Miguel A. L. Nicolelis, Rick C.S. Lin, John K. Chapin,
Nicolelis, Miguel A. L., Rick C. S. Lin, and John K. Chapin. Neonatal whisker removal reduces the discrimination ...
Tópico(s): Tactile and Sensory Interactions
1997 - American Physiological Society | Journal of Neurophysiology
Produção Nacional
Revisado por pares
Sidarta Ribeiro, Sidarta Ribeiro, Xinwu Shi, Matthew Engelhard, Yi Zhou, Hao Zhang, Damien Gervasoni, Shih‐Chieh Lin, Kazuhiro Wada, Nelson A.M Lemos, Nelson A.M Lemos, Miguel A. L. Nicolelis, Miguel A. L. Nicolelis, Miguel A. L. Nicolelis,
Episodic and spatial memories engage the hippocampus during acquisition but migrate to the cerebral cortex over time. We have recently proposed that the interplay between slow-wave (SWS) and rapid eye movement (REM) sleep propagates recent synaptic changes from the hippocampus to the cortex. To test this theory, we jointly assessed extracellular neuronal activity, local field potentials (LFP), and expression levels of plasticity-related immediate-early genes (IEG) arc and zif-268 in rats exposed to ...
Tópico(s): Neural dynamics and brain function
2007 - Frontiers Media | Frontiers in Neuroscience
Eduardo D. Gomes, Nuno A. Silva, António J. Salgado,
... Asboth et al., 2018). On the other hand, Miguel Nicolelis' group has paved the way of BMI applications, ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2018 - Medknow | Neural Regeneration Research
Liz Stillwaggon Swan, Louis J. Goldberg,
... foundation of meaning-making in organisms. We employ Miguel Nicolelis et al’s seminal research on the mammalian ...
Tópico(s): Origins and Evolution of Life
2010 - Springer Nature | Biosemiotics
... recorded from a monkey's motor cortex in Miguel Nicolelis's lab at Duke University, and the kinematic ...
Tópico(s): Modular Robots and Swarm Intelligence
2008 - | HFSP journal
... BMI) that might arise from the research of Miguel Nicolelis and Rodolfo Llinas. Stage 2 enhancement technologies undermine ...
Tópico(s): Neuroscience and Neural Engineering
2008 - Springer Nature (Netherlands) | Philosophy and medicine
... from David Kleinfeld (University of California San Diego), Miguel Nicolelis (Duke University), and Jonathan Rubin (University of Pittsburgh). ...
Tópico(s): Neuroscience and Neural Engineering
2003 - Taylor & Francis | Somatosensory & Motor Research
Asif A. Ghazanfar, Miguel A. L. Nicolelis,
Ghazanfar, Asif A. and Miguel A. L. Nicolelis. Nonlinear processing of tactile information in the thalamocortical loop. J. Neurophysiol. 78: 506–510, 1997. Rats explore tangible objects in ...
Tópico(s): Neuroscience and Neural Engineering
1997 - American Physiological Society | Journal of Neurophysiology
... No. 1The Relativistic Brain by Ronald Cicurel and Miguel L. Nicolelis (2015)Roman R. Poznanski3 November 2015 | Journal of ...
Tópico(s): Advanced Memory and Neural Computing
2004 - Imperial College Press | Journal of Integrative Neuroscience
Brazilian neuroscientist Miguel Nicolelis defends his plans to show off a thought-directed exoskeleton at the World Cup.
Tópico(s): Biomedical and Engineering Education
2014 - American Association for the Advancement of Science | Science
... the PDF of the “monkey-robot” article by Miguel Nicolelis received tens of thousands of downloads. We are ...
Tópico(s): Photoreceptor and optogenetics research
2004 - Public Library of Science | PLoS Biology
Produção Nacional
Revisado por pares
Miguel A. L. Nicolelis, Rafael L. G. Raimundo, Pedro S. Peixoto, Cecilia S. Andreazzi,
Although international airports served as main entry points for SARS-CoV-2, the factors driving the uneven geographic spread of COVID-19 cases and deaths in Brazil remain mostly unknown. Here we show that three major factors influenced the early macro-geographical dynamics of COVID-19 in Brazil. Mathematical modeling revealed that the "super-spreading city" of São Paulo initially accounted for more than 85% of the case spread in the entire country. By adding only 16 other spreading cities, we accounted ...
