Guillaume Sandoz, Susanne Thümmler, Fabrice Duprat, Sylvain Féliciangéli, Joëlle Vinh, Pierre Escoubas, Nicolas Guy, Michel Lazdunski, Florian Lesage,
... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS ... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR6097, Institut Paul Hamel, Valbonne, France Search for more papers by this author Florian Lesage Corresponding Author Florian Lesage Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR6097, Institut Paul Hamel, Valbonne, France Search for more papers by this author Author Information Guillaume Sandoz1,‡, Susanne Thümmler1,‡, Fabrice Duprat1, Sylvain Feliciangeli1, Joëlle Vinh2, Pierre Escoubas1, Nicolas Guy1, Michel Lazdunski1 and Florian Lesage 1 1Institut de Pharmacologie ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2006 - Springer Nature | The EMBO Journal
Juliette Descoeur, Vanessa Pereira, Anne Pizzoccaro, Amaury François, Bing Ling, Violette Maffre, Brigitte Couette, Jérôme Busserolles, Christine Courteix, Jacques Noël, Michel Lazdunski, Alain Eschalier, Nicolas Authier, Emmanuel Bourinet,
... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, ... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, UMR ...
Tópico(s): Respiratory and Cough-Related Research
2011 - Springer Nature | EMBO Molecular Medicine
Mallorie Poët, Michel Tauc, Éric Lingueglia, Peggy Cance, Philippe Poujeol, Michel Lazdunski, Laurent Counillon,
... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS ... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR6097, ...
Tópico(s): Ion Transport and Channel Regulation
2001 - Springer Nature | The EMBO Journal
Michel Lazdunski, Christian Frelin, Jacques Barhanin, Alain Lombet, Hamutal Meiri, David Pauron, Georges Romey, Annie Schmid‐Alliana, Hugues Schweitz, Paul Vigne, Henk P.M. Vijverberg,
... Tools to Study Voltage-Sensitive Na+ Channelsa MICHEL LAZDUNSKI, MICHEL LAZDUNSKI Centre de Biochimie du Centre National de ... Search for more papers by this author MICHEL LAZDUNSKI, MICHEL LAZDUNSKI Centre de Biochimie du Centre National de la ...
Tópico(s): Ion Transport and Channel Regulation
1986 - Wiley | Annals of the New York Academy of Sciences
Emmanuel Deval, Jacques Noël, Nadège Lay, Abdelkrim Alloui, Sylvie Diochot, Valérie Friend, Martine Jodar, Michel Lazdunski, Éric Lingueglia,
... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, UMR ... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, UMR 6097 ...
Tópico(s): Ion Channels and Receptors
2008 - Springer Nature | The EMBO Journal
... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS- ... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UPR ...
Tópico(s): Neuroscience and Neuropharmacology Research
2001 - Springer Nature | The EMBO Journal
... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS ... Search for more papers by this author Michel Lazdunski Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UPR ...
Tópico(s): Cardiac pacing and defibrillation studies
2000 - Springer Nature | The EMBO Journal
Terry B. Rogers, Michel Lazdunski,
... USA Search for more papers by this authorMichel Lazdunski, Michel Lazdunski Centre de Biochimie, Université de Nice, Parc ... USA Search for more papers by this authorMichel Lazdunski, Michel Lazdunski Centre de Biochimie, Université de Nice, Parc Valrose, ...
Tópico(s): Enzyme Catalysis and Immobilization
1979 - Wiley | FEBS Letters
Jean‐Pierre Vincent, M. Balerna, Michel Lazdunski,
... Nice, FranceSearch for more papers by this authorMichel Lazdunski, Michel Lazdunski Centre de Biochimie, Faculté des Sciences, Université ... Nice, FranceSearch for more papers by this authorMichel Lazdunski, Michel Lazdunski Centre de Biochimie, Faculté des Sciences, Université de ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
1978 - Wiley | FEBS Letters
Jean‐Pierre Vincent, Michel Lazdunski,
... Nice, FranceSearch for more papers by this authorMichel Lazdunski, Michel Lazdunski Centre de Biochimie, Faculté des Sciences, Université ... Nice, FranceSearch for more papers by this authorMichel Lazdunski, Michel Lazdunski Centre de Biochimie, Faculté des Sciences, Université de ...
