Jitka Stilund Hansen, Asger W. Nørgaard, Ismo K. Koponen, Jorid B. Sørli, Maya D. Paidi, Søren Hansen, Per Axel Clausen, Gunnar Damgård Nielsen, Peder Wolkoff, Søren Thor Larsen,
Inhalation of indoor air pollutants may cause airway irritation and inflammation and is suspected to worsen allergic reactions. Inflammation may be due to mucosal damage, upper (sensory) and lower (pulmonary) airway irritation due to activation of the trigeminal and vagal nerves, respectively, and to neurogenic inflammation. The terpene, d-limonene, is used as a fragrance in numerous consumer products. When limonene reacts with the pulmonary irritant ozone, a complex mixture of gas and particle phase ...
Tópico(s): Olfactory and Sensory Function Studies
2016 - Informa | Journal of Immunotoxicology
Produção Nacional
Revisado por pares
Reinert Korsnes, S. R. Souza, R. Donangelo, Alex Hansen, Maya Paczuski, Kim Sneppen,
Sea ice breaks up and regenerates rapidly during winter conditions in the Arctic. Analyzing satellite data from the Kara Sea, we find that the average ice floe size depends on weather conditions. Nevertheless, the frequency of floes of size A is a power law, N∼A−τ, where τ=1.6±0.2, for A less than approximately 100km2. This scale-invariant behavior suggests a competition between fracture due to strains in the ice field and refreezing of the fractures. A cellular model for this process gives results ...
Tópico(s): Cryospheric studies and observations
2003 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Poul Bjerregaard, Susanne Fjordside, Maria G. Hansen, Maya B. Petrova,
Adverse effects from organic mercury transported along aquatic food chains are health issues in humans and other top predators. Methyl mercury in organisms at the lower food chain levels is eliminated slowly, and laboratory studies have not clarified the role of selenium in the retention of methyl mercury in fish. Here, we investigated the effects of dietary selenium on the retention of organic and inorganic mercury in freshwater fish. Addition of selenite to the food augmented elimination of methyl ...
Tópico(s): Heavy Metal Exposure and Toxicity
2011 - American Chemical Society | Environmental Science & Technology
Maya Mokus, Ulrich Kragh‐Hansen, Pierre Letellier, Marc le Maire, Jesper V. Møller,
We describe the construction and use of a dodecyl sulfate-sensitive electrode cell to measure the activity of the detergent in biological samples. The electrode is based on the incorporation of a cetyltrimethylammonium/dodecyl sulfate complex in a siloxane polymer membrane. The cell records changes in the activity of SDS from 10−6to 10−5M SDS up to the critical micellar concentration. In aqueous solutions the cell follows Nernst' law with an electrometric response which is not affected by protein ...
Tópico(s): Analytical Chemistry and Sensors
1998 - Elsevier BV | Analytical Biochemistry
Raz Zarivach, Anat Bashan, Rita Berisio, Joerg Harms, Tamar Auerbach, Frank Schluenzen, Heike Bartels, David Baram, Erez Pyetan, Assa Sittner, Maya Amit, Harly A. S. Hansen, Maggie Kessler, Christa Liebe, Anja Wolff, Ilana Agmon, Ada Yonath,
Abstract High‐resolution structures of both ribosomal subunits revealed that most stages of protein biosynthesis, including decoding of genetic information, are navigated and controlled by the elaborate ribosomal architectural‐design. Remote interactions govern accurate substrate alignment within a flexible active‐site pocket [peptidyl transferase center (PTC)], and spatial considerations, due mainly to a universal mobile nucleotide, U2585, ensure proper chirality by interfering with D ‐amino‐acids ...
