Giles Smith, Andrew Robson, William F. V. Long, Amanda Andrews, Phil Yates, Andrew Billen, Steve Bird and David Rose, Robert Cole, Victor Adebowale, Jonathan Lloyd-Jones, Daniel McGrory and Greg Hurst, DJM, Neelam Verjee, David Aaronovitch, Chris Butler-Stroud Chief Executive, Peter Lansley, Paul Hoggart, Major (Ret'd) David Hepburn, Philip Howard, Cynthia Hall, David Chater, James Ducker, Sir Nigel Crisp Chief Executive, Bronwen Maddox Foreign Editor, Richard Beeston and Stephen Farrell and Michael Evans, Elizabeth Judge, Sam Marlowe, Roger Maynard, D. S. A. Murray, Stephanie Hilborne Chief Executive, Geoff Brown, Nicola Woolcock and Ben Hoyle, Joe Joseph, Jack Carter, John Arlidge, Pat Gibson, C. J. Brougham, Stewart Tendler Crime Correspondent, Tom Bawden, Steve Bird, Dan Sabbagh Media Editor, James Doran Wall Street Correspondent, Shirley English, Gary Jacob, Dean Godson, Angela Jameson Industrial Correspondent, Stephen Lawson, Dan Sabbagh, Libby Purves, Nicholas Blanford, Stephen Farrell, James Delingpole, Charles Bremner, Jonathan Richards, Michael Glover, John Fletcher, Mark Pougatch, Matt Dickinson Chief Football Correspondent, Richard Susskind, Hugo Rifkind, Caroline Merrell Banking Correspondent, Angela Jameson, Daniel McGrory, Edward Fennell, Oliver Kay, Gerard Baker, Major (Ret'd) Michael Hamilton, Sarah Vine, Rick Broadbent, Morgan Falconer, Mark Henderson Science Correspondent, Ann Treneman, Carl Mortished and Adam Sage, Ronald Forrest, Simon de Bruxelles, Rob Wright, Hannah Hennessy, Raymond Keene, Richard Hobson One-day Cricket Correspondent, Daniel Allen, Ian Evans, Matt Dickinson, Philip Webster and Anthony Browne, Tom Benyon, Dr Tanya Byron, Kaveh Solhekol, Rosemary Bennett Deputy Political Editor, Robert Winston, Peta Bee, Tim Worstall, Jeremy Page, Chris Campling, Patrick Hosking, Colin Bobb-Semple, Erica Wagner, David Mattin, Peter Dixon, Nick Hasell, David Hands Rugby Correspondent, Paul Simons, Tim Hands, Anna Frame, Steve Bird and Valerie Elliott, Andrew Sturcke, James Doran, Dominic Maxwell, Ashling O'connor, Graham Searjeant Financial Editor, George Caulkin, Russell Jenkins, Alan Lee, Peter Riddell, David Diprose, Graham Wynne Chief Executive, Peter Jenson, Jack Malvern Arts Reporter, Bruce worth, Mark Henderson, Martin Waller, Chris Ayres, Patrick Foster, Carl Mortished International Business Editor, Nigel Hawkes Health Editor, Riaz Farooqi, Richard Ford and Adam Fresco, Stephen Dalton, Leo Lewis, Richard Morrison, Frances Gibb, Sam Fanshawe, Director, Michael Moore, Olav Bjortomt, Jill Bowling Director, Liz Leffman, Sam Lister Health Correspondent, Alexia Wellbelove Director, Lisa Verrico, Caroline Holliday,
... Caesar Salad with Ortiz Anchovies Caesar salad with Ortiz anchovies My ... supports no ideology, says Michael Glover How to be cool-join the fan ...
2005 - Gale Group | TDA
Enery Lorenzo, Katia I. Camacho‐Cáceres, Alexander J. Ropelewski, Juan Fernando Rosas, Michael Ortiz-Mojer, Lynn M. Pérez‐Marty, Juan Irizarry, Valerie Gonzalez, Jesús Andrés Rodríguez Sarasty, Mauricio Cabrera‐Ríos, Clara E. Isaza,
Establishing how a series of potentially important genes might relate to each other is relevant to understand the origin and evolution of illnesses, such as cancer. High-throughput biological experiments have played a critical role in providing information in this regard. A special challenge, however, is that of trying to conciliate information from separate microarray experiments to build a potential genetic signaling path. This work proposes a two-step analysis pipeline, based on optimization, ...
Tópico(s): Cell Image Analysis Techniques
2015 - Multidisciplinary Digital Publishing Institute | Microarrays
Katia I. Camacho‐Cáceres, Juan C. Acevedo‐Díaz, Lynn M. Pérez‐Marty, Michael Ortiz, Juan Irizarry, Mauricio Cabrera‐Ríos, Clara E. Isaza,
Microarrays can provide large amounts of data for genetic relative expression in illnesses of interest such as cancer in short time. These data, however, are stored and often times abandoned when new experimental technologies arrive. This work reexamines lung cancer microarray data with a novel multiple criteria optimization-based strategy aiming to detect highly differentially expressed genes. This strategy does not require any adjustment of parameters by the user and is capable to handle multiple ...
Tópico(s): Machine Learning in Bioinformatics
2015 - Wiley | Cancer Medicine
Joram Huckriede, Sara Bülow Anderberg, Albert Morales, Femke de Vries, Michael Hultström, Anders Bergqvist, Jose T. Ortiz‐Pérez, Jan Willem Sels, Kanin Wichapong, Miklós Lipcsey, Marcel C.G. van de Poll, Anders Larsson, Tomas Luther, Chris Reutelingsperger, Pablo Garcı́a de Frutos, Robert Frithiof, Gerry A. F. Nicolaes,
Coronavirus disease 19 (COVID-19) presents with disease severities of varying degree. In its most severe form, infection may lead to respiratory failure and multi-organ dysfunction. Here we study the levels and evolution of the damage associated molecular patterns (DAMPS) cell free DNA (cfDNA), extracellular histone H3 (H3) and neutrophil elastase (NE), and the immune modulators GAS6 and AXL in relation to clinical parameters, ICU scoring systems and mortality in patients (n = 100) with severe COVID-19. ...
Tópico(s): Phagocytosis and Immune Regulation
2021 - Nature Portfolio | Scientific Reports
Mercè Madre, Erick J. Canales‐Rodríguez, Jordi Ortiz‐Gil, Andréa Murru, C. Torrent, Elvira Bramon, Víctor Pérez, Michael Orth, Paolo Brambilla, Eduard Vieta, Benedikt L. Amann,
Objectives The neurobiological basis and nosological status of schizoaffective disorder remains elusive and controversial. This study provides a systematic review of neurocognitive and neuroimaging findings in the disorder. Methods A comprehensive literature search was conducted via PubMed, ScienceDirect, Scopus and Web of Knowledge (from 1949 to 31st March 2015) using the keyword ‘schizoaffective disorder’ and any of the following terms: ‘neuropsychology’, ‘cognition’, ‘structural neuroimaging’, ‘functional ...
