Chizu Tanikawa, Yaozhong Zhang, Ryuta Yamamoto, Yusuke Tsuda, Masami Tanaka, Yuki Funauchi, Jinichi Mori, Seiya Imoto, Rui Yamaguchi, Yusuke Nakamura, Satoru Miyano, Hidewaki Nakagawa, Koichi Matsuda,
Although recent cancer genomics studies have identified a large number of genes that were mutated in human cancers, p53 remains as the most frequently mutated gene. To further elucidate the p53-signalling network, we performed transcriptome analysis on 24 tissues in p53+/+ or p53-/- mice after whole-body X-ray irradiation. Here we found transactivation of a total of 3551 genes in one or more of the 24 tissues only in p53+/+ mice, while 2576 genes were downregulated. p53 mRNA expression level in ...
Tópico(s): Epigenetics and DNA Methylation
2017 - Elsevier BV | EBioMedicine
Ngoc Han Tu, Yoichi Tanabe, Khuong Kim Huynh, Yohei Sato, Hidetoshi Oguro, Satoshi Heguri, Kenji Tsuda, Masami Terauchi, Kazuo Watanabe, Katsumi Tanigaki,
We report the growth of high quality Bi2−xSbxTe3−ySey ultrathin nanoplates (BSTS-NPs) on an electrically insulating fluorophlogopite mica substrate using a catalyst-free vapor solid method. Under an optimized pressure and suitable Ar gas flow rate, we control the thickness, the size, and the composition of the BSTS-NPs. Raman spectra showing systematic change indicate that the thicknesses and compositions of the BSTS-NPs are indeed accurately controlled. Electrical transport demonstrates a robust ...
Tópico(s): 2D Materials and Applications
2014 - American Institute of Physics | Applied Physics Letters
Yutaro Tsuda, Masami Kuriyama, Osamu Onomura,
Chiral oxazolines: A synthetic method to prepare optically active oxazolines through a copper-catalyzed asymmetric desymmetrization of 1,3-diols has been successfully developed. This reaction system tolerated a diverse range of substrates to give the desired oxazoline derivatives in good to excellent yields with high enantioselectivities (see scheme). Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited ...
Tópico(s): Catalytic C–H Functionalization Methods
2012 - Wiley | Chemistry - A European Journal
Tomomi Tsuda, Masami Yamaguchi, C. Honda, Takaya Moriguchi,
We used RNA blot analysis to examine the expression of six genes of the anthocyanin biosynthesis pathway in the flowers and fruit skins at three developmental stages of white and red peaches and a deep-red nectarine [ Prunus persica (L.) Batch]. In the red peach `Akatsuki' and the deep-red nectarine `Flavortop', expression levels of anthocyanin biosynthesis genes were related to anthocyanin accumulation in the fruit skin; expression of all six genes dramatically increased at Stage III of fruit development, ...
Tópico(s): Phytochemicals and Antioxidant Activities
2004 - American Society for Horticultural Science | Journal of the American Society for Horticultural Science
Seizo Masuda, Keiji Minagawa, Masanori Tsuda, Masami Tanaka,
A large amount of heat was generated by mixing concentrated acrylic acid and concentrated 4-vinylpyridine, which led to carbonized products. When they were mixed within the limited concentration range, however, the polymerization took place spontaneously, and gave the alternating copolymer a relatively low molecular weight. The copolymerization was accelerated by a cationic catalyst, and inhibited by butylamine although it was not accelerated by a radical initiator and was not inhibited by a radical ...
