Natalie Staplin, Richard Haynes, PK Judge, Christoph Wanner, Julie Green, Jonathan Emberson, David Preiss, KJ Mayne, SYA Ng, Emily Sammons, Dandan Zhu, Michael Hill, W. Grant Stevens, Karl Wallendszus, Susanne Brenner, AK Cheung, Zhihong Liu, J Li, LS Hooi, Wenjun Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Z.I. Cherney, Aldo P. Maggioni, Roberto Pontremoli, Rajat Deo, Shinichi Goto, Xavier Rosselló, Katherine R. Tuttle, Dominik Steubl, Michaela Petrini, Siegfried Seidi, Martin Landray, Colin Baigent, WG Herrington, Sharirose Abat, Riaz Rahman, Rizna Abdul Cader, MI Abdul Hafidz, MZ Abdul Wahab, NK Abdullah, Talal Abdulsamad, Masami Abe, Ned Abraham, Sarah Acheampong, P Achiri, JA Acosta, A A Adeleke, Vicki Adell, R Adewuyi-Dalton, Nihad Adnan, A Africano, Mohsen Agharazii, Frank G. Aguilar, A Aguilera, Ahmad Mukhtar, MK Ahmad, NA Ahmad, NH Ahmad, NI Ahmad, Norazinizah Ahmad Miswan, H Ahmad Rosdi, Iffat Ahmed, Sofia B. Ahmed, Sofia B. Ahmed, Joan Aiello, Alastair Aitken, R AitSadi, Sendogan Aker, S Akimoto, Akinwande A. Akinfolarin, S. Akram, Federico Alberici, Christian Albert, Luke Aldrich, M Alegata, Lacy M. Alexander, S Alfaress, Mohammad Alhadj Ali, Ahmed Ali, Ahmed Ali, Radica Z. Alicic, Arta Aliu, Ricardo López Almaraz, Rashid Almasarwah, Jussara Carnevale de Almeida, Alessia Aloisi, Laith Al‐Rabadi, Mark Dominik Alscher, Pedro Álvarez, Bader Al-Zeer, M. Ochoa de Olza Amat, Christopher S. Ambrose, Hany Ammar, Yu An, L Andriaccio, K Ansu, A Apostolidi, N. Arai, Hiroaki Araki, Shin‐ichi Araki, A Arbi, O Arechiga, Sarah Armstrong, Taylor J. Arnold, S Aronoff, W Arriaga, J Arroyo, Daniel Arteaga, Shingo Asahara, Akira Asai, N Asai, S Asano, M Asawa, M.F. Asmee, Filippo Aucella, Marc Augustin, Amanda Avery, Ahmed K. Awad, IY Awang, Motoharu Awazawa, A Axler, W Ayub, Zaid Azhari, Rocco Baccaro, C Badin, Benjamin M. Bagwell, Elisabeth Bahlmann-Kroll, AZ Bahtar, Colin Baigent, Diksha Bains, Harpreet S. Bajaj, Rebecca Baker, Enke Baldini, Bernhard Banas, Debasish Banerjee, Shogo Banno, Shweta Bansal, Simona Barberi, Stephen L. Barnes, Cecilia Barnini, C Barot, Kelly M. Schiabor Barrett, R Barrios, B Bartolomei Mecatti, I Barton, Janet Barton, W Basily, Sunita Bavanandan, Alex Baxter, Lewis C. Becker, Srinivasan Beddhu, Joachim Beige, S.A. Beigh, Samira Bell, Urs Benck, Amanda Beneat, Aisleen Bennett, David Bennett, Sarah Benyon, Jocelyn Berdeprado, Tobias Bergler, Albrecht Bergner, Marla J. Berry, Michele Bevilacqua, J Bhairoo, Sudhir Bhandari, Netra Prakash Bhandary, Ankeet S. Bhatt, Mukul Bhattarai, Mansi Bhavsar, Wei Bian, Francesca Bianchini, Simone Bianco, R. W. Bilous, Jennifer Bilton, Donatella Bilucaglia, C Bird, Divya Birudaraju, M Biscoveanu, Christine E. Blake, Nina Bleakley, K Bocchicchia, Sue C. Bodine, Richard