Giles Smith, Andrew Robson, Lucy Alexander, Gabriele Marcotti, Professor Donald Read, Drewent May, Robert Cole, Shaun Woodward Licensing Minister, Michael Kapoor, DJM, Tom Rowland, Frances Gibb Legal Editor, David Aaronovitch, David Outram, Theodore Dalrymple, Michael Owen, Dr David Bebbington, Richard Ford and Frances Gibb, Michael Evans Defence Editor, Philip Howard, Hannah Betts, David Pannick, Christine Seib, David Chater, David Lammy Minister for Culture, James Bone, James Ducker, Penny Wark, Bronwen Maddox Foreign Editor, Richard Irving, Gabrielle Starkey, Sam Marlowe, Steve Ryder, Bruce Stockler, Joe Joseph, John Crompton, Rajeev Syal and Andrew Pierce, John Coughlan, Robin Bather, Kathryn Ruemmler, Pat Gibson, Jane MacArtney, Gabby Logan, Michael Heaney, Anthony Browne, Jack Malvern, John Radford, Dan Sabbagh Media Editor, Gary Jacob, Tim Reid, Dan Sabbagh, Jane Clarke, Jonathan Gornall, Libby Purves, Richard Ford Home Correspondent, James A. Grant, David Hands, Charles Bremner, Jonathan Tardif, Liz Chong, Valerie Elliott and Lewis Smith, Hugo Rifkind, Angela Jameson, Alan Davies, Russell Kempson, Edward Fennell, Gary Duncan Economics Editor, Gerard Baker, Jeffrey Jowell, Professor, Barbara Russell, David Evans, Philip Webster and Peter Riddell, Ann Treneman, Gabriel Rozenberg Economic Reporter, Rob Wright, James Couser, Raymond Keene, Matt Dickinson, Matt Hughes, Albie Sachs, Jane MacArtney and Gary Duncan, Chris Campling, Patrick Hosking, Peter Riddell and Philip Webster, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, Mark Irving, David Mattin, Gabriel Rozenberg Economics Reporter, Nick Hasell, Dominic Kennedy and Andrew Pierce, David Hands Rugby Correspondent, Lewis Smith and Valerie Elliott, Julian Muscat, Paul Simons, Tony Cascarino, Adam Fresco, Tom Dart, Joanna Pitman, John Cooper, David Eyre, Jane Shilling, Linda Gray, Dr N. P. Hudd, Ashling O'connor, Ella Stimson, George Caulkin, Kalyani Menon, Russell Jenkins, Neil Fisher, Michael Burton, Peter Riddell, Tom Bawden and Neelam Verjee, Carly Chynoweth, Tom Hennigan, David Charter Chief Political Correspondent, Jacqui Goddard, David Sinclair, Alan B. Shrank, Martin Waller, Chris Ayres, Gary Duncan and Gabriel Rozenberg, Dominic Grieve, Benedict Nightingale, Oliver Kamm, Louise Cohen, Stephen Cragg, Stephen Dalton, Philip Freeman, Ben Hoyle, Richard Morrison, Frances Gibb, Gill Lane, Owen Slot, Nicola Copping, Ross Anderson, Sam Lister Health Correspondent, Kaveh Sohlekol,
... Poulter's Style Counsel Fearless Eboue Making a Mark Tom Dart on the young ... the hardest job Van Bommel is Set on History Matt Hughes says midfield ...
2006 - Gale Group | TDA
Merlijn van Hulst, Tamara Metze, Art Dewulf, Jasper de Vries, Séverine van Bommel, Mark van Ostaijen,
Three decades after the argumentative turn in policy analysis and planning, interpretive approaches have become part of mainstream policy analysis. Increasingly, researchers work within these traditions. Researchers new to these approaches might struggle to make conceptual and methodological choices. We therefore compare three prominent interpretive approaches: discourse analysis, framing analysis and narrative analysis. Discourse analysis is the study of hegemonic, dominant and recessive discursive ...