Tópico(s): Electroconvulsive Therapy Studies
2016 - Wiley | Acta Psychiatrica Scandinavica
Clara E. Isaza, Juan Fernando Rosas, Enery Lorenzo, Arlette Marrero, Cristina Ortiz, Michael Ortiz, Lynn Perez, Mauricio Cabrera‐Ríos,
Abstract Establishing the role that different genes play in the development of cancer is a daunting task. A step toward this end is the detection of genes that are important in the illness from high‐throughput biological experiments. Furthermore, it is safe to say that it is highly unlikely that these show expression changes independently, even with a list of potentially important genes. A biological signaling pathway is a more plausible underlying mechanism as favored in the literature. This work ...
Tópico(s): Computational Drug Discovery Methods
2018 - Wiley | Cancer Medicine
Vı́ctor M. Pérez-Garcı́a, Gabriel F. Calvo, Jesús J. Bosque, Odelaisy León-Triana, Juan Jiménez-Sánchez, Julián Pérez-Beteta, Juan Belmonte-Beitia, Manuel Valiente, Lucía Zhu, Pedro García‐Gómez, Pilar Sánchez‐Gómez, Esther Hernández‐SanMiguel, Rafael Hortigüela, Youness Azimzade, David Molina-García, Alvaro A. Martinez, Ángel Acosta Rojas, Ana Ortiz de Méndivil, François M. Vallette, Philippe Schucht, Michael Murek, M. Perez-Cano, David Albillo, Antonio Francisco Honguero Martínez, G.A. Jiménez Londoño, Estanislao Arana, Ana María García Vicente,
Most physical and other natural systems are complex entities that are composed of a large number of interacting individual elements. It is a surprising fact that they often obey the so-called scaling laws that relate an observable quantity to a measure of the size of the system. Here, we describe the discovery of universal superlinear metabolic scaling laws in human cancers. This dependence underpins increasing tumour aggressiveness, owing to evolutionary dynamics, that leads to an explosive growth ...
Tópico(s): Evolution and Genetic Dynamics
2020 - Nature Portfolio | Nature Physics
Michael Rudnicki, Justyna Siwy, Ralph Wendt, Mark Lipphardt, Michael Koziolek, Dita Maixnerová, Björn Peters, Julia Kerschbaum, Johannes Leierer, Michaela Neprašová, Mirosław Banasik, Ana B. Sanz, María Vanessa Pérez-Gómez, Alberto Ortíz, Bernd Stegmayr, Vladimı́r Tesař, Harald Mischak, Joachim Beige, Heather N. Reich, Joachim Beige, Ralph Wendt, Justyna Siwy, Petra Zürbig, Harald Mischak, Annika Durban, Julia Raad, Igor Golovko, Heather N. Reich, Ping Lam, Stuart Yang, Jiménez Díaz, Ana B. Sanz, Beatriz Fernández‐Fernández, Jorge Rojas-Rivera, María Vanessa Pérez-Gómez, Alberto Ortíz, María Dolores Sánchez-Niño, Jinny Sánchez-Rodríguez, Michael Rudnicki, Julia Kerschbaum, Johannes Leierer, Gert Mayer, Bernd Stegmayr, Björn Peters,
Abstract Background Risk of kidney function decline in immunoglobulin A (IgA) nephropathy (IgAN) is significant and may not be predicted by available clinical and histological tools. To serve this unmet need, we aimed at developing a urinary biomarker-based algorithm that predicts rapid disease progression in IgAN, thus enabling a personalized risk stratification. Methods In this multicentre study, urine samples were collected in 209 patients with biopsy-proven IgAN. Progression was defined by tertiles ...
Tópico(s): Platelet Disorders and Treatments
2020 - Oxford University Press | Nephrology Dialysis Transplantation
Mauricio Gómez‐Suárez, Itzel Zenidel Gutiérrez-Martínez, José Antonio Hernández-Trejo, Marcela Hernández-Ruíz, Dimelza Suárez-Pérez, Aurora Candelario, Ryuta Kamekura, Óscar Medina‐Contreras, Michael Schnoor, Vianney Ortiz‐Navarrete, Nicolás Villegas‐Sepúlveda, Charles A. Parkos, Asma Nusrat, Porfirio Nava,
Akt activation has been associated with proliferation, differentiation, survival and death of epithelial cells. Phosphorylation of Thr308 of Akt by phosphoinositide-dependent kinase 1 (PDK1) is critical for optimal stimulation of its kinase activity. However, the mechanism(s) regulating this process remain elusive. Here, we report that 14-3-3 proteins control Akt Thr308 phosphorylation during intestinal inflammation. Mechanistically, we found that IFNγ and TNFα treatment induce degradation of the ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2016 - Springer Nature | Cell Death and Differentiation
Héctor Díaz-Zabala, Ana P. Ortíz, L. Henry Garland, Kristine Jones, Cynthia M. Pérez, Edna Mora, Nelly Arroyo, Tarás K. Oleksyk, Miguel Echenique, Jaime Matta, Michael Dean, Julie Dutil,
Breast cancer is the most common cause of cancer diagnosis in women and is responsible for considerable mortality among the women of Puerto Rico. However, there are few studies in Puerto Rico on the genetic factors influencing risk. To determine the contribution of pathogenic mutations in BRCA1 and BRCA2, we sequenced these genes in 302 cases from two separate medical centers, who were not selected for age of onset or family history. We identified nine cases that are carriers of pathogenic germline ...
