Rie Tanaka, Shigeru Sanada, Masayuki Suzuki, Takeshi Kobayashi, Takeshi Matsui, Hitoshi Inoue, Yoshihisa Nakano,
... JapanSearch for more papers by this authorMasayuki Suzuki, Masayuki Suzuki Department of Radiological Technology, School of Health Sciences, ... JapanSearch for more papers by this authorMasayuki Suzuki, Masayuki Suzuki Department of Radiological Technology, School of Health Sciences, ...
Tópico(s): Pleural and Pulmonary Diseases
2004 - Wiley | Medical Physics
Takehisa Ishii, Maki Sato, Keiko Sudo, Masayuki Suzuki, Hiroshi Nakai, T Hishida, Takuro Niwa, Kohei Umezu, Satoshi Yuasa,
... this author on: Oxford Academic PubMed Google Scholar Masayuki Suzuki, Masayuki Suzuki ‡Pharmacokinetics and Drug Metabolism Laboratory, Yokohama Research Center, ...
Tópico(s): Liver physiology and pathology
1995 - Oxford University Press | The Journal of Biochemistry
Akimasa Adachi, Mayumi Komine, Masayuki Suzuki, Satoru Murata, Tomoko Hirano, Norito Ishii, Takashi Hashimoto, Mamitaro Ohtsuki,
... JapanSearch for more papers by this authorMasayuki Suzuki, Masayuki Suzuki Department of Dermatology, School of Medicine, Jichi Medical ... JapanSearch for more papers by this authorMasayuki Suzuki, Masayuki Suzuki Department of Dermatology, School of Medicine, Jichi Medical ...
Tópico(s): Skin and Cellular Biology Research
2016 - Wiley | The Journal of Dermatology
Masakazu Ohkita, Takashi Tsuji, Masayuki Suzuki, Masashi Murakami, Shinya Nishida,
... 8,10-tetraen-7-oneMasakazu Ohkita, Takashi Tsuji, Masayuki Suzuki, Masashi Murakami, and Shinya NishidaCite this: J. Org. ...
Tópico(s): Organic Chemistry Cycloaddition Reactions
1990 - American Chemical Society | The Journal of Organic Chemistry
Natsuko Sugihara, Koji Kamiya, Naomi Nakano, Masayuki Suzuki, Takeo Maekawa, Satoru Murata, Mayumi Komine, Mamitaro Ohtsuki,
... JapanSearch for more papers by this authorMasayuki Suzuki, Masayuki Suzuki Department of Dermatology, Jichi Medical University, Shimotsuke City, ... JapanSearch for more papers by this authorMasayuki Suzuki, Masayuki Suzuki Department of Dermatology, Jichi Medical University, Shimotsuke City, ...
Tópico(s): Urticaria and Related Conditions
2023 - Wiley | The Journal of Dermatology
Anders Øverby, Somay Yamagata Murayama, Hirofumi Michimae, Hidekazu Suzuki, Masayuki Suzuki, Hiroshi Serizawa, Ryo Tamura, Shinichi Nakamura, Shinʼichi Takahashi, Masahiko Nakamura,
<b><i>Background:</i></b> Non-<i>Helicobacter pylori</i>-helicobacters (NHPH) compose a group of gram negative zoonotic bacteria that may induce in humans gastric diseases including gastritis, gastroduodenal ulcer and MALT lymphoma. Their prevalence in the general population has previously been reported to 0.1-6.2%, although such reports still remain less in number. <b><i>Aims:</i></b> This study aimed at estimating the prevalence of gastric ...
