Gráinne Gilmore, Robert Readman, Andrew Robson, Matt Dickinson Chief Sports Correspondent, Lucy Alexander, Amanda Andrews, Édouard Balladur, Jeremy Austin, John Gudgeon, Zahid Hussain, Simon Barnes, Sean O'Neill Security Editor, Ashling O'Connor Olympics Correspondent, Robert Lindsay, Marilyn Leary, James Rossiter Property Correspondent, Mark Souster, Alexandra Frean Education Editor, Michael Evans Defence Editor, Philip Howard, Patrick Hosking Business commentary, Carol Midgley, Dr Saul Berkovitz, Christine Seib, David Chater, Michael Binyon, James Bone, Murad Ahmed, Lorna Blackwood, Richard Hobson One-Day Cricket Correspondent, Elizabeth Judge, Dr Chris Hasford, Lucia Van Der Post, Carl Mortished, Will Pavia, James Hider, Kevin Eason, Geoff Brown, Joanna Sugden, Gerald Davies, Martin Samuel Chief Football Correspondent, Joe Joseph, Andrew Norfolk, Robin Pagnamenta, Dr Peter Greenhalgh, Mark Barrowcliffe, John Clarke, Jane MacArtney, Siobhan Kennedy, Francis Elliott, Gabby Logan, Dominic Walsh, Tom Bawden, C. M. Dawson, Sonia Wakely, Peter Chessman, Tim Reid, Ruth Gledhill Religion Correspondent, Dan Sabbagh, Richard Ford Home Correspondent, Anne Ashworth Property Editor, Alan Hamilton, Mark Ellen, Julian Thomas, Charles Bremner, Ben MacHell, Helen Rumbelow, Greg Hurst, Susan Thompson, Terry Ramsey, Derwent May, Paula Hawkins, Marjorie Wallace, Ed Potton, Oliver Kay, Gerard Baker, John Westerby, Sunder Katwala, Tom Baldwin, Diederik de Boorder, Pete Paphides, Ann Treneman, Jennifer Howze, Rob Wright, Edward Gorman Motor Racing Correspondent, Emma Pomfret, Neil Harman Tennis Correspondent, Raymond Keene, Luke Leitch, Adam Sage, Peter Riddell Political Briefing, Matt Hughes, Rebecca O'Connor, Robin Stemp, Simon Barnes Chief sports writer, Jeremy Page, Chris Campling, Bronwen Maddox, Adam Fresco Crime Correspondent, Patrick Hosking, Richard Owen, Lindsey Bareham, Malcolm Bowden, Damian Whitworth, Mick Hume, Roger Boyes, James Charles, Peter Dixon, Nick Hasell, Dalya Alberge, Owen Slot Chief Sports Reporter, Tony Cascarino, Paul Simons, Michael Herman, Steve Jelbert, Nick Szczepanik, Anne Ashworth, Philip Webster Political Editor, Sam Coates Chief Political Correspondent, Jane Shilling, Sophie Heawood, Brian Kennett, Angus MacLeod, Frank Greaney, Russell Jenkins, Ben MacIntyre, Lisa Kate Osofsky, Nick Clegg, Rajeev Syal, David Sanderson, David Sinclair, Kieran Falconer, Catherine Philp, Martin Waller, Chris Ayres, Lewis Smith Environment Reporter, Mark Loveday, Patrick Foster, Nigel Hawkes Health Editor, Benedict Nightingale, Stuart Birch, Paul Larter, Stephen Dalton, Nicola Woolcock, Leo Lewis, Bill Edgar, Frances Gibb, Richard Morrison, James Christopher, Tony Halpin, Michael Evans, Alan Lee Racing Correspondent, Olav Bjortomt, Miles Costello, Fiona Hamilton, Kasia MacIejowska, Neil Gaffney, Richard Ford, Carolyn Asome Deputy Fashion Editor, Elizabeth Judge Telecoms Correspondent, Charles Saumarez Smith Secretary and Chief Executive,
... running. Gerard Baker looks at their credentials AA Michelle Obama Cindy McCain Bill Clinton Timesonline War of the Wu … Can hip-hop's battling brothers kiss and ...
2008 - Gale Group | TDA
Gwennaëlle Versini, Itys Comet, Michelle Wu, Laura L. Mays Hoopes, Étienne Schwob, Philippe Pasero,
... France Search for more papers by this author Michelle Wu Michelle Wu Biology Department and Molecular Biology Program, Pomona College, ... France Search for more papers by this author Michelle Wu Michelle Wu Biology Department and Molecular Biology Program, Pomona College, ...
