José M. Lasarte, L. Martín, Elisa Langa, José S. Urieta, Ana M. Mainar,
A measuring device, based on the vibrating tube principle, for measuring PρT data is described. The device was checked against the recommended literature values of the 1-hexanol + n-hexane binary system within the temperature and pressure ranges (278.15 to 313.15) K and (0.1 to 20) MPa. The relative deviations between experimental and bibliographic densities are lower than 0.2 %. After the validation, the original mixture 1,8-cineole + ethanol was studied in the ranges (283.15 to 313.15) K and (0.1 to 20) ...
Tópico(s): Chemical Thermodynamics and Molecular Structure
2008 - American Chemical Society | Journal of Chemical & Engineering Data
M.J. Lozano de la Torre, Carmen Rosa Pallás Alonso, María-Teresa Hernández-Aguilar, Josefa Aguayo Maldonado, José Arena Ansótegui, Susana Ares Segura, A Gómez Papí, N. Marta Díaz‐Gómez, A. Jiménez Moya, Leonardo Landa Rivera, Juan José Lasarte Velillas, J. Martín-Calama Valero, Miriam M. Morales, J. M. Paricio Talayero, M. D. Romero Escós,
Pacifiers are widely used in developed societies. They are used for soothing infants, reducing their stress and pain during procedures and to help them sleep. The use of pacifiers has been associated, however, with a shorter duration and exclusivity of breastfeeding, with higher rates of otitis media and dental problems, as well as a higher risk of accidents during infancy. Recent studies have also described a relationship between pacifier use and SIDS, especially when used during infant́s sleep. ...
Tópico(s): Breastfeeding Practices and Influences
2011 - Elsevier BV | Anales de Pediatría
Noelia Silva-Pilipich, Aritz Lasarte-Cía, Teresa Lozano, Celia Martín-Otal, Juan José Lasarte, Cristian Smerdou,
Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for antitumor therapy. These vectors are usually delivered as viral particles, but it is also possible to administer them as RNA. We evaluated this possibility by in vivo electroporation of Semliki Forest virus (SFV) saRNA for local treatment of murine colorectal MC38 subcutaneous tumors. Optimization of saRNA electroporation ...
Tópico(s): Virus-based gene therapy research
2022 - Cell Press | Molecular Therapy — Nucleic Acids
Raquel Sánchez‐Díaz, Rafael Blanco-Domínguez, Sandra Lasarte, Katerina Tsilingiri, Enrique Martín‐Gayo, Beatriz Linillos-Pradillo, Hortensia de la Fuente, Francisco Sánchez‐Madrid, Rinako Nakagawa, Marı́a L. Toribio, Pilar Martı́n,
Thymus-derived regulatory T (tTreg) cells are key to preventing autoimmune diseases, but the mechanisms involved in their development remain unsolved. Here, we show that the C-type lectin receptor CD69 controls tTreg cell development and peripheral Treg cell homeostasis through the regulation of BIC/microRNA 155 (miR-155) and its target, suppressor of cytokine signaling 1 (SOCS-1). Using Foxp3-mRFP/cd69+/- or Foxp3-mRFP/cd69-/- reporter mice and short hairpin RNA (shRNA)-mediated silencing and miR-155 ...
Tópico(s): Immunotherapy and Immune Responses
2017 - Taylor & Francis | Molecular and Cellular Biology
María-Teresa Hernández-Aguilar, Juan José Lasarte-Velillas, J Martín-Calama, Beatriz Flores-Antón, Cintia Borja-Herrero, María García-Franco, Victoria Navas-Lucena, Carmen Rosa Pallás‐Alonso,
The Baby-Friendly Initiative (BFI-Spain) was founded in 1995 by members of key professional associations (pediatricians, midwives, obstetricians, and nurses) and some mother-to-mother support groups. The United Nations International Children’s Fund was instrumental in supporting the establishment of BFI-Spain as a not-for-profit organization. In 2007, the need for change was identified. A detailed analysis of BFI-Spain identified its main strengths, weaknesses, opportunities, and threats. A new strategic ...
