David Gajan, Aurélien Bornet, Basile Vuichoud, Jonas Milani, Roberto Melzi, Henri A. van Kalkeren, Laurent Veyre, Chloé Thieuleux, Matthew P. Conley, W Grüning, Martin Schwarzwälder, Anne Lesage, Christophe Copéret, Geoffrey Bodenhausen, Lyndon Emsley, Sami Jannin,
Significance Hyperpolarization by dissolution dynamic nuclear polarization can dramatically enhance signal intensities in MRI and NMR, notably for metabolic tracers for imaging and diagnosis. It is applicable to a variety of substrates for in vivo imaging and chemistry but requires the use of contaminants (glassing agents and free radicals) that may interact with cells and proteins and can have potential side effects. These contaminants can sometimes be eliminated by precipitation followed by filtration ...
Tópico(s): Electron Spin Resonance Studies
2014 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Alexandre Zagdoun, Aaron J. Rossini, Matthew P. Conley, W Grüning, Martin Schwarzwälder, Moreno Lelli, W. Trent Franks, Hartmut Oschkinat, Christophe Copéret, Lyndon Emsley, Anne Lesage,
In a spin: The use of deuterated surface passivation agents is shown to restore dynamic nuclear polarization (DNP) surface-enhanced NMR signals that are reduced in substrates containing methyl groups, while still protecting sensitive sites on the surface (see picture). Furthermore, apolar groups such as [D9]-trimethylsiloxy (TMS) repel radicals (yellow) away from the surface, thus diminishing detrimental paramagnetic effects induced by radical proximity.
Tópico(s): NMR spectroscopy and applications
2013 - Wiley | Angewandte Chemie International Edition
Alexandre Zagdoun, Aaron J. Rossini, Matthew P. Conley, W Grüning, Martin Schwarzwälder, Moreno Lelli, W. Trent Franks, Hartmut Oschkinat, Christophe Copéret, Lyndon Emsley, Anne Lesage,
Aktive Blockierung: Mit deuterierten Blockierungsreagentien werden oberflächenverstärkte DNP-NMR-Signale, die durch Methylgruppen enthaltende Substrate beeinträchtigt werden, wiederhergestellt; die Schutzgruppenfunktion auf der Oberfläche bleibt dabei erhalten (siehe Bild; DNP=dynamische Kernpolarisation). Unpolare Gruppen wie [D9]-Trimethylsiloxy (TMS) halten Radikale (gelb) von der Oberfläche fern und vermindern dadurch schädliche paramagnetische Effekte. As a service to our authors and readers, this ...
Tópico(s): Atomic and Subatomic Physics Research
2013 - Wiley | Angewandte Chemie
Dieter Weichert, A.R.S. Ponter,
... design under variable loads came into the picture. Martin Grüning was the first to be attracted by the ...
Tópico(s): Probabilistic and Robust Engineering Design
2013 - Springer International Publishing | Lecture notes in applied mathematics and mechanics
Siegfried Kropf, Holger Heuer, Martin Grüning, Kornelia Smalla,
Modern electrophoresis techniques are often applied to investigate complex microbial communities. Analysis systems like GelCompare transform the optical pattern of the electrophoresis lanes into high-dimensional observation vectors and calculate measures of difference or similarity between pairs of lanes. Usually, these measures are applied in cluster analyses. Here, we apply permutation tests for the comparison of groups of lanes based on these pairwise measures together with some extensions for ...
Tópico(s): Gene expression and cancer classification
2004 - Elsevier BV | Journal of Microbiological Methods
Clara S. R. Grüning, Stefan Klinker, Martin Wolff, Mario Schneider, Küpra Toksöz, Antonia Klein, Luitgard Nagel‐Steger, Dieter Willbold, Wolfgang Hoyer,
The interconversion of monomers, oligomers, and amyloid fibrils of the amyloid-β peptide (Aβ) has been implicated in the pathogenesis of Alzheimer disease. The determination of the kinetics of the individual association and dissociation reactions is hampered by the fact that forward and reverse reactions to/from different aggregation states occur simultaneously. Here, we report the kinetics of dissociation of Aβ monomers from protofibrils, prefibrillar high molecular weight oligomers previously shown ...
Tópico(s): Supramolecular Self-Assembly in Materials
2013 - Elsevier BV | Journal of Biological Chemistry
Thilo Grüning, Anna Gilmore, Martin McKee,
Using tobacco industry documents, we examined how and why the tobacco industry sought to influence science and scientists in Germany as a possible factor in explaining the German opposition to stricter tobacco regulation. Smoking and health research programs were organized both separately by individual tobacco companies and jointly through their German trade organization. An extensive network of scientists and scientific institutions with tobacco industry links was developed. Science was distorted ...