Tópico(s): Bacterial Genetics and Biotechnology
2004 - Wiley | Journal of Physical Organic Chemistry
Erland Björklund, Fernando Maya, Søren Alex Bak, Martin Hansen, José Manuel Estela, Vı́ctor Cerdà,
Tópico(s): Pesticide Residue Analysis and Safety
2011 - Elsevier BV | Microchemical Journal
Anne M. Hansen, Patricio Maya,
The adsorption-desorption behaviors of Cd and Pb in Lake Chapala sediments were studied through laboratory experiments and computer modelling. Experiments were designed to study the effects of water quality variations observed in the lake over two decades, on the sorption behaviors of these metals. Both Cd and Pb formed outer-sphere complexes with the functional groups on the sediment surface. Overall equilibrium adsorption constants obtained at low ionic strength of experimental background electrolytes ...
Tópico(s): Water Quality and Pollution Assessment
1997 - Elsevier BV | Environment International
C. Hansen, Maya Battikha, Masaru Teramoto,
The aims of this study were: (1) to characterize mild traumatic brain injury (mTBI), mTBI with skull fracture, and complicated mTBI in school-aged children seen at a Level I pediatric trauma center and (2) to examine the nature of imaging findings seen in children with mTBI with skull fracture and those with complicated mTBI.A total of 1777 pediatric patients (male: 1193 or 67.1%; age = 11.1 ± 3.5 years) sustaining mTBI who presented to the Emergency Department or directly to the trauma service in the years ...
Tópico(s): Spinal Fractures and Fixation Techniques
2018 - Elsevier BV | Pediatric Neurology
Aurélien Marabelle, Dung T. Le, Paolo A. Ascierto, Anna Maria Di Giacomo, Ana De Jesus‐Acosta, Jean-Pierre Delord, Ravit Geva, Maya Gottfried, Nicolas Penel, Aaron R. Hansen, Sarina A. Piha‐Paul, Toshihiko Doi, Bo Gao, Hyun Cheol Chung, José A. López-Martín, Yung-Jue Bang, Ronnie Shapira Frommer, Manisha H. Shah, Razi Ghori, Andrew K. Joe, Scott K. Pruitt, Luis A. Díaz,
Genomes of tumors that are deficient in DNA mismatch repair (dMMR) have high microsatellite instability (MSI-H) and harbor hundreds to thousands of somatic mutations that encode potential neoantigens. Such tumors are therefore likely to be immunogenic, triggering upregulation of immune checkpoint proteins. Pembrolizumab, an anti‒programmed death-1 monoclonal antibody, has antitumor activity against MSI-H/dMMR cancer. We report data from the phase II KEYNOTE-158 study of pembrolizumab in patients with ...
Tópico(s): Cancer Genomics and Diagnostics
2019 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Chenan Zhang, Libby M. Morimoto, Adam J. de Smith, Helen M. Hansen, Julio Gonzalez‐Maya, Alyson Endicott, Ivan Smirnov, Catherine Metayer, Qingyi Wei, William C. Eward, Joseph L. Wiemels, Kyle M. Walsh,
BACKGROUND Although increased height has been associated with osteosarcoma risk in previous epidemiologic studies, to the authors' knowledge the relative contribution of stature during different developmental timepoints remains unclear. Furthermore, the question of how genetic determinants of height impact osteosarcoma etiology remains unexplored. Genetic variants associated with stature in previous genome‐wide association studies may be biomarkers of osteosarcoma risk. METHODS The authors tested ...
Tópico(s): RNA Research and Splicing
2018 - Wiley | Cancer
Chenan Zhang, Quinn T. Ostrom, Helen M. Hansen, Julio Gonzalez‐Maya, Donglei Hu, Elad Ziv, Libby M. Morimoto, Adam J. de Smith, Ivo S. Muskens, Cassie Kline, Zalman Vaksman, Hákon Hákonarson, Sharon J. Diskin, Carol Kruchko, Jill S. Barnholtz‐Sloan, Vijay Ramaswamy, Francis Ali‐Osman, Melissa L. Bondy, Michael D. Taylor, Catherine Metayer, Joseph L. Wiemels, Kyle M. Walsh,
Abstract Background Ependymoma is a histologically defined central nervous system tumor most commonly occurring in childhood. Population-level incidence differences by race/ethnicity are observed, with individuals of European ancestry at highest risk. We aimed to determine whether extent of European genetic ancestry is associated with ependymoma risk in US populations. Methods In a multi-ethnic study of Californian children (327 cases, 1970 controls), we estimated the proportions of European, African, ...