Tópico(s): Polymer Science and PVC
2001 - Elsevier BV | European Polymer Journal
Yasuo MORIMOTO, Tohru Tsuda, Masami Hirohashi, Hiroshi Yamato, Hajime Hori, Akira Ohgami, Kazuhiro Yatera, Heungnam Kim, Li Ding, Masamitsu Kido, Toshiaki HIGASHI, Isamu Tanaka,
To determine which parameters are useful for the risk assessment of man-made mineral fibers (MMMFs), we examined the gene expression of interleukin-1α (IL-1α), tumor necrosis factor α (TNFα), interleukin-6 (IL-6) and inducible nitric-oxide synthase (iNOS) in mineral fiber-exposed alveolar macrophages (AMs). Male Wistar rats were intratracheally exposed to saline or mineral fibers suspended in saline (2mg of crocidolite, chrysotile, alumina silicate refractory fiber (RF1) or potassium octatitanate whisker ( ...
Tópico(s): Mesenchymal stem cell research
1999 - National Institute of Occupational Safety and Health | Industrial Health
Jun Kobayashi, Masataka Tsuda, Masami Ishibashi,
Abstract
Tópico(s): Protein Hydrolysis and Bioactive Peptides
1999 - International Union of Pure and Applied Chemistry | Pure and Applied Chemistry
Hiroshi Tsuda, Masami Kawabata, Osamu Nakamoto, Kenji Yamamoto,
This study was conducted to examine the correlation between uterine vascularity and natural history of uterine leiomyoma. Seventy women with leiomyoma participated in this study. Measurements of uterine and leiomyoma volume, as well as blood flow characteristics of the main uterine artery and leiomyoma arteries, were made every 3 months for 1 year. Leiomyoma arteries could be detected in 52 (51.5%) of 101 leiomyomas. Leiomyoma volume increased in 24 (46.2%) of 52 leiomyomas with leiomyoma artery. ...
Tópico(s): Uterine Myomas and Treatments
1998 - Wiley | Journal of Ultrasound in Medicine
Hiroshi Tsuda, Masami Kawabata, Kazume Kawabata, Kumio Yamamoto, Naohiko Umesaki,
Abstract Transvaginal ultrasonography (TVS) is considered useful for identifying endometrial malignancies, but it has a low specificity and a high false-positive rate. The purpose of this study was to improve the specificity of this technique. A total of 300 postmenopausal women were studied. They were clinically evaluated by TVS and endometrial histology. Twenty women yielded pathologic findings on endometrial examination. The mean endometrial thickness was related to the length of time since menopause. ...
Tópico(s): Endometrial and Cervical Cancer Treatments
1997 - Elsevier BV | Gynecologic Oncology
Hiroshi Tsuda, Masami Kawabata, Kumio Yamamoto, Takeshi Inoue, Naohiko Umesaki,
We compared transvaginal ultrasonography (TVS) and endometrial cytology by the Endocyte method for endometrial cancer screening. A total of 600 postmenopausal women who hoped for endometrial cancer screening (mean age, 61.1 ± 8.8 years; range, 44–87 years) underwent TVS, endometrial cytology (Endocyte method), and endometrial histology. The endometrial borders could be visualized by TVS in all women studied. However, cytology could not be performed in 59 women (9.8%) due to cervical stenosis. These 59 ...
Tópico(s): Ovarian cancer diagnosis and treatment
1997 - Elsevier BV | Gynecologic Oncology
K. Tsuno, T. Kaneyama, T. Honda, Kenji Tsuda, Masami Terauchi, Michiyoshi Tanaka,
Tópico(s): Electrical Fault Detection and Protection
1997 - Oxford University Press | Journal of Electron Microscopy
Hiroshi Tsuda, Masami Kawabata, Kazume Kawabata, Kumio Yamamoto, A Hidaka, Naohiko Umesake, Sachio Ogita,
The findings of this study suggest that the mean endometrial thickness and the cutoff thickness for detection of endometrial cancer in Occidental and Oriental postmenopausal women may differ.
