Haruo Takaku, Megumi Takase, Shin‐ichiro Abe, Hideya Hayashi, Kaoru Miyazaki,
Arginine deiminase (EC 3.5.3.6) was purified to homogeneity from the cell extract of Mycoplasma arginini by molecular-sieve, anion-exchange and arginine-affinity chromatographies. The purified enzyme was composed of 2 identical sub-units with a molecular weight of 45.000 and had a pI of 4.7. Its Vmax value and Km value for L-arginine were estimated to be 50 units/mg protein and 0.2 mM, respectively. It exerted maximal enzyme activity at pH 6.0-7.5 and at 50 degrees C. The arginine deiminase was stable ...
Tópico(s): Enzyme function and inhibition
1992 - Wiley | International Journal of Cancer
Yasuhiro Yamamoto, Kenkichi Takase, Junji Kishino, Megumi Fujita, Noboru Okamura, Toshiyuki Sakaeda, Masafumi Fujimoto, Tatsurou Yagami,
15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is one of factors contributed to the neurotoxicity of amyloid β (Aβ), a causative protein of Alzheimer's disease. Type 2 receptor for prostaglandin D2 (DP2) and peroxysome-proliferator activated receptorγ (PPARγ) are identified as the membrane receptor and the nuclear receptor for 15d-PGJ2, respectively. Previously, we reported that the cytotoxicity of 15d-PGJ2 was independent of DP2 and PPARγ, and suggested that 15d-PGJ2 induced apoptosis through the novel ...
Tópico(s): Alzheimer's disease research and treatments
2011 - Public Library of Science | PLoS ONE
Hirobumi Teraoka, Megumi Mikoshiba, Kozo Takase, Kohtaro Yamamoto, Kinji Tsukada,
We have previously found that dimethyl sulfoxide (DMSO), a known inducer of differentiation in several kinds of myeloid cells, arrests proliferation of human lymphoid cells including Raji and Akata Burkitt's lymphoma cells at the G1 phase. We investigated whether DMSO affects cell proliferation and differentiation of the lymphoid cell line SKW6-CL4, which is capable of differentiating terminally into IgM-producing cells. As in the case of Raji, Akata, and Molt-4, the proliferation of SKW6-CL4 was ...
Tópico(s): T-cell and B-cell Immunology
1996 - Elsevier BV | Experimental Cell Research
Yusuke Narita, Kiyoshi Okamoto, Megumi Ikemori Kawada, Kazuma Takase, Yukinori Minoshima, Kotaro Kodama, Masao Iwata, Norimasa Miyamoto, Kohei Sawada,
Many clinical cases of acquired resistance to the BRAF inhibitor vemurafenib have recently been reported. One of the causes of this acquired resistance is the BRAF downstream kinase point mutation MEK1-C121S. This mutation confers resistance to not only vemurafenib, but also to the allosteric MEK inhibitor selumetinib (AZD6244). Here, we investigated the pharmacologic activities and effectiveness of the novel MEK inhibitor E6201 against BRAF (v-raf murine sarcoma viral oncogene homolog B1)-V600E mutant ...
Tópico(s): Cancer Mechanisms and Therapy
2014 - American Association for Cancer Research | Molecular Cancer Therapeutics
Yasuhiro Yamamoto, Kenkichi Takase, Junji Kishino, Megumi Fujita, Noboru Okamura, Toshiyuki Sakaeda, Masafumi Fujimoto, Tatsurou Yagami,
15-deoxy-D 12,14 -prostaglandin J 2 (15d-PGJ 2 ) is one of factors contributed to the neurotoxicity of amyloid b (Ab), a causative protein of Alzheimer's disease.Type 2 receptor for prostaglandin D 2 (DP2) and peroxysome-proliferator activated receptorc (PPARc) are identified as the membrane receptor and the nuclear receptor for 15d-PGJ 2 , respectively.Previously, we reported that the cytotoxicity of 15d-PGJ 2 was independent of DP2 and PPARc, and suggested that 15d-PGJ 2 induced apoptosis through the novel ...
Tópico(s): S100 Proteins and Annexins
2011 - Public Library of Science | PLoS ONE
Marni J. Falk, Xiaowu Gai, Megumi Shigematsu, Elisa Vilardo, Ryuichi Takase, Elizabeth M. McCormick, Thomas Christian, Emily Place, Eric A. Pierce, Mark Consugar, Howard Gamper, Walter Rossmanith, Ya‐Ming Hou,
We report a Caucasian boy with intractable epilepsy and global developmental delay. Whole-exome sequencing identified the likely genetic etiology as a novel p.K212E mutation in the X-linked gene HSD17B10 for mitochondrial short-chain dehydrogenase/reductase SDR5C1. Mutations in HSD17B10 cause the HSD10 disease, traditionally classified as a metabolic disorder due to the role of SDR5C1 in fatty and amino acid metabolism. However, SDR5C1 is also an essential subunit of human mitochondrial RNase P, ...
