Madeleine Mellqvist Fässberg, Barbara Vanaelst, Mattias Jonson, Therese Rydberg Sterner, Felicia Ahlner, Hanna Wetterberg, Lina Rydén, Silke Kern, Robert Sigström, Anna Zettergren, Ingmar Skoog, Margda Wærn,
Abstract Aims The first aim of this study was to provide prevalence suicidal feelings over time (past week, past month, past year and lifetime) in a population-based sample of old to very old adults without dementia. Does prevalence change with rising age? The second aim was to examine the fluctuation of suicidal feelings over time. How does this coincide with depression status? Methods Data were derived from the Gothenburg H70 Birth Cohort Studies (the H70 studies) which are multidisciplinary longitudinal ...
Tópico(s): Mental Health Treatment and Access
2019 - Cambridge University Press | Epidemiology and Psychiatric Sciences
Mattias Jonson, Ingmar Skoog, Thomas Marlow, Madeleine Mellqvist Fässberg, Margda Wærn,
The role of anxiety in late-life suicidal behavior has received relatively little attention. The aim was to explore the association between anxiety symptoms and suicidal feelings in a population sample of 70-year-olds without dementia, and to test whether associations would be independent of depression.Face-to-face interviews (N = 560) were carried out by psychiatric nurses and past month symptoms were rated with the Comprehensive Psychopathological Rating Scale (CPRS). The Brief Scale for Anxiety (BSA) ...
Tópico(s): Bipolar Disorder and Treatment
2012 - Cambridge University Press | International Psychogeriatrics
Fredrik Odhammar, Eva Sundin, Mattias Jonson, Gunnar Carlberg,
This study was part of the Erica Process and Outcome Study. The aim was to investigate if children's global functioning improves after psychodynamic psychotherapy. Variables that may predict changes in global functioning were examined both statistically and qualitatively, for example, the child's age and gender; diagnosis and comorbidity; treatment variables. The sample consisted of 33 children (five to 10 years of age) who participated in psychodynamic psychotherapy with parallel work with parents. ...
Tópico(s): Educational and Psychological Assessments
2011 - Taylor & Francis | Journal of Child Psychotherapy
Ewa Johansson, Ingela Jonson, Mattias Bosaeus, Eva Jennische,
Antisecretory factor (AF) also named S5a/Rpn10 was originally identified through its capacity to inhibit intestinal hypersecretion and was later shown to be a component in the proteasome complex. AF is also a potent anti-inflammatory agent and can act as a neuromodulator. In this study we used yeast two-hybrid screens, with yeast strain PJ692A transformed with the bait vector pGBKT7 (AF aa 1-105) against yeast strain Y187 pretransformed with human brain or placenta cDNA libraries, to identify AF-binding ...
Tópico(s): Galectins and Cancer Biology
2007 - Elsevier BV | Regulatory Peptides
Ylva Stewénius, Ludmila Gorunova, Tord Jonson, Nina Larsson, Mattias Höglund, Nils Mandahl, Fredrik Mertens, Felix Mitelman, David Gisselsson,
Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution have been little explored. We show here that abnormally short telomeres lead to a wide spectrum of mitotic disturbances in colorectal cancer cell lines, including anaphase bridging, whole-chromosome lagging, and mitotic multipolarity. These abnormalities were found in both the presence and absence of microsatellite ...
Tópico(s): Telomeres, Telomerase, and Senescence
2005 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Mattias Jonson, Robert Sigström, Kimberly A. Van Orden, Madeleine Mellqvist Fässberg, Ingmar Skoog, Margda Wærn,
To investigate potential differences in the strength of associations between different levels of passive and active suicidal ideation and all-cause mortality in older adults.Prospective cohort study.Population-based samples of older adults in Gothenburg, Sweden.Older adults aged 79 and above who participated in any wave of the Gothenburg H70 Birth Cohort Studies or the Prospective Population Study of Women between 1986 and 2015 (n = 2,438; 1,737 women, 701 men; mean age 86.6).Most intense level of ...