Tópico(s): Infant Development and Preterm Care
2014 - SAGE Publishing | Journal of Human Lactation
MT Hernández Aguilar, A. Muñoz Guillén, JJ Lasarte Velillas, César García Vera, C Díaz Marijuan, J. Martín Calama,
MT. Hernandez Aguilar, A. Munoz Guillen, JJ. Lasarte Velillas, C. Garcia Vera, C. Diaz Marijuan, J. Martin Calama Pediatra. Consultorio Auxiliar de Carretera de Artes. Valencia. Pediatra. Jefe de Seccion de Neonatologia. Hospital Infantil La Fe. Valencia. Pediatra. Centro de ...
Tópico(s): Tracheal and airway disorders
2004 - Lúa Ediciones | Pediatría Atención Primaria
Marta Plumed Lasarte, Diana Gómez Bruna, Clara Martín Duque,
En el mercado turístico actual, la alta competencia existente entre los destinos lleva a sus responsables a invertir dinero, tiempo y esfuerzo en tratar de transmitir una buena imagen, para lo cual se desarrollan importantes estrategias de promoción. En el caso objeto de estudio del presente trabajo, España, la promoción turística del país llevada a cabo a nivel internacional desde el gobierno central ha jugado un papel importante en el desarrollo y crecimiento de España como destino turístico, ...
Tópico(s): Cruise Tourism Development and Management
2018 - Politecnica Salesiana University | Retos
Laura Salinas-Muñoz, Raúl Campos-Fernández, Irene Olivera, Enrique Mercader, Carlota Fernández-Pacheco, Sandra Lasarte, L. Pérez-Martín, M.T. Navarro-González, Paloma Sánchez‐Mateos, Rafael Samaniego, Miguel Relloso,
Female reproductive mucosa must allow allogenic sperm survival whereas at the same time, avoid pathogen infection. To preserve sperm from neutrophil attack, neutrophils disappear from the vagina during the ovulatory phase (high estradiol); although the mechanisms that regulate neutrophil influx to the vagina during insemination remain controversial. We investigated the sex hormone regulation of the neutrophil migration through the cervix during insemination and revealed that ovulatory estradiol dose ...
Tópico(s): Preterm Birth and Chorioamnionitis
2019 - Elsevier BV | Journal of Reproductive Immunology
Celia Martín-Otal, Aritz Lasarte-Cía, Diego Serrano, Noëlia Casares, Enrique Conde, Flor Navarro, Inés Sánchez-Moreno, Marta Gorraiz, Patricia Sarrión, Alfonso Calvo, Carlos E. de Andrea, José I. Echeveste, Amaia Vilas‐Zornoza, Juan R. Rodríguez-Madoz, Jesús F. San Miguel, Felipe Prósper, Sandra Hervás‐Stubbs, Juan José Lasarte, Teresa Lozano,
Background One of the main difficulties of adoptive cell therapies with chimeric antigen receptor (CAR)-T cells in solid tumors is the identification of specific target antigens. The tumor microenvironment can present suitable antigens for CAR design, even though they are not expressed by the tumor cells. We have generated a CAR specific for the splice variant extra domain A (EDA) of fibronectin, which is highly expressed in the tumor stroma of many types of tumors but not in healthy tissues. Methods ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2022 - BMJ | Journal for ImmunoTherapy of Cancer
Flor Navarro, Noëlia Casares, Celia Martín-Otal, Aritz Lasarte-Cía, Marta Gorraiz, Patricia Sarrión, Diana Llópiz, David Repáraz, Nerea Varo, Juan R. Rodríguez-Madoz, Felipe Prósper, Sandra Hervás‐Stubbs, Teresa Lozano, Juan José Lasarte,
The high metabolic activity and insufficient perfusion of tumors leads to the acidification of the tumor microenvironment (TME) that may inhibit the antitumor T cell activity. We found that pharmacological inhibition of the acid loader chloride/bicarbonate anion exchanger 2 (Ae2), with 4,4'-diisothiocyanatostilbene-2,2'-disulfonicacid (DIDS) enhancedCD4+ andCD8+ T cell function upon TCR activation in vitro, especially under low pH conditions. In vivo, DIDS administration delayed B16OVA tumor growth ...
