A. J. Alcock, C. DeMichelis, Martin Richardson,
Using a passively Q -switched ruby laser, operating in a single axial and transverse mode, sparks produced in a number of gases at pressures ranging from 760 to 9000 mmHg have been studied. Breakdown threshold measurements for both single and multimode laser radiation have been made and in addition, the characteristics of the sparks produced with single-mode radiation have been investigated. Photography at 90° of the scattered laser light showed the existence of scattering regions with transverse ...
Tópico(s): Laser-induced spectroscopy and plasma
1970 - IEEE Photonics Society | IEEE Journal of Quantum Electronics
Colin C. Collins, Stanislav Volik, Anna Lapuk, Yuwei Wang, Peter W. Gout, Chunxiao Wu, Hui Xue, Hongwei Cheng, Anne Haegert, Robert H. Bell, Sonal Brahmbhatt, Shawn Anderson, Ladan Fazli, Antonio Hurtado‐Coll, Mark A. Rubin, Francesca Demichelis, Himisha Beltran, Martin Hirst, Marco A. Marra, Christopher A. Maher, Arul M. Chinnaiyan, Martin Gleave, Joseph R. Bertino, Martin Lubin, Yuzhuo Wang,
Castrate-resistant prostate cancer (CRPC) and neuroendocrine carcinoma of the prostate are invariably fatal diseases for which only palliative therapies exist. As part of a prostate tumor sequencing program, a patient tumor was analyzed using Illumina genome sequencing and a matched renal capsule tumor xenograft was generated. Both tumor and xenograft had a homozygous 9p21 deletion spanning the MTAP, CDKN2, and ARF genes. It is rare for this deletion to occur in primary prostate tumors, yet approximately ...
Tópico(s): Epigenetics and DNA Methylation
2012 - American Association for Cancer Research | Molecular Cancer Therapeutics
Yi Cheng, Jean-Pierre Veder, Lars Thomsen, Shiyong Zhao, Martin Saunders, Raffaella Demichelis, Chang Liu, Roland De Marco, San Ping Jiang,
The Fe center in FePc can be electrochemically substituted by Co and Ni, achieving high activity and stability for CO 2 reduction.
Tópico(s): Electrocatalysts for Energy Conversion
2017 - Royal Society of Chemistry | Journal of Materials Chemistry A
Himisha Beltran, David S. Rickman, Kyung Park, Sung Suk Chae, Andrea Sboner, Theresa Y. MacDonald, Yuwei Wang, Karen L. Sheikh, Stéphane Terry, Scott T. Tagawa, Rajiv Dhir, Joel B. Nelson, Alexandre de la Taille, Yves Allory, Mark Gerstein, Sven Perner, Kenneth J. Pienta, Arul M. Chinnaiyan, Yuzhuo Wang, Colin C. Collins, Martin Gleave, Francesca Demichelis, David M. Nanus, Mark A. Rubin,
Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that most commonly evolves from preexisting prostate adenocarcinoma (PCA). Using Next Generation RNA-sequencing and oligonucleotide arrays, we profiled 7 NEPC, 30 PCA, and 5 benign prostate tissue (BEN), and validated findings on tumors from a large cohort of patients (37 NEPC, 169 PCA, 22 BEN) using IHC and FISH. We discovered significant overexpression and gene amplification of AURKA and MYCN in 40% of NEPC and 5% of ...
Tópico(s): Ubiquitin and proteasome pathways
2011 - American Association for Cancer Research | Cancer Discovery
Alexander Röth, Guangsheng He, Andrés Brodsky, Chatree Chai‐Adisaksopha, Teresita Dumagay, Roberta Demichelis, Martin Höglund, Richard Kelly, Je‐Hwan Lee, Jun‐ichi Nishimura, Naoshi Obara, Antonio M. Risitano, Anna Gayà, Anita Appius, Brittany Gentile, Raluca Negricea, Zilu Zhang, Simon Buatois, Bing Han,
Background: COMMODORE 2 (NCT04434092) is a global, randomized, open-label, multicenter Phase III trial evaluating the non-inferiority of the C5 complement inhibitor (C5i) crovalimab (crova) vs eculizumab (ecu) in C5i-naive patients (pts) with PNH. Crova enables rapid and sustained C5 inhibition with subcutaneous (SC) self-administration every 4 weeks (Q4W). Aims: To report the efficacy and safety of crova in COMMODORE 2. Methods: Pts with PNH, age ≥18 years, body weight ≥40 kg, lactate dehydrogenase (LDH) ≥ ...
