Book.
1985 - Gale Group | World Scholar Latin America
María C. Ochoa, Elisabeth Pérez-Ruíz, Luna Minute, Carmen Oñate, Guiomar Pérez, Inmaculada Rodríguez, Aintzane Zabaleta, Diego Alignani, Myriam Fernandez-Sendín, Ascensión López, Aura Muntasell, Miguel F. Sanmamed, Bruno Paiva, Miguel López‐Botet, Pedro Berraondo, Ignacio Melero,
Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attached daratumumab and when encountering a daratumumab-coated CD38+ tumor cell line. In this setting, addition of the agonist anti-CD137 mAb urelumab enhances NK-cell activation increasing CD25 expression ...
Tópico(s): T-cell and B-cell Immunology
2019 - Landes Bioscience | OncoImmunology
Nuno Macedo, Alcino Cunha, José Pereira, Renato Carvalho, Ricardo Silva, Ana C. R. Paiva, Miguel Sozinho Ramalho, Daniel Silva,
This paper presents Alloy4Fun, a web application that enables online editing and sharing of Alloy models and instances (including dynamic ones developed with the Electrum extension), to be used mainly in an educational context. By introducing secret paragraphs and commands in the models, Alloy4Fun allows the distribution and automated assessment of simple specification challenges, a mechanism that enables students to learn the language at their own pace. Alloy4Fun stores all versions of shared and ...
Tópico(s): Software Testing and Debugging Techniques
2021 - Elsevier BV | Science of Computer Programming
Susana Vives, David Martínez‐Cuadrón, Juan Bergua, Lorenzo Algarra, Mar Tormo, María Pilar Martínez‐Sánchez, Josefina Serrano, Pilar Herrera, Fernando Ramos, Olga Salamero, Esperanza Lavilla, José Luis López Lorenzo, Cristina Gil, María‐Belén Vidriales, José Falantes, Alfons Serrano, Jorge Labrador, María J. Sayas, María Ángeles Foncillas, María L. Amador Barciela, María Teresa Olave, Mercedes Colorado, Adriana Gascón, Ángeles Fernández, Adriana Simiele, Manuel Pérez‐Encinas, Rebeca Rodríguez‐Veiga, Olga García, Joaquin Martínez‐López, Eva Barragán, Bruno Paiva, Miguel Á. Sanz, Pau Montesinos,
BACKGROUND Options to treat elderly patients (≥65 years old) newly diagnosed with acute myeloid leukemia (AML) include intensive and attenuated chemotherapy, hypomethylating agents with or without venetoclax, and supportive care. This multicenter, randomized, open‐label, phase 3 trial was designed to assess the efficacy and safety of a fludarabine, cytarabine, and filgrastim (FLUGA) regimen in comparison with azacitidine (AZA). METHODS Patients (n = 283) were randomized 1:1 to FLUGA (n = 141) or AZA (n = 142). ...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2021 - Wiley | Cancer
Produção Nacional
Revisado por pares
Mark Lenz, Yasser A. Ahmed, João Canning‐Clode, Eliecer Díaz, Sandra Eichhorn, Armin G. Fabritzek, Bernardo A.P. da Gama, M. Helena García, K. v. Juterzenka, Patrik Kraufvelin, Susanne Machura, Lisa Oberschelp, Filipa Paiva, Miguel A. Penna, Felipe V. Ribeiro, Martín Thiel, Daniel Wohlgemuth, Neviaty Putri Zamani, Martin Wahl,
Tópico(s): Aquatic Invertebrate Ecology and Behavior
2018 - Springer Science+Business Media | Biological Invasions
Nicolás Martínez‐Calle, Paula Rodríguez‐Otero, Sara Villar, Luis D. Mejías, Ignacio Melero, Felipe Prósper, Patricia Marinello, Bruno Paiva, Miguel Á. Idoate, Jesús F. San Miguel,
Tópico(s): Lymphoma Diagnosis and Treatment
2018 - Ferrata Storti Foundation | Haematologica
Rodrigo Martins Moreira, Ana C. R. Paiva, Miguel Nabuco, Atif M. Memon,
Summary Software systems with a graphical user interface (GUI) front end are typically designed using user interface (UI) Patterns, which describe generic solutions (with multiple possible implementations) for recurrent GUI design problems. However, existing testing techniques do not take advantage of this fact to test GUIs more efficiently. In this paper, we present a new pattern‐based GUI testing (PBGT) approach that formalizes the notion of UI Test Patterns, which are generic test strategies to test ...
