Ana Paula Pereira Velosa, Walcy Rosólia Teodoro, Natalino Hajime Yoshinari,
... de componentes da matriz extracelular e destruição pelas metaloproteases, levando à degradação e perda do tecido cartilaginoso. ... da osteoartrose estaria na utilização de inibidores das metaloproteases associadas a condroprotetores interferindo no "turnover" da cartilagem ...
Tópico(s): Osteoarthritis Treatment and Mechanisms
2003 - Elsevier BV | Revista Brasileira de Reumatologia
... concentration 1.275 mg/ml).Whereas inhibitors of metaloproteases, chelating agents EDTA, had no effect on L- ... These finding suggest that L-asparaginase was not metaloproteases.
Tópico(s): Biological Research and Disease Studies
2015 - OMICS Publishing Group | Journal of Microbial & Biochemical Technology
Carmela Feingold, Rivka Bracha, A Wexler, David Mirelman,
... Protease inhibitors such as antitrypsin, pepstatin, phenylmethylsulfonyl fluoride, metaloprotease inhibitors, and bacitracin had no effect on the ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
1985 - American Society for Microbiology | Infection and Immunity
Makoto Otsuka, Junko Endo, Daisuke Hinode, Atsushi Nagata, Reiko MAEHARA, M. Sato, Ryô Nakamura,
... peaks, indicating that the enzyme is not a metaloprotease. Besides the enzymehydrolyzed synthetic substrates of trypsin, such ...
Tópico(s): Antimicrobial Peptides and Activities
1987 - Wiley | Journal of Periodontal Research
Abraham Kornberg, Suzana Kaufman, L. A. Silber, Jacob S. Ishay,
... the venom sac extract exhibits both serine and metaloprotease activities which may affect the activity of the ...
Tópico(s): Food Allergy and Anaphylaxis Research
1988 - Elsevier BV | Toxicon
A. Hugo Montes, Eulalia Valle-Garay, Victoria Álvarez, Marta Pevida, Eva García Pérez, José Paz, Álvaro Meana, Víctor Asensi,
... 9, -10, and -13) and tissue inhibitors of metaloproteases (TIMP-1, -2, and -4) in serum and ...
Tópico(s): Orthopaedic implants and arthroplasty
2009 - Oxford University Press | Journal of Bone and Mineral Research
Ysabel Santos, Isabel Bandı́n, Soledad Nún ̃ez, Manuel Montero, Alicia Silva, Alicia E. Toranzo,
... the existence of either or both serine and metaloproteases in the ECP of Vibrio and Aeromonas strains.
Tópico(s): Phytochemistry and Bioactivity Studies
1992 - Elsevier BV | Aquaculture
Maya Simionescu, Anca Violeta Gafencu, Felicia Antohe,
... indicate that transcytosis of albumin, low‐density lipoproteins, metaloproteases, and insulin, is performed by cargo‐vesicles and ...
Tópico(s): Blood properties and coagulation
2002 - Wiley | Microscopy Research and Technique
Produção Nacional
Revisado por pares
Paulo Emílio Corrêa Leite, Kessiane Belshoff de Almeida, Jussara Lagrota-Cândido, Pablo Trindade, Rafael Ferreira da Silva, Manuel Gustavo Leitão Ribeiro, Katia G. Lima‐Araújo, Wilson C. Santos, Thereza Quírico‐Santos,
... choline acetyltransferase and acetylcholinesterase enzymatic activities, but decreased metaloproteases‐9 and ‐2 activities and levels of tumor ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2010 - Wiley | Journal of Cellular Biochemistry
Nicholas J. Cowans, Anastasia Stamatopoulou, S. Jaakohuhta, Kevin Spencer,
Maternal serum A Disintergrin And Metaloprotease-12 (ADAM-12) has been proposed as a marker for prenatal screening of chromosomal abnormalities, pre-eclampsia and other adverse pregnancy ...
Tópico(s): Molecular Biology Techniques and Applications
2010 - Wiley | Prenatal Diagnosis
... C (PLC), protein kinase Cδ (PKCδ), and matrix metaloprotease-2 (MMP-2). Moreover, GαqQL mediated UVB-induced ...
