, Tatjana Petkovska‐Boskova, Radek Ampapa, Allan G. Kermode, Helmut Butzkueven, Vilija Jokubaitis, Tomáš Kalinčík,
This study evaluated the effect of relapse phenotype on disability accumulation in multiple sclerosis.Analysis of prospectively collected data was conducted in 19,504 patients with relapse-onset multiple sclerosis and minimum 1-year prospective follow-up from the MSBase cohort study. Multivariable linear regression models assessed associations between relapse incidence, phenotype and changes in disability (quantified with Expanded Disability Status Scale and its Functional System scores). Sensitivity ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2016 - SAGE Publishing | Multiple Sclerosis Journal
Produção Nacional
Revisado por pares
Juan Ignacio Rojas, Liliana Patrucco, Maria Trojano, Alessandra Lugaresi, Guillermo Izquierdo, Helmut Butzkueven, Vilija Jokubaitis, Pierre Duquette, Marc Girard, François Grand’Maison, Pierre Grammond, Celia Oreja‐Guevara, Raymond Hupperts, Cavit Boz, Thor Petersen, Roberto Bergamaschi, Giorgio Giuliani, Jeannette Lechner‐Scott, Michael Barnett, Maria Edite Rio, Vincent Van Pesch, Maria Pia Amato, Gerardo Iuliano, Marcela Fiol, Mark Slee, Freek Verheul, Ricardo Fernández‐Bolaños, Dieter Poehlau, Maria Luisa Saladino, Leontien Den Braber‐Moerland, Norma Deri, Walter Oleschko-Arruda, José Antonio Cabrera-Gómez, Mark Paine, Norbert Vella, Ilya Kister, Eli Skromne, Aldo Savino, Cameron Shaw, Fraser Moore, Steve Vucic, Tatjana Petkovska‐Boskova, Elizabeth Alejandra Bacile Bacile, Vetere Santiago, Edgardo Cristiano,
Limited data suggest that multiple sclerosis (MS) in Latin America (LA) could be less severe than in the rest of the world. The objective was to compare the course of MS between LA and other regions.Centers from 18 countries with >20 cases enrolled in the MSBase Registry participated. Patients with MS with a disease duration of >1 year and <30 years at time of EDSS measurement were evaluated. The MS Severity Score (MSSS) was used as a measure of disease progression. Comparisons among regions (North America, ...
Tópico(s): Systemic Lupus Erythematosus Research
2015 - SAGE Publishing | Multiple Sclerosis Journal - Experimental Translational and Clinical
Stella Hughes, Timothy Spelman, Maria Trojano, Alessandra Lugaresi, Guillermo Izquierdo, François Grand’Maison, Pierre Duquette, Marc Girard, Pierre Grammond, Celia Oreja‐Guevara, Raymond Hupperts, Cavit Boz, Roberto Bergamaschi, Giorgio Giuliani, Maria Edite Rio, Jeannette Lechner‐Scott, Vincent Van Pesch, Gerardo Iuliano, Marcela Fiol, Freek Verheul, Michael Barnett, Mark Slee, Joseph Herbert, Ilya Kister, Norbert Vella, Fraser Moore, Tatjana Petkovska‐Boskova, Vahid Shaygannejad, Vilija Jokubaitis, Gavin McDonnell, Stanley Hawkins, Frank Kee, Orla Gray, Helmut Butzkueven,
Background The Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires validation in longitudinal cohorts, we aimed to assess the utility of EDSS ranking as a predictor of 5-year outcome in the MSBase Registry. Methods Rank stability of ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2011 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
Produção Nacional
Revisado por pares
Adam Fambiatos, Vilija Jokubaitis, Dana Horáková, Eva Havrdová, Maria Trojano, Alexandre Prat, Marc Girard, Pierre Duquette, Alessandra Lugaresi, Guillermo Izquierdo, François Grand’Maison, Pierre Grammond, Patrizia Sola, Diana Ferraro, Raed Alroughani, Murat Terzi, Raymond Hupperts, Cavit Boz, Jeannette Lechner‐Scott, Eugenio Pucci, Roberto Bergamaschi, Vincent Van Pesch, Serkan Özakbaş, Franco Granella, Recai Türkoğlu, Gerardo Iuliano, Daniele Spitaleri, Pamela McCombe, Claudio Solaro, Mark Slee, Radek Ampapa, Aysun Soysal, Thor Petersen, José Luis Sánchez-Menoyo, Freek Verheul, Julie Prévost, Youssef Sidhom, Bart Van Wijmeersch, Steve Vucic, Edgardo Cristiano, Maria Luisa Saladino, Norma Deri, Michael Barnett, Javier Olascoaga, Fraser Moore, Olga Skibina, Orla Gray, Yára Dadalti Fragoso, Bassem Yamout, Cameron Shaw, Bhim Singhal, Neil Shuey, Suzanne Hodgkinson, Ayşe Altıntaş, Talal Al‐Harbi, Tünde Csépány, Bruce Taylor, Jordana Hughes, Jae-Kwan Jun, Anneke van der Walt, Tim Spelman, Helmut Butzkueven, Tomáš Kalinčík,
Background: The risk factors for conversion from relapsing-remitting to secondary progressive multiple sclerosis remain highly contested. Objective: The aim of this study was to determine the demographic, clinical and paraclinical features that influence the risk of conversion to secondary progressive multiple sclerosis. Methods: Patients with adult-onset relapsing–remitting multiple sclerosis and at least four recorded disability scores were selected from MSBase, a global observational cohort. ...