Tópico(s): Software Reliability and Analysis Research
2017 - Wiley | Software Testing Verification and Reliability
Produção Nacional
Revisado por pares
Aureliano S. S. Paiva, Miguel Angel Rivera Castro, Roberto F. S. Andrade,
Here we investigate the inter-influence of oil prices and renewable energy sources. The non-stationary time series are scrutinized within the Detrended Cross-Correlation Analysis (DCCA) framework, where the resulting DCCA coefficient provides a useful and reliable index to the evaluate the cross correlation between events at the same time instant as well as at a suitably chosen time lags. The analysis is based on the quotient of two successive daily closing oil prices and composite indices of renewable ...
Tópico(s): Sustainability and Ecological Systems Analysis
2017 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Maria José Ribeiro, Joana S. Paiva, Miguel Castelo‐Branco,
When engaged in a repetitive task our performance fluctuates from trial-to-trial. In particular, inter-trial reaction time variability has been the subject of considerable research. It has been claimed to be a strong biomarker of attention deficits, increases with frontal dysfunction, and predicts age-related cognitive decline. Thus, rather than being just a consequence of noise in the system, it appears to be under the control of a mechanism that breaks down under certain pathological conditions. ...
Tópico(s): Neural and Behavioral Psychology Studies
2016 - Frontiers Media | Frontiers in Human Neuroscience
Raquel Ferreira, M. C. Fonseca, Tiago Santos, João Sargento‐Freitas, Ricardo Tjeng, Fernando Fernandes Paiva, Miguel Castelo‐Branco, Lino Ferreira, Liliana Bernardino,
Stroke is one of the leading causes of death and disability worldwide. However, current therapies only reach a small percentage of patients and may cause serious side effects. We propose the therapeutic use of retinoic acid-loaded nanoparticles (RA-NP) to safely and efficiently repair the ischaemic brain by creating a favourable pro-angiogenic environment that enhances neurogenesis and neuronal restitution. Our data showed that RA-NP enhanced endothelial cell proliferation and tubule network formation ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2016 - Royal Society of Chemistry | Nanoscale
Andreia Palmeira, M. Helena Vasconcelos, Ana M. Oliveira Paiva, Miguel X. Fernandes, Madalena Pinto, Emı́lia Sousa,
For many pathologies, there is a crescent effort to design multiple ligands that interact with a wide variety of targets. 1-Aminated thioxanthone derivatives were synthesized and assayed for their in vitro dual activity as antitumor agents and P-glycoprotein (P-gp) inhibitors. The approach was based on molecular hybridization of a thioxanthone scaffold, present in known antitumor drugs, and an amine, described as an important pharmacophoric feature for P-gp inhibition. A rational approach using homology ...
Tópico(s): Natural product bioactivities and synthesis
2011 - Elsevier BV | Biochemical Pharmacology
Fabio Silvio Taccone, Anne‐Marie Van den Abeele, Pierre Bulpa, Benoît Misset, Wouter Meersseman, Teresa Cardoso, José Artur Paiva, Miguel Ángel Blasco-Navalpotro, Emmanuel De Laere, George Dimοpoulos, Jordi Rello, Dirk Vogelaers, Stijn Blot,
Abstract Introduction Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated a high incidence of IA in intensive care unit (ICU) patients. However, few data are available on the epidemiology and outcome of patients with IA in this setting. Methods An observational study including all patients with a positive Aspergillus culture during ICU stay was performed in 30 ICUs in 8 countries. Cases were classified as proven ...
