G.I. Robertson, D. G. Davey, N. Hamilton Fairley,
Background and aims Microbiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, ... for screening for CRC. Methods We profiled the microbiota in oral swabs, colonic mucosae and stool from ... s pp. A classification model of oral swab microbiota distinguished individuals with CRC or polyps from controls ( ... polyps); specificity: 96%). Combining the data from faecal microbiota and oral swab microbiota increased the sensitivity of this model to 76% ( ...
Tópico(s): Microscopic Colitis
1952 - BMJ | BMJ
National Library of Medicine (NCBI)
... Journal of Clinical Investigation, Vol. 133, No. 4Gut microbiota-derived metabolites and their importance in neurological disorders18 ... No. 4Mechanisms of Blood–Brain Barrier Protection by Microbiota-Derived Short-Chain Fatty Acids18 February 2023 | Cells, ... of short-chain fatty acid production by gut microbiota in neurodegenerative disordersNutrition Research, Vol. 106Obesity-Associated Neuropathy: ... MechanismsAntioxidants & Redox Signaling, Vol. 37, No. 7-9How Microbiota-Derived Metabolites Link the Gut to the Brain ...
Tópico(s): Advanced Chemical Sensor Technologies
1973 - American Physiological Society | American Journal of Physiology-Legacy Content
PubMed Central (PMC)
Kieran Tuohy, Christos Gougoulias, Qing Shen, Gemma E. Walton, Francesca Fava, Priya Ramnani,
The human gut microbiota comprises a diverse microbial consortium closely co-evolved with the human genome and diet. The importance of the gut microbiota in regulating human health and disease has however ... the intestinal habitat, the complexity of the gut microbiota itself and the fact that many of its ... laboratory culture, this limited view of the gut microbiota is rapidly changing. This review will discuss the ... molecular microbiological tools to study the human gut microbiota in a culture independent manner. Genomics or metagenomics ...
Tópico(s): Nutrition, Genetics, and Disease
2009 - Bentham Science Publishers | Current Pharmaceutical Design
Directory of Open Access Journals (DOAJ)
... diverse collection of commensal microorganisms known as the microbiota. In particular, 100 trillion bacteria of greater than ... Scopus (1758) Google Scholar). Colonization with a complex microbiota or even a unique single species of bacteria ... these studies are that defined members of the microbiota have evolved the unique ability to direct specific ... the extraordinary diversity and complexity of the intestinal microbiota, how can specific microbes with discrete biological functions ... of germ-free animals with a complex murine microbiota induced gene expression similar to conventionally raised mice, ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2009 - Cell Press | Immunity
Ester Vanni, Elisabetta Bugianesi,
... 1, zonula occludens-1. The concept that gut microbiota, i.e., the billions of bacteria resident within ... availability.1 It has been proposed that gut microbiota is able to promote steatohepatitis by enhancing hepatic ... a causative role of quantitative alterations of gut microbiota. However, in insulin-resistant states, hyperinsulinemia and high ... prevalence of diabetes were not reported. Recently, gut microbiota has been shown to affect fat storage and ... their data suggest a potential relationship between gut microbiota and clinical (MS) and histological (hepatic steatosis) evidence ...
Tópico(s): Liver Disease Diagnosis and Treatment
2009 - Lippincott Williams & Wilkins | Hepatology
Herbert Tilg, Alexander R. Moschen, Arthur Kaser,
... of germ-free mice with a normal gut microbiota harvested from the distal intestine of conventionally raised ... obesity, and insulin resistance, suggesting that the gut microbiota may affect energy absorption. In addition, development of ... the composition and metabolic function of the gut microbiota. This trait is even transmissible as colonization of germ-free mice with an “obese gut microbiota” results in a greater increase in total body fat than colonization with a “lean gut microbiota.” Recent studies in obese and lean twins suggest ...
Tópico(s): Dietary Effects on Health
2009 - Elsevier BV | Gastroenterology
Sampo J. Lahtinen, Robert Boyle, S. Kivivuori, Frances Oppedisano, Katherine R. Smith, Roy M. Robins‐Browne, Seppo Salminen, Mimi L.K. Tang,
... the Editor: Presence of an altered intestinal Bifidobacterium microbiota during infancy is associated with an increased risk ... prevent allergic disease by modifying the early intestinal microbiota. Administration of probiotics from the prenatal period through ... may also influence the development of infants' Bifidobacterium microbiota.7Gueimonde M. Sakata S. Kalliomäki M. Isolauri E. ... GG on transfer and establishment of fecal bifidobacterial microbiota in neonates.J Pediatr Gastroenterol Nutr. 2006; 42: ...