Tópico(s): Gastroesophageal reflux and treatments
2017 - Karger Publishers | Digestion
Daisuke Asaoka, Akihito Nagahara, Takeshi Matsuhisa, Shinichi Takahashi, K. Tokunaga, Takashi Kawai, Kohei Kawakami, Hidekazu Suzuki, Masayuki Suzuki, Toshihiro Nishizawa, Naoto Kurihara, Masayoshi Ito, Hitoshi Sasaki, Fumio Omata, Shigeaki Mizuno, Akira Torii, Toshifumi� Ohkusa, Tetsuya Mine, Nobuhiro Sakaki,
In Japan, the eradication rate of first-line therapy for Helicobacter pylori (H. pylori) with a proton pump inhibitor (PPI), amoxicillin (AMPC) and clarithromycin (CAM) has been decreasing because of a high prevalence of CAM resistance. A possible decrease of the eradication rate for second-line therapy with a PPI, AMPC and metronidazole (MNZ) is of concern. The aim of this study is to assess the trends in second-line eradication therapy for H. pylori in Japan.We accumulated data retrospectively on patients ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2013 - Wiley | Helicobacter
Toshihiro Nishizawa, Hidekazu Suzuki, Masayuki Suzuki, Masahiko Takahashi, Toshifumi Hibi∥,
The aim of this study was to compare the efficacy and tolerability of the first-line Helicobacter pylori (H. pylori) eradication regimen composed of proton pump inhibitor, clarithromycin, and amoxicillin, with those of a regimen composed of proton pump inhibitor, metronidazole, and amoxicillin. Data of patients, who were administered the first-line H. pylori eradication regimen at Tokyo Medical Center between 2008 and 2011, were reviewed. All patients had H. pylori gastritis without peptic ulcer ...
Tópico(s): Gastrointestinal disorders and treatments
2012 - Society for Free Radical Research Japan | Journal of Clinical Biochemistry and Nutrition
Hidekazu Tonouchi, Masayuki Suzuki, Masayuki Uchida, Munehiro Oda,
Two angiotensin converting enzyme (ACE)-inhibitory peptides were isolated from enzyme modified cheese (EMC) and their amino acid sequences were identified as Leu-Gln-Pro and Met-Ala-Pro. The EMC was prepared by a combination of Protease N, Umamizyme, and Flavourzyme 500L. Both peptides were derived from beta-casein, f 88-90 and f 102-104, respectively. Met-Ala-Pro showed strong ACE inhibitory activity (IC50=0.8 mum) and antihypertensive activity in spontaneously hypertensive rats (SHR) after single ...
Tópico(s): Meat and Animal Product Quality
2008 - Cambridge University Press | Journal of Dairy Research
Akira Matsunaga, Chikahiko Numakura, Takako Kawakami, Yoshihisa Itoh, Isao Kawabata, Ikuto Masakane, Takashi Suzuki, Masayuki Suzuki, Toshikazu Goto, Kouichi Itoh, Kiyoshi Hayasaka,
Immunoglobulin A (IgA) nephropathy results from the abnormal deposition of IgA in the renal mesangium. Genetic factors may be involved in the development and progression of IgA nephropathy. Uteroglobin (UG) is a steroid-inducible, cytokine-like, multifunctional protein with anti-inflammatory and immunomodulatory properties. The knockout or antisense mouse of the UG gene develops renal disease similar to IgA nephropathy. We analyzed the UG gene as a candidate for a predisposing factor in 61 Japanese ...
Tópico(s): Ion Transport and Channel Regulation
2002 - Elsevier BV | American Journal of Kidney Diseases
Y. Teramura, Keiichi Suzuki, Masayuki Suzuki, Fumihiko Kannari,
Synthesis of a coherence function by manipulation of the spectral phase of low-coherent light with a segmented liquid-crystal phase modulator and its application in a low-coherence interferometry are described. Effects of space-time coupling caused at diffractive gratings and second-order dispersion at the spatial light modulator on the coherence function synthesis are theoretically and experimentally verified. Various coherence functions can be shaped with phase-only masks designed by simulated ...
Tópico(s): Glaucoma and retinal disorders
1999 - Optica Publishing Group | Applied Optics
Hidekazu Suzuki, Masayuki Suzuki, Mikiji Mori, Tetsuji Kitahora, Hirokazu Yokoyama, Soichiro Miura, Toshifumi Hibi∥, Hiromasa Ishii,
The possession of the cytotoxin‐associated gene ( cagA ) of Helicobacter pylori is thought to be highly associated with peptic ulcer disease. However, the pathogenic role of cagA is still unknown. We have emphasized the importance of the interrelationship between H. pylori ‐derived ammonia and oxygen radicals from infiltrated leucocytes. The aim of the present study was to explore the relationship between oxygen radical production and H. pylori strain diversity based on cagA possession. An endoscopic ...