Tópico(s): Nosocomial Infections in ICU
2015 - BioMed Central | Critical Care
Produção Nacional
Revisado por pares
Luciana Paiva, Miguel Ângelo Marini,
We studied the Lesser Elaenia (Elaenia chiriquensis) to understand temporal patterns of occurrence and breeding of an intratropical migrant in a highly seasonal savanna (Cerrado). We tested the hypotheses that: (1) occurrence of the Lesser Elaenia in breeding areas is long, as expected for a migrant breeding in the Neotropics, and (2) the breeding period is also lengthy, as the breeding window increases in tropical latitudes. We recorded the abundance of individuals (n = 5,603 records) and nests (n = 502) ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2013 - Wilson Ornithological Society | The Wilson Journal of Ornithology
Mara Ventura, Leonor Gomes, Joana Rosmaninho‐Salgado, Luísa Barros, Isabel Paiva, Miguel Melo, Diana Oliveira, Francisco Carrilho,
Summary Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11.2 microdeletion. His initial complaints were related to obesity, loss of facial hair and polydipsia. He also had a history of social-interaction difficulties during childhood. His blood tests were consistent with hypogonadotropic hypogonadism and secondary ...
Tópico(s): Neuroblastoma Research and Treatments
2019 - Wiley | Endocrinology Diabetes and Metabolism Case Reports
Produção Nacional
Revisado por pares
João Batista de Paiva, Miguel Ferragut Attizzani, Hiroshi Miasiro Júnior, José Rino Neto,
Facial harmony is one of the main goals of orthodontic treatment, and it is not always correlated with the attainment of cephalometric objectives. The purpose of this study was to evaluate two groups of subjects presenting a clinically balanced soft tissue profile using cephalometric radiographs. Thirty lateral cephalometric radiographs of white females, divided in two groups, one with excellent facial profile (Group 1), and the other with good facial profile (Group 2) were used. Student's t-test ( ...
Tópico(s): Temporomandibular Joint Disorders
2010 - Brazilian Society of Dental Research | Brazilian Oral Research
Paiva Miguel, Zanetti Joanna, Zanetti Stefano, Stieben Alejandro, Tidball Eduardo,
Polymer flooding, a high viscosity solution of water and polymer, is introduced as an enhancement of oil recovery methods which is pumped through injector wells to push the liquid hydrocarbon towards production wells. Nowadays, the polymer injections method through layers for different flow admissions has allowed the improvement of heterogeneous flow distribution and the oil recovery factor itself. However, choke valves are needed to get the flow control in admission layers. Nevertheless, any flow ...
Tópico(s): Reservoir Engineering and Simulation Methods
2021 - Elsevier BV | Journal of Petroleum Science and Engineering
Natália António, Ana da Rosa Soares, Tiago Carvalheiro, Rosa Fernandes, Artur Paiva, Miguel Ventura, João Cristóvão, Luís Elvas, Lino Gonçalves, Luís A. Providência, Carlos Ribeiro, Guilherme Mariano Pêgo,
Background It would be important to better identify heart failure (HF) patients most likely to respond to cardiac resynchronization therapy (CRT). Because endothelial progenitor cells (EPCs) play a crucial role in the maintenance of vascular endothelium integrity, we hypothesize that patients who have higher circulating EPCs levels have greater neovascularization potential and are more prone to be responders to CRT. Methods Prospective study of 30 consecutive patients, scheduled for CRT. Echocardiographic ...
Tópico(s): Pulmonary Hypertension Research and Treatments
2014 - Wiley | Pacing and Clinical Electrophysiology
David Martínez Ramos, Jomine Jose, Javier Escrig Sos, G. Paiva Coronel, Miguel Alcalde Sánchez, José Sanchís,
Introduction: controversy remains about the management of gallstone ileus.While some authors propose enterotomy, others defend the one-stage procedure (simultaneously fistula repair).The objective of the present study was to analyze management options and comparative study their results.Material and methods: retrospective and descriptive study with revision of clinical stories of patients with the diagnosis of gallstone ileus between 1987 and 2008.All the following variables were recorded: dates ...
Tópico(s): Gastrointestinal disorders and treatments
2009 - Arán Ediciones | Revista Española de Enfermedades Digestivas
Produção Nacional
Revisado por pares
Herdjânia Veras de Lima, Cláudia Liane Rodrigues de Lima, Tairone Paiva Leão, Miguel Cooper, Álvaro Pires da Silva, Ricardo Espíndola Romero,
O estudo micromorfológico permite observar detalhadamente todas as modificações causadas na estrutura e no espaço poroso do solo, impostas pelo cultivo e pelo tráfego de máquinas agrícolas. Este trabalho testou a hipótese de que a compactação causada pelo tráfego de máquinas influi, diferencialmente, na forma e na distribuição das classes de poros, os quais podem ser utilizados como indicadores da qualidade do solo. O objetivo deste trabalho foi avaliar e quantificar, por meio de estudos micromorfológicos, ...