Tópico(s): Gynecological conditions and treatments
1995 - Elsevier BV | American Journal of Obstetrics and Gynecology
Hiroshi Tsuda, Masami Kawabata, Kazume Kawabata, Kumio Yamamoto, A Hidaka, Naohiko Umesaki,
Transvaginal ultrasound (TVS) is generally considered superior to transabdominal ultrasound (TAS) in the estimation of endometrial abnormalities. A disadvantage of TVS is the limited field of view. The purpose of this study is a comparison between TAS and TVS for endometrial cancer screening. Ninety-one postmenopausal women were included. They were evaluated by TAS, TVS, and endometrial tissue sampling. The mean endometrial thickness estimated by TVS was larger than that obtained by TAS (p < 0.0001). ...
Tópico(s): Ovarian cancer diagnosis and treatment
1995 - Karger Publishers | Gynecologic and Obstetric Investigation
Hiroyuki Emoto, Masatoshi Tanaka, Chihiro Koga, Hideyasu Yokoo, Akira Tsuda, Masami Yoshida,
The effect of corticotropin-releasing factor (CRF) on central noradrenaline (NA) metabolism was examined by measuring levels of the major metabolite of NA, 3-methoxy-4-hydroxy-phenylethyleneglycol sulfate (MHPG-SO4) in several rat brain regions. Various doses of CRF ranging from 0.5 – 10 μg injected ICV significantly increased MHPG-SO4 levels in several brain regions including the hypothalamus, amygdala, midbrain, locus coeruleus (LC) region, and pons + medulla oblongata excluding the LC region. Plasma ...
Tópico(s): Tryptophan and brain disorders
1993 - Elsevier BV | Pharmacology Biochemistry and Behavior
Michiyoshi Tanaka, Kenji Tsuda, Masami Terauchi, Akira Fujiwara, A.‐P. Tsai, Akihisa Inoue, T. Masumoto,
Decagonal quasicrystals of Al70Ni10+xFe20−x(0 ≤ x ≤ 10) were investigated by convergent-beam electron diffraction (CBED) and transmission electron microscopy (TEM). It was revealed by the CBED method that the alloys with 0 ≤ x ≤ 7 belong to the space group of the noncentrosymmetric P10m2 and those with 7 < x ≤ 10 to the centrosymmetric P10/mmm. High resolution electron microscope images detected the existence of a specific pentagonal atom cluster in all the alloys investigated. Dark-field microscopy disclosed ...
Tópico(s): X-ray Diffraction in Crystallography
1993 - Elsevier BV | Journal of Non-Crystalline Solids
Masashi Tsuda, Hideyuki Shigemori, Masami Ishibashi, Jun’ichi Kobayashi,
... Alkaloids from the Okinawan Marine Sponge Psammaplysilla pureaMasashi Tsuda, Hideyuki Shigemori, Masami Ishibashi, and Jun'ichi KobayashiCite this: J. Nat. ...
Tópico(s): Synthesis and Biological Activity
1992 - American Chemical Society | Journal of Natural Products
Masashi Tsuda, Hideyuki Shigemori, Masami Ishibashi, Takuma Sasaki, Jun’ichi Kobayashi,
... sesterterpenes from the Okinawan marine sponge Luffariella spMasashi Tsuda, Hideyuki Shigemori, Masami Ishibashi, Takuma Sasaki, and Junichi KobayashiCite this: J. ...
Tópico(s): Organic Chemistry Synthesis Methods
1992 - American Chemical Society | The Journal of Organic Chemistry
Etsuko Tsuda, Masami Imakita, Toshikatsu Yagihara, Yasuo Ono, Shigeyuki Echigo, Osahiro Takahashi, Tetsuro Kamiya,
Tópico(s): Cardiac Structural Anomalies and Repair
1992 - Elsevier BV | American Heart Journal
Jun’ichi Kobayashi, MASASHI TSUDA, Masami Ishibashi, Hideyuki Shigemori, Terufumi Yamasu, Hiroshi Hirota, Takuma Sasaki,
To evaluate pharmacokinetics and clinical efficacy of flomoxef (6315-S, FMOX) in neonates, FMOX was administered to 21 neonates. With 20 mg/kg and 40 mg/kg of intravenous drip-infusion of FMOX 60 minutes, half lives (T 1/2's) was 64.9 minutes and 130.3 minutes, respectively, and when 20 mg/kg of FMOX was infused intravenously to 2 cases, half lives were 70.8 minutes and 110.1 minutes, respectively. When 45-100 mg/kg of FMOX was administered to 17 neonates with infections (pneumonia 8, sepsis 1, sepsis ...