Tópico(s): Genetic Neurodegenerative Diseases
2003 - Springer Nature | The EMBO Journal
Giles Smith, Gráinne Gilmore, Janice Turner, Simon Burns, Cecilia Conrad, Faye White, Donald MacGillivray, SA, Andrew Pierce, Adam Sherwin Media Reporter, Sarah Potter, Dr Thomas Stuttaford and Suzi Godson, Jane MacQuitty, Simon Barnes, Richard Beeston and michael Theodoulou, Tim De Lisle, Philip Webster and David Rose, Paul Hoggart, Mark Souster, Anna Friel, Catherine Phlip, Richard Hobson, John Mulvey, Edward Owen and Daniel McGrory, Andrew Robinson, Emma Cook, Frankie Dettori, Philip Howard, Hannah Betts, Carol Midgley, Dan Frank, James Harkin, James Bone, James Ducker, Rachel Campbell-Johnston, Nic Hopkins, Julie Denton, Kate Reardon, Elizabeth Judge, Lucia Van Der Post, Declan Buckley, Wendy Ide, Roger Maynard, John Bungey, Kevin Eason, Barbara Trapido, Gerald Davies, Clare Stewart, Giles Coren, Andrew Norfolk, Lessley O'Toole, David Sharrock, Vivienne Parry, Mark Griffiths, Nancy Durrant, Anne Celin Jaeger, Brian Sleightholm (Chairman), John Clarke, Stephen McClarence, Ann Widdecombe, Jane MacArtney, Rob Cassy, Katherine Swift, Edward Green, Jack Malvern, Simon Thorpe, Tom Bawden, Dominic Walsh, James Doran Wall Street Correspondent, Ruth Gledhill, Debra Craine, Gary Jacob, Mike Pattenden, Allan Simmons, Norman Harris, Andrew Sear, Dr Jane Collins, Jane Clarke, John McNAMARA, Tom Gatti, Candida Crewe, Yvonne Roberts, Nick Robinson, Alan Hamilton, Stephen Farrell, Jo Morris, Dr. Copperfield, Nick Wyke, Natalie Curtis, Rhys Blakely, Gregor Milne, Roland Watson, Tina Gaudoin, David Hands, Tom Stuart-Smith, Martin Symington, Lucy Mayhew, Liz Chong, Genevieve Fox, Tim Teeman, Patience Wheatcroft Business Editor, Arwa Haider, Ivan Hewett, Richard Dawkins, Tom Petherick, Russell Kempson, Peter Paphides, David Rowan, Nigel Williamson, Tony Halpin Education Editor, Daniel McGrory, Gary Duncan Economics Editor, Richard Cork, Ed Potton, Stephen Anderton, Carola Long, Stevie Chick, David Lister, Mark Atherton, Jane Wheatley, Neil Harman, Lisa Armstrong, Rick Broadbent, Sarah Vine, Philip Wilson-Sharp, Jill Sherman Whitehall Editor, Sam Coates, Mark Henderson Science Correspondent, Chris Power, Dr Feelgood, Neel Mukherjee, John Hopkins Golf Correspondent, Rob Wright, Geoffrey Dean, Patrick Cockburn, Magnus Grimond, Michael M. Dent, Victoria O'Brien, Gavin Martin, Alexandra Frean and David Charter, Tony Evans, Raymond Keene, Malcolm Johnson, Suzi Godson, Matthew Pryor, Marco Pierre White, Matt Dickinson, Rebecca O'Connor, Gordon Ramsay, Tom McIntyre, Christine Buckley Industrial Editor, Kaveh Solhekol, Jeremy Page, Neville Scott, Chris Campling, Samson, Jack Malvern and Elizabeth Judge, Patrick Hosking, Roger Boyes, Gabriel Rozenberg Economics Reporter, Chloë Bryan-Brown, Feridun Ebassi, David Hands Rugby Correspondent, Tom Dart, Julian Muscat, Paul Simons, Chris Condron, Andrew Pierce and Tom Baldwin, Michelle Paver, Michelle Henery, Anne Ashworth, Joanna Pitman, Nigel Kendall, Terence F. Matthews, Mary Ann Sieghart, James Doran, Jonathan Clayton, Giles Whittell, Tosin Sulaiman, Peter Biddlecombe, Robert Crampton, Jane Shilling, Mel Webb, Julie Burchill, Charles Bremner and Marie Tourres, Jane Collins, Matthew Parris, George Caulkin, Jonathan Rendall, Tim Wapshott, Rebecca Ley, Caitlin Moran, Michael Austin, Sheila Keating, Iain Finlayson, Ben MacIntyre, Helen Pridham, Alison Gibson, Normal Giller, David Sinclair, John Naish, Graham Searjeant, Lewis Stuart, Annabelle Thorpe, Martin Waller, Alexandra Frean and Alexandra Blair, Christopher Irvine, Lisa Verrico, Mark Henderson, James Jackson, Ashling O'Connor, Benedict Nightingale, Angus Batey, Dr Thomas Stuttaford, Jill Crawshaw, Stephen Dalton, Bill Edgar, Alyson Rudd, Tom Chesshyre, Paul Connolly, James Christopher, Valerie Grove, D. R. Burton, Simon Crompton, Cath Urquhart Travel Editor, A. Rodriguez, Brian Clarke Fishing Correspondent, Jenny Davey, Jonathan Franzen, Brian Bishop, Peter Klinger, Joe Bolger, Martin Green, Chief Executive, Joe Campbell, Chief Executive, Elizabeth Judge Telecoms Correspondent, Irma Kurtz,
... Tom Chesshyre reports Fjord Norway Travel News Wendy Wu Tours Uzbekistan Fans All aboard Exclusively Online Turtle ...