Tópico(s): Aging and Gerontology Research
2022 - Elsevier BV | American Journal of Geriatric Psychiatry
Mattias Jonson, Robert Sigström, Khedidja Hedna, Therese Rydberg Sterner, Hanna Falk, Hanna Wetterberg, Madeleine Mellqvist Fässberg, Margda Wærn, Ingmar Skoog,
Abstract Background Octogenarians of today are better educated, and physically and cognitively healthier, than earlier born cohorts. Less is known about time trends in mental health in this age group. We aimed to study time trends in the prevalence of depression and psychotropic drug use among Swedish 85-year-olds. Methods We derived data from interviews with 85-year-olds in 1986–1987 ( N = 348), 2008–2010 ( N = 433) and 2015–17 ( N = 321). Depression diagnoses were made according to the Diagnostic and Statistical ...
Tópico(s): Aging and Gerontology Research
2021 - Cambridge University Press | Psychological Medicine
Mattias Jonson, Robert Sigström, Madeleine Mellqvist Fässberg, Hanna Wetterberg, Lina Rydén, Therese Rydberg Sterner, Khedidja Hedna, Ulrika Nilsson, Ingmar Skoog, Margda Wærn,
Older adults have high suicide rates. We investigated potential time trends in the prevalence of passive and active suicidal ideation in 85-year-olds. Further, we examined factors associated with such ideation in this age group.Population-based samples of 85-year-olds were interviewed in 1986 (N = 347), 2008 (N = 426) and 2015 (N = 320). Past-month passive/active suicidal ideation was evaluated with the Paykel questions.Reporting any type of passive or active suicidal ideation was less common in 2008 (7.3%, ...
Tópico(s): Employment and Welfare Studies
2021 - Elsevier BV | Journal of Affective Disorders
Patrik Andreasson, Mattias Höglund, Tord Jonson, A N Békássy, Felix Mitelman, Bertil Johansson,
Tópico(s): Genomic variations and chromosomal abnormalities
1998 - Springer Nature | Leukemia
Ryckie G. Wade, Gráinne Bourke, Justin C.R. Wormald, Joshua Totty, Guy Stanley, Andrew Lewandowski, Sandeep S. Rakhra, Matthew D. Gardiner, Randy Bindra, M. Sher, M. Thomas, S D J Morgan, Bing‐Fang Hwang, Walter Santucci, Phong Tran, Lisa M. Kopp, Vojtěch Kunc, Amre Hamdi, Philip Grieve, Sammy Al Mukhaizeem, Kevin Blake, Conor Cuggy, Raymond J. Dolan, E Downes, E Geary, Alpana Ghadge, Patricia Gorman, Mattias Jonson, Natalie Jumper, Sadie Kelly, L Leddy, M. McMahon, Ciaran McNamee, Preston R. Miller, Ben Murphy, L. O'Halloran, Kathryn O’Shea, Joshua Skeens, Susannah Staunton, F Timon, Jeffrey A. Woods, Umberto Cortinovis, Laura Sala, Valeria Zingarello, Mohd Hanifah Jusoh, Abdul Nawfar Sadagatullah, Gordana Georgieva, Sofija Pejkova, Bisera Nikolovska, Blagoja Srbov, Hytham K. S. Hamid, M. A. Mustafa, Mansour Abdelrahman, Shafin Amin, D Bhatti, K M A Rahman, Irfan Jumabhoy, John Kiely, Ingrid Kieran, Andre Lo, Kai Yuen Wong, Anthony Allan, H Armes, M D Horwitz, Lydia Ioannidi, G. Masterton, Howard Chu, Gautam Talawadekar, Kin Seng Tong, Matthew T.V. Chan, M Tredgett, Claire Hardie, E Powell-Smith, N. R. Gilham, M. I. Prokopenko, Raghib Ahmad, James Davies, Shiqi Zhen, Dallan Dargan, Richard Pinder, Michal Koziara, R. Russell Martin, Emma Reay, Elliott Cochrane, Amr Elbatawy, F Green, Timothy T. Griffiths, George Higginbotham, S Louette, Gordon McCauley, Ibrahim Natalwala, Emma Salt, Rashid Ahmed, Peter Goon, Robert