Mathilde Leclère, Michel Desnoyers, Guy Beauchamp, Jean‐Pierre Lavoie,
Mast cells normally are present in equine bronchoalveolar lavage fluid (BALF), but usually represent <2% of all cells in healthy horses. An increased percentage of mast cells has been associated with airway hyperactivity and inflammatory airway diseases, but marked differences are reported between studies in normal and diseased horses. Because an abnormal mast cell count may be of clinical relevance, we compared the ability of a fast Romanowsky method to stain mast cell granules with that of 3 metachromatic ...
Tópico(s): Veterinary Equine Medical Research
2006 - Wiley | Journal of Veterinary Internal Medicine
Mathilde Leclère, Michel Desnoyers, Guy Beauchamp, Jean‐Pierre Lavoie,
Mast cells normally are present in equine bronchoalveolar lavage fluid (BALF), but usually represent <2% of all cells in healthy horses. An increased percentage of mast cells has been associated with airway hyperactivity and inflammatory airway diseases, but marked differences are reported between studies in normal and diseased horses. Because an abnormal mast cell count may be of clinical relevance, we compared the ability of a fast Romanowsky method to stain mast cell granules with that of 3 metachromatic ...
Tópico(s): Allergic Rhinitis and Sensitization
2006 - Wiley | Journal of Veterinary Internal Medicine
Sarah Guiziou, Federico Ulliana, Violaine Moreau, Michel Leclère, J. Bonnet,
Tools to systematically reprogram cellular behavior are crucial to address pressing challenges in manufacturing, environment, or healthcare. Recombinases can very efficiently encode Boolean and history-dependent logic in many species, yet current designs are performed on a case-by-case basis, limiting their scalability and requiring time-consuming optimization. Here we present an automated workflow for designing recombinase logic devices executing Boolean functions. Our theoretical framework uses ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2018 - American Chemical Society | ACS Synthetic Biology
Jean-François Baget, Michel Leclère, Marie-Laure Mugnier, Swan Rocher, Clément Sipieter,
This paper presents Graal, a java toolkit dedicated to ontological query answering in the framework of existential rules. We consider knowledge bases composed of data and an ontology expressed by existential rules. The main features of Graal are the following: a basic layer that provides generic interfaces to store and query various kinds of data, forward chaining and query rewriting algorithms, structural analysis of decidability properties of a rule set, a textual format and its parser, and import ...
Tópico(s): Service-Oriented Architecture and Web Services
2015 - Springer Science+Business Media | Lecture notes in computer science
Mélanie König, Michel Leclère, Marie-Laure Mugnier, Michaël Thomazo,
We address the issue of Ontology-Based Data Access, with ontologies represented in the framework of existential rules, also known as Datalog±. A well-known approach involves rewriting the query using ontological knowledge. We focus here on the basic rewriting technique which consists of rewriting t he initial query into a union of conjunctive queries. First, we study a generic breadth-first rewriting algorithm, which takes any rewriting operator as a parameter, and define properties of rewriting ...
Tópico(s): Data Management and Algorithms
2015 - IOS Press | Semantic Web
Mélanie König, Michel Leclère, Marie-Laure Mugnier, Michaël Thomazo,
We address the issue of Ontology-Based Data Access, with ontologies represented in the framework of existential rules, also known as Datalog+/-. A well-known approach involves rewriting the query using ontological knowledge. We focus here on the basic rewriting technique which consists of rewriting a conjunctive query (CQ) into a union of CQs. We assume that the set of rules is a finite unification set, i.e., for any CQ, there exists a finite sound and complete rewriting of this CQ with the rules. ...
Tópico(s): Biomedical Text Mining and Ontologies
2013 - Springer Science+Business Media | Lecture notes in computer science
Mélanie König, Michel Leclère, Marie-Laure Mugnier, Michaël Thomazo,
We address the issue of Ontology-Based Data Access which consists of exploiting the semantics expressed in ontologies while querying data. Ontologies are represented in the framework of existential rules, also known as Datalog+/-. We focus on the backward chaining paradigm, which involves rewriting the query (assumed to be a conjunctive query, CQ) into a set of CQs (seen as a union of CQs). The proposed algorithm accepts any set of existential rules as input and stops for so-called finite unification ...