Tópico(s): Crop Yield and Soil Fertility
2005 - Sociedade Brasileira de Ciência do Solo | Revista Brasileira de Ciência do Solo
Marta Larráyoz, María J. García‐Barchino, Jon Celay, Amaia Etxebeste, Maddalen Jiménez, Cristina Pérez, Raquel Ordóñez, César Cobaleda, Cirino Botta, Vicente Fresquet, Sergio Roa, Ibai Goicoechea, Catarina Maia, Miren Lasaga, Marta Chesi, P. Leif Bergsagel, María‐José Larráyoz, Marı́a José Calasanz, Elena Campos-Sánchez, Jorge Martínez-Cano, Carlos Panizo, Paula Rodríguez‐Otero, Silvestre Vicent, Giovanna Roncador, Patricia González, Satoru Takahashi, Samuel G. Katz, Loren D. Walensky, Shannon M. Ruppert, Elisabeth A. Lasater, Maria Amann, Teresa Lozano, Diana Llópiz, Pablo Sarobe, Juan José Lasarte, Núria Planell, David Gómez-Cabrero, Olga Kudryashova, Anna Kurilovich, María V. Revuelta, Leandro Cerchietti, Xabier Agirre, Jesús F. San Miguel, Bruno Paiva, Felipe Prósper, José A. Martínez-Climent,
Abstract The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-κB, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. Fifteen genetically diverse models developed bone marrow (BM) tumors fulfilling MM pathogenesis. Integrative analyses ...
Tópico(s): Protein Degradation and Inhibitors
2023 - Nature Portfolio | Nature Medicine
Raul G. Nogueira, Muhammad M. Qureshi, Mohamad Abdalkader, Sheila Cristina Ouriques Martins, Hiroshi Yamagami, Zhongming Qiu, Malek Mansour, Anvitha Sathya, Anna Członkowska, Georgios Tsivgoulis, Diana Aguiar de Sousa, Jelle Demeestere, Robert Mikulík, Peter Vanacker, James E. Siegler, Janika Kõrv, José Biller, Conrad W Liang, Navdeep Sangha, Alicia Zha, Alexandra L. Czap, Christine A Holmstedt, Tanya N. Turan, George Ntaios, Konark Malhotra, Ashis Tayal, Aaron Loochtan, Annemarei Ranta, Eva Mistry, Anne W. Alexandrov, David Huang, Shadi Yaghi, Eytan Raz, Sunil A. Sheth, Mahmoud Mohammaden, Michael Frankel, Eric Guemekane Bila Lamou, Hany Aref, Ahmed Elbassiouny, Farouk Hassan, Tarek Menecie, Wessam Mustafa, Hossam Shokri, Tamer Roushdy, Fred Stephen Sarfo, Tolulope Oyetunde Alabi, Babawale Arabambi, Ernest Nwazor, Taofiki Sunmonu, Kolawole Wahab, Joseph Yaria, Haytham Hussein Mohammed, Philip Adebayo, A. Riahi, Samia Ben Sassi, Lenon Gwaunza, Gift Ngwende, David Sahakyan, Aminur Rahman, Zhibing Ai, Fanghui Bai, Zhenhui Duan, Yonggang Hao, Wenguo Huang, Guangwen Li, Wei Li, Ganzhe Liu, Jun Luo, Xianjin Shang, Yi Sui, Ling Tian, Hao Wen, Bo Wu, Yuying Yan, Zhengzhou Yuan, Hao Zhang, Jun Zhang, Wenlong Zhao, Wenjie Zi, Thomas Leung, Chandril Chugh, Vikram Huded, Bindu Menon, Jeyaraj Pandian, PN Sylaja, Fritz Sumantri Usman, Mehdi Farhoudi, Elyar Sadeghi‐Hokmabadi, Anat Horev, Anna Reznik, Rotem Sivan Hoffmann, Nobuyuki Ohara, Nobuyuki Sakai, Daisuke Watanabe, Ryoo Yamamoto, Ryosuke Doijiri, Naoki Tokuda, Takehiro Yamada, Tadashi Terasaki, Yukako Yazawa, Takeshi Uwatoko, Tomohisa Dembo, Hisao Shimizu, Yuri Sugiura, Fumio Miyashita, Hiroki Fukuda, Kosuke Miyake, Junsuke Shimbo, Yusuke Sugimura, Yoshiki Yagita, Yohei Takenobu, Yuji Matsumaru, Satoshi Yamada, Ryuhei Kono, Takuya Kanamaru, Hidekazu Yamazaki, Manabu Sakaguchi, Kenichi Todo, Nobuaki Yamamoto, Kazutaka