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... be eclipsed as consumers shop around Honda Cry Gof for Winston Monty and all those other heroes ... bigger share, says Alan Mitchell Media, Sales & Marketing Michael Page Sales & Marketing Multiple Classified Advertising Items Libel ...
1993 - Gale Group | TDA
... based performance, notably as founder-director of Brith Gof, while Michael Shanks is an archaeologist, specializing in the classical period and attempting ...
Tópico(s): Classical Antiquity Studies
2003 - Cambridge University Press | Theatre Survey
Charles De Freitas, Srikumar Sen, Boxing Correspondent, Victoria McKee, John Hurst, Frances Gibb, Legal Affairs Correspondent, Nicholas Wood, Political Correspondent, Christopher Warman, Property Correspondent, Daniel Ward, Motor Industry Correspondent, Patricia Davies, Andrew Morgan, Geoffrey Elcoat, D. L. Roberts, Robert Key, Carlo Comninos, Douglas Broom, Education Reporter, Michael Stevenson, George Vallings, Michael Seely, Racing Correspondent, Philip Howard, John Bell, City Editor, Denis Young, Ian Murray, Michael Binyon, Jeremy Kingston, Paul Vallely and Rodney Cowton, Mandarin (Michael Phillips), Carol Leonard, Srikumar Sen, Dessa Trevisan, Richard Streeton, Leslie Stobbs, Stuart Jones Football Correspondent, Roddy Forsyth, Colin Narbrough, Geoff Brown, Gerald Davies, Bernard Levin, K. L. J. Samengo-Turner, Lance Haward, Henry Gee, C. J. Doughty, Mitchell Platts, Golf Correspondent, Peter Davenport, Michael Tate, Peter Ball, Jill Sherman, Social Services Correspondent, D. G. Franklin, Louise Taylor, Lawrence Lever, Peter Ackroyd, Peter Waymark, Peter Bills, Alan Hamilton, Joe Joseph and Sam Kiley, David Smith Economics Correspondent, Thomson Prentice, Science Correspondent, A. W. Bullett, Walter Bodmer (Immediate Past-President), Charles Bremner, A. P. Mason, John Hennessy, John Young, Agriculture Correspondent, Martin Fletcher Political Reporter, Sam Kiley, Universities Reporter, Martin Winters, D. H. Reissner, D. M. A. Samengo-Turner, Harvey Elliott, Air Correspondent, Margaret Mackeith, Andrew Hislop, B. James, Rex Bellamy Tennis Correspondent, Harry Debelius, Wolfgang Munchau, Nicholas Harling, D. P. Barrie, Andrew Johnson, P. C. Metcalfe, Christopher Goulding, Robin Oakley, Political Editor, Kerry Gill, John F. Spellar, David Robinson, Peter Davalle, Nicholas Beeston, Raymond Keene, Chess Correspondent, Angela Rumbold, Paul Griffiths, Alexandra Jackson, Hugh Philbrick, Chairman, Sheila Gunn and John Young, Beryl Dixon, Conrad Voss Bark, Jamie Dettmer Irish Affairs Correspondent, Alan Kingshotte, Stewart Tendler, Crime Reporter, Irving Wardle, Ian Ross, Ronald Butt, David Sapsted, Richard Bassett, Sarah Jane Evans, David Brewerton, Christopher Thomas, Ian Smith, J. R. F. Samengo-Turner, Mandarin, Carol Ferguson, Clive White, A. Quick, Matthew Parris, Alan Franks, Sarah Jane Checkland Art Market Correspondent, Stephen B. Grant, Michael Clark and Geoffrey Foster, Malcolm MacIVER, Hazel Roberts, Mark W. J. Ferguson, David Walker, Lake Sagaris, Anthony Holden, Graham Searjeant, Alan Coren, Jonathan Meades, Dr Thomas Stuttaford, Mac Margolis, Rio de, David Tytler, Education Editor, Hugh and Phyllis Irwin, Derek Harris Industrial Editor, Philip Webster and Roland Rudd, Pearce Wright, Science Editor, T. A. Backhouse, G. C. Chapman, Commander, Colin Campbell, Tim Jones, Employment Affairs Correspondent, Angus Sinclair, John Smith, Chairman, Philip Jacobson, David Hands, Rugby Correspondent, Vivien Goldsmith, Family Money Editor, Andrew Moger and John Scammell, Tim Gardam, Editor, Dudley Wood, Secretary,
... a victory to remove his second-best tag Gof: Zimbabwean Aims to Gain Revenge against Ballesteros at ...