Tópico(s): Smoking Behavior and Cessation
2005 - American Public Health Association | American Journal of Public Health
A. Grüning, Martin Krauß, Berthold Scholtes,
Lifetime of hot-work tools is often limited by the development of crack nets as a consequence of thermal and/or mechanical fatigue loading. In this paper, the isothermal fatigue behaviour of the tool steel AISI H11 (German grade X38CrMoV 5-1) under stress controlled uniaxial tension-compression loading with zero mean stress is investigated in the temperature range between room temperature and 500 °C. Different surface conditions (polished, shot peened, hard turned) were taken into account and a small ...
Tópico(s): Metal Alloys Wear and Properties
2008 - Wiley | steel research international
Antje Krüger, Nana‐Maria Grüning, Mirjam M. C. Wamelink, Martin Kerick, Alexander Kirpy, Dimitri Parkhomchuk, Katharina Bluemlein, Michal R. Schweiger, Aleksey V. Soldatov, Hans Lehrach, Cornelis Jakobs, Markus Ralser,
Aims: A shift in primary carbon metabolism is the fastest response to oxidative stress. Induced within seconds, it precedes transcriptional regulation, and produces reducing equivalents in form of NADPH within the pentose phosphate pathway (PPP). Results: Here, we provide evidence for a regulatory signaling function of this metabolic transition in yeast. Several PPP-deficiencies caused abnormal accumulation of intermediate metabolites during the stress response. These PPP-deficient strains had strong ...
Tópico(s): Plant Stress Responses and Tolerance
2011 - Mary Ann Liebert, Inc. | Antioxidants and Redox Signaling
Stephan Nothjunge, Thomas Nührenberg, Björn Grüning, S. Doppler, Sebastian Preißl, Martin Schwaderer, Carolin Rommel, Markus Krane, Lutz Hein, Ralf Gilsbach,
Storage of chromatin in restricted nuclear space requires dense packing while ensuring DNA accessibility. Thus, different layers of chromatin organization and epigenetic control mechanisms exist. Genome-wide chromatin interaction maps revealed large interaction domains (TADs) and higher order A and B compartments, reflecting active and inactive chromatin, respectively. The mutual dependencies between chromatin organization and patterns of epigenetic marks, including DNA methylation, remain poorly ...
Tópico(s): Cancer-related gene regulation
2017 - Nature Portfolio | Nature Communications
W Grüning, Harald Bieringer, Martin Schwarzwälder, David Gajan, Aurélien Bornet, Basile Vuichoud, Jonas Milani, David Baudouin, Laurent Veyre, Anne Lesage, Sami Jannin, Geoffrey Bodenhausen, Chloé Thieuleux, Christophe Copéret,
Hyperpolarization of NMR‐active nuclei is key to gather high quality spectra of rare species and insensitive isotopes. We have recently established that silica‐based materials containing regularly distributed nitroxyl radicals connected to the silica matrix by flexible linkers can serve as promising polarization matrices for dynamic nuclear polarization (DNP). Here we investigate the influence of the linker on the efficiency of the polarization. The materials were fully characterized and exhibit ...
Tópico(s): Electron Spin Resonance Studies
2016 - Wiley | Helvetica Chimica Acta
Alfred Wiedensohler, W. Birmili, Andreas Nowak, A. Sonntag, Kay Weinhold, Maik Merkel, Birgit Wehner, Thomas Tuch, Sascha Pfeifer, Markus Fiebig, A. M. Fjäraa, Eija Asmi, Karine Sellegri, R. Depuy, H. Venzac, P. Villani, Paolo Laj, Tuula Aalto, J. A. Ogren, Erik Swietlicki, P. I. Williams, Pontus Roldin, Paul Quincey, Christoph Hüglin, R. Fierz‐Schmidhauser, Martin Gysel‐Beer, E. Weingartner, Francesco Riccobono, Sebastiao Martins Dos Santos, C. Grüning, K. Faloon, David C. S. Beddows, Roy M. Harrison, C. Monahan, S. G. Jennings, Colin O’Dowd, Angela Marinoni, Hans‐Georg Horn, Lothar Keck, Jingkun Jiang, Jacob Scheckman, Peter H. McMurry, Zhaoze Deng, Chunsheng Zhao, M. Moerman, Bas Henzing, Gerrit de Leeuw, G. Löschau, Susanne Bastian,
Abstract. Mobility particle size spectrometers often referred to as DMPS (Differential Mobility Particle Sizers) or SMPS (Scanning Mobility Particle Sizers) have found a wide range of applications in atmospheric aerosol research. However, comparability of measurements conducted world-wide is hampered by lack of generally accepted technical standards and guidelines with respect to the instrumental set-up, measurement mode, data evaluation as well as quality control. Technical standards were developed ...