Tópico(s): Peripheral Neuropathies and Disorders
2019 - SAGE Publishing | Multiple Sclerosis Journal
Robin M. Daly, Sandra Iuliano, Jackson J. Fyfe, David Scott, Ben Kirk, Mark Q Thompson, Elsa Dent, Kate Fetterplace, Olivia Wright, Gordon S. Lynch, Jesse Zanker, S. Yu, Susan Kurrle, Renuka Visvanathan, Andrea B. Maier,
Sarcopenia and frailty are highly prevalent conditions in older hospitalized patients, which are associated with a myriad of adverse clinical outcomes. This paper, prepared by a multidisciplinary expert working group from the Australian and New Zealand Society for Sarcopenia and Frailty Research (ANZSSFR), provides an up-to-date overview of current evidence and recommendations based on a narrative review of the literature for the screening, diagnosis, and management of sarcopenia and frailty in older ...
Tópico(s): Body Composition Measurement Techniques
2022 - Springer Science+Business Media | The journal of nutrition health & aging
Concetta Cuozzo, Antonio Porcellini, Tiziana Angrisano, Annalisa Morano, Bongyong Lee, Alba Di Pardo, Samantha Messina, Rodolfo Iuliano, Alfredo Fusco, Maria Rosaria Santillo, Mark T. Muller, Lorenzo Chiariotti, Max E. Gottesman, Enrico V. Avvedimento,
[This corrects the article DOI: 10.1371/journal.pgen.0030110.].
Tópico(s): Genomics and Chromatin Dynamics
2017 - Public Library of Science | PLoS Genetics
Karl E. Cogan, Mark Evans, Enzo Iuliano, Audrey Melvin, Davide Susta, Karl Neff, Giuseppe De Vito, Brendan Egan,
Tópico(s): Sports Performance and Training
2017 - Springer Science+Business Media | European Journal of Applied Physiology
Tomáš Kalinčík, V. Vivek, Vilija Jokubaitis, Jeannette Lechner‐Scott, Maria Trojano, Guillermo Izquierdo, Alessandra Lugaresi, François Grand’Maison, Raymond Hupperts, Celia Oreja‐Guevara, Roberto Bergamaschi, Gerardo Iuliano, Raed Alroughani, Vincent Van Pesch, Maria Pia Amato, Mark Slee, Freek Verheul, Ricardo Fernández‐Bolaños, Marcela Fiol, Daniele Spitaleri, Edgardo Cristiano, Orla Gray, José Antonio Cabrera-Gómez, Vahid Shaygannejad, Joseph Herbert, Steve Vucic, Merrilee Needham, Tatjana Petkovska‐Boskova, Carmen Adella Sîrbu, Pierre Duquette, Marc Girard, Pierre Grammond, Cavit Boz, Giorgio Giuliani, Maria Edite Rio, Michael Barnett, Shlomo Flechter, Fraser Moore, Bhim Singhal, Elizabeth Alejandra Bacile Bacile, Maria Luisa Saladino, Cameron Shaw, Eli Skromne, Dieter Poehlau, Norbert Vella, Timothy Spelman, Danny Liew, Trevor J. Kilpatrick, Helmut Butzkueven,
The aim of this work was to evaluate sex differences in the incidence of multiple sclerosis relapses; assess the relationship between sex and primary progressive disease course; and compare effects of age and disease duration on relapse incidence. Annualized relapse rates were calculated using the MSBase registry. Patients with incomplete data or <1 year of follow-up were excluded. Patients with primary progressive multiple sclerosis were only included in the sex ratio analysis. Relapse incidences ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2013 - Oxford University Press | Brain