1988 - Gale Group | TDA
... theatre professionally, most notably with Welsh company Brith Gof (1981-97). He continues to create performances with Pearson/Brookes (1997-present) and National Theatre Wales (The Persians, 2010; Coriolan/us, 2012). He is co-author with Michael Shanks of Theatre/Archaeology: Disciplinary Dialogues (2001) and author of In Comes I: Performance, Memory and Landscape (2007), Site-specific Performance (2010), Mickery Theater: An Imperfect Archaeology (2011) and Marking Time: performance, archaeology ...
Tópico(s): Scottish History and National Identity
2013 - Taylor & Francis | Parallax
By BRIAN MACARTHUR, By DAVID WOOD, From INNIS MACBEATH, From MAX FRANKEL-Washington, May 8, BY OUR POLITICAL STAFF, From KYRIL TIDMARSH, By CLIVE BORRELL, By MICHAEL THOMAS, Labour Staff, By NORMAN FOWLER, Home Affairs Correspondent, FROM OUR CORRESPONDENT, BY OUR POLITICAL CORRESPONDENT, By BEVIS HILLIER-Sale Room Correspondent, By DAVID WILSWORTH, Broadcasting Correspondent, BY OUR PARLIAMENTARY STAFF, By ARTHUR REED, Air Correspondent, BY A STAFF REPORTER, By PHILIP HOWARD, By RONALD FAUX, By Nature-Times News Service, BY OUR EDUCATION CORRESPONDENT, BY OUR DIPLOMATIC STAFF, From DAVID BONAVIA-Saigon, May 8, FROM OUR OWN CORRESPONDENT-Paris, May 8, From IAN MCDONALD-Indianapolis, May 8, FROM OUR OWN CORRESPONDENT, FROM OUR OWN CORRESPONDENT-Rome, May 8, From CHARLES HARGROVE-Paris, May 8, From DESSA TREVISAN-Prague, May 8, From KYRIL TIDMARSH-Moscow, May 8, FROM OUR OWN CORRESPONDENT-Delhi, May 8, By GEOFFREY CHARLES, Motoring Correspondent, From Our Special Correspondent, FROM OUR CORRESPONDENT-Athens, May 8, FROM OUR CORRESPONDENT-Aden, May 8, By John Russell Taylor, by Michael Rosen, By Irving Wardle Drama Critic, By William Mann, D. MCV., by Terence Rattigan, By Henry Raynor, By Michael Billington, By CLIFFORD LONGLEY, PHS, DESMOND ACKNER, Chairman, General Council of the Bar of England and Wales., HARRY PLATT., J. C. SCOTT., F. E. JONES, Director, Service and Sales Department, Inland Telecommunications Headquarters, G.P.O., FRANK MARCUS., BEAUMONT OF WHITLEY., T. HUGHES ELLIS., By Marc Ullmann, Assistant Editor of L'Express, IRENE WARD., I. G. F. KARSTEN., BASIL LIDDELL HART., DAVID HARRIES, Chaplain, Royal Navy., PETER D. JOLLEY., From RAYMOND BROOKS-WARD-Rome, May 8, By PAMELA MACGREGOR-MORRIS, From GEOFFREY GREEN-Madrid, May 8, By NEIL ALLEN, Athletics Correspondent, By Our Real Tennis Correspondent, From REX BELLAMY, Tennis Correspondent-Rome, May 8, By JOHN WOODCOCK, Cricket Correspondent, By PETER CRANMER, By JIM SNOW, Northern Racing Correspondent, By Our Labour Staff, By MICHAEL BAILY, Shipping Correspondent, From DAVID SPANIER, U.S. Economics Correspondent, By MICHAEL HATFIELD, By DAVID DAVIS, By DAVID JONES, By Our Banking Correspondent, By RICHARD SPIEGELBERG, by Arthur Reed, Air Correspondent, by G. R. Wrixon, Technical Editor, Aeroplane, by Mark Lambert, by a Special Correspondent, by John Fricker, by John Bentley, Flight International, From HARLOW UNGER, New York, May 8, By Our Political Staff, BY THE FINANCIAL EDITOR, By RODNEY COWTON, FROM OUR CORRESPONDENT-New York, May 8, From PATRICIA LLOYD-JONES-Frankfurt, May 8, By GILLIAN O'CONNOR, By RONALD KERSHAW, DAVID TRENCH. Damory Cottage, Salisbury Road, Blandford, Dorset., By JOHN GILMORE,
... boosted Hoover profits, Good pace is set by GOF, Rank withdraws from TV rental, Copper, zinc and ...