Tópico(s): Adenosine and Purinergic Signaling
2022 - Landes Bioscience | OncoImmunology
Teresa Lozano, Silvia Chocarro, Celia Martín-Otal, Aritz Lasarte-Cía, Cynthia del Valle, Marta Gorraiz, Patricia Sarrión, Marina Ruiz de Galarreta, Amaia Lujambio, Sandra Hervás‐Stubbs, Pablo Sarobe, Noëlia Casares, Juan José Lasarte,
Adoptive immunotherapy with ex vivo-expanded tumor-infiltrating lymphocytes (TILs) has achieved objective clinical responses in a significant number of patients with cancer. The failure of many patients to develop long-term tumor control may be, in part, due to exhaustion of transferred T cells in the presence of a hostile tumor microenvironment. In several tumor types, growth and survival of carcinoma cells appear to be sustained by a network of receptors/ligands of the ErbB family. We speculated ...
Tópico(s): Immunotherapy and Immune Responses
2019 - Frontiers Media | Frontiers in Immunology
Aritz Lasarte-Cía, Teresa Lozano, David Cano, Celia Martín-Otal, Flor Navarro, Marta Gorraiz, Noëlia Casares, Isabel Vivas, Juan José Lasarte,
Background/Aim. Irreversible electroporation (IRE) showed promising results for small-size tumors and very early cancers. However, further development is needed to evolve this procedure into a more efficient ablation technique for long-term control of tumor growth. In this work, we show that it is possible to increase the antitumor efficiency of IRE by simmultaneously injecting c-di-GMP, a STING agonist, intratumorally. Materials and Methods. Intratumoral administration of c-di-GMP simultaneously ...
Tópico(s): Viral gastroenteritis research and epidemiology
2021 - Hindawi Publishing Corporation | BioMed Research International
Eva Gato, Paula Guijarro-Sánchez, Isaac Alonso-García, Rosa Pedraza-Merino, Adrián Ambroa Conde, Emilio Lence, Soraya Rumbo‐Feal, Andrea Peña-Escolano, Cristina Lasarte-Monterrubio, Tania Blanco-Martín, Ana Fernández-González, María del Carmen Fernández-López, Romina Maceiras, Marta Martínez-Guitián, Juan Carlos Vázquez-Ucha, Luis Martínez‐Martínez, Concepción González‐Bello, Jorge Arca-Suárez, Alejandro Beceiro, Germán Bou,
In order to inform and anticipate potential strategies aimed at combating KPC-producing Klebsiella pneumoniae infections, we analysed imipenem/relebactam and ceftazidime/avibactam single-step mutant frequencies, resistance development trajectories, differentially selected resistance mechanisms and their associated fitness cost using four representative high-risk K. pneumoniae clones. Mutant frequencies and mutant preventive concentrations were determined using agar plates containing incremental ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2023 - Elsevier BV | International Journal of Antimicrobial Agents
Diego Salas‐Benito, Enrique Conde, Ibón Tamayo, Uxua Mancheño, Edurne Elizalde, David García-Ros, José Manuel Aramendía, Juan Carlos Muruzábal, Julia Alcaide, Francisco Guillén‐Grima, José Ángel Mínguez, Jose Amores-Tirado, Antonio González‐Martín, Pablo Sarobe, Juan José Lasarte, Mariano Ponz‐Sarvisé, Carlos E. de Andrea, Sandra Hervás‐Stubbs,
Abstract Background Adoptive immunotherapy with tumour-infiltrating lymphocytes (TIL) may benefit from the use of selective markers, such as PD-1, for tumour-specific T-cell enrichment, and the identification of predictive factors that help identify those patients capable of rendering tumour-reactive TILs. We have investigated this in ovarian cancer (OC) patients as candidates for TIL therapy implementation. Methods PD-1 − and PD-1 + CD8 TILs were isolated from ovarian tumours and expanded cells were ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Springer Nature | British Journal of Cancer
Teresa Lozano, Enrique Conde, Celia Martín-Otal, Flor Navarro, Aritz Lasarte-Cía, Rabab Nasrallah, Diego Alignani, Marta Gorraiz, Pablo Sarobe, Juan P. Romero, Amaia Vilas‐Zornoza, Rahul Roychoudhuri, Sandra Hervás‐Stubbs, Noëlia Casares, Juan José Lasarte,
Adoptive cell transfer therapy using CD8+ T lymphocytes showed promising results eradicating metastatic malignancies. However, several regulatory mechanisms limit its efficacy. We studied the role of the expression of the transcription factor FOXP3 on CD8+ T cell function and anti-tumor immunity. Here we show that suboptimal T cell receptor stimulation of CD8+ T cells upregulates FOXP3 in vitro. Similarly, CD8 T cells transferred into tumor-bearing mice upregulate FOXP3 in vivo. Cell-intrinsic loss ...