Bodington, Simone Cosima Boedecker-Lips, Marie-Ève Bolduc, Shaun Bolton, Christopher Bond, Fadia El Boreky, Kenneth Boren, Ryotaro Bouchi, Laura Bough, Danijela Bovan, Chris Bowler, Louise Bowman, Navdeep Brar, C. Braun, A Breach, M. Breitenfeldt, Susanne Brenner, Brian Brettschneider, A Brewer, George J. Brewer, V Brindle, Elena Brioni, C. Titus Brown, Heather A. Brown, Louise Brown, R. H. Brown, Sarah Brown, Duncan L. Browne, K Bruce, Martina Brueckmann, Nigel J. Brunskill, Maria Bryant, Małgorzata M. Brzóska, Yang Bu, Cierra Buckman, Matthew J. Budoff, Michael Bullen, Andy Burke, Shane Burnette, Claire Burston, Martin Busch, John Bushnell, Susan Butler, Janine Büttner, Christopher D. Byrne, Antonio Gómez‐Caamaño, J Cadorna, Cesira Cafiero, Marianna P. Cagle, J. Cai, Kátia da Silva Calabrese, Carla L. Calvi, Brian Camilleri, S Camp, Danielle Campbell, Ryan Campbell, Haiyan Cao, Irene Capelli, M Caple, Ben Caplin, A Cardone, J Carle, V Carnall, Maurizio Caroppo, Sue Carr, Gianni Carraro, Michael W. Carson, P. Casares, Carmen E. Castillo, Claudia Castro, B Caudill, Vladimir Cejka, Martina Ceseri, Leslie Cham, Alanna M. Chamberlain, Jonathan Chambers, CBT Chan, J.C. Chan, YC Chan, Emily Chang, Emily Chang, Terri Chant, T Chavagnon, P Chellamuthu, Fei Chen, Jing Chen, Peng Chen, TM Chen, Y Chen, Y Chen, Ching‐Yu Cheng, Hong Cheng, MC Cheng, David Z.I. Cherney, AK Cheung, CH Ching, Nihil Chitalia, Rushab Choksi, Charles Nnanna Chukwu, Kevin K. Chung, Giuseppe Cianciolo, L Cipressa, Sarah L. Clark, Harry S. Clarke, Robert W. Clarke, Samantha Clarke, B. T. Cleveland, Edward Cole, H Coles, L Condurache, Andrew Connor,
Sodium-glucose co-transporter-2 (SGLT2) inhibitors reduce progression of chronic kidney disease and the risk of cardiovascular morbidity and mortality in a wide range of patients. However, their effects on kidney disease progression in some patients with chronic kidney disease are unclear because few clinical kidney outcomes occurred among such patients in the completed trials. In particular, some guidelines stratify their level of recommendation about who should be treated with SGLT2 inhibitors ...
Elsevier BV
Kimio Watanabe, Emiko Sato, Eikan Mishima, Mayu Watanabe, Takaaki Abe, Nobuyuki Takahashi, Masaaki Nakayama,
One third of the patients with chronic kidney disease (CKD) develop cognitive impairment, which is also an independent risk factor for mortality. However, the concise mechanism of cerebro-renal interaction has not been clarified. The present study examines the effects of uremic toxins on neuronal cells and analyzes the pathological condition of the brain using mouse hippocampal neuronal HT-22 cells and adenine-induced CKD model rats. Among the uremic toxins analyzed, indoxyl sulfate, indole, 3-indoleacetate, ...