Tópico(s): Air Quality and Health Impacts
2012 - Copernicus Publications | Atmospheric measurement techniques
... MechanikVolume 8, Issue 3 p. 244-245 Buchbesprechung Martin Grüning, ord. Professor an der Technischen Hochschule zu Hannover. ...
Tópico(s): Mathematics and Applications
1928 - Wiley | ZAMM ‐ Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik
Jon Ison, Kristoffer Rapacki, Hervé Ménager, Matúš Kalaš, Emil Rydza, Piotr Jaroslaw Chmura, Christian Anthon, Niall Beard, Karel Berka, Dan Bolser, Tim Booth, Anthony Bretaudeau, Jan Brezovský, Rita Casadio, Gianni Cesareni, Frederik Coppens, Michael Cornell, Gianmauro Cuccuru, Kristian Davidsen, Gianluca Della Vedova, Tunca Doğan, Olivia Doppelt‐Azeroual, Laura R. Emery, Elisabeth Gasteiger, Thomas Gatter, Tatyana Goldberg, Marie Grosjean, Björn Grüning, Manuela Helmer‐Citterich, Hans Ienasescu, Vassilios Ioannidis, Martin Closter Jespersen, Rafael C. Jiménez, Nick Juty, Peter Juvan, M. H. J. Koch, Camille Laibe, Jing‐Woei Li, Luana Licata, Fabien Mareuil, Ivan Mičetić, Rune Møllegaard Friborg, Sébastien Moretti, Chris Morris, Steffen Möller, Aleksandra Nenadić, Hedi Peterson, Giuseppe Profiti, Peter Rice, Paolo Romano, Paola Roncaglia, Rabie Saidi, Andrea Schafferhans, Veit Schwämmle, Callum Smith, Maria Maddalena Sperotto, Heinz Stockinger, Radka Svobodová Vařeková, Silvio C. E. Tosatto, Victor de la Torre, Paolo Uva, Allegra Via, Guy Yachdav, Federico Zambelli, Gert Vriend, Burkhard Rost, Helen Parkinson, Peter Løngreen, Søren Brunak,
Life sciences are yielding huge data sets that underpin scientific discoveries fundamental to improvement in human health, agriculture and the environment. In support of these discoveries, a plethora of databases and tools are deployed, in technically complex and diverse implementations, across a spectrum of scientific disciplines. The corpus of documentation of these resources is fragmented across the Web, with much redundancy, and has lacked a common standard of information. The outcome is that ...
Tópico(s): Cancer Genomics and Diagnostics
2015 - Oxford University Press | Nucleic Acids Research
Wolfgang Maier, Simon Bray, Marius van den Beek, Dave Bouvier, Nathan Coraor, Milad Miladi, Babita Singh, Jordi Rambla, Dannon Baker, Nathan Roach, Simon Gladman, Frederik Coppens, Darren P. Martin, Andrew Lonie, Björn Grüning, Sergei L. Kosakovsky Pond, Anton Nekrutenko,
Tópico(s): COVID-19 Digital Contact Tracing
2021 - Nature Portfolio | Nature Biotechnology
D. Hellwig, Lutz S. Freudenberg, Felix M. Mottaghy, Christiane Franzius, Thomas Krause, I. Garai, Martin Biermann, Thomas Grüning, Thomas Leitha, Martin Gotthardt,
The technical developments that have taken place in the preceding years (PET, hybrid imaging) have changed nuclear medicine. The future cooperation with radiologists will be challenging as well as positioning nuclear medicine in an European context. It can also be expected that education in nuclear medicine will undergo a harmonization process in the states of the European Union. In this paper, we describe how nuclear medicine education is organized in several European countries. We aim to stimulate ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2012 - Schattauer Verlag | Nuklearmedizin - NuclearMedicine
Joanna Segal, Michael Mülleder, Antje Krüger, Thure Adler, Manuela Scholze‐Wittler, Lore Becker, Julia Calzada‐Wack, Lillian Garrett, Sabine M. Hölter, Birgit Rathkolb, Jan Rozman, Ildikó Rácz, R. Fischer, Dirk H. Busch, Frauke Neff, Martin Klingenspor, Thomas Klopstock, Nana‐Maria Grüning, Steve Michel, Beata Lukaszewska‐McGreal, Ingo Voigt, Ludger Hartmann, Bernd Timmermann, Hans Lehrach, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus‐Durner, Helmut Fuchs, Martin Hrabĕ de Angelis, Heinrich Schrewe, Mariia Yuneva, Markus Ralser,
Triosephosphate isomerase (TPI) deficiency is a fatal genetic disorder characterized by hemolytic anemia and neurological dysfunction. Although the enzyme defect in TPI was discovered in the 1960s, the exact etiology of the disease is still debated. Some aspects indicate the disease could be caused by insufficient enzyme activity, whereas other observations indicate it could be a protein misfolding disease with tissue-specific differences in TPI activity. We generated a mouse model in which exchange ...
