Jonathan Northcroft, Neil Wornnald, John Dugdale, William Kay, Barbara Hall, Nigel Botherway, Sebastian Faulks, N J, Christopher Higgins, Jim Munro, Peter Whittle, Helen Davies, Sally Brock, Rob Hughes, Jason Dawe, John Peter, Colin Brennan, Professor Gideon Garter, Leonard Gold, David Wilson, Lesley White, Andrew Longmore, Adam Sweeting, Adam Hathaway, Susan d'Arcy, Gareth Walsh, Richard Thomas, Mf Millward, Frank Whitford, Ivo Tennant, John Caulcutt founder of Watermark, David Blunkett, Caroline Brannigan, Sam Gilpin, Kathryn Cooper, Dom Joly, Andrew Taylor, William Lewis, David Silvester, David Smith, Gemma Stockford, Tim Richards, Bob Ganly, Ian Woosnam, Peter McGrath, David Cracknell Political Editor, Nick Pitt, Lucy Hughes-Hallett, Frederic Raphael, E P, Andrew Sullivan, Clive Davis, Andrew Porter, Pane Barrett, Tony Allen-Mills, Simon Wilde, Martin James, Gemma Scott-Martin, Tom Walker, Robert Winnett, Dipesh Gadher Transport Correspondent, Nina Hemstock, Michael Sheridan Ho Chi Minh City, Irwin Stelzer, Matt Rudd, Peter Wilson, Tom Farrall, Rosie Millard, Adrian Furnham, David Dougill, Pat Gilbert, Norman Davies, Robert Winnett Whitehall Correspondent, Mathew Court, Peter Van Stancomb, Stuart Barnes, Peter Jones, Stuart Rand-Bell, Rob Maul, David Hewson, Cally Law, Jonathon Carr-Brown, Hugh Canning, Geraldine Hackett Education Correspondent, Jeremy Clarkson, Victoria Segal, Edward Porter, Phil Spencer, David Cairns, Stewart Lee, Michael Portillo, Sarah Dempster, Ben Martin, Dave Pollard, Cheryl Tweedy, Kevin Jackson, Anita Chaudhuri, Nick Robinson, Richard Fletcher, Greg Struthers, Francis Brown, Phil Craigie, David Carr-Allinson, Jeff Potter, Jeremy Guscott, Sally Murfitt, Peter Parker, Mike Laws, Robin Scott-Elliot, Stuart Wavell, Gary Rhodes, Charles Chesshire, Paul Donovan, Christopher Silvester, Dianne Thompson Chief Executive, Tom Stubbs, Paul Kimmage, Giles Hattersley, Hugh McIlvanney, Chris Woodhead, Bernard Wright, Jasper Gerard, Paul Driver, Simon Davies, Guy Bewick, P D, Nicholas Hellen, Ian Hawkey, Joe Lovejoy football correspondent, Stuart Andrews, Gavin MacDonald, David Leppard, Shelley Von Strunckel, Paul Durman, Tom Avery, Mark Edwards, Tom Shone, Rachel Bridge, Irena Bojanowska, Susan Clark, Simon Jowett, Michael Winner, Peter Whitte, Steven Boyd, Roger Beam, Raymond Keene, C L, Gareth Huw Davies, Rod Liddle, Douglas Alexander, David Cracknell, Cosmo Landesman, Zoe Brennan, Diana Wright, Lindsay Wise Cairo, Nigel Kandzia, Helen Hawkins, Stephen Jones, Dominic O'Connell, Stephen Bleach, Barry Flatman, Uzi Mahnaimi, Nick Cain, Louise Armitstead, Andrew Holgate, Adrienne Connors, Natalie Graham, Caroline Donald, Brian Claridge, Nick Rennison, Rob Ryan, David Carins, Ian Critchley, David Walsh, Jack Grimston, Bryan Appleyard, Stephen Armstrong, John Elliott, Rob Hilliard, Colin McDowell's, Kenny Clemence, Mark Stucklin, Bethan Cole, Roger Panting, McGinty, Richard Woods, Roland White, Ruth Rendell, Shane Watson, Edwina, Amrit Dhillon, Maurice Chittenden, Margaret Clarke, Alex Fortune, Jonathan Clayton, Andy Moore, Judith O'Reilly, Mark Franchetti, Richard Rae, Peter Hunt, Ray Hutton, Dan Box, Clare Francis, Michael Smith, John Harlow, Godfrey Smith, John Cornwell, Roger Bloxham, John Waples, Elahe Mohtasham, Hunter Davies, A A Gill, Alex Pell, Kara O'Reilly, Matthew Campbell, Brian Glanville, Mel Giedroyc, Jeff Peter `, John Carey, David Horspool, Nick Fielding, Stephen