Jordi Temprana‐Salvador, Pablo López-García, Josep Castellví, Lluís de Haro, Eudald Ballesta, Matias Rojas Abusleme, Miquel Arrufat, Ferran Marqués, Josep R. Casas, Carlos Gallego, Laura Pons, José Luís Mate, Pedro L. Fernández, Eugeni López‐Bonet, Ramón Bosch, S. Martínez, Santiago Ramón y Cajal, Xavier Matías‐Guiu,
Complete digital pathology transformation for primary histopathological diagnosis is a challenging yet rewarding endeavor. Its advantages are clear with more efficient workflows, but there are many technical and functional difficulties to be faced. The Catalan Health Institute (ICS) has started its DigiPatICS project, aiming to deploy digital pathology in an integrative, holistic, and comprehensive way within a network of 8 hospitals, over 168 pathologists, and over 1 million slides each year. We ...
Tópico(s): Cancer Genomics and Diagnostics
2022 - Multidisciplinary Digital Publishing Institute | Diagnostics
Luis Rozas, Rubén Boroschek, Aldo Tamburrino, Matías Rojas,
In this article, a new bidirectional tuned liquid column damper (BTLCD) is proposed for controlling the seismic response of structures. The device acts as two independent and orthogonal tuned liquid column dampers (TLCDs), but due to its configuration, it requires less liquid than two equivalent independent TLCDs. The equations of motion of the system formed by the BTLCD and the primary structure to be controlled are obtained by means of Lagrangian dynamics explicitly considering the non-symetrical ...
Tópico(s): Vibration and Dynamic Analysis
2015 - Wiley | Structural Control and Health Monitoring
Christian Berger, Nancy L. Deutsch, Olga Cuadros, Eduardo Franco-Chalco, Matías Rojas, Gabriela Roux, F.S. Lozano Sánchez,
During adolescence, peer processes play a significant role in development. Whereas peer relations have been studied extensively in the school context, far less research has examined peer processes that occur within extracurricular and out-of-school time activities. This study used focus groups to explore the role of peer processes in shaping developmental processes and outcomes across four distinct types of out-of-school activities in Santiago, Chile. Across all extracurricular activities, three ...
Tópico(s): Early Childhood Education and Development
2020 - Elsevier BV | Children and Youth Services Review
Matías Rojas, Miguél Nussbaum, Pablo Chiuminatto, Orlando Guerrero, Samuel Greiff, Florian Krieger, Lindie van der Westhuizen,
As 21st century skills have become increasingly important, Collaborative Problem Solving (CPS) is now considered essential in almost all areas of life. Different theoretical frameworks and assessment instruments have emerged for measuring this skill. However, more applied studies on its implementation and evaluation in real-life educational settings are required. In this sense, pre-post experimental designs are essential for identifying new methods for developing collaborative problem-solving skills. ...
Tópico(s): Education and Critical Thinking Development
2021 - Elsevier BV | Computers & Education
Pablo Báez, Felipe Bravo-Márquez, Jocelyn Dunstan, Matías Rojas, Fabián Villena,
Here we describe a new clinical corpus rich in nested entities and a series of neural models to identify them. The corpus comprises de-identified referrals from the waiting list in Chilean public hospitals. A subset of 5,000 referrals (58.6% medical and 41.4% dental) was manually annotated with 10 types of entities, six attributes, and pairs of relations with clinical relevance. In total, there are 110,771 annotated tokens. A trained medical doctor or dentist annotated these referrals, and then, ...
Tópico(s): Natural Language Processing Techniques
2022 - Association for Computing Machinery | ACM Transactions on Computing for Healthcare
Matías Rojas, Miguél Nussbaum, Orlando Guerrero, Pablo Chiuminatto, Samuel Greiff, Rodrigo Del Río, Danilo Alvares,
Tópico(s): Educational Games and Gamification
2022 - Springer Science+Business Media | International Journal of Computer-Supported Collaborative Learning
Joaquín Montero, Matías Rojas, Josette Castel, Mónica Muñoz, Astrid Brunner, Yuvitza Sáez, Judith Scharager,
A survey about the competences required by primary health physicians in Chile Background: Primary health care is considered the cornerstone of health care in Chile.Its efficiency is strongly influenced by the quality and competences of physicians that are responsible for health care at this level.Aim: To define the features and competences that should have primary care physicians.Material and methods: A group of experts that could be physicians or other professionals working in primary health care ...