Tópico(s): T-cell and B-cell Immunology
2021 - Elsevier BV | Cancer Letters
Marcello Di Martino, Ismael Mora‐Guzmán, Víctor Vaello Jodrá, Alfonso Sanjuanbenito Dehesa, Dieter Morales-García, R Caiña Ruiz, Francisca García‐Moreno, Fernando Mendoza Moreno, S. Alonso Batanero, José Edecio Quiñones Sampedro, Paola Lora Cumplido, A Arango Bravo, Inés Rubio-Pérez, Luis Asensio-Gómez, Fernando Pardo Aranda, Sara Sentí Farrarons, Cristina Ruiz Moreno, Clara Maria Martinez Moreno, Aingeru Sarriugarte Lasarte, Mikel Prieto Calvo, Daniel Aparicio-Sánchez, Eduardo Perea del Pozo, Gianluca Pellino, Elena Martín‐Pérez,
Tópico(s): Pancreatic and Hepatic Oncology Research
2021 - Springer Science+Business Media | Journal of Gastrointestinal Surgery
A. Martín, Marta Herránz, Yurena Navarro, Sandra Lasarte, María José Serrano, Emilio Bouza, Darı́o Garcı́a de Viedma,
Molecular analysis of recurrent tuberculosis has revealed that a second episode may be caused by a strain of Mycobacterium tuberculosis other than that involved in the first infection, thus indicating that exogenous reinfection plays a role in recurrence. We focused on two aspects of reinfection that have received little attention. First, we evaluated whether a lack of methodological refinement could lead to inaccurate assignment of mixed infections as exogenous reinfection, in which a differential ...
Tópico(s): Infectious Diseases and Tuberculosis
2011 - American Society for Microbiology | Journal of Clinical Microbiology
Inés Sánchez-Moreno, Aritz Lasarte-Cía, Celia Martín-Otal, Noëlia Casares, Flor Navarro, Marta Gorraiz, Patricia Sarrión, Sandra Hervás‐Stubbs, Lorea Jordana, Juan R. Rodríguez-Madoz, Jesús F. San Miguel, Felipe Prósper, Juan José Lasarte, Teresa Lozano,
Background Adoptive cell therapy using genetically modified T cells to express chimeric antigen receptors (CAR-T) has shown encouraging results, particularly in certain blood cancers. Nevertheless, over 40% of B cell malignancy patients experience a relapse after CAR-T therapy, likely due to inadequate persistence of the modified T cells in the body. IL15, known for its pro-survival and proliferative properties, has been suggested for incorporation into the fourth generation of CAR-T cells to enhance ...