Tópico(s): Gut
2009 - Elsevier BV | Journal of Allergy and Clinical Immunology
Knut Rudi, Kristin Ødegård, Tine Therese Løkken, Robert C. Wilson,
The distribution pattern of the earthworm gut microbiota at the host population level is of fundamental importance to understand host-microbiota interactions. Our current understanding of these interactions is very limited. ... feeding represents a main perturbation of the gut microbiota, we determined the effect of a single dose of feed on the microbiota associated with an earthworm population in a simulated ... determined the overall composition of the earthworm-associated microbiota by 16S rRNA gene cloning and sequencing. Based ...
Tópico(s): Insect symbiosis and bacterial influences
2009 - Public Library of Science | PLoS ONE
... body’s assortment of microorganisms, collectively called the microbiota, is similar to an organ in that it ... an environmental agent alters the function of the microbiota, the result can be disease.Most environment–microbiota research has focused on the gut, home to ... and cancer. Some researchers even suspect that the microbiota may play a role in autism spectrum disorders ( ... of organisms. Although all humans have grossly similar microbiota, no two people have exactly the same composition ... recent advances in understanding the relationship between our microbiota and our health.Our Microbial PartnersThe infant GI ...
Tópico(s): Food Security and Health in Diverse Populations
2009 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Vidya Velagapudi, Rahil Hezaveh, Christopher S. Reigstad, Peddinti Gopalacharyulu, Laxman Yetukuri, Sama Islam, Jenny Felin, Rosie Perkins, Jan Borén, Matej Orešič, Fredrik Bäckhed,
The gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared ... acids were reduced. We also showed that the microbiota modified a number of lipid species in the ... lipid clearance. Our findings show that the gut microbiota affects both host energy and lipid metabolism and ... in the development of metabolic diseases. The gut microbiota has recently been identified as an environmental factor ...
Tópico(s): Dietary Effects on Health
2009 - Elsevier BV | Journal of Lipid Research
Michael E. Peterson, Robin A. Matthews,
... macroinvertebrates, whereas retention and transfer of nutrients by microbiota has received less attention. Our research objective was ... decomposing salmon tissue into periphyton, bryophytes, leaf-pack microbiota, and amphipods in laboratory mesocosm streams. We measured δ15N of microbiota growing on unglazed tiles (periphyton), microbiota growing on leaf packs, bryophytes on partially submerged ... amphipods; C:N and C:P ratios of microbiota and bryophytes; and periphyton biomass (ash-free dry ... decomposing salmon tissue. Periphyton, bryophytes, and leaf-pack microbiota had lower C:N ratios and leaf-pack ...
Tópico(s): Isotope Analysis in Ecology
2009 - University of Chicago Press | Journal of the North American Benthological Society
Denis Mariat, Olivier Firmesse, Florence Levenez, VD Guimarăes, Harry Sokol, Joël Doré, Gérard Corthier, J-P Furet,
In humans, the intestinal microbiota plays an important role in the maintenance of host health by providing energy, nutrients, and immunological protection. Applying current molecular ... order to obtain an accurate description of the microbiota composition.Here we report on the comparative assessment of human fecal microbiota from three age-groups: infants, adults and the elderly. We demonstrate that the human intestinal microbiota undergoes maturation from birth to adulthood and is ... observed age-related changes in the human fecal microbiota. The microbiota of infants was generally characterized by ...
