Serena Ambrosini, Massimo Serra, Sudhirkumar Shinde, Börje Sellergren, Ersilia De Lorenzi,
Two series of molecularly imprinted polymers (MIPs) for the class-selective recognition of glucuronides have been prepared by using lipophilic substructures of the target analyte as template molecule and potent host monomers against oxyanions, that are expected to establish a strong stoichiometric interaction with the single carboxylic group of the template. The polymers were tested as stationary phases in liquid chromatography for specific recognition. A preliminary investigation of the imprinting ...
Tópico(s): Forensic Toxicology and Drug Analysis
2011 - Elsevier BV | Journal of Chromatography A
Sandra Columba‐Cabezas, Barbara Serafini, Elena Ambrosini, Massimo Sanchez, Giuseppe Penna, Luciano Adorini, Francesca Aloisi,
Macrophage-derived chemokine (MDC/CCL22) and its receptor CCR4 have been implicated in chronic inflammatory processes and in the homing of monocytes, Th2 cells and regulatory T-cell subsets. Here, we demonstrate that MDC and CCR4 mRNAs are expressed in the central nervous system (CNS) of mice developing relapsing–remitting and chronic–relapsing forms of experimental autoimmune encephalomyelitis (EAE). By immunohistochemistry, we show that MDC is produced by CNS-infiltrating leukocytes and intraparenchymal ...
Tópico(s): Immunotherapy and Immune Responses
2002 - Elsevier BV | Journal of Neuroimmunology
Milena Villarini, Maria Vittoria Ambrosini, Massimo Moretti, Luca Dominici, Elena Taha, Danilo Piobbico, Cristiana Gambelunghe, Giuseppina Mariucci,
Purpose: To determine whether a dose-response relationship exists among exposure to extremely low frequency magnetic fields (ELF-MF) at different densities and 70-kDa heat shock protein (hsp70) expression and DNA damage in mouse brain.Materials and methods: Male CD1 mice were exposed to ELF-MF (50 Hz; 0.1, 0.2, 1 or 2 mT) for 7 days (15 h/day) and sacrificed either at the end of exposure or after 24 h. Hsp70 expression was determined in cerebral cortex-striatum, hippocampus and cerebellum by real-time ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2013 - Taylor & Francis | International Journal of Radiation Biology
Arsela Prelaj, Monica Ganzinelli, Francesco Trovò, Laila C. Roisman, Alessandra Pedrocchi, Sokol Kosta, Marcello Restelli, Emilia Ambrosini, Massimo Broggini, Gabriella Pravettoni, Dario Monzani, Alessandro Nuara, Ramon Amat, Nikos Spathas, Michael C. Willis, Alexander T. Pearson, James M. Dolezal, Laura Mazzeo, Sabina Sangaletti, Ana Correa, Alfonso Aguarón, Iris Watermann, Crina Popa, Giulia Raimondi, Tiziana Triulzi, Stefan Steurer, Giuseppe Lo Russo, Helena Linardou, Nir Peled, Enriqueta Felip, Martin Reck, Marina Chiara Garassino,
Although immunotherapy (IO) has changed the paradigm for the treatment of patients with advanced non-small cell lung cancers (aNSCLC), only around 30% to 50% of treated patients experience a long-term benefit from IO. Furthermore, the identification of the 30 to 50% of patients who respond remains a major challenge, as programmed Death-Ligand 1 (PD-L1) is currently the only biomarker used to predict the outcome of IO in NSCLC patients despite its limited efficacy. Considering the dynamic complexity ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2023 - Elsevier BV | Clinical Lung Cancer
Ciro Indolfi, Federico Piscione, Enrico Russolillo, Bruno Villari, Paolo Golino, Vittorio Ambrosini, M Condorelli, Massimo Chiariello,
This study evaluated the effect of bolus infusion of digoxin (0.014 mg/kg in 10 minutes, intravenously) on large coronary arteries measured by quantitative digital angiography. Twenty-two patients (mean age +/- standard deviation 47 +/- 12 years) divided into 3 groups were studied. The effects of digoxin infusion (after 10 and 20 minutes) and sublingual administration of isosorbide dinitrate were investigated in group I (patients with angiographically normal coronary arteries, n = 9) and in group II (patients ...
