Steven W. Hutcheson, Haitao Zhang, Maxim Suvorov,
Saccharophagus degradans 2-40 is a γ-subgroup proteobacterium capable of using many of the complex polysaccharides found in the marine environment for growth. To utilize these complex polysaccharides, this bacterium produces a plethora of carbohydrases dedicated to the processing of a carbohydrate class. Aiding in the identification of the contributing genes and enzymes is the known genome sequence for this bacterium. This review catalogs the genes and enzymes of the S. degradans genome that are ...
Tópico(s): Enzyme Production and Characterization
2011 - Multidisciplinary Digital Publishing Institute | Marine Drugs
Maxim Suvorov, Rajeev Kumar, Haitao Zhang, Steven W. Hutcheson,
The saprophytic marine bacterium Saccharophagus degradans is capable of degrading whole plant material by releasing sugars through the coordinated expression of carbohydrases. The genome sequence of this bacterium indicates the presence of complex carbohydrase systems whose biochemical activities and regulation are being explored. This review summarizes the novelties of these carbohydrase systems that are most applicable to biofuel production. Multi-enzyme systems were shown to be expressed by this ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2010 - Taylor & Francis | Biofuels
Maxim Suvorov, Mijoon Lee, Dušan Hesek, Bill Boggess, Shahriar Mobashery,
The cell wall is an indispensable structure for the survival of bacteria and a target for antibiotics. Peptidoglycan is the major constituent of the cell wall, which is comprised of backbone repeats of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM). A peptide stem is appended to the NAM unit, which in turn experiences cross-linking with a peptide from another peptidoglycan in the final steps of cell wall assembly. In the normal course of bacterial growth, as much as 60% of the parental cell ...
Tópico(s): Enzyme Structure and Function
2008 - American Chemical Society | Journal of the American Chemical Society
Cosimo Fuda, Maxim Suvorov, Qicun Shi, Dušan Hesek, Mijoon Lee, Shahriar Mobashery,
The genome of Staphylococcus aureus is constantly in a state of flux, acquiring genes that enable the bacterium to maintain resistance in the face of antibiotic pressure. The acquisition of the mecA gene from an unknown origin imparted S. aureus with broad resistance to β-lactam antibiotics, with the resultant strain designated as methicillin-resistant S. aureus (MRSA). Epidemiological and genetic evidence suggests that the gene encoding PBP 2a of MRSA might have originated from Staphylococcus sciuri, ...
Tópico(s): Bacterial biofilms and quorum sensing
2007 - American Chemical Society | Biochemistry
Cosimo Fuda, Maxim Suvorov, Sergei B. Vakulenko, Shahriar Mobashery,
Penicillin-binding protein 2a (PBP2a) of Staphylococcus aureus is refractory to inhibition by available β-lactam antibiotics, resulting in resistance to these antibiotics. The strains of S. aureus that have acquired the mecA gene for PBP2a are designated as methicillin-resistant S . aureus (MRSA). The mecA gene was cloned and expressed in Escherichia coli , and PBP2a was purified to homogeneity. The kinetic parameters for interactions of several β-lactam antibiotics (penicillins, cephalosporins, and a ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2004 - Elsevier BV | Journal of Biological Chemistry
Dušan Hesek, Maxim Suvorov, Ken‐ichiro Morio, Mijoon Lee, Stephen H.M. Brown, Sergei B. Vakulenko, Shahriar Mobashery,
The major constituent of the bacterial cell wall, peptidoglycan, is comprised of repeating units of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) with an appended peptide. Penicillin-binding proteins (PBPs) are involved in the final stages of bacterial cell wall assembly. Two activities for PBPs are the cross-linking of the cell wall, carried out by dd-transpeptidases, and the dd-peptidase activity, that removes the terminal d-Ala residue from peptidoglycan. The dd-peptidase activity moderates ...