Tópico(s): Epilepsy research and treatment
2021 - Elsevier BV | Heliyon
Nobuaki Hori, Masafumi Kadota, Mayu Watanabe, Yoshinori Ito, Norio Akaike, David O. Carpenter,
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2010 - Springer Science+Business Media | Cellular and Molecular Neurobiology
Sota Todoriki, Yui Hosoda, Tae Yamamoto, Mayu Watanabe, Akiyo Sekimoto, Hiroshi Satō, Takefumi Mori, Mariko Miyazaki, Nobuyuki Takahashi, Emiko Sato,
Uremic sarcopenia is a serious clinical problem associated with physical disability and increased morbidity and mortality. Methylglyoxal (MG) is a highly reactive, dicarbonyl uremic toxin that accumulates in the circulatory system in patients with chronic kidney disease (CKD) and is related to the pathology of uremic sarcopenia. The pathophysiology of uremic sarcopenia is multifactorial; however, the details remain unknown. We investigated the mechanisms of MG-induced muscle atrophy using mouse myoblast ...
Tópico(s): Dialysis and Renal Disease Management
2022 - Multidisciplinary Digital Publishing Institute | Toxins
David Nguyen, Padmaja Dhanasekaran, Margaret Nickel, Chiharu Mizuguchi, Mayu Watanabe, Hiroyuki Saito, Michael C. Phillips, Sissel Lund‐Katz,
The human apolipoprotein (apo) E4 isoform, which differs from wild-type apoE3 by the single amino acid substitution C112R, is associated with elevated risk of cardiovascular and Alzheimer's diseases, but the molecular basis for this variation between isoforms is not understood. Human apoE is a two-domain protein comprising an N-terminal helix bundle and a separately folded C-terminal region. Here, we examine the concept that the ability of the protein to bind to lipid surfaces is influenced by the ...
Tópico(s): Alzheimer's disease research and treatments
2014 - American Chemical Society | Biochemistry
Mayu Watanabe, Atsuko Nakatsuka, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Chigusa Higuchi, Akihiro Katayama, Sanae Teshigawara, Jun Eguchi, Daisuke Ogawa, Eijiro Watanabe, Jun Wada, Hirofumi Makino,
Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. Under an obese state, the upregulation of Pemt induces endoplasmic reticulum (ER) stress by increasing the PC/PE ratio in the liver. We targeted the Pemt gene in mice to explore the therapeutic impact of Pemt on the progression of diabetic nephropathy and diabetes, which was induced by the injection of streptozotocin (STZ). Although the blood ...
Tópico(s): Advanced Glycation End Products research
2014 - Public Library of Science | PLoS ONE
Yuko Kurose, Jun Wada, Motoko Kanzaki, Sanae Teshigawara, Atsuko Nakatsuka, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Akihiro Katayama, Mayu Watanabe, Chigusa Higuchi, Jun Eguchi, Nobuyuki Miyatake, Hirofumi Makino,
Abstract Background Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (T H 1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic nephropathy, by reversing the high glucose-induced up-regulation of cyclin dependent kinase inhibitors such as p27 Kip1 and p21 Cip1 . Methods We investigated the serum levels of Gal-9 in the patients with type 2 diabetes and various stages of ...
Tópico(s): Protein Tyrosine Phosphatases
2013 - BioMed Central | BMC Nephrology
Mayu Watanabe, Shinobu Takemura, Sayaka Kawakami, Emi Syouno, Hiromichi Kurosu, Masafumi Harada, Masayasu Iida,
Protonation sites of a chelating mono-protic ionic liquid (PIL) comprising N-hexylethylenediaminium (= HHexen+) depending on the counter anion were studied by 15N and 13C NMR spectroscopy and DFT calculation. In the case of the bis(trifluoromethanesulfonyl) amide (= TFSA−) PIL, the protonation occurred almost at the secondary amine, whereas the protonation occurred preferentially at the primary amine in the trifluoroacetate (= TFA−) PIL. The formation of a chelating copper(II) complex with the cationic unit ...