Pettitt, Will Iredale, Jonathan Leake Science Editor, Steve Redmond, Jessica Bown, Gareth Davies, Nora Graham, Andrew Marshall, Jeremy Langmead, John Spurling, Sally Kinnes, Tom Pattinson, Naomi Caine, David Wickers, Daniel Emery, Roger Dobson, Brian Doogan, Ben Dowell, Minette Marrin, John Aizlewood, George Davis, Mark Hodson, Simon Kurs, Andrew Frankel, Ken Lunn, Joe Lovejoy, Jonathan Futrell, Graham Norwood, Clifford Bishop, David Budworth, Leslie Law, William Lewis Business editor, Andrew Davidson, Roy Salter, Clive Hetherington, Pete Oliver, Stan Rylett, Arthur Cubley, Hugh Pearman, Dan Cairns, Christopher Bray, Karan Robinson, Hugh Bradley, Alan Sugar, Lord Ezra, Rachel De Thame, Mrs Mills, Sarah Baxter, Brian Schofield, Hugh Robinson, Kate Spicer, Matthew Goodman, India Knight, Sara Hassan, Joanna Simon, Simon Reid, Ed Hughes, Barry Newcombe, Richard Lewis, Sian Griffiths, Karen Robinson, Helen Stewart,
... The top 10 Sporting sugar daddies 2 Kerry Pacher 3 Sir Jack Walker The Sunday Times 5 ... for man. The series starts with the captains. Michael Vaughan and Ricky Ponting. By Simon Wilde It ...
2005 - Gale Group | Sunday Times HA GDA
Gu ̈nter Klappacher, Patrick Franzen, Doris Haab, Mohammad Reza Mehrabi, Michael Binder, Karina Plesch, Richard Pacher, Michael Grimm, Ingrid Pribill, Hans‐Georg Eichler, Helmut D. Glogar,
Circulating levels of extracellular matrix components were measured by radioimmunoassays and tested if they were useful for clinical staging in chronic heart failure. In 41 patients with dilated cardiomyopathy (33 idiopathic and 8 ischemic cases), the serum concentrations of procollagen type III aminoterminal peptide (PIIINP), type I collagen telopeptide (ICTP), and basement membrane laminin were significantly higher than in 30 healthy controls regardless of the underlying etiology. Patients with serum ...
Tópico(s): Cardiac Valve Diseases and Treatments
1995 - Elsevier BV | The American Journal of Cardiology
Gottfried Heinz, C Kratochwill, Susanne Schmid, Gerhard Kreiner, Peter Siostrzonek, Richard Pacher, Michael Grimm, Günther Laufer, Heinz Gössinger,
In the present study, the annual incidence of postoperative sinus node dysfunction and the type of sinus node abnormality after cardiac transplantation were followed over a 6 1/2-year period in 185 patients. Each year the sinus node function was systematically characterized by rhythm and corrected sinus node recovery time in a significant number of patients. Over the entire study period, there were 131 patients with normal sinus node function (corrected sinus node recovery time 318 +/- 55 msec) while ...
Tópico(s): Mechanical Circulatory Support Devices
1994 - Wiley | Pacing and Clinical Electrophysiology
Katharina Kerschan‐Schindl, Margot Ruzicka, Stéphane Mahr, Matthias Paireder, Christian Krestan, Andreas Gleiß, Christian Bieglmayer, Veronika Fialka‐Moser, Richard Pacher, Michael Grimm, Peter Pietschmann,
Heart transplantation (HTX) is associated with a reduction in bone mineral density (BMD). Different markers of bone metabolism have been used, and the applied immunosuppressive regimens have also changed over time. This study was performed to re-investigate bone metabolism in HTX recipients. Twenty-five HTX recipients were compared with 25 HTX candidates in respect of biochemical parameters of bone metabolism, BMD, and the frequency of fractures for 1 year. Osteopenia or osteoporosis was observed ...