Tópico(s): Galectins and Cancer Biology
1998 - Wiley | Journal of Gastroenterology and Hepatology
Mikiji Mori, Hidekazu Suzuki, Masayuki Suzuki, Akemi Kai, Soichiro Miura, Hiromasa Ishii,
Background. Previously, we have reported that toxic oxidants produced by activated neutrophils play a pivotal role in the development of Helicobacter pylori –induced gastric mucosal damage. Microorganisms, however, are characterized by their ability to produce a variety of antioxidant enzymes. This study is designed to measure the oxygen radical scavenging enzymes, such as catalase and superoxide dismutase (SOD), and urease in the supernatant of H. pylori (NCTC11637) suspension. Materials and Methods. ...
Tópico(s): Phytochemistry and Bioactive Compounds
1997 - Wiley | Helicobacter
Kazuyoshi Watanabe, Makoto Suematsu, Megumi Iida, Kiyosumi Takaishi, Yoshio Iizuka, Hidekazu Suzuki, Masayuki Suzuki, Masaharu Tsuchiya, Susumu Tsurufuji,
Rat cytokine-induced neutrophil chemoattractant (CINC) is a member of the IL-8 family, and its human counterpart is gro/MGSA but not IL-8. We ascertained that chemically synthesized CINC was comparable to native CINC/gro with regard to chemotactic activity for rat neutrophils and studied the effect of synthesized CINC/gro on circulating leukocytes in microvascular vessels of rat mesentery. Exposure of rat mesentery to 10(-8)M authentic CINC/gro induced neutrophil adherence to and extravasation from ...
Tópico(s): Acute Ischemic Stroke Management
1992 - Elsevier BV | Experimental and Molecular Pathology
Hidekazu Suzuki, Mikiji Mori, Masayuki Suzuki, Kazushi Sakurai, Soichiro Miura, Hiromasa Ishii,
Colonization of Helicobacter pylori (Hp) to gastric mucosa plays an important role for the pathogenesis of gastric mucosal lesions. We previously reported the importance of monochloramine (NH2Cl), which was derived from the interaction between Hp-urease and infiltrated leukocytes, in the course of Hp-associated gastric mucosal injury. While the longterm infection of Hp in the gastric mucosa is known to be one of the virulent factors which closely link to the gastric carcinogenesis, the details of ...
Tópico(s): Mycobacterium research and diagnosis
1997 - Elsevier BV | Cancer Letters
Hidekazu Suzuki, Soichiro Miura, Masayuki Suzuki, Soichiro Terada, Masahiko Nakamura, Masaharu Tsuchiya,
The integrity of gastric mucosa is well-balanced by an array of defensive mechanisms which protect the mucosa against external aggressive factors. When excessive stimulation of autonomic nervous system (irritation) is induced, microcirculatory disturbances easily lead to the gastric mucosal damage due to the formation of vasoactive mediators and oxygen radicals. In this review, our discussion has been focused on the co-ordinating function of the autonomic nervous system as well as the microcirculation ...
Tópico(s): Neuropeptides and Animal Physiology
1994 - Keio University School of Medicine | The Keio Journal of Medicine
Hidekazu Suzuki, Tatsuhiro Masaoka, Masaharu Miyazawa, Masayuki Suzuki, Soichiro Miura, Hiromasa Ishii,
Since Marshall's discovery before 20 years, Helicobacter pylori (H. pylori) infection is reportedly to be associated with a variety of clinical outcomes including peptic ulcer disease and gastric cancer. The first step of the H. pylori colonization might be its adhesion to the surface epithelial cells, which evokes gastric inflammatory events initiated by neutrophil recruitment from the microcirculation. Mongolian gerbil is one of the suitable animal models for H. pylori infection, which exerts gastric ...