Tópico(s): Nutrition, Genetics, and Disease
2018 - Multidisciplinary Digital Publishing Institute | Cancers
Stephen A. Harrison, Vincent Wai–Sun Wong, Takeshi Okanoue, Natalie Bzowej, Raj Vuppalanchi, Ziad Younes, Anita Kohli, Shiv Kumar Sarin, Stephen H. Caldwell, Naim Alkhouri, Mitchell L. Shiffman, Marianne Camargo, Georgia Li, Kathryn Kersey, Catherine Jia, Yanni Zhu, C. Stephen Djedjos, G. Mani Subramanian, Robert P. Myers, Nadege Gunn, Aasim Sheikh, Quentin M. Anstee, Manuel Romero‐Gómez, Michael Trauner, Zachary Goodman, Eric Lawitz, Zobair M. Younossi, Adrián Gadano, Marcelo Martins, Peter Angus, John Bate, Mark Danta, Jacob George, Alexander Hodge, Nickolas Kontorinis, S.A. Roberts, Santosh Sanagapalli, Richard Skoien, Alexander Thompson, Amany Zekry, Rudolf Stauber, Michael Trauner, Christophe Moreno, Hendrik Reynaert, Len Verbeke, Mário Reis Álvares‐da‐Silva, Edison Roberto Parise, Cláudia P. Oliveira, Roberta Chaves Araújo, Ana de Lourdes Candolo Martinelli, Meredith A. Borman, Natasha Chandok, Magdy Elkhashab, Hughie Fraser, Kelly Kaita, Mang Ma, Paul Marotta, Alnoor Ramji, Edward Tam, Eric M. Yoshida, Mark G. Swain, Giada Sebastiani, Denis Petrunia, Armand Abergel, Rodolphe Anty, Marc Bourlière, Jérôme Boursier, Christophe Bureau, Laurent Castéra, François Habersetzer, Christophe Hézode, V. de Lédinghen, Vincent Leroy, V. Loustaud‐Ratti, Philippe Mathurin, Stanislas Pol, Fabien Zoulim, Holger Hinrichsen, Patrick Ingiliz, Frank Lammert, Michael Manns, Jörn M. Schattenberg, Ingolf Schiefke, Christian Trautwein, Stefan Zeuzem, Aric J. Hui, K Li, Vincent Wai–Sun Wong, Subrat Kumar Acharya, Abhijit Chowdhury, Ajay Duseja, Dharmesh Kapoor, Shrikant Mukewar, Shiv Kumar Sarin, Samir Shah, S. Shalimar, Ajit Sood, BV Tantry, Ziv Ben‐Ari, Helena Katchman, Rifaat Safadi, Ella Veitsman, Eli Zuckerman, Maurizia Brunetto, Pietro Lampertico, Alessandra Mangia, Takemi Akahane, Norio Akuta, Norio Akuta, Yuichiro Eguchi, Shigetoshi Fujiyama, Takuya Genda, Yoichi Hiasa, Akio Ido, Fusao Ikeda, Tadashi Ikegami, Kento Imajo, Yoshito Itoh, Motoh Iwasa, Yoshiyasu Karino, Naoya Kato, Takumi Kawaguchi, Miwa Kawanaka, Masahiro Kido, Tomoo Kobayashi, Masayuki Kurosaki, Yasushi Matsuzaki, Eiji Mita, Eishiro Mizukoshi, Takashi Nakahara, Hideyuki Nomura, Kazuo Notsumata, Takeshi Okanoue, Satoshi Saito, Hiroshi Sakugawa, Yoshiyuki Suzuki, Koichi Takaguchi, Akinobu Takaki, Tomoyuki Takashima, Saiyu Tanaka, Keiji Tsuji, Yoshiyuki Ueno, Takeji Umemura, Hirofumi Uto, Nobuyuki Yamashita, Mikio Yanase, Hiroshi Yatsuhashi, Masashi Yoneda, Wah‐Kheong Chan, Soek Siam Tan, Laura Garza, Alma Ladron de Guevara Cetina, Ronald M. Angeles, Francisca Martinez Silva, Karel van Erpecum, David Orr, Maciej Jabłkowski, Jerzy Jaroszewicz, José Manuel Ramos, Taufique Ahmed, Tiing Leong Ang, Yock Young Dan, Boon Bee George Goh, Kalaiyarasi Kaliyaperumal, Christopher Yip, Soon Koo Baik, Byoung Kuk Jang, Dae Won Jun, Won‐Ho Kim, Hyung Joon Kim, Ji Hoon Kim, Kwan Sik Lee, Chun Kyon Lee, Young-Suk Lim, Jun Yong Park, Won Young Tak, Salvador Augustín, Sebastián Pérez, Juan Caballería, José Luís, C Panero, José A. Rodríguez, Javier Crespo, Javier García‐Samaniego, Pere Ginés Gibert, M. Prieto, Manuel Romero‐Gómez, Juan Turnés, Jean‐François Dufour, Alberto Moriggia, I-Shyan Sheen, Jia‐Horng Kao, Pin‐Nan Cheng, Jee‐Fu Huang, Sheng‐Shun Yang, Wei‐Wen Su, Chi-Yi Chen, Rong‐Nan Chien, Gin‐Ho Lo, Chi-Jen Chu, Horng-Yuan Wang, Jui-Ting Hu, Yi‐Wen Huang, Kosh Agarwal, Michael Allison, Quentin M. Anstee, Andrew D. Austin, Andrew Fowell, Chin Lye Ch’ng, Pinelopi Manousou, Philip N. Newsome, Stephen Ryder, Arun Shankar, Manal F. Abdelmalek, Gary A. Abrams, Humberto Aguilar, Imtiaz Alam, Laura Alba, Naim Alkhouri, Alina M. Allen, Bashar Aqel, Luis A. Balart, A. Sidney Barritt, Jaideep Behari, Michael Bennett, David I. Bernstein, Bal Raj Bhandari, Maurizio Bonacini, Brian B. Borg, Kimberly Brown, Natalie Bzowej, Stephen H. Caldwell, Tawfik N. Chami, Allan Coates, Adolfo Cueli, Mitchell Davis, Andrew S. deLemos, Archita P. Desai, Billy Dunn, Nelson Henrique da Silva Ferreira, Michael Fine, Roberto Firpi-Morell, Curtis Freedland, B. Freilich, Michael Fuchs, Michael Galambos, Juan F. Gallegos‐Orozco, Greg Galler, Maged P. Ghali, Reem Ghalib, Satinder Gill, Marcum Gillis, Richard Gilroy, S. Gordon, Nadege Gunn, Dina Halegoua‐De Marzio, Mohamed A. Hassan, Tarek Hassanein, Robert Herring, John D. Hong, Jonathan Huang, Heidi Kabler, Zeid Kayali, W Knapple, Geetha Kolli, Kris V. Kowdley, Richard A. Krause, Eric Lawitz, Steven D. Lidofsky, Joseph K. Lim, Donald Lipkis, Rohit Loomba, Amar Mahgoub, Miguel Malespin, Richard Manch, Steven Mannis, Paul Manos, Thomas J. McDonald, Mark McKenzie, Edward Mena, Raphael B. Merriman, Martin Moehlen, Richard Murdoch Montgomery, Robert L. Murphy, Yamini Natarajan, Guy Neff, Mazen Noureddin, Grisell Ortiz‐Lasanta, Mangesh Pagadala, Keyur Patel, Heather Patton, Adam Peyton, Neville R. Pimstone, John Poulos, David Pound, Nikolaos Pyrsopoulos,
•Selonsertib was safe and inhibited its target (ASK1) but did not lead to fibrosis regression or reduce disease progression in NASH. •Improvement in liver fibrosis on biopsy was associated with improvement only in other histologic features. •Improvements in ELF score and liver stiffness by transient elastography correlated with a variety of clinical parameters. Background & Aims Apoptosis signal-regulating kinase 1 (ASK1) plays a key role in hepatocyte injury, inflammation, and fibrosis in non-alcoholic ...