Tópico(s): Healthcare Systems and Technology
2009 - Q16635223 | Revista médica de Chile
Cristián Sandoval-Acuña, Sebastián Fuentes-Retamal, Daniela Guzmán‐Rivera, Liliana Peredo-Silva, Matías Madrid-Rojas, Solange Rebolledo, Vicente Castro-Castillo, Mario Pavani, Mabel Catalán, Juan Diego Maya, José A. Jara, Eduardo Parra, Gloria M. Calaf, Hernán Speisky, Jorge Ferreira,
Mitochondrion is an accepted molecular target in cancer treatment since it exhibits a higher transmembrane potential in cancer cells, making it susceptible to be targeted by lipophilic-delocalized cations of triphenylphosphonium (TPP+). Thus, we evaluated five TPP+-linked decyl polyhydroxybenzoates as potential cytotoxic agents in several human breast cancer cell lines that differ in estrogen receptor and HER2/neu expression, and in metabolic profile. Results showed that all cell lines tested were ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2016 - Elsevier BV | Toxicology and Applied Pharmacology
Camilo Herrera‐Leyton, Matías Madrid‐Rojas, Jhon J. López, Álvaro Cañete, Patricio Hermosilla‐Ibáñez, Edwin G. Pérez,
Abstract The mild and fast copper‐catalyzed radical and regioselective aminoalkoxylation of styrenes by using N ‐fluorobenzenesulfonimide and simple alcohols as nitrogen and alkoxy sources, respectively, was investigated. The aminoalkoxylated products obtained could be used in the synthesis of new compounds with possible activity as neurotransmitter receptor ligands.
Tópico(s): Sulfur-Based Synthesis Techniques
2016 - Wiley | ChemCatChem
Liliana Peredo-Silva, Sebastián Fuentes-Retamal, Cristián Sandoval-Acuña, Mario Pavani, Juan Diego Maya, Vicente Castro-Castillo, Matías Madrid-Rojas, Solange Rebolledo, Ulrike Kemmerling, Eduardo Parra, Jorge Luís Ferreira,
We previously demonstrated that alkyl gallates coupled to triphenylphosphine have a selective and efficient antiproliferative effect by inducing mitochondrial uncoupling in vitro due to the increased mitochondrial transmembrane potential of tumor cells. Therefore, in this work, the in vivo antitumor activities of alkyl gallate triphenylphosphonium derivatives (TPP+ C8, TPP+ C10 and TPP+ C12) were evaluated in a syngeneic murine model of breast cancer. We found that TPP+ C10 increased the cytosolic ...
Tópico(s): Tannin, Tannase and Anticancer Activities
2017 - Elsevier BV | Toxicology and Applied Pharmacology
Matias Aguilera‐Rojas, Brit Badewien-Rentzsch, Johanna Plendl, Barbara Kohn, Ralf Einspanier,
Exosomes are defined as extracellular membrane vesicles, 30-150 nm in diameter, derived from all types of cells. They originate via endocytosis and then they are released through exocytosis to the extracellular space, being found in various biological fluids as well as in cell culture medium. In the last few years, exosomes have gained considerable scientific interest due to their potential use as biomarkers, especially in the field of cancer research. This report describes a method to isolate, ...
Tópico(s): Machine Learning and ELM
2018 - BioMed Central | BMC Veterinary Research
Matías Gabriel Rojas, Ana Carolina Olivera, Pablo Javier Vidal,
In recent years, technology in medicine has shown a significant advance due to artificial intelligence becoming a framework to make accurate medical diagnoses. Models like Multilayer Perceptrons (MLPs) can detect implicit patterns in data, allowing identifying patients conditions that cannot be seen easily. MLPs consist of biased neurons arranged in layers, connected by weighted connections. Their effectiveness depends on finding the optimal weights and biases that reduce the classification error, ...
