Koji Shinozaki, Toshihiko Miyagi, Michio Yoshida, Takaki Miyata, Masaharu Ogawa, Shinichi Aizawa, Yoko Suda,
Emx1 and Emx2, mouse orthologs of the Drosophila head gap gene, ems, are expressed during corticogenesis. Emx2 null mutants exhibit mild defects in cortical lamination. Segregation of differentiating neurons from proliferative cells is normal for the most part, however, reelin-positive Cajal-Retzius cells are lost by the late embryonic period. Additionally, late-born cortical plate neurons display abnormal position. These types of lamination defects are subtle in the Emx1 mutant cortex. In the present ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2002 - The Company of Biologists | Development
Tetsuji Yamashita, Yohei Miyagi, Michio Ono, Hiroaki Ito, Keiko Watanabe, Tomoko Sonoda, Keisuke Tsuzuki, Seiji Ozawa, Ichiro Aoki, Kenji Okuda, Masayoshi Mishina, Susumu Kawamoto,
Delphilin is identified as a Glutamate receptor δ2 (GluRδ2) subunit interacting protein, consisting of a PDZ domain and formin homology (FH) domains 1 and 2, in addition to a C-terminal coiled-coil structure. Delphilin has been shown to be selectively expressed in cerebellar Purkinje cells where it co-localizes with the GluRδ2 subunit at the Purkinje cell-parallel fiber synapses. Although Delphilin specifically interacts with the GluRδ2 C-terminus via its PDZ domain, the physiological role of the ...
Tópico(s): interferon and immune responses
2005 - Elsevier BV | Molecular Brain Research
... Shõwa 30-nen rinji nõgyõ kihon chõsa. Sendai, Miyagi-ken Sõmubu Chõsaka. Nagai, Michio 1953 Dõzoku: a preliminary study of the Japanese “ ...
Tópico(s): Japanese History and Culture
1961 - Wiley | American Anthropologist
Miyagi Michio (1894-1956), koto performer, composer, and educator, was a musical innovator who modified traditional instruments, incorporated ...
Tópico(s): Music Education and Analysis
2005 - | Asian Music
Takashi Oshima, Takaki Yoshikawa, Yohei Miyagi, Satoshi Morita, Michio Yamamoto, Kazuaki Tanabe, Kazuhiro Nishikawa, Yuichi Ito, Takanori Matsui, Yutaka Kimura, Tomoyuki Yokose, Yukihiko Hiroshima, Toru Aoyama, Tsutomu Hayashi, Takashi Ogata, Haruhiko Cho, Yasushi Rino, Munetaka Masuda, Akira Tsuburaya, Junichi Sakamoto,
// Takashi Oshima 1 , Takaki Yoshikawa 2 , Yohei Miyagi 3 , Satoshi Morita 4 , Michio Yamamoto 5 , Kazuaki Tanabe 6 , Kazuhiro Nishikawa 7 , Yuichi Ito 8 , Takanori Matsui 9 , Yutaka Kimura 10 , Tomoyuki Yokose 13 , Yukihiko Hiroshima 3 , ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2020 - Impact Journals LLC | Oncotarget
... study of Western art music in this regard. Miyagi Michio, the founder of the shinnihon ongaku (new Japanese ...
Tópico(s): Korean Peninsula Historical and Political Studies
2006 - | Asian Music
Hiraku Miyagi, Michio Hiroshima, Yasushi Sako,
Growth factors regulate cell fates, including their proliferation, differentiation, survival, and death, according to the cell type. Even when the response to a specific growth factor is deterministic for collective cell behavior, significant levels of fluctuation are often observed between single cells. Statistical analyses of single-cell responses provide insights into the mechanism of cell fate decisions but very little is known about the distributions of the internal states of cells responding ...
Tópico(s): Single-cell and spatial transcriptomics
2020 - Elsevier BV | Biosystems
Takashi Okada, Hiraku Miyagi, Yasushi Sako, Michio Hiroshima, Atsushi Mochizuki,
Intercellular signals induce various cellular responses, including growth, proliferation, and differentiation, via the dynamic processes of signal transduction pathways. For cell fate decisions, ligand-binding induces the phosphorylation of ERBB receptors, which in turn activate downstream molecules. The ERBB family includes four subtypes, which diverged through two gene duplications from a common ancestor. Differences in the expression patterns of the subtypes have been reported between different ...
