Takeshi Endo, Hiroyuki Fukuda, Masahiro Hirota,
... acetal and carbon disulfide through macrozwitterionTakeshi Endo, Hiroyuki Fukuda, and Masahiro HirotaCite this: J. Am. Chem. Soc. 1984, 106, ...
Tópico(s): Synthesis of heterocyclic compounds
1984 - American Chemical Society | Journal of the American Chemical Society
Masahiro Irifune, Takeo Fukuda, Masahiro Nomoto, Tomoaki Sato, Yoshiko Kamata, Takashige Nishikawa, Wataru MIETANI, Kozo Yokoyama, Kazuna Sugiyama, Michio Kawahara,
The effects of ketamine on the levels of dopamine (DA), norepinephrine (NE), 5-hydroxytryptamine (5-HT, serotonin) and their metabolites were examined in discrete brain regions in mice. A high dose of ketamine (150 mg/kg, i.p.) did not change DA metabolism in the frontal cortex, nucleus accumbens, striatum and hippocampus, but did decrease it in the brainstem during anesthesia. In contrast, during recovery from the ketamine anesthesia, the high dose increased the level of homovanillic acid (HVA) in all ...
Tópico(s): Treatment of Major Depression
1997 - Elsevier BV | Brain Research
Hiroshi Yoshida, Ikuko Fukuda, Masahiro Hashiguchi,
... Oxford Academic PubMed Google Scholar Ikuko FUKUDA, Ikuko FUKUDA Department of Chemistry, Faculty of Science, Tohoku UniversityAobayama, Sendai, Miyagi 980 Search for other works by this author on: Oxford Academic PubMed Google Scholar Masahiro HASHIGUCHI Masahiro HASHIGUCHI Department of Chemistry, Faculty of ...
Tópico(s): RNA and protein synthesis mechanisms
1980 - Oxford University Press | The Journal of Biochemistry
Michitsugu Kamezaki, Tetsuro Kusaba, Kazumi Komaki, Yohei Fushimura, Noriko Watanabe, Kisho Ikeda, Takashi Kitani, N. Yamashita, Masahiro Uehara, Yuhei Kirita, Yayoi Shiotsu, Ryosuke Sakai, Takuya Fukuda, Masahiro Yamazaki, Michiaki Fukui, Satoaki Matoba, Keiichi Tamagaki,
Abstract Clinical and experimental studies have shown that sodium glucose co-transporter 2 inhibitors (SGLT2i) contribute to the prevention of diabetic kidney disease progression. In order to clarify its pharmacological effects on the molecular mechanisms underlying the development of diabetic kidney disease, we administered different doses of the SGLT2i, ipragliflozin, to type 2 diabetic mice. A high-dose ipragliflozin treatment for 8 weeks lowered blood glucose levels and reduced urinary albumin ...
Tópico(s): Renal Diseases and Glomerulopathies
2018 - Nature Portfolio | Scientific Reports
Shunsuke Matsumoto, Yoshitake Yamada, Masahiro Hashimoto, Teppei Okamura, Minoru Yamada, Fumiaki Yashima, Kentaro Hayashida, Keiichi Fukuda, Masahiro Jinzaki,
Tópico(s): Infective Endocarditis Diagnosis and Management
2016 - Springer Science+Business Media | European Radiology
Masashi Tamura, Yoshitake Yamada, Takashi Kawakami, Masaharu Kataoka, Yu Iwabuchi, Hiroaki Sugiura, Masahiro Hashimoto, Tadaki Nakahara, Shigeo Okuda, Seishi Nakatsuka, Fumiya Sano, Takayuki Abe, Yuichiro Maekawa, Keiichi Fukuda, Masahiro Jinzaki,
Background For treatment of chronic thromboembolic pulmonary hypertension (CTEPH), the evaluation of segmental pulmonary perfusion is important. There are no previous reports about lung subtraction iodine mapping (LSIM) computed tomography (CT) for evaluation of segmental pulmonary perfusion in patients with CTEPH, using lung perfusion SPECT/CT (LPS) as the reference. Methods 50 patients (age, 60.7 ± 16.7 years) with known or suspected CTEPH were enrolled in this study. Non-contrast chest CT and CT pulmonary ...