Tópico(s): Metaheuristic Optimization Algorithms Research
2022 - Elsevier BV | Array
Chloe B. Fishman, Kate D Crawford, Santi Bhattarai-Kline, Darshini Poola, Karen Zhang, Alejandro González-Delgado, Matías Rojas-Montero, Seth L. Shipman,
Tópico(s): RNA and protein synthesis mechanisms
2024 - Nature Portfolio | Nature Biotechnology
Asim G Khan, Matías Rojas-Montero, Alejandro González-Delgado, Santiago C. Lopez, Rebecca Fang, Kate D Crawford, Seth L. Shipman,
Tópico(s): Cytomegalovirus and herpesvirus research
2024 - Nature Portfolio | Nature Biotechnology
Danisa M. L. Ferrero, Claudia V. Piattoni, Matías D. Asención Diez, Bruno E. Rojas, Matías D. Hartman, Miguel A. Ballícora, Alberto Á. Iglesias,
Starch is the dominant reserve polysaccharide accumulated in the seed of grasses (like wheat). It is the most common carbohydrate in the human diet and a material applied to the bioplastics and biofuels industry. Hence, the complete understanding of starch metabolism is critical to design rational strategies to improve its allocation in plant reserve tissues. ADP-glucose pyrophosphorylase (ADP-Glc PPase) catalyzes the key (regulated) step in the synthetic starch pathway. The enzyme comprises a small ( ...
Tópico(s): Plant tissue culture and regeneration
2020 - Frontiers Media | Frontiers in Plant Science
Alejandro González-Delgado, Santiago C. Lopez, Matías Rojas-Montero, Chloe B. Fishman, Seth L. Shipman,
Tópico(s): Plant Virus Research Studies
2024 - Nature Portfolio | Nature Chemical Biology
Roberto Cárdenas, Matías Díaz, Félix Rojas, John Clare,
Delayed signal cancellation is one of the methods used to separate the negative- and positive-sequence components in unbalanced 3φ systems. In this letter, a DSC methodology with fast convergence time is proposed and it is shown that an improved separation of the positive and negative sequences is feasible. Experimental results are presented to demonstrate the performance of the proposed methodology.
Tópico(s): Cellular Automata and Applications
2014 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Delivery
Roberto Cárdenas, Matías Díaz, Félix Rojas, John Clare, Patrick Wheeler,
Owing to the high penetration of electrical energy from wind energy conversion systems (WECSs), some countries are enforcing stringent grid codes to regulate low-voltage-ride-through (LVRT) operation of WECSs. This study presents a self-tuning resonant control (RC) system which can be used for LVRT control of the grid interface in the presence of symmetrical or asymmetrical faults. Only two RCs are required to fully control the four degrees of freedom of the converter output current. Sequence component ...
Tópico(s): Microgrid Control and Optimization
2016 - Institution of Engineering and Technology | IET Power Electronics
Matías Cavelli, Daniel Rojas‐Líbano, Natalia Schwarzkopf, Santiago Castro‐Zaballa, Joaqúın González, Alejandra Mondino, Noelia Santana, Luciana Benedetto, Atilio Falconi, Pablo Torterolo,
Abstract Recently, a novel type of fast cortical oscillatory activity that occurs between 110 and 160 Hz (high‐frequency oscillations ( HFO )) was described. HFO are modulated by the theta rhythm in hippocampus and neocortex during active wakefulness and REM sleep. As theta‐ HFO coupling increases during REM , a role for HFO in memory consolidation has been proposed. However, global properties such as the cortex‐wide topographic distribution and the cortico‐cortical coherence remain unknown. In this study, ...