Tópico(s): Eosinophilic Esophagitis
2002 - Keio University School of Medicine | The Keio Journal of Medicine
Hidekazu Suzuki, Mikiji Mori, Aya Sakaguchi, Masayuki Suzuki, Soichiro Miura, Hiromasa Ishii,
C‐X‐C Chemokines play an important role for neutrophil extravasation through microvessels. Although the level of interleukin (IL)‐8 is known to increase in the Helicobacter pylori ‐infected gastric mucosa, another C‐X‐C chemokine, GROα, has not been evaluated in the H. pylori ‐associated gastric mucosal injury. The present study was designed to investigate gastric contents of GROα in relation to those of IL‐8 in the gastric mucosa of H. pylori ‐infected peptic ulcer patients. Thirty‐eight patients with ...
Tópico(s): Veterinary medicine and infectious diseases
1998 - Wiley | Journal of Gastroenterology and Hepatology
Hidekazu Suzuki, Koichi Seto, Mikiji Mori, Masayuki Suzuki, Soichiro Miura, Hiromasa Ishii,
Monochloramine (NH2Cl) is known to be one of the virulence factors in Helicobacter pylori-associated gastric mucosal injury. The present study was designed to examine NH2Cl-evoked DNA fragmentation in the gastric epithelial cell line MKN45. NH2Cl was produced by mixing NH3 with sodium hypochlorite (NaClO). MKN45 cells were exposed to NH2Cl, NH3, or NaClO in Hanks' balanced salt solution. DNA cleavage was evaluated quantitatively by photometeric enzyme immunoassay for the in vitro determination of ...
Tópico(s): Water Treatment and Disinfection
1998 - American Physiological Society | AJP Gastrointestinal and Liver Physiology
Hidekazu Suzuki, Soichiro Miura, Hiroyuki Imaeda, Masayuki Suzuki, Jing Han, Mikiji Mori, Dai Fukumura, Masaharu Tsuchiya, Hiromasa Ishii,
Helicobacter pylori are believed to play an important role in the formation of gastric ulcer in a syndrome characterized by a high urease activity. On the other hand, the production of oxygen radicals and platelet activating factor (PAF) is enhanced in gastric ulcers. The present study is designed to investigate the relationship between the different aspects of gastric mucosal injury, urease activity, oxygen radical production, and PAF content in gastric specimens. Biopsy specimens taken from 35 ...
Tópico(s): Gastric Cancer Management and Outcomes
1996 - Elsevier BV | Free Radical Biology and Medicine
Takeshi Matsuhisa, Takashi Kawai, Tatsuhiro Masaoka, Hidekazu Suzuki, Masayoshi Ito, Yo Kawamura, K. Tokunaga, Masayuki Suzuki, Tetsuya Mine, Shinichi Takahashi, Nobuhiro Sakaki,
Abstract Background: With the increase in the frequency of clarithromycin‐resistant Helicobacter pylori ( H. pylori ), there is rising concern about the decline of the eradication rate of this infection following treatment. The Tokyo Hp Study Group examined the eradication rate in response to a second‐line regimen consisting of proton pump inhibitor (PPI), amoxicillin, and metronidazole by conducting a multicenter study in the Tokyo Metropolitan Area. Materials and Methods: Two hundred and twenty‐eight ...
Tópico(s): Gastric Cancer Management and Outcomes
2006 - Wiley | Helicobacter
Hidekazu Suzuki, Mikiji Mori, Koichi Seto, Akemi Kai, Chizuko Kawaguchi, Masayuki Suzuki, Makoto Suematsu, Tomoyuki Yoneta, Soichiro Miura, Hiromasa Ishii,
Helicobacter pylori colonized gastric mucosa is manifest in a significant neutrophil infiltration with an extensive level of oxyradical formation. Mongolian gerbil is one of the excellent models for H. pylori-infection. The present study was designed to investigate pro- and antioxidant formation in the stomach of H. pylori-positive gerbils. Fourteen male Mongolian gerbils (MGS/Sea) were orally inoculated with H. pylori (ATCC43504) (Hp group) and 15 gerbils were inoculated with the culture media (Control). ...