Tópico(s): Kawasaki Disease and Coronary Complications
1991 - Elsevier BV | The American Journal of Cardiology
Produção Nacional
Revisado por pares
Giuseppe Lamberti, Francesco Panzuto, Marianne Pavel, Dermot O’Toole, Valentina Ambrosini, Massimo Falconi, Rocio García‐Carbonero, Rachel P. Riechelmann, Guido Rindi, Davide Campana,
Tópico(s): Gastrointestinal Tumor Research and Treatment
2024 - Nature Portfolio | Nature Reviews Disease Primers
Giovanni Fucá, Andrea Spagnoletti, Margherita Ambrosini, Filippo de Braud, Massimo Di Nicola,
•Immune cell engagers (ICEs) are molecules able to redirect immune effector cells against cancer cells.•ICEs can be used for the redirection of T cells, natural killer (NK) cells and cytotoxic/phagocytic cells.•ICEs have the potential for enabling a feasible and effective redirection of effector cells in patients with solid tumors.•ICEs design, antigen specificity and heterogeneity and immunosuppressive microenvironment are major issues in solid tumors. In the landscape of cancer immunotherapy, immune ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Elsevier BV | ESMO Open
Vittorio Montefusco, Francesca Gay, Francesco Spina, Maria Teresa Ambrosini, Massimo Maniezzo, Lucia Farina, Alba Miceli, Antonio Palumbo, Mario Boccadoro, Paolo Corradini,
Abstract Osteonecrosis of the jaw (ONJ) is a frequent complication in bisphosphonate-treated multiple myeloma (MM) patients. The pathogenesis is unclear, and major risk factors are duration of bisphosphonate treatment and dental procedures. The histology of osteonecrotic bone shows osteomyelitis and inflammatory infiltrates, and, in most cases, presence of Actynomycetes. Since dental procedures are a major risk factor for ONJ development and oral microflora can be involved in the pathogenesis of the ...
Tópico(s): Oral health in cancer treatment
2007 - Elsevier BV | Blood
Giovanni Randon, Giulia Maddalena, Marco Maria Germani, Chiara Pircher, Paolo Manca, Francesca Bergamo, Mirella Giordano, Caterina Sposetti, Aldo Montagna, Guglielmo Vetere, Luca Zambelli, Cosimo Rasola, Alessandra Boccaccino, Filippo Pagani, Margherita Ambrosini, Marco Massafra, Gabriella Fontanini, Massimo Milione, Matteo Fassan, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio,
Several uncommon genomic alterations beyond RAS and BRAFV600E mutations drive primary resistance to anti-epidermal growth factor receptors (EGFRs) in metastatic colorectal cancer (mCRC). Our PRESSING panel (including PIK3CA exon 20/AKT1/PTEN mutations, ERBB2/MET amplifications, gene fusions, and microsatellite instability-high status) represented a paradigm of negative hyperselection with more precise tailoring of EGFR blockade. However, a modest proportion of hyperselected mCRC has intrinsic resistance ...
Tópico(s): Gastric Cancer Management and Outcomes
2022 - Lippincott Williams & Wilkins | JCO Precision Oncology
Pv Lippolis, Sara Tognini, Gabriele Materazzi, Antonio Polini, Rita Mancini, Carlo Enrico Ambrosini, Angela Dardano, Fulvio Basolo, Massimo Seccia, Paolo Miccoli, Fabio Monzani,
Although fine-needle aspiration cytology remains the mainstay of the preoperative workup of thyroid nodules, those with follicular proliferation still represent a diagnostic challenge. Real-time elastography (RTE) estimates the stiffness/elasticity of lesions and is regarded as a promising technique for the presurgical selection of thyroid nodules (including those with indeterminate cytology).Our aim was to verify the potential role of RTE in the presurgical diagnosis of cancer in a large cohort of ...
