Kate Buchacz, Miao-Jung Chen, Maree Kay Parisi, Maya Yoshida-Cervantes, Erin Antunez, Viva Delgado, Nicholas J. Moss, Susan Scheer,
Background Persons with unsuppressed HIV viral load (VL) who disengage from care may experience poor clinical outcomes and potentially transmit HIV. We assessed the feasibility and yield of using the San Francisco Department of Public Health (SFDPH) enhanced HIV surveillance system (eHARS) to identify and re-engage such persons in care. Methods Using SFDPH eHARS data as of 4/20/2012 (index date), we selected HIV-infected adults who were alive, had no reported VL or CD4 cell count results in the past ...
Tópico(s): Sex work and related issues
2015 - Public Library of Science | PLoS ONE
Yasushi Iwasaki, Maya Mimuro, Mari Yoshida, Gen Sobue, Yoshio Hashizume,
A clinical diagnosis of Creutzfeldt-Jakob disease (CJD) can be established readily in typical cases but not in atypical cases. To investigate the accuracy of clinical diagnosis of CJD, such diagnoses were evaluated retrospectively in autopsy cases. Sixty cases were clinically diagnosed as cases of CJD, of which seven were excluded on the basis of pathologic analysis. These seven misdiagnosed patients showed progressive dementia or disturbed consciousness. Myoclonus and periodic sharp-wave complexes ( ...
Tópico(s): Neurological diseases and metabolism
2008 - Elsevier BV | Journal of the Neurological Sciences
Ying Liu, Maya Mimuro, Mari Yoshida, Yoshio Hashizume, Hisayoshi Niwa, Shinichi Miyao, Nobuko Ujihira, Hiroyasu Akatsu,
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2008 - Springer Science+Business Media | Acta Neuropathologica
Yasushi Iwasaki, Maya Mimuro, Mari Yoshida, Tetsuyuki Kitamoto, Yoshio Hashizume,
Background: It is not known whether the clinical course of Japanese sporadic Creutzfeldt–Jakob disease (sCJD) cases differs from that of Caucasian sCJD cases. Patients and methods: To investigate the clinical course of Japanese sCJD, clinical findings from 29 patients with Japanese MM1-type sCJD were retrospectively evaluated and compared to Caucasian sCJD findings. Results: Survival of Japanese MM1-type sCJD up to the time of akinetic mutism state is similar to that of Caucasian subjects. However, ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2010 - Wiley | European Journal of Neurology
Yasushi Iwasaki, Maya Mimuro, Mari Yoshida, Yoshio Hashizume, Tetsuyuki Kitamoto, Gen Sobue,
We present five cases of dura mater-associated Creutzfeldt-Jakob disease (dura-CJD) that were analyzed clinicopathologically and review previous reports. The average age at dura mater transplantation was 54.4 +/- 7.3 years, and the average age at CJD onset was 66.0 +/- 8.2 years, with an average latency period of 11.6 +/- 1.1 years. The average age at death was 67.6 +/- 8.7 years, with an average CJD disease duration of 16.8 +/- 10.4 months. Symptoms of CJD onset in four patients who received dura mater transplantation ...
Tópico(s): Neurological diseases and metabolism
2007 - Wiley | Neuropathology
Yasushi Iwasaki, Keiko Mori, Masumi Ito, Shinsui Tatsumi, Maya Mimuro, Mari Yoshida,
A Japanese male patient presented with gait disturbance at the age of 69 years. His principal symptom was cerebellar ataxia for several years. He was initially diagnosed as having olivopontocerebellar atrophy because dysarthria and ataxia gradually developed, and head CT scan showed apparent atrophy of the cerebellum and brainstem and dilatation of the fourth ventricle. Later, he showed vertical gaze palsy, dysphagia, retrocollis, parkinsonism, axial dominant rigidity and grasp reflex, and therefore, ...
Tópico(s): Neurological and metabolic disorders
2013 - Wiley | Neuropathology
Maya Mimuro, Mari Yoshida, Shigeki Kuzuhara, Yasumasa Kokubo,
The high incidence of amyotrophic lateral sclerosis ( ALS ) and parkinsonism‐dementia complex ( PDC ) has been previously known in the K ii P eninsula of J apan and in G uam. Recently, the accumulation of various proteins, such as tau, trans‐activation response DNA binding protein 43 kDa (T DP ‐43), and alpha‐synuclein (α S yn), was reported in the brains of patients with ALS / PDC in G uam. To confirm whether similar findings are present in K ii ALS / PDC , we neuropathologically examined the brains and spinal ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2017 - Wiley | Neuropathology
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neurodegenerative disorders that show parkinsonism as their main symptom. Both PSP and CBD are sporadic tauopathies associated with hyperphosphorylated four‐repeat tau aggregation in neurons and glial cells. The characteristic pathologies of PSP are midbrain atrophy and the appearance of tufted astrocytes and globose‐type neurofibrillary tangles. PSP shows severe degeneration in the globus pallidus, substantia nigra, subthalamic ...