Tópico(s): COVID-19 impact on air quality
2021 - Nature Portfolio | Scientific Reports
Gordon Cheng, Stefan K. Ehrlich, Mikhail Lebedev, Miguel A. L. Nicolelis,
Advances in neuroscience are inspiring developments in robotics and vice versa.
Tópico(s): Advanced Memory and Neural Computing
2020 - American Association for the Advancement of Science | Science Robotics
Amol P. Yadav, Daniel Li, Miguel A. L. Nicolelis,
Abstract Lack of sensory feedback is a major obstacle in the rapid absorption of prosthetic devices by the brain. While electrical stimulation of cortical and subcortical structures provides unique means to deliver sensory information to higher brain structures, these approaches require highly invasive surgery and are dependent on accurate targeting of brain structures. Here, we propose a semi-invasive method, Dorsal Column Stimulation (DCS) as a tool for transferring sensory information to the brain. ...
Tópico(s): Neural dynamics and brain function
2020 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Aurelie Selfslagh, Solaiman Shokur, Debora S. F. Campos, Ana R. C. Donati, Sabrina Almeida, Seidi Y. Yamauti, Daniel Boari Coelho, Mohamed Bouri, Miguel A. L. Nicolelis,
Abstract Spinal cord injury (SCI) impairs the flow of sensory and motor signals between the brain and the areas of the body located below the lesion level. Here, we describe a neurorehabilitation setup combining several approaches that were shown to have a positive effect in patients with SCI: gait training by means of non-invasive, surface functional electrical stimulation (sFES) of the lower-limbs, proprioceptive and tactile feedback, balance control through overground walking and cue-based decoding ...
Tópico(s): Neuroscience and Neural Engineering
2019 - Nature Portfolio | Scientific Reports
Mikhail Lebedev, Alexei Ossadtchi, Nil Adell Mill, Núria Armengol Urpí, Maria R. Cervera, Miguel A. L. Nicolelis,
Abstract Back in 2012, Churchland and his colleagues proposed that “rotational dynamics”, uncovered through linear transformations of multidimensional neuronal data, represent a fundamental type of neuronal population processing in a variety of organisms, from the isolated leech central nervous system to the primate motor cortex. Here, we evaluated this claim using Churchland’s own data and simple simulations of neuronal responses. We observed that rotational patterns occurred in neuronal populations ...
Tópico(s): EEG and Brain-Computer Interfaces
2019 - Nature Portfolio | Scientific Reports
Po-He Tseng, Núria Armengol Urpí, Mikhail Lebedev, Miguel A. L. Nicolelis,
Although many real-time neural decoding algorithms have been proposed for brain-machine interface (BMI) applications over the years, an optimal, consensual approach remains elusive. Recent advances in deep learning algorithms provide new opportunities for improving the design of BMI decoders, including the use of recurrent artificial neural networks to decode neuronal ensemble activity in real time. Here, we developed a long-short term memory (LSTM) decoder for extracting movement kinematics from ...
Tópico(s): Neuroscience and Neural Engineering
2019 - The MIT Press | Neural Computation
Joseph E. O’Doherty, Solaiman Shokur, Leonel E. Medina, Mikhail Lebedev, Miguel A. L. Nicolelis,
Significance Sensory neuroprostheses offer the promise of restoring perceptual function to people with impaired sensation. Here, we developed a paradigm using intracortical microstimulation (ICMS) for encoding the sensation of fingertip motion against texture. Monkeys learned to interpret time-varying ICMS patterns, evoked by the interplay of their voluntary movements and specific object textures, and discriminated texture coarseness relying solely on these pulse trains. As such, variations in exploration ...