2005 - Gale Group | TDA
Waseem Sharieff, Shi-an Yin, Michelle Wu, Qingjun Yang, Claudia Schauer, George Tomlinson, Stanley Zlotkin,
To examine consumption rates and serum ferritin (SF) concentrations (as a marker of safety) among schoolchildren (3-6 years) provided with daily and weekly micronutrients.Micronutrients were provided for one school term (13 weeks) to a kindergarten in northern China as single-dose Sprinkles sachets containing 30 mg of iron as encapsulated ferrous fumarate, 5 mg zinc gluconate, 50 mg vitamin C, 300 microg vitamin A, 7.5 microg vitamin D3 and 150 microg folic acid. Sixteen classrooms were randomly assigned ...
Tópico(s): Hemoglobinopathies and Related Disorders
2006 - Cambridge University Press | Public Health Nutrition
Giles Smith, Richard Mabey, Andrew Robson, Janice Turner, Christina Hardyment, John McNamara, Jon Ashworth, Cath Urquhart, David Adams, Richard Whitehead, Mousse, Benedict Cottrell Boyce, Nigel Colborn, Adam Sherwin Media Reporter, Dr Thomas Stuttaford and Suzi Godson, Jane MacQuitty, Simon Barnes, Jasper Rees, Magnus Linklater, Paul Hoggart, Tom Gard, Richard Hobson, Stephen D. Rountree (President and Chief Executive Officer), Ivo Tennant, Clare Lazaro, Olivia Lichtenstein, William Starling, Tony Turnbull, Philip Howard, Mykel Nicolaou, Hannah Betts, Carol Midgley, Shobna Gulati, Christine Seib, Tara Holmes, David Chater, Kenneth Stern (Chairman), Suna Erdem, James Bone, Rachel Campbell-Johnston, Dominic Wells, Nic Hopkins, Mom Rock, Clive Davis, Laura Peek, Rob Garrett and Kate Nevens, John Kenny, Elizabeth Judge, Gabrielle Starkey, Lucia Van Der Post, Ian Kelly, Iraq Burhan Wazir, Wendy Ide, Tristram Hunt, John Bungey, Kevin Eason, Angela Lindvall, Geoff Brown, Philippe Naughton, Clare Stewart, Pauline McLeod, Giles Coren, David Sharrock, Antonia Senior, Peter Draper (Director), Christine Lamb, Sir Roger Moore, Nancy Durrant, John Clarke, Howard Davies, Valerie Elliott, Rob Cassy, Mariella Frostrup, Katherine Swift, Steve Bird, July Skies, Jeremy Irons, Ruth Jamieson, Allan Simmons, Natasha Bedingfield, Dr Jane Collins, Tim Reid, Daniel Finkelstein, Angela Jameson Industrial Correspondent, Jeanette Winterson, Ruth Gledhill Religion Correspondent, Jane Clarke, MM, Tom Gatti, Candida Crewe, Jo Morris, Nick Robinson, Alan Hamilton, Peter Millar, Theresa May, Steve Harries, Denis Richmond, Steven Thomson, Mark Gatiss, Valerie Elliott Consumer Editor, Peter Newble, Roland Watson, Daisy Goodwin, David Hands, Tina Gaudoin, Charles Bremner, Richard Johnson, Ian MacKinnon, Ron Lewis, Stefanie Marsh, Sarah Tucker, Genevieve Fox, David Charter, Tim Teeman, Nigella Lawson, Derwent May, Sir Trevor McDonald, Angela Jameson, Harriet O'Brien, Ivan Hewett, John Mendelsohn, John Lawrence, Russell Kempson, Paula Hawkins, Timely Gifts, Peter Paphides, Adrian Woolfson, David Rowan, Dan Silver, Tony Halpin Education Editor, Richard Cork, Oliver Kay, Ed Potton, Nigel Williamson, Emanuele Paladino, Stephen Anderton, Amber Cowan, Lisa Grainger, Antony Bye, Mark Atherton, John Westerby, Lisa Armstrong, Rick Broadbent, Patrick Hosking Investment Editor, Tom Baldwin, Sam Coates, Chris Power, Dr Feelgood, Philip Webster and Peter Riddell, Murray Boldt, Credo Jonathan Sacks, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Marisa Leaf (Legal Officer), Celia Brayfield, Sheila Hancock, Magnus Grimond, Sarah Turner, Stuart Miles, Gabriel Rozenberg, Benjamin Fry, Jack Nicholson, Raymond Keene, Joanna Lumley, Adam Sage, Suzi Godson, Lewis Smith, Matthew Pryor, Alan Filmer, Matt Dickinson, Richard Brass, Fiona Morrow, Gordon Ramsay, Peter Stothard, Paul Levy, Michael Poole, Royal Doulton, Richard Dixon, Kaveh Solhekol, Jeremy Page, Clare Longrigg, Chris Campling, Ellin Stein, Edwin Booth, Patrick Hosking, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, Alex Hawkes, Erica Wagner, Marcel Berlins, Jeremy Paxman, Susie Amy, Bridget Chapple Table Talk, Barry Shooter, Chloë Bryan-Brown, James Naughtie, Moira Lavery Callaghan, Graham Searjeant Personal Investor, Bill Bryson, David Hands Rugby Correspondent, Tom Dart, Victoria O'brien, Julian Muscat, Paul Simons, Robin Lane Fox, Adam Fresco, Chris Condron, Anna Frame, Marie Tourres and Elsa Brely, Michelle Henery, Sam Mcknight, Anne Ashworth, John Goodbody, Dominic Kennedy, Santa Myth, Joanna Pitman, James Doran, Tom Cox, Nigel Kendall, Mark Morris, Leo Lewis and Ben Hoyle, Robert Crampton, Jane Shilling, Craig Lord, Julie Burchill, Matthew Parris, Graham Searjeant Financial Editor, Adrian Edmondson, Anjana Ahuja, Amanda Craig, Jonathan Rendall, Tim Wapshott, Russell Jenkins, Caitlin Moran, Sheila Keating, Rebecca Ley, Hugh Fearnley-Whittingstall, Iain Finlayson, Anthony Loyd, Peter Riddell, Ben