Tópico(s): Evaluation and Performance Assessment
2024 - Taylor & Francis | Critical Policy Studies
Laskhmi Niwas Mittal, Waldemar Januszczak, Lisa Solley, V S, Lord Glenconner, Amanda Ursell, Emma Moore, Jonathan Miller, Jerrey Clarkson, Alastair McCall, Julian Chichester, Leslie Fraser-Mitchell, Martin James, R A S Crowe, Rosie Millard, Jovial airman, Hugh Canning, Phil Walsh, Peter Carbery, Andrew Oswald, Fergal Cox, Tim Lott, Billy Tidy, Paul Bailey, Rubbie Hudson, Caroline Scott, Shelley Von Strunckel, Julian Corlett, Christopher Morgan, Philip Treacy, Mark Hardshorne, Brian Jackman, Cathy Galvin, Danny O'Brien, Graham Asher, Michael Wright, Inacio Riberio, Kate Rew, Irwin Steizer, Nick Rennison, Lois Rogers Medical Correspondent, Shirley Thompson, Charles Crichton, John Elliott, Maurice Chittenden, Ronald White, Richard Brooks Arts Editor, John Humphruys, Jonathan Powell, Godfrey Smith, Robert Winnett Consumer Affairs Correspondent, Tim Martin, Matthew Campbell, Lord May, Feckenham, Nick Fielding, David Tompkins, Sophie Pither, John Spurling, Lord Levy, Graham Norwood, David Budworth, Mrs Mills, Anna King, Craig Buglass, Dan Pearson, Barry Newcombe, Farewell, M Dodds, Simon Molden, Jonathan Northcroft, Nicholas Owen, Lucy Hughes-Hallet, Dr Michael Apple, Emine Saner, Sir Peter Mason, Richard Green, E P, Andrew Sullivan, Clive Davis, Nazreen Mills, Liz Hodgkinson, Paul Denovan, Michael Holden, Robert Temple, Geraldine Hackett, Cally Law, Dr Rita Henry, Alasdair Reid, Philip Mansel, Keith Wheatle, John Settle Chief Inspector, Graham Duffill, Victoria Segal, Edward Porter, Michael Lane, Rod Eddington, David Eimer, Adam Nathan, Hugh McIlvanney, Steve Boyd, Peter Dabinett, Tony Coleman, Richard Brooks, David Leppard, Simon Contable, Kewin P O'Brien, Lois Rogers, J Reddell, Lord Hollick, David Cracknell, Diana Wright, Andy Knott, Barry Flatman, Rosie Thomas, Keith Wheatley, David Walsh, Dominic O'Cornnell, Stephen Armstrong, Richard Woods, Mel Bradman, Michael Burrows, Ray Hutton, Martin Ivens, John Biggins, Ian Fulton, Hilary Lowe, Rupert Stelner, A A Gill, Sasha Slater, Brian Glanville, Jim Murro, Jonathan Carr-Brown, David Sunner Smith, Nigel Powell, John Cornwell, Jonathan Futrell, Hugh Pearman, Kirstia Hamilton, Tom Deveson, Van Gogh, Peter Hennessy, Conal Gregory, Marcia Roberts, Richard Lewis, John Dugdale, Hitler Secretary, Barbara Hall, Nicholas Rufford, Rob Hughes, John Peter, Neil Wormalo, Jane Mulkerrins, J D, Matt Wolf, David Smith, Rory Godson, David Cracknell Political Editor, Guy Dennis, Sue Leonard, Patricia Nichol, Wendy Holden, Lawrence Dallaglio, Edward Luttwak, Ken Paul, Philip Kingsley, Metiel McCogey, Robert Peston, David Badworth, Patricia Nicol, Rowan Atkinson, John O'Donnell, Nick Gardner, James B Sherwood, Maggie Gee, Gareth Huw Daviies, Harvey Cole, Alex Clark, Dominic Utto, Mark Edwards, Kirstie Hamilton, Michael Dibdin, Susan Clark, Louise Gannon, Clover Hughes, Sean Newsom, Raymond Keene, Stephen Jones, Tim Moorey, R W Johnson, Roland White, Mark Franchetti, Caroline Brien, Frank Warhol, Michael Sheridan, Sandra Cole, Barry Collins, John Waples, Ros Dodd, Natalle Graham, Tom Robbins, Stephen Pettitt, Maria McErlane, Jonathan Calvert, James Conroy, Tom Walker Diplomatic Correspondent, Katharine Hamnett, Mark Hodson, Andrew Frankel, Chris Fisher, Joe Lovejoy, Kevin Maguire, Penny Perrick, Simon Crerar, Stephen Alexander, Tim Johnston, Chris Tenove, David Hawson, Simon Howard, Dominic Rushe, Karen Robinson, J K Rowling, Clare Beckell, James Clark, Fame Fatale, Pam Barrett, St Saviour's Dock, Dr Penelope Elphinstone, Kathryn Cooper, Matt Foster, P D, David Schwartz, Damian Green, Tony Allen-Mills, Simon Forester, Simon Wilde, Robert Sandall, Robert Winnett, Irwin Stelzer, Peter Wilson, David Dougill, Faber, Lois Rogens Medical correspondent, Ken Ruddiman, Jonathon Carr-Brown, Margarette Driscoll, Jeremy Clarkson, David Cairns, Frank Fitzgibhon, Louise Taylor, Frank Issck, Paul Ogden, Liz Edwards, Sam Murphy, Jullan Corlett, Kristle Hamilton, Giles Milton, Alexandra Fuller, Beverley D'Silva, Roger Eglin, Oily Duke, Joe Horne, Lucinda Kemeny, Jasper Gerard, Paul Driver, Nick Newman, Ian Hawkey, Uzi Mahnalmi, Paul Durman, Derren Gilhooley, Mrs Julla Kinsey, Ruth O'Callaghan, David Beckham, Victoria O'Brien, Sue Reid, Douglas Alexander, Cosmo Landesman, Dominic O'Connell, M J, John Adams, Christopher Goodwin, David Price, Jack Russell, Estelle Morris, Jonathan Clayton, Judith O'Reilly, Jonathan Leake, John Harlow, Albert Herring, Bordex Wine Racks, Claudia Croft, Lewis Stuart, Jonathan Leake Science Editor, Bob Ayling, Sally Kinnes, David Wickers, Minette Marrin, Rupert Steiner, Gauguin, John Alzlewood, Joanna Simon, Matthew Goodman, India Knight, Steve Grant, Kingston Smith, Adrian Somerfield, Rosie Waterhouse, Boris Schapiro, Nicola Gill,
... Prepair for the Big World Cup Pick-Off Van Bommel in a hurry The Dutch star can bring ...
