Fatma Al-Husseiny, Mohamed Ahmed Sobh, Rehab H. Ashour, Samah Foud, Tarek Medhat, Abdel‐Hady El‐Gilany, Doaa M. Elghannam, Hassan Abdel-Ghaffar, Mohamed Saad, Mohamed Sobh,
Cisplatin is a nephrotoxic chemotherapeutic agent. So, preventive measures worth to be evaluated. Human amniotic fluid stem cells (hAFSCs) in prevention or amelioration of cisplatin-induced acute kidney injury (AKI) in Sprague-Dawley rates have been tested.80 Sprague-Dawley rats (250~300 g) were used and divided into 4 major groups, 20 rats each. Group I: Saline-injected group. Group II: Cisplatin-injected group (5 mg/kg I.P). Group III: Cisplatin-injected and hAFSCs-treated group (5×10⁶ hAFSCs I.V. ...
Tópico(s): Sesame and Sesamin Research
2016 - | International Journal of Stem Cells
Nesrine S. El-Mezayen, Mennat‐Allah Magdy Attia, Mohanad Yehia Shafik, Hadeer Galal Gowied, Hadeer Ahmed Abdel‐Aal, Sara Medhat Abdel‐Hady, Mostafa Said Ghazy,
A recent approach to cure neurodegenerative diseases is to reprogram fibroblasts into functioning neurons using multiple exogenous transcription factors (TFs) and micro-RNAs. Administering agents that can endogenously induce these TFs may bypass the limitations of this approach. Astrocytes may represent a part of the extrahepatic-stellate system involved in vitamin-A (VA ) homeostasis. Activated-stellate cells lose their VA -storage capacity, and this was previously applied for hepatic-stellate cells ( ...
Tópico(s): Nerve injury and regeneration
2023 - Wiley | CNS Neuroscience & Therapeutics
Mohamed Hessein, Saad M. El‐Gendy, Attallah A Mohamed, El Awaday M Kamel, AM Abdel Hady, Medhat Amina, Charles E. Rogler,
Hepatitis B virus is implicated in the development of hepatocellular caracinoma. No oncogenes have been identified within the viral genome. Furthermore, it frequently fragments after integration into the hepatocyte genome. Simultaneous investigations of hepatitis B virus integration patterns and genetic changes in precancerous tissues are important to understand the role played by hepatitis B virus integration in hepatocellular caracinoma.We used a combination approach of dual characterization of ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2005 - SAGE Publishing | Tumori Journal
Mohamed Mohamed El-Naggar, Ghada El-Nady, Rawia I. Badr, Medhat A. El-Daker, Hesham Abdel‐Hady,
Genetically determined variation in the magnitude of inflammatory response may play a role in determining the risk of developing neonatal sepsis, as well as its outcome. To test the hypothesis that interleukin-6 (IL)-6 -174, IL-10 -1082 genetic polym
Tópico(s): Immune Response and Inflammation
2015 - Thieme Medical Publishers (Germany) | Journal of Pediatric Infectious Diseases
Hesham Abdel‐Hady, Samia Hawas, Medhat A. El-Daker, Rania Abd El-Hamid El-Kady,
Extended-spectrum beta-lactamase producing (ESBL) Klebsiella pneumoniae is an important cause of nosocomial infections in neonatal intensive care units (NICUs). Our objectives were to determine (1) the incidence of ESBL K. pneumoniae in our NICU, (2) the frequency of SHV-1 and SHV-2 gene acquisition among ESBL K. pneumoniae isolates, (3) the risk factors associated with ESBL K. pneumoniae infection and (4) the clinical outcomes of infected infants. We conducted a prospective surveillance study in our ...
Tópico(s): Urinary Tract Infections Management
2008 - Springer Nature | Journal of Perinatology
Abdel Hady A. Abdel Wahab, Medhat S. El-Halawany, Ahmed Emam, Ammar Elfiky, Zakaria Y. Abd Elmageed,
Context: The incidence rate of hepatocellular carcinoma (HCC) is higher in developing countries, and most cases are associated with chronic hepatitis C virus (HCV) infection.Objective: To evaluate the circulating proteins as liver biomarkers for the identification of HCC associated with HCV infection in Egyptian patients using LC-MS/MS analysis.Methods: Blood sera were collected from 31 HCC patients and the fractionated proteins were subjected to LC-MS/MS analysis. Protein candidates were validated ...