Tópico(s): Platelet Disorders and Treatments
2023 - Wolters Kluwer | HemaSphere
María Virginia Croce, M. Isla-Larrain, Martín Enrique Rabassa, Sandra O. Demichelis, A. Colussi, Marina Crespo, Ezequiel Lacunza, Amada Segal‐Eiras,
An immunohistochemical analysis was employed to determine the expression of carbohydrate antigens associated to mucins in normal epithelia. Tissue samples were obtained as biopsies from normal breast (18), colon (35) and oral cavity mucosa (8). The following carbohydrate epitopes were studied: sialyl-Lewis x, Lewis x, Lewis y, Tn hapten, sialyl-Tn and Thomsen-Friedenreich antigen. Mucins were also studied employing antibodies against MUC1, MUC2, MUC4, MUC5AC, MUC6 and also normal colonic glycolipid. ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2007 - Springer Science+Business Media | Pathology & Oncology Research
David Wilkes, Verena Sailer, Hui Xue, Hongwei Cheng, Colin C. Collins, Martin Gleave, Yuzhuo Wang, Francesca Demichelis, Himisha Beltran, Mark A. Rubin, David S. Rickman,
Defects in genes involved in DNA damage repair (DDR) pathway are emerging as novel biomarkers and targets for new prostate cancer drug therapies. A previous report revealed an association between an exceptional response to cisplatin treatment and a somatic loss of heterozygosity (LOH) of FANCA in a patient with metastatic prostate cancer who also harbored a germline FANCA variant (S1088F). Although germline FANCA mutations are the most frequent alterations in patients with Fanconi anemia, germline ...
Tópico(s): Plant Genetic and Mutation Studies
2017 - Cold Spring Harbor Laboratory Press | Molecular Case Studies
Ariel Osvaldo Zwenger, Martín Enrique Rabassa, Sandra O. Demichelis, Gabriel Blacher Grossman, Amada Segal‐Eiras, María Virginia Croce,
Aim Colorectal cancer (CRC) is one of the most prevalent malignancies in Argentina with 11,043 new cases and 6,596 deaths estimated to have occurred in 2008. The present study was developed to clarify the differential expression of MUC1, MUC2, sLex, and sLea in colorectal cancer patients and their relationship with survival and clinical and histological features. Methods Ninety primary tumor samples and 43 metastatic lymph nodes from CRC patients were studied; follow-up was documented. Twenty-six ...
Tópico(s): Galectins and Cancer Biology
2014 - SAGE Publishing | The International Journal of Biological Markers
Adam Abeshouse, Jaeil Ahn, Rehan Akbani, Adrian Ally, Samirkumar B. Amin, Chris Andry, Matti Annala, Armen Aprikian, Joshua Armenia, Arshi Arora, J. Todd Auman, Miruna Balasundaram, Saianand Balu, Christopher E. Barbieri, Thomas Bauer, Christopher C. Benz, Alain Bergeron, Rameen Beroukhim, Mario Berríos, Adrian Bivol, Tom Bodenheimer, Lori Boice, Arnoud Boot, Rodolfo Borges dos Reis, Paul C. Boutros, Jay Bowen, Reanne Bowlby, Jeffrey M. Boyd, Robert K. Bradley, Anne Breggia, Fadi Brimo, Christopher A. Bristow, Denise Brooks, Bradley M. Broom, Alan H. Bryce, Glenn J. Bubley, Eric Burks, Yaron S.N. Butterfield, M. Button, David Canes, Carlos Gilberto Carlotti, Rebecca Carlsen, Michel Carmel, Peter R. Carroll, Scott L. Carter, Richard W. Cartun, Brett S. Carver, June M. Chan, Matthew T. Chang, Yu Chen, Andrew