Tópico(s): Pneumonia and Respiratory Infections
2004 - American Chemical Society | The Journal of Organic Chemistry
Mijoon Lee, Dušan Hesek, Maxim Suvorov, Wenlin Lee, Sergei B. Vakulenko, Shahriar Mobashery,
Penicillin-binding proteins (PBPs) are responsible for the final stages of bacterial cell wall assembly. These enzymes are targets of beta-lactam antibiotics. Two of the PBP activities include dd-transpeptidase and DD-carboxypeptidase activities, which carry out the cross-linking of the cell wall and trimming of the peptidoglycan, the major constituent of the cell wall, by an amino acid, respectively. The activity of the latter enzyme moderates the degree of cross-linking of the cell wall, which ...
Tópico(s): Peptidase Inhibition and Analysis
2003 - American Chemical Society | Journal of the American Chemical Society
Sergei B. Vakulenko, Dasantila Golemi, Bruce Geryk, Maxim Suvorov, James R. Knox, Shahriar Mobashery, Stephen A. Lerner,
ABSTRACT The class C β-lactamase from Enterobacter cloacae P99 confers resistance to a wide range of broad-spectrum β-lactams but not to the newer cephalosporin cefepime. Using PCR mutagenesis of the E. cloacae P99 ampC gene, we obtained a Leu-293-Pro mutant of the P99 β-lactamase conferring a higher MIC of cefepime (MIC, 8 μg/ml, compared with 0.5 μg/ml conferred by the wild-type enzyme). In addition, the mutant enzyme produced higher resistance to ceftazidime but not to the other β-lactams tested. ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2002 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Haitao Zhang, Young Hwan Moon, Brian J. Watson, Maxim Suvorov, Elizabeth Cristina Gomes dos Santos, Corinn Sinnott, Steven W. Hutcheson,
Saccharophagus degradans 2-40 is a marine gamma proteobacterium that can produce polyhydroxyalkanoates from lignocellulosic biomass using a complex cellulolytic system. This bacterium has been annotated to express three surface-associated β-glucosidases (Bgl3C, Ced3A, and Ced3B), two cytoplasmic β-glucosidases (Bgl1A and Bgl1B), and unusual for an aerobic bacterium, two cytoplasmic cellobiose/cellodextrin phosphorylases (Cep94A and Cep94B). Expression of the genes for each of the above enzymes was ...
Tópico(s): Enzyme Production and Characterization
2011 - Springer Science+Business Media | Journal of Industrial Microbiology & Biotechnology
Maxim Suvorov, Sergei B. Vakulenko, Shahriar Mobashery,
ABSTRACT Bacterial β-lactamases are the major causes of resistance to β-lactam antibiotics. Three classes of these enzymes are believed to have evolved from ancestral penicillin-binding proteins (PBPs), enzymes responsible for bacterial cell wall biosynthesis. Both β-lactamases and PBPs are able to efficiently form acyl-enzyme species with β-lactam antibiotics. In contrast to β-lactamases, PBPs are unable to efficiently turn over antibiotics and therefore are susceptible to inhibition by β-lactam ...
Tópico(s): Plant Pathogenic Bacteria Studies
2007 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Demkin Vv, Mikhail V. Edelstein, Andrey L. Zimin, Inna A. Edelstein, Maxim Suvorov,
A simple technique providing a means for rapid genetic differentiation of chlamydial strains is described. The technique is based on a single-step sequence-specific separation of PCR-amplified DNA fragments by electrophoresis in an agarose gel containing a DNA ligand - bisbenzimide-PEG. A hypervariable region at the 5' end of the omp2 gene of Chlamydiaceae species encoding the 60-kDa cysteine-rich outer membrane protein was selected as a target for PCR. The appropriate fragments were amplified from ...