Tópico(s): Microtubule and mitosis dynamics
2021 - Elsevier BV | Biophysical Journal
Kazuyoshi Kobayashi, Shiro Imagama, Kei Ando, Naoki Ishiguro, Masaomi Yamashita, Yawara Eguchi, Morio Matsumoto, Ken Ishii, Tomohiro Hikata, Shoji Seki, Hidetomi Terai, Akinobu Suzuki, Koji Tamai, Masaaki Aramomi, Tetsuhiro Ishikawa, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Kei Yamada, Michio Hongo, Yuji Matsuoka, Hidekazu Suzuki, Atsushi Nakano, Kazuyuki Watanabe, Hirotaka Chikuda, Junichi Ohya, Yasuchika Aoki, Masayuki Shimizu, Toshimasa Futatsugi, Keijiro Mukaiyama, Masaichi Hasegawa, Katsuhito Kiyasu, Haku Iizuka, Yoichi Iizuka, Ryoichi Kobayashi, Kotaro Nishida, Kenichiro Kakutani, Hideaki Nakajima, Hideki Murakami, Satoru Demura, Satoshi Kato, Katsuhito Yoshioka, Takashi Namikawa, Kei Watanabe, Kazuyoshi Nakanishi, Yukihiro Nakagawa, Mitsunori Yoshimoto, Hiroyasu Fujiwara, Norihiro Nishida, Yasuaki Imajo, Masashi Yamazaki, Masataka Sakane, Tetsuya Abe, Kengo Fujii, Takashi Kaito, Takeo Furuya, Sumihisa Orita, Seiji Ohtori,
Retrospective database analysis.Spine surgeries in elderly patients have increased in recent years due to aging of society and recent advances in surgical techniques, and postoperative complications have become more of a concern. Postoperative delirium is a common complication in elderly patients that impairs recovery and increases morbidity and mortality. The objective of the study was to analyze postoperative delirium associated with spine surgery in patients aged 80 years or older with cervical, ...
Tópico(s): Anesthesia and Sedative Agents
2017 - SAGE Publishing | Global Spine Journal
Kazuyoshi Kobayashi, Shiro Imagama, Kei Ando, Naoki Ishiguro, Masaomi Yamashita, Yawara Eguchi, Morio Matsumoto, Ken Ishii, Tomohiro Hikata, Shoji Seki, Hidetomi Terai, Akinobu Suzuki, Koji Tamai, Masaaki Aramomi, Tetsuhiro Ishikawa, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Kei Yamada, Michio Hongo, Hirosuke Nishimura, Hidekazu Suzuki, Atsushi Nakano, Kazuyuki Watanabe, Hirotaka Chikuda, Junichi Ohya, Yasuchika Aoki, Masayuki Shimizu, Toshimasa Futatsugi, Keijiro Mukaiyama, Masaichi Hasegawa, Katsuhito Kiyasu, Haku Iizuka, Yoichi Iizuka, Ryoichi Kobayashi, Kotaro Nishida, Kenichiro Kakutani, Hideaki Nakajima, Hideki Murakami, Satoru Demura, Satoshi Kato, Katsuhito Yoshioka, Takashi Namikawa, Kei Watanabe, Kazuyoshi Nakanishi, Yukihiro Nakagawa, Mitsunori Yoshimoto, Hiroyasu Fujiwara, Norihiro Nishida, Yasuaki Imajo, Masashi Yamazaki, Masataka Sakane, Tetsuya Abe, Kengo Fujii, Takashi Kaito, Takeo Furuya, Sumihisa Orita, Seiji Ohtori,
Retrospective study of registry data.Aging of society and recent advances in surgical techniques and general anesthesia have increased the demand for spinal surgery in elderly patients. Many complications have been described in elderly patients, but a multicenter study of perioperative complications in spinal surgery in patients aged 80 years or older has not been reported. Therefore, the goal of the study was to analyze complications associated with spine surgery in patients aged 80 years or older ...
Tópico(s): Scoliosis diagnosis and treatment
2017 - SAGE Publishing | Global Spine Journal
Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Hiroyuki Fukui, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Kazuhiro Kaytayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Michio Kato, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Norio Hayashi,
Background & Aims This study investigated the efficacy and adverse effects of pegylated interferon (Peg-IFN) plus ribavirin therapy in aged patients with chronic hepatitis C (CH-C). Methods A total of 1040 naïve patients with CH-C (genotype 1, n = 759; genotype 2, n = 281), of whom 240 (23%) over 65 years old (y.o.), were treated with Peg-IFN alfa-2b plus ribavirin and assessed after being classified into five categories, according to age. Results The discontinuance rate was higher for patients over 70 y.o. ( ...