Tópico(s): Tactile and Sensory Interactions
2019 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Allen Yin, Po-He Tseng, Sankaranarayani Rajangam, Mikhail Lebedev, Miguel A. L. Nicolelis,
Abstract Primary motor (M1), primary somatosensory (S1) and dorsal premotor (PMd) cortical areas of rhesus monkeys previously have been associated only with sensorimotor control of limb movements. Here we show that a significant number of neurons in these areas also represent body position and orientation in space. Two rhesus monkeys (K and M) used a wheelchair controlled by a brain-machine interface (BMI) to navigate in a room. During this whole-body navigation, the discharge rates of M1, S1, and PMd ...
Tópico(s): Neural dynamics and brain function
2018 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Solaiman Shokur, Ana R. C. Donati, Debora S. F. Campos, Claudia M. Gitti, Guillaume Bao, Dora Fischer, Sabrina Almeida, Vania A. S. Braga, Patricia B. Augusto, Chris Petty, Eduardo Joaquim Lopes Alho, Mikhail Lebedev, Allen W. Song, Miguel A. L. Nicolelis,
Spinal cord injury (SCI) induces severe deficiencies in sensory-motor and autonomic functions and has a significant negative impact on patients' quality of life. There is currently no systematic rehabilitation technique assuring recovery of the neurological impairments caused by a complete SCI. Here, we report significant clinical improvement in a group of seven chronic SCI patients (six AIS A, one AIS B) following a 28-month, multi-step protocol that combined training with non-invasive brain-machine ...
Tópico(s): Muscle activation and electromyography studies
2018 - Public Library of Science | PLoS ONE
Po-He Tseng, Sankaranarayani Rajangam, Gary Lehew, Mikhail Lebedev, Miguel A. L. Nicolelis,
While it is well known that the primate brain evolved to cope with complex social contingencies, the neurophysiological manifestation of social interactions in primates is not well understood. Here, concurrent wireless neuronal ensemble recordings from pairs of monkeys were conducted to measure interbrain cortical synchronization (ICS) during a whole-body navigation task that involved continuous social interaction of two monkeys. One monkey, the passenger, was carried in a robotic wheelchair to a ...
Tópico(s): Embodied and Extended Cognition
2018 - Nature Portfolio | Scientific Reports
Arjun Ramakrishnan, Yoon Woo Byun, Kyle Rand, Christian E. Pedersen, Mikhail Lebedev, Miguel A. L. Nicolelis,
Significance The ability to learn highly skilled movements may depend on the dopamine-related plasticity occurring in motor cortex, because the density of dopamine receptors—the reward sensor—increases in this area from rodents to primates. We hypothesized that primary motor (M1) and somatosensory (S1) neurons would encode rewards during operant conditioned motor behaviors. Rhesus monkeys were implanted with cortical multielectrode implants and trained to perform arm-reaching tasks with different ...
Tópico(s): Neuroscience and Neural Engineering
2017 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Amol P. Yadav, Miguel A. L. Nicolelis,
Spinal cord stimulation has been used for the treatment of chronic pain for decades. In 2009, our laboratory proposed, based on studies in rodents, that electrical stimulation of the dorsal columns of the spinal cord could become an effective treatment for motor symptoms associated with Parkinson's disease (PD). Since our initial report in rodents and a more recent study in primates, several clinical studies have now described beneficial effects of dorsal column stimulation in parkinsonian patients. ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2017 - Wiley | Movement Disorders
Tristan Vouga, Katie Zhuang, Jérémy Olivier, Mikhail Lebedev, Miguel A. L. Nicolelis, Mohamed Bouri, Hannes Bleuler,
Recent advances in the field of brain-machine interfaces (BMIs) have demonstrated enormous potential to shape the future of rehabilitation and prosthetic devices. Here, a lower-limb exoskeleton controlled by the intracortical activity of an awake behaving rhesus macaque is presented as a proof-of-concept for a locomotorBMI. A detailed description of the mechanical device, including its innovative features and first experimental results, is provided. During operation, BMI-decoded position and velocity ...