Tópico(s): Mitochondrial Function and Pathology
2016 - Taylor & Francis | RNA Biology
Tomoki Takase, Hiroaki Ikesue, Haruna Nakagawa, Megumi Kinoshita, Nobuyuki Muroi, Takeshi Kitai, Yutaka Furukawa, Tohru Hashida,
Edoxaban is used to prevent and treat stroke or systemic embolism such as venous thromboembolism. Although bleeding is the most common complication of anticoagulants, only a few studies have addressed the safety of direct oral anticoagulants in East Asian patients. In this study, we investigated the risk factors for bleeding in Japanese patients receiving edoxaban. A retrospective review of the records of 198 patients who received 30 mg/d edoxaban in our hospital between April 2015 and March 2017 ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2019 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Kazuaki Yakushiji, Hisashi Gondo, Kenjiro Kamezaki, K Shigematsu, Shin Hayashi, Megumi Kuroiwa, Shuichi Taniguchi, Yoshinori Ohno, Kei Takase, Akihiko Numata, Kohei Aoki, Koji Kato, Koji Nagafuji, Kazuya Shimoda, Takayuki Okamura, Naoko Kinukawa, Naoki Kasuga, M Sata, M Harada,
Tópico(s): Immune Cell Function and Interaction
2002 - Springer Nature | Bone Marrow Transplantation
Iwao Takase, Hiroshi MITAMURA, Megumi HISAMATSU, Hiroshi Aida, Hisashi Kohkame,
α-メチルスチレン (MS) とアクリロニトリル (AN) のコポリマー鎖にN-フェニルマレイミド (PMI) またはN-P-クロロフェニルマレイミド (CPMI) を3～17mol%導入した5種のMS-AN-PMI及びMS-AN-CPMIターポリマーをそれぞれ合成した. 得られたターポリマーの熱的性質に及ぼすPMI及びCPMI組成の影響を検討した結果, PMI及びCPMI組成の増加に従ってガラス転移温度 (Tg), 軟化温度 (Tsoft), 及び熱分解開始温度 (Td) が著しく上昇することを認めた. これより耐熱性に優れる環構造のマレイミド単位をMS-ANコポリマー鎖に適量導入することによりコポリマーの熱的性質を必要に応じて改善できることが明らかとなった.
Tópico(s): Advanced Polymer Synthesis and Characterization
1990 - Society of Polymer Science | KOBUNSHI RONBUNSHU
Kazunori Ikebukuro, Megumi Takase, Koji Sode,
We screened DNA aptamers against the water-soluble quinoprotein glucose dehydrogenase (PQQGDH) with a competitive selection method. PQQGDH is a dimeric enzyme that consists of 50-kDa subunits, and has high catalytic activity for glucose (about 5000 U/mg), therefore is used for glucose sensors in the market. PQQGDH is an excellent molecular recognition device for biosensor for diagnosis. The SELEX was performed using a competitive selection method which enables us to select aptamer having high specificity ...
Tópico(s): Molecular Junctions and Nanostructures
2007 - Oxford University Press | Nucleic Acids Symposium Series
Tomoki Takase, Hiroaki Ikesue, Haruna Nakagawa, Megumi Kinoshita, Nobuyuki Muroi, Takeshi Kitai, Yutaka Furukawa, Tohru Hashida,
What is known and objective Edoxaban has three dose adjustment factors (creatinine clearance, 15-50 mL/min; body weight, 60 kg or less; and concomitant medication with potent P-glycoprotein inhibitors) to prevent bleeding that results from elevated blood concentrations of the drug. A dose reduction (from 60 to 30 mg/day of edoxaban) is recommended for patients with even one of those. However, it is not clear whether 30 mg/day of edoxaban is adequate for patients with multiple dose adjustment factors. ...