D. Cherniack, Simone Chevalier, Lynda Chin, Juok Cho, Andy Chu, Eric Chuah, Sudha Chudamani, Kristian Cibulskis, Giovanni Ciriello, Amanda Clarke, Matthew R. Cooperberg, Niall M. Corcoran, Anthony J. Costello, Janet E. Cowan, Daniel Crain, Erin Curley, Kerstin A. David, John A. Demchok, Francesca Demichelis, Noreen Dhalla, Rajiv Dhir, Alexandre A. Doueik, Bettina F. Drake, Heidi Dvinge, Natalya Dyakova, Ina Felau, Martin L. Ferguson, Scott Frazer, Stephen J. Freedland, Yao Fu, Stacey Gabriel, Jianjiong Gao, Johanna Gardner, Julie M. Gastier-Foster, Nils Gehlenborg, Mark Gerken, Mark Gerstein, Gad Getz, Andrew K. Godwin, Anuradha Gopalan, Markus Graefen, Kiley Graim, Thomas Gribbin, Ranabir Guin, Manaswi Gupta, Angela Hadjipanayis, Syed Haider, Lucie Hamel, D. Neil Hayes, David I. Heiman, Julian M. Hess, Katherine A. Hoadley, Andrea Holbrook, Robert A. Holt, Antonia H. Holway, Christopher M. Hovens, Alan P. Hoyle, Mei Huang, Carolyn M. Hutter, Michael Ittmann, Lisa Iype, Joshua M. Stuart, Corbin D. Jones, Steven J.M. Jones, Hartmut Juhl, André Kahles, Christopher J. Kane, L. Sylvia, Michael Kerger, Ekta Khurana, Jaegil Kim, Robert J. Klein, Raju Kucherlapati, Louis Lacombe, Marc Ladanyi, Phillip H. Lai, Peter W. Laird, Eric S. Lander, Mathieu Latour, Michael S. Lawrence, Kevin Lau, Tucker W. LeBien, Darlene Lee, Semin Lee, Kjong-Van Lehmann, Kristen Leraas, Ignaty Leshchiner, Robert Leung, John A. Libertino, Tara M. Lichtenberg, Pei Lin, W. Marston Linehan, Shiyun Ling, Scott M. Lippman, Jia Liu, Wenbin Liu, Lucas Lochovsky, Massimo Loda, Christopher J. Logothetis, Laxmi Lolla, Teri A. Longacre, Yiling Lu, Jianhua Luo, Yussanne Ma, Harshad S. Mahadeshwar, David Mallery, Armaz Mariamidze, Marco A. Marra, Michael Mayo, Shannon J. McCall, Ginette McKercher, Shaowu Meng, Anne‐Marie Mes‐Masson, Maria J. Merino, Matthew Meyerson, Piotr A. Mieczkowski, Gordon B. Mills, Kenna Shaw, Sarah Minner, Alireza Moinzadeh, Richard A. Moore, Scott Morris, Quaid Morris, Lisle E. Mose, Andrew J. Mungall, Bradley A. Murray, Jerome Myers, Rashi Naresh, Joel B. Nelson, Mark A. Nelson, Peter S. Nelson, Yulia Newton, Michael S. Noble, Houtan Noushmehr, Matti Nykter, Angeliki Pantazi, Michael Parfenov, Peter J. Park, Joel S. Parker, Joseph Paulauskis, Robert Penny, Charles M. Perou, Alain Piché, Todd Pihl, Peter A. Pinto, Davide Prandi, Alexei Protopopov, Nilsa C. Ramirez, Arvind Rao, W. Kimryn Rathmell, Gunnar Rätsch, Xiaojia Ren, Victor E. Reuter, Sheila M. Reynolds, Suhn K. Rhie, Kimberly Rieger‐Christ, Jeffrey Roach, A. Gordon Robertson, Brian D. Robinson, Mark A. Rubin, Fred Saad, Sara Sadeghi, Gordon Saksena, Charles Saller, Andrew L. Salner, Francisco Sanchez‐Vega, Chris Sander, George E. Sandusky, Guido Sauter, Andrea Sboner, Peter T. Scardino, Eleonora Scarlata, Jacqueline E. Schein, Thorsten Schlomm, Laura S. Schmidt, Nikolaus Schultz, Steven E. Schumacher, Jonathan G. Seidman, Luciano Neder, Sahil Seth, Alexis Sharp, Candace Shelton, Troy Shelton, Hui Shen, Ronglai Shen, Mark E. Sherman, Margi Sheth, Yan Shi, Juliann Shih, Ilya Shmulevich, Jeffry P. Simko, Ronald Simon, Janae V. Simons, Payal Sipahimalani, Tara Skelly, Heidi J. Sofia, Matthew G. Soloway, Xingzhi Song, Andrea Sorcini, Carrie