Tópico(s): Neurological disorders and treatments
2019 - Wiley | Neuropathology
Yasushi Iwasaki, Maya Mimuro, Mari Yoshida, Yoshio Hashizume, Masumi Ito, Tetsuyuki Kitamoto, Yoshihiro Wakayama, Gen Sobue,
Aquaporin-4 (AQP-4) is a water channel protein located on the plasma membrane of astrocytes and is regulated under various conditions. In the present study, a series of brains with sporadic Creutzfeldt-Jakob disease (sCJD) were investigated to determine the possible contribution of AQP-4 in the development of sCJD pathology. Six cases of subacute spongiform encephalopathy (SSE) and four cases of panencephalopathic (PE)-type sCJD were included. Increased AQP-4 immunoreactivity compared to that in controls ...
Tópico(s): Microbial metabolism and enzyme function
2007 - Wiley | Neuropathology
Misato Yasumura, Tomoyuki Yoshida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kouta Kanno, Takeshi Uemura, Keizo Takao, Kenji Sakimura, Takefumi Kikusui, Tsuyoshi Miyakawa, Masayoshi Mishina,
IL-1 receptor accessory protein-like 1 (IL1RAPL1) is responsible for nonsyndromic intellectual disability and is associated with autism. IL1RAPL1 mediates excitatory synapse formation through trans-synaptic interaction with PTPδ. Here, we showed that the spine density of cortical neurons was significantly reduced in IL1RAPL1 knockout mice. The spatial reference and working memories and remote fear memory were mildly impaired in IL1RAPL1 knockout mice. Furthermore, the behavioural flexibility was ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2014 - Nature Portfolio | Scientific Reports
Midori Nakajima, Elysa Widjaja, Shiro Baba, Yosuke Sato, R. Yoshida, Maya Tabei, Ayaka Okazaki, Satoru Sakuma, Stephanie Holowka, Ayako Ochi, O. Carter Snead, James T. Rutka, James M. Drake, Hideaki Shiraishi, Sam M. Doesburg, Hiroshi Otsubo,
Summary Objective To investigate whether the magnetoencephalography ( MEG ) single moving dipole ( SMD ) method could delineate the epileptic zone of focal cortical dysplasia ( FCD ) at the bottom of sulcus ( FCDB ). Methods We retrospectively analyzed 17 children (11 male; mean age 8.8 years, range 3–17 years) with FCD type II who underwent epilepsy surgery. We compared spatial congruence between the following: (1) MEG cluster and FCDB and (2) MEG cluster and FCD at the brain surface ( FCDS ). We measured the volume and ...
Tópico(s): Neonatal and fetal brain pathology
2016 - Wiley | Epilepsia
Yuichi Riku, Hirohisa Watanabe, Mari Yoshida, Maya Mimuro, Yasushi Iwasaki, Michihito Masuda, Shinsuke Ishigaki, Masahisa Katsuno, Gen Sobue,
Recent pathological studies indicate that neuronal loss and/or TAR DNA-binding protein-43 kDa (TDP-43) inclusions are frequent in the striatum of patients with TDP-43-related frontotemporal lobar degeneration (FTLD-TDP) and amyotrophic lateral sclerosis (ALS-TDP). However, no investigations have clarified the impact of such pathological changes on striatal neuronal outputs in these diseases. We analyzed pathological changes in the striatal efferent system of 59 consecutively autopsied patients with ...
Tópico(s): Neurological diseases and metabolism
2016 - Oxford University Press | Journal of Neuropathology & Experimental Neurology
Maya Putri Agustianingrum, S Yoshida, Nobuhiro Tsuji, Nokeun Park,
Solid solution strengthening effect was investigated in AlxCoCrNi medium-entropy alloy (MEA) with different Al content (x = 0–7 at.%). The result of X-ray diffraction indicates that the fully recrystallized phase was a single face-centered cubic (FCC) structure for all compositions. The average grain size regarding a twin boundary as a grain boundary was approximately 16 μm. Tensile testing shows that the yield strength increases with the addition of Al. Here, Labusch's approach to random solid solution ...