Tópico(s): Gastrointestinal motility and disorders
2009 - BioMed Central | BMC Microbiology
Koen Venema, Marleen H.M.C. van Nuenen, Ellen G. H. M. van den Heuvel, Wietske Pool, J.M.B.M. van der Vossen,
... intestine. After an adaptation period of the faecal microbiota in the in vitro model of the proximal ... lactulose (10 g/day) was fed to the microbiota over a 48-h period. Samples taken from the model were investigated for microbiota composition and metabolite production (short-chain fatty acids ( ... lactulose. This was clear in the non-adapted microbiota by the observed arrest in butyrate production 24 ... start of lactulose feeding. However, in the adapted microbiota butyrate production was already low from the start ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2003 - Taylor & Francis | Microbial Ecology in Health and Disease
Tomáš Hrnčíř, Renata Štěpánková, Hana Kozáková, Tomáš Hudcovic, Helena Tlaskalová-Hogenová,
... is harbored by the distal intestine. The gut microbiota outnumber ~10 times the total number of our somatic and germ cells. The host-microbiota relationship has evolved to become mutually beneficial. Studies in germ-free mice have shown that gut microbiota play a crucial role in the development of ... was to elucidate whether the presence of gut microbiota and the quality of a sterile diet containing ... We have found that the presence of gut microbiota and to a lesser extent also the LPS- ... have observed that both the presence of gut microbiota and the LPS-rich sterile diet influence in ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2008 - BioMed Central | BMC Immunology
María Carmen Collado, Erika Isolauri, Kirsi Laitinen, Seppo Salminen,
... of experimental studies suggest that deviations in gut microbiota composition predispose to excessive energy storage and obesity. ... the original inoculum and the development of infant microbiota, which in turn is associated with later weight gain. Objective: We characterized the gut microbiota in women according to their body mass index ( ... weight gain over pregnancy on the composition of microbiota before delivery. Design: Overweight women (n = 18) were ... Institute of Medicine recommendations. The composition of gut microbiota was analyzed by fluorescent in situ hybridization coupled ...
Tópico(s): Diet and metabolism studies
2008 - Elsevier BV | American Journal of Clinical Nutrition
S. Ott, Tanja Kühbacher, Meike Musfeldt, Philip Rosenstiel, Stephan Hellmig, Ateequr Rehman, Oliver Drews, Wilko Weichert, Kenneth N. Timmis, Stefan Schreiber,
Altered bacterial diversity of the intestinal mucosa-associated microbiota may reflect the net influence of lifestyle factors ... in IBD, little is known about the fungal microbiota. The aim of this study was to carry out a systematic analysis of intestinal fungal microbiota in IBD.The mucosa-associated fungal microbiota of 104 colonic biopsy tissues from 47 controls ... for only a small proportion of the intestinal microbiota (0.02% of the mucosal and 0.03% of the fecal microbiota). An overall fungal biodiversity of 43 different operational ...
Tópico(s): Microscopic Colitis
2008 - Taylor & Francis | Scandinavian Journal of Gastroenterology
... 1.3. Host characteristics that affect the indigenous microbiota. 1.4. Techniques used to characterize the microbial ... interactions. 1.6. Further reading. 2. The indigenous microbiota of the skin . 2.1. Anatomy and physiology ... at different skin regions. 2.4. The indigenous microbiota of the skin. 2.5. Overview of the cutaneous microbiota. 2.6. Sources of data used to compile figures. 2.7. Further reading. 3 . The indigenous microbiota of the eye. 3.1. Anatomy and physiology ... on the conjunctival surface. 3.4. The indigenous microbiota of the eye. 3.5. Overview of the ...
Tópico(s): Gut
2008 - Association of College and Research Libraries | Choice Reviews Online
Volker Mai, Peter V. Draganov,
The complex gut microbial flora harbored by individuals (microbiota) has long been proposed to contribute to intestinal ... probiotic products aimed at improving health by modifying microbiota composition have already become widely available and acceptance ... However, although required for the development of effective microbiota based interventions, our basic understanding of microbiota variation on a population level and its dynamics ... parallel sequence technologies combined with other efficient molecular microbiota analysis methods now allow for comprehensive analysis of ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2008 - Baishideng Publishing Group | World Journal of Gastroenterology
Vincent B. Young, Robert A. Britton, Thomas M. Schmidt,
... used for the therapeutic manipulation of the indigenous microbiota. We were fortunate to receive a strong collection ... issue. In the first article “Conceptualizing the human microbiota: from multicelled organ to ecological community,” B. Foxman ... intestinal epithelium with the pathogen and the indigenous microbiota: a three way crosstalk,” by C. V. Srikanth ... the interactions between epithelial pathogens and the indigenous microbiota in the mammalian gut. In the fourth article “ ... exploring biodiversity and population dynamics of human intestinal microbiota: what can be revealed?” G. Huys et al. ...
Tópico(s): Probiotics and Fermented Foods
2008 - Hindawi Publishing Corporation | Interdisciplinary Perspectives on Infectious Diseases
Inna Sekirov, Nicola Tam, Maria Jogova, Marilyn L. Robertson, Yuling Li, Claudia Lupp, B. Brett Finlay,
ABSTRACT Intestinal microbiota comprises microbial communities that reside in the gastrointestinal tract and are critical to normal host physiology. Understanding the microbiota's role in host response to invading pathogens ... enteric pathogen to investigate the effect of intestinal microbiota perturbation on host susceptibility to infection. Antibiotics were used to perturb the intestinal microbiota. C57BL/6 mice were treated with clinically relevant ... infection with Salmonella enterica serovar Typhimurium. Alterations in microbiota composition and numbers were evaluated by fluorescent in ...