Elsevier BV
Produção Nacional
Revisado por pares
Daniel S. Karp, Rebecca Chaplin‐Kramer, Timothy D. Meehan, Emily A. Martin, Fabrice DeClerck, Heather Grab, Claudio Gratton, Lauren Hunt, Ashley E. Larsen, Alejandra Martínez‐Salinas, Megan E. O’Rourke, Adrien Rusch, Katja Poveda, Mattias Jonsson, Jay A. Rosenheim, Nancy A. Schellhorn, Teja Tscharntke, S. D. Wratten, Wei Zhang, Aaron L. Iverson, Lynn S. Adler, Matthias Albrecht, Audrey Alignier, Gina M. Angelella, Muhammad Zubair Anjum, Jacques Avelino, Péter Batáry, J.M. Baveco, Felix J.J.A. Bianchi, Klaus Birkhofer, Eric Bohnenblust, Riccardo Bommarco, Michael J. Brewer, Berta Caballero‐López, Yves Carrière, Luísa G. Carvalheiro, Luis Cayuela, Mary Centrella, Aleksandar Ćetković, Dominic C. Henri, Ariane Chabert, Alejandro C. Costamagna, Aldo De la Mora, Joop de Kraker, Nicolas Desneux, Eva Diehl, Tim Diekötter, Carsten F. Dormann, James O. Eckberg, Martin H. Entling, Daniela Fiedler, Pierre Franck, F. J. Frank van Veen, Thomas Frank, Vesna Gagic, Michael P. D. Garratt, Awraris Getachew, David J. Gonthier, Peter B. Goodell, Ignazio Graziosi, Russell L. Groves, Geoff M. Gurr, Zachary Hajian‐Forooshani, George E. Heimpel, John D. Herrmann, Anders S. Huseth, Diego J. Inclán, Adam J. Ingrao, Iv Phirun, Katja Jacot, Gregg A. Johnson, Laura Jones, Marina Kaiser, Joe M. Kaser, Tamar Keasar, Tania N. Kim, Miriam Kishinevsky, Douglas A. Landis, Blas Lavandero, Claire Lavigne, Anne Le Ralec, Debissa Lemessa, Deborah K. Letourneau, Heidi Liere, Yanhui Lu, Yael Lubin, Tim Luttermoser, Bea Maas, Kevi Mace, Filipe Madeira, Viktoria Mader, Anne Marie Cortesero, Lorenzo Marini, Eliana Martínez Pachón, Holly M. Martinson, Philippe Menozzi, Matthew G. E. Mitchell, Tadashi Miyashita, Gonzalo A. R. Molina, Marco A. Molina‐Montenegro, Matthew E. O’Neal, Itai Opatovsky, Sebastián Ortiz-Martínez, Michael Nash, Örjan Östman, Annie Ouin, Damie Pak, Daniel Paredes, Soroush Parsa, Hazel Parry, Ricardo Pérez, David J. Perović, Julie A. Peterson, Sandrine Petit, Stacy M. Philpott, Manuel Plantegenest, Milan Plećaš, Therese Pluess, Xavier Pons, Simon G. Potts, Richard F. Pywell, David W. Ragsdale, Tatyana A. Rand, Lucie Raymond, Benoît Ricci, Chris Sargent, Jean‐Pierre Sarthou, Julia Saulais, Jessica Schäckermann, Nick P. Schmidt, Gudrun Schneider, Christof Schüepp, Frances S. Sivakoff, Henrik G. Smith, Kaitlin Stack Whitney, Sonja Stutz, Zsofia Szendrei, Mayura B. Takada, Hisatomo Taki, Giovanni Tamburini, Linda J. Thomson, Yann Tricault, Noëlline Tsafack, Matthias Tschumi, Muriel Valantin‐Morison, Mai Văn Trịnh, Wopke Van der Werf, Kerri T. Vierling, Ben P. Werling, Jennifer B. Wickens, Victoria J. Wickens, Ben A. Woodcock, Kris A. G. Wyckhuys, Haijun Xiao, Mika Yasuda, Akira Yoshioka, Yi Zou,
Significance Decades of research have fostered the now-prevalent assumption that noncrop habitat facilitates better pest suppression by providing shelter and food resources to the predators and parasitoids of crop pests. Based on our analysis of the largest pest-control database of its kind, noncrop habitat surrounding farm fields does affect multiple dimensions of pest control, but the actual responses of pests and enemies are highly variable across geographies and cropping systems. Because noncrop ...
Tópico(s): Plant Parasitism and Resistance
2018 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Jillian Friedrich, Holly Kordasiewicz, Brennon O’Callaghan, Hillary P. Handler, Carmen Wagener, Lisa Duvick, Eric E. Swayze, Orion Rainwater, Bente Hofstra, Michael A. Benneyworth, Tessa Nichols‐Meade, Praseuth Yang, Chen Zhao, Judit Perez Ortiz, H. Brent Clark, Gülin Öz, Sarah N. Larson, Huda Y. Zoghbi, Christine Henzler, Harry T. Orr,
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited ataxia caused by expansion of a translated CAG repeat encoding a glutamine tract in the ataxin-1 (ATXN1) protein. Despite advances in understanding the pathogenesis of SCA1, there are still no therapies to alter its progressive fatal course. RNA-targeting approaches have improved disease symptoms in preclinical rodent models of several neurological diseases. Here, we investigated the therapeutic capability of an antisense oligonucleotide ( ...
Tópico(s): Mitochondrial Function and Pathology
2018 - American Society for Clinical Investigation | JCI Insight
Monisha Rastogi, Christian Leidlmair, Lukas An der Lan, J. Ortiz de Zárate, Ricardo Pérez de Tudela, Massimiliano Bartolomei, Marta I. Hernández, José Campos‐Martínez, Tomás González‐Lezana, J. Hernández‐Rojas, J. Bretón, P. Scheier, Michael Gatchell,
We report on a combined experimental and theoretical study of Li$^+$ ions solvated by up to 50 He atoms. The experiments show clear enhanced abundances associated with He$_n$Li$^+$ clusters where $n=2$, 6, 8, and 14. We find that classical methods, e.g.\ Basin-Hopping (BH), give results that qualitatively agree with quantum mechanical methods such as path integral Monte Carlo, diffusion Monte Carlo and quantum free energy, regarding both energies and the solvation structures that are formed. The theory ...