Tópico(s): MicroRNA in disease regulation
2020 - Oxford University Press | Neuro-Oncology
Maya P Piddocke, Stefan Kreisz, Hans Peter Heldt-Hansen, Kristian Fog Nielsen, Lisbeth Olsson,
Tópico(s): Biofuel production and bioconversion
2009 - Springer Science+Business Media | Applied Microbiology and Biotechnology
Jessica Li, Sarah Whelan, Maya F. Kotturi, Déborah Meyran, Criselle D’Souza, Kyle Hansen, Spencer C. Liang, John Hunter, Joseph A. Trapani, Paul J. Neeson,
This study explored the novel immune checkpoint poliovirus receptor-related immunoglobulin domain-containing (PVRIG) in acute myeloid leukemia (AML). We showed that AML patient blasts consistently expressed the PVRIG ligand (poliovirus receptor-related 2, PVRL2). Furthermore, PVRIG blockade significantly enhanced NK cell killing of PVRL2+, poliovirus receptor (PVR)lo AML cell lines, and significantly increased NK cell activation and degranulation in the context of patient primary AML blasts. However, ...
Tópico(s): T-cell and B-cell Immunology
2020 - Ferrata Storti Foundation | Haematologica
Maya G. Jog, Maura E. Sackett, Stephen D. Kisty, John A. Hansen, Jessica F. Stephenson,
How infected hosts behave critically affects both their fitness and the transmission, and thus fitness, of their parasites. Understanding host–parasite coevolution therefore requires understanding the factors affecting infected host behaviour. This can usefully be decomposed into the current behavioural expression level and any infection-induced changes in that expression: each of these may have different implications for host and parasite fitness. For example, from the perspective of socially transmitted ...
Tópico(s): Amphibian and Reptile Biology
2022 - Elsevier BV | Animal Behaviour
Carlos Rodríguez‐Navas, Erland Björklund, Søren Alex Bak, Martin Hansen, Kristine A. Krogh, Fernando Maya, Rafael Forteza, Vı́ctor Cerdà,
Tópico(s): Water Treatment and Disinfection
2013 - Springer Science+Business Media | Archives of Environmental Contamination and Toxicology
Richard Hansen, Carlos Morales-Aguilar, Josephine Thompson, Ross Ensley, Enrique Hernández, Thomas Schreiner, Edgar Suyuc-Ley, Gustavo Martínez,
Abstract LiDAR coverage of a large contiguous area within the Mirador-Calakmul Karst Basin (MCKB) of northern Guatemala has identified a concentration of Preclassic Maya sites (ca. 1000 b.c.–a.d . 150) connected by causeways, forming a web of implied social, political, and economic interactions. This article is an introduction to one of the largest, contiguous, regional LiDAR studies published to date in the Maya Lowlands. More than 775 ancient Maya settlements are identified within the MCKB, and 189 ...
Tópico(s): Cultural Heritage Materials Analysis
2022 - Cambridge University Press | Ancient Mesoamerica
Richard Hansen, Ronald L. Bishop, Federico Fahsen,
Maya codex-style ceramics are among the most highly sought antiquities for collectors because of the fine art and extraordinary mythological scenes depicted on the pottery; yet the source of these ceramics has remained elusive. Recent archaeological explorations by the Regional Archaeological Investigation of the North Peten, Guatemala (RAINPEG) project at the site of Nakbe, Peten, have discovered codex-style ceramics in archaeological context. The hieroglyphs and painted scenes on the ceramics demonstrate ...
Tópico(s): Archaeological Research and Protection
1991 - Cambridge University Press | Ancient Mesoamerica
Richard Hansen, Steven R. Bozarth, John Jacob, David Wahl, Thomas Schreiner,
Archaeological and ecological investigations in the Mirador Basin of northern Guatemala have recovered archaeological, phytolith, palynological, and pedological data relevant to the early occupation and development of Maya civilization in a specific environmental matrix. Fluctuation in vegetation types as evident in cores and archaeological profiles suggest that the seasonally wet, forested bajo environment currently found in the northern Peten was anciently more of a perennially wet marsh system ...