Tópico(s): Probiotics and Fermented Foods
2008 - American Society for Microbiology | Infection and Immunity
David You, M. Alaric Franzos, Robert P. Holman,
... Prevention of Infectious Disease and Health PromotionTrasplante de microbiota fecal en el tratamiento de colitis grave complicada ... en un paciente con síndrome de inmunodeficiencia adquiridaFecal microbiota transplantation for severe complicated C. difficile colitis in ... acquired immunodeficiency syndromeSafety and efficacy of encapsulated fecal microbiota transplantation for recurrent Clostridium difficile infection: a systematic ... Therapeutic use of Pre- and Probiotics and Fecal Microbiota TransplantationControl of Clostridium difficile Infection by Defined Microbial ...
Tópico(s): Gastrointestinal motility and disorders
2008 - American College of Physicians | Annals of Internal Medicine
Peter J. Turnbaugh, Jeffrey I. Gordon,
... organisms in a given physiological and environmental context.Microbiota: A microbial community, including Bacteria, Archaea, Eukarya, and ... collective genomes present in members of a given microbiota.Phylotype: A phylogenetic group of microbes, currently defined ... metabotypes).Seed bank: Low-abundance phylotypes within a microbiota that may not significantly alter major metabolic fluxes. ... organisms in a given physiological and environmental context. Microbiota: A microbial community, including Bacteria, Archaea, Eukarya, and ...
Tópico(s): Nutrition, Genetics, and Disease
2008 - Cell Press | Cell
Julia A. Bell, Jamie J. Kopper, Judy A. Turnbull, N Barbu, Alice J. Murphy, Linda S. Mansfield,
... analysis to assess (1) stability of the fecal microbiota in dogs living in environments characterized by varying ... of exposure to factors that might alter the microbiota and (2) changes in the microbiota associated with acute episodes of diarrhea. Results showed ... minimal exposure to factors that might alter the microbiota had similar microbiotas; the microbiotas of dogs kept ... environments were more variable. Substantial changes in the microbiota occurred during diarrheic episodes, including increased levels of ...
Tópico(s): Microscopic Colitis
2008 - Hindawi Publishing Corporation | Interdisciplinary Perspectives on Infectious Diseases
Gary B. Huffnagle, Mairi C. Noverr,
... 5-10 years. Likewise, scientific studies investigating the microbiota and the immune system have increased significantly in ... observations indicating that antibiotics and fungi can skew microbiota composition and systemic immune responses. Our initial baseof ... develop further hypotheses concerning the mechanisms involved in microbiota regulation of immune responses was limited. However, in ... dedicated to current trends in investigating the GI microbiota was warranted. Dissection of the relationship between the ...
Tópico(s): Gut
2008 - Springer Nature | Advances in experimental medicine and biology
Seppo Salminen, Erika Isolauri,
... vaginal tract and skin. The origin of the microbiota and its development depend on genetics, mode of ... the hygienic conditions around the child. The indigenous microbiota of an infant's gastrointestinal tract is modulated through contact and interaction with the microbiota of the parents and the infant's immediate ... the mother's skin enabling the infant gut microbiota to be dominated by bifidobacteria. These bacteria set ... for the development of the infant's gut microbiota may form a beneficial possibility for future infant ...
Tópico(s): Infant Health and Development
2008 - Karger Publishers | Nestlé Nutrition Workshop series. Pediatric program/Nestlé Nutrition Workshop series. Paediatric program
Marie France De La Cochetiere, Tony Durand, V. Lalande, Jean‐Claude Petit, G. Potel, Laurent Beaugerie,
... Recent studies have shown that the human fecal microbiota is composed of a consortium of microorganism. It is known that antibiotic treatment alters the microbiota, facilitating the proliferation of opportunists that may occupy ... them. It is therefore important to characterize resident microbiota to evaluate its latent ability to permit the ... the possible relationship between the fecal dominant resident microbiota and the subsequent development of C. difficile. We ... similarity (Pearson correlation coefficient). The characteristics of the microbiota were determined using PLS discriminant analysis model. Eighty- ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2008 - Springer Science+Business Media | Microbial Ecology