Tópico(s): Ovarian cancer diagnosis and treatment
2011 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Giuseppe Brancatelli, Michael P. Federle, Roberta Ambrosini, Roberto Lagalla, Alessandro Carriero, Massimo Midiri, Valérie Vilgrain,
In this article, we present the CT and MR imaging characteristics of the cirrhotic liver. We describe the altered liver morphology in different forms of viral, alcoholic and autoimmune end-stage liver disease. We present the spectrum of imaging findings in portal hypertension, such as splenomegaly, ascites and varices. We describe the patchy and lacelike patterns of fibrosis, along with the focal confluent form. The process of hepatocarcinogenesis is detailed, from regenerative to dysplastic nodules ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2006 - Elsevier BV | European Journal of Radiology
Dario Ambrosini, V. Bagini, F. Gori, Massimo Santarsiero,
Abstract We present a simple model in which a twisted Gaussian Schell-model beam is produced by an incoherent superposition of ordinary Gaussian beams. The meaning and some direct consequences of the model are given.
Tópico(s): Plasmonic and Surface Plasmon Research
1994 - Taylor & Francis | Journal of Modern Optics
Giuseppe Giannini, M Ambrosini, Lucia Di Marcotullio, Fabio Cerignoli, Massimo Zani, Andrew R. Mackay, Isabella Screpanti, Luigi Frati, Alberto Gulino,
Abstract The abnormal activation of the epidermal growth factor (EGF) pathway is one of the most common findings in human cancer, and a number of molecular devices of laboratory and clinical relevance have been designed to block this transduction pathway. Because of the large number of cellular events that might be regulated through the activation of the four EGF receptor family members, it is possible that screening methodologies for the identification of new molecular targets working downstream ...
Tópico(s): Genomics and Chromatin Dynamics
2003 - Wiley | Molecular Carcinogenesis
Cecilia Clivati, Giovanni Antonio Costanzo, M. Frittelli, Filippo Levi, Alberto Mura, Massimo Zucco, Roberto Ambrosini, C. Bortolotti, Federico Perini, Mauro Roma, Davide Calonico,
We realize a coherent fiber link for application in very long baseline interferometry (VLBI) for radio astronomy and geodesy. A 550-km optical fiber connects the Italian National Metrological Institute (INRIM) to a radio telescope in Italy and is used for the primary Cs fountain clock stability and accuracy dissemination. We use an ultrastable laser frequency- referenced to the primary standard as a transfer oscillator; at the radio telescope, an RF signal is generated from the laser by using an optical ...
Tópico(s): Geophysics and Sensor Technology
2015 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control
Eleonora Porcu, Stefano Venturoli, Giuseppe Damiano, PM Ciotti, Leonardo Notarangelo, Roberto Paradisi, Massimo Moscarini, Guido Ambrosini,
Anti-neoplastic treatments have significantly increased the survival of cancer patients, but female patients risk premature menopause. Oocyte cryopreservation has been proposed as a fertility-saving option. This report describes the first live birth achieved with autologous cryopreserved oocytes in an ovariectomized borderline cancer patient. A patient with a borderline ovarian tumour asked for oocyte cryopreservation after a right adnexectomy. Ovulation induction resulted in the retrieval and cryopreservation ...