Sougnez, Serghei Stepa, Chip Stewart, John Stewart, Joshua M. Stuart, Travis Sullivan, Charlie Sun, Huandong Sun, Angela Tam, Donghui Tan, Jiabin Tang, Roy Tarnuzzer, Katherine Tarvin, Barry S. Taylor, Patrick Teebagy, Imelda Tenggara, Bernard Têtu, Ashutosh Tewari, Nina Thiessen, Timothy C. Thompson, Leigh B. Thorne, Daniela Pretti da Cunha Tirapelli, Scott A. Tomlins, Felipe Amstalden Trevisan, Patricia Troncoso, Lawrence D. True, Maria Christina Tsourlakis, Svitlana Tyekucheva, Eliezer M. Van Allen, David Van Den Berg, Umadevi Veluvolu, Roel R.G. Verhaak, Cathy D. Vocke, Doug Voet, Yunhu Wan, Qingguo Wang, Wenyi Wang, Linghua Wang, Nils Weinhold, John N. Weinstein, Daniel J. Weisenberger, Matthew D. Wilkerson, Lisa Wise, John S. Witte, Chia-Chin Wu, Junyuan Wu, Ye Wu,
Summary There is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer Genome Atlas (TCGA), we present a comprehensive molecular analysis of 333 primary prostate carcinomas. Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions ( ERG , ETV1/4 , and FLI1 ) or mutations ( SPOP , FOXA1 , and IDH1 ). Epigenetic profiles showed substantial ...
Cell Press
Dolores Di Vizio, Matteo Morello, Andrew C. Dudley, Peter Schow, Rosalyn M. Adam, Samantha Morley, David J. Mulholland, Mirja Rotinen, Martin H. Hager, Luigi Insabato, Marsha A. Moses, Francesca Demichelis, Michael P. Lisanti, Hong Wu, Michael Klagsbrun, Neil A. Bhowmick, Mark A. Rubin, Crislyn D’Souza‐Schorey, Michael R. Freeman,
Oncosomes are tumor-derived microvesicles that transmit signaling complexes between cell and tissue compartments. Herein, we show that amoeboid tumor cells export large (1- to 10-μm diameter) vesicles, derived from bulky cellular protrusions, that contain metalloproteinases, RNA, caveolin-1, and the GTPase ADP-ribosylation factor 6, and are biologically active toward tumor cells, endothelial cells, and fibroblasts. We describe methods by which large oncosomes can be selectively sorted by flow cytometry ...
Tópico(s): Caveolin-1 and cellular processes
2012 - Elsevier BV | American Journal Of Pathology
Yi Cheng, Amir Memar, Martin Saunders, Jian Pan, Chang Liu, Julian D. Gale, Raffaella Demichelis, Pei Kang Shen, San Ping Jiang,
Dye functionalized double- and triple-walled carbon nanotubes are effective photoanodes for water splitting without the attachment of semiconductor and water oxidation catalysts.
Tópico(s): TiO2 Photocatalysis and Solar Cells
2016 - Royal Society of Chemistry | Journal of Materials Chemistry A
Joanna Cyrta, Anke Augspach, Maria Rosaria De Filippo, Davide Prandi, Phillip Thienger, Matteo Benelli, Victoria Cooley, Rohan Bareja, David Wilkes, Sung-Suk Chae, Paola Cavaliere, Noah Dephoure, Anne-Christine Uldry, Sophie Braga Lagache, Luca Roma, Sandra Cohen, Muriel Jaquet, Laura P. Brandt, Mohammed Alshalalfa, Loredana Puca, Andrea Sboner, Felix Y. Feng, Shangqian Wang, Himisha Beltran, Tamara Lotan, Martin Spahn, Marianna Kruithof‐de Julio, Yu Chen, Karla V. Ballman, Francesca Demichelis, Salvatore Piscuoglio, Mark A. Rubin,
Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10-20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in NEPC. Using large patient datasets, patient-derived organoids and cancer ...