Tópico(s): Pancreatic function and diabetes
2019 - Springer Science+Business Media | Journal of Inherited Metabolic Disease
Matteo Giantomassi, Martin Stankovski, R. Shaltaf, Myrta Grüning, Fabien Bruneval, Patrick Rinke, Gian‐Marco Rignanese,
Abstract We review some recent developments in many‐body perturbation theory (MBPT) calculations that have enabled the study of interfaces and defects. Starting from the theoretical basis of MBPT, Hedin's equations are presented, leading to the GW and GW Γ approximations. We introduce the perturbative approach, that is the one most commonly used for obtaining quasiparticle (QP) energies. The practical strategy presented for dealing with the frequency dependence of the self‐energy operator is based ...
Tópico(s): Physics of Superconductivity and Magnetism
2010 - Wiley | physica status solidi (b)
Dongren Wang, Martin Ebel, Carola Schulzke, C. Grüning, S.K.S. Hazari, Dieter Rehder,
The VO2+ complexes [VOCl(ONS)] (3) and [VO(ONS)′] (4), and the VO3+ complexes [VO(OEt)(ONS)′] (5) {ONS = (R)-salicylaldehyde thiosemicarbazonate(1−) R = 5,6-C4H4 (3a) or 3-OMe (3b); (ONS)′ = (R)-salicylaldehyde[benzylmercaptothiocarbonylhydrazonate(2−)], R = H, (4a/5a) or 3-OMe (4b/5b)} have been prepared and characterised by IR, EPR, 1H-, and 51V-NMR spectroscopy. In (S)-sBuOH, 4a converts to [VO{(S)-OsBu}(ONS)′] (5c) and [VO(OH)(ONS)′] (or a condensation product thereof). Solutions of 5c show three 51V NMR signals, two ...
Tópico(s): Metal complexes synthesis and properties
2001 - Wiley | European Journal of Inorganic Chemistry
Ralf Gilsbach, Martin Schwaderer, Sebastian Preißl, Björn Grüning, David Kranzhöfer, Pedro Schneider, Thomas Nührenberg, Sonia Mulero‐Navarro, Dieter Weichenhan, Christian Braun, Martina Dreßen, Adam R. Jacobs, Harald Lahm, Torsten Doenst, Rolf Backofen, Markus Krane, Bruce D. Gelb, Lutz Hein,
Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation, and in disease remains unknown. Here, we investigate the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure. We find that prenatal development and postnatal maturation are characterized by a cooperation of active ...
Tópico(s): Cancer-related gene regulation
2018 - Nature Portfolio | Nature Communications
David Gajan, Martin Schwarzwälder, Matthew P. Conley, W Grüning, Aaron J. Rossini, Alexandre Zagdoun, Moreno Lelli, Maxim Yulikov, Gunnar Jeschke, Claire Sauvée, Olivier Ouari, Paul Tordo, Laurent Veyre, Anne Lesage, Chloé Thieuleux, Lyndon Emsley, Christophe Copéret,
Mesoporous hybrid silica-organic materials containing homogeneously distributed stable mono- or dinitroxide radicals covalently bound to the silica surface were developed as polarization matrixes for solid-state dynamic nuclear polarization (DNP) NMR experiments. For TEMPO-containing materials impregnated with water or 1,1,2,2-tetrachloroethane, enhancement factors of up to 36 were obtained at ∼100 K and 9.4 T without the need for a glass-forming additive. We show that the homogeneous radical distribution ...