Tópico(s): Veterinary medicine and infectious diseases
1999 - Elsevier BV | Free Radical Biology and Medicine
Makoto Suematsu, Hidekazu Suzuki, Hiromasa Ishii, Shinzo Kato, Tohru Yanagisawa, Hiroshi Asako, Masayuki Suzuki, Masaharu Tsuchiya,
Intralobular heterogeneity of oxidative stress and its topographic relationship with cell death during low-flow hypoxia were shown in perfused rat liver by digital microfluorography using dichlorofluorestin diacetate, a fluorochrome sensitive to intracellular hydroperoxide formation, and propidium iodide, which labels the nuclei of nonviable cells.The surface of the liver loaded with two precursors was microscopically visualized, and the fluorescence of dichlorofluorescein, a highly fluorescent ...
Tópico(s): Metabolism and Genetic Disorders
1992 - Elsevier BV | Gastroenterology
Hidekazu Suzuki, Tatsuhiro Masaoka, Sachiko Nomura, Yoshinori Hoshino, Kumiko Kurabayashi, Yuriko Minegishi, Masayuki Suzuki, Hiromasa Ishii,
Helicobacter pylori (H. pylori) is a spiral shaped bacterium that resides in the stomach mucosa. Isolation of H. pylori from the stomach mucosa changed the erstwhile widely held belief that the stomach contains no bacteria and is actually sterile. Once H. pylori is safely ensconced in the mucus, it is able to neutralize the acid in the stomach by elaborating an enzyme called urease. Urease converts urea, of which there is an abundant supply in the stomach (derived from saliva and the gastric juice), ...
Tópico(s): Galectins and Cancer Biology
2003 - Keio University School of Medicine | The Keio Journal of Medicine
Hidekazu Suzuki, Masaharu Miyazawa, Shoichi Nagahashi, Mikiji Mori, Koichi Seto, Akemi Kai, Masayuki Suzuki, Soichiro Miura, Hiromasa Ishii,
Tópico(s): Diet, Metabolism, and Disease
2002 - Springer Science+Business Media | Digestive Diseases and Sciences
Yasuhiro Kawasaki, Michio Suzuki, Yoshiki Maeda, Katsumi Urata, Nariyoshi Yamaguchi, Hiroshi Matsuda, K Hisada, Masayuki Suzuki, Tsutomu Takashima,
Tópico(s): Functional Brain Connectivity Studies
1992 - Springer Science+Business Media | European Archives of Psychiatry and Clinical Neuroscience
Takashi Kawai, Shinʼichi Takahashi, Hidekazu Suzuki, Hitoshi Sasaki, Akihito Nagahara, Daisuke Asaoka, Takeshi Matsuhisa, Tatsuhiro Masaoaka, Toshihiro Nishizawa, Masayuki Suzuki, Masayoshi Ito, Naoto Kurihara, Fumio Omata, Shigeaki Mizuno, Akira Torii, Kohei Kawakami, Toshifumi� Ohkusa, K. Tokunaga, Tetsuya Mine, Nobuhiro Sakaki,
Helicobacter pylori (H. pylori) infection is a strong risk factor for the development of gastric cancer. In 2013, the Japanese government approved H. pylori eradication therapy in patients with chronic gastritis as well as peptic ulcer. However, the continuing decline in eradication rates for first-line H. pylori eradication therapies is an urgent problem. In this study, we investigated changes in the first-line eradication rate from 2001 to 2010.Eradication rates for 7-day triple therapy [proton ...