Tópico(s): Galectins and Cancer Biology
1976 - Wiley | FEBS Letters
Michel Lazdunski, Jacques Barhanin, Marc Borsotto, CHRISTIAN COGNARD, CHRISTIE COOPER, Thierry Coppola, Michel Fosset, Jean‐Pierre Galizzi, MARLENE M. HOSEY, Christiane Mourre, Jean‐François Renaud, G. Romey, Annie Schmid‐Alliana, Sylvie Vandaele,
... Structure and Regulation of the Calcium Channela MICHEL LAZDUNSKI, MICHEL LAZDUNSKI Biochemistry Center National Center for Scientific Research ( ... FranceSearch for more papers by this author MICHEL LAZDUNSKI, MICHEL LAZDUNSKI Biochemistry Center National Center for Scientific Research (CNRS) ...
Tópico(s): Neuroscience and Neuropharmacology Research
1988 - Wiley | Annals of the New York Academy of Sciences
Florian Lesage, Jean‐Philippe Hugnot, Ez‐Zoubir Amri, Paul A. Grimaldi, Jacques Barhanin, Michel Lazdunski,
... author on: Oxford Academic PubMed Google Scholar Michel Lazdunski Michel Lazdunski * *To whom correspondence should be addressed Search for ...
Tópico(s): Genomics and Chromatin Dynamics
1994 - Oxford University Press | Nucleic Acids Research
Inger Lauritzen, Nicolas Blondeau, Catherine Heurteaux, Catherine Widmann, Georges Romey, Michel Lazdunski,
... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS ... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UPR ... Blondeau1, Catherine Heurteaux1, Catherine Widmann1, Georges Romey1 and Michel Lazdunski 1 1Institut de Pharmacologie Moléculaire et Cellulaire, CNRS ...
Tópico(s): Biochemical effects in animals
2000 - Springer Nature | The EMBO Journal
Sylvie Diochot, Anne Baron, Lachlan D. Rash, Emmanuel Deval, Pierre Escoubas, Sabine Scarzello, Miguel Salinas, Michel Lazdunski,
... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, Centre ... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, Centre National ... Deval1, Pierre Escoubas1, Sabine Scarzello1, Miguel Salinas1 and Michel Lazdunski 1 1Institut de Pharmacologie Moléculaire et Cellulaire, Centre ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2004 - Springer Nature | The EMBO Journal
Abdelkrim Alloui, Katharina Zimmermann, Julien Mamet, Fabrice Duprat, Jacques Noël, Jean Chemin, Nicolas Guy, Nicolas Blondeau, Nicolas Voilley, Cathérine Rubat-Coudert, Marc Borsotto, Georges Romey, Catherine Heurteaux, Peter W. Reeh, Alain Eschalier, Michel Lazdunski,
... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS- ... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-Université ... Romey3, Catherine Heurteaux3, Peter Reeh2, Alain Eschalier1 and Michel Lazdunski 3 1Laboratoire de Pharmacologie Médicale EA 3848 INSERM/ ...
Tópico(s): Ion channel regulation and function
2006 - Springer Nature | The EMBO Journal
François Maingret, Inger Lauritzen, Amanda Patel, Catherine Heurteaux, Roberto V. Reyes, Florian Lesage, Michel Lazdunski, Éric Honoré,
... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS ... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UPR ... J. Patel1, Catherine Heurteaux1, Roberto Reyes1, Florian Lesage1, Michel Lazdunski 1 and Eric Honoré1 1Institut de Pharmacologie Moléculaire ...
