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Artigo Acesso aberto Revisado por pares

Lila Bouadma, François Barbier, Lucie Biard, Marina Esposito‐Farèse, Bertrand Le Corre, A. Macrez, Laurence Salomon, Christine Bonnal, C. Zanker, Christophe Najem, Bruno Mourvillier, Jean Christophe Lucet, B. Régnier, Michel Wolff, Florence Tubach,

Background Influenza-vaccination rates among healthcare workers (HCW) remain low worldwide, even during the 2009 A(H1N1) pandemic. In France, this vaccination is free but administered on a voluntary basis. We investigated the factors influencing HCW influenza vaccination. Methods In June–July 2010, HCW from wards of five French hospitals completed a cross-sectional survey. A multifaceted campaign aimed at improving vaccination coverage in this hospital group was conducted before and during the 2009 ...

Tópico(s): Travel-related health issues

2012 - Public Library of Science | PLoS ONE

Artigo Revisado por pares

Karim Lakhal, Stéphan Ehrmann, Anis Chaari, Jean‐Pierre Laissy, B. Régnier, Michel Wolff, Olivier Pajot,

Contrast-induced nephropathy (CIN) has been extensively studied in the ward but only scarcely in intensive care unit (ICU) patients, even if they may be particularly prone to develop or to worsen acute kidney insufficiency. We aimed to measure the incidence of CIN in a large ICU population using the Acute Kidney Injury Network (AKIN) definition and to investigate its impact on patients' outcome.In this 3-year retrospective study, we included all patients undergoing, during their stay in our medical ...

Tópico(s): Trauma, Hemostasis, Coagulopathy, Resuscitation

2011 - Elsevier BV | Journal of Critical Care

Artigo Acesso aberto Revisado por pares

Lila Bouadma, Bruno Mourvillier, Véronique Deiler, Nelly Derennes, Bertrand Le Corre, Isabelle Lolom, B. Régnier, Michel Wolff, Jean‐Christophe Lucet,

Prevention of ventilator-associated pneumonia (VAP) requires a complex approach that should include factors affecting healthcare workers' (HCWs) behavior. This study attempted to assess change of individual factors throughout a multifaceted program focusing on VAP prevention.The prevention program involved all HCWs in a 20-bed medical intensive care unit (ICU) and included a multidisciplinary task force, an educational session, direct observations and performance feedback, technical improvements, and ...

Tópico(s): Infection Control in Healthcare

2010 - Springer Science+Business Media | Intensive Care Medicine

Artigo Revisado por pares

Marc Auburtin, Raphaël Porcher, Fabrice Bruneel, A. Scanvic, J. Trouillet, Jean Pierre P. Bedos, B. Régnier, Michel Wolff,

We have undertaken this retrospective study to determine factors associated with in-hospital mortality and morbidity in 80 adult patients with severe Streptococcus pneumoniae meningitis. Clinical characteristics at admission of patients infected with susceptible (n = 54) and nonsusceptible (n = 17) strains to penicillin G were similar: age: 51 ± 19 versus 58 ± 15 yr (p = 0.16); Simplified Acute Severity Score (SAPS II): 39 ± 14 versus 41 ± 11 (p = 0.68); and Glasgow Coma Score: 8 ± 3 versus 9.5 ± 3 (p = 0.21), respectively. ...

Tópico(s): Respiratory viral infections research

2002 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine

Artigo Acesso aberto Revisado por pares

O. Rohmer, Étienne Bertrand, Diego Mercerat, Julie Régnier, Michel Pernoud, Philippe Langlaude, M. Alvarez,

In seismic hazard studies, site effects assessment is based on an accurate knowledge of mechanical properties and geometry of superficial geological formations. The Lower Var Valley (Nice, southeastern France) is a 2 km wide fluvial sedimentary basin where site effects have been observed on earthquake recordings. In addition, this area is a significant economically developing zone including the second largest airport of France. Therefore, it is highly important to define a 3D sub-surface model of ...

Tópico(s): Seismic Imaging and Inversion Techniques

2020 - Elsevier BV | Engineering Geology

Artigo Revisado por pares

Lila Bouadma, Bruno Mourvillier, Véronique Deiler, Bertrand Le Corre, Isabelle Lolom, B. Régnier, Michel Wolff, Jean‐Christophe Lucet,

To determine the effect of a 2-yr multifaceted program aimed at preventing ventilator-acquired pneumonia on compliance with eight targeted preventive measures.Pre- and postintervention observational study.A 20-bed medical intensive care unit in a teaching hospital.A total of 1649 ventilator-days were observed.The program involved all healthcare workers and included a multidisciplinary task force, an educational session, direct observations with performance feedback, technical improvements, and reminders. ...