Tópico(s): Neonatal Respiratory Health Research
1991 - Springer Nature | The Journal of Antibiotics
Masashi Tsuda, Masami Ishibashi, Kaori Agemi, Takuma Sasaki, Jun’ichi Kobayashi,
Six new antineoplastic isomalabaricane-type triterpenes, stelliferins A–F, have been isolated from the Okinawan marine sponge Jaspis stellifera. The structures were established by spectroscopic analyses, espesially 1D and 2D NMR techniques. The stereostructures have been elucidated by NOESY spectra as well as chemical degradation experiments.
Tópico(s): Chemical synthesis and alkaloids
1991 - Elsevier BV | Tetrahedron
Hiroshi Kaneyuki, Hideyasu Yokoo, Akira Tsuda, Masami Yoshida, Yasushi Mizuki, Michio Yamada, Masatoshi Tanaka,
The effects of psychological stress on catecholamine and indoleamine metabolism were examined in various brain regions of rats. Psychologically stressed rats were exposed to emotional responses of foot-shocked rats, but were themselves prevented from receiving foot-shock. Psychological stress for 30 min resulted in significant increases of both 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels in the medial prefrontal cortex (MPFC), but not in other dopamine (DA) terminal fields. ...
Tópico(s): Stress Responses and Cortisol
1991 - Elsevier BV | Brain Research
Jun’ichi Kobayashi, Masashi Tsuda, Asako Tanabe, Masami Ishibashi, Jie‐Fei Cheng, Shosuke Yamamura, Takuma Sasaki,
... Okinawan Marine Tunicate Cystodytes dellechiajeiJun'ichi Kobayashi, Masashi Tsuda, Asako Tanabe, Masami Ishibashi, Jie-Fei Cheng, Shosuke Yamamura, and Takuma ...
Tópico(s): Marine Biology and Environmental Chemistry
1991 - American Chemical Society | Journal of Natural Products
Masaaki Iigo, Hiroyuki Tsuda, Masami Moriyama,
Tópico(s): NF-κB Signaling Pathways
1994 - Springer Science+Business Media | Clinical & Experimental Metastasis
Koh Saitoh, Kenji Tsuda, Masami Terauchi, Michiyoshi Tanaka,
23 sets of space groups remain indistinguishable by the convergent-beam electron diffraction (CBED) method. Recently, Tsuda, Saitoh, Terauchi, Tanaka & Goodman [Acta Cryst. (2000), A56, 359-369] demonstrated that the coherent CBED method can distinguish two space-group pairs (I23, I2(1)3) and (I222, I2(1)2(1)2(1)) by observing the relative arrangements of 2-fold-rotation and 2(1)-screw axes. The other ten space-group sets, which are composed of principal rotation and screw axes and other 2-fold-rotation ...
Tópico(s): Crystallography and Radiation Phenomena
2001 - Wiley | Acta Crystallographica Section A Foundations of Crystallography
Kosuke Yamamoto, Yutaro Tsuda, Masami Kuriyama, Yosuke Demizu, Osamu Onomura,
A copper-catalyzed enantioselective transformation of tris(hydroxymethyl)aminomethane-derived aminotriols was developed to provide multisubstituted oxazolines with a tetrasubstituted carbon center. The present transformation consisted of sequential reactions involving mono-sulfonylation of aminotriols, subsequent intramolecular cyclization to afford prochiral oxazoline diols, and sulfonylative asymmetric desymmetrization of resultant oxazoline diols. In addition, the kinetic resolution process would ...
