Clara Abadesso, Pedro Nunes, Catarina Silvestre, Ester Matias, Helena Loureiro, Helena Almeida,
The aim of this paper is to assess the clinical efficacy of non-invasive ventilation (NIV) in avoiding endotracheal intubation (ETI), to demonstrate clinical and gasometric improvement and to identify predictive risk factors associated with NIV failure. An observational prospective clinical study was carried out. Included Patients with acute respiratory disease (ARD) treated with NIV, from November 2006 to January 2010 in a Pediatric Intensive Care Unit (PICU). NIV was used in 151 patients with acute ...
Tópico(s): Nosocomial Infections in ICU
2012 - Multidisciplinary Digital Publishing Institute | Pediatric Reports
Catarina Silvestre, Joaquim Sampaio Matias, Helena Proença, Maria João Bugalho,
Introduction: Calcitonin (Ctn) is a hormone secreted by thyroid "C" cells and is considered an excellent marker for medullary thyroid carcinoma (MTC). However, the use of Ctn to screen patients with nodular thyroid disease (NTD) remains controversial. Objective: The aim of this work was to define the frequency of hypercalcitoninemia among NTD patients followed at a tertiary referral hospital. Methods: A retrospective analysis was made of basal Ctn measurements and corresponding patients' records between ...
Tópico(s): Pituitary Gland Disorders and Treatments
2018 - | European Thyroid Journal
Mariana Matias, Samuel Silvestre, Amílcar Falcão, Gilberto Alves,
Purpose - During the discovery and development of new drugs, compounds with low aqueous solubility pose special challenges in their pharmacological evaluation and, therefore, the selection of appropriate vehicles to administer the compounds of interest is determinant for the quality of the results generated during the in vivo non-clinical studies. This work aimed to evaluate the motor deficit (as a surrogate of neurotoxicity) of several administration/delivery vehicles through the rotarod performance ...
Tópico(s): Analytical Methods in Pharmaceuticals
2018 - Canadian Society for Pharmaceutical Sciences | Journal of Pharmacy & Pharmaceutical Sciences
Mariana Matias, Samuel Silvestre, Amílcar Falcão, Gilberto Alves,
Molecular hybridization is a recent strategy based on the covalent fusion of two or more pharmacophores to create a single molecule with multiple mechanisms of action, which represents an encouraging approach in the development of new drugs with potential therapeutic application in several pathologies. This review provides a comprehensive perspective of the most relevant advances in the development of hybrid molecules acting in the central nervous system. For instance, several opioid hybrids based ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2016 - Bentham Science Publishers | Mini-Reviews in Medicinal Chemistry
Mariana Matias, Samuel Silvestre, Amílcar Falcão, Gilberto Alves,
Gastrodia elata Blume (G. elata) is a traditional Chinese herb used for centuries in folk medicine. Due to the claimed anticonvulsant properties of G. elata, it is expected that this herb continues to be a target of research, aiming to deepen the available knowledge on its biological activity and safety.The current review aims to discuss the most recent advances on the elucidation of the phytochemical composition and anticonvulsant potential of G. elata.Available literature was reviewed from PubMed, ...
Tópico(s): Ginseng Biological Effects and Applications
2016 - Elsevier BV | Phytomedicine
Ângela Gonçalves, Mariana Matias, Jorge A. R. Salvador, Samuel Silvestre,
Bismuth compounds are considered relatively non-toxic, with their low solubility in aqueous solutions (e.g., biological fluids) being the major contributing factor to this property. Bismuth derivatives are widely used for the treatment of peptic ulcers, functional dyspepsia, and chronic gastritis. Moreover, the properties of bismuth compounds have also been extensively explored in two main fields of action: antimicrobial and anticancer. Despite the clinical interest of bismuth-based drugs, several ...
Tópico(s): Potassium and Related Disorders
2024 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Marta Moniz, Catarina Silvestre, Pedro Nunes, Clara Abadesso, Ester Matias, Helena Loureiro, Helena Almeida,
The aim of the study was to describe the experience with high-frequency oscillatory ventilation (HFOV) in a Portuguese Pediatric Critical Care Unit, and to evaluate whether HFOV allowed improvement in oxygenation and ventilation.This was a retrospective observational cohort study of children ventilated by HFOV between January, 2002 and December, 2011. The following parameters were recorded: demographic and clinical data, and blood gases and ventilatory parameters during the first 48 hours of HFOV. ...