1968 - Gale Group | TDA
Zihan Yan, Zeenat A. Shyr, Manuela Fortunato, Alecia Welscher, Mariana Alisio, Michael R. Martino, Brian N. Finck, Hannah Conway, Marı́a S. Remedi,
Aims To examine the effects of a high‐fat‐diet (HFD) on monogenic neonatal diabetes, without the confounding effects of compensatory hyperinsulinaemia. Methods Mice expressing K ATP channel gain‐of‐function (K ATP ‐GOF) mutations, which models human neonatal diabetes, were fed an HFD. Results Surprisingly, K ATP ‐GOF mice exhibited resistance to HFD‐induced obesity, accompanied by markedly divergent blood glucose control, with some K ATP ‐GOF mice showing persistent diabetes (K ATP ‐GOF‐non‐remitter [NR] ...
Tópico(s): Diabetes and associated disorders
2018 - Wiley | Diabetes Obesity and Metabolism
Emily S.J. Edwards, Julia Bier, Theresa Cole, Melanie Wong, Peter Hsu, Lucinda J. Berglund, Kaan Boztuğ, Anthony Lau, Emma Gostick, David A. Price, Michael O’Sullivan, Isabelle Meyts, Sharon Choo, Paul Gray, Steven M. Holland, Elissa K. Deenick, Gülbû Uzel, Stuart G. Tangye,
BackgroundGermline gain-of function (GOF) mutations in PIK3CD, encoding the catalytic p110δ subunit of phosphoinositide 3-kinase (PI3K), result in hyperactivation of the PI3K–AKT– ... required to understand disease in patients with PIK3CD GOF mutations, identify key molecules required for cell-mediated ... EBV-opathies.MethodsWe studied the consequences of PIK3CD GOF mutations on the generation, differentiation, and function of ... defense against infection with herpesviruses, including EBV.ResultsPIK3CD GOF total and EBV-specific CD8+ T cells were ...
Tópico(s): T-cell and B-cell Immunology
2018 - Elsevier BV | Journal of Allergy and Clinical Immunology
Pietro Fratta, Prasanth Sivakumar, Jack Humphrey, Kitty Lo, Thomas C. Ricketts, Hugo M. De Oliveira, J Armas, Bernadett Kalmár, Agnieszka M Ule, Yichao Yu, Nicol Birsa, Cristian Bodo, Toby Collins, Alexander E. Conicella, Alan Mejia Maza, Alessandro Marrero‐Gagliardi, Michelle Stewart, Joffrey Mianné, Silvia Corrochano, Warren Emmett, Gemma Codner, Michael J. Groves, Ryutaro Fukumura, Yoichi Gondo, Mark F. Lythgoe, Erwin Pauws, Emma Peskett, Philip Stanier, Lydia Teboul, Martina Hallegger, Andrea Calvo, Adriano Chiò, Adrian M. Isaacs, Nicolas L. Fawzi, Eric T. Wang, David E. Housman, Francisco E. Baralle, Linda Greensmith, Emanuele Buratti, Vincent Plagnol, Elizabeth Fisher, Abraham Acevedo‐Arozena,
... of function (LOF) and cytoplasmic gain of function (GOF) have been proposed to play a role (Ling ... the molecular effects of TDP-43 LOF and GOF in vivo in a physiological setting and in ... LCD) of TDP-43, which induces a splicing GOF. The analysis of this GOF uncovered entirely novel splicing events in genes not ... exons" (SE)—are skipped due to TDP-43 GOF. Remarkably, the skipping of constitutive exons induced by GOF is in contrast to the previously identified TDP- ... processes, our LCD mutant mouse strain with a GOF develops a progressive neuromuscular phenotype, in the absence ...
Tópico(s): Prion Diseases and Protein Misfolding
2018 - Springer Nature | The EMBO Journal
Jennifer W. Leiding, Satoshi Okada, David Hagin, Mario Abinun, Anna Shcherbina, Dmitry Balashov, Vy H.D. Kim, Adi Ovadia, Stephen L. Guthery, Michael A. Pulsipher, Desa Lilić, Lisa Devlin, Sharon Christie, Mark Depner, Sebastian Fuchs, Annet van Royen–Kerkhof, Caroline A. Lindemans, Aleksandra Petrović, Kathleen E. Sullivan, Nancy Bunin, Sara Şebnem Kılıç, Fikret Arpacı, Oscar De La Calle-Martin, Laura Martínez‐Martínez, Juan Carlos Aldave Becerra, Masao Kobayashi, Teppei Ohkawa, Kohsuke Imai, Akihiro Iguchi, Chaim M. Roifman, Andrew R. Gennery, Mary Slatter, Hans D. Ochs, Tomohiro Morio, Troy R. Torgerson,
BackgroundGain-of-function (GOF) mutations in signal transducer and activator of transcription 1 (STAT1) cause susceptibility to a range of infections, autoimmunity, immune ... the worldwide experience of HSCT in patients with GOF-STAT1 mutations and to assess outcomes, including donor ... from an international cohort of 15 patients with GOF-STAT1 mutations who had undergone HSCT using a ... the identified STAT1 variants was in fact a GOF mutation.ResultsPrimary donor engraftment in this cohort of 15 patients with GOF-STAT1 mutations was 74%, and overall survival was ...