Manton, N Segaren, Graham Cheung, M. R. Mahoney, Soumendu Sen, D Clarkson, M Collins, A. I. Bolt, Prashan Lokanathan, A.Y. Ng, G.M. Jones, J W M Jones, Rakan Kabariti, Sun Jung Rhee, J Herron, Alan Kay, L.K. Cheung, David G. Thomson, R S Jugdey, Hye Eun Yoon, Z L, J Southgate, Christie Brennan, Sahar Kiani, Mate Zabaglo, Zia Haider, Robert Poulter, Azizi Sheik‐Ali, A Watts, B. Jemec, Natalie Redgrave, Leanne Dupley, Michael Greenhalgh, John P. Vella, Holly Harris, Andrea Robinson, Simon Dupre, S Teelucksingh, A Gargan, S Hettiaratchy, Abhilash Jain, Richard M. Kwasnicki, A Lee, Mehul Thakkar, D Berwick, N Ismail, Maher A. Mahdi, Jeremy Rodrigues, Chee Yoong Liew, A Saadya, M Clarkson, C Brady, Roger Harrison, Anthony A. Rayner, G J Nolan, B. Phillips, N. Madhusudan,
Abstract Introduction Surgical site infection (SSI) is the most common and costly complication of surgery. International guidelines recommend topical alcoholic chlorhexidine (CHX) before surgery. However, upper limb surgeons continue to use other antiseptics, citing a lack of applicable evidence, and concerns related to open wounds and tourniquets. This study aimed to evaluate the safety and effectiveness of different topical antiseptics before upper limb surgery. Methods This international multicentre ...
Tópico(s): Wound Healing and Treatments
2021 - Wiley | BJS Open
Khedidja Hedna, Johan Fastbom, Mattias Jonson, Katarina Wilhelmson, Margda Wærn,
Abstract Objectives To investigate psychoactive medication use and risk of suicide in long‐term care facility (LTCF) residents aged 75 and above. A second aim was to investigate the role of psychiatric and medical conditions in the occurrence of suicide in LTCF residents. Methods A Swedish national register‐based cohort study of LTFC residents aged ≥75 years between 1 January 2008 and 31 December 2015, and followed until 31 December 2016 ( N = 288,305). Fine and Gray regression models were used to analyse ...
Tópico(s): Mental Health Treatment and Access
2022 - Wiley | International Journal of Geriatric Psychiatry
David Gisselsson, Tord Jonson, Åsa Petersén, Bodil Strömbeck, Paola Dal Cin, Mattias Höglund, Felix Mitelman, Fredrik Mertens, Nils Mandahl,
Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human tumors, chromosomal breakpoint profiles were constructed for 102 pancreatic carcinomas and 140 osteosarcomas, two tumor types characterized by extensive genomic instability. Cases with few chromosomal alterations showed a preferential clustering of breakpoints to the terminal bands, whereas tumors with ...
Tópico(s): Genomic variations and chromosomal abnormalities
2001 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Markus Heidenblad, Eric Schoenmakers, Tord Jonson, Ludmila Gorunova, Joris A. Veltman, Ad Geurts van Kessel, Mattias Höglund,
Abstract Pancreatic carcinomas display highly complex chromosomal abnormalities, including many structural and numerical aberrations. There is ample evidence indicating that some of these abnormalities, such as recurrent amplifications and homozygous deletions, contribute to tumorigenesis by altering expression levels of critical oncogenes and tumor suppressor genes. To increase the understanding of gene copy number changes in pancreatic carcinomas and to identify key amplification/deletion targets, ...