Tópico(s): Orthopaedic implants and arthroplasty
2007 - Springer Science+Business Media | Transplant International
Matthias Blüher, Stefan Engeli, Nora Klöting, Janin Berndt, Mathias Faßhauer, Sándor Bátkai, Pál Pacher, Michael P. Schön, Jens Jordan, Michael Stümvoll,
The endocannabinoid system has been suspected to contribute to the association of visceral fat accumulation with metabolic diseases. We determined whether circulating endocannabinoids are related to visceral adipose tissue mass in lean, subcutaneous obese, and visceral obese subjects (10 men and 10 women in each group). We further measured expression of the cannabinoid type 1 (CB1) receptor and fatty acid amide hydrolase (FAAH) genes in paired samples of subcutaneous and visceral adipose tissue in ...
Tópico(s): Dietary Effects on Health
2006 - American Diabetes Association | Diabetes
Margit Pacher, Michael J. Seewald, Mario Mikula, Susanne Oehler, Maurice Mogg, Ursula Vinatzer, Andreas Eger, Norbert Schweifer, Roland Varecka, Wolfgang Sommergruber, Wolfgang Mikulits, Martin Schreiber,
Insulin-like growth factor (IGF) signaling is a key regulator of breast development and breast cancer. We have analyzed the expression of the IGF signaling cascade in 17 human breast cancer and 4 mammary epithelial cell lines. Five cell lines expressed high levels of IGF1 receptor, insulin (INS)/IGF receptor substrate 1, IGF-binding proteins 2 and 4, as well as the estrogen receptor (ESR), indicating a co-activation of IGF and ESR signaling. Next, we stably overexpressed IGF1 and IGF2 in MCF7 breast ...
Tópico(s): Digestive system and related health
2006 - Oxford University Press | Carcinogenesis
Ursula Vinatzer, Brigitta Dampier, Berthold Streubel, Margit Pacher, Michael J. Seewald, Christian Stratowa, Klaus Kaserer, Martin Schreiber,
Accurate testing of HER2 is centrally important for breast cancer therapy and prognosis. Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are current standard testing methods. As a potential alternative for assessment of HER2, we explored quantitative real-time reverse transcription-PCR (RT-PCR), a fast and inexpensive method yielding quantitative results insensitive to interobserver variability and amenable to standardized scoring.We assessed HER2 status at the DNA, mRNA, and ...
Tópico(s): Glycosylation and Glycoproteins Research
2005 - American Association for Cancer Research | Clinical Cancer Research
Dorian Bevec, Herbert Jaksche, Martin Oft, Thorsten Wöhl, Michèle Himmelspach, Alexandra Pacher, Michael Schebesta, Karl Koettnitz, Marika Dobrovnik, Robert Csonga, Friedrich Lottspeich, Joachim Hauber,
Eukaryotic initiation factor 5A(eIF-5A) is a cellular cofactor require d for the function of the human immunodeficiency virus type-1 (HIV-1) Rev trans-activator protein. The majority of a set of eIF-5A mutants did not support growth of yeast cells having an inactivated genomic copy of eIF-5A, indicating that the introduced mutation eliminated eIF-5A activity. Two nonfunctional mutants, eIF-5AM13 and eIF-5AM14, retained their binding capacity for the HIV-1 Rev response element:Rev complex. Both mutants ...
Tópico(s): Bacteriophages and microbial interactions
1996 - American Association for the Advancement of Science | Science
Ghazaleh Gouya, P. Voithofer, Stephanie Neuhold, Angela Storka, Greisa Vila, Richard Pacher, Michael Wolzt, Martin Hülsmann,
International Journal of Clinical PracticeVolume 68, Issue 11 p. 1293-1300 Original Paper Association of nutritional risk index with metabolic biomarkers, appetite-regulatory hormones and inflammatory biomarkers and outcome in patients with chronic heart failure G. Gouya, Corresponding Author G. Gouya Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria Correspondence to: Ghazaleh Gouya, MD, Medizinische Universität Wien, Universitätsklinik für Klinische Pharmakologie, ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2014 - Wiley | International Journal of Clinical Practice
Ghazaleh Gouya, Jolanta M. Siller‐Matula, Monika Fritzer‐Szekeres, Stephanie Neuhold, Angela Storka, Lisa Maria Neuhofer, Martin Clodi, Martin Hülsmann, Richard Pacher, Michael Wolzt,
Experimental data imply that in decompensated heart failure (HF), the anti-angiogenic factor endostatin is increased. This study aimed to investigate whether the angiogenesis inhibitor endostatin is related to the risk of all-cause mortality in a prospective cohort study of chronic HF patients.In this prospective observational cohort study, endostatin serum concentrations were determined in patients with chronic HF. Mortality data were recorded during a median follow-up of 31 months.One fifty one ...
