João Vieira, João Marcelino, Fátima Ferreira, Sofia Farinha, Rita Silva, Miguel Proença, Elza Tomáz,
... Fátima Ferreira. Formal analysis: João Vieira, Rita Silva, Miguel Proença. Investigation: João Vieira, João Marcelino, Fátima Ferreira, Sofia Farinha, Rita Silva, Miguel Proença, Elza Tomaz. Methodology: Elza Tomaz, João Marcelino, Sofia ...
Tópico(s): Food Allergy and Anaphylaxis Research
2021 - Lippincott Williams & Wilkins | Asia Pacific Allergy
Mário Arala‐Chaves, Rui Proença, Miguel de Sousa,
A young woman with unclassified complex immune deficiency disease characterized by relapsing skin ulcerations, greatly depressed cellular immunity, absent serum IgA, and inability to develop circulating antibodies to typhoid vaccine, was treated twice with the dialyzable transfer factor from normal persons. Following such therapy she showed clinical improvement and strong delayed skin sensitivity to Candida, streptokinase-streptodornase, and moderate, rather short-lived hypersensitivity to PPD. ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
1974 - Elsevier BV | Cellular Immunology
L. Calado, Jorge Proença, Miguel Espinha, Carlo Andrea Castiglioni,
In recent years there has been increasing international interest about designing structures that cost less to repair after they have been subjected to strong earthquakes. Considering this interest, an innovative repairable fuse device has been developed for dissipative beam-to-column connections in moment-resisting composite steel and concrete frames. The seismic performance of the device was assessed through an extensive experimental program comprising ten cyclic and two monotonic tests. These ...
Tópico(s): Structural Load-Bearing Analysis
2013 - Technopress | Steel and Composite Structures
Sara Proença, Miguel St. Aubyn,
Feed-in tariffs have been the main policy instrument applied in Portugal for the promotion of electricity produced from renewable energy sources under the EU Directives on energy and climate regulation. In this paper, we provide an empirical impact assessment of the economic and environmental effects of Portugal's FITs policy to promote RES-E generation. Impact assessment of policy instruments plays a crucial role on decision-making process. For numerical simulations, we make use of a hybrid top- ...
Tópico(s): Energy, Environment, and Transportation Policies
2013 - Elsevier BV | Energy Economics
L. Calado, Jorge Proença, Miguel Espinha, Carlo Andrea Castiglioni,
One of the most recent trends in earthquake-resistant design of structures – damage control when these are subjected to severe earthquakes – led to the development of an innovative repairable fuse device for dissipative beam-to-column connections in moment resistant steel frames with composite beams. This fuse consists of a set of bolted steel plates, at the web and bottom flange, connecting the “I” beam profile stub to the beam element. The seismic performance of the proposed device was assessed through ...
Tópico(s): Structural Load-Bearing Analysis
2013 - Elsevier BV | Journal of Constructional Steel Research
Mariana P. Proença, Miguel Mota Prego Rosmaninho, Pedro M. Resende, C. T. Sousa, J. Ventura, João P. Araújo, Lisete Fernandes, Pedro B. Tavares, André M. Pereira,
Bi2Te3 is the most commonly used thermoelectric material in modern solid-state refrigerators and power generators based on this basic principle. Due to predictions of significant improvements in their efficiency by using nanostructured materials, a thorough study on thin films and nanowires deposited by the electrodeposition method are here presented. The study of the deposition applied potential effect on the morphology, stoichiometry and crystallinity of both thin films and nanowires has been ...
Tópico(s): nanoparticles nucleation surface interactions
2017 - Elsevier BV | Materials & Design
Júlio Belo Fernandes, Catarina Ramos, Josefa Domingos, Cidália Castro, Aida Simões, Catarina Bernardes, Jorge Fonseca, Luís Proença, Miguel Grunho, Paula Moleirinho-Alves, Sérgio Simões, Diogo Sousa-Catita, Diana Alves Vareta, Catarina Godinho,
Ageism refers to stereotyping (how we think), prejudice (how we feel), and discrimination (how we act) against people based on their age. It is a serious public health issue that can negatively impact older people’s health and quality of life. The present protocol has several goals: (1) adapt the Ambivalent Ageism Scale for the general Portuguese population and healthcare professionals; (2) assess the factorial invariance of the questionnaire between general population vs. healthcare professionals; (3) ...