Tópico(s): Hepatitis B Virus Studies
2010 - Elsevier BV | Journal of Hepatology
Michio Nishioka, Tosio Miyagi,
The two-dimensional wake of a thin flat plate parallel to the stream was maintained laminar and steady at Reynolds numbers up to 3000 in a low-turbulence wind tunnel. Velocity distributions in the wake were measured in detail for Reynolds numbers from 20 to 3000. One of the interesting results is the appearance of a velocity overshoot, namely that the velocity in the outer part of the shear layer exceeds that of the uniform flow in the vicinity of the trailing edge. Comparisons between the experimental ...
Tópico(s): Aerodynamics and Fluid Dynamics Research
1978 - Cambridge University Press | Journal of Fluid Mechanics
Yuko Inoue, Naoki Hiramatsu, Tsugiko Oze, Takayuki Yakushijin, Kiyoshi Mochizuki, Hideki Hagiwara, Masahide Oshita, Eiji Mita, Hirokazu Fukui, Masami Inada, Satoru Tamura, Hiroyuki Yoshihara, Eiji Hayashi, Akira Inoue, Yoichi Imai, Michio Kato, Takuya Miyagi, A. Hohsui, Hisashi Ishida, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Norio Hayashi,
Summary. Reducing the dose of drug affects treatment efficacy in pegylated interferon (Peg-IFN) and ribavirin combination therapy for patients with hepatitis C virus (HCV) genotype 1. The aim of this study was to investigate the impact of drug exposure, as well as the baseline factors and the virological response on the treatment efficacy for genotype 2 patients. Two-hundred and fifty patients with genotype 2 HCV who were to undergo combination therapy for 24 weeks were included in the study, and ...
Tópico(s): Hepatitis B Virus Studies
2009 - Wiley | Journal of Viral Hepatitis
Ryoko Yamada, Naoki Hiramatsu, Tsugiko Oze, Naoki Morishita, Naoki Harada, Takayuki Yakushijin, Sadaharu Iio, Yoshinori Doi, Akira Yamada, Akira Kaneko, Hideki Hagiwara, Eiji Mita, Masahide Oshita, T Itoh, Hiroyuki Fukui, Taizo Hijioka, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Yasuharu Imai, Michio Kato, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Akinori Kasahara, Toshimitsu Hamasaki, Norio Hayashi, Tetsuo Takehara,
Tópico(s): Pancreatic and Hepatic Oncology Research
2014 - Springer Science+Business Media | Journal of Gastroenterology
Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Masanori Miyazaki, Akira Yamada, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Hiroyuki Fukui, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Eijiro Hayashi, Michio Kato, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Akinori Kasahara, Toshimitsu Hamasaki, Norio Hayashi, Tetsuo Takehara,
Background & Aims In patients with chronic hepatitis C virus (HCV) infection, lack of sustained virologic response (SVR) 24 weeks after the end of interferon therapy is a significant risk factor for hepatocellular carcinoma (HCC). Although many pretreatment factors are known to affect HCC incidence, less is known about post-treatment factors—many change during the course of interferon therapy. Methods We performed a prospective study, collecting data from 2659 patients with chronic hepatitis C without a history ...
Tópico(s): Hepatitis B Virus Studies
2013 - Elsevier BV | Clinical Gastroenterology and Hepatology
Tosio Miyagi, Michio Nishioka,
To account for our previous experimental results, the flow past a flat plate set parallel to a uniform stream is investigated on the basis of Oseen's equations of motion. We are mainly concerned with the wake region and calculate the velocity field in detail for the range of Reynolds numbers 20–3000, corresponding to the experiments. The calculation shows that there is a velocity overshoot in the velocity distribution near the trailing edge, with the same magnitude as in the experiments. Furthermore, ...
Tópico(s): Spacecraft and Cryogenic Technologies
1980 - Cambridge University Press | Journal of Fluid Mechanics
Shusaku Haranaga, Masao Tateyama, Futoshi Higa, Kazuya Miyagi, Morikazu Akamine, Masato Azuma, Satomi Yara, Michio Koide, Jiro Fujita,
Erythromycin (EM) and rifampicin (RFP) have mainly been used to treat patients with Legionella pneumonia. Since intravenous ciprofloxacin (CPFX) became available in Japan from 2000, many reports have been published detailing successful treatment of Legionella pneumonia with CPFX. In this study, we compared the evolution of patients with Legionella pneumonia treated with CPFX to those treated with EM.The study included nine patients treated with CPFX and eighteen patients treated with EM. Diagnosis ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2007 - The Japanese Society of Internal Medicine | Internal Medicine
Akihiro Yokoyama, Michio Murata, Yasukatsu Oshima, Takashi Iwashita, Takeshi Yasumoto,
... of Food Chemistry, Faculty of Agriculture, Tohoku UniversitySendai, Miyagi 980 Search for other works by this author on: Oxford Academic PubMed Google Scholar Michio Murata, Michio Murata *Department of Food Chemistry, Faculty of Agriculture, Tohoku UniversitySendai, Miyagi 980 Search for other works by this author ...