Tópico(s): Mechanisms of cancer metastasis
2020 - Nature Portfolio | Nature Communications
Étienne Dardenne, Himisha Beltran, Matteo Benelli, Kaitlyn Gayvert, Adeline Berger, Loredana Puca, Joanna Cyrta, Andrea Sboner, Zohal Noorzad, Theresa Y. MacDonald, Cynthia Cheung, Ka Shing Yuen, Dong Gao, Yu Chen, Martin Eilers, Juan‐Miguel Mosquera, Brian D. Robinson, Olivier Elemento, Mark A. Rubin, Francesca Demichelis, David S. Rickman,
The transition from castration-resistant prostate adenocarcinoma (CRPC) to neuroendocrine prostate cancer (NEPC) has emerged as an important mechanism of treatment resistance. NEPC is associated with overexpression and gene amplification of MYCN (encoding N-Myc). N-Myc is an established oncogene in several rare pediatric tumors, but its role in prostate cancer progression is not well established. Integrating a genetically engineered mouse model and human prostate cancer transcriptome data, we show ...
Tópico(s): Cancer-related gene regulation
2016 - Cell Press | Cancer Cell
Chuandong Geng, Bin He, Limei Xu, Christopher E. Barbieri, Vijay Kumar Eedunuri, Sue Anne Chew, Martin Zimmermann, Richard A. Bond, John Shou, Chao Li, Mirjam Blattner, David M. Lonard, Francesca Demichelis, Cristian Coarfa, Mark A. Rubin, Pengbo Zhou, Bert W. O’Malley, Nicholas Mitsiades,
The p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2 [nuclear receptor coactivator (NCOA)2], and SRC-3 [amplified in breast cancer 1 (AIB1)/NCOA3] are key pleiotropic “master regulators” of transcription factor activity necessary for cancer cell proliferation, survival, metabolism, and metastasis. SRC overexpression and overactivation occur in numerous human cancers and are associated with poor clinical outcomes and resistance to therapy. In prostate cancer (PC), the p160 SRCs play critical roles ...
Tópico(s): Ubiquitin and proteasome pathways
2013 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Alexander Röth, Guangsheng He, Hongyan Tong, Zenghua Lin, Xiaoqin Wang, Chatree Chai‐Adisaksopha, Je‐Hwan Lee, Andrés Brodsky, Chattree Hantaweepant, Teresita Dumagay, Roberta Demichelis‐Gómez, Ponlapat Rojnuckarin, Jing Sun, Martin Höglund, Jun Ho Jang, Anna Gayà, Fernando Silva, Naoshi Obara, Richard J. Kelly, Leigh Beveridge, Simon Buatois, Sammy Chebon, Brittany Gentile, Pontus Lundberg, Sasha Sreckovic, Jun‐ichi Nishimura, Antonio M. Risitano, Bing Han,
Abstract Crovalimab is a novel C5 complement inhibitor that enables rapid and sustained C5 inhibition with subcutaneous, low‐volume self‐administration every 4 weeks. COMMODORE 2 (NCT04434092) is a global, randomized, open‐label, multicenter, phase 3 trial evaluating the non‐inferiority of crovalimab versus eculizumab in patients with paroxysmal nocturnal hemoglobinuria not previously treated with C5 inhibition. C5 inhibitor‐naive patients with lactate dehydrogenase (LDH) ≥2 × upper limit of normal (ULN) ...
Tópico(s): Renal Diseases and Glomerulopathies
2024 - Wiley | American Journal of Hematology
Martin H. Hager, Samantha Morley, Diane R. Bielenberg, Sizhen Gao, Matteo Morello, Ilona N. Holcomb, Wennuan Liu, Ghassan Mouneimne, Francesca Demichelis, Jayoung Kim, Keith R. Solomon, Rosalyn M. Adam, William B. Isaacs, Henry N. Higgs, Robert L. Vessella, Dolores Di Vizio, Michael R. Freeman,
Abstract Therapies for most malignancies are generally ineffective once metastasis occurs. While tumour cells migrate through tissues using diverse strategies, the signalling networks controlling such behaviours in human tumours are poorly understood. Here we define a role for the Diaphanous‐related formin‐3 (DIAPH3) as a non‐canonical regulator of metastasis that restrains conversion to amoeboid cell behaviour in multiple cancer types. The DIAPH3 locus is close to RB1 , within a narrow consensus region ...