Tópico(s): Cold Atom Physics and Bose-Einstein Condensates
2018 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Milton Valencia-Ortiz, Afef Marzougui, Chongyuan Zhang, Sapinder Bali, Steven Odubiyi, Vidyasagar Sathuvalli, Nilsa A. Bosque‐Pérez, Michael Pumphrey, Sindhuja Sankaran,
Pest attacks on plants can substantially change plants' volatile organic compounds (VOCs) emission profiles. Comparison of VOC emission profiles between non-infected/non-infested and infected/infested plants, as well as resistant and susceptible plant cultivars, may provide cues for a deeper understanding of plant-pest interactions and associated resistance. Furthermore, the identification of biomarkers-specific biogenic VOCs-associated with the resistance can serve as a non-destructive and rapid ...
Tópico(s): Insect and Arachnid Ecology and Behavior
2022 - Multidisciplinary Digital Publishing Institute | Sensors
Natalia Egri, Chelsea Bentow, Laura Rubió, Gary L. Norman, Susana López-Sañudo, Michael Mähler, Albert Pérez-Isidro, Ricard Cervera, Odette Viñas, Gerard Espinosa, Estíbaliz Ruiz‐Ortiz,
Antibodies to phospholipids (aPL) and associated proteins are a hallmark in the diagnosis of anti-phospholipid syndrome (APS). Those included in the classification criteria are the lupus anticoagulant (LA) and the IgG and IgM isotypes of anticardiolipin (aCL) and anti-beta-2 glycoprotein I (β2GPI) antibodies. Non-classification criteria markers such as autoantibodies that recognize the phosphatidylserine/prothrombin (aPS/PT) complex have been proposed as biomarkers for APS. Studies of aPS/PT antibodies ...
Tópico(s): Diabetes and associated disorders
2021 - Frontiers Media | Frontiers in Immunology
Judit Perez Ortiz, Nissa Mollema, Nicholas Toker, Carolyn J. Adamski, Brennon O’Callaghan, Lisa Duvick, Jillian Friedrich, Michael A. Walters, Jessica M. Strasser, Jon E. Hawkinson, Huda Y. Zoghbi, Christine Henzler, Harry T. Orr, Sarita Lagalwar,
Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje cells. In addition to polyQ expansion of ataxin-1 protein (ATXN1), phosphorylation of ATXN1 at the serine 776 residue (ATXN1-pS776) plays a significant role in protein toxicity. Utilizing a biochemical approach, pharmacological agents and cell-based assays, including SCA1 patient iPSC-derived neurons, we examine the role of Protein Kinase A ( ...
Tópico(s): DNA Repair Mechanisms
2018 - Elsevier BV | Neurobiology of Disease
Fiona Child, Pablo L. Ortiz‐Romero, Rute Alvarez, M. Bagot, Rudolf Stadler, Michael Weichenthal, Rita Valério Alves, Pietro Quaglino, M. Beylot‐Barry, Richard Cowan, Larisa J. Geskin, A. Pérez‐Ferriols, Peter Hellemans, Yusri Elsayed, Charles E. Phelps, Ann‐Sofie Forslund, Makio Kamida, Pier Luigi Zinzani,
Quisinostat is a hydroxamate, second‐generation, orally available pan‐histone deacetylase inhibitor. To evaluate the efficacy and safety of oral quisinostat in patients with previously treated cutaneous T‐cell lymphoma (CTCL). Patients received quisinostat 8 mg or 12 mg on days 1, 3 and 5 of each week in 21‐day treatment cycles. Primary efficacy end point was cutaneous response rate (RR) based on the modified Severity Weighted Assessment Tool (mSWAT). Secondary end points included global RR, duration ...
Tópico(s): T-cell and Retrovirus Studies
2016 - Oxford University Press | British Journal of Dermatology
Christian Wegele, Yannick Schreiner, Alba Perez Ortiz, Svetlana Hetjens, Christiane Otto, Michael Boettcher, Thomas Schaible, Neysan Rafat,
Since there are no data available on the influence of the time point of ECMO initiation on morbidity and mortality in patients with congenital diaphragmatic hernia (CDH), we investigated whether early initiation of ECMO after birth is associated with a beneficial outcome in severe forms of CDH. All neonates with CDH admitted to our institution between 2010 until 2020 and undergoing ECMO treatment were included in this study and divided into four different groups: (1) ECMO initiation < 12 h after birth ( ...
Tópico(s): Congenital Heart Disease Studies
2022 - Multidisciplinary Digital Publishing Institute | Children
Angel Santiago Fernandez‐Bou, José M. Rodríguez-Flores, Alexander Guzman, J. Pablo Ortiz‐Partida, Leticia Classen‐Rodríguez, Pedro Andres Sanchez Perez, Jorge Valero-Fandiño, Chantelise Pells, Humberto Flores-Landeros, Samuel Sandoval‐Solis, Gregory W. Characklis, Thomas C. Harmon, Michael E. McCullough, Josué Medellín–Azuara,
Low-income, rural frontline communities of California's Central Valley experience environmental and socioeconomic injustice, water insecurity, extremely poor air quality, and lack of fundamental infrastructure (sewage, green areas, health services), which makes them less resilient. Many communities depend financially on agriculture, while water scarcity and associated policy may trigger farmland retirement further hindering socioeconomic opportunities. Here we propose a multi-benefit framework to ...
Tópico(s): Economic and Environmental Valuation
2022 - Elsevier BV | The Science of The Total Environment
Sayaka Kayumi, Luis A. Pérez‐Jurado, María Palomares‐Bralo, Sneha Rangu, Sarah E. Sheppard, Wendy K. Chung, Michael C. Kruer, Mira Kharbanda, David J. Amor, George McGillivray, Julie S. Cohen, Sixto García‐Miñaúr, Clare L. van Eyk, Kelly Harper, Lachlan A. Jolly, Dani L. Webber, Christopher Barnett, Fernando Santos‐Simarro, Marta Pacio‐Míguez, Ángela del Pozo, Somayeh Bakhtiari, Matthew A. Deardorff, Holly Dubbs, Kosuke Izumi, Katheryn Grand, Christopher Gray, Paul R. Mark, Elizabeth Bhoj, Dong Li, Xilma R. Ortiz‐González, Beth Keena, Elaine H. Zackai, Ethan M. Goldberg, Guiomar Pérez de Nanclares, Arrate Pereda, Isabel Llano‐Rivas, Ignacio Arroyo, María Ángeles Fernández-Cuesta, Christel Thauvin‐Robinet, Laurence Faivre, Aurore Garde, Benoît Mazel, Ange‐Line Bruel, Michael L. Tress, Eva H. Brilstra, Amena Smith Fine, Kylie Crompton, Alexander P.A. Stegmann, Margje Sinnema, Servi J.C. Stevens, Joost Nicolai, Gaëtan Lesca, Laurence Lion‐François, Damien Haye, Nicolas Chatron, Amélie Piton, Mathilde Nizon, Benjamin Cogné, Siddharth Srivastava, Jennifer A. Bassetti, Candace Muss, Karen W. Gripp, Rebecca Procopio, Francisca Millan, Michelle M. Morrow, Melissa Assaf, Andrés Moreno-De-Luca, Shelagh Joss, Mark Hamilton, M. Bertoli, Nicola Foulds, Shane McKee, Alastair H. MacLennan, Jozef Gécz, Mark Corbett,
Germline loss-of-function variants in CTNNB1 cause neurodevelopmental disorder with spastic diplegia and visual defects (NEDSDV; OMIM 615075) and are the most frequent, recurrent monogenic cause of cerebral palsy (CP). We investigated the range of clinical phenotypes owing to disruptions of CTNNB1 to determine the association between NEDSDV and CP.Genetic information from 404 individuals with collectively 392 pathogenic CTNNB1 variants were ascertained for the study. From these, detailed phenotypes ...