Tomáš Kalinčík, Gary Cutter, Tim Spelman, Vilija Jokubaitis, Eva Havrdová, Dana Horáková, Maria Trojano, Guillermo Izquierdo, Marc Girard, Pierre Duquette, Alexandre Prat, Alessandra Lugaresi, François Grand’Maison, Pierre Grammond, Raymond Hupperts, Celia Oreja‐Guevara, Cavit Boz, Eugenio Pucci, Roberto Bergamaschi, Jeannette Lechner‐Scott, Raed Alroughani, Vincent Van Pesch, Gerardo Iuliano, Ricardo Fernández‐Bolaños, Cristina Ramo‐Tello, Murat Terzi, Mark Slee, Daniele Spitaleri, Freek Verheul, Edgardo Cristiano, José Luis Sánchez-Menoyo, Marcela Fiol, Orla Gray, José Antonio Cabrera-Gómez, Michael Barnett, Helmut Butzkueven,
Prevention of irreversible disability is currently the most important goal of disease modifying therapy for multiple sclerosis. The disability outcomes used in most clinical trials rely on progression of Expanded Disability Status Scale score confirmed over 3 or 6 months. However, sensitivity and stability of this metric has not been extensively evaluated. Using the global MSBase cohort study, we evaluated 48 criteria of disability progression, testing three definitions of baseline disability, two ...
Tópico(s): Viral Infections and Immunology Research
2015 - Oxford University Press | Brain
Athena P. Y. Li, Carolyn A. Cohen, Nancy Leung, Vicky J. Fang, Shivaprakash Gangappa, Suryaprakash Sambhara, Min Z. Levine, A. Danielle Iuliano, Ranawaka A. P. M. Perera, Dkm Ip, Malik Peiris, Mark G. Thompson, Benjamin J. Cowling, Sophie A. Valkenburg,
The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled trial in older adults to compare cellular and antibody responses of S-IIV versus enhanced vaccines (eIIV): MF59-adjuvanted (A-eIIV), high-dose (H-eIIV), and recombinant-hemagglutinin (HA) (R-eIIV). All vaccines induced comparable H3-HA-specific IgG and elevated antibody-dependent cellular cytotoxicity ( ...
Tópico(s): Respiratory viral infections research
2021 - Nature Portfolio | npj Vaccines
Concetta Cuozzo, Antonio Porcellini, Tiziana Angrisano, Annalisa Morano, Bongyong Lee, Alba Di Pardo, Samantha Messina, Rodolfo Iuliano, Alfredo Fusco, Maria Rosaria Santillo, Mark T. Muller, Lorenzo Chiariotti, Max E. Gottesman, Enrico V. Avvedimento,
Tópico(s): DNA Repair Mechanisms
2005 - Public Library of Science | PLoS Genetics
Tomáš Kalinčík, Ali Manouchehrinia, Lukáš Sobíšek, Vilija Jokubaitis, Tim Spelman, Dana Horáková, Eva Havrdová, Maria Trojano, Guillermo Izquierdo, Alessandra Lugaresi, Marc Girard, Alexandre Prat, Pierre Duquette, Pierre Grammond, Patrizia Sola, Raymond Hupperts, François Grand’Maison, Eugenio Pucci, Cavit Boz, Raed Alroughani, Vincent Van Pesch, Jeannette Lechner‐Scott, Murat Terzi, Roberto Bergamaschi, Gerardo Iuliano, Franco Granella, Daniele Spitaleri, Vahid Shaygannejad, Celia Oreja‐Guevara, Mark Slee, Radek Ampapa, Freek Verheul, Pamela McCombe, Javier Olascoaga, Maria Pia Amato, Steve Vucic, Suzanne Hodgkinson, Cristina Ramo‐Tello, Shlomo Flechter, Edgardo Cristiano, Csilla Rózsa, Fraser Moore, José Luis Sánchez-Menoyo, Maria Luisa Saladino, Michael Barnett, Jan Hillert, Helmut Butzkueven,
Timely initiation of effective therapy is crucial for preventing disability in multiple sclerosis; however, treatment response varies greatly among patients. Comprehensive predictive models of individual treatment response are lacking. Our aims were: (i) to develop predictive algorithms for individual treatment response using demographic, clinical and paraclinical predictors in patients with multiple sclerosis; and (ii) to evaluate accuracy, and internal and external validity of these algorithms. ...