Tópico(s): Cell Adhesion Molecules Research
2010 - Elsevier BV | Biochemical and Biophysical Research Communications
Lung fibrosis is the final common pathway of a large variety of chronic lung disorders, named interstitial lung diseases. The most aggressive form is the idiopathic pulmonary fibrosis [IPF] characterized by alveolar epithelial cell injury/activation, expansion of the fibroblast/myofibroblast population, and the exaggerated accumulation of extracellular matrix [ECM] components which ultimately result in the destruction of the lung parenchyma. Several matrix metalloproteases [MMPs] are upregulated in ...
Tópico(s): Peptidase Inhibition and Analysis
2012 - BioMed Central | Fibrogenesis & Tissue Repair
Christopher B. Cameron, Cory D. Bishop,
... 130 family, a carbonic anhydrase and a matrix metaloprotease are present and transcribed during the development of ...
Tópico(s): Marine Biology and Environmental Chemistry
2012 - Royal Society | Proceedings of the Royal Society B Biological Sciences
Produção Nacional
Revisado por pares
Fernando Lucas Primo, Leonardo Barcelos de Paula, Marigilson P. Siqueira-Moura, Antônio Cláudio Tedesco,
... model and the quantification of important macromolecules (as metaloproteases derivatives), related directly with wound healing process. Results ...
Tópico(s): Medical and Biological Ozone Research
2012 - Bentham Science Publishers | Current Medicinal Chemistry
... of von Willebrand factor cleaving protease (ADAMTS13), a metaloprotease involved in thrombotic thrombocytopenic purpura.J Biol Chem. ...
Tópico(s): Blood groups and transfusion
2004 - Elsevier BV | Journal of Thrombosis and Haemostasis
Anna Muszyńska, Jerzy Pałka, Ewa Gorodkiewicz,
... shown by western immunoblot analysis. Since prolidase is metaloprotease, requiring manganese for catalytic activity and anthracyclines are ...
Tópico(s): Neuropeptides and Animal Physiology
2000 - Elsevier BV | Experimental and Toxicologic Pathology
Mervat Morsy Abbas Ahmed El-Gendy,
... of cysteine protease (1, 10-phenanthroline and Dithiothreitol), metaloprotease (EDTA and EGTA) and thioprotease (iodoacetamide and p- ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2014 - OMICS Publishing Group | Journal of Microbial & Biochemical Technology
Barbara Sobotič, Matej Vizovišek, Robert Vidmar, Petra Van Damme, Vasilena Gocheva, Johanna A. Joyce, Kris Gevaert, Vito Türk, Boris Turk, Marko Fonovič,
... protease families, matrix metalloproteases (MMPs) and disintegrin-type metaloproteases (ADAMs), among which the best known is ADAM17 ( ...
Tópico(s): Advanced Proteomics Techniques and Applications
2015 - Elsevier BV | Molecular & Cellular Proteomics
Cody P. Coyne, Carla Willetto, Brad Fenwick,
... aspartate) peptidase cathepsin-D, which is a non-metaloprotease known to exert relatively limited proteolytic activity.
Tópico(s): Chemokine receptors and signaling
1999 - Lippincott Williams & Wilkins | Shock
Produção Nacional
Revisado por pares
Marcello Zaia Oliveira, Mauro Batista Albano, Guilherme Augusto Stirma, Mário Massatomo Namba, Leandro Vidigal, Luiz Antônio Munhoz da Cunha,
... marcadores imuno‐histoquímicos para pesquisa da quantidade de metaloproteases (MMPs‐3,13) e seus inibidores (TIMPs‐1, ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2017 - Thieme Medical Publishers (Germany) | Revista Brasileira de Ortopedia
Mohsen Sisakht, Baratali Mashkani, Ali Bazı, Ostadi Hassan, Maryam Zare, Farnaz Zahedi Avval, Hamid Reza Sadeghnia, Majid Mojarad, Mohammad Nadri, Ahmad Ghorbani, Mohmmad Soukhtanloo,
Glioblastoma is the most common malignant brain tumor representing with poor prognosis, therapy resistance and high metastasis rate. Increased expression and activity of matrix metalloproteinase-2, a member of matrix metalloproteinase family proteins, has been reported in many cancers including glioblastoma. Inhibition of matrix metalloproteinase-2 expression has resulted in reduced aggression of glioblastoma tumors in several reports. In the present study, we evaluated effect of bee venom on expression ...