Tópico(s): Electron Spin Resonance Studies
2013 - American Chemical Society | Journal of the American Chemical Society
Melanie Christine Föll, Lennart Moritz, Thomas Wollmann, Maren Nicole Stillger, Niklas Vockert, Martin Werner, Peter Bronsert, Karl Rohr, Björn Grüning, Oliver Schilling,
Mass spectrometry imaging is increasingly used in biological and translational research because it has the ability to determine the spatial distribution of hundreds of analytes in a sample. Being at the interface of proteomics/metabolomics and imaging, the acquired datasets are large and complex and often analyzed with proprietary software or in-house scripts, which hinders reproducibility. Open source software solutions that enable reproducible data analysis often require programming skills and ...
Tópico(s): Advanced Proteomics Techniques and Applications
2019 - University of Oxford | GigaScience
Sebastian Preißl, Martin Schwaderer, Alexandra Raulf, Michael Hesse, Björn Grüning, Claudia Köbele, Rolf Backofen, Bernd K. Fleischmann, Lutz Hein, Ralf Gilsbach,
Rationale: Epigenetic mechanisms are crucial for cell identity and transcriptional control. The heart consists of different cell types, including cardiac myocytes, endothelial cells, fibroblasts, and others. Therefore, cell type–specific analysis is needed to gain mechanistic insight into the regulation of gene expression in cardiac myocytes. Although cytosolic mRNA represents steady-state levels, nuclear mRNA more closely reflects transcriptional activity. To unravel epigenetic mechanisms of transcriptional ...
Tópico(s): RNA Research and Splicing
2015 - Lippincott Williams & Wilkins | Circulation Research
Chengxin Dai, Anja Füllgrabe, Julianus Pfeuffer, Elizaveta M. Solovyeva, Jingwen Deng, Pablo Moreno, Selvakumar Kamatchinathan, Deepti J Kundu, Nancy George, Silvie Fexová, Björn Grüning, Melanie Christine Föll, Johannes Griss, Marc Vaudel, Enrique Audain, Marie Locard‐Paulet, Michael Turewicz, Martin Eisenacher, Julian Uszkoreit, Tim Van Den Bossche, Veit Schwämmle, Henry Webel, Stefan Schulze, David Bouyssié, Savita Jayaram, Vinay Kumar Duggineni, Patroklos Samaras, Mathias Wilhelm, Meena Choi, Mingxun Wang, Oliver Kohlbacher, Alvis Brāzma, Irene Papatheodorou, Nuno Bandeira, Eric W. Deutsch, Juan Antonio Vizcaíno, Mingze Bai, Timo Sachsenberg, Lev I. Levitsky, Yasset Pérez‐Riverol,
The amount of public proteomics data is rapidly increasing but there is no standardized format to describe the sample metadata and their relationship with the dataset files in a way that fully supports their understanding or reanalysis. Here we propose to develop the transcriptomics data format MAGE-TAB into a standard representation for proteomics sample metadata. We implement MAGE-TAB-Proteomics in a crowdsourcing project to manually curate over 200 public datasets. We also describe tools and ...
Tópico(s): Research Data Management Practices
2021 - Nature Portfolio | Nature Communications
Simon Bray, John Chilton, Matthias Bernt, Nicola Soranzo, Marius van den Beek, Bérénice Batut, Helena Rasche, Martin Čech, Peter Cock, Björn Grüning, Anton Nekrutenko,
There are thousands of well-maintained high-quality open-source software utilities for all aspects of scientific data analysis. For more than a decade, the Galaxy Project has been providing computational infrastructure and a unified user interface for these tools to make them accessible to a wide range of researchers. To streamline the process of integrating tools and constructing workflows as much as possible, we have developed Planemo, a software development kit for tool and workflow developers ...
Tópico(s): Advanced Data Storage Technologies
2023 - Cold Spring Harbor Laboratory Press | Genome Research
Lili Zhao, Maekele Yosef, Martin Steinhart, Petra Göring, H. Hofmeister, U. Gösele, Sabine Schlecht,
... Electrochem. Soc. 1993, 140, 2836; 2bA. Birner, U. Grüning, S. Ottow, A. Schneider, F. Müller, V. Lehmann, H. Föll, U. Gösele, Phys. Status Solidi A 1998, 165, 111. 3 3aC. R. Martin, Science 1994, 266, 1961; 3bC. A. Huber, T. ...