Tópico(s): Analytical Chemistry and Chromatography
2013 - Elsevier BV | Journal of Molecular Liquids
Ayaka Tsuboi, Mayu Watanabe, Tsutomu Kazumi, Keisuke Fukuo,
Aim: Although higher adiponectin levels predict a low risk of type 2 diabetes, elevated adiponectin levels predict higher mortality in older persons.Methods: We examined the associations of adiponectin with anthropometric, metabolic and hematological variables and renal function in 361 community-dwelling elderly women aged 76±8. Renal function was assessed using the estimated glomerular filtration rate (eGFR).Results: By univariate analysis, hemoglobin (r=−0.307, p<0.001) and creatinine-based eGFR ( ...
Tópico(s): Biomarkers in Disease Mechanisms
2013 - Japan Atherosclerosis Society | Journal of Atherosclerosis and Thrombosis
Mayu Watanabe, Akihiro Katayama, Hidetoshi Kagawa, Daisuke Ogawa, Jun Wada,
Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in the pregnant women with GDM. We enrolled 37 pregnant women with GDM and investigated the risk for AIT by comparing the patients with AIT (AIT group; n = 10) and without insulin therapy (Diet ...
Tópico(s): Prenatal Substance Exposure Effects
2016 - Hindawi Publishing Corporation | Journal of Diabetes Research
Ayaka Tsuboi, Mayu Watanabe, Tsutomu Kazumi, Keisuke Fukuo,
There have been inconsistent reports regarding the relationship between the iron status and coronary vascular diseases (CVD). Recently, low serum iron levels have been shown to be associated with mortality from CVD in women.The relationships between the serum iron levels and traditional and nontraditional risk factors for CVD were examined in 202 community-living elderly Japanese women.The women in the lowest iron tertile had higher high-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor- ...
Tópico(s): Biomarkers in Disease Mechanisms
2013 - Japan Atherosclerosis Society | Journal of Atherosclerosis and Thrombosis
Akiko Takenouchi, Ayaka Tsuboi, Mayu Terazawa-Watanabe, Miki Kurata, Keisuke Fukuo, Tsutomu Kazumi,
Abstract Background/Aims This study examined associations of visit-to-visit variability of glycemic control with annual decline in estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes attending an outpatient clinic. Methods Intrapersonal mean and coefficient of variation (CV) of 8-12 measurements of HbA1c and those of 4-6 measurements of fasting and post-breakfast plasma glucose (FPG and PPG, respectively) during the first 12 months after enrollment were calculated in a cohort ...
Tópico(s): Chronic Kidney Disease and Diabetes
2015 - Springer Nature | Journal of Diabetes & Metabolic Disorders
Yusuke Fukuyasu, Hitomi Kataoka, Miwako Honda, Toshihide Iwase, Hiroko Ogawa, Masaru Sato, Mayu Watanabe, Chikako Fujii, Jun Wada, Jennifer DeSantis, Mohammadreza Hojat, Joseph S. Gonnella,
Abstract Background Empathy, which involves understanding another person’s experiences and concerns, is an important component for developing physicians’ overall competence. This longitudinal study was designed to test the hypothesis that medical students’ empathy can be enhanced and sustained by Humanitude Care Methodology, which focuses on perception, emotion and speech. Methods This six-year longitudinal observational study examined 115 students who entered Okayama University Medical School in ...
Tópico(s): Film in Education and Therapy
2021 - BioMed Central | BMC Medical Education
Mayu Terazawa-Watanabe, Ayaka Tsuboi, Keisuke Fukuo, Tsutomu Kazumi,
Abstract Background: Substantially increased lipoprotein lipase (LPL) activity was reported in mice overexpressing adiponectin.Associations of serum adiponectin with serum preheparin LPL mass (serum LPL), fat mass, and fat distribution and markers of insulin resistance and inflammation were examined in 311 young and 148 middle-aged women.In young women, serum adiponectin was positively associated with high-density lipoprotein cholesterol (HDL-C) and serum LPL and inversely with body mass index (BMI), ...