Tópico(s): Autism Spectrum Disorder Research
2022 - Elsevier BV | Genetics in Medicine
Juan Casado, Marek Z. Zgierski, Paul C. Ewbank, Michael W. Burand, Daron E. Janzen, Kent R. Mann, Ted M. Pappenfus, Anna Berlin, Ezequiel Pérez‐Inestrosa, Rocío Ponce Ortiz, Juan T. López Navarrete,
We analyze the electronic and molecular structures for the ground and excited electronic states of aromatic terthiophene (3T), the quinodimethane 3',4'-dibutyl-5,5' '-bis(dicyanomethylene)-5,5' '-dihydro-2,2':5',2' '-terthiophene (3Q), and isologues with the middle ring S-oxidized (3TO2, 3QO2). These represent extremes of electron rich and deficient ground states, often exhibiting complementary properties. Oxidizing the central sulfur atom affects the molecular structure, electron affinity, and photophysical ...
Tópico(s): Conducting polymers and applications
2006 - American Chemical Society | Journal of the American Chemical Society
Lennox J. Jeffers, Guido O. Pérez, Maria de Medina, Carmen Ortiz-Interian, Eugene R. Schiff, K. Rajender Reddy, Margarita Jimenez, Jacques J. Bourgoignie, Carlos A. Vaamonde, Robert Duncan, Michael Houghton, G.H. Choo, George Kuo,
We determined the prevalence of antibodies to the hepatitis C virus (anti-HCV) in 90 patients and 37 staff members of two hemodialysis units utilizing a recently developed anti-HCV recombinant based assay. Eleven patients (12%) were anti-HCV(+). Of these, eight (73%) had antibodies to the hepatitis B core antigen (anti-HBc) indicating prior hepatitis B infection; one patient was hepatitis B surface antigen (HBsAg)(+). All staff members were anti-HCV(-), although seven (19%) of them were anti-HBc(+). Alanine ...
Tópico(s): Liver Disease Diagnosis and Treatment
1990 - Elsevier BV | Kidney International
Anne-Carolin Döring, Michiel G.J.S. Hageman, Frans J. Mulder, Thierry G. Guitton, David Ring, Julie E. Adams, Joshua M. Abzug, Ngozi M. Akabudike, L.C. Bainbridge, George W Balfour, H. Brent Bamberger, Camilo Jose Romero Barreto, Michael A. Baskies, Taizoon Baxamusa, Michael J. Behrman, Prosper Benhaim, Philip Blazar, James M. Boler, Jorge G. Boretto, Martin I. Boyer, Ryan P. Calfee, Charles Cassidy, Ralp M. Costanzo, Michael Darowish, Ramon de Bedout, Gregory L. DeSilva, José Fernando Di Giovanni, Seth D. Dodds, John Erickson, Naquira Escobar Luis Felipe, Carlos Henrique Fernandes, Renato Fricker, Gary K. Frykman, Aida E. Garcia, R. Glenn Gaston, Richard S. Gilbert, Michael Grafe, Jeffrey A. Greenberg, Hans Grünwald, Paul M. Guidera, Warren C. Hammert, Randy M. Hauck, Steve Helgemo, Germán Hernández, Erik H. Hofmeister, Richard L. Hutchison, Asif M. Ilyas, Sidney M. Jacoby, Peter Jebson, Christopher M. Jones, Sanjeev Kakar, F. Thomas D. Kaplan, Saul J. Kaplan, Leonid I. Katolik, Stephen A. Kennedy, Michael W. Kessler, Hervey L. Kimball, Dan Kirkpatrick, Ryan Klinefelter, Gerald Kraan, Lewis Lane, Lisa Lattanza, Kendrick Lee, Kevin J. Malone, Chad Manke, Paul A. Martineau, Jim Matiko, John A. McAuliffe, Steven J. McCabe, Desirae McKee, Charles Metzger, Scott Mitchell, Jennifer Moriatis Wolf, Michael Nancollas, David L. Nelson, Jose Nolla, R. Nyszkiewicz, José Alfredo Soto Ortíz, Joachim P. Overbeck, Patrick Owens, Rick F. Papandrea, Lior Paz, Alberto Pérez Castillo, Daniel B. Polatsch, Gary M. Press, Marc J. Richard, Marco Rizzo, Tamara D. Rozental, David E. Ruchelsman, Oleg M. Semenkin, Russell A. Shatford, Fransisco Javier Aguilar Sierra, Todd E. Siff, Catherine Spath, S. Spruijt, Ben Sutker, Carrie R. Swigart, John S. Taras, Jason D. Tavakolian, Andrew L. Terrono, Eric T. Tolo, Christopher J. Walsh, Frank L. Walter, Barry Watkins, Lawrence Weiss, Brian P.D. Wills, Chris Wilson, Christophe J. Wilson, Jeffrey Wint, Colby Young,
Purpose To test the null hypothesis that there are no differences in the priorities and preferences of patients with idiopathic trigger finger (TF) and hand surgeons. Methods One hundred five hand surgeons of the Science of Variation Group and 84 patients with TF completed a survey about their priorities and preferences in decision making regarding the management of TF. The questionnaire was structured according the Ottawa Decision Support Framework for the development of a decision aid. Results ...
