Luiza Jończak, Robert Pływaczewski, PAWEŁ ŚLIWIŃSKI, Michał Bednarek, Dorota Górecka, J Zieliński,
The question of whether upper airway resistance syndrome (UARS) is a distinct disease or an initial feature of obstructive sleep apnoea syndrome is still a matter of debate. We evaluated a retrospective group of UARS patients to determine the evolution of UARS over time and the relationship between clinical evolution and subjects' phenotype. Investigations were performed in 30 patients, in whom UARS was diagnosed between 1995 and 2000 by the use of full polysomnography (PSG) without oesophageal pressure ( ...
Tópico(s): Tracheal and airway disorders
2009 - Wiley | Journal of Sleep Research
Anna Jakubska-Busse, M. Śliwiński, Michał J. Kobyłka,
The contents and composition of essential oils obtained from Heracleum sosnowskyi and Heracleum mantegazzianum (Apiaceae) were examined. essential oils were investigated by the GC/MS method. The composition of hogweeds' essential oils was examined in order to determine toxic compounds that could have a direct influence on the health of people and animals living in close proximity to both species. It was found that the essential oils, except for derivatives of coumarins, contain numerous toxic compounds, ...
Tópico(s): Phytochemistry and Biological Activities
2013 - University of Belgrade, University of Novi Sad | Archives of Biological Sciences
Natalia Cichoń, Ewelina Synowiec, Elżbieta Miller, Tomasz Śliwiński, Michał Ceremuga, Joanna Saluk, Michał Bijak,
Apoptosis in acute stroke is associated with a negative prognosis and is correlated with the severity of the neurological deficit. However, there is no evidence that indicates that, in the subacute phase of the stroke, the apoptosis process might activate neuroplasticity. Therefore, in this study, we investigated the effect of an extremely low frequency electromagnetic field (ELF-EMF) on the molecular mechanism of apoptosis, as used in the rehabilitation of post-stroke patients. Patients with moderate ...
Tópico(s): Biofield Effects and Biophysics
2020 - Multidisciplinary Digital Publishing Institute | Brain Sciences
Anita Konieczna, Kamil Roman, Monika Roman, D. Śliwiński, Michał Roman,
The purpose of this work is to determine the impact of selected silage maize cultivation technologies, including energy inputs in the production chain (cultivation, harvesting, heap placing), on energy efficiency. The analysis of energy inputs, energy efficiency for the silage maize production technology were estimated. The research was performed for 13 farms producing silage maize. The data from the farms covered all the activities and the agrotechnical measures performed. The calculations of energy ...
Tópico(s): Forest Biomass Utilization and Management
2020 - Multidisciplinary Digital Publishing Institute | Energies
Tomasz Kowalczyk, Anna Merecz-Sadowska, Patrícia Rijo, Mattia Mori, Sophia Hatziantoniou, Karol Górski, Janusz Szemraj, Janusz Piekarski, Tomasz Śliwiński, Michał Bijak, Przemysław Sitarek,
Many of the anticancer agents that are currently in use demonstrate severe side effects and encounter increasing resistance from the target cancer cells. Thus, despite significant advances in cancer therapy in recent decades, there is still a need to discover and develop new, alternative anticancer agents. The plant kingdom contains a range of phytochemicals that play important roles in the prevention and treatment of many diseases. The Solanaceae family is widely used in the treatment of various ...
Tópico(s): Natural product bioactivities and synthesis
2022 - Multidisciplinary Digital Publishing Institute | Cancers
Edyta Janik, Michał Ceremuga, Marcin Niemcewicz, Ewelina Synowiec, Tomasz Śliwiński, Michał Bijak,
T-2 toxin is produced by different Fusarium species and belongs to the group of type A trichothecene mycotoxins. T-2 toxin contaminates various grains, such as wheat, barley, maize, or rice, thus posing a risk to human and animal health. The toxin has toxicological effects on human and animal digestive, immune, nervous and reproductive systems. In addition, the most significant toxic effect can be observed on the skin. This in vitro study focused on T-2 toxicity on human skin fibroblast Hs68 cell ...