MacIntyre, Antony Beevor, Brian Glanville, David James, John Carey, Alison Gibson, John Naish, Anne Ashworth Personal Finance Editor, Annabelle Thorpe, Catherine Philp, Martin Waller, Michael Horsnell, Chris Ayres, Frank Gehry (Architect), Kate Quill, Richard Thompson (Solicitor), Sarah Butler, Darian Leader, Oliver Kamm, Benedict Nightingale, Dalya Alberg and Sean O'Neill, Valerie Elliott and Shirley English, Jonathan Meades, Stephen Dalton, Jill Crawshaw, Anna-Marie Crowhurst, Alyson Rudd, Paul Connolly, Tom Chesshyre, James Christopher, Fred Dellar, Abigail Rayner, Simon Crompton, Alan Lee Racing Correspondent, Sebastian Smith, Owen Slot, Cath Urquhart Travel Editor, Louise Hancock, Douglas Kennedy, Daphne Lockyer, Colin Rafferty, Clare Simmons, Richard Ford, Peter Klinger, Patience Wheatcroft, Joe Bolger, Lisa Verrico, Irma Kurtz, Bad Santa, Stephen Pollard,
... catalogue Rock the Poques topten albums Ambient Classical Wu Man and the New Professionals Sony Various Artists ...
2004 - Gale Group | TDA
Libraries have supported multiple formats for decades, from paper and microforms to audiovisual tapes and CDs. However, the newest medium, digital transmission, has presented a wider scope of challenges and caused library patrons to question the established and recognized multiformat library. Within the many questions posed, two distinct ones echo repeatedly. The first doubts the need to sustain print in an increasingly digital world, and the second warns of the dangers of relying on a still-developing ...
Tópico(s): Artificial Intelligence in Law
2005 - | Law library journal
Tunku Varadarajan, Jon Ashworth, Andrew Rayment, Geoffrey Lewis, Edward Owen, Paul Wilkinson and Ben Preston, Andrew Pierce, John Daniel Vice-Chancellor, Patricia Davies, Janet Byrne, Catherine Milton, Social Services Correspondent, Magnus Linklater, Adam Sage and Roger Maynard, B. G. P. McKechnie, Nicholas Watt and Bill Frost, Tibor Fischer, S. W. Firth, Janet Bush, Economics Correspondent, Harvey Elliott, Ivo Tennant, Matt Wolf, Philip Howard, Nicholas Wood and Alice Thomson, Jeremy Kingston, John Habgood, Joseph Williams, Clive Davis, Derick R. Walker, Carl Mortished, Nick Nuttall, Environment Correspondent, Dominique Searle, D. Hugh Davidson, Simon Wilde, Colin Narbrough, Geoff Brown, Robert Sheehan, Bridge Correspondent, Robert Miller, Martin Fletcher, Pat Gibson, Mrs John Bowlby, Rupert Cox, Duncan McLean, Renée Obbard, Dominic King, Kris Anderson, Michelle MacPherson, David Gould, Robin Borwick, John O'leary, Education Editor, Raymond Keene Chess Correspondent, Martin Barrow, Dalya Alberge Arts Correspondent, Libby Purves, Peter Ackroyd, Matthew Parris Political Sketch, Peter Waymark, Richard Ford Home Correspondent, Peter Hughes, Alan Hamilton, Robin Young, Robert Nye, Robert Bruce, Michael Clark, Gerald Ratzin, Janet Bush, Patrick Gale, John Keegan, Ian McIntyre, Charlene Fu, Peter Barnard, Stacy Sullivan, Eve-Ann Prentice and Philip Webster, Philip Bassett, Industrial Editor, Tim McGuire, Kate Muir, Patricia Tehan, Banking Correspondent, Fiona Pitt-Kethley, Harold James, Giles Radice, Ian MacKillop, George Brock, Ursula Bowlby, Janet Daley, Michael Theodoulou, Lucy Berrington, Paul Sexton, Gillian Bowditch, John Hopkins Golf Correspondent, Brian Reading, Jim Duffy, David Powell Athletics Correspondent, Raymond Keene, Christine Buckley, Peter Davalle, Alan Lee, Cricket Correspondent, Emma Wilkins, Frances Gibb, Legal Correspondent, Paul Wilkinson, P. H. S, Lawrence Freedman, Richard Evans, Patrick A. H. Baily, Eric Reguly, Oliver Holt, Catherine Larthe, Roger Boyes, Philip Webster, Political Editor, Kate Alderson, Dalya Alberge, Julian Muscat, Ian Murray, Community Correspondent, Dr James Le Fanu, William Rees-Mogg, Dominic Kennedy, David Churchill, John Goodbody, Giles Whittell, Chris Parker, Kevin Bubel, E. N. Ingway, Andrew Seward, Amanda Craig, John Shaw, Peter Riddell, Ben MacIntyre, M. A. Crooks, Richard Beeston, Philip Pangalos, Myriel Davies, Kate Bassett, Martin Waller, Michael Horsnell, Benedict Nightingale, Tom Rhodes, Eve-Ann Prentice, Diplomatic Correspondent, and Adam Sage, Marianne Curphey, Jill Sherman, Political Correspondent, Frances Gibb Legal Correspondent, Dr Thomas Stuttaford, C. P. Addis (Librarian), Michael Evans Defence Correspondent, Jack Bailey, Sam Kiley, Michael Henderson, Michael Evans, June Charney, Martin Waller Deputy City Editor, Matthew Bond, Colin Campbell, John Ryan, Jolyon Oxley (Secretary), Desmond Wright, Walter Ellis, Catherine Milton, Avril Z. Parker, Jonathan Mirsky, M. G. de St V. Atkins, Dudley Fishburn (Chairman of the Trustees),
... Bosnian conflict Riddell on Politics Ikea (AP): Activist Wu gets visit from US envoy Norwich Union Patten ...