Tópico(s): Photoreceptor and optogenetics research
2017 - Wiley | European Journal of Neuroscience
Matías Tagle, Francisca Rojas, Felipe Reyes, Yeanice Vásquez, Fredrik Hallgren, Jenny Lindén, Dimitar Kolev, Ågot K. Watne, Pedro Oyola,
Abstract Integration of low-cost air quality sensors with the internet of things (IoT) has become a feasible approach towards the development of smart cities. Several studies have assessed the performance of low-cost air quality sensors by comparing their measurements with reference instruments. We examined the performance of a low-cost IoT particulate matter (PM 10 and PM 2.5 ) sensor in the urban environment of Santiago, Chile. The prototype was assembled from a PM 10 –PM 2.5 sensor (SDS011), a temperature ...
Tópico(s): Vehicle emissions and performance
2020 - Springer Science+Business Media | Environmental Monitoring and Assessment
José Aravena, Dante Carrasco, Matías Díaz, Matías Uriarte, Félix Rojas, Roberto Cárdenas, Juan Carlos Travieso‐Torres,
In recent years, different off-the-shelf solutions for the rapid control prototyping of power electronics converters have been commercialised. The main benefits of those systems are based on a fast and easy-to-use environment due to high-level programming. However, most of those systems are very expensive and are closed software and hardware solutions. In this context, this paper presents the design and implementation of a control platform targeting at the segment in between expensive off-the-shelf ...
Tópico(s): Microgrid Control and Optimization
2020 - Multidisciplinary Digital Publishing Institute | Energies
Matías Gabriel Rojas, Ana Carolina Olivera, Jessica Andrea Carballido, Pablo Javier Vidal,
Gene selection aims at identifying a -small- subset of informative genes from the initial data to obtain high predictive accuracy for classification in human cancers. Gene selection can be considered as a combinatorial search problem and thus can be conveniently handled with optimization methods. This paper proposes a Memetic Cellular Genetic Algorithm (MCGA) to solve the Feature Selection problem of cancer microarray datasets. Benchmark gene expression datasets, i.e., colon, lymphoma, and leukaemia ...
Tópico(s): Evolutionary Algorithms and Applications
2020 - Institute of Electrical and Electronics Engineers | IEEE Latin America Transactions
Matias Aguilera‐Rojas, Soroush Sharbati, Torsten Stein, Mario Candela Andrade, Barbara Kohn, Ralf Einspanier,
Circulating microRNAs (miRNAs) are described as promising non-invasive biomarkers for diagnostics and therapeutics. Human studies have shown that haemolysis occurring during blood collection or due to improper sample processing/storage significantly alters the miRNA content in plasma and serum. Nevertheless, no similar research has been performed in dogs so far. We therefore investigated the effects of different degrees of haemolysis on the levels of selected miRNAs in serum and serum-derived extracellular ...
Tópico(s): RNA Interference and Gene Delivery
2022 - BioMed Central | BMC Veterinary Research
Jorge Saavedra‐Olavarría, Matías Madrid‐Rojas, Iriux Almodóvar, Patricio Hermosilla‐Ibáñez, Edwin G. Pérez,
A regioselective, copper-catalyzed, one-pot aminoalkoxylation of styrenes using primary and secondary alcohols and three different iminoiodanes as alkoxy and nitrogen sources respectively, is reported. The β-alkoxy-N-protected phenethylamines obtained were used to synthesise β-alkoxy-N-benzylphenethylamines which are interesting new compounds that could act as possible neuronal ligands.
Tópico(s): Sulfur-Based Synthesis Techniques
2018 - Royal Society of Chemistry | RSC Advances
Matías Gabriel Rojas, Ana Carolina Olivera, Jessica Andrea Carballido, Pablo Javier Vidal,
Fast and precise medical diagnosis of human cancer is crucial for treatment decisions. Gene selection consists of identifying a set of informative genes from microarray data to allow high predictive accuracy in human cancer classification. This task is a combinatorial search problem, and optimisation methods can be applied for its resolution. In this paper, two memetic micro-genetic algorithms (MμV1 and MμV2) with different hybridisation approaches are proposed for feature selection of cancer microarray ...