Tópico(s): Heparin-Induced Thrombocytopenia and Thrombosis
2019 - Wiley | Journal of Clinical Pharmacy and Therapeutics
Sachiko MORIUCHI, Setsuko YOSHIZAWA, Norimasa HOSOYA, Sachiko Takase, Megumi Otani,
ニワトリの発達過程における, 十二指腸粘膜の脂質組成の変化を観察してみた。その結果, コレステロール, トリグリセリドには孵化前後で有意な変化は観察されなかったが, リン脂質ならびに総脂肪酸量は, 孵化後有意な増大をしめした。さらに脂肪酸組成は, 孵化の前後で著明な変化を示した。孵化後, 16: 0, 18: 1などが減少し, 長鎖多不飽和脂肪酸の増加の傾向が観察された。
Tópico(s): Diet, Metabolism, and Disease
1977 - Japan Society of Nutrition and Food Science | Eiyo to shokuryo/Eiyo To Shokuryo
Tsutomu Yasukawa, Peter Wiedemann, A. Takase, Akiko Nishiwaki, Megumi Hirata, Johannes Kacza, Yousef Yafai, Wd. Eichler, Johannes Seeger, Yuichiro Ogura,
Tópico(s): Retinal Diseases and Treatments
2007 - Cadmus Press | Investigative Ophthalmology & Visual Science
Yasuhiro Yamamoto, Kenkichi Takase, Megumi Fujita, Noboru Okamura, Toshiyuki Sakaeda, Tatsurou Yagami,
Tópico(s): Eicosanoids and Hypertension Pharmacology
2011 - Elsevier BV | Neuroscience Research
Kazuhiko Shibata, Hiromi Urakami, Noriko Kawakami, Misae Takase, Megumi Ishikura, Youko Maeda, Ikuko Akae,
当医療圏では，在宅医主導で，PCA（patient-controlled analgesia）ポンプを使用して疼痛緩和を行うための連携システムが構築されておらず，在宅でオピオイド持続注射を実施することが困難であった．在宅緩和ケア中に内服困難となった乳がん患者に対して，病院緩和ケアチームが協力しオピオイド持続皮下注を開始した症例の経験と，医師会在宅医グループ勉強会での討論を踏まえ，システムの検討を行った．その結果，1）オピオイドは在宅医が処方，2）がん性疼痛看護認定看護師が訪問看護師に同行し，患者宅でアセスメントし，薬液を交換，3）ポンプレンタルは在宅医，消耗品は病院が負担，4）在宅医が在宅悪性腫瘍患者指導管理料，病院が共同指導管理料・訪問看護指導料をそれぞれ算定，というシステム「在宅PCAらくらくパック」を構築した．約2年間で6例の患者にこのシステムを適用した．システムを利用した在宅医，訪問看護ステーションにアンケート調査を行い，おおむね有益であるとの評価を得た．
Tópico(s): Opioid Use Disorder Treatment
2015 - Japanese Society for Palliative Medicine | Palliative Care Research
Atsushi Kinoshita, Hirotaka Takuma, Maki Hino, Yumiko Kaji, Toshifumi Kubo, Azusa Takase, Megumi Yahara, Junichi Higuchi,
Tópico(s): Pharmacy and Medical Practices
2022 - Japanese Society of Pharmaceutical Health Care and Sciences | Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
Yusuke Narita, Kiyoshi Okamoto, Megumi Ikemori Kawada, Kazuma Takase, Yukinori Minoshima, Kotaro Kodama, Masao Iwata,
... Suppl):A289. Citation Format: Yusuke Narita, Kiyoshi Okamoto, Megumi Ikemori Kawada, Kazuma Takase, Yukinori Minoshima, Kotaro Kodama, Masao Iwata. Novel ATP- ...
