Vidhya M. Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, Jan Kückelhaus, Lea Vollmer, Jonathan M. Goeldner, Simon P. Behringer, Florian Scherer, Melanie Boerries, Marie Follo, Tobias Weiß, Daniel Delev, Julius M. Kernbach, Pamela Franco, Nils Schallner, Christine Dierks, Maria Stella Carro, Ulrich Hofmann, Christian Fung, Roman Sankowski, Marco Prinz, Jürgen Beck, Henrike Salié, Bertram Bengsch, Oliver Schnell, Dieter Henrik Heiland,
Despite recent advances in cancer immunotherapy, certain tumor types, such as Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti-tumor immune response. Here we show, by applying an in-silico multidimensional model integrating spatially resolved and single-cell gene expression data of 45,615 immune cells from 12 tumor samples, that a subset of Interleukin-10-releasing HMOX1
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2022 - Nature Portfolio | Nature Communications
Andreas N. Schüring, Tanja Fehm, Karolin Behringer, Maren Goeckenjan, Pauline Wimberger, Melanie Henes, Jörg Henes, Martin F. Fey, Michael von Wolff,
Most guidelines about fertility preservation are predominantly focused on scientific evidence, but are less practically orientated. Therefore, practically oriented recommendations are needed to support the clinician in daily practice. A selective literature search was performed based on the clinical and scientific experience of the authors, focussing on the most relevant diseases and gynaecological cancers. This article (Part I) provides information on topics that are essential for the fertility ...
Tópico(s): Ovarian function and disorders
2017 - Springer Science+Business Media | Archives of Gynecology and Obstetrics
Samantha Lee, Melanie Yap, Gregory Behringer, Richard Hung, Joan W. Bennett,
Many Trichoderma species are applied as biofungicides and biofertilizers to agricultural soils to enhance crop growth. These filamentous fungi have the ability to reduce plant diseases and promote plant growth and productivity through overlapping modes of action including induced systemic resistance, antibiosis, enhanced nutrient efficiency, and myco-parasitism. Trichoderma species are prolific producers of many small metabolites with antifungal, antibacterial, and anticancer properties. Volatile ...
Tópico(s): Nematode management and characterization studies
2016 - BioMed Central | Fungal Biology and Biotechnology
Vidhya M. Ravi, Kevin Joseph, Julian Wurm, Simon P. Behringer, Nicklas W. C. Garrelfs, Paolo d ́Errico, Yashar Naseri, Pamela Franco, Melanie Meyer‐Luehmann, Roman Sankowski, Mukesch Shah, Irina Mader, Daniel Delev, Marie Follo, Jürgen Beck, Oliver Schnell, Ulrich Hofmann, Dieter Henrik Heiland,
When it comes to the human brain, models that closely mimic in vivo conditions are lacking. Living neuronal tissue is the closest representation of the in vivo human brain outside of a living person. Here, we present a method that can be used to maintain therapeutically resected healthy neuronal tissue for prolonged periods without any discernible changes in tissue vitality, evidenced by immunohistochemistry, genetic expression, and electrophysiology. This method was then used to assess glioblastoma ( ...
Tópico(s): Glioma Diagnosis and Treatment
2019 - | Life Science Alliance
Vidhya M. Ravi, Paulina Will, Jan Kueckelhaus, Na Sun, Kevin Joseph, Henrike Salié, Lea Vollmer, Ugnė Kuliešiūtė, Jasmin von Ehr, Jasim Kada Benotmane, Nicolas Neidert, Marie Follo, Florian Scherer, Jonathan M. Goeldner, Simon P. Behringer, Pamela Franco, Mohammed Khiat, Junyi Zhang, Ulrich Hofmann, Christian Fung, Franz Ricklefs, Katrin Lamszus, Melanie Boerries, Manching Ku, Jürgen Beck, Roman Sankowski, Marius Schwabenland, Marco Prinz, Ulrich Schüller, Saskia Killmer, Bertram Bengsch, Axel Walch, Daniel Delev, Oliver Schnell, Dieter Henrik Heiland,
Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved transcriptomics, metabolomics, and proteomics. By deciphering regionally shared transcriptional programs across patients, we infer that glioblastoma is organized by spatial segregation of lineage ...