Tópico(s): Cancer Genomics and Diagnostics
2004 - American Association for Cancer Research | Cancer Research
Markus Heidenblad, Tord Jonson, Eija Mahlamäki, Ludmila Gorunova, Ritva Karhu, Bertil Johansson, Mattias Höglund,
Abstract Previous cytogenetic and comparative genomic hybridization (CGH) analyses have shown that the gain of chromosome arm 12p is frequent in pancreatic carcinomas. We investigated 15 pancreatic carcinoma cell lines using CGH, fluorescence in situ hybridization (FISH), and semiquantitative polymerase chain reaction (PCR) to characterize 12p amplifications in detail. The CGH analysis revealed gains of 12p in four of the cell lines and local amplification within 12p11–12 in six cell lines. By FISH ...
Tópico(s): Cancer Genomics and Diagnostics
2002 - Wiley | Genes Chromosomes and Cancer
Khedidja Hedna, Mattias Jonson, Robert Sigström, Anna Levinsson, Axel Nordenskjöld, Margda Wærn,
Electroconvulsive therapy (ECT) is effective in treating late-life depression. There is limited research on suicidal behavior and all-cause mortality in the oldest old after ECT.
Tópico(s): Cardiac Health and Mental Health
2024 - Wiley | International Journal of Geriatric Psychiatry
Mattias Höglund, Ludmila Gorunova, Tord Jonson, Sigmund Dawiskiba, Åke Andrén‐Sandberg, Göran Stenman, Bertil Johansson,
Chromosome 18 was analysed using a banding technique and fluorescence in situ hybridization (FISH) in 13 pancreatic carcinoma samples. The cytogenetic analysis revealed that chromosome 18 abnormalities were present in all cases and that several different rearrangements, such as translocations, deletions, dicentrics and ring chromosomes, were often found together. FISH mapping using 18q YAC probes showed that all tumours had lost at least one copy of 18q and that 18p was over-represented in 6 of the ...
Tópico(s): Cancer Genomics and Diagnostics
1998 - Springer Nature | British Journal of Cancer
Markus Heidenblad, David Lindgren, Joris A. Veltman, Tord Jonson, Eija Mahlamäki, Ludmila Gorunova, Ad Geurts van Kessel, Eric Schoenmakers, Mattias Höglund,
Tópico(s): Pancreatic and Hepatic Oncology Research
2005 - Springer Nature | Oncogene
Tord Jonson, Elin Albrechtsson, Jan Axelson, Markus Heidenblad, Ludmila Gorunova, B Johansson, Mattias Höglund,
Alteration of the transforming growth factor beta (TGFB) signalling pathway is important in pancreatic carcinogenesis, as shown by the frequent inactivation of the downstream target SMAD4. We recently analysed a series of pancreatic carcinoma cell lines with respect to alterations of five SMAD genes involved in TGFB signalling, and showed that SMAD4 was structurally rearranged in 42% of these. This pathway may, however, also be affected by alterations of genes whose products regulate the activation ...
Tópico(s): TGF-β signaling in diseases
2001 - Spandidos Publishing | International Journal of Oncology
Neil Price, Charlotte Hedenstierna‐Jonson, Torun Zachrisson, Anna Kjellström, Jan Storå, Maja Krzewińska, Torsten Günther, Verónica Sobrado, Mattias Jakobsson, Anders Götherström,
Abstract
Tópico(s): Medieval Literature and History
2019 - Cambridge University Press | Antiquity
Charlotte Hedenstierna‐Jonson, Anna Kjellström, Torun Zachrisson, Maja Krzewińska, Verónica Sobrado, Neil Price, Torsten Günther, Mattias Jakobsson, Anders Götherström, Jan Storå,
Abstract Objectives The objective of this study has been to confirm the sex and the affinity of an individual buried in a well‐furnished warrior grave (Bj 581) in the Viking Age town of Birka, Sweden. Previously, based on the material and historical records, the male sex has been associated with the gender of the warrior and such was the case with Bj 581. An earlier osteological classification of the individual as female was considered controversial in a historical and archaeological context. A genomic ...