Tópico(s): Respiratory Support and Mechanisms

2010 - Lippincott Williams & Wilkins | Critical Care Medicine

Artigo Revisado por pares

Sébastian Pease, Lila Bouadma, Nathalie Kermarrec, Frédérique Schortgen, B. Régnier, Michel Wolff,

Tópico(s): Thermal Regulation in Medicine

2009 - Springer Science+Business Media | Intensive Care Medicine

Artigo Revisado por pares

A-S Michallet, Julia Tonini, Jean-Claude Régnier, Michel Guinot, A. Favre‐Juvin, Véronique‐Aurélie Bricout, S. Halimi, Bernard Wuyam, Patrice Flore,

Indirect calorimetry during exercise provides two metabolic indices of substrate oxidation balance: the crossover point (COP) and maximum fat oxidation rate (LIPOXmax). We aimed to study the effects of the analytical device, protocol type and ventilatory response on variability of these indices, and the relationship with lactate and ventilation thresholds.After maximum exercise testing, 14 relatively fit subjects (aged 32+/-10 years; nine men, five women) performed three submaximum graded tests: one ...

Tópico(s): Diet and metabolism studies

2008 - Elsevier BV | Diabetes & Metabolism

Artigo Acesso aberto Revisado por pares

Lila Bouadma, Frédérique Schortgen, R. Thomas, S. Wutke, François Lellouche, B. Régnier, Michel Wolff,

The characteristics of spontaneous aerobic Gram-negative bacillary meningitis (AGNBM) were determined in 40 adults requiring admission to an intensive care unit (ICU) during a 16-year period in ten French ICUs. Eight infections were hospital-acquired and most patients had predisposing factors, mainly chronic alcoholism and an immunocompromised status. Three immunosuppressed patients had disseminated strongyloidiasis. Gram's stain, cerebrospinal fluid and blood cultures were positive for 85%, 98% and ...

Tópico(s): Infective Endocarditis Diagnosis and Management

2006 - Elsevier BV | Clinical Microbiology and Infection

Artigo Revisado por pares

Martial Thyrault, Bertrand Gachot, Claude Chastang, Bertrand Souweine, Jean‐François Timsit, J. P. Bédos, B. Régnier, Michel Wolff,

Tópico(s): Pharmacological Effects and Toxicity Studies

1997 - Springer Science+Business Media | Intensive Care Medicine

Revisão

C Darras-Joly, Benoît Veber, Jean‐Pierre Bédos, Bertrand Gachot, B. Régnier, Michel Wolff,

Cerebral aspergillosis carries a mortality rate close to 100%, especially in immunocompromised patients. We describe 3 patients who contracted cerebral aspergillosis after neurosurgery, 2 of whom survived after exhaustive surgical treatment and medical treatment with high doses of amphotericin B (once liposomal), 5-fluorocytosine and itraconazole. We review the few non-fatal cases of cerebral aspergillosis reported. We consider that surgical excision must be complete and repeated if necessary, always ...

Tópico(s): Infectious Diseases and Mycology

1996 - Informa | Scandinavian Journal of Infectious Diseases

Artigo Revisado por pares

M Régnier, Michel Daemon,

Human keratinocytes grown on deepidermized dermis (DED) are able to reconstruct a morphologically normal stratified and keratinized epidermis. This culture system is suitable for studying in vitro the effects of various hormones and factors on epidermal differentiation, and the goal of the present work was to study the effect of vitamin D. We found that the hormonal form of vitamin D3, 1,25-dihydroxyvitamin D3, produced very specific alterations in epidermal architecture in a dose-dependent manner, ...

Tópico(s): Skin and Cellular Biology Research

1991 - Elsevier BV | Differentiation

Artigo

M Régnier, Michel Darmon,

Tópico(s): Plant tissue culture and regeneration

1989 - Springer Nature | In Vitro Cellular & Developmental Biology

Artigo Revisado por pares

É. Rouveix, A Buré, B. Régnier, Michel Wolff, B. Pangon, MARIE JOSEPH LAISNE, François Vachon,

Twenty-two patients admitted to the ICU with a severe nosocomial infection caused by multi-resistant Gram-negative bacilli were treated with imipenem combined with cilastatin. We treated nine cases of meningo-ventriculitis, eight cases of septicaemia, four cases of mediastinitis, and one case of pneumonia. The bacteria responsible were Acinetobacter spp. (10), Pseudomonas aeruginosa (5), Enterobacter cloacae (5), Klebsiella pneumoniae (3), Proteus spp. (2), Streptococcus spp. (2), Serratia marcescens ( ...