Tópico(s): Cell Image Analysis Techniques
2022 - Cell Press | Cancer Cell
Victor O. Oria, Peter Bronsert, Andreas Thomsen, Melanie Christine Föll, C. Zamboglou, Luciana Hannibal, Simon P. Behringer, Martin L. Biniossek, Cleopatra Schreiber, Anca‐Ligia Grosu, Louisa Bolm, Dirk Rades, Tobias Keck, Martin Werner, Ulrich F. Wellner, Oliver Schilling,
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis with frequent post-surgical local recurrence. The combination of adjuvant chemotherapy with radiotherapy is under consideration to achieve a prolonged progression-free survival (PFS). To date, few studies have determined the proteome profiles associated with response to adjuvant chemoradiation. We herein analyzed the proteomes of primary PDAC tumors subjected to additive chemoradiation after surgical resection and achieving short PFS (median ...
Tópico(s): Pancreatic function and diabetes
2018 - Elsevier BV | Translational Oncology
... 1016/j.cub.2017.09.013Jana A. Eccard, Melanie Dammhahn, Hannu Ylönen The Bruce effect revisited: is pregnancy termination in female rodents an adaptation to ensure breeding success after male turnover in low densities?, Oecologia 185, no.11 (Aug 2017): 81–94.https://doi.org/10.1007/s00442-017-3904-6Verena Behringer, Tobias Deschner Non-invasive monitoring of physiological markers ...
Tópico(s): Primate Behavior and Ecology
1979 - University of Chicago Press | The American Naturalist
Yonathan Freund, Mélanie Roussel, Wilhelm Behringer,
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) ...
Tópico(s): Cardiac tumors and thrombi
2021 - American Medical Association | JAMA Cardiology
Produção Nacional
Revisado por pares
Claire Hoencamp, Olga Dudchenko, Ahmed M.O. Elbatsh, Sumitabha Brahmachari, Jonne A. Raaijmakers, Tom van Schaik, Ángela Sedeño Cacciatore, Vinícius G. Contessoto, Roy G. H. P. van Heesbeen, Bram van den Broek, Aditya N. Mhaskar, Hans Teunissen, Brian Glenn St Hilaire, David Weisz, Arina D. Omer, Melanie Pham, Zane Colaric, Zhenzhen Yang, Suhas S.P. Rao, Namita Mitra, Christopher Lui, Weijie Yao, Ruqayya Khan, Leonid L. Moroz, Andrea B. Kohn, Judy St. Leger, Alexandria Mena, Karen Holcroft, Maria Cristina Gambetta, Fabian Lim, Emma K. Farley, Nils Stein, Alexander F. Haddad, Daniel Chauss, Ayse Sena Mutlu, Meng C. Wang, Neil D. Young, Evin Hildebrandt, Hans H. Cheng, Christopher J. Knight, Theresa L.U. Burnham, Kevin A. Hovel, Andrew J. Beel, Pierre-Jean Mattei, Roger D. Kornberg, Wesley C. Warren, Gregory A. Cary, José Luis Gómez-Skármeta, Veronica F. Hinman, Kerstin Lindblad‐Toh, Federica Di Palma, Kazuhiro Maeshima, Asha S. Multani, Sen Pathak, Liesl Nel‐Themaat, Richard R. Behringer, Parwinder Kaur, René H. Medema, Bas van Steensel, Elzo de Wit, José N. Onuchic, Michele Di Pierro, E Aiden, Benjamin D. Rowland,
We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this ...