Tópico(s): Advanced materials and composites
2018 - Elsevier BV | Journal of Alloys and Compounds
Stacy L. Littlechild, Robert D. Young, Bruce Caterson, Hideyuki Yoshida, Maya Yamazaki, Kenji Sakimura, Andrew J. Quantock, Tomoya O. Akama,
Synthesis of keratan sulfate (KS) relies on coordinated action of multiple enzymes, including the N-acetylglucosamine-transferring enzyme, β-1,3-N-acetylglucosaminyltransferase-7 (β3GnT7). A mouse model deficient in β3GnT7 was developed to explore structural changes in KS and the extracellular matrix (ECM; i.e., the corneal stroma), elucidate the KS biosynthesis mechanism, and understand its role in corneal organization.A knockout vector for the β3GnT7-encoding gene, B3gnt7, was created to develop ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2018 - Cadmus Press | Investigative Ophthalmology & Visual Science
Mari Yoshida, Maya Hakozaki, Gohta Goshima,
Tópico(s): Photosynthetic Processes and Mechanisms
2023 - Nature Portfolio | Nature Plants
Hiroyasu Akatsu, Akira Hori, Takayuki Yamamoto, Mari Yoshida, Maya Mimuro, Yoshio Hashizume, Ikuo Tooyama, Eric M. Yezdimer,
Tópico(s): Alzheimer's disease research and treatments
2011 - Springer Science+Business Media | BioMetals
Zheng‐Tong Ding, Yin Wang, Yuping Jiang, Mari Yoshida, Maya Mimuro, Toshiaki Inagaki, Tamaki Iwase, Yoshio Hashizume,
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2006 - Springer Science+Business Media | Acta Neuropathologica
Zheng‐Tong Ding, Yin Wang, Yuping Jiang, Yoshio Hashizume, Mari Yoshida, Maya Mimuro, Toshiaki Inagaki, Tamaki Iwase,
Tópico(s): Ginkgo biloba and Cashew Applications
2006 - Springer Science+Business Media | Acta Neuropathologica
Yuki Kezuka, Maya Yoshida, Masahiko Tajika,
Formation of a calcite nanoring with a single cavity was confirmed during its crystal growth in an aqueous system.
Tópico(s): Bone Tissue Engineering Materials
2019 - Royal Society of Chemistry | CrystEngComm
Yuki Kezuka, Eita Tochigi, Hidenobu Murata, Maya Yoshida, Kenichiro Eguchi, Atsushi Nakahira, Yuichi Ikuhara, Masahiko Tajika,
Calcite nanoparticles are produced via CO2 gas bubbling in the Ca(OH)2 aqueous slurry and have been extensively used as filler materials for more than a century. However, the control of their morphology is not completely understood, even though it is technologically relevant in the industry, because detailed nanoscale investigations of their morphological changes during synthesis have only been recently conducted. In this study, c-axis-elongated calcite chainlike nanoparticles were synthesized via ...
Tópico(s): Magnesium Oxide Properties and Applications
2019 - American Chemical Society | Crystal Growth & Design
Yasushi Iwasaki, Keiko Mori, Masumi Ito, Yoshinari Kawai, Kenichiro Hoshino, Yuko Kawabata, Maya Mimuro, Mari Yoshida,
Patients with prion diseases can live for long periods of time in a state of akinetic mutism given appropriate management of their symptoms. To study symptom support in these cases, we performed gastrostomies on 3 patients with V180I genetic Creutzfeldt-Jakob disease (CJD) who had become akinetic and mute, and compared them to 14 other similar patients being fed by tube. In the 3 gastrostomy cases, there were no direct complications due to the gastrostomy or tube feeding, nor were there episodes ...
Tópico(s): Amyotrophic Lateral Sclerosis Research
2017 - Landes Bioscience | Prion
Yuichi Riku, Hirohisa Watanabe, Mari Yoshida, Maya Mimuro, Yasushi Iwasaki, Michihito Masuda, Shinsuke Ishigaki, Masahisa Katsuno, Gen Sobue,
In frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), recent studies have presumed relationships between cognitive declines and striatal dysfunctions. The striatum contributes to socio-cognitive functions by receiving glutamatergic inputs from the cerebral cortices. However, the vulnerability of these cortico-striatal inputs is unclear in these diseases. This study aimed to evaluate the glutamatergic inputs to the striatum from the cerebral cortices in patients with ...
Tópico(s): Alzheimer's disease research and treatments
2017 - Oxford University Press | Journal of Neuropathology & Experimental Neurology
Maya Mimuro, Mari Yoshida, Shinichi Miyao, Tomoko Harada, Koichi Ishiguro, Yoshio Hashizume,
Frontotemporal lobar degeneration-tau, Pick's disease subtype (PiD) is one of the major types of frontotemporal dementia, but its pathogenesis and disease mechanisms remain unclear. Here, we report a case of very early PiD. The patient was a 63-year-old healthy woman without dementia or any apparent psychosis. She was admitted to the hospital with multiple organ failure, and died three days later. The brain weighed 1050g and showed focal atrophy of the parahippocampal gyrus and right medial temporal ...
