Michiru Akamatsu, Ryosuke Hirozumi, Yuko Cho, Yuta Kudo, Keiichi Konoki, Yasukatsu Oshima, Mari Yotsu‐Yamashita,
Saxitoxin and its analogues, paralytic shellfish toxins (PSTs), are potent and specific voltage-gated sodium channel blockers. These toxins are produced by some species of freshwater cyanobacteria and marine dinoflagellates. We previously identified several biosynthetic intermediates of PSTs, as well as new analogues, from such organisms and proposed the biosynthetic and metabolic pathways of PSTs. In this study, 12β-deoxygonyautoxin 5 (12α-gonyautoxinol 5 = gonyautoxin 5-12(R)-ol) was identified in ...
Tópico(s): Marine Sponges and Natural Products
2022 - Multidisciplinary Digital Publishing Institute | Marine Drugs