Tópico(s): Cancer Mechanisms and Therapy
2013 - American Association for Cancer Research | Molecular Cancer Therapeutics
Satoko Ohfuji, Masaaki Deguchi, Daisuke Tachibana, Masayasu Koyama, Toshiyuki Takagi, Takayuki Yoshioka, Akinori Urae, Kazuya Ito, Tetsuo Kase, Akiko Maeda, Kyoko Kondo, Wakaba Fukushima, Yoshio Hirota, Shiro Imai, E Akagaki, Mariko Akai, Y. Azuma, Shinichi Hamada, Satoru Motoyama, Hiroko Chimori, Shoko Nakagawa, Takehiko Fukuda, Masahisa Hagiwara, H. Okuda, Takuro Hamanaka, Seiichi Yamamasu, Kenji Hirota, Masataka Oku, Keizo Hiramatsu, Masanori Hisamatsu, Yasushi Iijima, Mikio Takehara, Somei Ikeda, Takeshi Inoue, Eriko Yamashita, Aisaku Fukuda, I. Iwata, Junko Nishio, Tateki Tsutsui, Kenji Yamaji, Takao Kamiya, Atsushi Kasamatsu, Tatsuya Nakajima, K Kasahara, Kenjitsu Kasamatsu, Kawabata Ryoichi, Kazume Kawabata, Kozo Kadowaki, Hiroshi Nomura, Tomoyuki Kikuchi, Ayako Suzuki, Tadayoshi Nagano, Yoshitsugu Komeda, R. Kondo, Shinjin Konishi, Hideo Takemura, Masako Kasumi, Kazuo Masuhiro, Ryoji Ito, Yoshiki Sakamoto, Kouzo Hirai, Yoshimitsu Yamamoto, Yoshitaka Kariya, O. Misaki, Akira Miyake, Yasuko Osako, Masao Mori, Keizo Naka, Y Tokura, Jun Yoshimatsu, Keiji Tatsumi, Takayoshi Kanda, Masahiro Nishikawa, Sekio Nishimoto, Yoshihiro Nishioka, Takao Funato, Kouichi Nozaki, Gengo Ohira, Yoshiyuki Okamura, Yuzo Oga, Osamu Nakamoto, Shinichi Nakata, Tetsuo Nakamura, Masahiko Takemura, Toshiyuki Sadou, Nobuaki Mitsuda, Daisuke Fujita, Koji Hisamoto, Shinobu Akada, Takafumi Nonogaki, Chinami Horiuchi, Yasuhiko Shiki, Tadashi Kimura, K. Kitamura, Kazuhide Ogita, Shigeki Matsuo, Yoshihito Ikeda, Akihiro Moriyama, Yukiyoshi Ishikawa, Hiroshi Muso, Fuminori Kitada, Toshiya Yamamoto, Megumi Takemura, Takeshi Sawada, Kentaro Shimura, K. Shinyashiki, Mitsuhiko Masuda, Tsuneo Shoda, Takamichi Nishizaki, Yoshinori Suzuki, Isao Suzuki, Hiroshi Nanjyo, K. Takabatake, Kikuya Takase, Satoshi Nakago, Jun Takeyama, Takeshi Taniguchi, Keiichi Tasaka, Toshiaki Tatsumi, Atsushi Tokuhira, Shogo Tsubokura, Kayoko Ueda, Yukiko Uenae, T Unno, Hiroshi Yabuki, Tokihiro Yanamoto, Yoshihiko Yamada, Nobuyuki Maruo, Yoshitsugu Takada,
Infants <6 months of age are too young to receive influenza vaccine, despite being at high risk for severe influenza-related complications.To examine the effectiveness of maternal influenza vaccination in preventing influenza in their infants, we conducted a prospective cohort study of 3441 infants born at participating hospitals before the 2013-2014 influenza season. At the time of recruitment, their mothers completed a questionnaire about influenza vaccination status for the 2013-2014 season. A ...
Tópico(s): Neuroscience of respiration and sleep
2017 - Oxford University Press | The Journal of Infectious Diseases
Etsuro Mori, Manabu Ikeda, Eizo Iseki, Sadao Katayama, Yasuhiro Nagahama, Megumi Ohdake, Takao Takase,
Abstract Background Donepezil has been approved in Japan for the treatment of dementia with Lewy bodies (DLB) based on clinical trials showing its beneficial effects on cognitive impairment. This phase IV study evaluated the efficacy of donepezil by focusing on global clinical status during a 12‐week double‐blind phase. Methods Patients with probable DLB were randomly assigned to the placebo ( n = 79) or 10 mg donepezil ( n = 81) groups. The primary endpoint was changes in global clinical status, assessed ...
Tópico(s): Schizophrenia research and treatment
2024 - Wiley | Psychogeriatrics
Aki Takase, Akihiro Hamuro, Megumi Ashimura, Natusko Yokoi, Takuya Misugi, Daisuke Tachibana, Masayasu Koyama,
Among surgical procedures of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, the laparoscopic Davydov's technique seems to offer the most feasible and effective approach for creating a neovagina. Several reports have pointed at the necessity for mobilization of the peritoneum to obtain a longer neovagina and have reported a modified laparoscopic Davydov’s method. A new method was performed for a 24- and an 18-year-old patient. The most significant method in present procedure was to leave the thickened ...