Tópico(s): Metaheuristic Optimization Algorithms Research
2023 - Elsevier BV | Intelligent Systems with Applications
Carolina Martı́nez, D.P. Rojas, Matías Quezada, Jorge Quezada, Ricardo Oliva,
Earthquakes and tsunamis are significant factors for change along active margin shores, and influence coastal evolution. The Chilean coast was affected in 2010 by a subduction earthquake with a magnitude of Mw 8.8 and also by a trans-Pacific tsunami, which generated violent geomorphologic changes and damaged homes. Following these events, the magnitude of the changes which affect Chile's central-southern coast (37°S) and the role of subduction earthquakes in coastal evolution on a historical scale ...
Tópico(s): Geology and Paleoclimatology Research
2015 - Elsevier BV | Geomorphology
Rute Irgang, Rodrigo Hiroshi González-Luna, Jorge L. Gutiérrez, Matías Poblete‐Morales, Verónica Rojas, Diana Tapia‐Cammas, Rubén Avendaño‐Herrera,
Journal of Fish DiseasesVolume 40, Issue 12 p. 1915-1920 SHORT COMMUNICATION First identification and characterization of Tenacibaculum dicentrarchi isolated from Chilean red conger eel (Genypterus chilensis, Guichenot 1848) R Irgang, R Irgang Universidad Andres Bello, Laboratorio de Patología de Organismos Acuáticos y Biotecnología Acuícola, Viña del Mar, Chile Interdisciplinary Center for Aquaculture Research (INCAR), Concepción, ChileSearch for more papers by this authorR González-Luna, R González- ...
Tópico(s): Aquaculture Nutrition and Growth
2017 - Wiley | Journal of Fish Diseases
Christian A. Rojas, Matías Aguirre, Samir Kouro, Tobias Geyer, Eduardo Quevedo,
This paper proposes and validates model predictive control as an alternative control strategy for H-bridgeneutral-point-clamped (H-NPC) converters for single-phase grid-tied string photovoltaic (PV) systems. The presented control scheme achieves good quality current waveforms with unity power factor, dc-link voltage control, and neutral-point voltage minimization. Furthermore, the predictive controller has been further enhanced by including an average device switching frequency restriction and a dv/ ...
Tópico(s): Advanced DC-DC Converters
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industrial Electronics
Rafael Brahm, Néstor Espinoza, M. Rabus, Andrés Jordán, Matías R. Díaz, Felipe Rojas, M. Vučković, A. Zapata, C. Cortés, H. Drass, J. S. Jenkins, R. Lachaume, B. Pantoja, P. Sarkis, M. G. Soto, S. Vásquez, Th. Henning, M. I. Jones,
We report the discovery of EPIC 201498078b, which was first identified as a planetary candidate from Kepler K2 photometry of Campaign 14, and whose planetary nature and orbital parameters were then confirmed with precision radial velocities. EPIC 201498078b is half as massive as Saturn ($\rm M_P$=$0.179 \pm 0.021$ $\rm M_J$), and has a radius of $\rm R_P$=$0.840 \pm 0.011$ $\rm R_J$, which translates into a bulk density of $ \rm \rho_P$=$0.37 \pm 0.05$ g cm$^{-3}$. EPIC 201498078b transits its slightly evolved ...
Tópico(s): Astrophysics and Star Formation Studies
2018 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Rocío Elizabeth Gallardo Jara, Matías C. Ghiglione, Lisandro Rojas Galliani,
The evolutionary history of the Austral Magallanes has been object of several studies both in Chile and Argentina, due to its importance as hydrocarbon and gas producer. In the evolution of southern South America, a stage of intracratonic rifting development between the Middle-Late Jurassic has been recognized in a wide part of southern Patagonia that generated an extensional basin (Rocas Verdes basin). Following the creation of a synrift fault system the basins evolved towards an Early Cretaceous ...
Tópico(s): Geological and Geochemical Analysis
2019 - | Latin American journal of sedimentology and basin analysis