Tópico(s): Pacific and Southeast Asian Studies
2002 - Cambridge University Press | Ancient Mesoamerica
Jeremy A. Sabloff, Gordon R. Willey,
... 814Kevin J. Johnston, Andrew J. Breckenridge, Barbara C. Hansen Paleoecological Evidence of an Early Postclassic Occupation in the Southwestern Maya Lowlands: Laguna Las Pozas, Guatemala, Latin American Antiquity ...
Tópico(s): Mexican Socioeconomic and Environmental Dynamics
1967 - University of New Mexico Press | Southwestern Journal of Anthropology
Maya P Piddocke, Alessandro Fazio, Wanwipa Vongsangnak, Man L Wong, Hans Peter Heldt-Hansen, Christopher T. Workman, Jens Nielsen, Lisbeth Olsson,
Addition of sugar syrups to the basic wort is a popular technique to achieve higher gravity in beer fermentations, but it results in dilution of the free amino nitrogen (FAN) content in the medium. The multicomponent protease enzyme Flavourzyme has beneficial effect on the brewer's yeast fermentation performance during high gravity fermentations as it increases the initial FAN value and results in higher FAN uptake, higher specific growth rate, higher ethanol yield and improved flavour profile.In ...
Tópico(s): Biofuel production and bioconversion
2011 - BioMed Central | Microbial Cell Factories
Chenan Zhang, Helen M. Hansen, Eleanor C. Semmes, Julio Gonzalez‐Maya, Libby M. Morimoto, Qingyi Wei, William C. Eward, Suzanne Bartholf DeWitt, Jillian H. Hurst, Catherine Metayer, Adam J. de Smith, Joseph L. Wiemels, Kyle M. Walsh,
Osteosarcoma, a malignant primary bone tumor most commonly diagnosed in children and adolescents, has a poorly understood genetic etiology. Genome-wide association studies (GWAS) and candidate-gene analyses have identified putative risk variants in subjects of European ancestry. However, despite higher incidence among African-American and Hispanic children, little is known regarding common heritable variation that contributes to osteosarcoma incidence and clinical presentation across racial/ethnic ...
Tópico(s): Sarcoma Diagnosis and Treatment
2019 - Elsevier BV | Bone
David Wahl, Roger Byrne, Thomas Schreiner, Richard Hansen,
Abstract An ∼8400 cal yr record of vegetation change from the northern Peten, Guatemala, provides new insights into the environmental history of the archaeological area known as the Mirador Basin. Pollen, loss on ignition, and magnetic susceptibility analyses indicate warm and humid conditions in the early to mid-Holocene. Evidence for a decrease in forest cover around 4600 cal yr B.P. coincides with the first appearance of Zea mays pollen, suggesting that human activity was responsible. The period ...
Tópico(s): Pleistocene-Era Hominins and Archaeology
2006 - Cambridge University Press | Quaternary Research
Tiffany Wu, Borislav Dejanovic, Vineela Gandham, Alvin Gogineni, Rose Edmonds, Stephen Schauer, Karpagam Srinivasan, Melanie A. Huntley, Yuanyuan Wang, Tzu-Ming Wang, Maj Hedehus, Kai Barck, Maya Stark, Hai Ngu, Oded Foreman, William J. Meilandt, Justin Elstrott, Michael Chang, David V. Hansen, Richard A.D. Carano, Morgan Sheng, Jesse E. Hanson,
Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focused on amyloidosis models. We find that glial cells show increased expression of classical complement components and the central component C3 in mouse models of amyloidosis (PS2APP) and more extensively tauopathy (TauP301S). Blocking complement function by deleting C3 ...