Tópico(s): Cardiac Imaging and Diagnostics
2017 - Elsevier BV | International Journal of Cardiology
Sumio Fukuda, Masahiro Aoyama, Yasumasa Yamada, Noritatu SAITOH, Takae Honjoh, T. Hasegawa, Masahide Futamura, Junya Katoh, Norihiro Niimi, Shuichi Tanaka, Masahiro Nagaya,
Tópico(s): Mechanical Circulatory Support Devices
1999 - Springer Science+Business Media | Pediatric Surgery International
Takahiro Matsumoto, Atsuo Fukuda, Masahiro Johno, Y. Motoyama, Tomoyuki Yui, San‐Seong Seomun, Mamoru Yamashita,
We have studied the frustration between ferro- and antiferro-electricity in chiral smectic C like liquid crystalline phases, which is not only fundamentally interesting but also very attractive from an application point of view. It causes temperature induced successive phase transitions as characterized by a devil's staircase and the thresholdless, hysteresis-free, V-shaped switching induced by an applied electric field. The devil's staircase indicates some type of interlayer ordering, while the ...
Tópico(s): Material Dynamics and Properties
1999 - Royal Society of Chemistry | Journal of Materials Chemistry
Hideki Nakagawa, Hiroyuki Fukuda, Masahiro Kawaida, Akihiro Shiotani, Jin Kanzaki,
To evaluate how the viscosity of the laryngeal mucus influences vocal fold vibration, two fluids of differing viscosity were applied separately to excised canine larynges and experimental phonation was induced. Vibration of the vocal folds was measured by use of a laryngostroboscope and an X-ray stroboscope. With the high viscosity fluid, the amplitude of vibration of the free edge and the peak glottal area was decreased while the open quotient was increased. Because the viscosity of this fluid ...
Tópico(s): Speech Recognition and Synthesis
1998 - Karger Publishers | Folia Phoniatrica et Logopaedica
Ma Tao, H. Kodama, Satosi KAGABU, Junichiro Fukuda, Masahiro Murata, YOUICHI SHIMIZU, Hideto Hirano, Takao Tanaka,
The aim of this study was to investigate the relationships between follicular nitric oxide (NO) metabolite concentrations and several related variables, with special reference to follicular interleukin-1beta (IL-1beta). The follicular fluid from the leading and secondary follicles was collected individually from 20 women undergoing in-vitro fertilization (IVF) treatment, and the concentrations of nitrite (NO2-) and nitrate (NO3-) were determined fluorometrically using 2,3-diaminonaphthalene. Both follicular ...
Tópico(s): Ovarian function and disorders
1997 - Oxford University Press | Human Reproduction
Masatomi Sakamoto, Yasutaka Kitakami, Hiroshi Sakiyama, Yuzo Nishida, Yutaka Fukuda, Masahiro Sakai, Yoshihiko Sadaoka, Akira Matsumoto, Hisashi Ōkawa,
Heteronuclear copper(II)-lanthanide(III) complexes of H2(Fsal-3), CuLn(Fsal-3)(NO3)3 (CH3OH)0.5 (Ln: La, Nd, Eu, Gd or Ho), were synthesized and characterized, where H2(Fsal-3) denotes N,N′-bis(3-formyl-5-methylsalicyclidene)-1,3-propanediamine and CuII and LnIII are located at the N2O2- and O4-coordination sites of ligand, respectively. The bonding behavior of amino alcohols toward the CuLn heterochemical centre was discussed, based on the absorption spectra and circular dichroism. The fluorescence ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
1997 - Elsevier BV | Polyhedron
Masatomi Sakamoto, Takashi Ishikawa, Yuzo Nishida, Yoshihiko Sadaoka, Akira Matsumoto, Yutaka Fukuda, Masahiro Sakai, Masaaki Ohba, Hiroshi Sakiyama, Hisashi Ōkawa,
Mononuclear oxovanadium(IV) complex VO(H2dhbaen) and heteronuclear oxovanadium(IV)-lanthanide(III) complexes VOLn(dhbaen)(NO3)(H2O)2.5 were synthesized, where H4dhbaen denotes N,N′-bis(3-hydroxysalicylidene)ethylenediamine. IR spectra showed that V(IV)O and Ln(III) ions are located at the endogenous N2O2- and the exogeneous O4-coordination sites of the ligand respectively. Based on circular dichroism (CD) spectra, it was suggested that amino alcohols are specifically bound at the VO-Ln heterometal ...