Tópico(s): Health disparities and outcomes
2022 - Multidisciplinary Digital Publishing Institute | Journal of Personalized Medicine
Paula Proença, João Miguel Franco, Carla Mustra, Mariana Marcos, Ana Rita Pereira, Francisco Gonçalves, Duarte Nuno Vieira,
Valproic acid (VPA) has been used as an anticonvulsant for the treatment of epilepsy. The authors present a fatal case involving a 45-year-old female, found dead lying in bed with empty tablets of Diplexil(®) next to her. She was a chronic alcoholic and epileptic who had been under psychiatric treatment, having repeatedly demonstrated intent to commit suicide. A rapid method was developed and validated to determine VPA in blood by ultra-performance liquid chromatography (UPLC) coupled with tandem ...
Tópico(s): Neurological Complications and Syndromes
2011 - Elsevier BV | Journal of Forensic and Legal Medicine
Paula Proença, João Miguel Franco, Carla Mustra, Carla Monteiro, Joana Costa, Francisco Gonçalves, Duarte Nuno Vieira,
Trends in forensic toxicology show the introduction of rapid analytical methods for the simultaneous quantitative analysis of drugs. The authors present a fatal case involving a 32-year-old male, found dead in bed by his mother, with several blue, white and orange pills next to the body. Empty tablets were found in the trash bin and a suicide note was on the desk. He was diagnosed with bipolar disorder and had been under psychiatric treatment, having repeatedly demonstrated intent to commit suicide. ...
Tópico(s): Analytical Chemistry and Chromatography
2012 - Elsevier BV | Forensic Science International
Carlos Fernandes, Diogo Miguel Proença Rocha, Ramiro C. Martins, Luís Magalhães, J. Seabra,
A FEM thermal model was implemented to predict the bulk and flash temperature of gears in general and polymer gears in particular. Using the capabilities of a gear power loss model previously validated, a solution for the temperature rise and distribution along the tooth is suggested. The accuracy of the power loss model is decisive for the prediction of gear temperature field by FEM model. The FEM model was validated with experimental results from the literature. The model allows to predict the ...
Tópico(s): Advanced machining processes and optimization
2017 - Elsevier BV | Tribology International
Carlos Fernandes, Diogo Miguel Proença Rocha, Ramiro C. Martins, Luís Magalhães, J. Seabra,
A drawback of polymer materials is their low thermal conductivity which affects the operating temperature of polymer gears. The mechanical properties of a polymer gear are critically dependent on the maximum operating temperature. In order to improve thermal behavior of polymer gears, a hybrid polymer gear concept is suggested which consists of a polymer gear tooth with a metallic insert to promote heat evacuation from the meshing surface. The material selection based on finite element method (FEM) ...
Tópico(s): Gear and Bearing Dynamics Analysis
2018 - ASM International | Journal of Tribology
Ana T. Rufino, Marisa Freitas, Carina Proença, José Miguel P. Ferreira de Oliveira, Eduarda Fernandes, Daniela Ribeiro,
Abstract Rheumatoid arthritis (RA) is a progressive, chronic, autoimmune, inflammatory, and systemic condition that primarily affects the synovial joints and adjacent tissues, including bone, muscle, and tendons. The World Health Organization recognizes RA as one of the most prevalent chronic inflammatory diseases. In the last decade, there was an expansion on the available RA therapeutic options which aimed to improve patient's quality of life. Despite the extensive research and the emergence of ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2023 - Wiley | Medicinal Research Reviews
João Marcelino, Sofia Farinha, Rita Silva, Irina Didenko, Miguel Proença, Elza Tomáz,
Clinical Implications•Skin testing (prick test and intradermal test) can be performed with the Pfizer-BioNtech severe acute respiratory syndrome coronavirus 2 vaccine, up to the undiluted form, without the risk of eliciting an immediate irritant reaction. This finding can help the evaluation of patients with an immediate reaction to the first dose of the vaccine or with a suspected immediate reaction to a component of the vaccine and who require vaccination due to the coronavirus pandemic. •Skin testing ( ...
Tópico(s): Biosimilars and Bioanalytical Methods
2021 - Elsevier BV | The Journal of Allergy and Clinical Immunology In Practice
Daniela Proença, Clara Leandro, Miguel García, Madalena Pimentel, Carlos São‐José,
Tópico(s): Microbial infections and disease research
2015 - Springer Science+Business Media | Applied Microbiology and Biotechnology
Carlos Cavaleiro, Lı́gia Salgueiro, Maria Graça Miguel, A. Proença da Cunha,
The essential oils from four samples of Teucrium lusitanicum and one sample of Teucrium algarbiensis, grown in Algarve (southern Portugal) were analyzed by gas chromatography (GC) and gas chromatography–mass spectroscopy (GC–MS). Seventy-one volatile compounds were identified. Major compounds of T. algarbiensis oil were α-pinene (8.3%), sabinene (7.2%), β-pinene (10.2%), limonene (11.8%) and germacrene D (7.6%). Concerning T. lusitanicum, some quantitative differences were found with regards to the major ...