1995 - Gale Group | TDA
Eric Rios‐Doria, Amir Momeni Boroujeni, Claire F. Friedman, Pier Selenica, Qin Zhou, Michelle Wu, Antonio Marra, Mario M. Leitão, Alexia Iasonos, Kaled M. Alektiar, Yukio Sonoda, Vicky Makker, Elizabeth L. Jewell, Ying L. Liu, Dennis Chi, Dimitry Zamarin, Nadeem R. Abu‐Rustum, Carol Aghajanian, Jennifer J. Mueller, Lora H. Ellenson, Britta Weigelt,
Purpose Using next generation sequencing (NGS), The Cancer Genome Atlas (TCGA) found that endometrial carcinomas (ECs) fall under one of four molecular subtypes, and a POLE mutation status, mismatch repair (MMR) and p53 immunohistochemistry (IHC)-based surrogate has been developed. We sought to retrospectively classify and characterize a large series of unselected ECs that were prospectively subjected to clinical sequencing by utilizing clinical molecular and IHC data. Experimental design All patients ...
Tópico(s): Cancer-related molecular mechanisms research
2023 - Elsevier BV | Gynecologic Oncology
David Hoyos, Roberta Zappasodi, Isabell Schulze, Zachary Sethna, Kelvin C. de Andrade, Dean F. Bajorin, Chaitanya Bandlamudi, Margaret K. Callahan, Samuel A. Funt, Sine Reker Hadrup, Jeppe Sejerø Holm, Jonathan E. Rosenberg, Sohrab P. Shah, Ignacio Vázquez-Garćıa, Britta Weigelt, Michelle Wu, Dmitriy Zamarin, Laura F. Campitelli, Edward J. Osborne, Mark Klinger, Harlan Robins, Payal P. Khincha, Sharon A. Savage, Vinod P. Balachandran, Jedd D. Wolchok, Matthew D. Hellmann, Taha Merghoub, Arnold J. Levine, Marta Łuksza, Benjamin Greenbaum,
Missense driver mutations in cancer are concentrated in a few hotspots1. Various mechanisms have been proposed to explain this skew, including biased mutational processes2, phenotypic differences3-6 and immunoediting of neoantigens7,8; however, to our knowledge, no existing model weighs the relative contribution of these features to tumour evolution. We propose a unified theoretical 'free fitness' framework that parsimoniously integrates multimodal genomic, epigenetic, transcriptomic and proteomic ...
Tópico(s): Mathematical Biology Tumor Growth
2022 - Nature Portfolio | Nature
Charles Ashley, Pier Selenica, Juber Patel, Michelle Wu, Josip Ninčević, Yulia Lakhman, Qin Zhou, Ronak Shah, Michael F. Berger, Arnaud Da Cruz Paula, David Brown, Antonio Marra, Alexia Iasonos, Amir Momeni Boroujeni, Kaled M. Alektiar, Kara Long Roche, Oliver Zivanovic, Jennifer J. Mueller, Dmitriy Zamarin, Vance Broach, Yukio Sonoda, Mario M. Leitão, Claire F. Friedman, Elizabeth L. Jewell, Jorge S. Reis‐Filho, Lora H. Ellenson, Carol Aghajanian, Nadeem R. Abu‐Rustum, Karen A. Cadoo, Britta Weigelt,
Abstract Purpose: We sought to determine whether sequencing analysis of circulating cell-free DNA (cfDNA) in patients with prospectively accrued endometrial cancer captures the mutational repertoire of the primary lesion and allows for disease monitoring. Experimental Design: Peripheral blood was prospectively collected from 44 newly diagnosed patients with endometrial cancer over a 24-month period (i.e., baseline, postsurgery, every 6 months after). DNA from the primary endometrial cancers was subjected ...