Tópico(s): T-cell and B-cell Immunology
2017 - Elsevier BV | Journal of Allergy and Clinical Immunology
Kelsey Lane Warmbrod, Michael Montague, Gigi Kwik Grönvall,
... However, the meaning of "gain of function" or "GOF" in a science policy context has changed over ... Subsequent policies and discussions have attempted to define GOF in different ways, but no single definition has ... The fuzzy and imprecise nature of the term GOF has led to misunderstandings and has hampered discussions ... biosafety and biosecurity incidents prompted another examination of GOF work. In 2014, researchers at the CDC had ... Technology Policy to issue a funding pause on GOF studies involving influenza, MERS, and SARS. It only ...
Tópico(s): COVID-19 epidemiological studies
2021 - Springer Nature | EMBO Reports
Julia Bier, Geetha Rao, Kathryn Payne, Henry Brigden, Elise French, Simon J. Pelham, Anthony Lau, Helen Lenthall, Emily S.J. Edwards, Joanne Smart, Theresa Cole, Sharon Choo, Avni Y. Joshi, Roshini S. Abraham, Michael O’Sullivan, Kaan Boztuğ, Isabelle Meyts, Paul Gray, Lucinda J. Berglund, Peter Hsu, Melanie Wong, Steven M. Holland, Luigi D. Notarangelo, Gülbû Uzel, S. Cindy, Robert Brink, Stuart G. Tangye, Elissa K. Deenick,
BackgroundGain-of-function (GOF) mutations in PIK3CD cause a primary immunodeficiency characterized by recurrent respiratory tract infections, susceptibility to herpesvirus infections, and impaired ... production in both patients and mice. Furthermore, PIK3CD GOF human TFH cells had dysregulated phenotype and function ... This was confirmed in vivo in which Pik3cd GOF CD4+ T cells also acquired an aberrant TFH ... into dysfunctional antibody responses in patients with PIK3CD GOF mutations. Gain-of-function (GOF) mutations in PIK3CD ...
Tópico(s): T-cell and B-cell Immunology
2019 - Elsevier BV | Journal of Allergy and Clinical Immunology
Michael Bitar, Andreas Boldt, Stefanie Binder, Michael Borte, Karim Kentouche, Stephan Borte, Ulrich Sack,
... PubMed Google Scholar Loss- or gain-of-function (GOF) gene mutations in STAT1 and STAT3 were described ... 1514Crossref PubMed Scopus (146) Google Scholar In contrast, GOF STAT1 mutations may cause chronic mucocutaneous candidiasis (CMC). ... patient with CMC), who was diagnosed with a GOF-STAT1 mutation, exhibited a strong increase in MFI ... pSTAT1 overexpression, in contrast to patient 2 with GOF-STAT1 mutation. The MFI of pSTAT1 remained at ... phosphorylation and its inhibition in a patient with GOF-STAT1 mutation compared with healthy control. PBMCs were ...
Tópico(s): Tuberculosis Research and Epidemiology
2017 - Elsevier BV | Journal of Allergy and Clinical Immunology
Joshua Hack, Kyle J. Horning, Denise M. Juroske Short, John M. Schreiber, Joseph C. Watkins, Michael F. Hammer,
... to determine whether patients carry gain-of-function (GOF) or loss-of-function (LOF) variants to guide ... exhaustive search for individuals deemed to carry SCN8A GOF and LOF variants by means of in vitro ... truth set of 45 LOF variants and 45 GOF variants randomly selected from a set of variants ... Phenotypic categories assigned to individuals correlated strongly with GOF or LOF variants. All patients with GOF variants experienced early-onset seizures (mean age at ... including 5 key clinical features classified individuals with GOF and LOF variants into 2 distinct cohorts differing ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2023 - Wolters Kluwer | Neurology Genetics
Produção Nacional
Revisado por pares