Tópico(s): Virus-based gene therapy research
2024 - BMJ | Journal for ImmunoTherapy of Cancer
Francisco González‐Vílchez, Luis Almenar‐Bonet, María G. Crespo‐Leiro, Manuel Gómez‐Bueno, José González‐Costello, Félix Perez‐Villa, Juan F. Delgado, José María Arizón del Prado, José Manuel Sobrino‐Márquez, María Jesús Valero‐Masa, Manuel Cobo-Belaustegui, Miguel Llano-Cardenal, José A. Vázquez de Prada, Francisco Nistal-Herrera, José Luis Lambert, Beatriz Díaz‐Molina, Cristina Fidalgo-Muñiz, Diego Rangel‐Sousa, Antonio Grande‐Trillo, Vicens Brossa-Loidi, Sònia Mirabet, Laura López, Isabel Zegrí, Marta de Antonio, M. Castel, Marta Farrero, Nicolás Manito, Carles Garcia Díez, Elena García‐Romero, Josep Roca, Javier Castrodeza, Iago Sousa, Zorba Blázquez‐Bermejo, Eduardo Zataraín-Nicolás, Jorge García-Carreño, Paula Navas, Míriam Juárez, Carlos Ortíz, Manuel Martínez‐Sellés, Mónica Santos Cebrián, Raquel López-Viella, Ignacio Sánchez‐Lázaro, S. del Carmen Martínez, Víctor Donoso, Luis Martínez, Amador López‐Granados, Javier Segovia, Francisco Hernández‐Pérez, Cristina Mitroi, Mercedes Rivas‐Lasarte, María Dolores García‐Cosío Carmena, L. Fernández, Pedro Caravaca Pérez, Juan Carlos López‐Azor, María J. Paniagua‐Martín, Eduardo Barge‐Caballero, Gonzalo Barge‐Caballero, David Couto‐Mallón, José J. Cuenca‐Castillo, José M. Herrera-Noreña, Luis García‐Guereta, Óscar González Fernández, Inés Ponz de Antonio, Carlos Labrandero de Lera, Álvaro González, Luz Polo-López, Manuela Camino‐López, Nuria Gil-Villanueva, Luis de la Fuente, Javier Tobar-Ruiz, Iris P. Garrido‐Bravo, Domingo A. Pascual‐Figal, Francisco J. Pastor‐Pérez, Teresa Blasco‐Peiró, Ana Pórtoles-Ocampo, María Lasala-Alastuey, Gregorio Rábago, Rebeca Manrique-Antón, Leticia Jimeno-San Martín, Antonio García Quintana, María del Val Groba-Marco, Mario Galván-Ruiz, Ferrán Gran, Paola Dolader,
Tópico(s): Mechanical Circulatory Support Devices
2021 - Elsevier BV | Revista Española de Cardiología
Ana I. Camacho, Raquel Da Costa Martins, Ibai Tamayo, Juliana de Souza Rebouças, Juan José Lasarte, Cristina Mansilla, Irene Esparza, Juan M. Irache, Carlos Gamazo,
Adjuvant research is being oriented to TLR-agonists, but complement activation has been relatively unexplored. In previous studies it was demonstrated that poly(methyl vinyl ether-co-maleic anhydride) nanoparticles (PVMA NPs) used as adjuvant differentially activate dendritic cells through toll like receptors (TLR) stimulation, however, a high dose of these NPs was used. Now, we demonstrated a dose–response effect, with a concentration as low as 20 μg/mL able to stimulate TLR2 and TLR4 transfected ...
Tópico(s): Immune Response and Inflammation
2011 - Elsevier BV | Vaccine
Eusebio García‐Izquierdo, Susana Mingo‐Santos, Consuelo Olivo-Rodríguez, Vanessa Moñivas‐Palomero, Mercedes Rivas‐Lasarte, Carlos E. Martín-López, Silvia Rosado, Antonio Sánchez, Juan Miguel Redondo, Fernando Rodríguez‐Pascual, Javier Segovia, Alberto Forteza Gil,
Increased collagen cross-linking (CCL) has been described in hypertensive cardiomyopathy by means of reduced serum ratio of serum carboxyterminal telopeptide of collagen type I (CITP) to matrix metalloproteinase-1 (MMP1). Previous studies have demonstrated the existence of primary impaired diastole in patients with Marfan syndrome (MFS), but little is known about the pathophysiology of this condition.60 MFS patients (without previous cardiovascular surgery or significant valvular regurgitation) and 24 ...
Tópico(s): Cardiac Valve Diseases and Treatments
2022 - Elsevier BV | International Journal of Cardiology
Leonardo Landa Rivera, N. Marta Díaz‐Gómez, A. Gómez Papi, J. M. Paricio Talayero, Carmen Pallás Alonso, María-Teresa Hernández-Aguilar, Josefa Aguayo Maldonado, J. M. Arena Ansotegui, Susana Ares Segura, A. Jiménez Moya, Juan José Lasarte Velillas, J. Martín Calama, M. D. Romero Escós,
La práctica de los padres de dormir junto a sus hijos ha sido una constante en la humanidad.Con el aumento en la prevalencia y duración de la lactancia materna, se ha observado paralelamente un aumento de esa práctica, que posiblemente se dé con más frecuencia que la reconocida en las encuestas.Los estudios han demostrado interrelación y mutua potenciación entre lactancia materna y colecho.Las asociaciones y organizaciones pediátricas recomiendan evitar el colecho, por relacionarlo con la muerte ...