Sonoda, Tomoko Yoshida, Hiroyuki Hashimoto, Ichiro NAKAHARA, Аida Kondybayeva, Kamila Faizullina, Saltanat Kamenova, Murat Zhanuzakov, Jang‐Hyun Baek, Yang‐Ha Hwang, Jin Soo Lee, Si Baek Lee, Jusun Moon, Hyungjong Park, Jung Hwa Seo, Kwon‐Duk Seo, Sung‐Il Sohn, Chang Jun Young, Rechdi Ahdab, Wan Asyraf Wan Zaidi, Zariah Abdul Aziz, Hamidon Basri, Law Wan Chung, Aznita Binti Ibrahim, Khairul Azmi Ibrahim, Irene Looi, Wee Yong Tan, Wan Yahya Nafisah, Stanislav Groppa, Pavel Leahu, Amal Al Hashmi, Yahia Imam, Naveed Akhtar, Maria Carissa Pineda-Franks, Christian Oliver, Д В Кандыба, Adel Alhazzani, Hosam Al-Jehani, Carol Huilian Tham, Marlie Jane Mamauag, Narayanaswamy Venketasubramanian, Chih‐Hao Chen, Sung‐Chun Tang, Anchalee Churojana, Eşref Akıl, Özlem Aykaç, Atilla Özcan Özdemi̇r, Semih Giray, Syed Hussain, Seby John, Huynh Le Vu, Anh Đức Trần, Huy Hoàng Nguyễn, Thong Nhu Pham, Thang Huy Nguyen, Trung Quoc Nguyen, Thomas Gattringer, Christian Enzinger, Monika Killer‐Oberpfalzer, Flavio Bellante, Sofie De Blauwe, Geert Vanhooren, Sylvie De Raedt, Anne Dusart, Robin Lemmens, Noémie Ligot, Matthieu Pierre Rutgers, Laetitia Yperzeele, Filip Alexiev, Teodora Sakelarova, Marina Roje Bedeković, Hrvoje Budinčević, Igor Cindrić, Zlatko Hucika, David Ozretić, Majda Seferovic Saric, František Pfeifer, Igor Karpowic, David Černík, Martin Šrámek, Miroslav Škoda, Helena Hlaváčová, Lukáš Klečka, Martin Koutny, Daniel Václavík, Ondřej Škoda, Jan Fiksa, Katerina Hanelova, Miroslava Nevšímalová, Robert Rezek, Petr Procházka, Gabriela Krejstova, Jiří Neumann, Marta Vachová, Henryk Brzezanski, David Hlinovský, Dusan Tenora, R Jura, Lubomír Jurák, Jan Novák, Aleš Novák, Zdenek Topinka, Petr Fibrich, Helena Sobolová, Ondřej Volný, Hanne Christensen, Nicolas Drenck, Helle K. Iversen, Claus Z. Simonsen, Thomas Truelsen, Troels Wienecke, Riina Vibo, Katrin Gross‐Paju, Toomas Toomsoo, Katrin Antsov, François Caparros, Charlotte Cordonnier, Maria Dan, Jean‐Marc Faucheux, Laura Mechtouff, Ömer EKER, É. Lesaine, Basile Ondzé, Roxane Peres, Fernando Pico, Michel Piotin, Raoul Pop, François Rouanet, Tatuli Gubeladze, Mirza Khinikadze, Nino Lobjanidze, Alexander Tsiskaridze, Simon Nagel, Peter A. Ringleb, Michael Rosenkranz, Holger Schmidt, Annahita Sedghi, Timo Siepmann, Kristina Szabo, Götz Thomalla, Lina Palaiodimou, Dimitrios Sagris, Odysseas Kargiotis, Péter Klivényi, László Szapáry, Gábor Tárkányi, Alessandro Adami, Fabio Bandini, Paolo Calabresi, Giovanni Frisullo, Leonardo Renieri, Davide Sangalli, Anne Pirson, Maarten Uyttenboogaart, Ido R. van den Wijngaard, Espen Saxhaug Kristoffersen, Waldemar Brola, Małgorzata Fudala, Ewa Horoch-Łyszczarek, Michał Karliński, Radosław Kaźmierski, Paweł Kram, Marcin Rogoziewicz, Rafał Kaczorowski, Piotr Luchowski, Halina Sienkiewicz‐Jarosz, Piotr Sobolewski, Waldemar Fryze, Anna Wiśniewska, M Wiszniewska, Patrícia Ferreira, Paulo Ferreira, Luísa Fonseca, João Pedro Marto, Teresa M. V. D. Pinho e Melo, Ana Paiva Nunes, Miguel Rodrigues,
To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods.We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.There were 91,373 stroke admissions in the 4 months ...