Tópico(s): Forensic Anthropology and Bioarchaeology Studies
2017 - Wiley | American Journal of Physical Anthropology
Markus Heidenblad, David Lindgren, Tord Jonson, Fredrik Liedberg, Srinivas Veerla, Gunilla Chebil, Sigurður Guðjónsson, Åke Borg, Wiking Månsson, Mattias Höglund,
Abstract Background Urothelial carcinoma (UC) is characterized by nonrandom chromosomal aberrations, varying from one or a few changes in early-stage and low-grade tumors, to highly rearranged karyotypes in muscle-invasive lesions. Recent array-CGH analyses have shed further light on the genomic changes underlying the neoplastic development of UC, and have facilitated the molecular delineation amplified and deleted regions to the level of specific candidate genes. In the present investigation we ...
Tópico(s): Genetic factors in colorectal cancer
2008 - BioMed Central | BMC Medical Genomics
Ricardo Varela, Kristjan H. S. Moore, S. Sunna Ebenesersdóttir, Gülşah Merve Kılınç, Anna Kjellström, Ludvig Papmehl-Dufay, Clara Alfsdotter, Birgitta Berglund, Loey Alrawi, Natalija Kashuba, Verónica Sobrado, Vendela Kempe Lagerholm, Edmund Gilbert, Gianpiero L. Cavalleri, Eivind Hovig, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Thomas Hansen, Thomas Werge, Arielle R. Munters, Carolina Bernhardsson, Birgitte Skår, Axel Christophersen, Gordon Turner‐Walker, Shyam Gopalakrishnan, Eva Daskalaki, Ayça Omrak, Patxi Pérez-Ramallo, Pontus Skoglund, Linus Girdland-Flink, Gunnarsson Fredrik, Charlotte Hedenstierna‐Jonson, M. Thomas P. Gilbert, Kerstin Lidén, Mattias Jakobsson, Lars Einarsson, Helena Victor, Maja Krzewińska, Torun Zachrisson, Jan Storå, Kāri Stefánsson, Agnar Helgason, Anders Götherström,
We investigate a 2,000-year genetic transect through Scandinavia spanning the Iron Age to the present, based on 48 new and 249 published ancient genomes and genotypes from 16,638 modern individuals. We find regional variation in the timing and magnitude of gene flow from three sources: the eastern Baltic, the British-Irish Isles, and southern Europe. British-Irish ancestry was widespread in Scandinavia from the Viking period, whereas eastern Baltic ancestry is more localized to Gotland and central ...
Tópico(s): Genetic diversity and population structure
2023 - Cell Press | Cell
... 10.1386/infs_00027_1Neil Price, Charlotte Hedenstierna-Jonson, Torun Zachrisson, Anna Kjellström, Jan Storå, Maja Krzewińska, Torsten Günther, Verónica Sobrado, Mattias Jakobsson, Anders Götherström Viking warrior women? Reassessing Birka ...
Tópico(s): Public Spaces through Art
2001 - University of Chicago Press | Metropolitan Museum Journal
Rachel R. Phillips, Marc Friberg, Mattias Lantz Cronqvist, Carl‐Oscar Jonson, Erik Prytz,
A severe hemorrhage can result in death within minutes, before professional first responders have time to arrive. Thus, intervention by bystanders, who may lack medical training, may be necessary to save a victim’s life in situations with bleeding injuries. Proper intervention requires that bystanders accurately assess the severity of the injury and respond appropriately. As many bystanders lack tools and training, they are limited in terms of the information they can use in their evaluative process. ...