Tópico(s): Infant Health and Development
2012 - Lúa Ediciones | Pediatría Atención Primaria
Noelia Silva-Pilipich, Aritz Lasarte-Cía, Juan José Lasarte, Cristian Smerdou,
... 6Silva-Pilipich N. Lasarte-Cía A. Lozano T. Martín-Otal C. Lasarte J.J. Smerdou C. Intratumoral electroporation of a ...
Tópico(s): Microfluidic and Bio-sensing Technologies
2024 - Cell Press | Molecular Therapy — Nucleic Acids
Lucía González-Pinto, Isaac Alonso-García, Tania Blanco-Martín, Pablo Camacho‐Zamora, Pablo A. Fraile-Ribot, Michelle Outeda-García, Cristina Lasarte-Monterrubio, Paula Guijarro-Sánchez, Romina Maceiras, Bartolomé Moyá, Carlos Juan, Juan Carlos Vázquez-Ucha, Alejandro Beceiro, Antonio Oliver, Germán Bou, Jorge Arca-Suárez,
Abstract Objectives We aimed to compare the stability of the newly developed β-lactams (cefiderocol) and β-lactam/β-lactamase inhibitor combinations (ceftazidime/avibactam, ceftolozane/tazobactam, aztreonam/avibactam, cefepime/taniborbactam, cefepime/zidebactam, imipenem/relebactam, meropenem/vaborbactam, meropenem/nacubactam and meropenem/xeruborbactam) against the most clinically relevant mechanisms of mutational and transferable β-lactam resistance in Pseudomonas aeruginosa. Methods We screened ...
Tópico(s): Infections and bacterial resistance
2024 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Marcello Di Martino, Ismael Mora‐Guzmán, Víctor Vaello Jodrá, Alfonso Sanjuanbenito Dehesa, Dieter Morales-García, R Caiña Ruiz, Francisca García‐Moreno, Fernando Mendoza‐Moreno, S. Alonso Batanero, José Edecio Quiñones Sampedro, Paola Lora Cumplido, A Arango Bravo, Inés Rubio-Pérez, Luis Asensio-Gómez, Fernando Pardo Aranda, Sara Sentí Farrarons, Cristina Ruiz Moreno, Clara Maria Martinez Moreno, Aingeru Sarriugarte Lasarte, Mikel Prieto Calvo, Daniel Aparicio-Sánchez, Eduardo Perea del Pozo, Elena Martín‐Pérez,
Tópico(s): Abdominal Trauma and Injuries
2020 - Springer Science+Business Media | Updates in Surgery
Celia Martín-Otal, Flor Navarro, Noëlia Casares, Aritz Lasarte-Cía, Inés Sánchez-Moreno, Sandra Hervás‐Stubbs, Teresa Lozano, Juan José Lasarte,
Recent advances in immunotherapy have revolutionized the treatment of cancer. The use of adoptive cell therapies (ACT) such as those based on tumor infiltrating lymphocytes (TILs) or genetically modified cells (transgenic TCR lymphocytes or CAR-T cells), has shown impressive results in the treatment of several types of cancers. However, cancer cells can exploit mechanisms to escape from immunosurveillance resulting in many patients not responding to these therapies or respond only transiently. The ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2022 - Elsevier BV | International review of cell and molecular biology
J Martín-Calama, Jose Buftuel, M. Teresa Valero, M Labay, Juan José Lasarte, F. R. DEL VALLE, Cristina de Miguel,
In order to determine the effect of feeding glucose water on breastfeeding newborns, we randomly distributed 180 normal newborns into two groups: a glucose water group (GW), fed 5% glucose solution during the first 3 days of life in addition to being breastfed; and an exclusively breastfed nonglucose water group (NGW). The following data were evaluated: weight at 6, 12, 24, 48, and 72 hours of life; temperature during the first 72 hours of life; serum glucose level at 6, 12, 24, and 48 hours; total ...