Lippincott Williams & Wilkins
Zahra Raisi‐Estabragh, Celeste McCracken, Jackie A. Cooper, Kenneth Fung, José Miguel Paiva, Mohammed Y Khanji, Elisa Rauseo, Luca Biasiolli, Betty Raman, Stefan K. Piechnik, Stefan Neubauer, Patricia B. Munroe, Nicholas C. Harvey, Steffen E. Petersen,
Coronavirus disease 2019 (COVID-19) disproportionately affects older people. Observational studies suggest indolent cardiovascular involvement after recovery from acute COVID-19. However, these findings may reflect pre-existing cardiac phenotypes.
Tópico(s): Cardiovascular Disease and Adiposity
2021 - Springer Science+Business Media | Aging Clinical and Experimental Research
Fabrizio Ricci, Nay Aung, Sabina Gallina, Filip Zemrak, Kenneth Fung, Giandomenico Bisaccia, José Miguel Paiva, Mohammed Y Khanji, Cesare Mantini, Stefano Palermi, Aaron M. Lee, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen,
Mitral valve (MV) and tricuspid valve (TV) apparatus geometry are essential to define mechanisms and etiologies of regurgitation and to inform surgical or transcatheter interventions. Given the increasing use of cardiovascular magnetic resonance (CMR) for the evaluation of valvular heart disease, we aimed to establish CMR-derived age- and sex-specific reference values for mitral annular (MA) and tricuspid annular (TA) dimensions and tethering indices derived from truly healthy Caucasian adults.
Tópico(s): Cardiac Imaging and Diagnostics
2021 - BioMed Central | Journal of Cardiovascular Magnetic Resonance
Edward Ferdian, Avan Suinesiaputra, Kenneth Fung, Nay Aung, Elena Lukaschuk, Ahmet Barutçu, Edd Maclean, José Miguel Paiva, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen, Alistair A. Young,
Purpose To demonstrate the feasibility and performance of a fully automated deep learning framework to estimate myocardial strain from short-axis cardiac MRI–tagged images. Materials and Methods In this retrospective cross-sectional study, 4508 cases from the U.K. Biobank were split randomly into 3244 training cases, 812 validation cases, and 452 test cases. Ground truth myocardial landmarks were defined and tracked by manual initialization and correction of deformable image registration using previously ...
Tópico(s): Advanced MRI Techniques and Applications
2020 - Radiological Society of North America | Radiology Cardiothoracic Imaging
Ana Cláudia Paiva‐Santos, Miguel Pereira‐Silva, Catarina Guerra, Diana Costa, Diana Peixoto, Irina Pereira, Inês Pita, António J. Ribeiro, Francisco Veiga,
Androgenetic alopecia (AGA) is a multifactorial and age-related condition characterized by substantial hair loss affecting both men and women. Conventional treatments include the use of topical minoxidil (MNX) formulations to stimulate hair growth and restore hair condition. However, those treatments are associated with limited performance and a lack of tolerability and compliance due to the emergence of adverse effects. Considering that the development of nanotechnology-based formulations as hair ...