Tópico(s): RNA and protein synthesis mechanisms
2021 - American Association for the Advancement of Science | Science
Mélanie Roussel, Ben Bloom, Mehdi Taalba, Christophe Choquet, Delphine Douillet, Florent Fémy, Alexis Marouk, Judith Gorlicki, Camille Gerlier, Richard Macrez, É. Arnaud, Rudy Bompard, Emmanuel Montassier, Olivier Hügli, Charlotte Czopik, Xavier Eyer, Axel Benhamed, Olivier Peyrony, Tahar Chouihed, Andréa Penaloza, Alessio Marra, Sai͏̈d Laribi, Paul Reuter, Wilhelm Behringer, Marion Douplat, Jérémy Guenezan, Nicolas Javaud, Olivier Lucidarme, Marine Cachanado, Ainhoa Aparicio-Monforte, Yonathan Freund, Mouna Berroukeche, Anthony Chauvin, Anne-Charlotte Dekeister, Mostafa El Hajjam, Sami Ellouze, O. Ganansia, Julien Grosjean, Quentin Le Bastard, Thomas Moumneh, Milan Najdawi, Laurent Pereira, Isabelle Piazza, Sarah Ponticello, Jason Pott, Clément Ricordeau, Julie Robert, Pascal Rousset, Imogen Skene, Clara Vignau, Youri Yordanov,
Background: Recently, validated clinical decision rules have been developed that avoid unnecessary use of computed tomographic pulmonary angiography (CTPA) in patients with suspected pulmonary embolism (PE) in the emergency department (ED). Objective: To measure any resulting change in CTPA use for suspected PE. Design: Retrospective analysis. Setting: 26 European EDs in 6 countries. Patients: Patients with CTPA performed for suspected PE in the ED during the first 7 days of each odd month between ...
Tópico(s): Radiation Dose and Imaging
2023 - American College of Physicians | Annals of Internal Medicine
Nicola-Hans Schwarzer, Noëlle Behringer, Paula Dees, Stephan Gingelmaier, Melanie Henter, Holger Kirsch, Tillmann F. Kreuzer, Robert Langnickel, Pierre-Carl Link, Sascha Müller, Agnes Turner, Peter Fonagy, Tobias Nolte,
Tópico(s): Attachment and Relationship Dynamics
2025 - Elsevier BV | Child Abuse & Neglect
Keyvan Razazi, Charles‐Édouard Luyt, Guillaume Voiriot, Anahita Rouzé, Marc Garnier, Alexis Ferré, Laurent Camous, Nicholas Heming, Nathanaël Lapidus, Anaïs Charles‐Nelson, Armand Mekontso‐Dessap, Alain Mercat, Pierre Asfar, François Beloncle, Julien Demiselle, Tài Pham, Arthur Pavot, Xavier Monnet, Christian Richard, Alexandre Demoule, Martin Dres, Julien Mayaux, Alexandra Beurton, Cédric Daubin, Richard Descamps, Aurélie Joret, Damien du Cheyron, Frédéric Pène, Jean‐Daniel Chiche, Mathieu Jozwiak, Paul Jaubert, Guillaume Voiriot, Muriel Fartoukh, Marion Teulier, Clarisse Blayau, Erwen L’Her, Cécile Aubron, Laetitia Bodénes, Nicolas Ferrière, Johann Auchabie, Anthony Le Meur, Sylvain Pignal, Thierry Mazzoni, Jean‐Pierre Quenot, Pascal Andreu, Jean-Baptiste Roudau, Marie Labruyère, Saad Nseir, Sébastien Preau, Julien Poissy, Daniel Mathieu, Sarah Benhamida, Rémi Paulet, Nicolas Roucaud, Martial Thyrault, Florence Daviet, Sami Hraiech, Gabriel Parzy, Aude Sylvestre, Sébastien Jochmans, Anne-Laure Bouilland, Mehran Monchi, Marc Danguy des Déserts, Quentin Mathais, Gwendoline Rager, Pierre Pasquier, Jean Reignier, Amélie Seguin, Charlotte Garret, Emmanuel Canet, Jean