Tópico(s): Eosinophilic Esophagitis
2014 - Wiley | Journal of Gastroenterology and Hepatology
Hideki Mori, Hidekazu Suzuki, Fumio Omata, Tatsuhiro Masaoka, Daisuke Asaoka, Kohei Kawakami, Shigeaki Mizuno, Naoto Kurihara, Akihito Nagahara, Nobuhiro Sakaki, Masayoshi Ito, Yo Kawamura, Masayuki Suzuki, Yuji Shimada, Hitoshi Sasaki, Takeshi Matsuhisa, Akira Torii, Toshihiro Nishizawa, Tetsuya Mine, Toshifumi� Ohkusa, Takashi Kawai, K. Tokunaga, Shinʼichi Takahashi,
The environment surrounding Helicobacter pylori eradication treatment is dramatically changing. Recently, vonoprazan, a first-in-class potassium-competitive acid blocker (P-CAB), was introduced onto the market in 2015. The aging of Japan's demographic structure is becoming pronounced. In this study, we examined the trend of the eradication rate of H. pylori in the metropolitan area and examined factors concerning successful eradication.We collected data from 20 hospitals in the Tokyo metropolitan ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2019 - SAGE Publishing | Therapeutic Advances in Gastroenterology
Satoshi Miyazaki, Yutaka Komiyama, Satoshi Kawanomoto, Yoshiyuki Doi, Hisanori Furusawa, Takashi Hamana, Yusuke Hayashi, Hiroyuki Ikeda, Yukiko Kamata, Hiroshi Karoji, Michitaro Koike, Tomio Kurakami, Shoken M. Miyama, Tomoki Morokuma, Fumiaki Nakata, Kazuhito Namikawa, Hidehiko Nakaya, Kyoji Nariai, Yoshiyuki Obuchi, Yukie Oishi, Norio Okada, Yuki Okura, Philip J. Tait, Tadafumi Takata, Yôko Tanaka, Masayuki Tanaka, Tsuyoshi Terai, Daigo Tomono, Fumihiro Uraguchi, Tomonori Usuda, Yousuke Utsumi, Yoshihiko Yamada, Hitomi Yamanoi, H. Aihara, Hiroki Fujimori, Sogo Mineo, Hironao Miyatake, Masamune Oguri, Tomohisa Uchida, M. Tanaka, Naoki Yasuda, Masahiro Takada, Hitoshi Murayama, Atsushi J. Nishizawa, Naoshi Sugiyama, Masashi Chiba, Toshifumi Futamase, Shiang‐Yu Wang, Hsin-Yo Chen, Paul T. P. Ho, Eric J.-Y. Liaw, Chi-Fang Chiu, Cheng-Lin Ho, Tsang-Chih Lai, Yao-Cheng Lee, D. Z. Jeng, Satoru Iwamura, R. Armstrong, Steve Bickerton, James Bosch, James E. Gunn, Robert H. Lupton, Craig Loomis, P. A. Price, S.G. Smith, Michael A. Strauss, Edwin L. Turner, Hisanori Suzuki, Yasuhito Miyazaki, Masaharu Muramatsu, Koei Yamamoto, Makoto Endo, Yutaka Ezaki, Noboru Ιτο, Noboru Kawaguchi, Satoshi Sofuku, Tomoaki Taniike, Kotaro Akutsu, Naoto Dojo, Kazuyuki Kasumi, Toru Matsuda, Kohei Imoto, Yoshinori Miwa, Masayuki Suzuki, Kunio Takeshi, Hideo Yokota,
Abstract The Hyper Suprime-Cam (HSC) is an 870 megapixel prime focus optical imaging camera for the 8.2 m Subaru telescope. The wide-field corrector delivers sharp images of 0${^{\prime\prime}_{.}}$2 (FWHM) in the HSC-i band over the entire 1${^{\circ}_{.}}$5 diameter field of view. The collimation of the camera with respect to the optical axis of the primary mirror is done with hexapod actuators, the mechanical accuracy of which is a few microns. Analysis of the remaining wavefront error in off-focus ...
Tópico(s): Astronomy and Astrophysical Research
2017 - Oxford University Press | Publications of the Astronomical Society of Japan
Hisashi Matsumoto, Masayuki Suzuki, Tohru Kamata, Masahiro Kanno,
Matsumoto, Hisashi MD; Suzuki, Masayuki MD; Kamata, Tohru MD; Kanno, Masahiro MD Author Information
Tópico(s): Pneumothorax, Barotrauma, Emphysema
1998 - Lippincott Williams & Wilkins | Journal of Trauma and Acute Care Surgery