Tópico(s): Ovarian function and disorders
2008 - Elsevier BV | Reproductive BioMedicine Online
Massimo Castorina, A Ambrosini, Alessandro Giuliani, Licia Pacifici, M. T. Ramacci, Luciano Angelucci,
Aging is associated with a reduction in the maximum density of n-methyl-d-aspartate (NMDA)-sensitive glutamate binding sites in the hippocampus of Fischer 344 rats. This study was designed to investigate the effect of acetyl-l-carnitine (ALCAR) on NMDA receptors in the old rat (24 months) after chronic or single-dose treatments. The number of NMDA receptors was significantly decreased in the old rat hippocampus by 19.5% compared with the young rat. A six-month treatment with ALCAR in the old rat attenuated ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
1993 - Elsevier BV | Experimental Gerontology
Sarah Costantino, Alexander Akhmedov, Giovanni Melina, S A Mohammed, Alaa Othman, Samuele Ambrosini, Winandus J. Wijnen, Lidia Sada, Giuseppino Massimo Ciavarella, Luca Liberale, Felix C. Tanner, Christian M. Matter, Thorsten Hornemann, Massimo Volpe, Fatima Mechta‐Grigoriou, Giovanni G. Camici, Riccardo Sinatra, Thomas F. Lüscher, Francesco Paneni,
Metabolic cardiomyopathy (MC)—characterized by intra-myocardial triglyceride (TG) accumulation and lipotoxic damage—is an emerging cause of heart failure in obese patients. Yet, its mechanisms remain poorly understood. The Activator Protein 1 (AP-1) member JunD was recently identified as a key modulator of hepatic lipid metabolism in obese mice. The present study investigates the role of JunD in obesity-induced MC. JunD transcriptional activity was increased in hearts from diet-induced obese (DIO) mice ...
Tópico(s): Cardiovascular Function and Risk Factors
2018 - Oxford University Press | European Heart Journal
Giulio Di Cosmo, Marcello Costantini, Ettore Ambrosini, Anatolia Salone, Giovanni Martinotti, M. Corbo, Massimo Di Giannantonio, Francesca Ferri,
According to the dimensional approach to psychosis, there is a continuum from low schizotypy to schizophrenia patients. The temporal aspect of sensory processing seems to be compromised across such continuum, as suggested by different studies separately investigating unisensory or multisensory domains. Most of these studies have so far focused primarily on the temporal processing of visual and auditory stimuli, either in schizotypy or schizophrenia, while leaving the tactile domain and the integration ...
Tópico(s): Hallucinations in medical conditions
2020 - Elsevier BV | Journal of Psychiatric Research
Vittorio Montefusco, Francesca Gay, Francesco Spina, Rosalba Miceli, Massimo Maniezzo, Maria Teresa Ambrosini, Lucia Farina, Sheila Piva, Antonio Palumbo, Mario Boccadoro, Paolo Corradini,
Osteonecrosis of the jaw (ONJ) can be a severe complication of patients with multiple myeloma (MM) treated with bisphosphonates. Dental procedures are a major risk factor for ONJ occurrence. We retrospectively analysed the data of 178 patients with MM to evaluate if antibiotic prophylaxis before dental procedures may prevent ONJ. A correlation between dental procedures, antibiotic prophylaxis, incidence of ONJ and relevant clinical features was performed. Overall nine out of 178 patients developed ...
Tópico(s): Osteomyelitis and Bone Disorders Research
2008 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Andrea Ambrosini‐Spaltro, Luca Morandi, Dominic V. Spagnolo, Alberto Cavazza, Massimo Brisigotti, Stefania Damiani, Sanjiv Jain, Vincenzo Eusebi,
Tópico(s): Oral and Maxillofacial Pathology
2010 - Springer Science+Business Media | Virchows Archiv
Stefania Forciniti, Elisa Dalla Pozza, Maria Raffaella Greco, Tiago M. A. Carvalho, Barbara Rolando, Giulia Ambrosini, Cristian Andres Carmona‐Carmona, Raffaella Pacchiana, Daria Di Molfetta, Massimo Donadelli, Silvia Arpicco, Marta Palmieri, Stephan J. Reshkin, Ilaria Dando, Rosa Angela Cardone,