Tópico(s): Cardiovascular Disease and Adiposity
2014 - Mary Ann Liebert, Inc. | Metabolic Syndrome and Related Disorders
Mayu Watanabe, Chisayo Nakayama, Haruka Yasuda, Masafumi Harada, Masayasu Iida,
The interactions of nickel(II) ions in a protic ionic liquid (PIL) comprising monoprotic N-alkyl (alkyl = hexyl or 2-ethylhexyl)–ethylenediaminium ions (HHexen+ or HEthexen+, respectively) combined with bis(trifluoromethanesulfonyl)amide (Tf2N−) or trifluoroacetate (TFA−) ions were investigated using visible (VIS) electronic and extended X-ray absorption fine structure (EXAFS) spectroscopy. These were compared to the analogous nickel(II) complexes in molecular solvents, and copper(II) ion in the same PIL ...
Tópico(s): Chemical and Physical Properties in Aqueous Solutions
2015 - Elsevier BV | Journal of Molecular Liquids
Akihiro Katayama, Atsuhito Tone, Mayu Watanabe, Sanae Teshigawara, Satoshi Miyamoto, Jun Eguchi, Atsuko Nakatsuka, Kenichi Shikata, Jun Wada,
The predictive low glucose management (PLGM) system was introduced in March 2018 in Japan. Although there are some reports demonstrating the benefit of PLGM in preventing hypoglycemia, no data are currently available in Japanese patients with type 1 diabetes mellitus (T1DM). The aim of the present study is to evaluate the effect of PLGM with sensor-augmented pump therapy in the prevention of hypoglycemia in Japanese patients.We included 16 patients with T1DM who used the MiniMed®640G system after ...
Tópico(s): Diabetes and associated disorders
2019 - Springer Science+Business Media | Diabetology International
Hitomi Kataoka, Akiko Tokinobu, Chikako Fujii, Mayu Watanabe, Mikako Obika,
More and more studies investigate medical students' empathy using the Jefferson Scale of Empathy (JSE). However, no norm data or cutoff scores of the JSE for Japanese medical students are available. This study therefore explored Japanese norm data and tentative cutoff scores for the Japanese translation of the JSE-medical student version (JSE-S) using 11 years of data obtained from matriculants from a medical school in Japan.Participants were 1,216 students (836 men and 380 women) who matriculated ...
Tópico(s): Clinical Reasoning and Diagnostic Skills
2023 - BioMed Central | BMC Medical Education
Koki Mise, Mariko Imamura, Satoshi Yamaguchi, Mayu Watanabe, Chigusa Higuchi, Akihiro Katayama, Satoshi Miyamoto, Haruhito A. Uchida, Atsuko Nakatsuka, Jun Eguchi, Kazuyuki Hida, Tatsuaki Nakato, Atsuhito Tone, Sanae Teshigawara, Takashi Matsuoka, Shinji Kamei, Kazutoshi Murakami, Ikki Shimizu, Katsuhiro Miyashita, Shinichiro Ando, Tomokazu Nunoue, Michihiro Yoshida, Masao Yamada, Kenichi Shikata, Jun Wada,
Background: Although various biomarkers predict cardiovascular event (CVE) in patients with diabetes, the relationship of urinary glycan profile with CVE in patients with diabetes remains unclear. Methods: Among 680 patients with type 2 diabetes, we examined the baseline urinary glycan signals binding to 45 lectins with different specificities. Primary outcome was defined as CVE including cardiovascular disease, stroke, and peripheral arterial disease. Results: During approximately a 5-year follow- ...