Marco Fischer, Peter Olbrich, Jérôme Hadjadj, V. Aumann, Shahrzad Bakhtiar, Vincent Barlogis, Philipp von Bismarck, Markéta Bloomfield, Claire Booth, Emmeline P. Buddingh, Deniz Çağdaş, Martin Castelle, Alice Chan, Shanmuganathan Chandrakasan, Kritika Chetty, P. Cougoul, Étienne Crickx, Jasmeen Dara, Àngela Deyà‐Martínez, Susan Farmand, Renata Formánková, Andrew R. Gennery, Luis Ignacio González‐Granado, David Hagin, Leif G. Hanitsch, Jana Hanzlı́ková, Fabian Hauck, J. Ivorra Cortés, Kai Kisand, Ayça Kıykım, Julia Körholz, Timothy Ronan Leahy, Joris van Montfrans, Zohreh Nademi, Brigitte Nelken, Suhag Parikh, Silvi Plado, Jan Ramakers, Antje Redlich, Frédéric Rieux‐Laucat, Jacques G. Rivière, Yulia Rodina, Pérsio Roxo Júnior, Sarah Salou, Catharina Schuetz, Anna Shcherbina, Mary Slatter, Fabien Touzot, Ekrem Ünal, Arjan C. Lankester, Siobhan O. Burns, Mikko Seppänen, Olaf Neth, Michael H. Albert, Stephan Ehl, Bénédicte Neven, Carsten Speckmann,
... children) were evaluated (45 STAT1 gain of function [GOF], 21 STAT3-GOF, 1 STAT5B-GOF, 1 suppressor of cytokine signaling 1 [aka SOCS1 ] loss of function, 1 JAK1-GOF). Ruxolitinib was the predominantly prescribed JAKi (80%). Overall, ... remission) of clinical symptoms in 87% of STAT1-GOF and in 90% of STAT3-GOF patients. We documented highly heterogeneous dosing and monitoring ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2023 - Elsevier BV | Journal of Allergy and Clinical Immunology
Xuetian Yue, Cen Zhang, Yuhan Zhao, Juan Liu, Alan W. Lin, Victor M. Tan, Justin M. Drake, Lianxin Liu, Michael N. Boateng, Jun Li, Zhaohui Feng, Wenwei Hu,
... often promotes tumor progression through gain-of-function (GOF) mechanisms. However, the mechanisms underlying mutant p53 GOF are not well understood. In this study, we ... Rac1 as a critical mechanism for mutant p53 GOF to promote tumor progression. Mechanistically, mutant p53 interacts ... specific Rac1 inhibitor NSC23766 greatly inhibits mutant p53 GOF in promoting tumor growth and metastasis. Furthermore, mutant ... an unidentified and critical mechanism for mutant p53 GOF in tumorigenesis, which could be targeted for therapy ...
Tópico(s): Cell death mechanisms and regulation
2017 - Cold Spring Harbor Laboratory Press | Genes & Development
Michael J. Davis, Hae Jin Kim, Scott D. Zawieja, Jorge A. Castorena‐Gonzalez, Peichun Gui, Min Li, Brian T. Saunders, Bernd H. Zinselmeyer, Gwendalyn J. Randolph, Marı́a S. Remedi, Colin G. Nichols,
... expression of Kir6.1 gain‐of‐function mutant (GoF) subunits results in profound lymphatic contractile dysfunction and ... contrast, lymphatic endothelial‐specific expression of Kir6.1 GoF has essentially no effect on lymphatic contractile function. ... high sensitivity of LSM to K ATP channel GoF offers an explanation for the lymphoedema observed in ... expression of a Kir6.1 gain‐of‐function (GoF) subunit resulted in severely impaired lymphatic contractions and ... contrast, lymphatic endothelium‐specific expression of Kir6.1 GoF subunits had negligible effects on lymphatic contraction frequency ...
Tópico(s): Planarian Biology and Electrostimulation
2020 - Wiley | The Journal of Physiology
Jui-Yen Huang, Bruna Baumgarten Krebs, Marisha Lynn Miskus, May Lin Russell, Eamonn P. Duffy, Jason Michael Graf, Hui‐Chen Lu,
... neurons, we generated a FGFR gain-of-function (GOF) transgenic mouse, which expresses constitutively activated FGFR3 (FGFR3 K650E ) in postmitotic glutamatergic neurons. We found that GOF disrupts mitosis of radial-glia neural progenitors (RGCs), ... CUX1-positive neurons are widely dispersed throughout the GOF cortex. Such a cortical migration deficit is likely ... projecting from RGCs. RNA-sequencing analysis of the GOF embryonic cortex reveals significant alterations in several pathways ... axonal pathfinding. Collectively, our data suggest that FGFR3 GOF in postmitotic neurons not only alters axonal growth ...
Tópico(s): Microtubule and mitosis dynamics
2020 - Nature Portfolio | Scientific Reports
... 2015, Gynécologie Obstétrique Fertilité & Sénologie , 10.1016/j.gofs.2020.11.012, 49:1, (67-72), Online ... 2015, Gynécologie Obstétrique Fertilité & Sénologie , 10.1016/j.gofs.2020.11.013, 49:1, (73-78), Online ...