Tópico(s): Medical Malpractice and Liability Issues
2014 - Elsevier BV | The Journal Of Hand Surgery
Theo Vos, Christine A. Allen, Megha Arora, Ryan M Barber, Zulfiqar A Bhutta, Alexandria Brown, Austin Carter, Daniel Casey, Fiona J Charlson, Alan Z Chen, Megan Coggeshall, Leslie Cornaby, Lalit Dandona, Daniel Dicker, Tina Dilegge, Holly E Erskine, Alize J Ferrari, Christina Fitzmaurice, Tom Fleming, Mohammad H Forouzanfar, Nancy Fullman, Peter W. Gething, Ellen M Goldberg, Nicholas Graetz, Juanita A. Haagsma, Simon I Hay, Catherine O. Johnson, Nicholas J Kassebaum, Toana Kawashima, Laura Kemmer, Fakher Rahim, Yohannes Kinfu, Hmwe Hmwe Kyu, Janni Leung, Xiaofeng Liang, Stephen S Lim, Alan D López, Rafael Lozano, Laurie B. Marczak, George A. Mensah, Ali H. Mokdad, Mohsen Naghavi, Grant Nguyen, Elaine O. Nsoesie, Helen Elizabeth Olsen, David M. Pigott, Christine Pinho, Zane Rankin, Nikolas Reinig, Joshua A. Salomon, Logan Sandar, A. Gordon Smith, Jeffrey D Stanaway, Caitlyn Steiner, Stephanie Teeple, Bernadette A Thomas, Christopher Troeger, Joseph A. Wagner, Haidong Wang, Valentine Wanga, Harvey Whiteford, Leo Zoeckler, Amanuel Alemu Abajobir, Kalkidan Hassen Abate, Cristiana Abbafati, Kaja Abbas, Foad Abd-Allah, Biju Abraham, Ibrahim Abubakar, Laith J. Abu‐Raddad, Niveen M E Abu-Rmeileh, Ilana N. Ackerman, Akindele Olupelumi Adebiyi, Zanfina Ademi, Arsène Kouablan Adou, Kossivi Agbélénko Afanvi, Emilie Agardh, Arnav Agarwal, Ali Kiadaliri, Hamid Ahmadieh, Oluremi N Ajala, Rufus Akinyemi, Nadia Akseer, Ziyad Al‐Aly, Khurshid Alam, Noore Alam, Saleh Fahed Aldhahri, Miguel Angel Alegretti, Zewdie Aderaw Alemu, Lily Alexander, Samia Alhabib, Raghib Ali, Ala’a Alkerwi, François Alla, Peter Allebeck, Rajaa Al‐Raddadi, Ubai Alsharif, Khalid A Altirkawi, Nelson Alvis‐Guzmán, Azmeraw T. Amare, Alemayehu Amberbir, Heresh Amini, Walid Ammar, Stephen M. Amrock, Hjalte Holm Andersen, Gregory M. Anderson, Benjamin O. Anderson, Carl Abelardo T. Antonio, Atsede Fantahun Aregay, Johan Ärnlöv, Al Artaman, Hamid Asayesh, Reza Assadi, Suleman Atique, Euripide Frinel G Arthur Avokpaho, Ashish Awasthi, Beatriz Paulina Ayala Quintanilla, Peter Azzopardi, Umar Bacha, Alaa Badawi, Kalpana Balakrishnan, Amitava Banerjee, Aleksandra Barać, Suzanne Barker‐Collo, Till Bärnighausen, Lars Barregård, Lope H Barrero, Arindam Basu, Shahrzad Bazargan‐Hejazi, Ettore Beghi, Brent Bell, Michelle L. Bell, Derrick Bennett, Isabela M. Benseñor, Habib Benzian, Adugnaw Berhane, Eduardo Bernabé, Balem Demtsu Betsu, Addisu Shunu Beyene, Neeraj Bhala, Samir Bhatt, Sibhatu Biadgilign, Kelly Bienhoff, Boris Bikbov, Stan Biryukov, Donal Bisanzio, Espen Bjertness, Jed D Blore, Rohan Borschmann, Soufiane Boufous, Michael Brainin, Alexandra Bražinová, Nicholas J K Breitborde, Jonathan C. Brown, Rachelle Buchbinder, Geoffrey Buckle, Zahid A Butt, Bianca Calabria, Ismael Campos‐Nonato, Julio César Campuzano, Hélène Carabin, Rosario Cárdenas, David O. Carpenter, Juan Jesús Carrero, Carlos A Castañeda-Orjuela, Jacqueline Castillo Rivas, Ferrán Catalá-López, Jung‐Chen Chang, Peggy Pei-Chia Chiang, Chioma Ezinne Chibueze, Vesper Hichilombwe Chisumpa, Jee-Young Jasmine Choi, Rajiv Chowdhury, Hanne Christensen, Devasahayam Jesudas Christopher, Liliana G Ciobanu, Massimo Círillo, Matthew M Coates, Samantha Colquhoun, Cyrus Cooper, Monica Cortinovis, John A. Crump, Solomon Abrha Damtew, Rakhi Dandona, Farah Daoud, Paul I. Dargan, José das Neves, Gail Davey, Adrian Davis, Diego De Leo, Louisa Degenhardt, Liana C. Del Gobbo, Robert P Dellavalle, Kebede Deribe, Amare Deribew, Sarah Derrett, Don C. Des Jarlais, Samath D Dharmaratne, Preet K. Dhillon, Cèsar Díaz‐Torné, Eric L. Ding, Tim Driscoll, Leilei Duan, Manisha Dubey, Bruce Bartholow Duncan, Hedyeh Ebrahimi, Richard G. Ellenbogen, Iqbal Elyazar, Matthias Endres, Aman Yesuf Endries, Sergey Petrovich Ermakov, Babak Eshrati, Kara Estep, Talha Farid, Carla Sofia e Sá Farinha, André Faro, Maryam S. Farvid, Farshad Farzadfar, Valery L. Feigin, David T. Felson, Seyed‐Mohammad Fereshtehnejad, Jefferson Gomes Fernandes, João Carlos Fernandes, Florian Fischer, Joseph R A Fitchett, Kyle J Foreman, F. Gerry R. Fowkes, Jordan L. Fox, Richard C. Franklin, Joseph Friedman, Joseph Frostad, Thomas Fürst, Neal D. Futran, Belinda J. Gabbe, Parthasarathi Ganguly, Fortuné Gbètoho Gankpé, Teshome Gebre, Tsegaye Tewelde Gebrehiwot, Amanuel Tesfay Gebremedhin, Johanna M. Geleijnse, Bradford D. Gessner, Katherine B. Gibney, Ibrahim Ginawi, Ababi Zergaw Giref, Maurice Giroud, Melkamu Dedefo Gishu, Giorgia Giussani, Elizabeth Glaser, William W Godwin, Hector Gómez‐Dantés, Philimon Gona, Amador Goodridge, Sameer Vali Gopalani, Carolyn Gotay, Atsushi Goto, Hebe Gouda, Rebecca Grainger, Felix Greaves, Françis Guillemin, Yuming Guo, Rahul Gupta, Tarun Gupta, Vipin Gupta, Reyna Alma Gutiérrez, Demewoz Haile, Alemayehu Hailu, Gessessew Bugssa Hailu, Yara A. Halasa, Randah R Hamadeh, Samer Hamidi, Mouhanad Hammami, Jamie Hancock, Alexis J. Handal, Graeme J. Hankey, Yuantao Hao, Hilda L Harb, S Harikrishnan, Josep María Haro, Rasmus Havmoeller, Roderick J. Hay, Ileana Heredia-Pi, Pouria Heydarpour, Hans W. Hoek, Masako Horino, Nobuyuki Horita, Hung Chak Ho, Damian G Hoy, Aung Soe Htet, Hsiang Huang, John J Huang, Chantal Huynh, Marissa Iannarone, Kim Moesgaard Iburg, Kaire Innos, Manami Inoue, Veena Iyer,
Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, ...