Tópico(s): Neurobiology and Insect Physiology Research
2000 - Springer Nature | The EMBO Journal
Christophe Chouabe, Nathalie Neyroud, Pascale Guicheney, Michel Lazdunski, Georges Romey, Jacques Barhanin,
... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, ... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, 660 ... Author Information Christophe Chouabe1, Nathalie Neyroud2, Pascale Guicheney2, Michel Lazdunski 1, Georges Romey1 and Jacques Barhanin1 1Institut de ...
Tópico(s): Cardiac Arrhythmias and Treatments
1997 - Springer Nature | The EMBO Journal
... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS – ... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS – UMR ... Girard1, Fabrice Duprat1, Florian Lesage1, Georges Romey1 and Michel Lazdunski 1 1Institut de Pharmacologie Moléculaire et Cellulaire, CNRS – ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2003 - Springer Nature | The EMBO Journal
... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, ... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, 660 ... by this author Author Information Amanda J. Patel1, Michel Lazdunski 1 and Eric Honoré1 1Institut de Pharmacologie Moléculaire ...
Tópico(s): Cardiac Ischemia and Reperfusion
1997 - Springer Nature | The EMBO Journal
... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS— ... Search for more papers by this author Michel Lazdunski Corresponding Author Michel Lazdunski Institut de Pharmacologie Moléculaire et Cellulaire, CNRS—UMR ... Christophe Girard1, Norbert Tinel1, Cécile Terrenoire1, Georges Romey1, Michel Lazdunski 1 and Marc Borsotto1 1Institut de Pharmacologie Moléculaire ...
Tópico(s): Immune Response and Inflammation
2002 - Springer Nature | The EMBO Journal
Amanda Patel, Michel Lazdunski, Éric Honoré,
... Valbonne, FranceSearch for more papers by this authorMICHEL LAZDUNSKI, Corresponding Author MICHEL LAZDUNSKI Pharmacologie Moléculaire et Cellulaire, CNRS, 660 route ... Valbonne, FranceSearch for more papers by this authorMICHEL LAZDUNSKI, Corresponding Author MICHEL LAZDUNSKI Pharmacologie Moléculaire et Cellulaire, CNRS, 660 route des ...
Tópico(s): Fuel Cells and Related Materials
1999 - Wiley | Annals of the New York Academy of Sciences
Claude Lazdunski, Michel Lazdunski,
For the Zn 2+ ‐phosphatase, the ratio k 3 / k 2 (pH 8.4) of the dephosphorylation ( k 3 ) and phosphorylation ( k 2 ) rates is very similar, about 1.4–1.7, for substrates which are very different chemically such as p ‐nitrophenyl phosphate, β‐glycerophosphate, 5′‐AMP and ATP. This means that k 2 is nearly the same for all these substrates. On the other hand with o ‐carboxyphenyl phosphate, phosphorylation is the determining step. The Co 2+ ‐enzyme has a much lower specific activity than the Zn 2+ ‐phosphatase. ...
Tópico(s): Enzyme function and inhibition
1969 - Wiley | European Journal of Biochemistry
Claude Lazdunski, Michel Lazdunski,
Purification, kinetic and structural properties of the alkaline isophosphatases of Escherichia coli The alkaline phosphatase of Escherichia coli (orthophosphoric monoester phosphohydrolase, EC 3.1.3.1) is heterogeneous on disc and starch-gel electrophoresis. Three isophosphatases were separated on a DEAE-cellulose column. These isozymes, which are formed in vivo, are dimers, two of them AA and BB are composed of two identical subunits, the third AB is a hybrid containing one monomer of each type. ...