Tópico(s): Magnetism in coordination complexes
1996 - Elsevier BV | Journal of Alloys and Compounds
Seiji Matsuda, Hui Peng, Hiroyuki Yoshimura, Tong‐Chun Wen, Tamotsu Fukuda, Masahiro Sakanaka,
Tópico(s): Pain Mechanisms and Treatments
1996 - Elsevier BV | Neuroscience Research
Takeshi Yamashina, Daiki Nemoto, Yoshikazu Hayashi, Hisashi Fukuda, Masahiro Okada, Takahito Takezawa, Masato Aizawa, Hirotsugu Sakamoto, Yoshimasa Mıura, Keijiro Sunada, Alan Kawarai Lefor, Kazutomo Togashi, Hironori Yamamoto,
Background and Aims Colorectal endoscopic submucosal dissection (ESD) is recognized as a challenging procedure. Previously, we reported that a new ESD strategy using the pocket-creation method (PCM) is useful for colorectal ESD, but no prospective randomized study has evaluated the efficacy of the PCM. The aim of this study was to evaluate the efficacy and safety of PCM for colorectal ESD compared with the conventional method (CM). Methods This was a prospective randomized controlled trial at 3 institutions ...
Tópico(s): Metastasis and carcinoma case studies
2020 - Elsevier BV | Gastrointestinal Endoscopy
Yoko Sato, Masayuki Ishihara, Shingo Nakamura, Koichi Fukuda, Masahiro Kuwabara, T. Takayama, Sumiyo Hiruma, Kaoru Murakami, Masanori Fujita, Hidetaka Yokoe,
The bactericidal activity of heated bio-shell calcium oxide (BiSCaO) powder suspension (pH 12.4) , hypochlorous acid (HClO; pH 6), sodium hypochlorite (NaClO; pH 8) , povidone-iodine (Isodine solution®) , and chlorhexidine gluconate (Hibiscrub®) under organic matter contaminated environments were compared for tests conducted on wood scraps and pig skin pieces that were incubated with normal bacterial flora (total viable counts and coliform bacteria) . The test results showed that BiSCaO suspension had higher bactericidal ...
Tópico(s): Antimicrobial agents and applications
2019 - | Biocontrol Science
Nozomi Takagi, Kazuya Ishimura, Hiroki Miura, Tetsuya Shishido, Ryoichi Fukuda, Masahiro Ehara, Shigeyoshi Sakaki,
Density functional theory calculations here elucidated that Cu38-catalyzed NO reduction by CO occurred not through NO dissociative adsorption but through NO dimerization. NO is adsorbed to two Cu atoms in a bridging manner. NO adsorption energy is much larger than that of CO. N-O bond cleavage of the adsorbed NO molecule needs a very large activation energy (ΔG°‡). On the other hand, dimerization of two NO molecules occurs on the Cu38 surface with small ΔG°‡ and very negative Gibbs reaction energy ( ...
Tópico(s): Catalysis and Oxidation Reactions
2019 - American Chemical Society | ACS Omega
Nozomi Takagi, Kazuya Ishimura, Ryoichi Fukuda, Masahiro Ehara, Shigeyoshi Sakaki,
Reaction of NO molecule on M13 and M55 clusters (M = Ru, Rh, Pd, and Ag) was theoretically investigated to elucidate why its reaction behavior depends on the position of metal element in the periodic table. DFT computations show that NO dissociative adsorption occurs on M = Ru and Rh, NO molecular adsorption occurs on M = Pd, and NO dimerization occurs on M = Ag, which agree with experimental findings. The d-band center and d-band top become lower in energy following the order Ru > Rh > Pd > Ag; this is one of ...
Tópico(s): nanoparticles nucleation surface interactions
2019 - American Chemical Society | The Journal of Physical Chemistry A
Yutaka Kondo, Toru Hifumi, Junya Shimazaki, Yasutaka Oda, Shin‐ichiro Shiraishi, Kei Hayashida, Tatsuma Fukuda, Masahiro Wakasugi, Jun Kanda, Takashi Moriya, Masaharu Yagi, Takashi Kawahara, Michihiko Tonouchi, Shoji Yokobori, Hiroyuki Yokota, Yasufumi Miyake, Keiki Shimizu,
Background: This study aims to compare the Bouchama heatstroke (B-HS) and Japanese Association for Acute Medicine heatstroke (JAAM-HS) criteria with regard to the diagnosis and prediction of mortality and neurological status of heatstroke patients. Methods: This multicenter observational study recruited eligible patients from the emergency departments of 110 major hospitals in Japan from 1 July to 30 September, 2014. Results: A total of 317 patients (median age, 65 years; interquartile range, 39–80 ...