Tópico(s): Uterine Myomas and Treatments
2018 - Medip Academy | International Journal of Reproduction Contraception Obstetrics and Gynecology
Taisuke Ikawa, Kaito Fujita, Shota Kiuchi, Muhang Li, Atsuhito Kushima, Hayato Takase, Bratati Das, Megumi Morita, Hiroyuki Todo, Miles Pennington, Kaori Sugihara,
Polypropylene mesh, integrated in N95 respirators and surgical masks that are widely used in the current crisis of COVID-19, filters aerosols via electrostatics in addition to the physical block. However, any contact to water such as storage under high humidity, exposure to exhaling breath, and washing in water removes its charges and thus compromises its filtering efficiency. We developed a desk top device based on a Cockcroft-Walton's voltage multiplier that can restore the electrostatic charge ...
Tópico(s): Climate Change and Health Impacts
2023 - Elsevier BV | Heliyon
Produção Nacional
Revisado por pares
Shoji Miwa, Megumi Nakamura, Michiko OKUNO, Hisako Miyazaki, Jun Watanabe, Yuko Ishikawa-Takano, Makoto Miura, Nao Takase, Sachio Hayakawa, Shôichi Kobayashi,
A starch ingredient with antioxidative activity, as measured by the DPPH method, was produced by baking corn starch with an organic acid; it has been named ANOX sugar (antioxidative sugar). The baking temperature and time were fixed at 170 °C and 60 min, and the organic acid used was selected from preliminary trials of various kinds of acid. The phytic acid ANOX sugar preparation showed the highest antioxidative activity, but the color of the preparation was almost black; we therefore selected L-tartaric ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2011 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Takayuki Kimura, Noboru Yamamoto, Hiroshi Kamiyama, Megumi Ikemori Kawada, Akihiko Yamamoto, Yoshihiko Kotake, Yasutaka Takase, Yasuhiro Funahashi, Yoshiya Oda,
... Citation Format: Takayuki Kimura, Noboru Yamamoto, Hiroshi Kamiyama, Megumi Ikemori Kawada, Akihiko Yamamoto, Yoshihiko Kotake, Yasutaka Takase, Yasuhiro Funahashi, Yoshiya Oda. Chemical probe-based approach ...
Tópico(s): Cancer-related Molecular Pathways
2015 - American Association for Cancer Research | Cancer Research
N. Takeda, Megumi Maeda, Satsuki Itano, Miho Takase, Mariko Kimura, Yoshinobu Kimura,
In the present study, for the discovery of uncharacterized glycan-binding receptors or lectin-like receptors in plants, we developed neoglycopolymers to which three types of N-glycopeptides are conjugated; the first with plant complex type N-glycan (M3FX), the second with high-mannose type N-glycan (M8), and the third with animal complex type N-glycan (NeuAc2Gal2GN2M3). Three types of Asn-oligosaccharide (Asn-M3FX, Asn-M8, or Asn-NeuAc2Gal2GN2M3) were prepared from storage glycoproteins of Ginkgo biloba ...
Tópico(s): Transgenic Plants and Applications
2019 - Elsevier BV | International Journal of Biological Macromolecules
Megumi Hirata, Tsutomu Yasukawa, Peter Wiedemann, Erika Kimura, Noriyuki Kunou, Wolfram Eichler, A. Takase, Rina Sato, Yuichiro Ogura,
Tópico(s): Glaucoma and retinal disorders
2009 - Springer Science+Business Media | Graefe s Archive for Clinical and Experimental Ophthalmology
Masahito Hagio, Megumi Matsumoto, Michihiro Fukushima, Hiroshi Hara, Satoshi Ishizuka,
... 1683Google Scholar, 3Uchida K. Nomura Y. Kadowaki M. Takase H. Takano K. Takeuchi N. Age-related changes ... PDF PubMed Google Scholar, 4Satoh T. Uchida K. Takase H. Nomura Y. Takeuchi N. Bile acid synthesis ...
Tópico(s): Liver Disease Diagnosis and Treatment
2008 - Elsevier BV | Journal of Lipid Research
Tomohiro Yoshida, Takuya Misugi, Ryo Uemura, Megumi Hudaba, Aki Takase, Mie Tahara, Akihiro Hamuro, Akemi Nakano, Daisuke Tachibana, Masayasu Koyama,
2019 - Elsevier BV | Placenta
Ryoji Naganuma, Ichiro Yabe, Megumi Takeuchi, Kirari Morishita, Shingo Nakane, Ryoken Takase, Ikuko Takahashi‐Iwata, Masaaki Matsushima, Mika Otsuki, Hideaki Shiraishi, Hidenao Sasaki,
Studies on evoked responses in Parkinson's disease (PD) may be useful for elucidating the etiology and quantitative evaluation of PD. However, in previous studies, the association between evoked responses and detailed motor symptoms or cognitive functions has not been clear. This study investigated the characteristics of the visual (VEF), auditory (AEF), and somatosensory (SEF) evoked magnetic fields in patients with Parkinson's disease (PD), and the correlations between evoked fields and the patient' ...