Tópico(s): Sarcoma Diagnosis and Treatment
2022 - American Association for Cancer Research | Clinical Cancer Research
Ignacio Vázquez-Garćıa, Florian Uhlitz, Nicholas Ceglia, Jamie Lim, Michelle Wu, Neeman Mohibullah, Juliana Niyazov, Arvin Eric B. Ruiz, Kevin M. Boehm, Viktoria Bojilova, Christopher J. Fong, Tyler Funnell, Diljot Grewal, Eliyahu Havasov, Samantha Leung, Arfath Pasha, Druv Patel, Maryam Pourmaleki, Nicole Rusk, Hongyu Shi, R. Vanguri, Marc Williams, Allen W. Zhang, Vance Broach, S. Dennis, Arnaud Da Cruz Paula, Ginger J. Gardner, Sarah H. Kim, Matthew Lennon, Kara Long Roche, Yukio Sonoda, Oliver Zivanovic, Ritika Kundra, Agnès Viale, Fatemeh Derakhshan, Luke Geneslaw, Shirin Issa Bhaloo, Ana Maroldi, Rahelly Nunez, Fresia Pareja, Anthe A. Stylianou, Mahsa Vahdatinia, Yonina Bykov, Rachel N. Grisham, Ying L. Liu, Yulia Lakhman, Ines Nikolovski, Daniel J. Kelly, Jianjiong Gao, Andrea Schietinger, Travis J. Hollmann, Samuel F. Bakhoum, Robert A. Soslow, Lora H. Ellenson, Nadeem R. Abu‐Rustum, Carol Aghajanian, Claire F. Friedman, Andrew McPherson, Britta Weigelt, Dmitriy Zamarin, Sohrab P. Shah,
Abstract High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability 1–4 patterned by distinct mutational processes 5,6 , tumour heterogeneity 7–9 and intraperitoneal spread 7,8,10 . Immunotherapies have had limited efficacy in HGSOC 11–13 , highlighting an unmet need to assess how mutational processes and the anatomical sites of tumour foci determine the immunological states of the tumour microenvironment. Here we carried out an integrative analysis of whole-genome sequencing, ...
Tópico(s): Ovarian cancer diagnosis and treatment
2022 - Nature Portfolio | Nature
Arnaud Da Cruz Paula, Deborah F. DeLair, Lorenzo Ferrando, Daniel Fix, Robert A. Soslow, Kay J. Park, Sarah Chiang, Jorge S. Reis‐Filho, Ahmet Zehir, Mark T.A. Donoghue, Michelle Wu, David Brown, Rajmohan Murali, Claire F. Friedman, Dmitriy Zamarin, Vicky Makker, Jennifer J. Mueller, Mario M. Leitão, Nadeem R. Abu‐Rustum, Carol Aghajanian, Britta Weigelt,
Objective To characterize and compare the molecular subtypes and profiles of prospectively-accrued newly-diagnosed early- and advanced-stage endometrial cancers (ECs). Methods EC patients consented to an IRB-approved protocol of massively parallel sequencing of 410–468 cancer-related genes; 175 ECs of 7 histologic types (n = 135 FIGO stages I/II, n = 40 FIGO stages III/IV) were included. Previously reported sequencing data from 99 additional advanced-stage ECs were retrieved for comparisons. Results Irrespective ...
Tópico(s): Sarcoma Diagnosis and Treatment
2021 - Elsevier BV | Gynecologic Oncology
Michelle Wu, Ruth Antony, Harvey N. Mayrovitz,
Melasma is a benign yet psychologically debilitating skin condition that is prevalent among women of darker phenotypes, and particularly in Asian women. This potentially preventable condition can lead to skin discoloration that is hard to treat and can frequently recur. This review aims to (1) highlight the pathophysiology of melasma, (2) describe its important risk factors, and (3) identify prevention methods, available treatment options, and potential complications of melasma. By raising awareness ...
Tópico(s): Skin Protection and Aging
2021 - Cureus, Inc. | Cureus
Vuk Bortnik, Michelle Wu, Bryan Julcher, Ana Salinas, Iva Nikolić, Kaylene J. Simpson, Nigel A.J. McMillan, Adi Idris,
Human papilloma viruses (HPV) are the main culprit in cervical and oropharyngeal cancers. HPV positive (+) cancers are regarded as 'oncogene addicted', displaying an absolute requirement for the continued expression of the oncogenes for their viability owing their survival, and thus making these genes salient targets for developing specific therapeutic agents. There is a strong association between HPV and oropharyngeal squamous cell carcinomas (OPSCC), a subset of head and neck cancers (HNCs). Alarmingly, ...
Tópico(s): RNA modifications and cancer
2020 - Elsevier BV | Journal of Microbiology Immunology and Infection
Ou Wang, Robert Chin, Xiaofang Cheng, Michelle Wu, Qing Mao, Jingbo Tang, Yuhui Sun, Ellis Anderson, Han K. Lam, Dan Chen, Yujun Zhou, Linying Wang, Fei Fan, Yan Zou, Yinlong Xie, Rebecca Yu Zhang, Snezana Drmanac, Darlene Nguyen, Chongjun Xu, Christian Villarosa, Scott Gablenz, Nina Barua, Staci Nguyen, Wenlan Tian, Jia Sophie Liu, Jingwan Wang, Xiao Liu, Xiaojuan Qi, Ao Chen, He Wang, Yuliang Dong, Wenwei Zhang, Andrei Alexeev, Huanming Yang, Jian Wang, Karsten Kristiansen, Xun Xu, Radoje Drmanac, Brock A. Peters,
Here, we describe single-tube long fragment read (stLFR), a technology that enables sequencing of data from long DNA molecules using economical second-generation sequencing technology. It is based on adding the same barcode sequence to subfragments of the original long DNA molecule (DNA cobarcoding). To achieve this efficiently, stLFR uses the surface of microbeads to create millions of miniaturized barcoding reactions in a single tube. Using a combinatorial process, up to 3.6 billion unique barcode ...