Tópico(s): Synthesis and Catalytic Reactions
2020 - Wiley | Chemistry - An Asian Journal
Kohei Kishida, Masami Tsuda, Polly Waite, Cathy Creswell, Shin‐ichi Ishikawa,
The widespread impacts of COVID-19 have affected both child and parent mental health worldwide. This study aimed to investigate the relationship between school closures due to COVID-19 and child and parent mental health in Japan. A sample of 1,984 Japanese parents with children and adolescents aged 6–15 years participated. The parents responded to online questionnaires about their own mental health and that of their children cross-sectionally. Participants were divided into three school situations ...
Tópico(s): Maternal Mental Health During Pregnancy and Postpartum
2021 - Elsevier BV | Psychiatry Research
Masatoshi Tanaka, Akira Tsuda, Hideyasu Yokoo, Masami Yoshida, Yoshishige Ida, Hiroshi Nishimura,
... for more papers by this authorAKIRA TSUDA, AKIRA TSUDA Departments of PharmacologySearch for more papers by this authorHIDEYASU YOKOO, HIDEYASU YOKOO Departments of PharmacologySearch for more papers by this authorMASAMI YOSHIDA, MASAMI YOSHIDA Departments of PharmacologySearch for more papers by ... for more papers by this authorAKIRA TSUDA, AKIRA TSUDA Departments of PharmacologySearch for more papers by this authorHIDEYASU YOKOO, HIDEYASU YOKOO Departments of PharmacologySearch for more papers by this authorMASAMI YOSHIDA, MASAMI YOSHIDA Departments of PharmacologySearch for more papers by ...
Tópico(s): Stress Responses and Cortisol
1990 - Wiley | Annals of the New York Academy of Sciences
Hiroshi Tsuda, Masami Kawabata, Kumio Yamamoto, Takeshi Inoue, Naohiko Umesaki,
Tópico(s): Cervical Cancer and HPV Research
1998 - Elsevier BV | Gynecologic Oncology
Hiroshi Tsuda, Masami Kawabata, Kumio Yamamoto, Naohiko Umesaki,
... Gynaecology, Osaka City General Hospital, JapanCorrespondence: Dr H. Tsuda, Department of Obstetrics and Gynaecology, Osaka City General Hospital, 2-13-22 Miyakojimahondori, Miyakojima, Osaka, Japan.Search for more papers by this authorMasami Kawabata, Masami Kawabata MD, PhD Departments of Obstetrics and Gynaecology, ... Gynaecology, Osaka City General Hospital, JapanCorrespondence: Dr H. Tsuda, Department of Obstetrics and Gynaecology, Osaka City General Hospital, 2-13-22 Miyakojimahondori, Miyakojima, Osaka, Japan.Search for more papers by this authorMasami Kawabata, Masami Kawabata MD, PhD Departments of Obstetrics and Gynaecology, ...
Tópico(s): Ultrasound Imaging and Elastography
1996 - Wiley | BJOG An International Journal of Obstetrics & Gynaecology
H.-N. Kim, Yasuo Morimoto, Tohru Tsuda, Yuko Ootsuyama, Masami Hirohashi, Tatsuya Hirano, Isamu Tanaka, Yejee Lim, Im Goung Yun, Hiroshi Kasai,
We examined 8-hydroxyguanine (8-OH-Gua) formation and 8-OH-Gua repair enzyme activity in pulmonary type-II-like epithelial cells to determine whether oxidative stress induced by asbestos plays a role in its carcinogenic mechanism. A549 cells were incubated with crocidolite asbestos at concentrations of 0, 10, 50 and 100 microg/ml over 27 h. We then evaluated 8-OH-Gua formation, 8-OH-Gua repair enzyme activity and gene expression of 8-oxoguanine-DNA glycosylase 1 (hOGG1) and human MUtT homologue (hMTH1). ...
Tópico(s): Acute Lymphoblastic Leukemia research
2001 - Oxford University Press | Carcinogenesis