Tópico(s): Diversity and Career in Medicine
2020 - Lippincott Williams & Wilkins | Stroke
Michael P. Kim, Guillermina Lozano,
... the extent and array of gain-of-function (GOF) activities. Given such variables, how can knowledge regarding ... be harnessed to blunt or ablate mutant p53 GOF for therapy? In this article, we review known ... the activation of genes that contribute to p53 GOF with particular emphasis on context dependency and an evolving appreciation of GOF mechanisms.
Tópico(s): Epigenetics and DNA Methylation
2017 - Springer Nature | Cell Death and Differentiation
Oleg Timofeev, Boris Klimovich, Jean Schneikert, Michael Wanzel, Evangelos Pavlakis, Julia Han Noll, Samet Mutlu, Sabrina Elmshäuser, Andrea Nist, Marco Mernberger, Boris Lamp, Ulrich Wenig, Alexander Brobeil, Stefan Gattenlöhner, Kernt Köhler, Thorsten Stiewe,
... new tumor-promoting oncogenic properties (gain of function, GOF) (Stiewe & Haran, 2018). p53 missense mutants are broadly ...
Tópico(s): Cell death mechanisms and regulation
2019 - Springer Nature | The EMBO Journal
Hsi-en Ho, Sheryl Mathew, Michael J. Peluso, Charlotte Cunningham‐Rundles,
... standard nasal cannula)HCQ, azithromycin, convalescent plasmaRecovered538MCVID (STAT3 GOF)GLD, AIHA, ITP, lymphadenopathyNoneCough, subjective fever, fatigue, headacheFever6NANoneNot ... B subunit 1; OSA, obstructive sleep apnea; STAT3 GOF, signal transducer and activator of transcription 3 gain- ... B subunit 1; OSA, obstructive sleep apnea; STAT3 GOF, signal transducer and activator of transcription 3 gain- ...
Tópico(s): COVID-19 Clinical Research Studies
2020 - Elsevier BV | The Journal of Allergy and Clinical Immunology In Practice
Mehul Sharma, Daniel Leung, Mana Momenilandi, Lauren C.W. Jones, Lucia Pacillo, Alyssa James, Jill R. Murrell, Selket Delafontaine, Jesmeen Maimaris, Maryam Vaseghi‐Shanjani, Kate L. Del Bel, Henry Y. Lu, Gilbert T. Chua, Silvia Di Cesare, Oriol Fornés, Zhongyi Liu, Gigliola Di Matteo, Maggie P. Fu, Donato Amodio, Issan Yee San Tam, Gavin S.W. Chan, Ashish Sharma, Joshua Dalmann, Robin van der Lee, Géraldine Blanchard-Rohner, Susan Lin, Quentin Philippot, Phillip A. Richmond, Jessica J. Lee, Allison Matthews, Michael Seear, Alexandra K. Turvey, Rachael L. Philips, Terri F. Brown‐Whitehorn, Christopher Gray, Kosuke Izumi, James R. Treat, Kathleen H. Wood, Justin Lack, Asya Khleborodova, Julie E. Niemela, Xingtian Yang, Rui Liang, Lin Kui, C. S. M. Wong, Grace Wing-kit Poon, Alexander Hoischen, Caspar I. van der Made, Jing Yang, Koon Wing Chan, Jaime S. Rosa Duque, Pamela Lee, M. Ho, Brian Hon‐Yin Chung, Huong Thi Minh Le, Wanling Yang, Pejman Rohani, Ali Fouladvand, Hassan Rokni‐Zadeh, Majid Changi‐Ashtiani, Mohammad Miryounesi, Anne Puel, Mohammad Shahrooei, Andrea Finocchi, Paolo Rossi, Beatrice Rivalta, Cristina Cifaldi, Antonio Novelli, Chiara Passarelli, Stefania Arasi, Dominique Bullens, Kate Sauer, Tania Claeys, Catherine M. Biggs, Emma Morris, Sergio D. Rosenzweig, John J. O’Shea, Wyeth W. Wasserman, H. Melanie Bedford, Clara D.M. van Karnebeek, Paolo Palma, Siobhan O. Burns, Isabelle Meyts, Jean‐Laurent Casanova, Jonathan J. Lyons, Nima Parvaneh, Anh Thi Van Nguyen, Caterina Cancrini, Jennifer Heimall, Hanan Ahmed, Margaret L. McKinnon, YL Lau, Vivien Béziat, Stuart E. Turvey,
... and functional studies established their gain-of-function (GOF) phenotype with sustained STAT6 phosphorylation, increased STAT6 target ... manifestations and immunological biomarkers. This study identifies heterozygous GOF variants in STAT6 as a novel autosomal dominant ... our discovery of multiple kindreds with germline STAT6 GOF variants will facilitate the recognition of more affected ...