Tópico(s): Mycobacterium research and diagnosis
2017 - Oxford University Press | Brain
Jeannette Lechner‐Scott, Benjamin Spencer, Theo de Malmanche, John Attia, Margaret Fitzgerald, Maria Trojano, François Grand’Maison, Jessica Gómez, Guillermo Izquierdo, Pierre Duquette, Marc Girard, Pierre Grammond, Celia Oreja‐Guevara, Raymond Hupperts, Roberto Bergamaschi, Cavit Boz, Giorgio Giuliani, Vincent Van Pesch, Gerardo Iuliano, M. Fiol, Edgardo Cristiano, F. Verheul, Maria Luisa Saladino, Mark Slee, Michael Barnett, Norma Deri, Shlomo Flechter, Norbert Vella, Christopher S. Shaw, Joseph Herbert, Fraser Moore, Tatjana Petkovska‐Boskova, Vilija Jokubaitis, Helmut Butzkueven,
Background: With the advent of MRI scanning, the value of lumbar puncture to assess oligoclonal band (OCB) statusfor the diagnosis of multiple sclerosis (MS) is increasingly uncertain. One major issue is that the reported frequency of cerebrospinal fluid (CSF)-restricted oligoclonal banding for the diagnosis of MS varies considerably in different studies. In addition, the relationship between OCB positivity and disease outcome remains uncertain, as reported studies are generally too small to assess ...
Tópico(s): Systemic Lupus Erythematosus Research
2011 - SAGE Publishing | Multiple Sclerosis Journal
Rachael Wendlandt, Benjamin J. Cowling, Yuyun Chen, Fiona P. Havers, Pat Shifflett, Ying Song, Ran Zhang, Danielle Iuliano, Cuiling Xu, Hongjie Yu, Jun Zhang, Hongjun Zhang, Fenyang Tang, Mark G. Thompson,
This study aims to assess the association between socio-demographic and health characteristics of older adults in Eastern China and knowledge, attitudes, and practices (KAP) about the influenza virus and vaccine.A prospective cohort of 1506 older adults (aged ≥60 years) was enrolled from November to December 2015 in Jiangsu Province. We examined the association between demographics, health and functional status, and cognitive impairment at enrollment with awareness of influenza virus and vaccine and ...
Tópico(s): Vaccine Coverage and Hesitancy
2018 - Elsevier BV | Vaccine
Johannes Lorscheider, Katherine Buzzard, Alexandre Prat, Alessandra Lugaresi, François Grand’Maison, Pierre Grammond, Raymond Hupperts, Raed Alroughani, Patrizia Sola, Cavit Boz, Eugenio Pucci, Jeannette Lechner‐Scott, Vilija Jokubaitis, Roberto Bergamaschi, Celia Oreja‐Guevara, Gerardo Iuliano, Vincent Van Pesch, Franco Granella, Cristina Ramo‐Tello, Daniele Spitaleri, Thor Petersen, Mark Slee, Freek Verheul, Tim Spelman, Radek Ampapa, Maria Pia Amato, Pamela McCombe, Steve Vucic, José Luis Sánchez-Menoyo, Edgardo Cristiano, Michael Barnett, Suzanne Hodgkinson, Javier Olascoaga, María Laura Saladino, Eva Havrdová, Orla Gray, Cameron Shaw, Fraser Moore, Helmut Butzkueven, Tomáš Kalinčík, Dana Horáková, Maria Trojano, Guillermo Izquierdo, Marc Girard, Pierre Duquette,
Tópico(s): Multiple Sclerosis Research Studies
2016 - SAGE Publishing | Multiple Sclerosis Journal
Johannes Lorscheider, Katherine Buzzard, Vilija Jokubaitis, Tim Spelman, Eva Havrdová, Dana Horáková, Maria Trojano, Guillermo Izquierdo, Marc Girard, Pierre Duquette, Alexandre Prat, Alessandra Lugaresi, François Grand’Maison, Pierre Grammond, Raymond Hupperts, Raed Alroughani, Patrizia Sola, Cavit Boz, Eugenio Pucci, Jeannette Lechner‐Scott, Roberto Bergamaschi, Celia Oreja‐Guevara, Gerardo Iuliano, Vincent Van Pesch, Franco Granella, Cristina Ramo‐Tello, Daniele Spitaleri, Thor Petersen, Mark Slee, Freek Verheul, Radek Ampapa, Maria Pia Amato, Pamela McCombe, Steve Vucic, José Luis Sánchez-Menoyo, Edgardo Cristiano, Michael Barnett, Suzanne Hodgkinson, Javier Olascoaga, Maria Luisa Saladino, Orla Gray, Cameron Shaw, Fraser Moore, Helmut Butzkueven, Tomáš Kalinčík,