Tópico(s): Erythrocyte Function and Pathophysiology
1967 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Claude Lazdunski, Michel Lazdunski,
In order to explain the mechanism of the catalytic action of the alkaline phosphatase (orthophosphoric monoester phosphohydrolase, EC 3.1.3.1) from Escherichia coli it is necessary to consider 3 different ionization states for the active center. The pK’s of the ionizations EH2⇄EH + H+ and EH⇄E + H+ are 7.1 and 8.6, respectively. The substrate is bound only to EH. Only the basic group (pK 7.1) participates in the phosphorylation and dephosphorylation of the active serine; phosphorylation of the serine ...
Tópico(s): Folate and B Vitamins Research
1966 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Claude Desnuelle, Jean‐François Renaud, E Delpont, G Serratrice, Renaud Delpont Lazdunski, Michel Lazdunski,
Abstract Properties of nitrendipine receptors have been analyzed in skeletal muscle from normal young boys and boys with Duchenne muscular dystrophy (DMD). The dissociation constant ( K d ) of the complex formed by nitrendipine with its specific receptors was 0.5 ± 0.1 n M in dystrophic muscle and 0.4 ± 0.1 n M in normal muscle. Maximum binding capacities B max were 403 ± 80 and 460 ± 60 fmol/mg protein in DMD and normal muscle, respectively. These results suggest that nitrendipine binding sites on nitrendipine‐ ...
Tópico(s): Neuroscience and Neural Engineering
1986 - Wiley | Muscle & Nerve
Frédéric H. Login, Vladimir E. Shevchik,
... 4011Crossref PubMed Google Scholar, 16Robert V. Hayes F. Lazdunski A. Michel G.P. J. Bacteriol. 2002; 184: 1779-1782Crossref ...
Tópico(s): Bacteriophages and microbial interactions
2006 - Elsevier BV | Journal of Biological Chemistry
Pascal Barbry, Olivier Chassande, Robert Marsault, Michel Lazdunski, Christian Frelin,
... and functional reconstitutionPascal Barbry, Olivier Chassande, Robert Marsault, Michel Lazdunski, and Christian FrelinCite this: Biochemistry 1990, 29, 4, ...
Tópico(s): Neuroscience and Neuropharmacology Research
1990 - American Chemical Society | Biochemistry
Hugues Schweitz, Jean Noel Bidard, Christian Frelin, David Pauron, Henk P.M. Vijverberg, Dureid M. Mahasneh, Michel Lazdunski, Francis Vilbois, Akira Tsugita,
... Pauron, Henk P. M. Vijverberg, Dureid M. Mahasneh, Michel Lazdunski, Francis Vilbois, and Akira TsugitaCite this: Biochemistry 1985, ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
1985 - American Chemical Society | Biochemistry
Sébastien Nicolas, Claude Zoukimian, Frank Bosmans, Jérôme Montnach, Sylvie Diochot, Eva Cuypers, Stéphan De Waard, Rémy Beroud, Dietrich Mebs, David J. Craik, Didier Boturyn, Michel Lazdunski, Jan Tytgat, Michel De Waard,
Phlotoxin-1 (PhlTx1) is a peptide previously identified in tarantula venom (Phlogius species) that belongs to the inhibitory cysteine-knot (ICK) toxin family. Like many ICK-based spider toxins, the synthesis of PhlTx1 appears particularly challenging, mostly for obtaining appropriate folding and concomitant suitable disulfide bridge formation. Herein, we describe a procedure for the chemical synthesis and the directed sequential disulfide bridge formation of PhlTx1 that allows for a straightforward ...
Tópico(s): Venomous Animal Envenomation and Studies
2019 - Multidisciplinary Digital Publishing Institute | Toxins
Tiffany L. Leighton, Daniel H. Yong, P. Lynne Howell, Lori L. Burrows,
... 3135Crossref PubMed Google Scholar, 33Robert V. Hayes F. Lazdunski A. Michel G.P. Identification of XcpZ domains required for ...
Tópico(s): Bacterial Genetics and Biotechnology
2016 - Elsevier BV | Journal of Biological Chemistry