Tópico(s): Molecular Sensors and Ion Detection
1988 - Oxford University Press | The Journal of Biochemistry
H. Komatsu, Ryoji Mogi, Michio M. Matsushita, Tadashi Miyagi, Yuzo Kawada, Tadashi Sugawara,
Abstract A novel organic donor radical, TSBN, which is a benzotetraselenafulvalene derivative carrying a nitronyl nitroxide group in a cross-conjugated manner was prepared. X-ray crystallographic analysis revealed that TSBN forms a sheet-like network within the ac plane through intermolecular chalcogen contacts. Its spin-polarized structure was confirmed by cyclic voltammogram, ESR spectra of singly oxidized species and DFT calculation. The neutral crystal of TSBN showed nonlinear I–V characteristics ...
Tópico(s): Magnetism in coordination complexes
2009 - Elsevier BV | Polyhedron
Keisuke Kohga, Tetsuo Takehara, Tomohide Tatsumi, Kazuyoshi Ohkawa, Takuya Miyagi, Naoki Hiramatsu, Tatsuya Kanto, Tsutomu Kasugai, Kazuhiro Katayama, Michio Kato, Norio Hayashi,
Soluble forms of major histocompatibility complex (MHC) class I‐related chain A and B (MICA/B) are increased in the sera of patients with malignancy and impair the antitumor immune response by downregulating expression of their cognate immunoreceptor natural killer group 2, member D (NKG2D). Recently, soluble MICA/B were reported to appear even in some premalignant diseases, raising questions about the impact of soluble MICA/B produced from tumors on the expression of NKG2D. The present study examined ...
Tópico(s): Reproductive System and Pregnancy
2008 - Wiley | Cancer Science
... the New Japanese Movement and figures such as Miyagi Michio. There is also a detailed examination of the ...
Tópico(s): Musicology and Musical Analysis
2006 - | Asian Music
... of its contributions. Henry Johnson’s introduction of Miyagi Michio’s koto music as both modernist and traditionalist ...
Tópico(s): Japanese History and Culture
2014 - Cambridge University Press | Journal of Japanese Studies
Takeshi Yamamoto, Kenji Yodogawa, Satoshi Wakita, Michio Ogano, Miwa Tokita, Yasuo Miyagi, Naoki Sato, Takashi Nitta, Keiji Tanaka, Teruo Takano,
Infective endocarditis, a serious infection most commonly affecting rheumatic or prosthetic valves, generally occurs after bacteremia. Atopic dermatitis, a very common disease, carries a high prevalence of skin infections, particularly with Staphylococcus aureus. While cutaneous colonization by S. aureus represents an important source of bacteremia, few cases of infective endocarditis arising from the skin lesions of atopic dermatitis have been reported. We describe a patient with recurrent S. aureus ...
Tópico(s): Contact Dermatitis and Allergies
2007 - The Japanese Society of Internal Medicine | Internal Medicine
Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Kazuho Imanaka, Akira Yamada, Masahide Oshita, Akira Kaneko, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Toshihiko Nagase, Yoshiaki Inui, Taizo Hijioka, Shinji Tamura, Harumasa Yoshihara, Eijiro Hayashi, Yasuharu Imai, Michio Kato, Atsushi Hosui, Takuya Miyagi, Yuichi Yoshida, Hisashi Ishida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Norio Hayashi,
Tópico(s): Hepatitis B Virus Studies
2011 - Springer Science+Business Media | Journal of Gastroenterology
Michio Fukuda, Masahiro Motokawa, Sota Miyagi, Kinya Sengo, Wataru Muramatsu, Nobuo Kato, Takeshi Usami, Atsuhiro Yoshida, Genjiro Kimura,
Background. Nocturnal polyuria has been well known in renal insufficiency. Recently, we found that as renal function deteriorated in chronic kidney disease (CKD), natriuresis was enhanced during the night with nocturnal blood pressure elevation. In the present study, we investigated whether nocturnal polyuria in CKD was due to the inability to concentrate urine, as previously proposed, or based on osmotic diuresis mainly by natriuresis. Methods. In 27 CKD patients, circadian rhythms of urinary sodium, ...