A number of studies have been conducted with the onset of secondary progressive multiple sclerosis as an inclusion criterion or an outcome of interest. However, a standardized objective definition of secondary progressive multiple sclerosis has been lacking. The aim of this work was to evaluate the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis, to enable comparability of future research studies. Using MSBase, a large, prospectively acquired, global ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2016 - Oxford University Press | Brain
Malia Jones, Karim Khader, Westyn Branch‐Elliman,
... MPH; Alexia Couture, MPH; Carrie Reed, PhD; Danielle Iuliano, PhD; Michael Whitaker, MPH; Hannah Fast, MPH; Aron J. Hall, DVM; Adam MacNeil, PhD; Betsy Cadwell, MSPH; Kristin J. Marks, PhD; Benjamin J. Silk, PhD
Tópico(s): COVID-19 epidemiological studies
2022 - American Medical Association | JAMA Network Open
Molly Steele, Alexia Couture, Carrie Reed, Danielle Iuliano, Michael Whitaker, Hannah E. Fast, Aron J. Hall, Adam MacNeil, Betsy L. Cadwell, Kristin J. Marks, Benjamin J. Silk,
Importance The number of SARS-CoV-2 infections and COVID-19–associated hospitalizations and deaths prevented among vaccinated persons, independent of the effect of reduced transmission, is a key measure of vaccine impact. Objective To estimate the number of SARS-CoV-2 infections and COVID-19–associated hospitalizations and deaths prevented among vaccinated adults in the US. Design, Setting, and Participants In this modeling study, a multiplier model was used to extrapolate the number of SARS-CoV-2 infections ...
Tópico(s): COVID-19 epidemiological studies
2022 - American Medical Association | JAMA Network Open
A. Danielle Iuliano, Yunho Jang, Joyce Jones, C. Todd Davis, David E. Wentworth, Timothy M. Uyeki, Katherine Roguski, Mark G. Thompson, Larisa V. Gubareva, Alicia M. Fry, Erin Burns, Susan C. Trock, Suizan Zhou, Jacqueline M. Katz, Daniel B. Jernigan,
During March 2013-February 24, 2017, annual epidemics of avian influenza A(H7N9) in China resulted in 1,258 avian influenza A(H7N9) virus infections in humans being reported to the World Health Organization (WHO) by the National Health and Family Planning Commission of China and other regional sources (1). During the first four epidemics, 88% of patients developed pneumonia, 68% were admitted to an intensive care unit, and 41% died (2). Candidate vaccine viruses (CVVs) were developed, and vaccine was ...
Tópico(s): Viral Infections and Vectors
2017 - Centers for Disease Control and Prevention | MMWR Morbidity and Mortality Weekly Report
A. Danielle Iuliano, Carrie Reed, Alice Guh, Mitesh Desai, Deborah L. Dee, Preeta K. Kutty, L. Hannah Gould, Mark J. Sotir, Gavin B. Grant, Michael Lynch, Tarissa Mitchell, Jane P. Getchell, Bo Shu, Julie Villanueva, Stephen Lindstrom, Mehran S. Massoudi, Joseph Siebold, Paul Silverman, Gregory L. Armstrong, David L. Swerdlow,
In late April 2009, the first documented 2009 pandemic influenza A (pH1N1) virus infection outbreak in a university setting occurred in Delaware, with large numbers of students presenting with respiratory illness. At the time of this investigation, little was known about the severity of illness, effectiveness of the vaccine, or transmission factors of pH1N1 virus infection. We characterized illness, determined the impact of this outbreak, and examined factors associated with transmission.Health clinic ...