Tópico(s): Signaling Pathways in Disease
2012 - Springer Nature | EMBO Molecular Medicine
Alba Torres, Mohammed Alshalalfa, Scott A. Tomlins, Nicholas Erho, Ewan A. Gibb, Jijumon Chelliserry, Lony Lim, Lucia L.C. Lam, Sheila F. Faraj, Stephania Martins Bezerra, Elai Davicioni, Kasra Yousefi, Ashley E. Ross, George J. Netto, Edward M. Schaeffer, Tamara L. Lotan,
... U. Nagy D. Pestano G. Kunju L.P. Demichelis F. Chinnaiyan A.M. Rubin M.A. Antibody-based detection of ERG rearrangement-positive prostate cancer.Neoplasia. 2010; 12: 590-598Abstract Full Text PDF PubMed Scopus (292) Google Scholar with a very high concordance (>95%) between the two methods in most studies.6Pettersson A. Graff R.E. Bauer S.R. Pitt M.J. Lis R.T. Stack E.C. Martin N.E. Kunz L. Penney K.L. Ligon ...
Tópico(s): Molecular Biology Techniques and Applications
2017 - Elsevier BV | Journal of Molecular Diagnostics
Dolores Di Vizio, Jayoung Kim, Martin H. Hager, Matteo Morello, Wei Yang, Christopher J. Lafargue, Lawrence D. True, Mark A. Rubin, Rosalyn M. Adam, Rameen Beroukhim, Francesca Demichelis, Michael R. Freeman,
Oncosomes have recently been described as membrane-derived microvesicles secreted by cancer cells, which transfer oncogenic signals and protein complexes across cell boundaries. Here, we show the rapid formation and secretion of oncosomes from DU145 and LNCaP human prostate cancer cells. Oncosome formation was stimulated by epidermal growth factor receptor activation and also by overexpression of membrane-targeted Akt1. Microvesicles shed from prostate cancer cells contained numerous signal transduction ...
Tópico(s): Mass Spectrometry Techniques and Applications
2009 - American Association for Cancer Research | Cancer Research
Himisha Beltran, Kenneth Eng, Juan Miguel Mosquera, Alexandros Sigaras, Alessandro Romanel, Hanna Rennert, Myriam Kossaï, Chantal Pauli, Bishoy M. Faltas, Jacqueline Fontugne, Kyung Park, Jason R. Banfelder, Davide Prandi, Neel S. Madhukar, Tuo Zhang, Jessica Padilla, Noah Greco, Terra J. McNary, Erick Herrscher, David Wilkes, Theresa Y. MacDonald, Hui Xue, Vladimir Vacic, Anne-Katrin Emde, Dayna M. Oschwald, Adrian Y. Tan, Zhengming Chen, Colin C. Collins, Martin Gleave, Yuzhuo Wang, Dimple Chakravarty, Marc Schiffman, Robert Kim, Fabien Campagne, Brian D. Robinson, David M. Nanus, Scott T. Tagawa, Jenny Xiang, Agata Smogorzewska, Francesca Demichelis, David S. Rickman, Andrea Sboner, Olivier Elemento, Mark A. Rubin,
Importance Understanding molecular mechanisms of response and resistance to anticancer therapies requires prospective patient follow-up and clinical and functional validation of both common and low-frequency mutations. We describe a whole-exome sequencing (WES) precision medicine trial focused on patients with advanced cancer. Objective To understand how WES data affect therapeutic decision making in patients with advanced cancer and to identify novel biomarkers of response. Design, Setting, and Patients Patients ...
Tópico(s): Colorectal Cancer Treatments and Studies
2015 - American Medical Association | JAMA Oncology
Sameer Jhavar, Alison Reid, Jeremy Clark, Zsofia Kote‐Jarai, Timothy Christmas, Alan Thompson, Christopher Woodhouse, Christopher Ogden, Cyril Fisher, Cathy Corbishley, Johann S. de Bono, Rosalind A. Eeles, Daniel Brewer, Colin Cooper,
... Flohr P Edwards S Foster CS Eeles R Martin FL Phillips DH Crundwell M Christmas T Thompson A Fisher C Kovacs G Cooper CS Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.Oncogene. 2007; 26: 2667-2673Crossref PubMed Scopus (209) Google Scholar7Perner S Demichelis F Beroukhim R Schmidt FH Mosquera J-M ...