Tópico(s): EEG and Brain-Computer Interfaces
2020 - Public Library of Science | PLoS ONE
Atsushi Tanaka, Masataka Sata, Yosuke Okada, Hiroki Teragawa, Katsumi Eguchi, Michio Shimabukuro, Isao Taguchi, Kazuo Matsunaga, Yumiko Kanzaki, Hisako Yoshida, Tomoko Ishizu, Shinichiro Ueda, Masafumi Kitakaze, Toyoaki Murohara, Koichi Node, Koichi Node, Toyoaki Murohara, Masafumi Kitakaze, Yoshihiko Nishio, Teruo Inoue, Mitsuru Ohishi, Kazuomi Kario, Masataka Sata, Michio Shimabukuro, Wataru Shimizu, Hideaki Jinnouchi, Isao Taguchi, Hirofumi Tomiyama, Koji Maemura, Makoto Suzuki, Shin‐ichi Ando, Katsumi Eguchi, Haruo Kamiya, Tomohiro Sakamoto, Hiroki Teragawa, Mamoru Nanasato, Munehide Matsuhisa, Junya Ako, Yoshimasa Aso, Masaharu Ishihara, Kazuo Kitagawa, Akira Yamashina, Tomoko Ishizu, Yumi Ikehara, Shinichiro Ueda, Ayako Takamori, Atsushi Tanaka, Miki Mori, Kaori Yamaguchi, Machiko Asaka, Tetsuya Kaneko, Masashi Sakuma, Shigeru Toyoda, Takahisa Nasuno, Michiya Kageyama, Teruo Jojima, Toshie Iijima, Haruka Kishi, Hirotsugu Yamada, Kenya Kusunose, Daiju Fukuda, Shusuke Yagi, Koji Yamaguchi, Takayuki Ise, Yutaka Kawabata, Akio Kuroda, Yuichi Akasaki, Mihoko Kurano, Satoshi Hoshide, Takahiro Komori, Tomoyuki Kabutoya, Yukiyo Ogata, Yuji Koide, Hiroaki Kawano, Satoshi Ikeda, Satoki Fukae, Seiji Koga, Yukihito Higashi, Shinji Kishimoto, Masato Kajikawa, Tatsuya Maruhashi, Yoshiaki Kubota, Yoshisato Shibata, Nehiro Kuriyama, Ikuko Nakamura, Kanemitsu Hironori, Bonpei Takase, Yuichi Orita, Chikage Oshita, Yuko Uchimura, Ruka Yoshida, Yukihiko Yoshida, Hirohiko Suzuki, Yasuhiro Ogura, Mayuho Maeda, Masaki Takenaka, Takumi Hayashi, Mirai Hirose, Itaru Hisauchi, Toshiaki Kadokami, Ryô Nakamura, Junji Kanda, Kazuo Matsunaga, Masaaki Hoshiga, Koichi Sohmiya, Yumiko Kanzaki, Arihiro Koyosue, Hiroki Uehara, Naoto Miyagi, Toshiya Chinen, Kentaro Nakamura, Chikashi Nago, Suguru Chiba, Sho Hatano, Yoshikatsu Gima, Masami Abe, Masayoshi Ajioka, Hiroshi Asano, Yoshihiro Nakashima, Hiroyuki Osanai, Takahiro Kanbara, Yusuke Sakamoto, Mitsutoshi Oguri, Shiou Ohguchi, Kunihiko Takahara, Kazuhiro Izumi, Kenichiro Yasuda, Akihiro Kudo, Noritaka Machii, Ryota Morimoto, Yoshiyuki Bando, Takahiro Okumura, Toru Kondo, Shin‐ichiro Miura, Yuhei Shiga, Joji Mirii, Makoto Sugihara, Tadaaki Arimura, Junko Nakano, Tomohiro Sakamoto, Kazuhisa Kodama, Nobuyuki Ohte, Tomonori Sugiura, Kazuaki Wakami, Yasuhiko Takemoto, Minoru Yoshiyama, Taichi Shuto, Kazuo Fukumoto, Yosuke Okada, Kenichi Tanaka, Satomi Sonoda, Akemi Tokutsu, Takashi Otsuka, Fumi Uemura, Kenji Koikawa, Megumi Miyazaki, Maiko Umikawa, Manabu Narisawa, Machi Furuta, Hiroshi Minami, M. Doi, Kazuhiro Sugimoto, Susumu Suzuki, Akira Kurozumi, Kosuke Nishio,
Abstract Aims To examine the effects of a 24-month treatment with ipragliflozin on carotid intima-media thickness (IMT) in type 2 diabetes patients. Methods and results In this multicenter, prospective, randomized, open-label, and blinded-endpoint investigator-initiated clinical trial, adults with type 2 diabetes and haemoglobin A1C (HbA1c) of 6.0–10.0% (42–86 mmol/mol) were randomized equally to ipragliflozin (50 mg daily) and non-sodium-glucose cotransporter-2 (SGLT2) inhibitor use of standard-care ( ...