Tópico(s): Data Management and Algorithms
2012 - Springer Science+Business Media | Lecture notes in computer science
Jean-François Baget, Michel Leclère, Marie-Laure Mugnier, Êric Salvat,
We consider positive rules in which the conclusion may contain existentially quantified variables, which makes reasoning tasks (such as conjunctive query answering or entailment) undecidable. These rules, called ∀∃-rules, have the same logical form as tuple-generating dependencies in databases and as conceptual graph rules. The aim of this paper is to provide a clearer picture of the frontier between decidability and non-decidability of reasoning with these rules. Previous known decidable classes were ...
Tópico(s): Advanced Database Systems and Queries
2011 - Elsevier BV | Artificial Intelligence
Jean-François Baget, Madalina Croitoru, Alain Gutierrez, Michel Leclère, Marie-Laure Mugnier,
Though similarities between the Semantic Web language RDF(S) and languages of the Conceptual Graphs family have often been pointed out, the differences between these formalisms have been a source of difficulties while trying to translate objets of a language into the other. In this paper, we present two such transformations, that have been implemented into the CoGUI platform, and discuss their respective strengths and weaknesses.
Tópico(s): Constraint Satisfaction and Optimization
2010 - Springer Science+Business Media | Lecture notes in computer science
Jean-François Baget, Olivier Corby, Rose Dieng-Kuntz, Catherine Faron Zucker, Fabien Gandon, Alain Giboin, Alain Gutierrez, Michel Leclère, Marie-Laure Mugnier, Rallou Thomopoulos,
Griwes is an initiative to develop a common model and an open-source freeware platform shared by different graph-based frameworks. We provide an overview of its objectives, architecture and specifications. We detail some of the basic mathematical structures that are used to characterize the primitives for graph-based knowledge representation. We then propose to factorize recurrent knowledge representation primitives that can be shared across specific graph-based languages and we provide a proof ...
Tópico(s): Advanced Database Systems and Queries
2008 - Springer Science+Business Media | Lecture notes in computer science
Michel Leclère, Marie-Laure Mugnier,
Query containment is a fundamental problem of databases. Given two queries q 1 and q 2, it asks whether the set of answers to q 1 is included in the set of answers to q 2 for any database. In this paper, we investigate this problem for conjunctive queries with negated subgoals. We use graph homomorphism as the core notion, which leads us to extend the results presented in [Ull97] and [WL03]. First, we exhibit sufficient (but not necessary) conditions for query containment based on special subgraphs ...
Tópico(s): Algorithms and Data Compression
2006 - Springer Science+Business Media | Lecture notes in computer science
Marie-Laure Mugnier, Michel Leclère,
Tópico(s): Constraint Satisfaction and Optimization
2006 - Elsevier BV | Data & Knowledge Engineering
Francky Trichet, Michel Leclère,
Tópico(s): Competency Development and Evaluation
2003 - Springer Science+Business Media | Lecture notes in computer science
Manuel Atencia, Michel Chein, Madalina Croitoru, D. Jérôme, Michel Leclère, Nathalie Pernelle, Fatiha Saïs, François Scharffe, Danai Symeonidou,
Many techniques were recently proposed to automate the linkage of RDF datasets. Predicate selection is the step of the linkage process that consists in selecting the smallest set of relevant predicates needed to enable instance comparison. We call keys this set of predicates that is analogous to the notion of keys in relational databases. We explain formally the different assumptions behind two existing key semantics. We then evaluate experimentally the keys by studying how discovered keys could ...
Tópico(s): Service-Oriented Architecture and Web Services
2014 - Springer Science+Business Media | Lecture notes in computer science
... S., Herold G., Huang X., Humphreys W. M., Leclère Q., Malgoezar A., Michel U., Padois T., Pereira A., Picard C., Sarradj ...
Tópico(s): Speech and Audio Processing
2022 - American Institute of Aeronautics and Astronautics | AIAA Journal
Tópico(s): Constraint Satisfaction and Optimization
1997 - Springer Science+Business Media | Lecture notes in computer science
Olivier Carloni, Michel Leclère, Marie-Laure Mugnier,
This paper is devoted to an industrial case study focused on the issue of how to enhance an existing knowledge management tool (ITM) with reasoning capabilities, by introducing a semantic query mechanism as well as validation and inference services. ITM knowledge representation language is based on topic maps. We show that these topic maps (and especially those describing the domain ontology and annotation base) can be naturally mapped to the $\mathcal {SG}$ family, a sublanguage of conceptual graphs. ...