Tópico(s): Bacteriophages and microbial interactions
2019 - Cold Spring Harbor Laboratory Press | Genome Research
Shangming Tang, Michelle Wu, Ruoxi Zhang, Neil Hunter,
The Bloom’s helicase ortholog, Sgs1, plays central roles to coordinate the formation and resolution of joint molecule intermediates (JMs) during meiotic recombination in budding yeast. Sgs1 can associate with type-I topoisomerase Top3 and its accessory factor Rmi1 to form a conserved complex best known for its unique ability to decatenate double-Holliday junctions. Contrary to expectations, we show that the strand-passage activity of Top3-Rmi1 is required for all known functions of Sgs1 in meiotic ...
Tópico(s): Nuclear Structure and Function
2015 - Elsevier BV | Molecular Cell
Susan Davies Gfroerer, Shari L. Wade, Michelle Wu,
Primary objective: To determine whether parents believe schools provided necessary support to their children who sustained traumatic brain injuries.Research design: Interview, to determine parent perceptions.Methods and procedure: Sixty-six primary caregivers of school-age children who experienced a TBI within the previous 2 years were interviewed regarding what types of special support were needed by and provided for their children during the 3 months immediately following school re-entry. They ...
Tópico(s): Cardiac Arrest and Resuscitation
2008 - Taylor & Francis | Brain Injury
Marc D. Meneghini, Michelle Wu, Hiten D. Madhani,
Boundary elements hinder the spread of heterochromatin, yet these sites do not fully account for the preservation of adjacent euchromatin. Histone variant H2A.Z (Htz1 in yeast) replaces conventional H2A in many nucleosomes. Microarray analysis revealed that HTZ1-activated genes cluster near telomeres. The reduced expression of most of these genes in htz1Δ cells was reversed by the deletion of SIR2 (sir2Δ) suggesting that H2A.Z antagonizes telomeric silencing. Other Htz1-activated genes flank the silent ...
Tópico(s): Epigenetics and DNA Methylation
2003 - Cell Press | Cell
Michelle Wu, Geoffrey Lee, Gayle Fischer,
Vulvar lichen planus is a debilitating skin condition usually complicated by delayed diagnosis due to its highly variable clinical appearance and inconsistent histopathological characteristics. This study aims to devise a clinical diagnostic tool for the disease and to correlate this with histopathology findings.The retrospective single-centre chart review was conducted for patients presenting between January 2010 and December 2019. Clinical features were compared between 243 women with clinically ...
Tópico(s): Nail Diseases and Treatments
2020 - Wiley | Australasian Journal of Dermatology
Lisa Americo, Amit Ramjit, Michelle Wu, Leif Jensen, Drew M. Caplin, Joseph P. Mazzie, Glenn C. Gaviola, James Milburn, Christopher P. Ho, Maitray D. Patel, Carolynn M. DeBenedectis, Darel E. Heitkamp, David Sarkany,
As the population of the United States grows increasingly diverse, health care disparities become vital to understand and mitigate. The ethical and financial implications of how groups of Americans gain access to health care have evolved into some of today's most challenging socioeconomic problems. Educators in radiology are just beginning to tackle the concepts of health care disparities, unconscious bias, and cultural competency. In July 2017, the Accreditation Council for Graduate Medical Education ...
Tópico(s): Diversity and Career in Medicine
2018 - Elsevier BV | Current Problems in Diagnostic Radiology
Lea A. Moukarzel, Maureen Byrne, Stephanie Leiva, Michelle Wu, Qin Zhou, Alexia Iasonos, Nadeem R. Abu‐Rustum, Yukio Sonoda, Ginger J. Gardner, Mario M. Leitão, Vance Broach, S. Dennis, Kara Long Roche, Oliver Zivanovic,
Objectives Reducing anastomotic leak rates after rectosigmoid resection and anastomosis is a priority in patients undergoing gynecologic oncology surgery. Therefore, we investigated the implications of performing near-infrared angiography (NIR) via proctoscopy to assess anastomotic perfusion at the time of rectosigmoid resection and anastomosis. Methods We identified all patients who underwent rectosigmoid resection and anastomosis for a gynecologic malignancy between January 1, 2013 and December ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2020 - Elsevier BV | Gynecologic Oncology
Ivy X. Chen, Vikash P. Chauhan, Jessica M. Posada, Mei Rosa Ng, Michelle Wu, Pichet Adstamongkonkul, Peigen Huang, Neal I. Lindeman, Róbert Langer, Rakesh K. Jain,
... Vikash P. Chauhan, Jessica Posada, Mei R. Ng, Michelle Wu, Pichet Adstamongkonkul, Peigen Huang, Neal Lindeman, Robert Langer, ...