Tópico(s): Regulation of Appetite and Obesity
2022 - Oxford University Press | European Heart Journal - Cardiovascular Pharmacotherapy
Koshiro Kanaoka, Kenji Onoue, Satoshi Terasaki, Tomoya Nakano, Michikazu Nakai, Yoko Sumita, Kinta Hatakeyama, Fumio Terasaki, Rika Kawakami, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Yoshihiko Saito, Satoshi Yuda, Masaya Tanno, Toru Takahashi, Hisashi Yokoshiki, Masahiro Toba, Toshihisa Anzai, Toshiyuki Nagai, Takuma Sato, Takashi Takenaka, Seiji Yamazaki, Yuki Katagiri, Toshiharu Takeuchi, Kazuya Sugitatsu, Shigeo Kakinoki, Tomoaki Matsumoto, Kazushi Urasawa, Michinao Tan, Ichizo Tsujino, Mitsunori Kamigaki, Hirofumi Tomita, Kenji Hanada, Motoi Kushibiki, Akihiro Nakamura, Yoshihiro Morino, Takahito Nasu, Satoshi Yasuda, Hideaki Suzuki, Kaoru Iwabuchi, Kanako Tsuji, Shigeto Namiuchi, Tatsuya Komaru, Masahiro Yagi, Shoko Uematsu, Toshiaki Takahashi, Satoru Takeda, Toru Nakanishi, Masafumi Watanabe, Masahiro Wanezaki, Motoyuki Matsui, Shigeo Sugawara, Yasuchika Takeishi, Masayoshi Oikawa, Nobuo Komatsu, Satoshi Suzuki, Hiroaki Okamoto, Noriyuki Takeyasu, Daiki Akiyama, Yutaka Eki, Tsunekazu Kakuta, Tomoyo Sugiyama, Tomomi Koizumi, Koji Ueno, Kazuomi Kario, Mizuri Taki, Yuri Matsumoto, Takanori Yasu, Osamu Nishioka, Shigeto Naito, Makoto Murata, Shoichi Tange, Katsumi Kaneko, Makoto Muto, Hiroshi Inagaki, Shuichi Hasegawa, Eizo Tachibana, Wataru Atsumi, Masahiro Suzuki, Toshihiro Muramatsu, Yoshihiro Yamada, Isao Taguchi, Yoshiaki Fukuda, Akihiro Matsui, Junji Kanda, Koji Hozawa, Akihiko Matsumura, Wataru Shimizu, Takeshi Yamamoto, Issei Komuro, Masaru Hatano, Takanori Ikeda, Shunsuke Kiuchi, Taishiro Chikamori, Yasuyoshi Takei, Kyoko Soejima, Toshinori Minamishima, Hiroyuki Tanaka, Shigeo Shimizu, Masashi Kasao, Tadayuki Kadohira, Tohru Minamino, Kazunori Shimada, Hiroshi Iwata, Yukihiko Momiyama, Takashi Ashikaga, Toshihiro Nozato, Yasumasa Fujiwara, Kenji Inoue, Tetsuo Sasano, Junji Matsuda, Yasuhiro Ishii, Yuichi Ono, Kengo Tanabe, Yu Horiuchi, Toshiro Shinke, Yusuke Kodama, Masao Moroi, Y Yazaki, Taisuke Mizumura, Hiroshi Ohta, Yoshihiro J. Akashi, Nozomi Kotoku, Yuji Ikari, Mitsunori Maruyama, Yasuhiro Sato, Koichi Tamura, Masaaki Konishi, Hiroshi Suzuki, Mio Ebato, Kazuki Fukui, Kazuhiko Yumoto, Takamasa Iwasawa, Takeshi Kashimura, Kazuyoshi Takahashi, Yoshinobu Okada, Bunji Kaku, Kazuo Usuda, Michiro Maruyama, Tomoki Kameyama, Toshinori Higashikata, Akihiko Hodatsu, Kazuo Osato, Yoji Nagata, Koji Maeno, Kazuo Satake, Takao Sawanobori, Noboru Watanabe, Koichiro Kuwahara, Hirohiko Motoki, Hiroshi Kitabayashi, Kyuhachi Otagiri, Tsunesuke Kono, Daisuke Yamagishi, Yoshikazu Yazaki, Toshiyuki Noda, Itsuro Morishima, Naoki Watanabe, Shinichiro Tanaka, Tomoya