2002 - Gale Group | Sunday Times HA GDA
J. A. Kanters, A. Schouten, Mark van Bommel,
C12H24O11.H2O, Mr = 362.4, orthorhombic, P2(1)2(1)2(1), a = 7.808 (2), b = 12.685 (2), c = 15.931 (3) A, V = 1577.9 (6) A3, Z = 4, Dx = 1.525 Mg m-3, lambda(Mo K alpha) = 0.71073 A, mu = 0.13 mm-1, F(000) = 776, T = 295 K, R = 0.031 for 1781 unique reflections with I greater than 2.5 omega (I). The galactopyranosyl ring has the 4C1 chair conformation and the conformation of the bent glucitol C-atom chain is MAA. The torsion angles characterizing the conformation of the glycosidic linkage are -86.3 (2) degrees [O(5)--C(1)--O(1)-- ...
Tópico(s): Glycosylation and Glycoproteins Research
1990 - Wiley | Acta Crystallographica Section C Crystal Structure Communications
Andrew Robson, Katharine Whitehorn, Malcolm Turner, Steward Tendler and Dominique Searle, Chris MacLean, Carol Lewis, Andrew Billen, Robert Cole, Stewart Tendler and Sam Coates, Andrew Pierce, DJM, Jacques Baudot, Adam Sherwin Media Reporter, Tom Dyckhoff, Adam Fresco and Michael Evans, Robert Thicknesse, Linda Tsang, Steven Ramsey, Michal Kaminski, David Rose, Ivo Tennant, Michael Evans Defence Editor, Francis Pott, Alex Wade, James Bone, Penny Wark, Harry Van Bommel, Peter Riddell and Martin Booth, Bronwen Maddox Foreign Editor, Elizabeth Judge, John Goodbody and Alan Lee, Richard Irving, Gabrielle Starkey, James Hider, Geoff Brown, B. Merriott, Joe Joseph, David McVay, Mike Curry, Bill Braithwaite, QC, Dominic Walsh, Steve Bird, Robert Smart, David and Coral Slade, Hugh Tunstall-Pedoe, Andrew Oswald, Jill Dupleix, Tim Reid, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Dan Sabbagh, Libby Purves, Jane Clarke, Alan Hamilton, Esko Seppaennen, Stephen Farrell, Anthony Browne Brussels Correspondent, Anatole Kaletsky, David Pearce, Ian Baildon-Smith, Roland Watson, Richard Lloyd Parry, Ian MacKinnon, Ron Lewis, Stefanie Marsh, Matt Dickinson Chief Football Correspondent, David Pannick, QC, David Charter, Rev. Canon Prof. Martyn William, Sue Hobson, Caroline Merrell Banking Correspondent, Matthew McGregor Director, Robin Wendt, Russell Kempson, Daniel McGrory, Edward Fennell, Norman Giller, Raj Kothari, John Woodcock, Gabriel Rozenberg, Gary Duncan and Sarah Butler, David Lister, John Westerby, Tom Baldwin, Jill Sherman Whitehall Editor, Sam Coates, Eve Thomas, Ann Treneman, Alan Lee Racing Journalist, Simon de Bruxelles, Rob Wright, Geoffrey Dean, James March, Mark Hunter, Caroline Lucas, Neil Harman Tennis Correspondent, David Powell Athletics Correspondent, Martin Samuel, Raymond Keene, Daniel Allen, Matthew Pryor, Steve Boggan, M. F. Holland, Simon Milton, James Michael, Sean O'Neill, Caroline Merrell, Chris Campling, Michael H. Pester, Richard Owen, Matt Dickinson and George Caulkin, Christopher Martin-Jenkins Chief Cricket Correspondent, Jon Robins, Erica Wagner, Alex Hickman (Chief Executive, Peter Dixon, Nick Hasell, Stewart Tendler, Chris Wall, David Hands Rugby Correspondent, Paul Simons, Roland White, John Allison, Steve Jelbert, Nick Szczepanik, John Goodbody, John Cooper, Philip Webster Political Editor, Anjana Ahuja, Lars Wohlin, Bruce Anderson, Russell Jenkins, Caitlin Moran, Alan Lee, Neil Murray, Penny Archer, Peter Riddell, Allen Robertson, DR Thomas Stuttaford, Catherine Philp, Martin Waller, Chris Ayres, Lisa Verrico, David Pearce (National Chairman, Sarah Butler, Antony Hook, Tony Moore, Stan Nicholls, Miriam Raphael, Stephen Cragg, Stephen Dalton, Dr Thomas Stuttaford, David Powell, Thomas Rupp Director, Randy Cohen, Sir David Calvert-Smith, Loraine Martins, Anthony Howard, Jenny Davey, Edward Gorman Sailing Correspondent, Shamim Ahmed, Ron Marchant Chief Executive, Peter Klinger, Oliver Kay and Nick Szczepanik, Patience Wheatcroft, Christopher Irvine,
The Times Labour feud fails to move voters High street woe Abbas invitation Public Agenda Best of enemies Sceptics united Phone plan slated Index Monuments ...
