Ania C. Muntau, Wulf Röschinger, Matthias Habich, Hans Demmelmair, B. Hoffmann, Christian P. Sommerhoff, Adelbert A. Roscher,
Hyperphenylalaninemia is a common inherited metabolic disease that is due to phenylalanine hydroxylase deficiency, and at least half the affected patients have mild clinical phenotypes. Treatment with a low-phenylalanine diet represents a substantial psychosocial burden, but alternative treatments have not been effective.
Tópico(s): Metabolomics and Mass Spectrometry Studies
2002 - Massachusetts Medical Society | New England Journal of Medicine
Grischa Beier, André Ullrich, Silke Niehoff, Malte Reißig, Matthias Habich,
Industry 4.0 has had a strong influence on the debate on the digitalization of industrial processes, despite being criticized for lacking a proper definition. However, Industry 4.0 might offer a huge chance to align the goals of a sustainable development with the ongoing digital transformation in industrial development. The main contribution of this paper is therefore twofold. We provide a de-facto definition of the concept "Industry 4.0" from a sociotechnical perspective based on its most often ...
Tópico(s): Big Data and Business Intelligence
2020 - Elsevier BV | Journal of Cleaner Production
Kristina Döring, Nabeel Ahmed, Trine Riemer, Harsha Garadi Suresh, Yevhen Vainshtein, Markus Habich, Jan Riemer, Matthias P. Mayer, Edward P. O’Brien, Günter Krämer, Bernd Bukau,
The yeast Hsp70 chaperone Ssb interacts with ribosomes and nascent polypeptides to assist protein folding. To reveal its working principle, we determined the nascent chain-binding pattern of Ssb at near-residue resolution by in vivo selective ribosome profiling. Ssb associates broadly with cytosolic, nuclear, and hitherto unknown substrate classes of mitochondrial and endoplasmic reticulum (ER) nascent proteins, supporting its general chaperone function. Ssb engages most substrates by multiple binding- ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2017 - Cell Press | Cell
Günter Klöppel, Matthias Löhr, Klaus Habich, M. Oberholzer, Philipp U. Heitz,
The present review draws attention to the diversity of islet lesions seen in human type 1 and type 2 diabetes. This heterogeneity of islet changes is best demonstrated by immunocytochemistry. In type 1 diabetes the endocrine pancreas is characterized by selective loss of B cells, which most likely results from a slowly acting autoimmune process depending on the presence of both genetic and environmental factors. The process starts years before overt diabetes develops and manifests when the B-cell ...
Tópico(s): Pancreatic function and diabetes
1985 - Karger Publishers | Pathology and Immunopathology Research
Matthias Böehm, Dirk Habich, Steffen Preißler, Wolfgang Lehner, Uwe Wloka,
Tópico(s): Service-Oriented Architecture and Web Services
2010 - Elsevier BV | Information Systems
Olaf Weber, J Reefschläger, Helga Rübsamen‐Waigmann, Siegfried Raddatz, Matthias Hesseling, Dieter Häbich,
Novel peptide aldehydes (PAs) were identified as potent inhibitors of human cytomegalovirus (HCMV) in vitro. Although these compounds were highly effective against HCMV, they did not exhibit any activity against murine cytomegalovirus (MCMV). The purpose of this study was to test the antiviral activity of PA 8 as a representative of this novel class of inhibitors against HCMV in vivo. Because of the strict species specificity of HCMV we had to use two artificial animal models. In the first model, HCMV- ...
Tópico(s): Adenosine and Purinergic Signaling
2000 - SAGE Publishing | Antiviral chemistry & chemotherapy
Jerónimo Castrillón, Jochen Fröhlich, Andrés Goens, Sebastian Haas, Dirk Habich, Hermann Härtig, Mattis Hasler, Immo Huismann, Tomas Karnagel, Sven Karol, Akash Kumar, Matthias Lieber, Wolfgang Lehner, Linda Leuschner, Siqi Ling, Steffen Märcker, Christian Menard, Johannes Mey, Wolfgang E. Nagel, Benedikt Nöthen, Rafael Peñaloza, Michael Raitza, Sascha Klüppelholz, Jörg Stiller, Annett Ungethüm, Axel Voigt, Sascha Wunderlich, Marcus Völp, Nils Asmussen, Uwe Aßmann, Franz Baader, Christel Baier, Gerhard Fettweis,
Plenty of novel emerging technologies are being proposed and evaluated today, mostly at the device and circuit levels. It is unclear what the impact of different new technologies at the system level will be. What is clear, however, is that new technologies will make their way into systems and will increase the already high complexity of heterogeneous parallel computing platforms, making it ever so difficult to program them. This paper discusses a programming stack for heterogeneous systems that ...
Tópico(s): Radiation Effects in Electronics
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Multi-Scale Computing Systems
Matthias Böehm, Dirk Habich, Wolfgang Lehner,
Integration flows are used to propagate data between heterogeneous operational systems or to consolidate data into data warehouse infrastructures. In order to meet the increasing need of up-to-date information, many messages are exchanged over time. The efficiency of those integration flows is therefore crucial to handle the high load of messages and to reduce message latency. State-of-the-art strategies to address this performance bottleneck are based on incremental statistic maintenance and periodic ...