Tópico(s): Thermal Regulation in Medicine
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Takafumi Osaka, Yoshitaka Hashimoto, Takuro Okamura, Takuya Fukuda, Masahiro Yamazaki, Masahide Hamaguchi, Michiaki Fukui,
Body weight reduction leads to improvement of nonalcoholic fatty liver disease (NAFLD), but the contributions of body composition modification on its improvement have not been clarified yet. We performed a retrospective cohort study in a Japanese university hospital to clarify the effect of body fat reduction on the improvement of hepatic stiffness as well as hepatic steatosis. The skeletal muscle mass index (SMI, kg/m2), fat to muscle mass ratio, and the change in fat to muscle mass ratio after 1 ...
Tópico(s): Diet and metabolism studies
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Shimpei Anami, Hiroshi Doi, Kiyoshi Nakamatsu, Takuya Uehara, Yutaro Wada, Kohei Fukuda, Masahiro Inada, Kazuki Ishikawa, Shuichi Kanamori, Yasumasa Nishimura,
This study aimed to identify factors that predict prognosis after radiotherapy for brain metastases (BMs) from small-cell lung cancer (SCLC). This study retrospectively evaluated 48 consecutive patients who underwent whole-brain radiotherapy (WBRT) for BMs from SCLC between February 2008 and December 2017. WBRT was delivered at a median dose of 30 Gy (range: 30-40 Gy) in 10 fractions (range: 10-16 fractions). Clinical factors were tested for associations with overall survival after WBRT. The median survival ...
Tópico(s): Neuroendocrine Tumor Research Advances
2018 - Oxford University Press | Journal of Radiation Research
Masahiro Fukuda, Kunihiro Doi, Masahiro Sugawara, Koichi Mochizuki,
To investigate the efficacy and safety of sitagliptin in elderly patients with type 2 diabetes mellitus, with a focus on hypoglycemia.Type 2 diabetes mellitus patients who started sitagliptin therapy and were followed for 52 weeks were enrolled in the Impact of Sitagliptin on Diabetes Mellitus in Japanese Elderly Patients study. The frequency of hypoglycemia and knowledge of hypoglycemia were analyzed using a questionnaire.In total, 5,130 patients (aged 73.8 ± 6.1 years) were analyzed. A significant ...
Tópico(s): Pharmacology and Obesity Treatment
2018 - Asian Association for the Study of Diabetes | Journal of Diabetes Investigation
Hiroshi Doi, Kiyoshi Nakamatsu, Shimpei Anami, Kohei Fukuda, Masahiro Inada, Hitoshi Tatebe, Kazuki Ishikawa, Shuichi Kanamori, Hajime Monzen, Yasumasa Nishimura,
This study aimed to identify prognostic factors for response to whole-brain radiotherapy (WBRT) in patients with brain metastases (BMs) from non-small cell lung cancer (NSCLC).This study retrospectively evaluated 100 patients who underwent WBRT for BMs from NSCLC between December 2012 and October 2017. Clinical factors were tested for associations with overall survival after WBRT.The median follow-up time was 134 days (range=14-1,395 days), the median survival time was 143 days, and the 1-year survival ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2018 - Stanford University Highwire Press | In Vivo
Koji Takagi, Yoshihiro Yamada, Ryoichi Fukuda, Masahiro Ehara, Daisuke Takeuchi,
Double intramolecular hydrogen bonding enables efficient ESIPT emission both in solution and solid states.
Tópico(s): Organic Light-Emitting Diodes Research
2018 - Royal Society of Chemistry | New Journal of Chemistry
Akihito Ochiai, Kodai Ogawa, Minami Fukuda, Masahiro Ohori, Takumi Kanaoka, Takaaki Tanaka, Masayuki Taniguchi, Yoshiyuki Sagehashi,
Fungal infections, such as candidiasis and aspergillosis, are some of the most frequent infections in humans. Although antifungal drugs are available for the treatment of these infections, antifungal agents with new mechanisms of action should be developed because of the increasing incidence of drug-resistant pathogens in recent years. In this study, a basic functional analysis of rice defensin OsAFP1, a novel antifungal drug candidate, was conducted. OsAFP1 exerted fungicidal activity against Candida ...
Tópico(s): Invertebrate Immune Response Mechanisms
2018 - Nature Portfolio | Scientific Reports
Koji Takagi, Kaede Ito, Yoshihiro Yamada, Takuya Nakashima, Ryoichi Fukuda, Masahiro Ehara, Hyuma Masu,
Two excited-state intramolecular proton transfer (ESIPT) active benzimidazole derivatives (1 and 2) were synthesized by acid-catalyzed intramolecular cyclization. The steady-state fluorescence spectrum in THF revealed that ring-fused derivative 1 exhibits a dual emission, namely, the major emission was from the K* (keto) form (ESIPT emission) at 515 nm with a large Stokes shift of 11 100 cm-1 and the minor emission was from the E* (enol) form at below 400 nm. In contrast, the normal emission from the ...