Tópico(s): Lipid metabolism and disorders
2016 - Taylor & Francis | Biomarkers
Eman Z. Kandeel, Lobna Refaat, Raafat Abdelfatah, Mohamed Samra, Ahmed Bayoumi, Mona S. Abdellateif, Hend Abdel-Hady, Mohamed Ali, Medhat Khafagy,
Background COVID-19 viral pandemic caused many mortalities in cancer patients especially those with hematological malignancies. The immunological response to COVID-19 infection is responsible for the outcome of cases whether mild, severe or critical.Case presentation Two cases presented with moderate COVID-19 viral infection, concomitant with acute myeloid leukemia and T acute lymphoblastic leukemia, respectively. Surprisingly, after the administration of COVID-19 supportive therapy, the cases showed ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Maney Publishing | Hematology
Nadia El-Guendy, Reham Helwa, Medhat S. El-Halawany, Shimaa Abdel Rahman Ali, Marwa Tantawy, Nelly Alieldin, Shawky Abdel Hamid Fouad, Hany Saeid, Abdel-Hady Ali Abdel-Wahab,
MicroRNAs (miRNAs) have been repeatedly shown to play important roles in liver pathologies, including hepatitis, liver cirrhosis, and liver cancer. Egypt has the highest hepatitis C virus (HCV) infection rate worldwide, predominantly involving genotype-4.In this study, we attempted to characterize the miRNA profile of the poorly studied genotype 4 of HCV in chronically infected Egyptian patients to obtain a better understanding of the disease and its complications and help in the design of better ...
Tópico(s): Circular RNAs in diseases
2016 - Kowsar Publishing | Hepatitis Monthly
Medhat S. El-Halawany, Heba Ismail, Ahmed A. Zeeneldin, Ammar Elfiky, Marwa Tantawy, Mohamed H. Kobaisi, Ikram Hamed, Abdel Hady A. Abdel Wahab,
Hepatocellular carcinoma (HCC) is a lethal malignancy with poor prognosis and limited treatment options. Transarterial chemoembolization (TACE) using chemotherapy agents—doxorubicin and cisplatin—is an accepted treatment option for locally advanced hepatocellular carcinoma. In the current study, we analyzed the expression pattern of a selected panel of 94 miRNAs in archival samples that were collected prior to treatment from 15 Egyptian patients diagnosed with advanced hepatocelleular carcinoma. We ...
Tópico(s): Cancer-related molecular mechanisms research
2015 - Hindawi Publishing Corporation | BioMed Research International
Mohamed-Ahdy AA Saad, Mohamed Sobh, Fatma Al-Husseiny, Mohamed-Ahmed Sobh, Rehab H. Ashour, Samah Foud, Tarek Medhat, Abdel-Hady Algilany,
Tópico(s): Biomedical Research and Pathophysiology
2015 - Oxford University Press | Nephrology Dialysis Transplantation
Marwa Y. Abdel Tawwab, Bothaina M. Abdel-Hady, Rizk Abd El-Moneim Rizk, Medhat W. Shafaa,
Nanofibrous mats were fabricated through blending of a synthetic polymer, polycaprolactone (PCL), and a natural one, gelatin (GT), using an electrospinning technique. Bicomponent of polycaprolactone/gelatin (PCL/GT) nanofibers was successfully formed by using acetic acid/formic acid (AA/FA) solvent system. In the present study the working parameters were studied to understand the conversion of polymer solutions into nanofibers through electrospinning. Various experimental parameters, such as solution ...
Tópico(s): Conducting polymers and applications
2019 - IOP Publishing | Advances in Natural Sciences Nanoscience and Nanotechnology
Hesham Abdel‐Hady, Samia Hawas, Medhat A. El-Daker, R.I. El-Kady,
Tópico(s): Antibiotic Resistance in Bacteria
2023 - Springer Nature | Journal of Perinatology
Osama Ramadan, Ahmed A. Damanhory, EZZ ELDIN E. ABD ALLAH, Tamer Albasyoni Gomah, Mohammed E. Mahmoud, FATMA M. ABD ALLAH, Haitham M. Sewilam, REDA M.A. FAYYAD, MEDHAT M. DARWISH, Fahaid Al- Hashem, Moaaz M. Y. Awad, Mahmoud Diab, TAYEE E. M, Magdy Y. Elseed, ALSAYED A. ABDEL HADY,
Diabetes mellitus is a worldwide epidemic causes numerous health problems including nephropathy and depression which are caused by oxygen radicals.We investigated the antioxidative effects of agomelatine or vildagliptin on streptozotocin-induced diabetic nephropathy in rats.50 male albino rats were distributed into five groups, (n = 10/ group): the normal control, A single intraperitoneal injection of streptozotocin was given to the other four groups to induce diabetes at a dose of 60 mg/kg body weight. ...
Tópico(s): Circadian rhythm and melatonin
2024 - | Journal of Research in Pharmacy