Tópico(s): IL-33, ST2, and ILC Pathways
2023 - Rockefeller University Press | The Journal of Experimental Medicine
Maria Elena Maccari, Martin Wolkewitz, Charlotte Schwab, Tiziana Lorenzini, Jennifer W. Leiding, Nathalie Aladjdi, Hassan Abolhassani, Wadih Abou‐Chahla, Alessandro Aiuti, Saba Azarnoush, Safa Barış, Vincent Barlogis, Federica Barzaghi, Ulrich Baumann, Markéta Bloomfield, Nadezda Bohynikova, Damien Bodet, David Boutboul, Giorgia Bucciol, Matthew Buckland, Siobhan O. Burns, Caterina Cancrini, P. Cathébras, Marina Cavazzana, Morgane Cheminant, Matteo Chinello, Peter Čižnár, Tanya Coulter, Maud D’Aveni, Olov Ekwall, Želimir Erić, Efrem Eren, Anders Fasth, Pierre Frange, Benjamin Fournier, Marina Garcia‐Prat, Martine Gardembas, Christoph B. Geier, Sujal Ghosh, Vera Goda, Lennart Hammarström, Fabian Hauck, Maximilian Heeg, Edyta Heropolitańska–Pliszka, Anna Hilfanova, Stephen Jolles, Elif Karakoç-Aydıner, Gerhard Kindle, Ayça Kıykım, Christian Klemann, Patra Koletsi, Sylwia Kołtan, Irina Kondratenko, Julia Körholz, Renate Krüger, Éric Jeziorski, Romain Lévy, G. Le Guenno, Guillaume Lefèvre, Vassilios Lougaris, Antonio Marzollo, Nizar Mahlaoui, Marion Malphettes, Andrea Meinhardt, Étienne Merlin, Isabelle Meyts, Tomáš Milota, Fernando Moreira, Despina Moshous, Anna Mukhinа, Olaf Neth, Jennifer Neubert, Bénédicte Neven, Alexandra Nieters, R. Nové-Josserand, Éric Oksenhendler, Ahmet Özen, Peter Olbrich, Antoinette Perlat, Małgorzata Pac, Jana Pachlopnik Schmid, Lucia Pacillo, Alba Parra-Martínez, Olga Paschenko, Isabelle Pellier, Asena Pınar Sefer, Alessandro Plebani, Dominique Plantaz, Seraina Prader, L. Raffray, Henrike Ritterbusch, Jacques G. Rivière, Beatrice Rivalta, Stephan Rusch, Inga Sakovich, Sinisa Savic, Raphael Scheible, N. Schleinitz, Catharina Schuetz, Ansgar Schulz, Anna Šedivá, Michaëla Semeraro, Svetlana O. Sharapova, Anna Shcherbina, Mary Slatter, Georgios Sogkas, Pere Soler‐Palacín, Carsten Speckmann, Jean-Louis Stéphan, Felipe Suárez, Alberto Tommasini, Johannes Trück, Annette Uhlmann, Koen van Aerde, Joris van Montfrans, Horst von Bernuth, Klaus Warnatz, Tony Williams, Austen Worth, Winnie Ip, Capucine Pïcard, Émilie Catherinot, Zohreh Nademi, Bodo Grimbacher, Lisa Forbes Satter, Sven Kracker, Anita Chandra, Alison M. Condliffe, Stephan Ehl, Markus G. Seidel, Mikko Seppänen, Andrew R. Gennery, Maria Kanariou, Sofia Tantou, Sofia Grigoriadou, Gabriella Cericola, Leif G. Hanitsch, Carmen Scheibenbogen, Eva Hlaváčková, Gergely Kriván, Frances K. McGuire, Timothy Ronan Leahy, David Edgar, Shahrzad Bakhtiar, Peter Bader, Géraldine Blanchard-Rohner, Filomeen Haerynck, Karlien Claes, Kai Lehmberg, Ingo Müller, Susan Farmand, Maria Faßhauer, Dagmar Graf, João Farela Neves, Larysa Kostyuchenko, Luis Ignacio González‐Granado, Miloš Jeseňák, Maria Carrabba, Fabio Gavarini, Claudio Pignata, Giuliana Giardino, Ilknur Kökçü Karadağ, Alişan Yıldıran, Gonca Hancıoğlu, Pavlína Králíčková, Sandra Steinmann, Barbara Pietrucha, Michael Gernert, Maarja Soomann, Torsten Witte, Adam Markocsy, Beata Wolska‐Kuśnierz, Philippe Randrianomenjanahary, Jérémie Rouger, Stavroula Kostaridou, Dariia V. Osypchuk, Yulia Rodina, О. А. Швец,
... deficiency, NFKB1 deficiency, and STAT3 gain-of-function (GOF) disease; and identify predictors of severity in APDS. ... disease and enteropathy are more common in STAT3 GOF and CTLA4 deficiency. Endocrinopathies are most frequent in STAT3 GOF, but growth impairment is also common, particularly in ...