Dellamonica, Clément Saccheri, Romain Lombardi, Yanis Kouchit, Sophie Jacquier, Armelle Mathonnet, Mai-Ahn Nay, Isabelle Runge, Frédéric Martino, Laure Flurin, Amélie Rolle, Michel Carles, Rémi Coudroy, Arnaud W. Thille, Jean‐Pierre Frat, Maeva Rodriguez, Pascal Beuret, Audrey Tientcheu, Arthur Vincent, Florian Michelin, Fabienne Tamion, Dorothée Carpentier, Déborah Boyer, Christophe Girault, Valérie Gissot, Stéphan Ehrmann, Charlotte Salmon Gandonnière, Djlali Elaroussi, Agathe Delbove, Yannick Fédun, Julien Huntzinger, Eddy Lebas, Grâce Kisoka, Céline Gregoire, Stella Marchetta, Bernard Lambermont, Laurent Argaud, Thomas Baudry, Pierre-Jean Bertrand, Auguste Dargent, Christophe Guitton, Nicolas Chudeau, Mickaël Landais, Cédric Darreau, Alexis Ferré, Antoine Gros, Guillaume Lacave, Fabrice Bruneel, Mathilde Neuville, Jérôme Devaquet, Guillaume Tachon, Richard Gallot, Riad Chelha, Arnaud Galbois, Anne Jallot, Ludivine Chalumeau Lemoine, Khaldoun Kuteifan, Valentin Pointurier, Louise-Marie Jandeaux, Joy Mootien, Charles Damoisel, Benjamin Sztrymf, Matthieu Schmidt, Alain Combes, Juliette Chommeloux, Charles Edouard Luyt, Frédérique Schortgen, Leon Rusel, Camille Jung, Florent Gobert, Damien Vimpére, Lionel Lamhaut, Bertrand Sauneuf, Liliane Charrrier, Julien Calus, Isabelle Desmeules, Benoît Painvin, Jean-Marc Tadié, Vincent Castelain, Baptiste Michard, Jean-Étienne Herbrecht, Mathieu Baldacini, Nicolas Weiss, Sophie Demeret, Clémence Marois, Benjamin Rohaut, Pierre-Henri Moury, Anne-Charlotte Savida, Emmanuel Couadau, Mathieu Sèrié, Nica Alexandru, Cédric Bruel, Candice Fontaine, Sonia Garrigou, Juliette Courtiade Mahler, Maxime Leclerc, Michel Ramakers, Pierre Garçon, Nicole Massou, Ly Van Vong, Juliane Sen, Nolwenn Lucas, Frank Chemouni, Annabelle Stoclin, Alexandre Avenel, Henri Faure, Angélie Gentilhomme, Sylvie Ricome, Paul Abraham, Céline Monard, Julien Textoris, Thomas Rimmelé, Florent Montini, Gabriel Lejour, Thierry Lazard, Isabelle Etienney, Younes Kerroumi, Claire Dupuis, Marine Bereiziat, Elisabeth Coupez, François Thouy, Clément Hofmann, Nicolas Donat, Anne Chrisment, Rose-Marie Blot, Antoine Kimmoun, Audrey Jacquot, Matthieu Mattei, Bruno Lévy, Ramin Ravan, Loïc Dopeux, Jean-Mathias Liteaudon, Delphine Le Roux, Brice Rey, Radu Anghel, Deborah Schenesse, Vincent Gevrey, Jermy Castanera, Philippe Petua, Benjamin Madeux, Otto Hartman, Michaël Piagnerelli, Anne Joosten, Cindérella Noel, Patrick Biston, Thibaut Noël, Gurvan Le Bouar, Messabi Boukhanza, Elsa Demarest, Marie-France Bajolet, Nathanaël Charrier, Audrey Quenet, Cécile Zylberfajn, Nicolas Dufour, Bruno Mégarbane, Sébastian Voicu, Nicolas Deye, Isabelle Malissin, François Legay, Matthieu Débarre, Nicolas Barbarot, Pierre Fillâtre, Bertrand Delord, Thomas Laterrade, Tahar Saghi, Wilfried Pujol, Pierre‐Julien Cungi, Pierre Esnault, Mickaël Cardinale, Vivien Hong Tuan Ha, Grégory Fleury, Marie-Ange Brou, Daniel Zafmahazo, David Tran-Van, Patrick Avargues, Lisa Carenco, Nicolas Robin, Alexandre Ouali, Lucie Houdou, Christophe Le Terrier, Noémie Suh, Steve