Tópico(s): Pneumonia and Respiratory Infections

1986 - Oxford University Press | Journal of Antimicrobial Chemotherapy

Artigo Acesso aberto Revisado por pares

Minh-Tan Pham, Grégoire Mercier, Olivier Regniers, Julien Michel,

In this article, we develop a novel method for the detection of vineyard parcels in agricultural landscapes based on very high resolution (VHR) optical remote sensing images. Our objective is to perform texture-based image retrieval and supervised classification algorithms. To do that, the local textural and structural features inside each image are taken into account to measure its similarity to other images. In fact, VHR images usually involve a variety of local textures and structures that may ...

Tópico(s): Remote-Sensing Image Classification

2016 - Multidisciplinary Digital Publishing Institute | Remote Sensing

Artigo Revisado por pares

D. Rouland, A. Cisternas, R. Denkmann, H. Dufumier, Marc Régnier, Michel Lardy,

Abstract A seismic swarm which occurred in December 1994 near the Aoba volcano, Vanuatu, is investigated in detail by analyzing local and regional broad band seismic records. The seismic area is situated in a poorly instrumented region, although major seismic and volcanic events are possible. The data collected by four permanent short period stations (the nearest one being installed in the Espiritu Santo Island located 80 km from the volcano) allowed us to locate epicenters with a 2–3 km precision, ...

Tópico(s): Geological and Geochemical Analysis

2001 - Elsevier BV | Tectonophysics

Artigo Acesso aberto Revisado por pares

Esther Regnier, Michel De Lara,

The World Summit on Sustainable Development (Johannesburg, 2002) encouraged the adoption of an ecosystem approach. In this perspective, we propose a theoretical management framework that deals jointly with three issues: (i) ecosystem dynamics, (ii) conflicting issues of production and preservation, and (iii) robustness with respect to dynamics uncertainties. We consider a discrete-time two-species dynamic model, where states are biomasses and where two controls act as harvesting efforts of each species. ...

Tópico(s): Economic theories and models

2015 - Springer Science+Business Media | Environmental Modeling & Assessment

Artigo Acesso aberto Revisado por pares

Julie Régnier, Clotaire Michel, Étienne Bertrand, Philippe Guéguen,

Following the Mw 7.3 Martinique earthquake, November 29th, 2007, a post-seismic survey was conducted by the Bureau Central Sismologique Français (BCSF) for macroseismic intensities assessment. In addition to the inventories, ambient vibration recordings were performed close to the particularly damaged zones in the free-field and the buildings. The objective of the paper is to show the relevancy of performing ambient vibration recordings for post-earthquake surveys. The analyses of the recordings ...

Tópico(s): Seismic Waves and Analysis

2013 - Elsevier BV | Soil Dynamics and Earthquake Engineering

Artigo

Thierry Abribat, Alain Régnier, Michel Morre,

Summary The growth hormone (GH) secretory response to varying doses (1, 5 and 25μg/kg) of intravenous (i.v.) human GH releasing factor (GRF) (1–44) was measured in four, 16‐month‐old female dogs and compared to the GH response to placebo (vehicle solubilizing GRF) and standard Clonidine test (10μg/kg i.v.). The three doses of GRF had no apparent clinical side effects and were capable of eliciting a rapid increase in the mean plasma GH level. The rise in plasma GH occurred within 5 minutes with a peak response ...

Tópico(s): Veterinary Medicine and Surgery

1989 - Wiley | Journal of Veterinary Medicine Series A

Artigo

Romain Sonneville, Isabelle Klein, L. Bouadma, Bruno Mourvillier, B. Régnier, Michel Wolff,

Les complications neurologiques des endocardites infectieuses sont fréquentes et ont une importance particulière car elles sont souvent inaugurales, peuvent mettre en jeu le pronostic vital et modifier sensiblement la prise en charge. Elles doivent être recherchées devant tout signe neurologique focal ou trouble de conscience inexpliqué. Les accidents vasculaires ischémiques par embolie d’une végétation constituent la principale complication neurologique des endocardites. Ils sont plus fréquents ...

Tópico(s): Streptococcal Infections and Treatments

2009 - CIG Media Group | Réanimation

Artigo Revisado por pares

Fabien Koskas, Isabelle Brochériou, Philippe Cluzel, Jean-Dominique Singland, B Regnier, Michel Bonnot, Édouard Kieffer,

The purpose of this study was to evaluate the healing at 6 months of aortic stent-grafts custom-made by using Z stents and woven polyester in an animal model. Stent-grafts were built by a published method using autoexpandable stainless steel stents continuously compiled with polyester sutures and covered with a woven polyester membrane. Fourteen stent-grafts of 3 different designs were deployed under fluoroscopic control into the thoracic and the abdominal aorta of 7 adult sheep. At 6 months, all ...