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease. Gemcitabine (GEM) is used as the gold standard drug in PDAC treatment. However, due to its poor efficacy, it remains urgent to identify novel strategies to overcome resistance issues. In this context, an intense stroma reaction and the presence of cancer stem cells (CSCs) have been shown to influence PDAC aggressiveness, metastatic potential, and chemoresistance. Methods: We used three-dimensional (3D) organotypic cultures ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Thomas Länger, Francesca Carmela Depalo, Clarissa Forlini, Silvia Landini, Andrea Mezzetti, Paola Previtali, Gianpaola Monti, Carolina De Toma, Davide Biscardi, Alberto Giannini, Roberto Fumagalli, Giovanni Mistraletti, Barbara Lissoni, Andrea Martini, Nadia Mareto, Concetta Rossitto, Ugo Zummo, Martina Taverna, Patrizia Machieraldo, Mauro Navarra, Massimiliano Parlanti Garbero, Chiara Scaletti, Silvia Perno, Luca Amendolia, Giorgia Montrucchio, Deliana Veliaj, Giuseppe Barbarello, Maria Alesci, Luca Bolgiaghi, Davide Vailati, Angelo Pezzi, Enrico Boselli, Francesca Piccoli, Massimiliano Greco, Marco Gemma, Marco Resta, Stefania Crotti, Nicola Bottino, Chiara Abruzzese, M. Savioli, Giuseppina Migliorino, Stefano Muttini, Michele Umbrello, Beatrice Borghi, Massimiliano Greco, Micaela Dizeo, Maurizio Bottiroli, Michele Mondino, Manlio Prosepri, Giampaolo Casella, Francesco Lo Curto, Matteo Zaniboni, Riccardo Giudici, Carlo Gentile, Michela Bombino, Roberto J. Rona, Barbara Cortinovis, Annalisa Benini, Leonello Avalli, Mario Tavola, Matteo Ferrario, Roberta Preda, Enzo Primerano, Gianluca Russo, Virginia Porta, Federico Valdambrini, Paola Fassini, Serena Orando, Eduardo Beck, Matteo Pedeferri, Giacomina Cogliati, Denise Testini, Benedetta Moroni, Vito Codeluppi, Patrizia Ruggeri, Elisa Milanesi, Mirko Belliato, Alessandra Besozzi, Mario Riccio, Silvia Zerbi, Davide Corbella, Francesco Ferri, Lorenzo Grazioli, Ezio Bonanomi, Matteo Giacomini, Noemi Sacchi, Cristian Codognola, Alessandra Ambrosini, Luca Guatteri, Matteo Subert, Gian Paolo Castelli, Massimo Borelli, Erica Venier, Loredana Dittura, Stefania Buttera, Roberto Bigai, Sandra Magnoni, Simon Rauch, Angelo Colombo, Giorgio Fullin, Caterina Donolato, Silvia Cattin, Veronica State, Enrico Redeghieri, Alessandro Russo, Simonetta Pastorini, Sandra Allena, Marina Munari, Federica Turchet, Mario Peta, Vincenzo De Santis, Cristina Scala, Francesca Facondini, Elisabetta Marangoni, Tania Tassinati, Chiara Zanzani, Emanuele Russo, Annamaria Marchio, Maria Barbagallo, Massimo Girardis, Paolo Taffache, Marco Mordacci, Matteo Vincenzi, Michele Pennica, Giovanna Bracciotti, Paola Iori, D Gambi, Iacopo Cappellini, Lara Vegnuti, Alessandra De Luca, Stefano Romagnoli, Giamila Mosti, Rossella Carla, Valeria Roticiani, Lorella Pelagalli, Ennio Fuselli, Emilio D’Avino, Massimo De Bellis, G Gianni, Francesca Leonardis, Marzia Rossi, Rossana Lorusso, Eugenia Magnanimi, Sabrina Martelli, F Baisi, Davide Balsamo, Virginia Cotticelli, Alessia Mattei, Ivano Farinelli, Teresa Riccini, Luisanna Cola, Antonella Jorio, Emanuele Iacobone, Roberta Domizi, Simone Pizzi, Armando Nasso, Romano Graziani, Anna Monaco, Manuela Manno, Carla Maria Ottelio, Michela Del Rio, Antonio Serra, Barbara Enna, Francesco Marco Loddo, Rita Galbiati, Serena Mellea, Michelle Brozzi Kimberly, Matteo Vissani, Francesco Massimo Romito, Laura Baccari, Nadia Zarrillo, Clelia Esposito, Patrizia Murino, Salvatore Notaro, Carmine Ausiello, Annachiara Marra, Carmela Policastro, Chiara Cafora, Giuseppe De Benedectis, Vincenzo Di Falco, Maria Sciddurlo, Giancarlo Negro, Paolo Vetuschi, Andrea Recchia, Rita Pasquariello, Rosalba Squillace, Antonio Ciambrone, Carmela Bencivenga, Melania Camiolo, Cristina Agozzino, Francesco Oliveri, Tiziana Notarrigo, Giacomo Castiglione, Antonella Mo, Laura Condorelli, Martina Favarato,
Abstract Background During the first coronavirus disease 2019 (COVID-19) pandemic wave, an unprecedented number of patients with respiratory failure due to a new, highly contagious virus needed hospitalization and intensive care unit (ICU) admission. The aim of the present study was to describe the communication and visiting policies of Italian intensive care units (ICUs) during the first COVID-19 pandemic wave and national lockdown and compare these data with prepandemic conditions. Methods A national ...