Tópico(s): Plant Disease Resistance and Genetics
2023 - Multidisciplinary Digital Publishing Institute | Molecules
Anna Bielecka-Kowalska, Piotr Czarny, Paulina Wigner, Ewelina Synowiec, Bartosz Bielecki-Kowalski, Marzena Szwed, Renata Krupa, Monika M. Toma, Małgorzata Drzewiecka, Ireneusz Majsterek, Janusz Szemraj, Tomasz Śliwiński, Michał Kowalski,
Although methacrylic acid derivatives in their polymeric form are considered to be safe, insufficient polymerization and the release of monomers due to either mechanical or enzymatical factors can lead to their reaching millimolar concentrations in local tissue. The present study evaluates the effect of two methacrylate monomers - ethylene glycol dimethacrylate (EGDMA) and diethylene glycol dimethacrylate (DEGDMA) - on human gingival fibroblasts (HGFs). Both monomers were found to reduce cells viability ...
Tópico(s): Photodynamic Therapy Research Studies
2017 - Elsevier BV | Toxicology in Vitro
Angela Dziedzic, Agnieszka Morel, Elżbieta Miller, Michał Bijak, Tomasz Śliwiński, Ewelina Synowiec, Michał Ceremuga, Joanna Saluk,
The results of past research studies show that platelets are one of the main sources of reactive oxygen species (ROS) and reactive nitrogen species (RNS) to be found in the course of many pathological states. The aim of this study was to determine the level of oxidative/nitrative stress biomarkers in blood platelets obtained from multiple sclerosis (MS) patients ( n = 110 ) and to verify their correlation with the clinical parameters of the psychophysical disability of patients. The mitochondrial metabolism ...
Tópico(s): Traditional Chinese Medicine Analysis
2020 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
A. Jaworek, Artur Marchewicz, A. Krupa, A.T. Sobczyk, T. Czech, Teresa Antes, Łukasz Śliwiński, M. Kurz, Michał Szudyga, W Rożnowski,
Submicron and nanoparticles removal from flue or exhaust gases remain still a challenge for engineers. The most effective device used for gas cleaning in power plants or industry is electrostatic precipitator, but its collection efficiency steeply decreases for particles smaller than 1 micron. In this paper, fractional collection efficiency of two-stage electrostatic precipitator comprising of alternating electric field charger and DC supplied parallel-plate collection stage has been investigated. ...
Tópico(s): Icing and De-icing Technologies
2015 - IOP Publishing | Journal of Physics Conference Series
Edyta Janik, Michał Ceremuga, Magdalena Więckowska, Monika Szyposzyńska, Marcin Niemcewicz, Ewelina Synowiec, Tomasz Śliwiński, Michał Bijak,
T-2 toxin is produced by different Fusarium species, and it can infect crops such as wheat, barley, and corn. It is known that the T-2 toxin induces various forms of toxicity such as hepatotoxicity, nephrotoxicity, immunotoxicity, and neurotoxicity. In addition, T-2 toxin possesses a strong dermal irritation effect and can be absorbed even through intact skin. As a dermal irritant agent, it is estimated to be 400 times more toxic than sulfur mustard. Toxic effects can include redness, blistering, ...
Tópico(s): Bacillus and Francisella bacterial research
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Michał Ceremuga, Maksymilian Stela, Edyta Janik, Leslaw Gorniak, Ewelina Synowiec, Tomasz Śliwiński, Przemysław Sitarek, Joanna Saluk, Michał Bijak,
Bee venom is a very complex mixture produced and secreted by the honeybee (Apis mellifera). Melittin is a major component of bee venom that accounts for about 52% of its dry mass. A vast number of studies have been dedicated to the effects of melittin's regulation of apoptosis and to the factors that induce apoptosis in various types of cancer such as breast, ovarian, prostate, lung. The latest evidence indicates its potential as a therapeutic agent in the treatment of leukaemia. The aim of our present ...