Tópico(s): Advanced Proteomics Techniques and Applications
2007 - Elsevier BV | Journal of Molecular Diagnostics
Stefan T. Börno, Axel Fischer, Martin Kerick, Maria Fälth, Mark Laible, Jan C. Brase, Ruprecht Kuner, Andreas Dahl, Christina Grimm, Behnam Sayanjali, Melanie Isau, Christina Röhr, Andrea Wunderlich, Bernd Timmermann, Rainer Claus, Christoph Plass, Markus Graefen, Ronald Simon, Francesca Demichelis, Mark A. Rubin, Guido Sauter, Thorsten Schlomm, Holger Sültmann, Hans Lehrach, Michal R. Schweiger,
Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high-throughput sequencing study investigating genome-wide DNA methylation patterns in a large cohort of 51 tumor and 53 benign prostate samples using methylated DNA immunoprecipitation sequencing. Comparative analyses identified more than 147,000 cancer-associated epigenetic alterations. In addition, ...
Tópico(s): Cancer-related molecular mechanisms research
2012 - American Association for Cancer Research | Cancer Discovery
Tom van der Voorn, Caroline van den Berg, Prosun Bhattacharya, Jaco Quist,
... Caruso, A.; Costamagna, E.; Ridolfi, L.; Fiore, S.; Demichelis, F.; Galvão, A.; Pisoeiro, J.; Rizzo, A.; Masi, ... Caruso, Alice; Costamagna, Elisa; Ridolfi, Luca; Fiore, Silvia; Demichelis, Francesca; Galvao, Ana; Pisoeiro, Joana; Rizzo, Anacleto; Masi, ... Caruso, A.; Costamagna, E.; Ridolfi, L.; Fiore, S.; Demichelis, F.; Galvão, A.; Pisoeiro, J.; Rizzo, A.; Masi, ... Caruso, Alice; Costamagna, Elisa; Ridolfi, Luca; Fiore, Silvia; Demichelis, Francesca; Galvao, Ana; Pisoeiro, Joana; Rizzo, Anacleto; Masi, ...
Tópico(s): Water-Energy-Food Nexus Studies
2020 - American Chemical Society | ACS ES&T Water
Kerstin Heselmeyer‐Haddad, Lissa Y. Berroa Garcia, Allan Bradley, Leanora S. Hernandez, Yue Hu, Jens K. Habermann, Christoph Dumke, Christoph Thorns, Sven Perner, Ekaterina Pestova, Catherine Burke, Salim A. Chowdhury, Russell Schwartz, Alejandro A. Schäffer, Pamela L. Paris, Thomas Ried,
... 648Crossref PubMed Scopus (3147) Google Scholar, 10Perner S. Demichelis F. Beroukhim R. Schmidt F.H. Mosquera J. ... U. Nagy D. Pestano G. Kunju L.P. Demichelis F. Chinnaiyan A.M. Rubin M.A. Antibody- ... apart probe for the TMPRSS2-ERG fusion10Perner S. Demichelis F. Beroukhim R. Schmidt F.H. Mosquera J. ...
Tópico(s): Cancer-related molecular mechanisms research
2014 - Elsevier BV | American Journal Of Pathology
Rahul Aggarwal, Jiaoti Huang, Joshi J. Alumkal, Li Zhang, Felix Y. Feng, George Thomas, Alana S. Weinstein, Verena Friedl, Can Zhang, Owen N. Witte, Paul Lloyd, Martin Gleave, Christopher P. Evans, Jack Youngren, Tomasz M. Beer, Matthew B. Rettig, Christopher K. Wong, Lawrence D. True, Adam Foye, Denise Playdle, Charles J. Ryan, Primo Lara, Kim N., Vlado Uzunangelov, Artem Sokolov, Yulia Newton, Himisha Beltran, Francesca Demichelis, Mark A. Rubin, Joshua M. Stuart, Eric J. Small,
Purpose The prevalence and features of treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) are not well characterized in the era of modern androgen receptor (AR)-targeting therapy. We sought to characterize the clinical and genomic features of t-SCNC in a multi-institutional prospective study. Methods Patients with progressive, metastatic castration-resistant prostate cancer (mCRPC) underwent metastatic tumor biopsy and were followed for survival. Metastatic biopsy specimens underwent ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2018 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Andrew J. Armstrong, Emmanuel S. Antonarakis, Mary‐Ellen Taplin, William Kevin Kelly, Himisha Beltran, Karim Fizazi, William L. Dahut, Neal D. Shore, Susan F. Slovin, Daniel J. George, Michael A. Carducci, Paul G. Corn, Daniel C. Danila, Robert Dreicer, Elisabeth I. Heath, Dana E. Rathkopf, Guoqiang Liu, David M. Nanus, Mark N. Stein, Mitchell R. Smith, Cora N. Sternberg, George Wilding, Peter S. Nelson, Susan Halabi, Philip W. Kantoff, Noel W. Clarke, Christopher P. Evans, Axel Heidenreich, Nicolas Mottet, Martin Gleave, Michael J. Morris, Howard I. Scher,
... Google Scholar, 11.Rickman D.S. Beltran H. Demichelis F. Rubin M.A. Biology and evolution of ... favorable outcome [11.Rickman D.S. Beltran H. Demichelis F. Rubin M.A. Biology and evolution of ...