Tópico(s): Service-Oriented Architecture and Web Services
2007 - Springer Science+Business Media | Applied Intelligence
Pascal Viville, Philippe Leclère, Alain Deffieux, Michel Schappacher, Julien Bernard, Rédouane Borsali, Jean‐Luc Brédas, Roberto Lazzaroni,
This work deals with the study of comb-like vs. arborescent grafted copolymers made of poly(chloroethyl vinyl ether)-g-polystyrene (PCEVE-g-PS). We describe how the molecular architecture of the branched polymers affects their nanoscale organization in thin films, as observed using atomic force microscopy. The results indicate that modifying the molecular architecture from a ‘generation-zero’ comb-like (PCEVE-g-PS) to a ‘first-generation’ hyperbranched (PCEVE-g-(PS-b-PCEVE-g-PS)) architecture strongly ...
Tópico(s): Force Microscopy Techniques and Applications
2004 - Elsevier BV | Polymer
Suzanne Lesage, Laurence Leclere, Ebba Lohmann, Michel Borg, Merle Ruberg, Alexandra Dürr, Alexis Brice,
<i>Background:</i> Mutations in the <i>LRRK2 </i>gene, the most frequent of which is the G2019S mutation in exon 41, cause familial and sporadic Parkinson’s disease (PD) with reduced penetrance. <i>Objectives:</i> To assess the frequency of the <i>LRRK2 </i>G2019S mutation in families thought to have autosomal recessive PD (siblings but not their parents were affected) and to determine the clinical features of <i>LRRK2</i> mutation carriers. <i>Methods:</i> ...
Tópico(s): Ginkgo biloba and Cashew Applications
2007 - Karger Publishers | Neurodegenerative Diseases
Rémi Cousson, Quentin Leclère, Marie-Agnès Pallas, Michel Bérengier,
The issue of acoustic source identification has been widely explored in static or quasi-static source contexts, more recently for moving sources, in a wide range of applications. In the case of a passing-by vehicle, the beamforming method is a reference having well-known limitations that deconvolution methods try to overcome. Mostly developed in static source situations at the beginning, some recent deconvolution extensions to moving sources have been proposed in the transportation field, mainly ...
Tópico(s): Acoustic Wave Phenomena Research
2018 - Elsevier BV | Journal of Sound and Vibration
Karine Hestroffer, R. Mata, D Camacho, C. Leclère, G. Tourbot, Yann-Michel Niquet, A. Cros, Catherine Bougerol, H. Renevier, B. Daudin,
The growth and structural properties of GaN/AlN core-shell nanowire heterostructures have been studied using a combination of resonant x-ray diffraction, Raman spectroscopy and high resolution transmission electron microscopy experiments. For a GaN core of 20 nm diameter on average surrounded by a homogeneous AlN shell, the built-in strain in GaN is found to agree with theoretical calculations performed using a valence force field model. It is then concluded that for an AlN thickness up to at least ...
Tópico(s): ZnO doping and properties
2010 - IOP Publishing | Nanotechnology
Michel Leclère, Marie-Laure Mugnier,
Tópico(s): Natural Language Processing Techniques
2006 - Springer Science+Business Media | Lecture notes in computer science
Adéla Chahine, Alexis Chenouard, Nicolas Joram, Lionel Berthomieu, Geneviève Du Pont‐Thibodeau, Brice Leclère, Jean‐Michel Liet, Pierre Maminirina, Laurène Leclair‐Visonneau, Sophie Breinig, Pierre Bourgoin,
Early prognostication of neurologic outcome in neonates and children supported with extra-corporeal membrane oxygenation (ECMO) is challenging. Amplitude-integrated EEG (aEEG) offers the advantages of continuous monitoring and 24-hours availability at the bedside for intensive care unit providers. The objective of this study was to describe the early electrophysiological background patterns of neonates and children undergoing ECMO and their association with neurologic outcomes.This was a retrospective ...
Tópico(s): Mechanical Circulatory Support Devices
2021 - Lippincott Williams & Wilkins | Journal of Clinical Neurophysiology
Franck Marie Leclère, Michel Germain, Gregory A. Lewbart, Frank Unglaub, Serge Mordon, Dominique Louis,
The use of an operating microscope in animal liver surgery has made it possible to obtain new experimental models. The goal of this prospective animal study is to present our experience with dogfish portocaval microanastomoses.Nineteen portocaval microanastomoses were performed in dogfish. The end-to-side anastomoses were accomplished using continuous 11-0 sutures. The diameter of the vessels and time required for the anastomoses were measured. A patency test and its outcome were also prospectively ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2011 - Elsevier BV | Clinics and Research in Hepatology and Gastroenterology
Stéphane Culine, Catherine Lhommé, Guy Michel, J. Leclère, Pierre Duvillard, Jean-Pierre Droz,
The last two decades have seen great improvements in the management of patients with germ-cell tumors of the ovary. The initial treatment approach includes conservative surgery and cisplatin-based chemotherapy in most cases. At completion of chemotherapy, the role of second-look surgery remains questionable. We retrospectively analyzed the long-term outcome (median follow-up, 8 years) of 40 patients who received various chemotherapy regimens after primary surgery and focused on the role of second- ...