Tópico(s): Natural product bioactivities and synthesis
2004 - Elsevier BV | Journal of Chromatography A
Produção Nacional
Revisado por pares
Cyntia Erthal Leinig, Thyago Proença de Moraes, Silvia Carreira Ribeiro, Miguel C. Riella, Márcia Olandoski, Cristina Martins, Roberto Pecoits–Filho,
Tópico(s): Iron Metabolism and Disorders
2010 - Elsevier BV | Journal of Renal Nutrition
Daniela Proença, Christophe Velours, Clara Leandro, Miguel García, Madalena Pimentel, Carlos São‐José,
Bacteriophage endolysins are bacterial cell wall degrading enzymes whose potential to fight bacterial infections has been intensively studied. Endolysins from Gram-positive systems are typically described as monomeric and as having a modular structure consisting of one or two N-terminal catalytic domains (CDs) linked to a C-terminal region responsible for cell wall binding (CWB). We show here that expression of the endolysin gene lys170 of the enterococcal phage F170/08 results in two products, the ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2014 - Wiley | Molecular Microbiology
Rita Pinto Proença, Bruno F. Fernandes, Miguel N. Burnier, Rui Proença,
The authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. ...
Tópico(s): Breast Lesions and Carcinomas
2018 - BMJ | BMJ Case Reports
Carla Monteiro, João Miguel Franco, Paula Proença, Antonio Castañera Ajenjo, Alda Claro, Duarte Nuno Vieira, Francisco Gonçalves,
Tópico(s): Metabolomics and Mass Spectrometry Studies
2014 - Elsevier BV | Forensic Science International
Marta Guedes, Luís Miguel Borrego, Rui Proença,
Th17 cells, a CD4+ T-cell subset, produce interleukin (IL)-17, a pro-inflammatory cytokine that has been shown to be involved in several forms of infectious and noninfectious uveitis. Here, we explore the roles of this IL in uveitic disorders as well as in experimental autoimmune uveitis, the possible pathogenic implications of several cytokines associated with IL-17 and analyze the current outcomes and goals for drugs aiming for the IL-17 pathway.
Tópico(s): Systemic Lupus Erythematosus Research
2016 - Medknow | Indian Journal of Ophthalmology
Paula Proença, Carla Mustra, Mariana Marcos, João Miguel Franco, Francisco Gonçalves, Duarte Nuno Vieira,
The use of synthetic phosphodiesterase type 5 (PDE-5) inhibitors for the treatment of erectile dysfunction: sildenafil citrate (Viagra(®)), tadalafil (Cialis(®)) and vardenafil hydrochloride (Levitra(®)) has increased dramatically over the past 2 years. These substances are prescription drugs and must be used under medical supervision. However, they can easily be obtained over the internet from illegal sites, being a potential for a threat to public health. The development of an electrospray ionisation ( ...
Tópico(s): Pharmaceutical Quality and Counterfeiting
2013 - Elsevier BV | Journal of Forensic and Legal Medicine
Marta Guedes, Maria Arroz, Catarina Martins, Miguel Ângelo‐Dias, Rui Proença, Luís Miguel Borrego,
Tópico(s): Vasculitis and related conditions
2020 - Springer Science+Business Media | Graefe s Archive for Clinical and Experimental Ophthalmology
Vânia Proença, Laura J. Martin, Henrique M. Pereira, Miguel Fernández, Louise McRae, Jayne Belnap, Monika Böhm, Neil Brummitt, Jaime García‐Moreno, Richard D. Gregory, João P. Honrado, Norbert Jürgens, Michael Opige, Dirk S. Schmeller, Patrícia Tiago, Chris van Swaay,
Essential Biodiversity Variables (EBVs) consolidate information from varied biodiversity observation sources. Here we demonstrate the links between data sources, EBVs and indicators and discuss how different sources of biodiversity observations can be harnessed to inform EBVs. We classify sources of primary observations into four types: extensive and intensive monitoring schemes, ecological field studies and satellite remote sensing. We characterize their geographic, taxonomic and temporal coverage. ...
Tópico(s): Wildlife Ecology and Conservation
2016 - Elsevier BV | Biological Conservation
Carina Proença, Ana T. Rufino, José Miguel P. Ferreira de Oliveira, Marisa Freitas, Pedro Alexandrino Fernandes, Artur M. S. Silva, Eduarda Fernandes,
Type 2 diabetes (T2D) is the most common form of diabetes, and the number of people with this metabolic disease is steadily increasing worldwide. Among the available antidiabetic agents, α-glucosidase inhibitors are the most effective at reducing postprandial hyperglycaemia (PPHG), one of the main characteristics of T2D. However, most of the studies that have been performed have used the more readily available rat intestinal preparations or yeast α-glucosidase as the enzyme source, which despite being ...