2005 - Gale Group | TDA
Ann Witvrouw, L. Haspeslagh, Olalla Varela Pedreira, Jeroen De Coster, Ingrid De Wolf, H.A.C. Tilmans, Twan Bearda, Bart Schlatmann, Mark van Bommel, Marie-Christine de Nooijer, P.H.C. Magnée, E. J. Lous, Marco Hagting, John Lauria, Roel Vanneer, Bert van Drieenhuizen,
In this paper, we report on the design, fabrication, packaging, and testing of very reliable CMOS-integrated 10-cm 2 11-megapixel SiGe-based micromirror arrays on top of planarized six-level metal 0.18-¿m CMOS wafers. The array, which is to be used as a spatial light modulator (SLM) for optical maskless lithography, consists of 8 ¿m × 8 ¿m pixels, which can be individually addressed by an analog voltage to enable accurate tilt angle modulation. Due to very stringent requirements on mounted-die flatness (< ...
Tópico(s): Thin-Film Transistor Technologies
2010 - Institute of Electrical and Electronics Engineers | Journal of Microelectromechanical Systems
Marcel H.A. Muskiet, Lennart Tonneijck, Erik J.M. van Bommel, Mark M. Smits, Daniël H. van Raalte,
In their research digest, Sattar and Preiss1Sattar N Preiss D Research digest.Lancet Diabetes Endocrinol. 2016; 4: 651Summary Full Text Full Text PDF PubMed Scopus (2) Google Scholar highlight the beneficial renal outcomes in LEADER2Marso SP Daniels GH Brown-Frandsen K et al.Liraglutide and cardiovascular outcomes in type 2 diabetes.N Engl J Med. 2016; 375: 311-322Crossref PubMed Scopus (4230) Google Scholar and EMPA-REG OUTCOME,3Wanner C Inzucchi SE Lachin JM et al.for the EMPA-REG OUTCOME InvestigatorsEmpagliflozin ...
Tópico(s): Pancreatic function and diabetes
2016 - Elsevier BV | The Lancet Diabetes & Endocrinology
Eric F.H. van Bommel, Mark A. van der Zijden, P. J. H. Smak Gregoor, Tadek R. Hendriksz, Shiuw H. Ho-Han, Pieter J. Westenend,
Erdheim–Chester Disease (ECD) is a rare, non-Langerhans histiocytosis, characterized by the accumulation of foamy macrophages, chronic inflammation, fibrosis and organ failure [1,2]. Interferon alf...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2019 - Taylor & Francis | Acta Oncologica
Erik J.M. van Bommel, Mark M. Smits, Danique Ruiter, Marcel H.A. Muskiet, Mark H.H. Kramer, Max Nieuwdorp, Daan J. Touw, Hiddo J.L. Heerspink, Jaap A. Joles, Daniël H. van Raalte,
There is a bidirectional relationship between cardiovascular and renal disease. The drug-class of SGLT2 inhibitors improves outcomes at both ends of this so called cardiorenal axis. We assessed the effects of SGLT2 inhibition and sulfonylurea treatment on systemic hemodynamic function and investigated whether SGLT2 inhibitor-induced changes in systemic hemodynamics correlate with changes in renal hemodynamics.Forty-four people with type 2 diabetes were randomized to 12 weeks of dapagliflozin 10 ...
Tópico(s): Pancreatic function and diabetes
2020 - Lippincott Williams & Wilkins | Journal of Hypertension
Marcel H.A. Muskiet, Daniël H. van Raalte, Erik J.M. van Bommel, Mark M. Smits, Lennart Tonneijck,
The EMPA-REG OUTCOME study,1 in which the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin showed impressive benefits on cardiovascular mortality, all-cause mortality, and hospital admission for heart failure, could change type 2 diabetes management in years to come.2 The remarkable effect size and rapid onset (<3 months) were unexpected, which suggests a need for an improved understanding of the mechanisms involved to fully exploit the clinical benefits of this antihyperglycaemic drug.
Tópico(s): Pancreatic function and diabetes
2015 - Elsevier BV | The Lancet Diabetes & Endocrinology
Erik J.M. van Bommel, Hilde Herrema, Mark Davids, Mark H.H. Kramer, Max Nieuwdorp, Daniël H. van Raalte,
Patients with type 2 diabetes (T2D) are usually treated with (combinations of) glucose-lowering medication. The effects of these drugs can be influenced by intestinal microbiota and vice versa, as these drugs can also influence microbiome composition. However, as there is currently little clinical insight into this bug–drug interaction, our study aimed to evaluate the effects of 12-week treatment with the SGLT2 inhibitor dapagliflozin and sulphonylurea gliclazide on gut microbiome composition in T2D ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2019 - Elsevier BV | Diabetes & Metabolism
Jan A. Kanter, Arie Schouten, Mark van Bommel,
Crystallization of lactitol from aqueous ethanol readily yields crystals of the monohydrate, the structure of which has recently been reported. Slow evaporation of very concentrated aqueous syrups results in the crystalline dihydrate. The space group is P43212 with a = 8.762(2), c = 45.508(8) Å, V = 3493.8(13) Å3, Z = 8, Dc = 1.446 g cm−3, R = 0.037 for 2017 unique observed reflections and 310 variables. The galactopyranosyl ring has the 4C1 chair conformation and the carbon chain of the glucitol fragment has ...