Tópico(s): Diet, Metabolism, and Disease
2021 - Frontiers Media | Frontiers in Cardiovascular Medicine
Sumio Ohtsuki, Mayu Kamoi, Yuki Watanabe, Hiroya Suzuki, Satoko Hori, Tetsuya Terasaki,
The ATP binding cassette transporter subtype A5 (ABCA5)-like transporters ABCA5, ABCA6, ABCA8, ABCA9 and ABCA10 form a unique gene cluster within the ABC transporter superfamily, though their function is still poorly understood. The purpose of this study is to examine whether ABCA5-like transporters may play a role in tumor development by measuring their mRNA levels in human tissues and tumors. Intense mRNA expression of human ABCA5-like transporters was detected in the brain. ABCA5 and ABCA8 mRNAs ...
Tópico(s): Trace Elements in Health
2007 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Shugo Nitta, Akitsugu Hatano, Mayu Yamada, M. Watanabe, Masato Kawai,
Tópico(s): Diamond and Carbon-based Materials Research
1983 - Elsevier BV | Journal of Non-Crystalline Solids
Tomoaki Yoshimura, Hideo Kuribara, Takeshi Matsuoka, Takashi Kodama, Mayu Iida, Takahiro Watanabe, Hiroshi Akiyama, Tamio Maitani, Satoshi Furui, Akihiro Hino,
The applicability of quantifying genetically modified (GM) maize and soy to processed foods was investigated using heat treatment processing models. The detection methods were based on real-time quantitative polymerase chain reaction (PCR) analysis. Ground seeds of insect resistant GM maize (MON810) and glyphosate tolerant Roundup Ready (RR) soy were dissolved in water and were heat treated by autoclaving for various time intervals. The calculated copy numbers of the recombinant and taxon specific deoxyribonucleic ...
Tópico(s): Insect Resistance and Genetics
2005 - American Chemical Society | Journal of Agricultural and Food Chemistry
Shuichiro Fujinaga, Akira Ito, Mayu Nakagawa, Tsuneki Watanabe, Yoshiyuki Ohtomo, Toshiaki Shimizu,
Tópico(s): Neurological and metabolic disorders
2013 - Springer Science+Business Media | European Journal of Pediatrics
Yoshihisa Urita, Mayu Goto, Toshiyasu Watanabe, Makoto Matsuzaki, A. Gomi, Mitsuyoshi KANO, Kouji Miyazaki, Hironori Kaneko,
The aim of this study was to investigate whether consumption of probiotic fermented milk containing Bifidobacterium bifidum YIT 10347 improves symptoms in patients with functional gastrointestinal disorders (FGID). Thirty-seven FGID patients (18 male, 19 female) aged 12–80 years (mean ± SD, 52.6 ± 17.5 years) whose condition had not improved despite being seen at several medical institutions consumed 100 mL/day of B. bifidum YIT 10347 fermented milk for 4 weeks. Symptoms were evaluated after the enrollment ...
Tópico(s): Gastroesophageal reflux and treatments
2015 - | Bioscience of Microbiota Food and Health
Takeshi Miyamoto, Akiyoshi Hirayama, Yuiko Sato, Tami Koboyashi, Eri Katsuyama, Hiroya Kanagawa, Hiroya Miyamoto, Tomoaki Mori, Shigeyuki Yoshida, Atsuhiro Fujie, Mayu Morita, Ryuichi Watanabe, Toshimi Tando, Kana Miyamoto, Takashi Tsuji, Atsushi Funayama, Masaya Nakamura, Morio Matsumoto, Tomoyoshi Soga, Masaru Tomita, Yoshiaki Toyama,
Osteoporosis is characterized as a metabolic disorder of bone tissue, and various metabolic markers are now available to support its diagnosis and evaluate treatment effects. Substances produced as end products of metabolomic activities are the correlated factors to the biological or metabolic status, and thus, metabolites are considered highly sensitive markers of particular pathological states, including osteoporosis. Here we undertook comprehensive serum metabolomics analysis in postmenopausal ...