Tópico(s): Gout, Hyperuricemia, Uric Acid
2000 - Oxford University Press | FEMS Microbiology Letters
D.S. Klygach, M.G. Vakhitov, P.V. Suvorov, Д. А. Жеребцов, С. В. Труханов, Аrtem L. Kozlovskiy, Maxim V. Zdorovets, А. В. Труханов,
Static magnetic properties (field dependences of the magnetization and the complex permeability) in the wide temperature range were investigated. The electrodynamic properties of powdered carbonyl iron in the Extremely High Frequency range – 30–50 GHz were studied. The permittivity and the permeability of the material and dielectric and magnetic loss tangents were measured. The losses in the material layer were calculated. Negative values of the permittivity and the permeability are explained in terms ...
Tópico(s): Electromagnetic wave absorption materials
2019 - Elsevier BV | Journal of Magnetism and Magnetic Materials
Maxim M. Trubyanov, Г. М. Мочалов, Sergey S. Suvorov, Egor S. Puzanov, Anton N. Petukhov, И. В. Воротынцев, В. М. Воротынцев,
Tópico(s): Spectroscopy and Laser Applications
2018 - Elsevier BV | Journal of Chromatography A
Maxim M. Trubyanov, Г. М. Мочалов, В. М. Воротынцев, Sergey S. Suvorov,
The paper deals with the effect of operating conditions on small-scale randomly-packed column separation performance during distillation of high-purity liquefied gases under elevated pressure (up to 25 × 105 Pa). Examination of mass-transfer performance under elevated pressure at a fixed distance from flood has been made for high-performance spiral-prismatic packings of 4 mm and 2 mm nominal size using silane- and ammonia-based test systems. Impact of simultaneously changing pressure, temperature and ...
Tópico(s): Field-Flow Fractionation Techniques
2014 - Elsevier BV | Separation and Purification Technology
Vladimir Valentinovich Kozhevnikov, S. A. Khartov, Maxim Suvorov, Ivan Cherniy,
This paper presents the results of plasma parameters probe studies in the discharge chamber of low power laboratory ion thruster. The measurement procedure based on the use of triple Langmuir probe placed into the discharge chamber's plasma. During the plasma measurements probe characteristics were collected automatically by data acquisition software created in LabVIEW development environment. In the current paper we discuss the results of the experiment: electron temperature Te distribution and ...
Tópico(s): Particle accelerators and beam dynamics
2017 - Elsevier BV | Procedia Engineering
Maxim M. Trubyanov, Г. М. Мочалов, И. В. Воротынцев, Andrey V. Vorotyntsev, Sergey S. Suvorov, Konstantin Y. Smirnov, В. М. Воротынцев,
A novel method for rapid, quantitative determination of trace permanent gases and carbon dioxide in ultra-high purity ammonia by dual-channel two-dimensional GC-PDHID is presented. An improved matrix back-flush-to-vent approach combining back-flush column switching technique with auxiliary NaHSO4 ammonia trap is described. The NaHSO4 trap prevents traces of ammonia from entering the analytical column and is shown not to affect the impurity content of the sample. The approach allows shortening the ...
Tópico(s): Gas Sensing Nanomaterials and Sensors
2016 - Elsevier BV | Journal of Chromatography A
Viacheslav Meshcherinov, Viktor Kazakov, Maxim Spiridonov, Gennady Suvorov, A. V. Rodin,
Tópico(s): Atmospheric chemistry and aerosols
2024 - Elsevier BV | Sensors and Actuators B Chemical
Maxim M. Trubyanov, Г. М. Мочалов, В. М. Воротынцев, Sergey S. Suvorov,
Tópico(s): Advanced Control Systems Optimization
2013 - Pleiades Publishing | Russian Journal of Applied Chemistry
Alexey Noev, Kovalenko Sandaara, E. D. Gataulina, E.A. Turchaninova, V.D. Dzhabrailov, Aleria A. Aitova, Daria Likhobabina, Janna Sutemieva, Sheida Frolova, Lars Ruppel, D. A. Minakov, Nikita Suvorov, Petr Ostroverkhov, Yu.L. Vasil’ev, Maxim V. Nikolaev, V.А. Tsvelaya, Konstantin Agladze, Mikhail A. Grin,
The work is devoted to the synthesis of new light-controlled voltage-gated sodium (Nav) channel blockers based on azobenzene and the study of their local anesthetic and antiarrhythmic properties. The effect of ethercaine and two of its new derivatives on native Nav channels was studied in vitro using the patch-clamp method on isolated excitable cells (neurons and cardiomyocytes) of a rat, and local anesthetic activity of the compounds was evaluated on rabbit’s eye cornea. Studies of the effect of ...
Tópico(s): Neuroscience and Neuropharmacology Research
2004 - MAIK Nauka/Interperiodica | Биофизика
Gennady V. Kretinin, Maxim E. Megem,
The article examines the administrative activities of General-Lieutenant Vasily I. Suvorov during the Seven Years’ War of 1756-1763 in connection with supply of the Russian army with provision and other types of allowances. Particular attention is paid to his administration of the province of Prussia in 1761, relations with the local population, and assistance to the Prussians in eliminating the consequences of flood.
Tópico(s): Central European and Russian historical studies
2021 - Russian Academy of Sciences | OOO Zhurnal Voprosy Istorii
Mikhail A. Grin, Petr Ostroverkhov, Nikita Suvorov, Sergey Tikhonov, Alexander Popov, Anastasia Shelyagina, Nikita Kirin, A.I. Nichugovskiy, Maxim Usachev, Natalia Bragina, Е. А. Плотникова, A. L. Pankratov,
Combined therapy is currently a popular method for increasing the efficiency of antitumor treatment. It involves the use of two different tumor treatment methods, namely, chemotherapy and PDT. Combining a cytotoxic agent and a photosensitizer in a single molecule results in a synergistic antitumor effect that overcomes the multiple drug resistance and reduces the therapeutic drug doses. In this work, pyridine-containing natural chlorins were obtained by introducing a pyridine group into 13 1 -[Formula: ...
Tópico(s): Metal complexes synthesis and properties
2023 - World Scientific | Journal of Porphyrins and Phthalocyanines
Rui Lou, Oleksandr Suvorov, H.‐J. Grafe, Andrii Kuibarov, Maxim Krivenkov, O. Rader, B. Büchner, С. В. Борисенко, А.А. Федоров,
The nematicity in multilayer $\mathrm{FeSe}/{\mathrm{SrTiO}}_{3}$ films has been previously suggested to be enhanced with decreasing film thickness. Motivated by this, there have been many discussions about the competing relation between nematicity and superconductivity. However, the criterion for determining the nematicity strength in FeSe remains highly debated. The understanding of nematicity as well as its relation to superconductivity in FeSe films is therefore still controversial. Here, we fabricate ...