Tópico(s): Amyotrophic Lateral Sclerosis Research
2009 - Elsevier BV | Journal of the Neurological Sciences
Mariko Hashizume, Junko Takagi, Tomoki Kanehira, Kazuo Otake, Maya Mimuro, Mari Yoshida, Yoshio Hashizume,
We studied histologic findings of age-related change in the posterior pituitary gland focusing specifically on abnormal deposition of tau protein. Posterior pituitary glands from a total of 201 patients with mean age of 72, range 15 to 100 years, were dissected at autopsy, and semiquantitative analysis of tau protein deposition in the posterior pituitaries was performed. We confirmed that tau protein deposition in the posterior pituitary appears histologically as either a 'thread-like' or 'dot' form. ...
Tópico(s): Prion Diseases and Protein Misfolding
2010 - Wiley | Pathology International
Keiko Mori, Yasushi Iwasaki, Masumi Ito, Maya Mimuro, Mari Yoshida,
症例は死亡時86歳の男性である．進行性の歩行障害，筋強剛，認知症を呈した．静止時振戦，L-dopaの反応性，自律神経障害はなかったが，MIBG心筋シンチグラフィーの集積低下をみとめ，Lewy小体型認知症と臨床診断された．死亡後の病理診断は大脳皮質基底核変性症であった．全身病理では心臓交感神経終末が高度に脱落しており，MIBGの集積低下を反映していた．さらに中枢神経，消化管，副腎等にはみられなかったLewy小体が交感神経節に限局してみとめられた．MIBGの集積低下はLewy小体の存在を示唆するが，その広がりまでは予見できず，また偶発的にLewy小体が合併する事を臨床診断の際には考慮する必要がある．
Tópico(s): Neurological and metabolic disorders
2012 - | Rinsho Shinkeigaku
Ryosuke Tomio, Masahiro Toda, Toshiki Tomita, Masaki Yazawa, Maya Kono, Kaoru Ogawa, Kazunari Yoshida,
Tópico(s): Craniofacial Disorders and Treatments
2014 - Springer Science+Business Media | Acta Neurochirurgica
Shinsui Tatsumi, Toshiki Uchihara, Ikuko Aiba, Yasushi Iwasaki, Maya Mimuro, Ryōsuke Takahashi, Mari Yoshida,
Pretangles are defined under the light microscope as diffuse and granular tau immunoreactivity in neurons in tissue from patients with Alzheimer disease (AD) or corticobasal degeneration (CBD) and are considered to be a premature stage before neurofibrillary tangle formation. However, the ultrastructure of pretangles remains to be described. To clarify the similarities and differences between pretangles from patients with AD and CBD (AD-pretangles and CBD-pretangles, respectively), we examined cortical ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2014 - Springer Science+Business Media | Acta Neuropathologica Communications
Yasushi Iwasaki, Akio Akagi, Maya Mimuro, Tetsuyuki Kitamoto, Mari Yoshida,
Although Japanese cases of sporadic Creutzfeldt-Jakob disease (sCJD) generally involve longer survival periods compared to those from other countries, details regarding the factors influencing survival are unclear. To determine the influence of certain factors on survival, we retrospectively assessed 51 Japanese MM1-type sCJD patients with respect to background, clinical course, and disease management. No significant differences were found between men and women, tracheotomy and nontracheotomy patients, ...
Tópico(s): Prion Diseases and Protein Misfolding
2015 - Elsevier BV | Journal of the Neurological Sciences
Yasushi Iwasaki, Keiko Mori, Masumi Ito, Maya Mimuro, Tetsuyuki Kitamoto, Mari Yoshida,
A 78-year-old Japanese man presented with rapidly progressive dementia and gait disturbances. Eight months before the onset of clinical symptoms, diffusion-weighted magnetic resonance imaging (DWI) demonstrated hyperintensities in the right temporal, right parietal and left medial occipital cortices. Two weeks after symptom onset, DWI showed extensive hyperintensity in the bilateral cerebral cortex, with regions of higher brightness that existed prior to symptom onset still present. Four weeks after ...
Tópico(s): Neurological diseases and metabolism
2016 - Wiley | Neuropathology
Maya Kono, Wataru Kakegawa, Kazunari Yoshida, Michisuke Yuzaki,
Key points NMDA receptors (NMDARs) are required for long‐term depression (LTD) at parallel fibre–Purkinje cell synapses, but their cellular localization and physiological functions in vivo are unclear. NMDARs in molecular‐layer interneurons (MLIs), but not granule cells or Purkinje cells, are required for LTD, but not long‐term potentiation induced by low‐frequency stimulation of parallel fibres. Nitric oxide produced by NMDAR activation in MLIs probably mediates LTD induction. NMDARs in granule cells ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2018 - Wiley | The Journal of Physiology