Paul L. Soto, Kristin M. Wilcox, Yun Zhou, Nancy A. Ator, Mark A. Riddle, Dean F. Wong, Michael R. Weed,
The stimulants methylphenidate and amphetamine are used to treat children with attention deficit/hyperactivity disorder over important developmental periods, prompting concerns regarding possible long-term health impact. This study assessed the effects of such a regimen in male, peri-adolescent rhesus monkeys on a variety of cognitive/behavioral, physiological, and in vivo neurochemical imaging parameters. Twice daily (0900 and 1200 hours), for a total of 18 months, juvenile male monkeys (8 per group) ...
Tópico(s): Functional Brain Connectivity Studies
2012 - Springer Nature | Neuropsychopharmacology
Zachary T. Freeman, Kelly A. Rice, Paul L. Soto, Kelly A. Metcalf Pate, Michael R. Weed, Nancy A. Ator, Iser G. DeLeon, Dean F. Wong, Yun Zhou, Joseph L. Mankowski, M. Christine Zink, Robert J. Adams, Eric K. Hutchinson,
Abstract Self-injurious behavior (SIB) is a common comorbidity of psychiatric disorders but there is a dearth of information about neurological mechanisms underlying the behavior, and few animal models exist. SIB in humans is characterized by any intentional self-directed behavior that leads to wounds, whereas in macaques it is not always accompanied by wounds. We describe a cohort of rhesus macaques displaying SIB as adults, in which changes within the central nervous system were associated with ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2015 - Springer Nature | Translational Psychiatry
Paul L. Soto, Kristin M. Wilcox, Yun Zhou, Nancy A. Ator, Mark A. Riddle, Dean F. Wong, Michael R. Weed,
Correction to: Neuropsychopharmacology (2012) 37, 2566–2579; doi:10.1038/npp.2012.119; published online 18 July 2012 In this article, Dr Anil Kumar of the Department of Radiology and Radiological Science, Johns Hopkins School of Medicine was inadvertently omitted from the byline. The list of authorsshould read: Paul L Soto1, Kristin M Wilcox1, Yun Zhou2, Anil Kumar2, Nancy A Ator1, Mark A Riddle1*, Dean F Wong1,2,3,4,5 and Michael R Weed1.
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2013 - Springer Nature | Neuropsychopharmacology