Tópico(s): Family and Patient Care in Intensive Care Units
2013 - Elsevier BV | Jornal de Pediatria
Produção Nacional
Revisado por pares
Cecilia Montiel‐Nava, Sebastián Cukier, Gabriela Garrido, Daniel Valdez, Cristiane Silvestre Paula, Ricardo Navarro García, Analía Rosoli, Matías Irarrázaval, Alexia Rattazzi,
Core symptoms of Autism Spectrum Disorder (ASD) continue to affect everyday life as children grow and transition into adulthood. That way, different services may be needed at various stages of their lifetimes. This study aimed to describe service encounters and hours of service per week for individuals with ASD in Latin American countries and compare the data from three age groups (preschoolers, school-aged, and adolescents). The data were obtained from an online survey adapted by Red Espectro Autista ...
Tópico(s): Family and Disability Support Research
2020 - Elsevier BV | Research in autism spectrum disorders
Produção Nacional
Revisado por pares
Cristiane Silvestre Paula, Sebastián Cukier, Graccielle R. Cunha, Matías Irarrázaval, Cecilia Montiel‐Nava, Ricardo Navarro García, Analía Rosoli, Daniel Valdez, Daniela Bordini, Andy Shih, Gabriela Garrido, Alexia Rattazzi,
Lack of access to services and support is an important issue for people with autism, but in low- and middle-income countries there is a lack of data on this problem. The aims of this study were to describe the challenges and priorities, identify barriers to care, and map stigma among families of individuals with autism in Latin America. This survey was undertaken by the Red Espectro Autista Latinoamerica network, a coalition of researchers/clinicians from six Latin American countries; it comprised ...
Tópico(s): Child Nutrition and Feeding Issues
2020 - SAGE Publishing | Autism
Produção Nacional
Revisado por pares
Carlos De la Fuente, Alejandro Neira, Gustavo Foa Torres, Rony Silvestre, Matías Roby, Roberto Yáñez, Sofía Alaínez Herrera, Virgina Martabit, Isabel McKay, Felipe P. Carpes,
Crutches can help with the locomotion of people with walking disorders or functional limitations. However, little is known about hip muscle activation during stair ascending using different crutch locomotion patterns in people without disorders and limitations. Thus, we determined the acute effects of elbow crutch locomotion on gluteus medius (GM) activity during stair ascending. This comparative analytic cross-sectional study enrolled ten healthy men (22.0 ± 0.47 years). Participants climbed up the ...
Tópico(s): Cerebral Palsy and Movement Disorders
2022 - Frontiers Media | Frontiers in Bioengineering and Biotechnology
proposición se informan sin solución de continuidad.
Tópico(s): Urbanism, Landscape, and Tourism Studies
2019 - University of Santiago de Compostela | Agora papeles de Filosofía
recrea, para solución de determinadas polémicas de las últimas dos décadas, en una genealogía de su pensamiento político.A este respecto, léase con atención la bella introducción de Federico L. Silvestre, "Non serviam" (pp.13-27).Malos tratos, orfanato y una suerte de profecía: "A los catorce años, recuerdo haber hecho un pacto conmigo mismo: no sería ni verdugo ni víctima" (p.32).