Tópico(s): Infectious Aortic and Vascular Conditions

2005 - SAGE Publishing | Vascular and Endovascular Surgery

Artigo Revisado por pares

Romain Sonneville, H. Ferrand, Florence Tubach, Carine Roy, Lila Bouadma, Isabelle Klein, Arnaud Foucrier, B. Régnier, Bruno Mourvillier, Michel Wolff,

Objective We aimed to investigate the prognosis of HIV-infected patients with acute neurological complications at the highly active antiretroviral therapy (HAART) era. Methods We performed a retrospective study in HIV-infected patients admitted to a medical ICU with neurological complications between 2001 and 2008. Results Among the 210 studied patients (median [interquartile range] CD4-cell count: 80 [18–254]/μL; HIV viral load: 4.8 [2–5.3] log10/mL), 40 (19%) had unknown HIV status at admission. Neurological ...

Tópico(s): Infectious Encephalopathies and Encephalitis

2011 - Elsevier BV | Journal of Infection

Artigo Acesso aberto Revisado por pares

Lila Bouadma, E. Deslandes, Isabelle Lolom, Bertrand Le Corre, Bruno Mourvillier, B. Régnier, Raphaël Porcher, Michel Wolff, Jean‐Christophe Lucet,

Ventilator-associated pneumonia (VAP), the most common hospital-acquired infection in intensive care units, increases mortality and health care costs. We describe the long-term impact of a multifaceted program for decreasing VAP rates that markedly improved compliance with 8 targeted preventive measures.We compared VAP rates during a 45-month baseline period and a 30-month intervention period in a cohort of patients who received mechanical ventilation for > 48 h. VAP was diagnosed on the basis of quantitative ...

Tópico(s): Healthcare Decision-Making and Restraints

2010 - Oxford University Press | Clinical Infectious Diseases

Artigo Revisado por pares

Édouard Ferrand, François Lemaire, B. Régnier, Khaldoun Kuteifan, Michel Badet, Pierre Asfar, Samir Jaber, Jean-Luc Chagnon, Anne Renault, R. Robert, Frédéric Pochard, Christian Hervé, Christian Brun‐Buisson, Philippe Duvaldestin,

Several studies have pointed out ethical shortcomings in the decision-making process for withholding or withdrawing life-supporting treatments. We conducted a study to evaluate the perceptions of all caregivers involved in this process in the intensive care unit. A closed-ended questionnaire was completed by 3,156 nursing staff members and 521 physicians from 133 French intensive care units (participation rate, 42%). Decision-making processes were perceived as satisfactory by 73% of physicians and ...

Tópico(s): Ethics in medical practice

2003 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine

Capítulo de livro Acesso aberto Revisado por pares

Jérôme Darmont, Christophe Fromantin, Stéphane Régnier, Le Gruenwald, Michel Schneider,

We present in this paper three dynamic clustering techniques for Object-Oriented Databases (OODBs). The first two, Dynamic, Statistical & Tunable Clustering (DSTC) and StatClust, exploit both comprehensive usage statistics and the inter-object reference graph. They are quite elaborate. However, they are also complex to implement and induce a high overhead. The third clustering technique, called Detection & Reclustering of Objects (DRO), is based on the same principles, but is much simpler to implement. ...

Tópico(s): Web Data Mining and Analysis

2001 - Springer Science+Business Media | Lecture notes in computer science

Artigo Revisado por pares

M Régnier, Pierre Vaigot, Michel Darmon, M Pruniéras,

Stratified epithelia such as epidermis are classically considered to comprise 2 cell compartments, one consisting of undifferentiated proliferative cells occupying the basal layer, and the other consisting of differentiated postmitotic cells occupying the suprabasal layers. It is also generally assumed that the 58K basic-50K acidic couple of keratins is expressed in basal cells, while the 67K basic-56K acidic couple appears in suprabasal cells. In the present work we demonstrate that the population ...

Tópico(s): Wnt/β-catenin signaling in development and cancer

1986 - Elsevier BV | Journal of Investigative Dermatology

Artigo Acesso aberto Revisado por pares

Sophie Versavaud, G. Régnier, Gwénaël Gouadec, Michel Vincent,

Microinjection-molded and compression-molded polyamide (PA12) matrix composites filled with 0.67, 1.33, 2 and 4 wt% multi-walled carbon nanotubes (MWNTs) were prepared from twin-screw extruded pellets. The compression molded samples have an electrical percolation threshold close to 1.2 wt%. Coupled rheological and electrical measurements show that their electrical properties start decreasing as soon as shear begins and are partially restored during flow, suggesting successively breakage and reconstruction ...

Tópico(s): Advanced Sensor and Energy Harvesting Materials

2014 - Elsevier BV | Polymer