Tópico(s): Blood Pressure and Hypertension Studies
2006 - Oxford University Press | Nephrology Dialysis Transplantation
Noriaki Ohuchi, Koichi Yoshida, Michio Kimura, Akio Ouchi, Kenichi Shiiba, Koji Ohnuki, Akira Fukao, Rikiya Abe, Seiki Matsuno, Shozo Mori,
False negative rates were compared in two screening modalities, physical examination with or without mammography, in an intervention study for women aged over 50 in Miyagi Prefecture. Thirty‐five breast cancers were detected in 12,515 subjects who participated in the trial consisting of physical examination and mammography, whereas 44 breast cancers were detected in 50,105 subjects who received physical examination alone, so that the detection rates were 0.28% and 0.09%, respectively. Among 50,061 ...
Tópico(s): Colorectal Cancer Screening and Detection
1995 - Oxford University Press | Japanese Journal of Cancer Research
Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Yoshiaki Inui, Hiroyuki Fukui, Taizo Hijioka, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Eijiro Hayashi, Michio Kato, Atsushi Hosui, Takuya Miyagi, Hisashi Ishida, Yuichi Yoshida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Norio Hayashi,
Tópico(s): Liver Disease Diagnosis and Treatment
2011 - Springer Science+Business Media | Journal of Gastroenterology
Tomohiro Hikata, Ken Ishii, Morio Matsumoto, Kazuyoshi Kobayashi, Shiro Imagama, Kei Ando, Naoki Ishiguro, Masaomi Yamashita, Shoji Seki, Hidetomi Terai, Akinobu Suzuki, Koji Tamai, Masaaki Aramomi, Tetsuhiro Ishikawa, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Kei Yamada, Michio Hongo, Kenji Endo, Hidekazu Suzuki, Atsushi Nakano, Kazuyuki Watanabe, Junichi Ohya, Hirotaka Chikuda, Yasuchika Aoki, Masayuki Shimizu, Toshimasa Futatsugi, Keijiro Mukaiyama, Masaichi Hasegawa, Katsuhito Kiyasu, Haku Iizuka, Ryoichi Kobayashi, Yoichi Iizuka, Kotaro Nishida, Kenichiro Kakutani, Hideaki Nakajima, Hideki Murakami, Satoru Demura, Satoshi Kato, Katsuhito Yoshioka, Takashi Namikawa, Kei Watanabe, Kazuyoshi Nakanishi, Yukihiro Nakagawa, Mitsunori Yoshimoto, Hiroyasu Fujiwara, Norihiro Nishida, Yasuaki Imajo, Masashi Yamazaki, Tetsuya Abe, Kengo Fujii, Takashi Kaito, Yawara Eguchi, Takeo Furuya, Sumihisa Orita, Seiji Ohtori,
Retrospective cohort study.To clarify the poor patient satisfaction after lumbar spinal surgery in elderly patients.As the global population continues to age, it is important to consider the surgical outcome and patient satisfaction in the elderly. No studies have assessed patient satisfaction in elderly patients undergoing surgical treatment and risk factors for poor satisfaction in elderly patients after lumbar spinal surgery.A retrospective multicenter survey was performed in 169 patients aged ...
Tópico(s): Scoliosis diagnosis and treatment
2020 - Lippincott Williams & Wilkins | Clinical Spine Surgery A Spine Publication
Yoshio Tsuda, Michio Haseyama, Keiichi Ishida, Jun Niizuma, Kyeong Soon Kim, Daiki YANAGI, Nozomi Watanabe, Mutsuo Kobayashi,
The Tsunami caused by the Great East Japan Earthquake on 11 March 2011 in north-eastern Japan destroyed urban and rural environments completely, including buildings, dwellings, roads, bridges, agricultural fields and natural vegetation. The after-effects of the Tsunami on the distribution and abundance of mosquitoes were studied in rice field areas in Miyagi Prefecture, Japan during June to August 2011. Adult mosquitoes were collected by traps enhanced with 1 kg dry ice and the density was compared ...
Tópico(s): Bird parasitology and diseases
2012 - Japan Society of Medical Entomology and Zoology | Medical Entomology and Zoology
Yasushi Takatsuki, Michio Aoyama, Toshiya Nakano, Haruo Miyagi, Toshihiro Ishihara, Toshiya Tsutsumida,
The comparison experiment results of the standard seawater (SSW) were presented for batches P90, P100, P104, P106, P108 P111, and P112. This work shows that the SSW batch-to-batch agreement was recently improved. The adjusted mean differences relative to the mean of SSW batches P91 to P102 (Mantyla 1987) ranged from −0.6×10−3 to 0.8×10−3 for the SSW batches of P100, P104, P106, P108, P111, and P112.
Tópico(s): Water Quality Monitoring and Analysis
1991 - American Meteorological Society | Journal of Atmospheric and Oceanic Technology