Tópico(s): COVID-19 and Mental Health
2022 - BioMed Central | BMC Anesthesiology
Daniela Zuccarello, Alberto Ferlin, Andrea Garolla, Massimo Menegazzo, Lisa Perilli, Guido Ambrosini, Carlo Foresta,
For fertilization to occur in mammals, ejaculated spermatozoa must reach the egg which, following ovulation has moved from the ovary into the Fallopian tube. Two active mechanisms of spermatozoa guidance have been shown in mammals: thermotaxis and chemotaxis. The identity of most of human spermatozoa chemoattractants is unknown, and herein we tested if SDF1 (chemokine stromal cell-derived factor-1) and its pathway is involved in spermatozoa chemotaxis. We found that SDF1 is expressed in the oocytes, ...
Tópico(s): Sperm and Testicular Function
2011 - Wiley | Andrology
Marta Laganà, Salvatore Grisanti, Deborah Cosentini, Vittorio Ferrari, Barbara Lazzari, Roberta Ambrosini, Chiara Sardini, Alberto Dalla Volta, Carlotta Palumbo, Pietro Luigi Poliani, Massimo Terzolo, Sandra Sigala, Guido Alberto Massimo Tiberio, Alfredo Berruti,
Etoposide, doxorubicin and cisplatin plus oral mitotane (EDP-M) comprise the reference regimen in the management of patients with adrenocortical carcinoma (ACC). In this paper, we described the outcome of 58 patients with advanced/metastatic ACC consecutively treated with EDP-M in a reference center for this rare disease in Italy. In this series, EDP-M obtained a partial response in 50% of patients; median progression free survival (PFS) and overall survival were 10.1 months (95% Confidence Interval [ ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2020 - Multidisciplinary Digital Publishing Institute | Cancers
V. Bagini, Dario Ambrosini, Giuseppe Schirripa Spagnolo, Riccardo Borghi, F. Gori, A. M. Pacileo, Massimo Santarsiero,
Flattened Gaussian beams are characterized by a waist profile that passes in a continuous way from a nearly flat illuminated region to darkness. The steepness of the transition region is controlled by an integer parameter N representing the order of the beam. Being expressible as a sum of N Laguerre–Gauss modes, a flattened Gaussian beam turns out to be very simple to study as far as propagation is concerned. We investigate the main features of the field distribution pertaining to a flattened Gaussian ...
Tópico(s): Photonic Crystal and Fiber Optics
1996 - Optica Publishing Group | Journal of the Optical Society of America A
Antonio Palumbo, Ilaria Avonto, Benedetto Bruno, Antonietta Falcone, Potito Rosario Scalzulli, Maria Teresa Ambrosini, Sara Bringhen, Francesca Gay, Cecilia Rus, Federica Cavallo, Patrizia Falco, Massimo Massaia, Pellegrino Musto, Mario Boccadoro,
Bortezomib and thalidomide have shown synergy with melphalan and dexamethasone. We used this 4-drug combination as conditioning before autologous hematopoietic cell infusions.Twenty-six patients with advanced-stage myeloma were treated with melphalan 50 mg/m(2) and bortezomib 1.3 mg/m(2) on days -6 and -3 in association with thalidomide 200 mg and dexamethasone 20 mg on days -6 through -3, followed by hematopoietic cell support on day 0.Nonhematologic toxicities included pneumonia, febrile neutropenia, ...