Tópico(s): Cardiovascular Function and Risk Factors
2013 - Wiley | European Journal of Clinical Investigation
Georg Wieselthaler, Heinrich Schima, Andrea Lassnigg, Martin Dworschak, Richard Pacher, Michael Grimm, Ernst Wolner,
Background. The bridge to transplantation with pulsatile mechanical assist devices became a standard procedure for patients deteriorating on the waiting list. Recently, continuous flow axial impeller pumps were introduced to clinical application offering new advantages. Methods. From November 1998 till September 2000, 6 male patients (mean age 53 plus or minus 11 years) with end-stage left heart failure were implanted with a DeBakey ventricular assist device (VAD) axial-flow pump for bridge to transplantation. ...
Tópico(s): Cardiac pacing and defibrillation studies
2001 - Elsevier BV | The Annals of Thoracic Surgery
Fabian Laudenbach, Bernhard Schrenk, Christoph Pacher, Michael Hentschel, Chi‐Hang Fred Fung, Fotini Karinou, Andreas Poppe, Momtchil Peev, Hannes Hübel,
We present a pilot-assisted coherent intradyne reception methodology for CV-QKD with true local oscillator. An optically phase-locked reference tone, prepared using carrier-suppressed optical single-sideband modulation, is multiplexed in polarisation and frequency to the 250 Mbaud quantum signal in order to provide optical frequency- and phase matching between quantum signal and local oscillator. Our concept allows for high symbol rates and can be operated at an extremely low excess-noise level, ...
Tópico(s): Advanced Fiber Laser Technologies
2019 - Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften | Quantum
C. Eing, Simone Bonnet, Michael Pacher, Holger Puchta, Wolfgang Frey,
Seven days old seedlings of Arabidopsis thaliana, suspended in a 0.4 S/m buffer solution were exposed to nanosecond pulsed electric fields (nsPEF) with a duration of 10 ns, 25 ns and 100 ns. The electric field was varied from 5 kV/cm up to 50 kV/cm. The specific treatment energy ranged between 100 J/kg and 10 kJ/kg. Due to electroporation of the plasma membrane of the plant cells, the seedlings completely died off, when 100 ns pulses and high electric field pulses were applied. But even at the highest ...
Tópico(s): Plant Genetic and Mutation Studies
2009 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Dielectrics and Electrical Insulation
Koichi Watanabe, Michael Pacher, Stefanie Dukowic‐Schulze, Veit Schubert, Holger Puchta, Ingo Schubert,
Sister chromatids are often arranged as incompletely aligned entities in interphase nuclei of Arabidopsis thaliana. The STRUCTURAL MAINTENANCE OF CHROMOSOMES (SMC) 5/6 complex, together with cohesin, is involved in double-strand break (DSB) repair by sister chromatid recombination in yeasts and mammals. Here, we analyzed the function of genes in Arabidopsis. The wild-type allele of SMC5 is essential for seed development. Each of the two SMC6 homologs of Arabidopsis is required for efficient repair ...
Tópico(s): Plant Genetic and Mutation Studies
2009 - Oxford University Press | The Plant Cell
... and application: the significance of the sources of Michael Pacher's altarpieces MARK EVANS 7. Fra Bartolomeo's ...
Tópico(s): Historical Art and Architecture Studies
1992 - Truman State University | Sixteenth Century Journal
Anja Mannuß, Stefanie Dukowic‐Schulze, Stefanie Suer, Frank Hartung, Michael Pacher, Holger Puchta,
Abstract Complex DNA structures, such as double Holliday junctions and stalled replication forks, arise during DNA replication and DNA repair. Factors processing these intermediates include the endonuclease MUS81, helicases of the RecQ family, and the yeast SNF2 ATPase RAD5 and its Arabidopsis thaliana homolog RAD5A. By testing sensitivity of mutant plants to DNA-damaging agents, we defined the roles of these factors in Arabidopsis. rad5A recq4A and rad5A mus81 double mutants are more sensitive ...