Tópico(s): Trauma and Emergency Care Studies
2020 - Public Library of Science | PLoS ONE
Tord Jonson, Markus Heidenblad, Petra Håkansson, Ludmila Gorunova, Bertil Johansson, Thoas Fioretos, Mattias Höglund,
Abstract Transforming growth factor beta‐1 (TGFB1)–induced gene expression was studied in five pancreatic carcinoma cell lines and one known TGFB1‐sensitive cell line (HaCaT) by use of high‐density filter‐based cDNA microarrays representing over 4,000 human genes. The results indicate a complex cellular response to TGFB1 with 10% of the investigated genes showing altered expression after 3 or 48 hr of TGFB1 exposure. The tumor cell lines displayed a gradually inversed gene expression pattern, which ...
Tópico(s): Hedgehog Signaling Pathway Studies
2003 - Wiley | Genes Chromosomes and Cancer
Yuesheng Jin, Ylva Stewénius, David Lindgren, Attila Frigyesi, O. Calcagnile, Tord Jonson, Anna Edqvist, Nina Larsson, Lena Maria Lundberg, Gunilla Chebil, Fredrik Liedberg, Sigurður Guðjónsson, Wiking Månsson, Mattias Höglund, David Gisselsson,
Abstract Purpose: Chromosomal instability (CIN) is believed to have an important role in the pathogenesis of urothelial cancer (UC). The aim of this study was to evaluate whether disturbances of mitotic segregation contribute to CIN in UC, if these processes have any effect on the course of disease, and how deregulation of these mechanisms affects tumor cell growth. Experimental Design: We developed molecular cytogenetic methods to classify mitotic segregation abnormalities in a panel of UC cell lines. ...
Tópico(s): Epigenetics and DNA Methylation
2007 - American Association for Cancer Research | Clinical Cancer Research
Tord Jonson, Ludmila Gorunova, Sigmund Dawiskiba, �ke Andr�n-Sandberg, G�ran Stenman, Peter ten Dijke, Bertil Johansson, Mattias H�glund,
SMAD4 (DPC4) is part of the TGFB signaling pathway and is frequently inactivated in pancreatic carcinomas. TGFB signals from the membrane to the nucleus via SMAD proteins. TGFB receptor activation results in SMAD2 and SMAD3 phosphorylation, which then form heteromeric complexes with SMAD4. Inhibitory SMADs, SMAD6 and SMAD7, can prevent TGFB signaling by interacting either with the receptor or with SMAD2 and SMAD3. The encoding sequences for these proteins are organized in two gene clusters, one at ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
1999 - Wiley | Genes Chromosomes and Cancer
Tord Jonson, Eija Mahlamäki, Ritva Karhu, Ludmila Gorunova, Bertil Johansson, Mattias Höglund,
Gene amplification is one of the mechanisms for oncogene activation in solid tumors. The size of the amplified regions may vary considerably among individual tumors, and more than one gene may be affected within the same amplicon. The main objective in analyzing genomic amplifications has therefore been to map the shortest region involved and to identify genes with increased expression as a result of the increased gene copy number. To facilitate such an analysis, we have developed simple polymerase ...
Tópico(s): Cancer Genomics and Diagnostics
2000 - Wiley | Genes Chromosomes and Cancer
Maja Krzewińska, Anna Kjellström, Torsten Günther, Charlotte Hedenstierna‐Jonson, Torun Zachrisson, Ayça Omrak, Reyhan Yaka, Gülşah Merve Kılınç, Mehmet Somel, Verónica Sobrado, Jane Evans, Corina Knipper, Mattias Jakobsson, Jan Storå, Anders Götherström,
The impact of human mobility on the northern European urban populations during the Viking and Early Middle Ages and its repercussions in Scandinavia itself are still largely unexplored. Our study of the demographics in the final phase of the Viking era is the first comprehensive multidisciplinary investigation that includes genetics, isotopes, archaeology, and osteology on a larger scale. This early Christian dataset is particularly important as the earlier common pagan burial tradition during the ...
Tópico(s): Genetic diversity and population structure
2018 - Elsevier BV | Current Biology
Bernadette Lamb, Jonathan Herskovitz, Mattias Jonson, Harlan Sayles, Faruq Pradhan,
Tópico(s): Nutrition, Genetics, and Disease
2024 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology