Éric Villeneuve, Abdallah Samad, C. Volat, Mathieu Béland, Maxime Lapalme,
A scaled version of the APT70 drone rotor, typical of small to medium UAV rotors, was tested in a 9-meter-high cold chamber for a wide range of icing parameters. The drone rotor used has four blades with varying chord and twist settings. The objective of this study was to investigate icing effects on the rotor aerodynamic performance, based on experimental data, for varying rotor speeds, precipitation rates, droplet sizes and air temperatures. Aerodynamic loads were measured using the built-in load ...
Tópico(s): Cryospheric studies and observations
2022 - Multidisciplinary Digital Publishing Institute | Drones
Éric Villeneuve, Abdallah Samad, C. Volat, Mathieu Béland, Maxime Lapalme,
The icing facilities of the Anti-Icing Materials International Laboratory AMIL have been adapted to reproduce icing conditions on a Bell APT70 drone rotor, typical of small-to-medium UAV models. As part of an extensive icing test campaign, this paper presents the design and preliminary testing of the experimental setup and representative icing conditions calibration in the laboratory’s cold chamber. The drone rotor used has four blades with a diameter of 0.66 m and a maximum tip speed of 208 m/s. ...
Tópico(s): Aerospace Engineering and Energy Systems
2022 - Multidisciplinary Digital Publishing Institute | Drones
Sébastien P. Faucher, Chantal Forest, Maxime Béland, France Daigle,
Salmonella enterica serovar Typhi causes a human-restricted systemic infection called typhoid fever. We have identified a Typhi genomic region encoding two ORFs, STY1498 and STY1499, that are expressed during infection of human macrophages and organized in an operon. STY1498 corresponds to clyA , which encodes a pore-forming cytolysin, and STY1499 encodes a 27 kDa protein, without any attributed function, which we have named TaiA (Typhi-associated invasin A). In order to evaluate the roles of these ...
Tópico(s): Vibrio bacteria research studies
2009 - Microbiology Society | Microbiology
Katherine Poirier, Sébastien P. Faucher, Maxime Béland, Roland Brousseau, Victor P. J. Gannon, Christine Martin, Josée Harel, France Daigle,
Escherichia coli O157:H7 is an important food-borne pathogen that specifically binds to the follicle-associated epithelium in the intestine, which rapidly brings this bacterial pathogen in contact with underlying human macrophages. Very little information is available about the interaction between E. coli O157:H7 and human macrophages. We evaluated the uptake and survival of strain EDL933 during infection of human macrophages. Surprisingly, EDL933 survived and multiplied in human macrophages at ...
Tópico(s): Gut microbiota and health
2008 - American Society for Microbiology | Infection and Immunity
Julie Lamontagne, Maxime Béland, Anik Forest, Alexandra Côté-Martin, Najib Nassif, Fadi Tomaki, Ignacio Moriyón, Edgardo Moreno, Eustache Paramithiotis,
Brucellosis is a major bacterial zoonosis affecting domestic livestock and wild mammals, as well as humans around the globe. While conducting proteomics studies to better understand Brucella abortus virulence, we consolidated the proteomic data collected and compared it to publically available genomic data.The proteomic data was compiled from several independent comparative studies of Brucella abortus that used either outer membrane blebs, cytosols, or whole bacteria grown in media, as well as intracellular ...
Tópico(s): Salmonella and Campylobacter epidemiology
2010 - BioMed Central | BMC Genomics
The physiological function of the prion protein (PrP(C) ) and its conversion into its infectious form (PrP(Sc) ) are central issues to understanding the pathogenesis of prion diseases. The N-terminal moiety of PrP(C) (NH(2) -PrP(C) ) is an unstructured region with the characteristic of interacting with a broad range of partners. These interactions endow PrP(C) with multifunctional and sometimes contrasting capabilities, including neuroprotection and neurotoxicity. Recently, binding of β-sheet rich conformers ...
Tópico(s): Trace Elements in Health
2011 - Wiley | Journal of Neurochemistry
Maxime Béland, Julie Motard, Alice Barbarin, Xavier Roucou,
An endoproteolytic cleavage termed α-cleavage between residues 111/112 is a characteristic feature of the cellular prion protein (PrP C ). This cleavage generates a soluble N-terminal fragment (PrPN1) and a glycosylphosphatidylinositol-anchored C-terminal fragment (PrPC1). Independent studies demonstrate that modulating PrP C α-cleavage represents a potential therapeutic strategy in prion diseases. The regulation of PrP C α-cleavage is unclear. The only known domain that is essential for the α-cleavage ...
Tópico(s): Trace Elements in Health
2012 - Society for Neuroscience | Journal of Neuroscience
Maxime Béland, Mikaël Bédard, Guillaume Tremblay, Pierre Lavigne, Xavier Roucou,
Plasma membrane cellular prion protein (PrP(C)) is a high-affinity receptor for toxic soluble amyloid-β (Aβ) oligomers that mediates synaptic dysfunction. Secreted forms of PrP(C) resulting from PrP(C) α-cleavage (PrPN1) or shedding (shed PrP(C)) display neuroprotective activity in neuronal cultures and in mouse models of Aβ-induced neuronal dysfunction. In vitro, recombinant PrPN1 and PrP inhibit Aβ fibrillization. However, the mechanism by which PrPN1 and shed PrP(C) neutralize Aβ oligomers is unclear, ...
Tópico(s): Trace Elements in Health
2014 - Elsevier BV | Neurobiology of Aging
Prion and Alzheimer diseases are fatal neurodegenerative diseases caused by misfolding and aggregation of the cellular prion protein (PrP(C)) and the β-amyloid peptide, respectively. Soluble oligomeric species rather than large aggregates are now believed to be neurotoxic. PrP(C) undergoes three proteolytic cleavages as part of its natural life cycle, α-cleavage, β-cleavage, and ectodomain shedding. Recent evidences demonstrate that the resulting secreted PrP(C) molecules might represent natural ...
Tópico(s): Neurological diseases and metabolism
2013 - Landes Bioscience | Prion
Abdallah Samad, Éric Villeneuve, C. Volat, Mathieu Béland, Maxime Lapalme,
Drones and UAVs are gaining worldwide popularity and are now considered a popular choice for both military and commercial applications. Icing poses tremendous safety and performance concerns for the operation of all types of drones. This paper is part of a project that studies icing effects on the hovering 0.66 m diameter Bell APT70 drone rotor and the development of potential ice protection systems. The objective of this paper is to investigate the use of electrothermal heaters with severe icing ...
Tópico(s): Aerospace Engineering and Energy Systems
2023 - Elsevier BV | Experimental Thermal and Fluid Science
Éric Villeneuve, Abdallah Samad, C. Volat, Mathieu Béland, Maxime Lapalme,
A new installation at the Anti-Icing Materials International Laboratory was developed to study the effects of icing on the degradation of a hovering drone rotor aerodynamic performance and to test different potential ice protection solutions. Following a study on icing parameters effects on aerodynamic performance, this paper studies a methodology developed to assess the performances of coatings as a potential ice protection system under severe icing conditions and rotor speeds up to 4950 RPM. Four ...
Tópico(s): Surface Modification and Superhydrophobicity
2023 - Elsevier BV | Cold Regions Science and Technology
Valerica Pandarus, Rosaria Ciriminna, François Béland, Geneviève Gingras, Maxime Drobot, Omar Jina, Mario Pagliaro,
Simple flow chemistry technology coupled to newly developed solid organosilica catalysts can be successfully applied to enhance the efficiency and selectivity of two representative homogeneous syntheses widely employed by chemical companies. The method is general and can be extended to many other reactions using similar solid catalysts to afford reactions that are faster and cleaner than conventional homogeneous and heterogeneous conversions.
Tópico(s): Nanomaterials for catalytic reactions
2012 - Elsevier BV | Tetrahedron Letters
PrPC is associated with a variety of functions, and its ability to interact with a multitude of partners, including itself, may largely explain PrP multifunctionality and the lack of consensus on the genuine physiological function of the protein in vivo. In contrast, there is a consensus in the literature that alterations in PrPC trafficking and intracellular retention result in neuronal degeneration. In addition, a proteolytic modification in the late secretory pathway termed the α-cleavage induces ...
Tópico(s): Alzheimer's disease research and treatments
2013 - Landes Bioscience | Prion
Maxwell E. R. Shafer, Alana H.T. Nguyen, Mathieu Tremblay, Sophie Viala, Mélanie Béland, Nicholas Bertos, Morag Park, Maxime Bouchard,
During prostate development, basal and luminal cell lineages are generated through symmetric and asymmetric divisions of bipotent basal cells. However, the extent to which spindle orientation controls division symmetry or cell fate, and the upstream factors regulating this process, are still elusive. We report that GATA3 is expressed in both prostate basal progenitor and luminal cells and that loss of GATA3 leads to a mislocalization of PRKCZ, resulting in mitotic spindle randomization during progenitor ...
Tópico(s): Urological Disorders and Treatments
2017 - Elsevier BV | Stem Cell Reports
Kimberley J. Smith, Geneviève Gariépy, Maxime Pedneault, Mélanie Béland, Matthew Clyde, Norbert Schmitz,
There is an increasing interest in single-item self-rated indicators of perceived health and control status in people with chronic illnesses such as diabetes. However, self-rated measures can be associated with indicators of psychological status. The aim of this paper is to explore the association of anxiety, depression, and diabetes distress with self-rated diabetes control. Telephone interviews were conducted with 1,787 people with type 2 diabetes taking oral hypoglycemic medication. Diabetes ...
Tópico(s): Cardiac Health and Mental Health
2013 - Elsevier BV | Psychosomatics
Alana H.T. Nguyen, Mélanie Béland, Yaned Gaitan, Maxime Bouchard,
Current therapeutic strategies against Wilms' tumor (WT) reach 80% to 85% success rate. In spite of this, a remaining 15% to 20% of tumors relapse and are associated with increased metastasis and poor prognosis. To identify new regulators of WT progression, we screened for developmental target genes of Pax2, a key regulator of kidney development and a WT signature gene. We show that one of these target genes, calcineurin A-binding protein (CnABP), is coexpressed with Pax2 during kidney development ...
Tópico(s): Orthopaedic implants and arthroplasty
2009 - American Association for Cancer Research | Molecular Cancer Research
Abdallah Samad, Éric Villeneuve, François Morency, Mathieu Béland, Maxime Lapalme,
UAV rotors are at a high risk of ice accumulation during their operations in icing conditions. Thermal ice protection systems (IPSs) are being employed as a means of protecting rotor blades from ice, yet designing the appropriate IPS with the required heating density remains a challenge. In this work, a reduced-order modeling technique based on the Unsteady Vortex Lattice Method (UVLM) is proposed as a way to predicting rotor icing and to calculate the required anti-icing heat loads. The UVLM is gaining ...
Tópico(s): Cryospheric studies and observations
2024 - Multidisciplinary Digital Publishing Institute | Drones
Derek Harvey, Éric Villeneuve, Mathieu Béland, Maxime Lapalme,
The Bell Textron APT70 is a UAV concept developed for last mile delivery and other usual applications. It performs vertical takeoff and transition into aircraft mode for forward flight. It includes four rotor each with four rotating blades. A test campaign has been performed to study the effects of ice accretion on rotor performance through a parametric study of different parameters, namely MVD, LWC, rotor speed, and pitch angle. This paper presents the last experimentations of this campaign for ...
Tópico(s): Aerodynamics and Fluid Dynamics Research
2024 - Multidisciplinary Digital Publishing Institute | Drones
Derek Harvey, Éric Villeneuve, C. Volat, Mathieu Béland, Maxime Lapalme,
<div class="section abstract"><div class="htmlview paragraph">In this research, the performance of two commercially available icephobic coatings is evaluated on an 81% scaled-down version of the Bell Flight APT 70 drone propeller. Tests are performed in an icing wind tunnel (IWT) under selected severe icing conditions to test the ice protection capability of coatings against both glaze and rime ice. Two different coating formulations are used, one is a polydimethylsiloxane (PDMS) acetoxy ...
Tópico(s): Aerospace Engineering and Energy Systems
2023 - | SAE technical papers on CD-ROM/SAE technical paper series
Annie Beaudry, Simon Jacques-Ricard, Anaïs Darracq, Nicolas Sgarioto, Araceli Garcia, Teresita Rode García, William Lemieux, Kathie Béland, Élie Haddad, Paulo Cordeiro, Michel Duval, Serge McGraw, Chantal Richer, Maxime Caron, François Marois, Pascal St-Onge, Daniel Sinnett, Xavier Banquy, Noël J.‐M. Raynal,
Neuroblastoma, the most common type of pediatric extracranial solid tumor, causes 10% of childhood cancer deaths. Despite intensive multimodal treatment, the outcomes of high-risk neuroblastoma remain poor. We urgently need to develop new therapies with safe long-term toxicity profiles for rapid testing in clinical trials. Drug repurposing is a promising approach to meet these needs. Here, we investigated disulfiram, a safe and successful chronic alcoholism treatment with known anticancer and epigenetic ...
Tópico(s): Protein Degradation and Inhibitors
2023 - Nature Portfolio | Scientific Reports
Alana H.T. Nguyen, Mélanie Béland, Yaned Gaitan, Maxime Bouchard,
Abstract Wilms' tumor (WT) is a classical cancer type that arises from abnormal differentiation of kidney progenitor cells, and occurs at a frequency of 1 in 10,000 live births, accounting for approx. 90% of childhood kidney cancer. Abnormally high levels of Pax2 (paired-box protein 2), a key regulator of kidney development, have been observed in both WT and renal cell carcinoma, which correlate with proliferation and increased invasiveness. Therefore the misexpression of Pax2 and its target genes ...
Tópico(s): Renal and related cancers
2009 - American Association for Cancer Research | Cancer Research
Ning Qing Liu, Tommaso De Marchi, A. Mieke Timmermans, Robin Beekhof, Anita Trapman-Jansen, Renée Foekens, Maxime P. Look, Carolien H. M. van Deurzen, Paul N. Span, Fred C.G.J. Sweep, Julie Benedicte Brask, Vera Timmermans‐Wielenga, Reno Debets, John W.M. Martens, John A. Foekens, Arzu Umar,
... Kovalchuk O. Starlard-Davenport A. Chekhun V.F. Beland F. a Pogribny I.P. Role of ferritin ... Kovalchuk O. Starlard-Davenport A. Chekhun V.F. Beland F. a Pogribny I.P. Role of ferritin ...
Tópico(s): Epigenetics and DNA Methylation
2014 - Elsevier BV | Molecular & Cellular Proteomics
Danyel Lee, Jérémie Le Pen, Ahmad Yatim, Beihua Dong, Yann Aquino, Masato Ogishi, Rémi Pescarmona, Estelle Talouarn, Darawan Rinchai, Peng Zhang, Magali Perret, Zhiyong Liu, Iolanda Jordán, Şefika Elmas Bozdemir, Gülsüm İclal Bayhan, Camille Beaufils, Lucy Bizien, Aurélie Bisiaux, Wei‐Te Lei, Milena Hasan, Jie Chen, Christina Gaughan, Abhishek Asthana, Valentina Libri, Joseph M. Luna, Fabrice Jaffré, Hans-Heinrich Hoffmann, Eleftherios Michailidis, Marion Moreews, Yoann Seeleuthner, Kaya Bilgüvar, Shrikant Mane, Carlos Flores, Yu Zhang, Andrés A. Arias, Rasheed Bailey, Agatha Schlüter, Baptiste Milisavljevic, Benedetta Bigio, Tom Le Voyer, Marie Materna, Adrian Gervais, Marcela Moncada‐Vélez, Francesca Pala, Tomi Lazarov, Romain Lévy, Anna‐Lena Neehus, Jérémie Rosain, Jessica N. Peel, Yi‐Hao Chan, Marie‐Paule Morin, Rosa Pino, Serkan Belkaya, Lazaro Lorenzo, Jordi Antón, Selket Delafontaine, Julie Toubiana, Fanny Bajolle, Victòria Fumadó, Marta L. DeDiego, Nadhira Fidouh, Flore Rozenberg, Jordi Pèrez‐Tur, Shuibing Chen, Todd Evans, Frédéric Geissmann, Pierre Lebon, Susan R. Weiss, Damien Bonnet, Xavier Duval, Qiang Pan‐Hammarström, Anna M. Planas, Isabelle Meyts, Filomeen Haerynck, Aurora Pujol, Vanessa Sancho‐Shimizu, Clifford L. Dalgard, Jacinta Bustamante, Anne Puel, Stéphanie Boisson‐Dupuis, Bertrand Boisson, Tom Maniatis, Qian Zhang, Paul Bastard, Luigi D. Notarangelo, Vivien Béziat, Rebeca Pérez de Diego, Carlos Rodríguez‐Gallego, Helen C. Su, Richard P. Lifton, Emmanuelle Jouanguy, Aurélie Cobat, Laia Alsina, Sevgi Keleş, Élie Haddad, Laurent Abel, Alexandre Bélot, Lluís Quintana‐Murci, Charles M. Rice, Robert H. Silverman, Shen‐Ying Zhang, Jean‐Laurent Casanova, Loubna Alavoine, Sylvie Behillil, Charles Burdet, Charlotte Charpentier, Aline Dechanet, Diane Descamps, Xavier Duval, Jean-Luc Ecobichon, Vincent Enouf, Wahiba Frezouls, Nadhira Houhou, Ouifiya Kafif, Jonathan Lehacaut, Sophie Letrou, Bruno Lina, Jean‐Christophe Lucet, Pauline Manchon, Mariama Nouroudine, Valentine Piquard, Caroline Quintin, Michaël Thy, Sarah Tubiana, Sylvie van der Werf, Valérie Vignali, Benoît Visseaux, Yazdan Yazdanpanah, Abir Chahine, Nawal Waucquier, Maria-Claire Migaud, Dominique Deplanque, F. Djossou, Mayka Mergeay-Fabre, Aude Lucarelli, Magalie Demar, Léa Bruneau, Patrick Gérardin, Adrien Maillot, Christine Payet, Bruno Laviolle, Fabrice Laine, Christophe Paris, Mireille Desille‐Dugast, Julie Fouchard, Denis Malvy, Duc Hai Nguyen, Thierry Pistone, Pauline Perreau, Valérie Gissot, Carole L. E. Goas, Samatha Montagne, Lucie Richard, Catherine Chirouze, Kévin Bouiller, Maxime Desmarets, Alexandre Meunier, Benjamin Lefèvre, Hélène Jeulin, Karine Legrand, Sandra Lomazzi, Bernard Tardy, Amandine Gagneux-Brunon, Frédérique Bertholon, Élisabeth Botelho-Nevers, Kouakam Christelle, Leturque Nicolas, Layidé Roufai, Karine Amat, Sandrine Couffin-Cadièrgues, Hélène Esperou, Samia Hendou, Laurent Abel, Hassan Abolhassani, Sergio Aguilera, Alessandro Aiuti, Özge Metin Akcan, Nihal Akçay, Gülsüm Alkan, Suzan A. AlKhater, Luís M. Allende, Yosunkaya Alper, N. Amenzoui, Mark Anderson, Lisa M. Arkin, Mélodie Aubart, Iryna Avramenko, Şehnaz Aydemir, Zeynep Gökçe Gayretli Aydın, Caner Aytekin, Gökhan Aytekіn, Selma Erol Aytekin, Sílvia Yumi Bando, Kathie Béland, Serkan Belkaya, Catherine M. Biggs, Agurtzane Bilbao Aburto, Géraldine Blanchard-Rohner, Daniel Blázquez‐Gamero, Markéta Bloomfield, Dusan Bogunovic, Анастасія Бондаренко, A. Borghesi, Amed Aziz Bousfiha, Oksana Boyarchuk, Petter Brodin, Yenan T. Bryceson, Giorgia Bucciol, Valeria Calcaterra, Giorgio Casari, André Cavalcanti, Jale Bengi Çelik, George P. Chrousos, Roger Colobrán, Antônio Condino‐Neto, Francesca Conti, Megan A. Cooper, Taner Çoşkuner, Cyril Cyrus, Enza D’Auria, Selket Delafontaine, Beth A. Drolet, Burcu Bursal Duramaz, Loubna El Zein, Marwa H. Elnagdy, Melike Emiroğlu, Emine Hafize Erdeniz, Marianna Fabi, Hagit Baris Feldman, Jacques Fellay, Filip Fencl, Filippos Filippatos, Julie Freiss, Jiří Fremuth, Alenka Gagro, Blanca García‐Solis, Gianluca Vergine, Rafaela González‐Montelongo, Yahya Gül, Belgi̇n Gülhan, Sara Sebnem Kilic Gultekin, Marta Gut, Rabih Halwani, Lennart Hammarström, Nevin Hatipoğlu, James R. Heath, Sarah E. Henrickson, Elisa Hernández-Brito, Ilse Hoffman, Levi Hoste, Elena W.Y. Hsieh, Antonio Íñigo-Campos, Yuval Itan, Petr Jabandžiev, Bahar Kandemir, Saliha Kanık Yüksek, Hasan Kapaklı, Adem Karbuz, Özgür Kasapçopur, Robin Kechiche, Yasemin Kendir Demirkol, Ömer Kılıç, Stella Kim Hansen, Adam Klocperk, YL Lau, Jan Lebl, José M. Lorenzo-Salazar, C. Lucas, Majistor Maglorius, Laura Marque, Yeray Nóvoa Medina, Abián Montesdeoca Melián, Alexios‐Fotios A. Mentis, Michele T. Pato, Athanasios Michos, Joshua D. Milner, Trine H. Mogensen, Adrián Muñoz‐Barrera, Serdar Nepesov, João Farela Neves, Ashley Ng, Lisa F. P. Ng, Antonio Novelli, Giuseppe Novelli, Fatma Nur Öz, J. Gonzalo Ocejo‐Viñals, Satoshi Okada, Zerrin Orbak, Ahmet Osman Kılıç, Hind Ouair, Şadiye Kübra Tüter Öz, Tayfun Özçelık, Esra Akyüz Özkan, Aslınur Özkaya Parlakay, Carlos N. Pato, Estela Paz‐Artal,
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1 , OAS2 , or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)–sensing OAS1 and OAS2 generate 2′-5′-linked oligoadenylates (2-5A) that activate the single-stranded RNA–degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive ...
American Association for the Advancement of Science
... 435 134 Mitchum, R. K.; Freeman, J. P.; Beland, F. A.; Kadlubar, F. F. in “ Mass Spectrometry ... Anal. Chem. (1985), 57, 2287. 151 Puzo, G.; Maxime, B.; Prome, J.-C. Int. J. Mass Spectrom. ...
Tópico(s): Pesticide Residue Analysis and Safety
1989 - Wiley | Mass Spectrometry Reviews
Alex I. Wiesman, Victoria Madge, Edward A. Fon, Alain Dagher, D. Louis Collins, Sylvain Baillet, Sylvia Villeneuve, Judes Poirier, John C.S. Breitner, Mohamed Badawy, Sylvain Baillet, Andrée‐Ann Baril, Pierre Bellec, Véronique D. Bohbot, Danilo Bzdok, M. Mallar Chakravarty, D. Louis Collins, Mahsa Dadar, Simon Ducharme, Alan C. Evans, Claudine Gauthier, Maiya R. Geddes, Rick Hoge, Yasser Ituria-Medina, Maxime Montembeault, Gerhard Multhaup, Lisa Marie Munter, Natasha Rajah, Pedro Rosa‐Neto, Taylor W. Schmitz, Jean-Paul R. Soucy, R. Nathan Spreng, Christine L. Tardif, Étienne Vachon‐Presseau, Mohammadali Javanray, Meishan Ai, Philippe Amouyel, Jiarui Ao, Nicholas J. Ashton, Gabriel Aumont‐Rodrigue, Julie Bailly, Guilia Baracchini, Charles Beauchesne, Kaj Blennow, Christian Bocti, Lianne Boisvert, Ann Brinkmalm Westman, Nolan-Patrick Cunningham, Alain Dagher, Xing Dai, Thien Thanh Dang‐Vu, Samir Das, Marina Dauar-Tedeschi, Louis De Beaumont, Christine Déry, Maxime Descoteaux, Alfonso Fajardo Valdez, Vladimir Fonov, David Morgan, Jonathan Gallago, Aurelie Garrone, Louise Hudon, Adam Hull, Gabriel Jean, Anne Labonté, Robert Laforce, Marc Lalancette, Jean‐Charles Lambert, Jeannie‐Marie Leoutsakos, Laurence Maligne Bruneau, Julien Menes, Bratislav Misic, Béry Mohammediyan, Eugenia Nita Capota, Alix Noly‐Gandon, Adrian Eduardo Noriega de la Colina, Pierre Orban, Valentin Ourry, Cynthia Picard, Alexa Pichet Binette, Nathalie Prenevost, Ting Qiu, Marc James Quesnel, Charles Ramassamy, J.-P. Raoult, Jordana Remz, Erica Rothman, Isabel Sarty, Elisabeth Sylvain, Andràs Tikàsz, Stefanie A Tremblay, Jennifer Tremblay‐Mercier, Stéphanie Tullo, Jacob Turcotte, Irem Ulku, Paolo Vitali, Alfie Wearn, Kayla Williams, Yara Yakoub, Robert J. Zatorre, Henrik Zetterberg, Pierre Étienne, Serge Gauthier, Vasavan Nair, Jens C. Pruessner, Paul Aisen, Elena Anthal, Melissa Appleby, Nathalie Arbour, Daniel Auld, Gülebru Ayrancı, Alan Barkun, Thomas Beaudry, Christophe Bedetti, Marie‐Lise Béland, Fatiha Benbouhoud, Sophie Boutin, Jason Brandt, Leopoldina Carmo, Charles Edouard Carrier, Marianne Chapleau, Laksanun Cheewakriengkrai, Yalin Chen, Tima Chokr, Blandine Courcot, Doris Couture, Suzanne Craft, A. Claudio Cuello, Christian Dansereau, Leslie-Ann Daoust, Doris Dea, Clément Debacker, René Désautels, Sylvie Dubuc, Guerda Duclair, Marianne Dufour, Alana Dunlop, Mark J. Eisenberg, Rana El-Khoury, M Elie, Sarah Farzin, Anne-Marie Faubert, Fabiola Ferdinand, David Fontaine, Josée Frappier, Joanne Frenette, Guylaine Gagné, Valérie Gervais, Renuka Giles, Julie Gonneaud, Renee Gordon, Claudia Greco, Brittany Intzandt, Clifford R. Jack, Benoı̂t Jutras, Justin Kat, Christina Kazazian, Zaven S. Khachaturian, David S. Knopman, Theresa Köbe, Penelope Kostopoulos, Marie‐Élyse Lafaille‐Magnan, Felix Lapalme, Corina Lazarenco, Gloria Leblond-Baccichet, Tanya Lee, Marilou Lefebvre, David Lemay, Claude Lepage, Illana Leppert, Li Cai, Cécile Madjar, Laura Mahar, David Maillet, Jean-Robert Maltais, Axel Mathieu, Sulantha Mathotaarachchi, Ginette Mayrand, Melissa McSweeney, Pierre‐François Meyer, Diane Michaud, Justin Miron, Thomas J. Montine, John C. Morris, Jamie Near, Holly Newbold-Fox, Nathalie Nilsson, Hazal Ozlen, Véronique Pagé, Tharick A. Pascoal, Sandra Peillieux, Mirela Petkova, Morteza Pishnamazi, Galina Pogossova, Alexandre Poirier, Jean-Baptiste Poline, Sheida Rabipour, Marie-Josée Richer, Pierre Rioux, Mark A. Sager, Eunice Farah Saint-Fort, Alyssa Salaciak, Mélissa Savard, Matthew Settimi, Reisa A. Sperling, Frédéric St‐Onge, Cherie Strikwerda‐Brown, Sivaniya Subramaniapillai, Shirin Tabrizi, Angela Tam, Pierre N. Tariot, Eduard Teigner, Louise Théroux, Ronald G. Thomas, Paule‐Joanne Toussaint, Christina Tremblay, Miranda Tuwaig, Isabelle Vallée, Vinod Venugopalan, Sander C.J. Verfaillie, Jacob W. Vogel, Karen Wan, Seqian Wang, Elsa Yu, Isabelle Beaulieu‐Boire, Pierre Blanchet, Sarah Bogard, Manon Bouchard, Sylvain Chouinard, Francesca Cicchetti, Martin Cloutier, Alain Dagher, Samir Das, Clotilde Degroot, Alex Désautels, Marie Dion, Janelle Drouin‐Ouellet, Anne‐Marie Dufresne, Nicolas Dupré, Antoine Duquette, Thomas M. Durcan, Lesley K. Fellows, Edward A. Fon, Jean‐François Gagnon, Ziv Gan-Or, Angela Genge, Nicolas Jodoin, Jason Karamchandani, Anne‐Louise Lafontaine, Mélanie Langlois, Etienne Léveillé, Martin Lévesque, Calvin Melmed, Oury Monchi, Jacques Montplaisir, Michel Panisset, Martin Parent, Minh-Thy Pham-An, Jean-Baptiste Poline, Ronald B. Postuma, Emmanuelle Pourcher, Trisha Rao, J. Rivest, Guy A. Rouleau, Madeleine Sharp, Valérie Soland, Michael Sidel, Sonia Lai Wing Sun, Alexander Thiel, Paolo Vitali,
Abstract Parkinson’s disease (PD) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (SN) and the locus coeruleus (LC), respectively, resulting in motor and cognitive impairments. While SN dopamine dysfunction has clear neurophysiological effects, the association of reduced LC norepinephrine signaling with brain activity in PD remains to be established. We used neuromelanin-sensitive T1-weighted MRI (NPD = 58; NHC = 27) and task-free magnetoencephalography ( ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2024 - Oxford University Press | Brain