Tópico(s): Muscle activation and electromyography studies
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Neural Systems and Rehabilitation Engineering
Mikhail Lebedev, Miguel A. L. Nicolelis,
Brain-machine interfaces (BMIs) combine methods, approaches, and concepts derived from neurophysiology, computer science, and engineering in an effort to establish real-time bidirectional links between living brains and artificial actuators. Although theoretical propositions and some proof of concept experiments on directly linking the brains with machines date back to the early 1960s, BMI research only took off in earnest at the end of the 1990s, when this approach became intimately linked to new ...
Tópico(s): Muscle activation and electromyography studies
2017 - American Physiological Society | Physiological Reviews
Produção Nacional
Revisado por pares
Ana R. C. Donati, Solaiman Shokur, Edgard Morya, Debora S. F. Campos, Renan C. Moioli, Claudia M. Gitti, Patricia B. Augusto, Sandra Tripodi, Cristhiane Garabello Pires, Gislaine A. Pereira, Fabrício Lima Brasil, Simone Gallo, Anthony A. Lin, A. Takigami, Maria Adelia Aratanha, Sanjay S. Joshi, Hannes Bleuler, Gordon Cheng, Alan Rudolph, Miguel A. L. Nicolelis,
Brain-machine interfaces (BMIs) provide a new assistive strategy aimed at restoring mobility in severely paralyzed patients. Yet, no study in animals or in human subjects has indicated that long-term BMI training could induce any type of clinical recovery. Eight chronic (3-13 years) spinal cord injury (SCI) paraplegics were subjected to long-term training (12 months) with a multi-stage BMI-based gait neurorehabilitation paradigm aimed at restoring locomotion. This paradigm combined intense immersive ...
Tópico(s): Neuroscience and Neural Engineering
2016 - Nature Portfolio | Scientific Reports
Solaiman Shokur, Simone Gallo, Renan C. Moioli, Ana R. C. Donati, Edgard Morya, Hannes Bleuler, Miguel A. L. Nicolelis,
Abstract Spinal cord injuries disrupt bidirectional communication between the patient’s brain and body. Here, we demonstrate a new approach for reproducing lower limb somatosensory feedback in paraplegics by remapping missing leg/foot tactile sensations onto the skin of patients’ forearms. A portable haptic display was tested in eight patients in a setup where the lower limbs were simulated using immersive virtual reality (VR). For six out of eight patients, the haptic display induced the realistic ...
Tópico(s): Stroke Rehabilitation and Recovery
2016 - Nature Portfolio | Scientific Reports
Konstantin Hartmann, Eric E. Thomson, Ivan Zea, Richy Yun, Peter Mullen, Jay Canarick, Albert Huh, Miguel A. L. Nicolelis,
Can the adult brain assimilate a novel, topographically organized, sensory modality into its perceptual repertoire? To test this, we implemented a microstimulation-based neuroprosthesis that rats used to discriminate among infrared (IR) light sources. This system continuously relayed information from four IR sensors that were distributed to provide a panoramic view of IR sources, into primary somatosensory cortex (S1). Rats learned to discriminate the location of IR sources in <4 d. Animals in which ...
Tópico(s): Neuroscience and Neural Engineering
2016 - Society for Neuroscience | Journal of Neuroscience
Sankaranarayani Rajangam, Po-He Tseng, Allen Yin, Gary Lehew, David Schwarz, Mikhail Lebedev, Miguel A. L. Nicolelis,
Abstract Several groups have developed brain-machine-interfaces (BMIs) that allow primates to use cortical activity to control artificial limbs. Yet, it remains unknown whether cortical ensembles could represent the kinematics of whole-body navigation and be used to operate a BMI that moves a wheelchair continuously in space. Here we show that rhesus monkeys can learn to navigate a robotic wheelchair, using their cortical activity as the main control signal. Two monkeys were chronically implanted ...
Tópico(s): Gaze Tracking and Assistive Technology
2016 - Nature Portfolio | Scientific Reports
Miguel Pais-Vieira, Amol P. Yadav, Derek Moreira, David J. Guggenmos, Amílcar Silva‐dos‐Santos, Mikhail Lebedev, Miguel A. L. Nicolelis,
Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal ...
Tópico(s): Neuroscience and Neural Engineering
2016 - Nature Portfolio | Scientific Reports