Tópico(s): Cancer Treatment and Pharmacology
2006 - Elsevier BV | Clinical Lymphoma & Myeloma
Andrea Garolla, Ilaria Cosci, Massimo Menegazzo, Raffaella De Palo, Guido Ambrosini, Barabara Sartini, Damiano Pizzol, Carlo Foresta,
ObjectiveTo evaluate DNA fragmentation in single sperm selected by both birefringence and motile sperm organelle morphology examination (MSOME) with a single instrument.DesignProspective study.SettingUniversity setting.Patient(s)Semen samples from 33 normozoospermic subjects.Intervention(s)Birefringence and MSOME to distinguish different categories of sperm: nonbirefringent (category A), birefringent (category B), birefringent with nuclear vacuoles (category C), and birefringent with no nuclear vacuoles ( ...
Tópico(s): Reproductive Health and Technologies
2013 - Elsevier BV | Fertility and Sterility
Ilaria Dando, Elisa Dalla Pozza, Giulia Ambrosini, Margalida Torrens‐Mas, Giovanna Butera, Nidula Mullappilly, Raffaella Pacchiana, Marta Palmieri, Massimo Donadelli,
ABSTRACT Tumour repopulation is recognized as a crucial event in tumour relapse where therapy‐sensitive dying cancer cells influence the tumour microenvironment to sustain therapy‐resistant cancer cell growth. Recent studies highlight the role of the oncometabolites succinate, fumarate, and 2‐hydroxyglutarate in the aggressiveness of cancer cells and in the worsening of the patient's clinical outcome. These oncometabolites can be produced and secreted by cancer and/or surrounding cells, modifying ...
Tópico(s): Histone Deacetylase Inhibitors Research
2019 - Wiley | Biological reviews/Biological reviews of the Cambridge Philosophical Society
Kjell Öberg, Eric P. Krenning, Anders Sundin, Lisa Bodei, Mark Kidd, Margot Tesselaar, Valentina Ambrosini, Richard P. Baum, Matthew H. Kulke, Marianne Pavel, Jarosław B. Ćwikła, Ignat Drozdov, Massimo Falconi, Nicola Fazio, Andrea Frilling, Robert T. Jensen, Klaas Pieter Koopmans, Tiny Korse, Dik J. Kwekkeboom, Helmut R. Maëcke, Giovanni Paganelli, Ramón Salazar, Stefano Severi, Jonathan Strosberg, Vikas Prasad, Aldo Scarpa, Ashley Grossman, Annemeik Walenkamp, Mauro Cives, Irene Virgolini, Andreas Kjær, Irvin M. Modlin,
The complexity of the clinical management of neuroendocrine neoplasia (NEN) is exacerbated by limitations in imaging modalities and a paucity of clinically useful biomarkers. Limitations in currently available imaging modalities reflect difficulties in measuring an intrinsically indolent disease, resolution inadequacies and inter-/intra-facility device variability and that RECIST (Response Evaluation Criteria in Solid Tumors) criteria are not optimal for NEN. Limitations of currently used biomarkers ...
Tópico(s): Neuroblastoma Research and Treatments
2016 - Bioscientifica | Endocrine Connections
Cristina Grossi, Stefania Rigacci, Stefano Ambrosini, Teresa Ed Dami, Ilaria Luccarini, Chiara Traini, Paola Failli, Andrea Berti, Fiorella Casamenti, Massimo Stefani,
The claimed beneficial effects of the Mediterranean diet include prevention of several age-related dysfunctions including neurodegenerative diseases and Alzheimer-like pathology. These effects have been related to the protection against cognitive decline associated with aging and disease by a number of polyphenols found in red wine and extra virgin olive oil. The double transgenic TgCRND8 mice (overexpressing the Swedish and Indiana mutations in the human amyloid precursor protein), aged 1.5 and ...
Tópico(s): Edible Oils Quality and Analysis
2013 - Public Library of Science | PLoS ONE