Tópico(s): Philosophical and Cultural Analysis
2019 - University of Santiago de Compostela | Agora papeles de Filosofía
Produção Nacional
Revisado por pares
Gláucia M.M. Guedes, Anísio Silvestre Pinheiro Santos-Filho, Wanessa Fernandes Matias Regis, Crister José Ocadaque, Bruno Rocha Amando, José Júlio Costa Sidrim, Raimunda Sâmia Nogueira Brilhante, Rossana de Aguiar Cordeiro, Silviane Praciano Bandeira, Marcos Fábio Gadelha Rocha, Débora de Souza Collares Maia Castelo‐Branco,
Aim This study aimed to assess an ex situ model of biofilm-associated wounds on porcine skin for the study of Staphylococcus aureus and Pseudomonas aeruginosa biofilms in a host-like environment, after 48 to 120 h of incubation. Material and results Ex situ and in vitro biofilms were comparatively analysed. Overall, CFU-counts and matrix quantification yielded significantly (P < 0·05) higher results for ex situ than in vitro biofilms. Confocal microscopy revealed greater (P < 0·05) biomass and thickness ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2021 - Oxford University Press | Journal of Applied Microbiology
... 2021): 310.https://doi.org/10.3390/insects12040310João Silvestre, Sílvia Pires, Vitória Pereira, Miguel Colaço, Ana Costa, Amadeu Soares, Domitília Matias, Filipa Bettencourt, Sergio Fernández-Boo, Rui Rocha, Andreia ...
Tópico(s): Sports Performance and Training
2001 - University of Chicago Press | The American Naturalist
Raymond B. Huey, David Berrigan,
... 2021): 310.https://doi.org/10.3390/insects12040310João Silvestre, Sílvia Pires, Vitória Pereira, Miguel Colaço, Ana Costa, Amadeu Soares, Domitília Matias, Filipa Bettencourt, Sergio Fernández-Boo, Rui Rocha, Andreia ...
Tópico(s): Evolution and Genetic Dynamics
2001 - University of Chicago Press | The American Naturalist
Raquel Urtasun, María Elizalde, María Azkona, María U. Latasa, Oihane García‐Irigoyen, Iker Uriarte, Maite G. Fernández‐Barrena, Silvestre Vicent, Marta M. Alonso, Jordi Muntané, Jesús Prìeto, Matías A. Ávila, Carmen Berasain,
Resisting death is a central hallmark of cancer cells. Tumors rely on a number of genetic mechanisms to avoid apoptosis, and alterations in mRNA alternative splicing are increasingly recognized to have a role in tumorigenesis. In this study, we identify the splicing regulator SLU7 as an essential factor for the preservation of hepatocellular carcinoma (HCC) cells viability. Compared with hepatocytes, SLU7 expression is reduced in HCC cells; however, further SLU7 depletion triggered autophagy-related ...
Tópico(s): MicroRNA in disease regulation
2016 - Springer Nature | Oncogene
Mariana Matias, Gonçalo Campos, Samuel Silvestre, Amílcar Falcão, Gilberto Alves,
Although significant advances are occurring in epilepsy research, about 30% of epileptic patients are still inadequately controlled by standard drug therapy. For this reason, it continues to be important to develop new chemical entities through which epilepsy could be effectively controlled. In this study, the anticonvulsant activity of forty-two dihydropyrimidin(thi)ones was explored and their efficacy was evaluated in rodents against the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2017 - Elsevier BV | European Journal of Pharmaceutical Sciences
Produção Nacional
Revisado por pares
Salomão Israel Monteiro Lourenço Queiroz, Gleysson Matias de Assis, Valéria Damasceno Silvestre, Adriano Rocha Germano, José Sandro Pereira da Silva,
Hemangiomas are benign neoplasms that are common in the head and neck, but relatively rare in the oral cavity. They can cause esthetic and functional impairment, depending on location. The most common site is the upper lip, but they can occur in other areas, such as the tongue, buccal mucosa and palate. Treatment is primarily dependent on correct diagnosis of the lesion and on its anatomic location. The purpose of this article is to provide a description of a case of a hemangioma on the upper lip, ...
Tópico(s): Oral and Maxillofacial Pathology
2014 - Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV) | Jornal Vascular Brasileiro
Produção Nacional
Revisado por pares
Carlos De la Fuente, Rony Silvestre, Roberto Yáñez, Matías Roby, Macarena Soldán, Wilson Ferrada, Felipe P. Carpes,
Injury risk is regularly assessed during the preseason in susceptible populations like female soccer players. However, multiple outcomes (high-dimensional dataset) derived from multiple testing may make pattern recognition difficult. Thus, dimension reduction and clustering may be useful for improving injury surveillance when results of multiple assessment tools are available.To determine the influence of dimension reduction for pattern recognition followed by clustering on multiple biomechanical ...