Tópico(s): Smoking Behavior and Cessation
2009 - Oxford University Press | Clinical Infectious Diseases
Ilya Kister, Eric Chamot, Gary Cutter, Tamar Bacon, Vilija Jokubaitis, Stella E. Hughes, Orla Gray, Maria Trojano, Guillermo Izquierdo, François Grand’Maison, Pierre Duquette, Alessandra Lugaresi, Pierre Grammond, Cavit Boz, Raymond Hupperts, Thor Petersen, Giorgio Giuliani, Celia Oreja‐Guevara, Gerardo Iuliano, Jeannette Lechner‐Scott, Roberto Bergamaschi, Maria Edite Rio, Freek Verheul, Marcela Fiol, Vincent Van Pesch, Mark Slee, Helmut Butzkueven, Joseph Herbert,
Abstract Objective To analyze time-trends in age at disability milestones among MS patients who were enrolled into the MSBase International Registry during 1996–2010 period. Methods We used linear regression to describe the relationship between mean age at major EDSS benchmarks and calendar time. We then assessed time-trend in age at initial EDSS rating with a three level linear growth model specifying that patients were nested within each of 20 participating countries. The model estimated the average of ...
Tópico(s): Systemic Lupus Erythematosus Research
2012 - Elsevier BV | Journal of the Neurological Sciences
Alice Guh, Carrie Reed, L. Hannah Gould, Preeta K. Kutty, Danielle Iuliano, Tarissa Mitchell, Deborah L. Dee, Meghna Desai, James R. Siebold, Paul Silverman, M. Massoudi, Michael Lynch, Mark J. Sotir, Gregory L. Armstrong, David L. Swerdlow,
We investigated the first documented university outbreak of the 2009 pandemic influenza A(H1N1) to identify factors associated with disease transmission. An online student survey was administered to assess risk factors for influenza-like illness (ILI), defined as fever with cough or sore throat. Of 6049 survey respondents, 567 (9%) experienced ILI during 27 March to 9 May 2009. Studying with an ill contact (adjusted risk ratios [aRR], 1.29; 95% confidence intervals [CI], 1.01-1.65) and caring for an ...
Tópico(s): Smoking Behavior and Cessation
2010 - Oxford University Press | Clinical Infectious Diseases
Ilya Kister, Tim Spelman, Raed Alroughani, Jeannette Lechner‐Scott, Pierre Duquette, François Grand’Maison, Mark Slee, Alessandra Lugaresi, Michael Barnett, Pierre Grammond, Gerardo Iuliano, Raymond Hupperts, Eugenio Pucci, Maria Trojano, Helmut Butzkueven,
Background Discontinuation of injectable disease-modifying therapy (DMT) for multiple sclerosis (MS) after a long period of relapse freedom is frequently considered, but data on post-cessation disease course are lacking. Objectives (1) To compare time to first relapse and disability progression among 'DMT stoppers' and propensity-score matched 'DMT stayers' in the MSBase Registry; (2) To identify predictors of time to first relapse and disability progression in DMT stoppers. Methods Inclusion criteria for DMT stoppers ...
Tópico(s): Acute Lymphoblastic Leukemia research
2016 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
A. Danielle Iuliano, Joan Brunkard, Tegan K. Boehmer, Elisha Peterson, Stacey Adjei, Alison M. Binder, Stacy Cobb, Philip Graff, Pauline Hidalgo, Mark J. Panaggio, Jeanette J. Rainey, Preetika Rao, Karl Soetebier, Susan Wacaster, ChinEn Ai, Vikas Gupta, Noelle‐Angelique Molinari, Matthew D. Ritchey,
The B.1.1.529 (Omicron) variant of SARS-CoV-2, the virus that causes COVID-19, was first clinically identified in the United States on December 1, 2021, and spread rapidly. By late December, it became the predominant strain, and by January 15, 2022, it represented 99.5% of sequenced specimens in the United States* (1). The Omicron variant has been shown to be more transmissible and less virulent than previously circulating variants (2,3). To better understand the severity of disease and health care ...
Tópico(s): COVID-19 Clinical Research Studies
2022 - Centers for Disease Control and Prevention | MMWR Morbidity and Mortality Weekly Report