Tópico(s): Cancer, Lipids, and Metabolism
2017 - Elsevier BV | Annals of Oncology
Julia F. Riley, Thuy P. Dao, Carlos A. Castañeda,
... C.E. Baca S.C. Lawrence M.S. Demichelis F. Blattner M. Theurillat J.-P. White T. ... Otero J.H. Scott D.C. Szulc E. Martin E.W. Sabri N. Granata D. Marzahn M. ... Otero J.H. Scott D.C. Szulc E. Martin E.W. Sabri N. Granata D. Marzahn M. ... Otero J.H. Scott D.C. Szulc E. Martin E.W. Sabri N. Granata D. Marzahn M. ... Otero J.H. Scott D.C. Szulc E. Martin E.W. Sabri N. Granata D. Marzahn M. ...
Tópico(s): Lipid metabolism and biosynthesis
2018 - Elsevier BV | Molecular Cell
... Pediatr. 1980; 96: 699– 701. 55 Imazio M, Demichelis B, Parrini I, et al. Management, risk factors, ... AL. Pericarditis. Lancet. 2004; 363: 717– 727. 58 Martin RG, Ruckdeschel JC, Chang P, Byhardt R, Bouchard ...
Tópico(s): Myasthenia Gravis and Thymoma
2011 - Wiley | Congenital Heart Disease
Cheryl M. Koh, Bora Gürel, Siobhan Sutcliffe, Martin J. Aryee, Denise Schultz, Tsuyoshi Iwata, Motohide Uemura, Karen Zeller, Uzoma A. Anele, Qizhi Zheng, Jessica Hicks, William G. Nelson, Chi V. Dang, Srinivasan Yegnasubramanian, Angelo M. De Marzo,
... U. Nagy D. Pestano G. Kunju L.P. Demichelis F. Chinnaiyan A.M. Rubin M.A. Antibody- ...
Tópico(s): Cancer, Lipids, and Metabolism
2011 - Elsevier BV | American Journal Of Pathology
Francesca Demichelis, Sunita R. Setlur, Samprit Banerjee, Dimple Chakravarty, Jin Yun Helen Chen, Chen X. Chen, Julie Huang, Himisha Beltran, Derek A. Oldridge, Naoki Kitabayashi, Birgit Stenzel, Georg Schaefer, Wolfgang Horninger, Jasmin Bektić, Arul M. Chinnaiyan, Sagit Goldenberg, Javed Siddiqui, Meredith M. Regan, Michale Kearney, T. David Soong, David S. Rickman, Olivier Elemento, John T. Wei, Douglas S. Scherr, Martin A. Sanda, Georg Bartsch, Charles Lee, Helmut Klocker, Mark A. Rubin,
Copy number variants (CNVs) are a recently recognized class of human germ line polymorphisms and are associated with a variety of human diseases, including cancer. Because of the strong genetic influence on prostate cancer, we sought to identify functionally active CNVs associated with susceptibility of this cancer type. We queried low-frequency biallelic CNVs from 1,903 men of Caucasian origin enrolled in the Tyrol Prostate Specific Antigen Screening Cohort and discovered two CNVs strongly associated ...
Tópico(s): Epigenetics and DNA Methylation
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Thomas Stefan Worst, Jost von Hardenberg, Julia Christina Gross, Philipp Erben, Martina Schnölzer, Ingrid Haußer, Peter Bugert, Maurice Stephan Michel, Michael Boutros,
... C.E. Baca S.C. Lawrence M.S. Demichelis F. Blattner M. Theurillat J.-P. White T. ...
Tópico(s): Cancer-related molecular mechanisms research
2017 - Elsevier BV | Molecular & Cellular Proteomics