Elsevier BV
Luis Ortiz‐Catedral, Dianne H. Brunton, Mark F. Stidworthy, Hany M. Elsheikha, Tom Pennycott, Christoph Schulze, Michael P. Braun, Michaël Wink, Helga Gerlach, Helene Pendl, Achim D. Gruber, John G. Ewen, Javier Pérez‐Tris, Gediminas Valkiūnas, Philipp Olias,
Haemoproteus and Plasmodium species are widespread avian blood parasites. Several Plasmodium species are known for their high virulence and have caused significant declines in naïve bird populations. The impact of closely related Haemoproteus parasites is largely unknown. Recently we reported a lethal disease in two parrot aviaries caused by Haemoproteus parasites. Here we show that the causative pathogen Haemoproteus minutus is responsible for further 17 lethal outbreaks in parrot aviaries in Denmark, ...
Tópico(s): Wildlife Conservation and Criminology Analyses
2019 - BioMed Central | Parasites & Vectors
Alfredo Hidalgo‐Miranda, Michael Baudis, Iver Petersen, Hugo Arreola, Patricia Piña‐Sánchez, Guelaguetza Vázquez-Ortíz, Dulce María Hernández Hernández, José Luis Blanco González, Minerva Lazos, Ricardo López, Carlos Pérez‐Plasencia, Jose D. Velazco‐Garcia, Karla Moreno Vázquez, Brenda Alatorre, Mauricio Salcedo,
Abstract Background Chromosomal Comparative Genomic Hybridization (CGH) has been applied to all stages of cervical carcinoma progression, defining a specific pattern of chromosomal imbalances in this tumor. However, given its limited spatial resolution, chromosomal CGH has offered only general information regarding the possible genetic targets of DNA copy number changes. Methods In order to further define specific DNA copy number changes in cervical cancer, we analyzed 20 cervical samples (3 pre-malignant ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2005 - BioMed Central | BMC Cancer
Produção Nacional
Revisado por pares
Cees J. Weeland, Selina Kasprzak, Niels T. de Joode, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul Arnold, Srinivas Balachander, Nerisa Banaj, Núria Bargalló, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Vilde Brecke, Silvia Brem, Carolina Cappi, Yuqi Cheng, Kang Ik K. Cho, Daniel L. Costa, Sara Dallaspezia, Damiaan Denys, Goi Khia Eng, Sónia Ferreira, Jamie D. Feusner, Martine Fontaine, Jean‐Paul Fouché, Rachael Grazioplene, Patricia Gruner, Mengxin He, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Hao Hu, Fern Jaspers‐Fayer, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lázaro, Chiang‐Shan R. Li, Christine Löchner, Rachel Marsh, Ignacio Martínez‐Zalacaín, David Mataix‐Cols, José M. Menchón, Luciano Minnuzi, Pedro Silva Moreira, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Ana E. Ortiz, Jose Ángel Pariente, John Piacentini, Maria Picó‐Pérez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y. C. Janardhan Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, H. Blair Simpson, Noam Soreni, Carles Soriano‐Mas, Nuno Sousa, Gianfranco Spalletta, Emily Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, Jumpei Takahashi, Tais Tanamatis, Jinsong Tang, Anders Lillevik Thorsen, David F. Tolin, Ysbrand D. van der Werf, Hein J. F. van Marle, Guido van Wingen, Daniela Vecchio, Ganesan Venkatasubramanian, Susanne Walitza, Jicai Wang, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je‐Yeon Yun, Qing Zhao, Tonya White, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Chris Vriend,
Abstract Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T 1 -weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2022 - Springer Nature | Translational Psychiatry
Eloy José Tarín-Vicente, Andrea Alemany, Manuel Agud‐Dios, María Ubals, Clara Suñer, Andrés Antón, Maider Arando, Jorge Arroyo‐Andrés, Lorena Calderón-Lozano, Cristina Casañ, José Miguel Cabrera, Pep Coll, Vicente Descalzo, María Dolores Folgueira, Jorge García, Elena Gil-Cruz, Borja González Rodríguez, Christian Gutiérrez‐Collar, Àgueda Hernández-Rodríguez, Paula López-Roa, María de los Ángeles Meléndez, Julia Montero‐Menárguez, Irene Muñoz‐Gallego, Sara Isabel Palencia Pérez, Roger Paredes, Alfredo Pérez‐Rivilla, María Piñana, Nuria Prat, Aída Ramírez, Ángel Rivero, Carmen Rubio‐Muñiz, Martí Vall, Kevin Stephen Acosta-Velásquez, An Wang, Cristina Galván‐Casas, Michael Marks, Pablo L. Ortiz‐Romero, Natàlia Casamitjana,
Summary Background In May, 2022, several European countries reported autochthonous cases of monkeypox, which rapidly spread globally. Early reports suggest atypical presentations. We aimed to investigate clinical and virological characteristics of cases of human monkeypox in Spain. Methods This multicentre, prospective, observational cohort study was done in three sexual health clinics in Madrid and Barcelona, Spain. We enrolled all consecutive patients with laboratory-confirmed monkeypox from May 11 to ...
Tópico(s): Bacillus and Francisella bacterial research
2022 - Elsevier BV | The Lancet
Montserrat Vera Llonch, Eunice Chang, Nowell M. Fine, José Nativi-Nicolau, Jose T. Ortiz‐Pérez, Michael Pollock, Sheila R. Reddy, Marian H. Tarbox,
Background Hereditary transthyretin amyloidosis (hATTR or ATTRv [variant]) is a progressive and fatal disease often associated with infiltrative cardiac involvement, with cardiac symptoms sometimes occurring years before diagnosis. Because there are available treatments for hATTR, prompt recognition and early diagnosis is imperative. Nurses who work closely with patients with heart failure are positioned to recognize the symptoms and early signs that should raise clinical suspicion and uncover an ...
Tópico(s): Parathyroid Disorders and Treatments
2021 - Elsevier BV | Heart & Lung