Tópico(s): Complement system in diseases
2019 - Cell Press | Cell Reports
Simone Kann, Joerg Blessmann, Yvonne Winkelmann, Jessica Hansen, Leonardo J. Maya Amaya, Gadith E. Rivera Salcedo, Hussein El Halas, Jonas Schmidt‐Chanasit, Latdamone Keoviengkhone, Vatsana Sopraseuth, Christina Deschermeier, Angela Mika,
Dengue virus (DENV) detection by polymerase chain reaction (PCR) facilitates diagnosis of dengue fever, which is the most frequent arboviral disease globally. Two studies were performed in countries with high dengue incidence, to assess the diagnostic performance of different PCR techniques.Two hundred and seventy-nine acute phase blood samples from febrile patients were analyzed for DENV by the RealStar Dengue RT-PCR kit (Altona Diagnostics) as gold standard in comparison with the Tropical Fever Core ...
Tópico(s): Malaria Research and Control
2021 - Wiley | Tropical Medicine & International Health
Maya Dewan, Jesse E. Hansen, D. James Cooper, Ken Tegtmeyer,
1Cincinnati Children's Hospital Medical Center, Cincinnati, OH 2Cincinnati, OH 3Cincinnati Children's Hospital, Cincinnati, OH
Tópico(s): Intensive Care Unit Cognitive Disorders
2019 - Lippincott Williams & Wilkins | Critical Care Medicine
David Wahl, Thomas Schreiner, Roger Byrne, Richard Hansen,
Aguada Zacatal is a reservoir located within a bajo 4 km west of Nakbe, Peten, Guatemala. It is 100 m in diameter and the surrounding berm is approximately 1 m tall. The small Classic period site of Zacatal is adjacent to the aguada. The reservoir's artificial lining prevents dry season desiccation and enhances microfossil preservation. In 1998 a 335 cm sediment core was taken from the center of the reservoir and analyzed for pollen, microscopic charcoal, and total organic matter. Core chronology, ...
Tópico(s): Pleistocene-Era Hominins and Archaeology
2007 - Cambridge University Press | Latin American Antiquity
Kevin J. Johnston, Andrew Breckenridge, Barbara C. S. Hansen,
Magnetic, palynological, and paleoecological data indicate that in the Río de la Pasión drainage, one of the most thoroughly investigated areas of the southern Maya lowlands, a refugee population remained in the Laguna Las Pozas basin long after the Classic Maya collapse and the Terminal Classic period, previously identified by archaeologists as eras of near-total regional abandonment. During the Early Postclassic period, ca. A. D. 900 to 1200, agriculturalists colonized and deforested the Laguna ...
Tópico(s): Pacific and Southeast Asian Studies
2001 - Cambridge University Press | Latin American Antiquity
Sarah Whelan, Eran Ophir, Maya F. Kotturi, Ofer Levy, Sudipto Ganguly, Ling Yan Leung, Ilan Vaknin, Sandeep Kumar, Liat Dassa, Kyle Hansen, David Bernados, Benjamin Murter, Abha Soni, Janis M. Taube, Amanda N. Fader, Tian‐Li Wang, Ie‐Ming Shih, Mark A. White, Drew M. Pardoll, Spencer C. Liang,
Although checkpoint inhibitors that block CTLA-4 and PD-1 have improved cancer immunotherapies, targeting additional checkpoint receptors may be required to broaden patient response to immunotherapy. PVRIG is a coinhibitory receptor of the DNAM/TIGIT/CD96 nectin family that binds to PVRL2. We report that antagonism of PVRIG and TIGIT, but not CD96, increased CD8+ T-cell cytokine production and cytotoxic activity. The inhibitory effect of PVRL2 was mediated by PVRIG and not TIGIT, demonstrating that ...
Tópico(s): Immunotherapy and Immune Responses
2019 - American Association for Cancer Research | Cancer Immunology Research
Eric Hansen, Carlos Rodríguez‐Navarro, Richard Hansen,
Tópico(s): Cultural Heritage Materials Analysis
1996 - Cambridge University Press | MRS Proceedings
Tópico(s): Archaeological and Geological Studies
2004 - EDITORIAL RAICES | Arqueología mexicana