Tópico(s): Microbial Metabolites in Food Biotechnology
1990 - Elsevier BV | Journal of Molecular Structure
Peter E. van Bommel, Yuan He, Ilona Schepel, Mark A.J.M. Hendriks, Valerie R. Wiersma, Robert J. van Ginkel, Tom van Meerten, Emanuele Ammatuna, Gerwin Huls, Douwe F. Samplonius, Wijnand Helfrich, Edwin Bremer,
Here, we report on a novel bispecific antibody-derivative, designated RTX-CD47, with unique capacity for CD20-directed inhibition of CD47-SIRPα "don't eat me" signaling. RTX-CD47 comprises a CD20-targeting scFv antibody fragment derived from rituximab fused in tandem to a CD47-blocking scFv. Single agent treatment with RTX-CD47 triggered significant phagocytic removal of CD20pos/CD47pos malignant B-cells, but not of CD20neg/CD47pos cells, and required no pro-phagocytic FcR-mediated signaling. Importantly, ...
Tópico(s): Immune Cell Function and Interaction
2017 - Landes Bioscience | OncoImmunology
Daniel Rob, R. Špunda, Jaroslav Lindner, Jana Šmalcová, Ondřej Šmíd, Tomáš Kovárník, Aleš Linhart, J. Bìlohlávek, Marinella Marinoni, Giovanni Cianchi, Sandra Trapani, Maria Luisa Migliaccio, L. Gucci, Manuela Bonizzoli, Antonella Cramaro, Mario Cozzolino, S. Valente, A Peris, Edgars Grins, Eric J. Kort, Matthew Weiland, N. Manandhar Shresta, Patricia M. Davidson, Lars Algotsson, Stephen Fitch, G. Marco, Jamie Sturgill, S. Lee, Michael G. Dickinson, Theodore Boeve, A. Khaghani, P. Wilton, Stefan Jovinge, A. N. Ahmad, Robert Loveridge, Savvas Vlachos, S. Patel, Elton Gelandt, L. Morgan, Shamaila Butt, M. Whitehorne, Vivek Kakar, C. Park, Michelle Hayes, Chris Willars, Tom Hurst, Tony Best, André Vercueil, G. Auzinger, B. Adibelli, N. Akovali, Adnan Torgay, Pınar Zeyneloğlu, A. Pirat, Zeynep Kayhan, Simon Schmidbauer, Johan Herlitz, Thomas Karlsson, Hans Friberg, Rihard Knafelj, Peter Radšel, Frédéric Duprez, T. Bonus, G. Cuvelier, S. Mashayekhi, M. Mąka, S. Ollieuz, Grégory Reychler, Reza Mosaddegh, Saeed Abbasi, Saeed Talaee, Viviane Zotzmann, Dawid L. Staudacher, Tobias Wengenmayer, D. Dürschmied, Christian Bode, Annika Nelskylä, Jouni Nurmi, Milla Jousi, Alexey Schramko, Elina E. Mervaala, Giuseppe Ristagno, Markus B. Skrifvars, Gamze Özsoy, Tanıl Kendirli, Ebru Azapağası, Oktay Perk, Ulker Gadirova, Evren Özçınar, Mehmet Çakıcı, Caner Baran, Serkan Durdu, Adnan Uysalel, Murat Doğan, Mehmet Gökhan Ramoğlu, Tayfun Uçar, Ercan Tutar, Semra Atalay, Rüçhan Akar, Marlijn J. A. Kamps, G. Leeuwerink, Jeannette Hofmeijer, Oscar Hoiting, J van der Hoeven, Cornelia Hoedemaekers, Aidos Konkayev, В. Н. Куклин, T. Kondratyev, M. E. Konkayeva, N. Akhatov, Mikhail A. Sovershaev, T. Tveita, Vegard Dahl, Lauri Wihersaari, Markus B. Skrifvars, Stepani Bendel, Kirsi-Majia Kaukonen, Jukka Vaahersalo, Jarkko Romppanen, Ville Pettilä, M Reinikainen, Anna Lybeck, Tobias Cronberg, Niklas Nielsen, Hans Friberg, Martin Rauber, Klemen Steblovnik, Anamarija Jazbec, M Noc, Prathima Kalasbail, F Garrett, Erik Kulstad, David Bergstrom, Helén Olsson, Simon Schmidbauer, Hans Friberg, Irina A. Mandel, S. Mikheev, Y. Podoxenov, I. V. Suhodolo, A Podoxenov, J. Svirko, А. С. Семенцов, Л. Н. Маслов, V. Shipulin, L. V. Vammen, S. R. Rahbek, N. S. Secher, Johan Povlsen, Niels Jessen, Bo Løfgren, Asger Granfeldt, Anne V. Grossestreuer, Sarah M. Perman, Priya Patel, Sarah Ganley, J Portmann, M.N. Cocchi, Michael W. Donnino, Yasser Nassar, Seham Fathy, Ayman Gaber, S Mokhtar, Yifeng Chia, R. Lewis-Cuthbertson, Khawaja Mustafa, Ahmed Sabra, Alice C. Evans, Paul Bennett, Ward Eertmans, Cornelia Genbrugge, W. Boer, Jo Dens, C. De Deyne, Frank Jans, Agnieszka Skorko, Matthew Thomas, Maria Chiara Casadio, Anna Coppo, Alessia Vargiolu, J.L. Catoya Villa, M. Rota, Leonello Avalli, Giuseppe Citerio, J. B. Moon, J. H. Cho, C. W. Park, T. G. Ohk, M. C. Shin, Mi Hwa Won, Panagiotis Papamichalis, V. Zisopoulou, Efthimios Dardiotis, Spyridon Karagiannis, D. Papadopoulos, Tilemachos Zafeiridis, Dimitris Babalis, Apostolia-Lemonia Skoura, Ioannis Staikos, A. Komnos, S. Silva Passos, Fernando Maeda, L. Silva Souza, Arnaldo Filho, T. Araújo Guerra Granjeia, Marcelo Schweller, Daniel Franci, Carvalho Filho, Thiago Martins Santos, Pinto Azevedo, R. Wall, Ingeborg Welters, Phantakan Tansuwannarat, Pitsucha Sanguanwit, Thomas Länger, Marco Carbonara, Alessio Caccioppola, Chiara Ferraris Fusarini, Eleonora Carlesso, E. Paradiso, M. Battistini, Emanuele Cattaneo, Francesco