Tópico(s): Gestational Diabetes Research and Management
1997 - SAGE Publishing | Journal of Human Lactation
Juan Carlos Vázquez-Ucha, Alejandro Seoane-Estévez, Bruno K. Rodiño‐Janeiro, Mónica González-Bardanca, Kelly Conde‐Pérez, Marta Martínez-Guitián, Laura Álvarez-Fraga, Jorge Arca-Suárez, Cristina Lasarte-Monterrubio, Marta Gut, Marta Gut, Miguel Álvarez-Tejado, Marina Oviaño, Alejandro Beceiro, Germán Bou, Irene Merino, Emilia Cercenado, Rosa Gómez, Tamara Soler, Irene Gracia-Ahufinger, L. Hibberd Martin, Fátima Galán‐Sánchez, Nuria Tormo, Juan Carlos Rodrı́guez, Sílvia Capilla, Francesc Marco, María Dolores Quesada, Emma Padilla, Fé Tubau, Juanjo González, Ana Isabel López‐Calleja, José Luís del Pozo, María Inmaculada García, Mariela Martínez, Jorge Calvo, Xavier Mulet, F. J. García Peña, Ana Isabel Rodríguez, María José Gude, Ana Fernández‐Palacín, Javier Fernández,
Imipenem/relebactam is a novel carbapenem/β-lactamase inhibitor combination, developed to act against carbapenemase-producing Enterobacterales (CPE).To assess the in vitro activity of imipenem/relebactam against a Spanish nationwide collection of CPE by testing the susceptibility of these isolates to 16 widely used antimicrobials and to determine the underlying β-lactam resistance mechanisms involved and the molecular epidemiology of carbapenemases in Spain.Clinical CPE isolates (n = 401) collected ...
Tópico(s): Pneumonia and Respiratory Infections
2021 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Marcello Di Martino, Alvaro Quintana, Víctor Vaello Jodrá, Alfonso Sanjuanbenito Dehesa, Dieter Morales-García, R Caiña Ruiz, Francisca García‐Moreno, Fernando Mendoza‐Moreno, S. Alonso Batanero, José Edecio Quiñones Sampedro, Paola Lora Cumplido, A Arango Bravo, Inés Rubio-Pérez, Luis Asensio-Gómez, Fernando Pardo Aranda, Sara Sentí Farrarons, Cristina Ruiz Moreno, Clara Maria Martinez Moreno, Aingeru Sarriugarte Lasarte, Mikel Prieto Calvo, Daniel Aparicio-Sánchez, Eduardo Perea Perea del Pozo, Gianluca Pellino, Elena Martín‐Pérez,
Tópico(s): Diverticular Disease and Complications
2022 - Springer Science+Business Media | Updates in Surgery
Paula Rodríguez-Márquez, María Eréndira Calleja-Cervantes, Guillermo Serrano, Aina Oliver‐Caldés, María Luisa Palacios-Berraquero, Ángel Martín-Mallo, Cristina Calviño, Marta Español‐Rego, Candela Ceballos, Teresa Lozano, Patxi San Martín‐Úriz, Amaia Vilas‐Zornoza, Saray Rodríguez-Diaz, Rebeca Martínez-Turrillas, Patricia Jáuregui, Diego Alignani, María C. Viguria, Margarita Redondo, Mariona Pascal, Beatriz Martín-Antonio, Manel Juan, Álvaro Urbano‐Ispizua, Paula Rodríguez‐Otero, Ana Alfonso Piérola, Bruno Paiva, Juan José Lasarte, Susana Inogès, Ascensión López-Dı́az de Cerio, Jesús F. San Miguel, Carlos Fernández de Larrea, Mikel Hernáez, Juan R. Rodríguez-Madoz, Felipe Prósper,
Identification of new markers associated with long-term efficacy in patients treated with CAR T cells is a current medical need, particularly in diseases such as multiple myeloma. In this study, we address the impact of CAR density on the functionality of BCMA CAR T cells. Functional and transcriptional studies demonstrate that CAR T cells with high expression of the CAR construct show an increased tonic signaling with up-regulation of exhaustion markers and increased in vitro cytotoxicity but a ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2022 - American Association for the Advancement of Science | Science Advances