Tópico(s): Diet, Metabolism, and Disease
2022 - Royal Society of Chemistry | Food & Function
Produção Nacional
Revisado por pares
Rogério Antônio Laurato Sertié, Sandra Andreotti, André Ricardo Gomes de Proença, Amanda Baron Campaña, Thaís Martins de Lima, Miguél L. Batista, Marília Seelaender, Rui Curi, Ariclécio Cunha de Oliveira, Fábio Bessa Lima,
All of the adaptations acquired through physical training are reversible with inactivity. Although significant reductions in maximal oxygen uptake (V̇o 2max ) can be observed within 2 to 4 wk of detraining, the consequences of detraining on the physiology of adipose tissue are poorly known. Our aim was therefore to investigate the effects of discontinuing training (physical detraining) on the metabolism and adipocyte cellularity of rat periepididymal (PE) adipose tissue. Male Wistar rats, aged 6 wk, ...
Tópico(s): Cardiovascular Disease and Adiposity
2013 - American Physiological Society | Journal of Applied Physiology
Laetitia M. Navarro, Alexandra Marques, Vânia Proença, Silvia Ceaușu, Bárbara Gonçalves, César Capinha, Miguel Fernández, Jonas Geldmann, Henrique M. Pereira,
Restoration ecology is gaining momentum on the international conservation scene. In particular, restoring degraded ecosystems is central to Aichi Biodiversity Targets 14 and 15 set by the Convention on Biological Diversity. Depending on the definition of degradation, from 2 to 47% of the global land surface could require restoration. Here, we review the range of goals and approaches to restoration, from active interventions to more passive approaches such as rewilding. We identify biodiversity offsets, ...
Tópico(s): Land Use and Ecosystem Services
2017 - Elsevier BV | Current Opinion in Environmental Sustainability
Produção Nacional
Revisado por pares
Tobias August Siemens, Miguel C. Riella, Thyago Proença de Moraes, Cristian V. Riella,
There are striking differences in chronic kidney disease between Caucasians and African descendants. It was widely accepted that this occurred due to socioeconomic factors, but recent studies show that apolipoprotein L-1 (APOL1) gene variants are strongly associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, hypertensive nephrosclerosis, and lupus nephritis in the African American population. These variants made their way to South America trough intercontinental slave traffic ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2018 - Sociedade Brasileira de Nefrologia | Brazilian Journal of Nephrology
Marta Ilharco, Carla Maravilha Pereira, Laura Magalhães Moreira, Ana Luísa Proença, Maria do Carmo Fevereiro, Fátima Lampreia, Miguel Lopes Oliveira, José Rola,
Mucormycosis is a severe opportunistic fungal infection caused by Mucorales. The majority of the affected patients have a history of immunosuppression, with a reported incidence of 4-19% in the immunocompetent. Early recognition and diagnosis, combined with surgical debridement and appropriate antifungal therapy are essential to achieve a cure. In this article we report the case of a 61-year-old immunocompetent male who complained with pain in his right eye. After being first diagnosed with conjunctivitis ...
Tópico(s): Ocular Infections and Treatments
2019 - Elsevier BV | IDCases
Produção Nacional
Revisado por pares
Cristian V. Riella, Tobias August Siemens, Minxian Wang, Rodrigo Peixoto Campos, Thyago Proença de Moraes, Leonardo V. Riella, David J. Friedman, Miguel C. Riella, Martin R. Pollak,
Coding variants in apolipoprotein L-1 (APOL1) are associated with an increased risk of end-stage kidney disease (ESRD) in African American individuals under a recessive model of inheritance. The effect of the APOL1 risk alleles on kidney disease has been observed in studies in African American and African populations. Despite the 130 million individuals of recent African ancestry in South America, the impact of APOL1 has not been explored.In this case-control study, we tested APOL1 genotype in 106 ...
Tópico(s): Chronic Kidney Disease and Diabetes
2019 - Elsevier BV | Kidney International Reports
Paula Proença, Carla Monteiro, Carla Mustra, Alda Claro, João Miguel Franco, Francisco Gonçalves,
Abstract Antipsychotic drugs (AP) are widely prescribed for the treatment of schizophrenia and psychosis. The pharmacological treatment of schizophrenia is often performed with the simultaneous use of two or more antipsychotic agents to achieve the desired control of psychotic symptoms Available AP include both conventional (typical) and new (atypical) antipsychotic medications. Atypical AP, such as quetiapine, now account for the vast majority of AP prescriptions. In forensic toxicology, AP are of ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2020 - Oxford University Press | Journal of Analytical Toxicology