Onodera, Ryuzo Nawada, Akinori Watanabe, Masaki Matsunaga, Satoru Suwa, Hiroshi Sakamoto, Hiroki Sakamoto, Takeshi Aoyama, Norio Kanamori, Masahiro Muto, Yuichiro Maekawa, Hayato Ohtani, Yukio Ozaki, Kenshin Naruse, Kenji Takemoto, Haruo Kamiya, Takeshi Suzuki, Yasushi Tomita, Susumu Suzuki, Ryosuke Kametani, Hidekazu Aoyama, Hiroyuki Osanai, Ken Harada, Kenji Kada, Tomoaki Saeki, Koichi Kobayashi, Yasuhiro Ogawa, Akihiro Terasawa, Masanori Shinoda, Mitsutoshi Oguri, Kiyokazu Shimizu, Akinori Sawamura, Atsushi Sugiura, Kosuke Hattori, Shinji Mokuno, Kazuhisa Kondo, Kaoru Dohi, Keishi Moriwaki, Atsunobu Kasai, Tetsuya Nakakuki, Kazuaki Kaitani, Toshikazu Jinnai, Takashi Yamamoto, Hiroyuki Kurata, Atsuyuki Wada, Masaharu Akao, Yasuhiro Hamatani, Kazuya Ishibashi, Yoshiki Akakabe, Yasuhide Asaumi, Hideo Matama, Yasushi Sakata, Hidetaka Kioka, Hiroshi Takaishi, Yoshitaka Iwanaga, Toru Takase, Mitsuo Matsuda, Fumi Sato, Shinji Hasegawa, Kenichi Ishigami, Minoru Ichikawa, Takashi Takagi, Moriaki Inoko, Masaaki Hoshiga, Shuichi Fujita, Takeda Yoshihiro, Takahiko Kawarabayashi, Hideyuki Takaoka, Kenji Nakajima, Tadashi Yuguchi, Tatsuya Kawasaki, Yukinori Shinoda, Yukihito Sato, Masaharu Ishihara, Yuki Matsumoto, Hiroya Kawai, Tomofumi Takaya, Kouki Matsuo, Toshiaki Mano, Ken–ichi Hirata, Eriko Hisamatsu, Nobutaka Inoue, Koichi Tamita, N Mukohara, Hisashi Shimoyama, Toru Miyajima, Toshihiro Tamura, Yodo Tamaki, Megumi Suzuki, Ryoji Yokota, Manabu Horii, Kazuo Yamanaka, Hiroyuki Kawata, Yukihiro Hashimoto, Yasuki Nakada, Hitoshi Nakagawa, Tomoya Ueda, Taku Nishida, Ayako Seno, Makoto Watanabe, Takashi Akasaka, Takashi Tanimoto, Mamoru Toyofuku, Kazuhiro Yamamoto, Yoshiharu Kinugasa, Masayuki Hirai, Hiroshi Nasu, Kinya Shirota, Tsuyoshi ODA, Takefumi Oka, Kazushige Kadota, Masanobu Ohya, Hiroshi Ito, Kazufumi Nakamura, Soichiro Ogura, Soichiro Fuke, Shiro Uemura, Hiromi Matsubara, Atsuyuki Watanabe, Nobuyuki Morishima, Kihara Yasuki, Takayuki Hidaka, Hironori Ueda, Yujiro Ono, Yuji Muraoka, Miyo Hatanari, Yoshinori Miyamoto, Keigo Dote, Masaya Kato, Masafumi Yano, Mamoru Mochizuki, Yasuhiro Ikeda, Hiroyuki Fujinaga, Shinobu Hosokawa, Masataka Sata, Koji Yamaguchi, Naoko Aki,
Fulminant myocarditis presentation (FMP) is a rare and severe presentation of myocarditis. The natural history of FMP and its clinical features associated with poor outcomes are incompletely understood because there is a lack of generalizable evidence.This multicenter retrospective cohort study included patients hospitalized with histologically proven myocarditis who underwent catecholamine or mechanical support from 235 cardiovascular training hospitals across Japan between April 2012 and March ...
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