Tópico(s): Corporate Taxation and Avoidance
2023 - American Physical Society | Physical Review Research
K. Abe, P. Adrich, H. Aihara, R. Akutsu, I. Yu. Alekseev, A. Ali, F. Ameli, I. M. Anghel, L. H. V. Anthony, M. Antonova, A. Araya, Y. Asaoka, Yosuke Ashida, V. Aushev, F. Ballester, I. Bandac, M. Barbi, Gareth J. Barker, G. Barr, M. Batkiewicz, M. Bellato, V. Berardi, M. Bergevin, L. Bernard, E. Bernardini, L. Berns, S. Bhadra, J. M. Bian, Adrien Blanchet, F. d. M. Blaszczyk, A. Blondel, A. Boiano, S. Bolognesi, L. Bonavera, N. Booth, S. Borjabad, T. Boschi, D. Bose, S. B. Boyd, C. Bozza, A. Bravar, D. Bravo, C. Bronner, Louise Brown, A. Bubak, A. Buchowicz, M. Buizza Avanzini, F. Cafagna, N. F. Calabria, J. M. Calvo-Mozota, S. Cao, S. L. Cartwright, A. Carroll, M. G. Catanesi, S. Cebrián, Mariusz Chabera, S. Chakraborty, C. Checchia, J. H. Choi, Sandhya Choubey, M. Cicerchia, J. P. Coleman, G. Collazuol, L. Cook, G. Cowan, S. Cuen-Rochin, M. Danilov, G. Lopez, E. De la Fuente, P. de Perio, G. De Rosa, T. Dealtry, Chris Densham, A. Dergacheva, N. Deshmukh, Moon Moon Devi, F. Di Lodovico, P. Di Meo, I. Di Palma, T. A. Doyle, E. Drakopoulou, O. Drapier, J. Dumarchez, P. Dunne, M. Dziewiecki, L. Eklund, S. El Hedri, John Ellis, S. Emery, A. Esmaili, R. Esteve, A. Evangelisti, M. Feely, S. Fedotov, J. Feng, P. Fernández, E. Fernández-Martínez, P. Ferrario, B. Ferrazzi, T. Feusels, A.J. Finch, C. Finley, A. Fiorentini, G. Fiorillo, M. Fitton, K. Frankiewicz, M. Friend, Y. Fujii, Y. Fukuda, G. Galiński, J. Gao, C. S. Garde, A. Garfagnini, S. Garode, L. Gialanella, C. Giganti, J.J. Gómez-Cadenas, M. Gonin, J. González-Nuevo, A. Gorin, R. Gornea, V. Gousy-Leblanc, F. Gramegna, M. Grassi, G. Grella, M. Guigue, P. Gumplinger, D. R. Hadley, Masayuki Harada, B. L. Hartfiel, M. Hartz, S. Hassani, N. C. Hastings, Y. Hayato, J. A. Hernando Morata, V. Herrero, J. Hill, K. Hiraide, S. Hirota, A. Holin, Shunsaku Horiuchi, K. Hoshina, K. Hultqvist, F. Iacob, A. K. Ichikawa, W. Idrissi Ibnsalih, T Iijima, M. Ikeda, M. Inomoto, K. Inoue, J. Insler, Ara Ioannisian, Toru Ishida, K. Ishidoshiro, H. Ishino, M. Ishitsuka, Hiroshi Itô, S. Ito, Y. Itow, K. Iwamoto, A. Izmaylov, N. Izumi, S. Izumiyama, M. Jakkapu, B. Jamieson, H. I. Jang, J. S. Jang, S. J. Jenkins, S. H. Jeon, M. Jiang, H. S. Jo, P. Jonsson, K. K. Joo, T. Kajita, H. Kakuno, J. Kameda, Y. Kano, P. Kalaczyński, D. Karlen, J. Kasperek, Y. Kataoka, A. Kato, T. Katori, Narine Kazarian, E. Kearns, M. Khabibullin, A. Khotjantsev, T. Kikawa, M. Kekic, J. H. Kim, J. Y. Kim, S. B. Kim, Stefan Y. Kim, S. King, T. Kinoshita, J. Kisiel, A. Klekotko, T. Kobayashi, L. Koch, M. Koga, L. Koerich, Nikolay Ivanov Kolev, A. Konaka, L. L. Kormos, Y. Koshio, A. Korzenev, Y. Kotsar, Konstantin Kouzakov, K. Kowalik, L. Kravchuk, A. P. Kryukov, Y. Kudenko, T. Kumita, R. Kurjata, T. Kutter, M. Kuze, Kyujin Kwak, M. La Commara, L. Labarga, J. Łagoda, M. Lamers James, M. Lamoureux, M. Laveder, Luigi Lavitola, M. Lawe, J. G. Learned, J. Lee, R. Leitner, V. Lezaun, I. T. Lim, T. Lindner, R. P. Litchfield, K. Long, A. Longhin, P.F. Loverre, X.