Tópico(s): Lower Extremity Biomechanics and Pathologies
2022 - Taylor & Francis | Science and Medicine in Football
Produção Nacional
Revisado por pares
Luís Paulo Souza e Souza, Gabriel Silvestre Minucci, Andrea Matias Alves, Rauni Jandé Roama Alves, Marconi Moura Fernandes,
Objective: discuss the reality of ensuring the health care of LGBTQ + people while striving for solidification of human rights against public health policies in the brazilian prison system. Methodology: theoretical research, analyzing books, articles and official documents of the government. Results: LGBTQ+ people, political minorities, have historically been placed on the sidelines of social media, such as family, school, work, leisure, access to justice and health, finding in peripheral experiences, ...
Tópico(s): Gender, Sexuality, and Education
2020 - FUNDAÇÃO OSWALDO CRUZ | CADERNOS IBERO-AMERICANOS DE DIREITO SANITÁRIO
Produção Nacional
Revisado por pares
Nilton Nélio Cometti, Gean Carlos Silva Matias, Everaldo Zonta, Wellington Mary, Mânlio Silvestre Fernandes,
Foi avaliado o crescimento da alface (Lactuca sativa L.) cv 'Vera' em um sistema hidropônico NFT com diferentes concentrações da solução nutritiva. O experimento foi realizado em casa de vegetação de abril a maio de 2000, na UFRRJ, Seropédica (RJ). Os tratamentos constaram de quatro soluções nutritivas, diferentes quanto à concentração de macronutrientes: 100; 50; 25 e 12,5% da concentração original proposta por Furlani (1997). A produção de massa seca (parte comercial) em solução nutritiva a 50% da ...
Tópico(s): Soil Management and Crop Yield
2008 - Associação Brasileira de Olericultura | Horticultura Brasileira
Produção Nacional
Revisado por pares
Nilton Nélio Cometti, Gean Carlos Silva Matias, Everaldo Zonta, Wellington Mary, Mânlio Silvestre Fernandes,
O presente trabalho foi realizado na UFRRJ e teve como objetivo verificar as variações de alguns componentes metabólicos nos tecidos da alface. Plantas de alface do tipo crespa, da cultivar Verônica, provenientes de três sistemas de cultivo, orgânico, hidropônico e convencional, foram separadas em oito partes (limbo das folhas basais, medianas e apicais, nervura central das folhas basais, medianas e apicais, caule e raiz). Foram analisados nitrato, N-amino, açúcares livres e distribuição da massa ...
Tópico(s): Cassava research and cyanide
2004 - Associação Brasileira de Olericultura | Horticultura Brasileira
Rosana Quintana, Adriana Silvestre, Mario Goñi, Vanina García, Nora Mathern, Marisa Jorfen, Julio Miljevic, Daniel Dhair, Matias Laithe, Silvana Conti, Fadua Midauar, Maria Celeste Martin, Maria Cecilia Barrios, Romina Nieto, Cristina Prigione, Álvaro Sanabria, Viviana Gervasoni, Emilio Grabbe, Romina Patricia Gontero, Ingris Peláez‐Ballestas, Bernardo A. Pons‐Estel,
This study aimed to estimate the prevalence of musculoskeletal disorders and rheumatic diseases among the indigenous Qom (Toba) population in the city of Rosario, Santa Fe, Argentina. An analytical cross-sectional study using methodology of the Community Oriented Program for the Control of Rheumatic Diseases (COPCORD) was performed. Subjects ≥18 years of age were interviewed by advanced students of medicine and nursing, bilingual translator-facilitators, and coordinators. Individuals with musculoskeletal ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2016 - Springer Science+Business Media | Clinical Rheumatology
Pedro Taborda, Hugo Matias, Daniel Silvestre, Pedro Lourenço,
This paper delves into a rendezvous scenario involving a chaser and a target spacecraft, focusing on the application of Model Predictive Control (MPC) to design a controller capable of guiding the chaser toward the target. The operational principle of spacecraft thrusters, requiring a minimum activation time that leads to the existence of a control deadband, introduces mixed-integer constraints into the optimization, posing a considerable computational challenge due to the exponential complexity ...