Zadek, Rita Maiavacca, Nino Stocchetti, Antonio Pesenti, Alberto San Francisco Ramos, F. Acharta, João Toledo, M. Perezlindo, Luciano Lovesio, A M Dogliotti, Carlos Lovesio, Nicolas F. Schroten, Barbara van Veen, Martine C. de Vries, Joshua M. Veenstra, Yasser B. Abulhasan, Susan P. Rachel, Marc-Olivier Châtillon-Angle, Najayeb Alabdulraheem, Ian Schiller, Nandini Dendukuri, Mark Angle, Charles Frenette, Shouri Lahiri, Konrad Schlick, Stephan A. Mayer, Patrick D. Lyden, M Akatsuka, Johji Arakawa, Michiaki Yamakage, J. A. Rubio, Jose Alfonso Rubio Mateo-Sidrón, Rafael Sierra, Mikel Celaya, Luis Benitez, S. Alvarez-Ossorio, J. A. Rubio, Jose Alfonso Rubio Mateo-Sidrón, Rafael Sierra, Analía Fernández, Óscar González, Henrik Engquist, Elham Rostami, Per Enblad, João Toledo, Alberto San Francisco Ramos, F. Acharta, Luigi Canullo, José Nallino, A M Dogliotti, Carlos Lovesio, Marc M. Perreault, J. Talic, Anne-Julie Frenette, Lisa Burry, Françis Bernard, D. R. Williamson, Dalia Adukauskienė, Justina Čyžiūtė, Agnė Adukauskaitė, Lina Malcienė, Livio De Luca, Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Marius Păpurică, Mirela Sărăndan, Carmen Alina Cradigati, Sonia Elena Popovici, Corina Vernic, Dorel Săndesc, В Е Аваков, I. Shakhova, H. Trimmel, Marek Majdán,
Sevoflurane sample data in a standard single patient ICU room, VieCuri Medical Centre. Physical data of the ICU room: 52 m3, air refreshing rate minimum 6/hr
BioMed Central
Erik J.M. van Bommel, Marcel H.A. Muskiet, Lennart Tonneijck, Mark H.H. Kramer, Max Nieuwdorp, Daniël H. van Raalte,
Diabetic kidney disease not only has become the leading cause for ESRD worldwide but also, highly contributes to increased cardiovascular morbidity and mortality in type 2 diabetes. Despite increased efforts to optimize renal and cardiovascular risk factors, like hyperglycemia, hypertension, obesity, and dyslipidemia, they are often insufficiently controlled in clinical practice. Although current drug interventions mostly target a single risk factor, more substantial improvements of renal and cardiovascular ...
Tópico(s): Pancreatic function and diabetes
2017 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
Lennart Tonneijck, Marcel H.A. Muskiet, Mark M. Smits, Erik J.M. van Bommel, Hiddo J.L. Heerspink, Daniël H. van Raalte, Jaap A. Joles,
An absolute, supraphysiologic elevation in GFR is observed early in the natural history in 10%–67% and 6%–73% of patients with type 1 and type 2 diabetes, respectively. Moreover, at the single-nephron level, diabetes-related renal hemodynamic alterations—as an adaptation to reduction in functional nephron mass and/or in response to prevailing metabolic and (neuro)hormonal stimuli—increase glomerular hydraulic pressure and transcapillary convective flux of ultrafiltrate and macromolecules. This phenomenon, ...
Tópico(s): Parathyroid Disorders and Treatments
2017 - American Society of Nephrology | Journal of the American Society of Nephrology
Mark J. Boogers, Ji Chen, Rutger J. van Bommel, C. Jan Willem Borleffs, Petra Dibbets‐Schneider, Bernies van der Hiel, Imad Al Younis, Martin J. Schalij, Ernst E. van der Wall, Ernest Garcia, Jeroen J. Bax,
The aim of the current study was to evaluate the relationship between the site of latest mechanical activation as assessed with gated myocardial perfusion SPECT (GMPS), left ventricular (LV) lead position and response to cardiac resynchronization therapy (CRT).The patient population consisted of consecutive patients with advanced heart failure in whom CRT was currently indicated. Before implantation, 2-D echocardiography and GMPS were performed. The echocardiography was performed to assess LV end-systolic ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2010 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
Eric F.H. van Bommel, Mark de Mol, Anton W. Langerak, Pieter J. Westenend,
We present a case of atypical idiopathic retroperitoneal fibrosis (iRPF) presenting as a large pelvic tumor, for which it proved difficult to exclude T‐cell malignant lymphoma. Histopathological examination of biopsy material showed collagenous tissue and fat with an exuberant and predominant T‐cell infiltrate, largely consisting of CD4 + cells expressing the IL‐2 receptor‐α chain (CD25). Focal plasma cells were negative for the immunoglobulin G4 (IgG4) isotype. T‐cell receptor gene rearrangement (TRGR) ...