Primmaz, Jérôme Pugin, Emmanuel Weiss, Tobias Gauss, Jean-Denis Moyer, Catherine Paugam Burtz, Béatrice La Combe, Rolland Smonig, Jade Violleau, Pauline Cailliez, Jonathan Chelly, Antoine Marchalot, Cécile Saladin, Christelle Bigot, Pierre-Marie Fayolle, Jules Fatséas, Amr Ibrahim, Dabor Résière, Rabih Hage, Clémentine Cholet, Marie Cantier, Pierre Trouiler, Philippe Montravers, Brice Lortat‐Jacob, Sébastien Tanaka, Alexy Tran‐Dinh, Jacques Duranteau, Anatole Harrois, Guillaume Dubreuil, Marie Werner, Anne Godiér, Sophie Hamada, Diane Zlotnik, Hélène Nougue, Armand Mekontso‐Dessap, Guillaume Carteaux, Keyvan Razazi, Nicolas de Prost, Nicolas Mongardon, Nicolas Mongardon, Meriam Lamraoui, Claire Alessandri, Quentin de Roux, Charles de Roquetaillade, Benjamin Chousterman,
... and General University Hospital in Prague, Czechia; Wilhelm Behringer, MD, MBA, MSc, Department of Emergency Medicine, Medical ...
Lippincott Williams & Wilkins
Mélanie Roussel, A. Aparicio-Montforte, W Hayman Behringer, O. Hugli, A. Marra, A. Penaloza, C. Choquet, D. Douillet, B. Bloom, Y. Freund,
BackgroundIn recent years, several clinical decision rules, including age-adjusted D-dimer threshold, PERC, YEARS, and PEGeD, have been derived to safely limit the use of computed tomographic pulmonary angiography (CTPA) in patients with suspected pulmonary embolism (PE) in the emergency department (ED). The hypothesis of this study is that this has led to a subsequent reduction in CTPA use.ObjectivesTo evaluate the temporal trend of CTPA use for suspected PE between 2015 and 2020. Method: This was ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2022 - Elsevier BV | Annals of Emergency Medicine
Vidhya M. Ravi, Paulina Will, Jan Kueckelhaus, Na Sun, Kevin Joseph, Henrike Salié, Lea Vollmer, Ugnė Kuliešiūtė, Jasmin von Ehr, Jasim Kada Benotmane, Nicolas Neidert, Marie Follo, Florian Scherer, Jonathan M. Goeldner, Simon P. Behringer, Pamela Franco, Mohammed Khiat, Junyi Zhang, Ulrich Hofmann, Christian Fung, Franz Ricklefs, Katrin Lamszus, Melanie Boerries, Manching Ku, Jürgen Beck, Roman Sankowski, Marius Schwabenland, Marco Prinz, Ulrich Schüller, Saskia Killmer, Bertram Bengsch, Axel Walch, Daniel Delev, Oliver Schnell, Dieter Henrik Heiland,
Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of the dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas in-depth by spatially resolved transcriptomics, metabolomics and proteomics. By deciphering regional shared transcriptional programs across patients, we infer that glioblastomas are organized by spatial segregation ...
Tópico(s): Single-cell and spatial transcriptomics
2021 - RELX Group (Netherlands) | SSRN Electronic Journal
Nicola-Hans Schwarzer, Noëlle Behringer, Paula Dees, Peter Fonagy, Stephan Gingelmaier, Melanie Henter, Joost Hutsebaut, Holger Kirsch, Tillmann F. Kreuzer, Robert Langnickel, Lisa A. Maier, Sascha Müller, Agnes Turner, Pierre-Carl Link, Tobias Nolte,
Tópico(s): Personality Disorders and Psychopathology
2025 - Springer Science+Business Media | Prävention und Gesundheitsförderung