Tópico(s): Spacecraft Design and Technology
2024 - Institute of Electrical and Electronics Engineers | IEEE Control Systems Letters
Marta Moniz, Catarina Silvestre, Pedro Nunes, Clara Abadesso, Ester Matias, Helena Loureiro, Helena Almeida,
The aim of the study was to describe the experience with high-frequency oscillatory ventilation (HFOV) in a Portuguese Pediatric Critical Care Unit, and to evaluate whether HFOV allowed improvement in oxygenation and ventilation. This was a retrospective observational cohort study of children ventilated by HFOV between January, 2002 and December, 2011. The following parameters were recorded: demographic and clinical data, and blood gases and ventilatory parameters during the first 48 hours of HFOV. ...
Tópico(s): Cardiac Arrest and Resuscitation
2013 - Elsevier BV | Jornal de Pediatria (Versão em Português)
Mariana Matias, Adriana O. Santos, Samuel Silvestre, Gilberto Alves,
Epilepsy is a chronic and complex condition and is one of the most common neurological diseases, affecting about 50 million people worldwide. Pharmacological therapy has been, and is likely to remain, the main treatment approach for this disease. Although a large number of new antiseizure drugs (ASDs) has been introduced into the market in the last few years, many patients suffer from uncontrolled seizures, demanding the development of more effective therapies. Nanomedicines have emerged as a promising ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2023 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Mariana Matias, Gonçalo Campos, Adriana O. Santos, Amílcar Falcão, Samuel Silvestre, Gilberto Alves,
A series of 3,4-dihydropyrimidin-2-(1H)-thiones (1–22) was synthesized through the Biginelli reaction in order to find novel anticancer drug candidates based on the structure of monastrol. The antiproliferative activity of the compounds was screened in several cell lines and the chlorinated compounds expressed considerable cytotoxicity in hepatic and/or colon and MCF-7 breast cancer cell lines. Within these, compound 11 was the most potent and showed strong antiproliferative effects on HepaRG cells ( ...
Tópico(s): Computational Drug Discovery Methods
2016 - Elsevier BV | Arabian Journal of Chemistry
Mariana Matias, Gonçalo Campos, Adriana O. Santos, Amílcar Falcão, Samuel Silvestre, Gilberto Alves,
The search for novel anticancer agents with higher selectivity and lower toxicity remains a medical need.
Tópico(s): Quinazolinone synthesis and applications
2016 - Royal Society of Chemistry | RSC Advances
João Guilherme Silvestre, Sílvia F. S. Pires, Vitòria Pereira, Miguel Bruno Félix Colaço, Ana P.L. Costa, Amadeu M.V.M. Soares, Domitília Matias, Filipa Bettencourt, Sergio Fernández‐Boo, Rui J. M. Rocha, Andreia C. M. Rodrigues,
Microbiological contamination of bivalve molluscs is one of the major concerns inherent to food safety, thus depuration is frequently needed to assure food safety levels associated with their consumption. Salinity plays an important role in the metabolic activity of bivalves and as such can influence their depuration capacity. This study aimed to evaluate the effect of salinity (25, 30, 35 and 40) on the efficiency of the depuration process, along with the quality and shelf-life of Crassostrea gigas. ...
Tópico(s): Calcium Carbonate Crystallization and Inhibition
2021 - Multidisciplinary Digital Publishing Institute | Water
Mariana Matias, Ana Fortuna, Joana Bicker, Samuel Silvestre, Amílcar Falcão, Gilberto Alves,
The heterocycles dihydropyrimidin(thi)ones have been under intensive pharmacological research, but their pharmacokinetic properties remain almost unknown. Herein, fifty dihydropyrimidin(thi)ones were submitted to in vitro screening tests using parallel artificial membrane permeability assays (PAMPA) to evaluate their apparent permeability (Papp) through intestinal membrane and blood-brain barrier models, and cell-based assays to assess their interference on the efflux transporter P-glycoprotein (P- ...
Tópico(s): Metal complexes synthesis and properties
2017 - Elsevier BV | European Journal of Pharmaceutical Sciences