Tópico(s): Bee Products Chemical Analysis
2020 - Multidisciplinary Digital Publishing Institute | Biomolecules
Ewelina Synowiec, Paulina Wigner, Natalia Cichoń, Cezary Watała, Piotr Czarny, Joanna Saluk, Elżbieta Miller, Tomasz Śliwiński, Ewa Zielińska-Nowak, Michał Bijak,
The present preliminary case-control study was undertaken to detect the potential association of six single nucleotide polymorphisms (SNPs) in oxidative stress-related genes: SOD2 (c.47T > C; rs4880), CAT (c.-89A > T; rs7943316), GPX4 (c.660T > A; rs713041), NOS1 (g.117803515C > T; rs1879417) and NOS2 (c.1823C > T; rs2297518 and c.-227G > C; rs10459953) and the occurrence of a stroke. The SNPs were determined using the TaqMan® Allelic Discrimination Assay in 107 patients with strokes and 107 age- and sex-matched ...
Tópico(s): Glutathione Transferases and Polymorphisms
2021 - Multidisciplinary Digital Publishing Institute | Brain Sciences
Tomasz Śliwiński, Paweł Ziemba, Zbigniew Morawiec, Michał Kowalski, Marek Zadrożny, Janusz Błasiak,
Tópico(s): Cancer-related Molecular Pathways
2006 - Springer Science+Business Media | Breast Cancer Research and Treatment
Ireneusz Majsterek, Tomasz Śliwiński, Tomasz Popławski, Dariusz Pytel, Michał Kowalski, Artur Słupianek, Tomasz Skórski, Janusz Błasiak,
Imatinib mesylate (STI571), a specific inhibitor of BCR/ABL tyrosine kinase, exhibits potent antileukemic effects in the treatment of chronic myelogenous leukemia (CML). However, the precise mechanism by which inhibition of BCR/ABL activity results in pharmacological responses remains unknown. BCR/ABL-positive human K562 CML cells resistant to doxorubicin (K562DoxR) and their sensitive counterparts (K562DoxS) were used to determine the mechanism by which the STI571 inhibitor may overcome drug resistance. ...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2006 - Elsevier BV | Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Janusz Lewiński, Michał Dutkiewicz, Michał Lesiuk, W. Sliwinski, Karolina Zelga, Iwona Justyniak, Janusz Lipkowski,
... plSearch for more papers by this authorMichał Lesiuk, Michał Lesiuk Department of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw (Poland), Fax: (+48) 22-234-7279 http://lewin.ch.pw.edu.plSearch for more papers by this authorDr. Witold Śliwiński, Dr. Witold Śliwiński Department of Chemistry, Warsaw University ... plSearch for more papers by this authorMichał Lesiuk, Michał Lesiuk Department of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw (Poland), Fax: (+48) 22-234-7279 http://lewin.ch.pw.edu.plSearch for more papers by this authorDr. Witold Śliwiński, Dr. Witold Śliwiński Department of Chemistry, Warsaw University ...
Tópico(s): Coordination Chemistry and Organometallics
2010 - Wiley | Angewandte Chemie International Edition
Janusz Lewiński, Michał Dutkiewicz, Michał Lesiuk, W. Sliwinski, Karolina Zelga, Iwona Justyniak, Janusz Lipkowski,
... plSearch for more papers by this authorMichał Lesiuk, Michał Lesiuk Department of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw (Poland), Fax: (+48) 22-234-7279 http://lewin.ch.pw.edu.plSearch for more papers by this authorDr. Witold Śliwiński, Dr. Witold Śliwiński Department of Chemistry, Warsaw University ... plSearch for more papers by this authorMichał Lesiuk, Michał Lesiuk Department of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw (Poland), Fax: (+48) 22-234-7279 http://lewin.ch.pw.edu.plSearch for more papers by this authorDr. Witold Śliwiński, Dr. Witold Śliwiński Department of Chemistry, Warsaw University ...