Tópico(s): Platelet Disorders and Treatments
2023 - Elsevier BV | Journal of Allergy and Clinical Immunology
Richard A Allard, E. Joseph Metzger, Neil P Barton, Li Li, N. T. Kurtz, Michael W Phelps, D. S. Franklin, Ole Martin Smedstad, Julia Crout, Pamela G. Posey,
... the operational US Navy Global Ocean Forecasting System (GOFS) 3.1 but do not assimilate ice thickness ... set of forecasts are initialized from the same GOFS 3.1 fields but with sea ice thickness ... September 2018 minimum sea ice extent initialized with GOFS 3.1 ice thickness was over-predicted by ...
Tópico(s): Climate variability and models
2020 - Cambridge University Press | Annals of Glaciology
Amy N. Shore, Sophie Colombo, William F. Tobin, Sabrina Petri, Erin R. Cullen, Soledad Domínguez, Christopher D. Bostick, Michael Beaumont, Damian J. Williams, Dion Khodagholy, Mu Yang, Cathleen Lutz, Yueqing Peng, Jennifer N. Gelinas, David B. Goldstein, Michael J. Boland, Wayne N. Frankel, Matthew C. Weston,
Gain-of-function (GOF) variants in K+ channels cause severe childhood epilepsies, but there are no mechanisms to explain how increased K+ currents ... in mediating the epileptogenic effects of KCNT1 channel GOF, offering cell-type-specific currents and effects as ...
Tópico(s): Neural dynamics and brain function
2020 - Cell Press | Cell Reports
Michael J. Davis, Jorge A. Castorena‐Gonzalez, Hae Jin Kim, Min Li, Marı́a S. Remedi, Colin G. Nichols,
... autosomal dominant disorder caused by gain-of-function (GoF) mutations in the Kir6.1 and SUR2 subunits ... However, further investigation of vessels from all three GoF mouse strains revealed significant disruption in contraction wave ... occur in proportion to the degree of molecular GoF in Kir6.1 or SUR2. This is the ...
Tópico(s): Cardiovascular and Diving-Related Complications
2023 - Oxford University Press | Function
Adam Duarte, Michael J. Adams, James T. Peterson,
... evaluated if the parametric bootstrap goodness-of-fit (GOF) test can be used to indicate bias in ... of unmodeled heterogeneity was substantial. The parametric bootstrap GOF test did not perform well as a diagnostic ...
Tópico(s): Genetic and phenotypic traits in livestock
2018 - Elsevier BV | Ecological Modelling
Xiangbing Meng, Jason Z. Gao, Sean Michael T. Gomendoza, John Wing Li, Shujie Yang,
... mutated p53 (Mutp53) proteins acquire gain-of-function (GOF) activities as oncogenes to promote cancer progression, which ... aberrant expression of p53. In cancer cells with GOF Mutp53, statins can induce CHIP-mediated degradation of ...
Tópico(s): Cancer, Lipids, and Metabolism
2021 - Frontiers Media | Frontiers in Medicine
Zeinab Hosseini, Michael Marinello, Christa Decker, Brian E. Sansbury, Sudeshna Sadhu, Brennan D. Gerlach, Ramon Bossardi Ramos, Alejandro P. Adam, Matthew Spite, Gabrielle Fredman,
... with a gain-of-function mutant PCSK9 (AAV8-gof-PCSK9) and fed a Western diet for 16 ... fibrous caps and improved efferocytosis compared with AAV8-gof-PCSK9 injected wt controls. Additionally, hypercholesterolemic Mlkl-/- mice ...
Tópico(s): Fatty Acid Research and Health
2021 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Mathew Savage, Yongqiang Cheng, Timothy L. Easun, Jennifer E. Eyley, Stephen P. Argent, Mark R. Warren, William Lewis, Claire A. Murray, Chiu C. Tang, Mark D. Frogley, Gianfelice Cinque, Junliang Sun, Svemir Rudić, Richard T. Murden, Michael J. Benham, Andrew N. Fitch, Alexander J. Blake, Anibal J. Ramirez‐Cuesta, Sihai Yang⧫, Martin Schröder,
... Final R1 (wR2) = 0.0255 (0.0266) with GoF = 1.173. The final difference Fourier extrema were ... Final R1 (wR2) = 0.0277 (0.0283) with GoF = 1.223. The final difference Fourier extrema were ...
Tópico(s): Industrial Gas Emission Control
2016 - | Advanced Materials