Tópico(s): Genomics and Chromatin Dynamics
2010 - Oxford University Press | The Plant Cell
Katharina Seeliger, Stefanie Dukowic‐Schulze, Rebecca Wurz‐Wildersinn, Michael Pacher, Holger Puchta,
• Mutations in the breast cancer susceptibility gene 2 (BRCA2) are correlated with hereditary breast cancer in humans. Studies have revealed that mammalian BRCA2 plays crucial roles in DNA repair. Therefore, we wished to define the role of the BRCA2 homologs in Arabidopsis in detail. • As Arabidopsis contains two functional BRCA2 homologs, an Atbrca2 double mutant was generated and analyzed with respect to hypersensitivity to genotoxic agents and recombination frequencies. Cytological studies addressing male ...
Tópico(s): Photosynthetic Processes and Mechanisms
2011 - Wiley | New Phytologist
Michael Pacher, Waltraud Schmidt-Puchta, Holger Puchta,
Using the rare-cutting endonuclease I-SceI we were able to demonstrate before that the repair of a single double-strand break (DSB) in a plant genome can be mutagenic due to insertions and deletions. However, during replication or due to irradiation several breaks might be induced simultaneously. To analyze the mutagenic potential of such a situation we established an experimental system in tobacco harboring two unlinked transgenes, each carrying an I-SceI site. After transient expression of I-SceI ...
Tópico(s): Plant tissue culture and regeneration
2006 - Oxford University Press | Genetics
Friedrich Fauser, Nadine Roth, Michael Pacher, Gabriele Ilg, Rocı́o Sánchez-Fernández, Christian Biesgen, Holger Puchta,
The development of designed site-specific endonucleases boosted the establishment of gene targeting (GT) techniques in a row of different species. However, the methods described in plants require a highly efficient transformation and regeneration procedure and, therefore, can be applied to very few species. Here, we describe a highly efficient GT system that is suitable for all transformable plants regardless of transformation efficiency. Efficient in planta GT was achieved in Arabidopsis thaliana ...
Tópico(s): Plant tissue culture and regeneration
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Nadine Roth, Jacqueline Klimesch, Stefanie Dukowic‐Schulze, Michael Pacher, Anja Mannuß, Holger Puchta,
In recent years, multiple factors involved in DNA double-strand break (DSB) repair have been characterised in Arabidopsis thaliana. Using homologous sequences in somatic cells, DSBs are mainly repaired by two different pathways: synthesis-dependent strand annealing (SDSA) and single-strand annealing (SSA). By applying recombination substrates in which recombination is initiated by the induction of a site-specific DSB by the homing endonuclease I-SceI, we were able to characterise the involvement of ...
Tópico(s): Plant Genetic and Mutation Studies
2012 - Wiley | The Plant Journal
Michael Pacher, Holger Puchta,
Summary Production of mutants of crop plants by the use of chemical or physical genotoxins has a long tradition. These factors induce the natural DNA repair machinery to repair damage in an error‐prone way. In the case of radiation, multiple double‐strand breaks ( DSB s) are induced randomly in the genome, leading in very rare cases to a desirable phenotype. In recent years the use of synthetic, site‐directed nucleases ( SDN s) – also referred to as sequence‐specific nucleases – like the CRISPR /Cas system ...
Tópico(s): Plant Virus Research Studies
2016 - Wiley | The Plant Journal
Jochen Kumlehn, Janine Pietralla, Göetz Hensel, Michael Pacher, Holger Puchta,
Since the discovery that nucleases of the bacterial CRISPR (clustered regularly interspaced palindromic repeat)-associated (Cas) system can be used as easily programmable tools for genome engineering, their application massively transformed different areas of plant biology. In this review, we assess the current state of their use for crop breeding to incorporate attractive new agronomical traits into specific cultivars of various crop plants. This can be achieved by the use of Cas9/12 nucleases for ...
Tópico(s): Insect symbiosis and bacterial influences
2018 - Wiley | Journal of Integrative Plant Biology
Carla Schmidt, Michael Pacher, Holger Puchta,
Genome engineering is a biotechnological approach to precisely modify the genetic code of a given organism in order to change the context of an existing sequence or to create new genetic resources, e.g., for obtaining improved traits or performance. Efficient targeted genome alterations are mainly based on the induction of DNA double-strand breaks (DSBs) or adjacent single-strand breaks (SSBs). Naturally, all organisms continuously have to deal with DNA-damaging factors challenging the genetic integrity, ...