Tópico(s): Lanthanide and Transition Metal Complexes
2010 - Wiley | Angewandte Chemie
Natalia Cichoń, Joanna Saluk, Elżbieta Miller, Tomasz Śliwiński, Ewelina Synowiec, Paulina Wigner, Michał Bijak,
Activation of immunologically competent cells results in the overproduction of pro-inflammatory factors, and causes progression of nerve tissue damage. However, the potential neuroprotective effects of these factors in brain damage have not been well investigated.To evaluate the effect of extremely low frequency electromagnetic field (ELF-EMF) treatment on the molecular mechanism of inflammatory cytokine activity in post-stroke patients.All patients underwent the same rehabilitation program, but ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2019 - Foundation for Rehabilitation Information | Journal of Rehabilitation Medicine
Małgorzata Stańczyk, Tomasz Śliwiński, Magda Cuchra, Małgorzata Zubowska, Anna Bielecka-Kowalska, Michał Kowalski, Janusz Szemraj, Wojciech Młynarski, Ireneusz Majsterek,
Tópico(s): Epigenetics and DNA Methylation
2010 - Springer Nature | Molecular Biology Reports
Tomasz Kowalczyk, Anna Merecz-Sadowska, Mansour Ghorbanpour, Janusz Szemraj, Janusz Piekarski, Michał Bijak, Tomasz Śliwiński, Radosław Zajdel, Przemysław Sitarek,
The Lamiaceae is one of the most important families in the production of essential oils known to have a wide spectrum of biological activity. Recent research has highlighted the dermatological capabilities of various Lamiaceae essential oils, which appear to offer potential in free radical scavenging and anti-inflammatory activity. Some have also been extensively studied for their tissue remodeling and wound-healing, anti-aging, anti-melanogenic, and anti-cancer properties. Certain Lamiaceae essential ...
Tópico(s): Phytochemicals and Antioxidant Activities
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Tomasz Kowalczyk, Przemysław Sitarek, Anna Merecz-Sadowska, Monika Szyposzyńska, Aleksandra Spławska, Leslaw Gorniak, Michał Bijak, Tomasz Śliwiński,
It is known that Senna obtusifolia has been used in medicine since ancient times due to the content of many valuable compounds with a pro-health effect. One of them is betulinic acid, which is a pentacyclic triterpene with antimalarial, antiviral, anti-inflammatory and anticancer properties. In this work, a continuation of our previous research, an attempt was made to increase the level of betulinic acid accumulation by the cultivation of transgenic hairy roots that overexpress the squalene synthase ...
Tópico(s): Transgenic Plants and Applications
2021 - Multidisciplinary Digital Publishing Institute | Molecules
Michał Pióro, Tomasz Śliwiński, Michał Zagożdżon, Mateusz Dzida, Włodzimierz Ogryczak,
Link dimensioning and routing problems in resilient network design are considered. Reliable network operation is ensured by means of flow restoration which is performed on preselected protection (backup) paths that can absorb traffic overflows from failed primary paths. Backup and primary flows use separated link capacities, and can be split among many paths. In the paper, two restoration models are considered. The first model assumes that once the backup path is assigned it must be used in every ...
Tópico(s): Network Traffic and Congestion Control
2008 - Springer Science+Business Media | Lecture notes in computer science
Grzegorz Tchorek, Michał Brzozowski, Paweł Śliwiński,
Tópico(s): Banking stability, regulation, efficiency
2017 - Springer Science+Business Media | Portuguese Economic Journal
P. Górka, Bogdan Śliwiński, Jadwiga Flaga, J Olszewski, Marcin Wojciechowski, Klaudia Krupa, Michał M. Godlewski, R. Zabielski, Z.M. Kowalski,
Journal Article Effect of exogenous butyrate on the gastrointestinal tract of sheep. I. Structure and function of the rumen, omasum, and abomasum Get access Paweł Górka, Paweł Górka Department of Animal Nutrition and Dietetics, University of Agriculture in Krakow, Krakow, Poland Corresponding author: p.gorka@ur.krakow.pl https://orcid.org/0000-0002-4278-0493 Search for other works by this author on: Oxford Academic PubMed Google Scholar Bogdan Śliwiński, Bogdan Śliwiński Department of Animal Nutrition ...
Tópico(s): Animal Nutrition and Physiology
2018 - Oxford University Press | Journal of Animal Science
Natalia Cichoń, Piotr Czarny, Michał Bijak, Elżbieta Miller, Tomasz Śliwiński, Janusz Szemraj, Joanna Saluk,
Nitric oxide (NO) is one of the most important signal molecules, involved in both physiological and pathological processes. As a neurotransmitter in the central nervous system, NO regulates cerebral blood flow, neurogenesis, and synaptic plasticity. The aim of our study was to investigate the effect of the extremely low-frequency electromagnetic field (ELF-EMF) on generation and metabolism of NO, as a neurotransmitter, in the rehabilitation of poststroke patients. Forty-eight patients were divided ...