Tópico(s): Cancer Research and Treatments
2019 - SAGE Publishing | Tumor Biology
Lea A. Moukarzel, Lorenzo Ferrando, Anthe A. Stylianou, Stephanie Lobaugh, Michelle Wu, Silvana Pedra Nobre, Alexia Iasonos, Gabriele Zoppoli, Dilip D. Giri, Nadeem R. Abu‐Rustum, Vance Broach, Neil M. Iyengar, Britta Weigelt, Vicky Makker,
Background A complex relationship between adipose tissue and malignancy, involving an inflammatory response, has been reported. The goal of this work was to assess the prevalence of white adipose tissue (WAT) inflammation in patients with endometrial cancer (EC), and the association with circulating inflammation markers. Furthermore, the aim was to characterize the pathways activated in and the cell type composition of adipose tissue in patients with EC. Methods Adipose tissue and blood samples were ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2022 - Wiley | Cancer
While library models already exist for sharing physical materials and joint licensing, this paper envisions an aspect of future collections involving a national digital collection owned, not licensed, by libraries. Collaborative collection development, digitization, and digital object management of owned collections can benefit societies in multiple ways, from expanding access to users otherwise unable to reach these materials, to preserving content even when disaster strikes, to reducing duplication ...
Tópico(s): Library Collection Development and Digital Resources
2019 - Taylor & Francis | Collection Management
Digitize-and-lend library projects can benefit societies in multiple ways, from providing information to people in remote areas or with physical disabilities to facilitating the sharing of library resources with information-poor communities. This article explores the potential of digitize and lend as well as outlines how projects can be undertaken in a manner respectful of the balance of copyright.
Tópico(s): FinTech, Crowdfunding, Digital Finance
2017 - Taylor & Francis | Legal Reference Services Quarterly
Law libraries are losing ground in the effort to preserve information in the digital age. In part, this is due declining budgets, user needs, and a caution born from the great responsibility libraries feel to ensure future access instead of selecting a form that may not survive. That caution, though, has caused others, such as Google, to fill the silence with their vision. Libraries must stand and contribute actively to the creation of digital collections if we expect a voice in future discussion. ...
Tópico(s): Law, AI, and Intellectual Property
2011 - RELX Group (Netherlands) | SSRN Electronic Journal
Brenda Bursch, Jessica C. Lloyd, Catherine Mogil, Kanchana Wijesekera, Karen Miotto, Michelle Wu, Rebecca Wilkinson, Alexandra M. Klomhaus, Arija Iverson, Patricia Lester,
An evidence-based trauma-informed resilience skills training program developed for deployed military personnel was adapted and pilot-tested with pediatric residents. We anticipated high satisfaction ratings and changes in knowledge, beliefs, and self-efficacy related to coping with stress and trauma.The intervention included 6 skill-based modules covering emotion regulation, communication with angry patients and parents, reflective narrative, inspirational goal setting, problem-solving, and developing ...
Tópico(s): Posttraumatic Stress Disorder Research
2017 - SAGE Publishing | Journal of Medical Education and Curricular Development
The measurement of the half-life of the superallowed positron decay of ${}^{38}{\mathrm{K}}^{m}$ has been studied with particular reference to possible systematic effects involved. A value of 924.4(6) ms has been found. A recommendation is made that certain earlier values are rejected, and that a mean lifetime of 924.24(27) ms is accepted. This leads to an $\mathrm{Ft}$ value of 3071.8(19) s, where the overwhelming contribution to the error comes from uncertainties in the electromagnetic corrections.
Tópico(s): Muon and positron interactions and applications
2000 - American Institute of Physics | Physical Review C
Keene L. Abbott, Ahmed Ali, Dominick Casalena, T. Brian, Raphaël Ferreira, Jaime H. Cheah, Christian K. Soule, Amy Deik, Tenzin Kunchok, Daniel R. Schmidt, Steffen Renner, Sophie Honeder, Michelle Xiao Wu, Sze Ham Chan, Tenzin Tseyang, Andrew T. Stoltzfus, Sarah L. J. Michel, Daniel Greaves, Peggy P. Hsu, Christopher Ng, Chelsea J. Zhang, Ali Farsidjani, Johnathan R. Kent, Maria Lucia L. Madariaga, Iva Monique T. Gramatikov, Nicholas J. Matheson, Caroline A. Lewis, Clary B. Clish, Matthew G. Rees, Jennifer A. Roth, Lesley A. Mathews Griner, Alexander Muir, Douglas S. Auld, Matthew G. Vander Heiden,
A challenge for screening new anticancer drugs is that efficacy in cell culture models is not always predictive of efficacy in patients. One limitation of standard cell culture is a reliance on non-physiological nutrient levels, which can influence cell metabolism and drug sensitivity. A general assessment of how physiological nutrients affect cancer cell response to small molecule therapies is lacking. To address this, we developed a serum-derived culture medium that supports the proliferation ...
Tópico(s): Bioinformatics and Genomic Networks
2023 - Elsevier BV | Cell chemical biology
Johan O. L. Andreasson, Michael R. Gotrik, Michelle J. Wu, Hannah K. Wayment-Steele, Wipapat Kladwang, Fernando Gutiérrez Pórtela, Roger Wellington-Oguri, Rhiju Das, William J. Greenleaf,
Internet-based scientific communities promise a means to apply distributed, diverse human intelligence toward previously intractable scientific problems. However, current implementations have not allowed communities to propose experiments to test all emerging hypotheses at scale or to modify hypotheses in response to experiments. We report high-throughput methods for molecular characterization of nucleic acids that enable the large-scale video game–based crowdsourcing of RNA sensor design, followed ...
Tópico(s): Bacteriophages and microbial interactions
2022 - National Academy of Sciences | Proceedings of the National Academy of Sciences