Tópico(s): Plant tissue culture and regeneration
2018 - Springer Science+Business Media | Methods in molecular biology
Carla Schmidt, Michael Pacher, Holger Puchta,
Summary During the evolution of plant genomes, sequence inversions occurred repeatedly making the respective regions inaccessible for meiotic recombination and thus for breeding. Therefore, it is important to develop technologies that allow the induction of inversions within chromosomes in a directed and efficient manner. Using the Cas9 nuclease from Staphylococcus aureus ( Sa Cas9), we were able to obtain scarless heritable inversions with high efficiency in the model plant Arabidopsis thaliana . Via ...
Tópico(s): Plant Virus Research Studies
2019 - Wiley | The Plant Journal
Natalja Beying, Carla Schmidt, Michael Pacher, Andreas Houben, Holger Puchta,
Tópico(s): Plant Virus Research Studies
2020 - Nature Portfolio | Nature Plants
Richard Crevenna, Winfried Mayr, Mohammad Kéilani, Johannes Pleiner, Martin Nuhr, Michael Quittan, Richard Pacher, Veronika Fialka‐Moser, Michael Wolzt,
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2003 - Springer Science+Business Media | Wiener klinische Wochenschrift
Richard Pacher, Michael Frass, Engelbert Hartter, W. Woloszczuk, Christian Leithner,
The levels of alpha-atrial natriuretic peptide (ANP) in the right atrium, pulmonary artery, radial artery, and superior vena cava plasma were measured by radioimmunoassay in eight patients with volume-expansion due to different diseases. The alpha-ANP levels were significantly increased, but became decreased after fluid removal by continuous veno-venous hemofiltration. When all alpha-ANP concentrations of different anatomical locations and hemodynamic variables were grouped, pulmonary capillary wedge ...
Tópico(s): Mechanical Circulatory Support Devices
1986 - Lippincott Williams & Wilkins | Critical Care Medicine
Richard Crevenna, Michael Wolzt, Veronika Fialka‐Moser, Mohammad Kéilani, Martin Nuhr, Tatjana Paternostro‐Sluga, Richard Pacher, Winfried Mayr, Michael Quittan,
Neuromuscular electrical stimulation (NMES) is an option for increasing thigh muscle strength and endurance capacity in patients with chronic heart failure. Electromagnetic interference (EMI) by the signals with sensing of implantable cardioverter defibrillators (ICDs) is possible. The aim of the present pilot safety study was to test the safety of a long-term NMES in patients with ICDs. Six patients with subpectoral ICDs were subjected to long-term NMES of thigh muscles. Four inpatients received NMES ...
Tópico(s): Neuroscience and Neural Engineering
2004 - Wiley | Artificial Organs
Richard Pacher, Heinz Redl, Michael Frass, D. H. Petzl, Ernst Schuster, W. Woloszczuk,
In a series of 56 patients (24 uncomplicated postoperative and 32 septic patients), neopterin and elastase alpha 1 protease inhibitor complex (E-alpha 1 PI) plasma levels were measured daily. The clinical course of each patient was evaluated with the Multiple Organ Failure (MOF) score according to Goris. Neopterin could differentiate between septic and nonseptic patients (p less than .001), and E-alpha 1 PI between septic nonsurvivors and nonseptic patients only (p less than .01). In septic patients, acute ...
Tópico(s): Adrenal Hormones and Disorders
1989 - Lippincott Williams & Wilkins | Critical Care Medicine
Richard Pacher, Sebastian Globits, Michael Wutte, Suzanne Rödler, Gottfried Heinz, Gerhard Kreiner, Susanne Radosztics, Rudolf Berger, Isabella Presch, H. Wéber,
Objective To study the hemodynamic effects of prostaglandin E1: (PGE1)administered in addition to a standard catecholamine infusion in patients with severe chronic heart failure. Design Prospective, placebo-controlled, randomized, single-blind study. Setting Intensive care unit at a university hospital. Patients Thirty patients with severe chronic heart failure, New York Heart Association functional class TV (28 men, two women, with a mean age of 54 ± 2 yrs, mean left ventricular ejection fraction 10 ± ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1994 - Lippincott Williams & Wilkins | Critical Care Medicine