Tópico(s): Gastrointestinal disorders and treatments
2011 - Wiley | Pathology International
Erik J.M. van Bommel, Marcel H.A. Muskiet, Michaël J.B. van Baar, Lennart Tonneijck, Mark M. Smits, Anna L. Emanuel, Andrea Božović, A.H. Jan Danser, Frank Geurts, Ewout J. Hoorn, Daan J. Touw, Emil List Larsen, Henrik E. Poulsen, Mark H.H. Kramer, Max Nieuwdorp, Jaap A. Joles, Daniël H. van Raalte,
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve hard renal outcomes in type 2 diabetes. This is possibly explained by the fact that SGLT2i normalize the measured glomerular filtration rate (mGFR) by increasing renal vascular resistance, as was shown in young people with type 1 diabetes and glomerular hyperfiltration. Therefore, we compared the renal hemodynamic effects of dapagliflozin with gliclazide in type 2 diabetes. The mGFR and effective renal plasma flow were assessed using inulin ...
Tópico(s): Renal Diseases and Glomerulopathies
2019 - Elsevier BV | Kidney International
Mark J. Boogers, Ji Chen, Caroline E. Veltman, Rutger J. van Bommel, Eline A.Q. Mooyaart, Imad Al Younis, Bernies van der Hiel, Petra Dibbets‐Schneider, Ernst E. van der Wall, Martin J. Schalij, Ernest Garcia, Jeroen J. Bax, Victoria Delgado,
The aim of the current study was to evaluate the feasibility of phase analysis on gated myocardial perfusion SPECT (GMPS) for the assessment of left ventricular (LV) diastolic dyssynchrony in a head-to-head comparison with tissue Doppler imaging (TDI).The population consisted of patients with end-stage heart failure of New York Heart Association functional class III or IV with a reduced LV ejection fraction of ≤ 35%. LV diastolic dyssynchrony was calculated using TDI as the maximal time delay between ...
Tópico(s): Cardiac Imaging and Diagnostics
2011 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
Erik J.M. van Bommel, Danique Ruiter, Marcel H.A. Muskiet, Michaël J.B. van Baar, Mark H.H. Kramer, Max Nieuwdorp, Jaap A. Joles, Petter Bjornstad, Daniël H. van Raalte,
Impaired insulin sensitivity is associated with hyperfiltration (i.e., elevated glomerular filtration rate [GFR]) in adolescents with type 2 diabetes (T2D) and adults with prediabetes. Yet, these relationships are based on studies that relied on estimated GFR (eGFR), estimates of insulin sensitivity, or both. We aimed to verify the relationship between insulin sensitivity and renal hemodynamic function by gold standard methods in adults with T2D.Insulin sensitivity was assessed by hyperinsulinemic-euglycemic ...
Tópico(s): Diabetes Management and Research
2019 - American Diabetes Association | Diabetes Care
Eric F.H. van Bommel, Mark A. van der Zijden, Otto E. H. Elgersma, Tadek H. Hendriksz,
van Bommel, Eric F. H. MD, PhD; van der Zijden, Mark A. MD; Elgersma, Otto E. H. MD, PhD; Hendriksz, Tadek H. MD Author Information
Tópico(s): Muscle and Compartmental Disorders
2019 - Lippincott Williams & Wilkins | JCR Journal of Clinical Rheumatology
Danii L. S. Suijk, Michaël J.B. van Baar, Erik J.M. van Bommel, Zainab Iqbal, Merle M. Krebber, Volker Vallon, Daan J. Touw, Ewout J. Hoorn, Max Nieuwdorp, Mark M.H. Kramer, Jaap A. Joles, Petter Bjornstad, Daniël H. van Raalte,
Background and objectives Sodium-glucose transporter 2 (SGLT2) inhibitor–induced uric acid lowering may contribute to kidney-protective effects of the drug class in people with type 2 diabetes. This study investigates mechanisms of plasma uric acid lowering by SGLT2 inhibitors in people with type 2 diabetes with a focus on urate transporter 1. Design, setting, participants, & measurements We conducted an analysis of two randomized clinical trials. First, in the Renoprotective Effects of Dapagliflozin ...
Tópico(s): Diabetes Treatment and Management
2022 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
Linda van Bommel, Christopher N. Johnson,
The behavioural mechanisms by which livestock guardian dogs (LGDs) protect livestock from wild predators are not yet fully understood. LGD urine could play a part, as scent-marking the boundaries of a territory could signal occupation of the area to predators. Past selection for dogs that were most effective in deterring predators could have resulted in LGDs that produce urine with predator-deterrent properties. In this research, 28 captive dingoes (14 male and 14 female) were tested for their response ...