Tópico(s): Spaceflight effects on biology
2017 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
P. Prystawko, M. Leszczyński, A.A. Śliwiński, H. Teisseyre, T. Suski, Michał Boćkowski, S. Porowski, J. Z. Domagała, C. Kirchner, A. Pelzmann, M. Schauler, M. Kamp,
InxGa1−xN and AlxGa1−xN layers were grown by metalorganic chemical vapour deposition (MOCVD) on highly conductive single crystals of GaN. The samples were then examined using X-ray diffraction and photoluminescence. It was found that there is a substantial difference in properties between the layers grown on the N-face (00.{1}), chemically active, and Ga-face (00.1), chemically inert, sides. The latter layers had smaller free-electron concentration, better crystallographic quality and different chemical ...
Tópico(s): Ga2O3 and related materials
1999 - Elsevier BV | Journal of Crystal Growth
P. Górka, Bogdan Śliwiński, Jadwiga Flaga, J Olszewski, Paulina Nawrocka, Klaudyna Sobkowiak, Renata Miltko, Michał M. Godlewski, R. Zabielski, Z.M. Kowalski,
The aim of this study was to determine the effect of exogenous butyrate on the activity of carbohydrate-digesting enzymes in the reticuloruminal digesta and structure and selected functions of the small intestine in sheep. Eighteen rams (30.8 ± 2.1 kg; 12 to 15 mo of age) were fed for 14 d a diet without (CTRL) or with sodium butyrate (BUT; 36 g/kg of offered DM). Butyrate concentration in the reticuloruminal fluid and proximal small intestinal digesta was greater for BUT compared with CTRL (P ≤ 0.05). ...
Tópico(s): Animal Nutrition and Physiology
2018 - Oxford University Press | Journal of Animal Science
Paulina Wigner, Joanna Saluk, Ewelina Synowiec, Elżbieta Miller, Tomasz Śliwiński, Natalia Cichoń, Michał Bijak,
The abnormal activation of the tryptophan catabolites pathway (TRYCATs) is observed in patients suffering from cerebrovascular disease, including stroke. A previous study confirmed that lower bioavailability of tryptophan for serotonin synthesis was characterized in the patients during the acute stroke phase. Interestingly, according to various studies, polymorphisms of the genes involved in the TRYCATs pathway may modulate the risk of stroke occurrence. Therefore, this study aimed to investigate ...
Tópico(s): Neurological Disorders and Treatments
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Ireneusz Majsterek, Sliwinski Tomasz, Poplawski Tomasz, Pytel Dariusz, Kowalski Michal, Slupianek Artur, Tomasz Skórski, Blasiak Janusz,
2006 - Elsevier BV | Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Tomasz Śliwiński, Przemysław Sitarek, Ewa Skała, Vera M. S. Isca, Ewelina Synowiec, Tomasz Kowalczyk, Michał Bijak, Patrícia Rijo,
Plectranthus spp. is widely known for its medicinal properties and bioactive metabolites. The cytotoxic and genotoxic properties of the four known abietane diterpenoids: 7α-Acetoxy-6β-hydroxyroyleanone (Roy), 6,7-dehydroroyleanone (Deroy), 7β,6β-dihydroxyroyleanone6 (Diroy), and Parvifloron D (Parv), isolated from P. madagascariensis (Roy, DeRoy, and Diroy) and P. ecklonii (Parv) were evaluated. The tested compounds showed cytotoxic effects against the human leukemia cell line CCRF-CEM and the lung adenocarcinoma ...
Tópico(s): Natural product bioactivities and synthesis
2020 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Robert Pływaczewski, Przemysław Bieleń, Michał Bednarek, Luiza Jończak, Dorota Górecka, Paweł Śliwiński,
Obesity and male gender are the main risk factors for the development of obstructive sleep apnoea (OSA); however, some epidemiological data has shown that neck circumference (NC) > or = 43 cm is a better predictor of obstructive event frequency than body mass index (BMI). The aim of this study was to assess the relation between NC and BMI on OSA severity in males.The subjects completed a sleep questionnaire and Epworth sleepiness scale before the sleep study (full polysomnography or PolyMesam study). Authors ...
Tópico(s): Dysphagia Assessment and Management
2008 - | Advances in respiratory medicine