Tópico(s): Gestational Trophoblastic Disease Studies
1996 - Wiley | Journal of Surgical Oncology
Roberto Merino-Martínez, Pieter Sijtsma, Mirjam Snellen, Thomas Ahlefeldt, Jérôme Antoni, Christopher J. Bahr, Daniel Blacodon, Daniel Ernst, A. Finez, Stefan Funke, Thomas Geyer, Stefan Haxter, Gert Herold, Xun Huang, William M. Humphreys, Quentin Leclère, A.M.N. Malgoezar, U. Michel, Thomas Padois, Antonio Pereira, Christophe Picard, Ennes Sarradj, Henri Siller, Dick G. Simons, Carsten Spehr,
Phased microphone arrays have become a well-established tool for performing aeroacoustic measurements in wind tunnels (both open-jet and closed-section), flying aircraft, and engine test beds. This paper provides a review of the most well-known and state-of-the-art acoustic imaging methods and recommendations on when to use them. Several exemplary results showing the performance of most methods in aeroacoustic applications are included. This manuscript provides a general introduction to aeroacoustic ...
Tópico(s): Hydrology and Sediment Transport Processes
2019 - Springer Science+Business Media | CEAS Aeronautical Journal
Mélody Leclère, Laurent Bernard, Sébastien Livi, Michel Bardet, Armel Guillermo, Lionel Picard, Jannick Duchet‐Rumeau,
In this work, new gelled electrolytes were prepared based on a mixture containing phosphonium ionic liquid (IL) composed of trihexyl(tetradecyl)phosphonium cation combined with bis(trifluoromethane)sulfonimide [TFSI] counter anions and lithium salt, confined in a host network made from an epoxy prepolymer and amine hardener. We have demonstrated that the addition of electrolyte plays a key role on the kinetics of polymerization but also on the final properties of epoxy networks, especially thermal, ...
Tópico(s): Ionic liquids properties and applications
2018 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Rami Moucari, Michelle Martinot-Peignoux, Vincent Mackiewicz, Nathalie Boyer, Marie–Pierre Ripault, Corinne Castelnau, Laurence Leclere, Agnès Dauvergne, Dominique Valla, Michel Vidaud, Marie-Hélène Nicolas-Chanoine, Patrick Marcellin,
The aim of this study was to assess the influence of hepatitis B virus (HBV) genotypes on serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative patients treated with pegylated interferon-alpha2a (PEG-IFN-alpha2a).A total of 48 consecutive patients treated with PEG-IFN-alpha2a (180 microg/week) for 48 weeks were assessed. HBV genotype was determined. Serum HBV DNA and HBsAg were assessed at baseline, during treatment (weeks 12, 24 and 48) and during follow-up (weeks ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2009 - SAGE Publishing | Antiviral Therapy
D. Élias, Thierry de Baère, Ann Roche, Michel Ducreux, J. Leclère, P Lasser,
Abstract Background The relative growth rates of human liver metastases are not known. The aim of this study was to determine in humans the growth rate of liver parenchyma during regeneration and the growth rate of liver metastases during the same process. Methods Among 556 patients hepatectomized for a malignant lesion, 48 underwent preoperative selective right portal vein embolization to induce hypertrophy of the left lobe. Five cases were selected because a liver metastasis was present inside ...
Tópico(s): Organ Transplantation Techniques and Outcomes
1999 - Oxford University Press | British journal of surgery
Olivier Carloni, Michel Leclère, Marie-Laure Mugnier,
This paper is devoted to an industrial case study focused on the issue of how to enhance ITM, a knowledge management tool, with reasoning capabilities, primarily by introducing a semantic query mechanism. ITM knowledge representation language is based on topic maps. We show that these topic maps (and especially those describing the domain ontology and the annotation base) can be naturally mapped to the SG family, a sublanguage of conceptual graphs. As this mapping is reversible, ITM can be equipped ...
Tópico(s): Advanced Database Systems and Queries
2006 - Springer Science+Business Media | Lecture notes in computer science