Tópico(s): Skin Protection and Aging
2020 - Multidisciplinary Digital Publishing Institute | Cosmetics
Zahra Raisi‐Estabragh, Luca Biasiolli, Jackie Cooper, Nay Aung, Kenneth Fung, José Miguel Paiva, Mihir M. Sanghvi, Ross J Thomson, Elizabeth Curtis, Julien Paccou, Jennifer Rayner, Konrad Werys, Henrike Puchta, Katharine Thomas, Aaron M. Lee, Stefan K. Piechnik, Stefan Neubauer, Patricia B. Munroe, Cyrus Cooper, Steffen E. Petersen, Nicholas C. Harvey,
ABSTRACT Osteoporosis and ischemic heart disease (IHD) represent important public health problems. Existing research suggests an association between the two conditions beyond that attributable to shared risk factors, with a potentially causal relationship. In this study, we tested the association of bone speed of sound (SOS) from quantitative heel ultrasound with (i) measures of arterial compliance from cardiovascular magnetic resonance (aortic distensibility [AD]); (ii) finger photoplethysmography (arterial ...
Tópico(s): Biomarkers in Disease Mechanisms
2020 - Oxford University Press | Journal of Bone and Mineral Research
Patrícia Patrício, José Artur Paiva, Luís Miguel Borrego,
Sepsis leads to a systemic immune response, and despite the progress of modern medicine, it is still responsible for a high mortality rate. The immune response to sepsis is dependent on the innate and adaptive immune systems. The first line is the innate system, which requires complex and multiple pathways in order to eliminate the invading threats. The adaptive responses start after the innate response. The cell-mediated arm of CD4+ and CD8+ T and B cells is the main responsible for this response. ...
Tópico(s): Inflammasome and immune disorders
2019 - Akadémiai Kiadó | European Journal of Microbiology and Immunology
Sebastian E. Beyer, Mihir M. Sanghvi, Nay Aung, Alice Hosking, Jackie Cooper, José Miguel Paiva, Aaron M. Lee, Kenneth Fung, Elena Lukaschuk, Valentina Carapella, Murray A. Mittleman, Søren Brage, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen,
Background Handgrip strength, a measure of muscular fitness, is associated with cardiovascular (CV) events and CV mortality but its association with cardiac structure and function is unknown. The goal of this study was to determine if handgrip strength is associated with changes in cardiac structure and function in UK adults. Methods and results Left ventricular (LV) ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), mass (M), and mass-to-volume ratio (MVR) ...
Tópico(s): Cardiovascular Disease and Adiposity
2018 - Public Library of Science | PLoS ONE
Mihir M. Sanghvi, Nay Aung, Jackie Cooper, José Miguel Paiva, Aaron M. Lee, Filip Zemrak, Kenneth Fung, Ross J Thomson, Elena Lukaschuk, Valentina Carapella, Young Jin Kim, Nicholas C. Harvey, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen,
Background The effect of menopausal hormone therapy (MHT)–previously known as hormone replacement therapy–on cardiovascular health remains unclear and controversial. This cross-sectional study examined the impact of MHT on left ventricular (LV) and left atrial (LA) structure and function, alterations in which are markers of subclinical cardiovascular disease, in a population-based cohort. Methods Post-menopausal women who had never used MHT and those who had used MHT ≥3 years participating in the UK ...
Tópico(s): Cardiovascular Disease and Adiposity
2018 - Public Library of Science | PLoS ONE
Nay Aung, Mihir M. Sanghvi, Filip Zemrak, Aaron M. Lee, Jackie Cooper, José Miguel Paiva, Ross J Thomson, Kenneth Fung, Mohammed Y Khanji, Elena Lukaschuk, Valentina Carapella, Young Jin Kim, Patricia B. Munroe, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen,
Background: Exposure to ambient air pollution is strongly associated with increased cardiovascular morbidity and mortality. Little is known about the influence of air pollutants on cardiac structure and function. We aim to investigate the relationship between chronic past exposure to traffic-related pollutants and the cardiac chamber volume, ejection fraction, and left ventricular remodeling patterns after accounting for potential confounders. Methods: Exposure to ambient air pollutants including ...
Tópico(s): Air Quality Monitoring and Forecasting
2018 - Lippincott Williams & Wilkins | Circulation