Tópico(s): Organic Light-Emitting Diodes Research
2017 - American Chemical Society | The Journal of Organic Chemistry
Reiko Tasaka, Takeshi Fukuda, Masahiro Shimomura, Yuta Inoue, Takuma Wada, Masaru Kawanishi, Tomoyo Yasui, Toshiyuki Sumi,
The standard treatment for ovarian serous carcinoma comprises maximum debulking surgery and platinum-based chemotherapy. Despite the high response rate to chemotherapy, the majority of patients will be resistant to first‑line agents and the prognosis for these patients is particularly poor. At present there are no reliable methods to determine or predict platinum resistance. T‑box 2 (TBX2) is widely expressed in cancer cells and is involved in embryonic development and cell cycle regulation. TBX2 ...
Tópico(s): Genomics and Chromatin Dynamics
2017 - Spandidos Publishing | Oncology Letters
Hajime Fukuda, Masahiro Ibe, Motoo Suzuki, Tsutomu T. Yanagida,
The Peccei-Quinn (PQ) solution to the strong $CP$ problem requires an anomalous global $U(1)$ symmetry, the PQ symmetry. The origin of such a convenient global symmetry is quite puzzling from the theoretical point of view in many aspects. In this paper, we propose a simple prescription which provides an origin of the PQ symmetry. There, the global $U(1)$ PQ symmetry is virtually embedded in a gauged $U(1)$ PQ symmetry. Due to its simplicity, this mechanism can be implemented in many conventional models ...
Tópico(s): Noncommutative and Quantum Gravity Theories
2017 - Elsevier BV | Physics Letters B
Nozomi Takagi, Kazuya Ishimura, Masafuyu Matsui, Ryoichi Fukuda, Masahiro Ehara, Shigeyoshi Sakaki,
DFT calculations of binary transition-metal nanoclusters Cu38–nMn (M = Ru, Rh, Pd, Ag, Os, Ir, Pt, and Au; n = 1, 2, and 6) clearly show that a core–shell structure Cu32M6(core) with M in the core is stable for M = Ru, Rh, Os, and Ir but unstable for M = Pd, Ag, Pt, and Au. These results are consistent with the segregation energies evaluated for Cu37M. Electron population is more accumulated on the core M atoms in Cu38–nMn(core) (M = Ru, Rh, Os, and Ir) than on the core Cu atoms in Cu38. Such electron accumulation ...
Tópico(s): Advanced Chemical Physics Studies
2017 - American Chemical Society | The Journal of Physical Chemistry C
Tomoyuki Abe, Hironobu Amano, Keiji Hanada, Tomoyuki Minami, Shuji Yonehara, Minoru Hattori, Tsuyoshi Kobayashi, Toshikatsu Fukuda, Masahiro Nakahara, Hideki Ohdan, Toshio Noriyuki,
Background/Aim: Perioperative red blood cell transfusion (RBCT) can negatively affect the host9s immune system. We investigated the effects of perioperative RBCT on long-term survival among patients with pancreatic ductal adenocarcinoma (PDAC). Patients and Methods: We retrospectively evaluated 148 patients with PDAC who underwent surgery with curative intent (33 who received RBCTs and 115 who did not). Significant prognostic variables on univariate analysis were subjected to multivariate analyses ...
Tópico(s): Hyperglycemia and glycemic control in critically ill and hospitalized patients
2017 - International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts | Anticancer Research
Hirotsugu Sakamoto, Yoshikazu Hayashi, Yoshimasa Mıura, Satoshi Shinozaki, Haruo Takahashi, Hisashi Fukuda, Masahiro Okada, Yuji Ino, Takahito Takezawa, Keijiro Sunada, Alan Kawarai Lefor, Hironori Yamamoto,
Abstract Background and study aims The pocket-creation method (PCM) is a novel strategy for endoscopic submucosal dissection (ESD). The aim of this study is to determine the efficacy of the PCM for colorectal laterally spreading tumors, non-granular type (LST-NG). Patients and methods The records of 126 consecutive patients with colorectal LST-NG who underwent ESD between April 2012 and July 2015 were retrospectively reviewed. Patients were divided into PCM (n = 73) and conventional method (CM) (n = 53) groups. ...
Tópico(s): Metastasis and carcinoma case studies
2017 - Thieme Medical Publishers (Germany) | Endoscopy International Open