-G. Lu, L. Ludovici, Y. Maekawa, L. Magaletti, K. Magar, K. Mahn, Y. Makida, M. Malek, Michal Malinský, T. Marchi, L. Maret, C. Mariani, A. Marinelli, K. Martens, Ll. Marti, J. F. Martin, D. Martin, J. Marzec, T. Matsubara, R. Matsumoto, S. Matsuno, M. Matusiak, E. Mazzucato, M. McCarthy, N. McCauley, J. McElwee, C. McGrew, A. Mefodiev, Abinash Medhi, P. Mehta, Lucile Mellet, H. Menjo, P. Mermod, C. Metelko, M. Mezzetto, J. Migenda, P. Migliozzi, P. Mijakowski, S. Miki, E. W. Miller, H. Minakata, A. Minamino, S. Mine, O. Mineev, Ayan Mitra, M. Miura, R. Moharana, C.M. Mollo, T. Mondal, M. Mongelli, F. Monrabal, D. H. Moon, C. S. Moon, Francisco Mora, S. Moriyama, Th. A. Mueller, L. Munteanu, Kohta Murase, Y. Nagao, T. Nakadaira, K. Nakagiri,
Abstract Core-collapse supernovae are among the most magnificent events in the observable universe. They produce many of the chemical elements necessary for life to exist and their remnants—neutron stars and black holes—are interesting astrophysical objects in their own right. However, despite millennia of observations and almost a century of astrophysical study, the explosion mechanism of core-collapse supernovae is not yet well understood. Hyper-Kamiokande is a next-generation neutrino detector ...
IOP Publishing
Е. А. Плотникова, Е. Р. Немцова, Maxim A. Abakumov, Nikita Suvorov, А. А. Панкратов, Peter Shegai, А. Д. Каприн,
This research presents a novel synthetic photosensitizer for the photodynamic therapy (PDT) of malignant tumors: meso-tetra(3-pyridyl) bacteriochlorin, which absorbs at 747 nm (in the long-wavelength region of the spectrum) and is stable when stored in the dark. H2Py4BC demonstrates pronounced photoinduced activity in vitro against tumor cells of various geneses (IC50 varies from 21 to 68 nM for HEp2, EJ, S37, CT26, and LLC cultured cells) and in vivo provides pronounced antitumor efficacy in the treatment ...
Tópico(s): Cancer Research and Treatments
2023 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Alexey Noev, S.G. Kovalenko, E. D. Gataulina, E.A. Turchaninova, V.D. Dzhabrailov, A.A. Aitova, Daria Likhobabina, Janna Sutemieva, Sheida Frolova, Lars Ruppel, D. A. Minakov, Nikita Suvorov, Petr Ostroverkhov, Yu.L. Vasil’ev, Maxim V. Nikolaev, V.А. Tsvelaya, Konstantin Agladze, Mikhail A. Grin,
Tópico(s): Neuroscience and Neuropharmacology Research
2024 - Pleiades Publishing | BIOPHYSICS
Alexander Popov, Nikita Suvorov, M. S. Larkina, Evgenii Plotnikov, Ruslan Varvashenya, Vitalina Bodenko, Gleb Yanovich, Petr Ostroverkhov, Maxim Usachev, Е. В. Филоненко, М. В. Белоусов, Mikhail A. Grin,
The use of radiopharmaceuticals for diagnostics in oncology allows for the detection of the disease at an early stage. Among diagnostic radionuclides,
Tópico(s): Inorganic Fluorides and Related Compounds
2024 - Multidisciplinary Digital Publishing Institute | Molecules
Lyudmila SUKHORUKOVA, николай ФОКИН, Maxim IVCHENKO, Tatiana SHESTAKOVA, Aleksandra Shestakova,
... programs` professional and pedagogical design for heads of Suvorov schools, Cadet Corps and universities. The method of ...
Tópico(s): Regional Economic Development and Innovation
2022 - | IJASOS- International E-journal of Advances in Social Sciences