Golnaz Khakpour, Arash Pooladi, Pantea Izadi, Mehrdad Noruzinia, Javad Tavakkoly‐Bazzaz,
Breast cancer is the most common malignancy among women worldwide. Risk assessment is one of the main services delivered by cancer clinics. Biomarker analysis on different tissues including the peripheral blood can provide crucial information. One of the potential epigenetic biomarkers (epimarkers) is introduced as the peripheral blood DNA methylation pattern. This study was conducted to evaluate the potential value of peripheral blood epimarkers as an accessible tool to predict the risk of breast ...
Tópico(s): RNA modifications and cancer
2015 - SAGE Publishing | Tumor Biology
Mehrdad Hashemi, Mehdi Pooladi, Solmaz Khaghani-Razi-Abad,
Angiogenesis performs a critical role in the development of cancer. Angiogenesis research is a cutting-edge field in cancer research. Proteomics is a powerful tool in identifying multiple proteins that are altered following a neuropharacological intervention in a disease of the central nervous system. Diagnostic oncoproteomics is the application of proteomic techniques for the diagnosis of malignancies.We extracted proteins of tumor and normal brain tissues and then evaluated the protein purity ...
Tópico(s): MRI in cancer diagnosis
2014 - BioMed Central | Journal of Cancer Research and Therapeutics
Solmaz Khaghani-Razi-Abad, Mehdi Pooladi, Mehrdad Hashemi, Afshin Moradi, Sara Sobhi, Alireza Zali, Masoumea Mousavi, Hakimeh Zali, Mona Zamanian Azodi, Azadeh Rakhshan, Reza Vafaee, Mostafa Rezaei‐Tavirani,
Background: Oligodendrogliomas are sub-types of Gliomas with an enriched net of branching capillary. A vast amount of Oligodendroglial (approximately 60-90%) demonstrates a loss of 1p and 19q chromosomes, and their response to radio and chemotherapy treatments are considerably more favorable and less aggressive. Rho GDP inhibitor is a protein which controls the activity and distribution of GTPase in cells. In cancer cells with 1pLOH deletion, Rho GDP inhibitor protein can be anti-apoptotic. Here ...
Tópico(s): Cell Image Analysis Techniques
2013 - Shahid Beheshti University of Medical Sciences | Iranian Journal of Cancer Prevention
Mehrdad Hashemi, Mehdi Pooladi, S. Eslami Jamal Abad,
INTRODUCTION: Proteomics is increasingly employed in both neurological and oncological research, and applied widely in every area of neuroscience research including brain cancer. Astrocytomas are the most common glioma and can occur in most parts of the brain and occasionally in the spinal cord. Patients with high-grade astrocytomas have a life expectancy of <1 year even after surgery, chemotherapy, and radiotherapy. MATERIALS AND METHODS: We extracted proteins from tumors and normal brain tissues ...
Tópico(s): Ubiquitin and proteasome pathways
2014 - Medknow | Indian Journal of Cancer
Solmaz Khaghani-Razi-Abad, Mehrdad Hashemi, Mehdi Pooladi, Maliheh Entezari, E. Kazemi,
Proteomics analyses enable the identification and quantitation of proteins. From a purely clinical perspective, the application of proteomics based on innovations, may greatly affect the future management of malignant brain tumors. This optimism is based on four main reasons: diagnosis, prognosis, selection of targeted therapy based on molecular profile of the brain tumor and monitoring therapeutic response, or resistance. We extracted the proteins of tumor and normal brain tissues, and then evaluated ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2015 - Elsevier BV | Gene
Mehrdad Mesgarpour, Massoud Mir, Rasool Alizadeh, Javad Mohebbi Najm Abad, Ehsan Pooladi Borj,
Thermal management is an important factor in extending the battery's life time and ensuring the quality of the output current. A numerical evaluation of the effect of varying the configuration of the battery cells and liquid-cooled channels was conducted in this case study. For the first time, a physics-informed neural network is coupled with visual tracking and commercial software for prediction of the thermal behaviour of a battery package. Combination of physics-informed neural network and visual ...
Tópico(s): Fuel Cells and Related Materials
2022 - Elsevier BV | Journal of Energy Storage
H. Pooladi, Mehrdad Moradi, E. Masoudipour,
Tópico(s): Poisoning and overdose treatments
2019 - OMICS Publishing Group | Journal of Forensic Medicine
Mehdi Pooladi, Mehrdad Hashemi, Saeed Hesami Tackallou, Soheila Karani,
Background: Tubulin is known as a heterodimer protein, which includes alpha and beta tubulin subunits. This structural protein plays important roles in pathogenesis and healing different diseases. Biomarkers help in fast and accurate detection of cancer. Proteomic studies can be useful both in biological and clinical research, also help obtain protein expression profiles by using twodimensional electrophoresis, mass spectrometry, and bioinformatics tools. Finding candidate proteins as cancer biomarkers ...
Tópico(s): Advanced Proteomics Techniques and Applications
2019 - Shahid Beheshti University of Medical Sciences | International Clinical Neuroscience Journal
Mehdi Pooladi, Maliheh Entezari, Mehrdad Hashemi,
Proteome indicates the protein content of a genome.Proteome analysis is effective in a new system formulation and prediction, prevention, and treatment based on protein.One of the purposes of proteomics researches is to know and understand the cancer mechanism.In this study, we separated the proteins by the Two-Dimensional Electrophorese method and analyzed and compared protein spots by statistical and software data.The spots were separated and identifi ed by the proteins' Isoelectric PH differences, ...
Tópico(s): Genetics, Bioinformatics, and Biomedical Research
2020 - AEPress | Bratislavské lekárske listy/Bratislava medical journal