Tópico(s): Bone Metabolism and Diseases
2016 - Elsevier BV | Bone
Mayu Kasubuchi, Keita Watanabe, Kanako Hirano, Daisuke Inoue, Xuan Li, Kazuya Terasawa, Morichika Konishi, Nobuyuki Itoh, Ikuo Kimura,
Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors. Progesterone affects cell proliferation and survival via non-genomic effects. In this process, membrane progesterone receptors (mPRα, mPRβ, mPRγ, mPRδ, and mPRε) were identified as putative G protein-coupled receptors (GPCRs) for progesterone. However, the structure, ...
Tópico(s): Receptor Mechanisms and Signaling
2017 - Nature Portfolio | Scientific Reports
Mayu Nishimura, Tadashi Watanabe, Syota Yagi, Takahiro Yamanaka, Masahiro Fujimuro,
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. KSHV establishes a life-long infection in its host and alternates between a latent and lytic infection state. During lytic infection, lytic-related genes are expressed in a temporal manner and categorized as immediate early, early, and late gene transcripts. ORF34 is an early-late gene that interacts with several viral transcription-associated ...
Tópico(s): Herpesvirus Infections and Treatments
2017 - Nature Portfolio | Scientific Reports
Takeshi Miyamoto, Akiyoshi Hirayama, Yuiko Sato, Tami Koboyashi, Eri Katsuyama, Hiroya Kanagawa, Atsuhiro Fujie, Mayu Morita, Ryuichi Watanabe, Toshimi Tando, Kana Miyamoto, Takashi Tsuji, Atsushi Funayama, Tomoyoshi Soga, Masaru Tomita, Masaya Nakamura, Morio Matsumoto,
Osteoporosis is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. Low bone mass and/or pre-existing bone fragility fractures serve as diagnostic criteria in deciding when to start medication for osteoporosis. Although osteoporosis is a metabolic disorder, metabolic markers to predict reduced bone mass are unknown. Here, we show serum metabolomics profiles of women grouped as pre-menopausal with normal bone mineral density (BMD) (normal estrogen and normal ...
Tópico(s): Bone Metabolism and Diseases
2018 - Elsevier BV | Bone Reports
Junshi Yazaki, Yusuke Kawashima, Taisaku Ogawa, Atsuo Kobayashi, Mayu Okoshi, Takashi Watanabe, Suguru Yoshida, Isao Kii, Shohei Egami, Masayuki Amagai, Takamitsu Hosoya, Katsuyuki Shiroguchi, Osamu Ohara,
Highly sensitive protein quantification enables the detection of a small number of protein molecules that serve as markers/triggers for various biological phenomena, such as cancer. Here, we describe the development of a highly sensitive protein quantification system called HaloTag protein barcoding. The method involves covalent linking of a target protein to a unique molecule counting oligonucleotide at a 1:1 conjugation ratio based on an azido-cycloalkyne click reaction. The sensitivity of the ...
Tópico(s): Mast cells and histamine
2019 - Oxford University Press | Nucleic Acids Research
Mayu Oomuro, Daisuke Watanabe, Yukiko Sugimoto, Taku Kato, Yasuo Motoyama, Tetsuya Watanabe, Hiroshi Takagi,
High-gravity brewing has been used to reduce costs and energy, as well as to produce new types of beer with high alcohol content. To identify the key metabolic pathways underlying efficient high-gravity brewing, we explored metabolites that were highly accumulated during alcoholic fermentation under high-maltose conditions using bottom-fermenting brewer's yeast, Saccharomyces pastorianus. Based on metabolomic data, we focused on S-adenosylmethionine (SAM), which may be involved in glycolysis and ...
Tópico(s): Fungal and yeast genetics research
2018 - Elsevier BV | Journal of Bioscience and Bioengineering
... s diseaseYasuhiro Tanaka, Takashi Tsuboi, June S. Levitt, Mayu Tanaka, Noriyoshi Tanaka, Hirohisa Watanabe and Masahisa Katsuno IEEE Access5 (22199-22208)Assessment ...
Tópico(s): Hearing Loss and Rehabilitation
1963 - American Speech–Language–Hearing Association | Journal of Speech and Hearing Disorders