Tópico(s): Scheduling and Optimization Algorithms
2014 - Elsevier BV | Information Systems
Michael P. Braun, Matthias Reinschmidt, Thomas Datzmann, David S. Waugh, Rafael Zamora, Annett Häbich, Luís Neves, Helga Gerlach, Thomas Arndt, Claudia Mettke‐Hofmann, Hedwig Sauer‐Gürth, Michaël Wink,
Abstract The Australasian region is a centre of biodiversity and endemism, mainly based on the tropical climate in combination with the large amount of islands. During the Pleistocene, islands of the Sahul Shelf (Australia, New Guinea, Aru Islands) had been part of the same land mass, while islands within the Wallacea (Lesser Sunda Islands, Moluccas, Sulawesi etc.) remained isolated. We investigated biogeographical avian diversification patterns of two species complexes across the Wallacea and the ...
Tópico(s): Wildlife Conservation and Criminology Analyses
2016 - De Gruyter Open | European Journal of Ecology
Matthias Böehm, Dirk Habich, Wolfgang Lehner, Uwe Wloka,
Due to the changing scope of data management towards the management of heterogeneous and distributed systems and applications, integration processes gain in importance. This is particularly true for those processes used as abstractions of workflow-based integration tasks; these are widely applied in practice. In such scenarios, a typical IT infrastructure comprises multiple integration systems with overlapping functionalities. The major problems in this area are high development effort, low portability ...
Tópico(s): Cloud Computing and Resource Management
2009 - Springer Science+Business Media | Lecture notes in business information processing
Matthias Böehm, Dirk Habich, Steffen Preißler, Wolfgang Lehner, Uwe Wloka,
The inefficiency of integration processes—as an abstraction of workflow-based integration tasks—is often reasoned by low resource utilization and significant waiting times for external systems. With the aim to overcome these problems, we proposed the concept of process vectorization. There, instance-based integration processes are transparently executed with the pipes-and-filters execution model. Here, the term vectorization is used in the sense of processing a sequence (vector) of messages by one ...
Tópico(s): Advanced Software Engineering Methodologies
2009 - Springer Science+Business Media | Lecture notes in computer science
Matthias Böehm, Dirk Habich, Steffen Preißler, Wolfgang Lehner, Uwe Wloka,
Tópico(s): Cloud Computing and Resource Management
2009 - Springer Science+Business Media | Lecture notes in business information processing
Thomas Kissinger, Benjamin Schlegel, Matthias Böehm, Dirk Habich, Wolfgang Lehner,
Growing memory capacities and the increasing number of cores on modern hardware enforces the design of new in-memory indexing structures that reduce the number of memory transfers and minimizes the need for locking to allow massive parallel access. However, most applications depend on hard durability constraints requiring a persistent medium like SSDs, which shorten the latency and throughput gap between main memory and hard disks. In this paper, we present our winning solution of the SIGMOD Programming ...
Tópico(s): Caching and Content Delivery
2012 - Association for Computing Machinery | ACM SIGMOD Record
Matthias Böehm, Dirk Habich, Wolfgang Lehner,
Tópico(s): Distributed and Parallel Computing Systems
2011 - Springer Science+Business Media | Lecture notes in business information processing
Hubert Kolb, Matthias von Herrath,
... 204) Google Scholar, Nikulina et al., 2004Nikulina M. Habich C. Flohé S.B. Scott F.W. Kolb ...
Tópico(s): Pancreatic function and diabetes
2016 - Cell Press | Cell Metabolism
Rainer Mußmann, Marcus Geese, Friedrich Harder, Simone Kegel, Uwe Andag, Alexander Lomow, Ulrike Burk, Daria Onichtchouk, Cord Dohrmann, Matthias Austen,
... Scopus (270) Google Scholar, 12Kloppel G. Lohr M. Habich K. Oberholzer M. Heitz P.U. Surv. Synth. ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2007 - Elsevier BV | Journal of Biological Chemistry
Annegret Habich, Janna M. Baumann, Christopher G. Schwarz, Scott A. Przybelski, Matteo Pardini, Francesco Calizzano, Anna Inguanzo, Ketil Oppedal, Frédéric Blanc, Afina W. Lemstra, Jakub Hort, Matthias Brendel, M.A. Ochoa-Figueroa, Valentina Garibotto, Milica G. Kramberger, Andrea Pilotto, Bradley F. Boeve, Dag Aarsland, Eric Westman, Thomas Dierks, Kejal Kantarci, Silvia Morbelli, Laura E. Jonkman, Daniel Ferreira,
Abstract Background Patterns of regional atrophy and hypometabolism have been observed in dementia with Lewy bodies (DLB). However, determinants of regional vulnerability to structural and functional neurodegeneration remain largely unexplored. First, we investigated the association between regional gene expression and grey matter volumes in probable DLB patients. Since hypometabolism presumably precedes overt brain atrophy, we additionally investigate the association between regional gene expression ...
2024 - Wiley | Alzheimer s & Dementia
Wolfgang Kemmler, Michael Fröhlich, O. Ludwig, Christoph Eifler, Jörg Berger, Florian Micke, Heinz Kleinöder, Bernd Wegener, Christoph Zinner, Frank C. Mooren, Marc Teschler, A. Filipovic, S A Muller, Kathleen England, J. Vatter, S. Authenrieth, Matthias Kohl, Simon von Stengel,
... Malnick et al., 2016), critical public media releases (Habich, 2015) and serious federal regulations (BMU, 2019(BMU, , ...
Tópico(s): Neurological disorders and treatments
2024 - Frontiers Media | Frontiers in Sports and Active Living