Tópico(s): Semiconductor materials and interfaces
2005 - Wiley | Angewandte Chemie International Edition
Isabelle Dhennin‐Duthille, Rémy Nyga, Saliha Yahiaoui, Valérie Gouilleux‐Gruart, Jean-Claude Régnier, Kaı̈ss Lassoued, Fabrice Gouilleux,
... Halfter H. Matsumura I. Schmidt R. Müller C. Grüning W. Kratz-Albers K. Serve S. Steur C. Büchner T. Kienast J. Kanakura Y. Berdel W.E. Serve H. Blood. 2000; 96: 3907-3914Crossref PubMed Google Scholar, 20Harir N. Boudot C. Friedbichler K. Sonneck K. Kondo R. Martin-Lannerée S. Kenner L. Kerenyi M. Yahiaoui S. ... Halfter H. Matsumura I. Schmidt R. Müller C. Grüning W. Kratz-Albers K. Serve S. Steur C. Büchner T. Kienast J. Kanakura Y. Berdel W.E. Serve H. Blood. 2000; 96: 3907-3914Crossref PubMed Google Scholar, 20Harir N. Boudot C. Friedbichler K. Sonneck K. Kondo R. Martin-Lannerée S. Kenner L. Kerenyi M. Yahiaoui S. ...
Tópico(s): Cancer-related gene regulation
2010 - Elsevier BV | Journal of Biological Chemistry
Laura V. Glaser, Simone Rieger, Sybille Thumann, Sophie Beer, Cornelia Kuklik‐Roos, Dietmar E. Martin, Kerstin C. Maier, Marie L. Harth-Hertle, Björn Grüning, Rolf Backofen, Stefan Krebs, Helmut Blum, Ralf Zimmer, Florian Erhard, Bettina Kempkes,
Epstein-Barr virus (EBV) infection converts resting human B cells into permanently proliferating lymphoblastoid cell lines (LCLs). The Epstein-Barr virus nuclear antigen 2 (EBNA2) plays a key role in this process. It preferentially binds to B cell enhancers and establishes a specific viral and cellular gene expression program in LCLs. The cellular DNA binding factor CBF1/CSL serves as a sequence specific chromatin anchor for EBNA2. The ubiquitous expression of this highly conserved protein raises the ...
Tópico(s): Lymphoma Diagnosis and Treatment
2017 - Public Library of Science | PLoS Pathogens
Darren P. Martin, Spyros Lytras, Alexander G. Lucaci, Wolfgang Maier, Björn Grüning, Stephen D. Shank, Steven Weaver, Oscar A. MacLean, Richard Orton, Philippe Lemey, Maciej F. Boni, Houriiyah Tegally, Gordon W. Harkins, Cathrine Scheepers, Jinal N. Bhiman, Josie Everatt, Daniel G. Amoako, James Emmanuel San, Jennifer Giandhari, Alex Sigal, Carolyn Williamson, Marvin Hsiao, Anne von Gottberg, Arné de Klerk, Robert W. Shafer, David L. Robertson, Robert J. Wilkinson, B.T. Sewell, Richard Lessells, Anton Nekrutenko, Allison J. Greaney, Tyler N. Starr, Jesse D. Bloom, Ben Murrell, Eduan Wilkinson, Ravindra K. Gupta, Túlio de Oliveira, Sergei L. Kosakovsky Pond,
Among the 30 nonsynonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will likely impact (1) interactions between subunits of the Spike trimer and the predisposition of subunits to shift from down to up configurations, (2) interactions of Spike with ACE2 receptors, and (3) the priming of Spike for membrane fusion. We show here that, ...
Tópico(s): Bacteriophages and microbial interactions
2022 - Oxford University Press | Molecular Biology and Evolution
Enis Afgan, Dannon Baker, Bérénice Batut, Marius van den Beek, Dave Bouvier, Martin Čech, John Chilton, Dave Clements, Nate Coraor, Björn Grüning, Aysam Guerler, Jennifer Hillman‐Jackson, Saskia Hiltemann, Vahid Jalili, Helena Rasche, Nicola Soranzo, Jeremy Goecks, James Taylor, Anton Nekrutenko, Daniel Blankenberg,
Galaxy (homepage: https://galaxyproject.org, main public server: https://usegalaxy.org) is a web-based scientific analysis platform used by tens of thousands of scientists across the world to analyze large biomedical datasets such as those found in genomics, proteomics, metabolomics and imaging. Started in 2005, Galaxy continues to focus on three key challenges of data-driven biomedical science: making analyses accessible to all researchers, ensuring analyses are completely reproducible, and making ...
Tópico(s): Gene expression and cancer classification
2018 - Oxford University Press | Nucleic Acids Research