Tópico(s): Animal Behavior and Welfare Studies
2017 - CSIRO Publishing | Australian Mammalogy
Mark J. Boogers, C. Jan Willem Borleffs, Maureen M. Henneman, Rutger J. van Bommel, Jan van Ramshorst, Eric Boersma, Petra Dibbets‐Schneider, Marcel P. M. Stokkel, Ernst E. van der Wall, Martin J. Schalij, Jeroen J. Bax,
The purpose of this study was to evaluate whether 123-iodine metaiodobenzylguanidine (123-I MIBG) imaging predicts ventricular arrhythmias causing appropriate implantable cardioverter-defibrillator (ICD) therapy (primary end point) and the composite of appropriate ICD therapy or cardiac death (secondary end point). Although cardiac sympathetic denervation is associated with ventricular arrhythmias, limited data are available on the predictive value of sympathetic nerve imaging with 123-I MIBG on the ...
Tópico(s): Cardiac pacing and defibrillation studies
2010 - Elsevier BV | Journal of the American College of Cardiology
Stephen P. Gray, Jay C. Jha, Kit Kennedy, Erik van Bommel, Phyllis Chew, Cédric Szyndralewiez, Rhian M. Touyz, Harald Schmidt, Mark E. Cooper, Karin Jandeleit‐Dahm,
Oxidative stress is a promising target in diabetes-associated vasculopathies, with inhibitors of NADPH oxidases (NOX), in particular isoforms 1 and 4, shown to be safe in early clinical development. We have explored a highly relevant late-stage intervention protocol using the clinically most advanced compound, the NOX1/4 inhibitor GKT137831, to determine whether end-organ damage can be reversed/attenuated when GKT137831 is administered in the setting of established diabetic complications.GKT137831 ...
Tópico(s): Advanced Glycation End Products research
2017 - Springer Science+Business Media | Diabetologia
Alys Granados, Catherine Sun, Jason T. Fisher, Andrew Ladle, Kimberly Dawe, Christopher Beirne, Mark S. Boyce, Emily Chow, Nicole Heim, Mitchell Fennell, Joanna Klees van Bommel, Robin Naidoo, Michael Procko, Frances E. C. Stewart, A. Cole Burton,
Outdoor recreation is widespread, with uncertain effects on wildlife. The human shield hypothesis (HSH) suggests that recreation could have differential effects on predators and prey, with predator avoidance of humans creating a spatial refuge 'shielding' prey from people. The generality of the HSH remains to be tested across larger scales, wherein human shielding may prove generalizable, or diminish with variability in ecological contexts. We combined data from 446 camera traps and 79,279 sampling ...
Tópico(s): Geographies of human-animal interactions
2023 - Wiley | Ecology and Evolution
Mark M. Boogers, Serge D. Van Kriekinge, Maureen M. Henneman, Claudia Ypenburg, Rutger J. van Bommel, Eric Boersma, Petra Dibbets‐Schneider, Marcel P. M. Stokkel, Martin J. Schalij, Daniel S. Berman, Guido Germano, Jeroen J. Bax,
The significance of left ventricular (LV) dyssynchrony for the prediction of response to cardiac resynchronization therapy (CRT) has been demonstrated. Parameters reflecting LV dyssynchrony (phase SD, histogram bandwidth) can be derived from gated myocardial perfusion SPECT (GMPS) using phase analysis. The feasibility of LV dyssynchrony assessment with phase analysis on GMPS using Quantitative Gated SPECT (QGS) software has not been demonstrated in patients undergoing CRT. The aim of the present study ...
Tópico(s): Advanced MRI Techniques and Applications
2009 - Society of Nuclear Medicine and Molecular Imaging | Journal of Nuclear Medicine
Anne C. Hesp, Mark M. Smits, Erik J.M. van Bommel, Marcel H.A. Muskiet, Lennart Tonneijck, Max Nieuwdorp, Mark H.H. Kramer, Jaap A. Joles, Petter Bjornstad, Daniël H. van Raalte,
Glomerular hyperfiltration plays a key role in the pathophysiology of diabetic kidney disease (DKD). Mechanisms underlying this adverse hemodynamic profile are incompletely understood. We hypothesized that systemic vascular pathology, including endothelial dysfunction and arterial stiffness, relates to glomerular hyperfiltration indicated by filtration fraction (FF). Baseline data of three trials of overweight adults with type 2 diabetes (TD2, n = 111) with relatively well preserved kidney function were ...
Tópico(s): Cardiovascular Function and Risk Factors
2022 - Elsevier BV | Journal of Diabetes and its Complications
Rutger J. van Bommel, John Gorcsan, Eugene Chung, William T. Abraham, F.T. Gjestvang, C. Leclercq, Mark Monaghan, Petros Nihoyannopoulos, Carlo Peraldo, Cheuk‐Man Yu, M. Demas, Bart Gerritse, Jeroen J. Bax,
Introduction Current guidelines recommend cardiac resynchronisation therapy (CRT) in patients with severe symptomatic heart failure, depressed left ventricular (LV) systolic function and a wide QRS complex (≥120 ms). However, patients with heart failure having a narrow QRS complex might also benefit from CRT. Design setting patients interventions During the Predictors of Response to Cardiac Resynchronisation Therapy (PROSPECT) trial, 41 patients were enrolled in a 'narrow' QRS sub-study. These patients had a QRS ...
Tópico(s): Neurological disorders and treatments
2010 - BMJ | Heart