Tópico(s): Tendon Structure and Treatment
2017 - Springer Science+Business Media | Revista Brasileira de Farmacognosia
Takashi Kaito, Shiro Ohshima, Hiroyasu Fujiwara, Takahiro Makino, Shota Takenaka, Yusuke Sakai, Hideki Yoshikawa,
... baseline (odds ratio [OR] = 9.23) and matrix metaloprotease-3 level at baseline (OR = 1.01) were ...
Tópico(s): Lymphoma Diagnosis and Treatment
2018 - Elsevier BV | Journal of Orthopaedic Science
Produção Nacional
Revisado por pares
Luciano Fusco, Emídio Beraldo-Neto, Áleff Ferreira Francisco, Jorge Alfonso, Andreimar M. Soares, Daniel C. Pimenta, Laura C. Leiva,
... low quantity (less than 1.5%), both enzymes (metaloprotease, phospholipase B and 5'-nucleotidase) and proteins (Bradykinin ...
Tópico(s): Biochemical and Structural Characterization
2020 - Elsevier BV | Toxicon X
Assaf R. Gavish, Orr H. Shapiro, Esti Kramarsky‐Winter, Assaf Vardi,
... coenosarc was followed by an increase in matrix metaloprotease activity, and subsequent increase in both pathogen and ...
Tópico(s): Aquaculture disease management and microbiota
2021 - Springer Nature | ISME Communications
Sivapriya Sivagurunathan, Lakshmi Dhevi N. Selvan, Aafaque Ahmad Khan, Sowmya Parameswaran, Harsha Bhattacharjee, Krishna Gogoi, Harsha Gowda, Thottethodi Subrahmanya Keshava Prasad, Akhilesh Pandey, Santosh Kumar, Pukhraj Rishi, Ekta Rishi, Dhanashree Ratra, Muna Bhende, Narayanan Janakiraman, Jyotirmay Biswas, Subramanian Krishnakumar,
... Alpha1 antitrypsin), TIMP-1 (Tissue inhibitor of matrix metaloprotease-1), APOA-1 (Apolipoprotein A-1) were significantly ...
Tópico(s): Retinal and Optic Conditions
2021 - Medknow | Indian Journal of Ophthalmology
Produção Nacional
Ana Paula de Souza, Paula Cristina Trevilatto, Alexandre Augusto Zaia, Sérgio Roberto Peres Line,
... estudo teve por objetivo analisar a expressão das metaloproteases da matriz extracelular durante a atrofia experimental das ... A confirmação de que as enzimas detectadas eram metaloproteases foi feita pelo uso de inibidores específicos. Os resultados sugerem que as metaloproteases da matriz têm um papel importante na remodelação ...
Tópico(s): Oral microbiology and periodontitis research
1999 - UNIVERSIDADE DE SÃO PAULO | Revista de Odontologia da Universidade de São Paulo
... penetrate the collagen matrix. The role of matrix metaloproteases in mammary duct branching morphogenesis is a well- ...
Tópico(s): Developmental Biology and Gene Regulation
2010 - American Physical Society | AJP Cell Physiology
Maysa A. I. Awadallah, Heba A. Ahmed, Abdallah M. A. Merwad, Rasha M.M. Abou Elez, Karem M.A. Saleh,
... of different origin, while gene encoding for zinc-metaloprotease (zpx) was only identified in isolates from animal ...
Tópico(s): Parasitic Infections and Diagnostics
2017 - Mary Ann Liebert, Inc. | Vector-Borne and Zoonotic Diseases
Maja Zakošek Pipan, M. Kosec, Janko Mrkun, Petra Zrimšek,
... semen indicators correlate with lower concentrations of these metaloproteases in seminal plasma. Gelatinases with molecular weight of ...
Tópico(s): Male Reproductive Health Studies
2010 - University of Veterinary and Pharmaceutical Sciences, Brno | Acta Veterinaria Brno
Metaloproteases such aa matrix metalloprotems (MMPa) and Astacin metalloproteaes (AMPs) have been propored to have an important ...
1993 - American Society for Cell Biology | Molecular Biology of the Cell