Kogularamanan Suntharalingam, Deepali Gupta, Pablo J. Sanz Miguel, Bernhard Lippert, Ramón Vilar,
... 3797Search for more papers by this authorPablo J. Sanz Miguel Dr., Pablo J. Sanz Miguel Dr. Fakultät Chemie, Technische Universität Dortmund, 44221 Dortmund ( ... 3797Search for more papers by this authorPablo J. Sanz Miguel Dr., Pablo J. Sanz Miguel Dr. Fakultät Chemie, Technische Universität Dortmund, 44221 Dortmund ( ...
Tópico(s): Metal complexes synthesis and properties
2010 - Wiley | Chemistry - A European Journal
Guillermo Sanz, Miguel Á. Sanz, Teresa Vallespı́, M.C. Cañizo,
... ySearch for more papers by this authorMiguel A. Sanz, Miguel A. Sanz Servicios de Hematología, Hospital La Fe ( ... ySearch for more papers by this authorMiguel A. Sanz, Miguel A. Sanz Servicios de Hematología, Hospital La Fe (Valencia), *Vall ... anemia. Blood, 71, 305– 312. Sanz, G.F., Sanz, M.A., Vallespí, T., Cañizo, M.C., Torrabadella, M., García, S., Irriguible, D. & San Miguel, J.F. (1989) Two regression models and a ...
Tópico(s): Gestational Trophoblastic Disease Studies
1990 - Wiley | British Journal of Haematology
M. Guinot, Guillermo Sanz, Amparo Sempere, María J. Arilla, Isidro Jarque, F Gomis, Miguel Á. Sanz,
... SpainSearch for more papers by this authorMiguel A. Sanz, Miguel A. Sanz Department of Haematology, Hospital Universitario La ... SpainSearch for more papers by this authorMiguel A. Sanz, Miguel A. Sanz Department of Haematology, Hospital Universitario La Fe, Valencia, ...
Tópico(s): Chronic Myeloid Leukemia Treatments
1991 - Wiley | British Journal of Haematology
Anupam Khutia, Pablo J. Sanz Miguel, Bernhard Lippert,
... see the accompanying paper: A. Khutia, P. J. Sanz Miguel, B. Lippert, Chem. Eur. J. 2011 , 17 , DOI: ...
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2011 - Wiley | Chemistry - A European Journal
Anupam Khutia, Pablo J. Sanz Miguel, Bernhard Lippert,
... accompanying paper (Part I: A. Khutia, P. J. Sanz Miguel, B. Lippert, Chem. Eur. J. 2010 , 17 , DOI: ...
Tópico(s): Supramolecular Chemistry and Complexes
2011 - Wiley | Chemistry - A European Journal
Guillermo Sanz, F Gomis, Miguel Á. Sanz,
... SpainSearch for more papers by this authorMiguel A. Sanz, Miguel A. Sanz Servicio de Hematología, Hospital La Fe, ... SpainSearch for more papers by this authorMiguel A. Sanz, Miguel A. Sanz Servicio de Hematología, Hospital La Fe, Valencia, SpainSearch ...
Tópico(s): Chronic Lymphocytic Leukemia Research
1986 - Wiley | British Journal of Haematology
M. Carmen Carreño, J.L.G. Ruano, Gema Sanz, Miguel A. Toledo, Antonio Urbano,
... NaphthalenesM. Carmen Carreno, Jose L. Garcia Ruano, Gema Sanz, Miguel A. Toledo, and Antonio UrbanoCite this: J. Org. ...
Tópico(s): Synthesis of Tetrazole Derivatives
1995 - American Chemical Society | The Journal of Organic Chemistry
... Mufti, Radana Neuwirtova, Kazuma Ohyashiki, David Oscier, Guillermo Sanz, Miguel Sanz, and Cheryl Willman. Their affiliations are as follows: ...
Tópico(s): Lymphoma Diagnosis and Treatment
2000 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Mariano Linares, Emilio Pastor, Isidro Jarque, Guillermo Sanz, Miguel Á. Sanz,
... Valencia, SpainSearch for more papers by this authorMiguel Sanz MD, Miguel Sanz MD Department of Clinical Hematology, Hematology Service, ... Valencia, SpainSearch for more papers by this authorMiguel Sanz MD, Miguel Sanz MD Department of Clinical Hematology, Hematology Service, Hospital ...
Tópico(s): Hemoglobinopathies and Related Disorders
1988 - Wiley | American Journal of Hematology
Juan Berenguer, Juan L. Rodrı́guez-Tudela, Carlos Richard, María Elena Álvarez, Miguel Á. Sanz, L Gaztelurrutia, Josefina Ayats, Joaquı́n V. Martı́nez-Suárez,
... Richard, Carlos M.D.; Alvarez, Maria M.D.; Sanz, Miguel A. M.D.; Gaztelurrutia, Lourdes M.D.; Ayats, ...
Tópico(s): Infectious Diseases and Mycology
1997 - Wolters Kluwer | Medicine
Javier de la Rubia, Gema Plumé, F Arriaga, Nelly Carpio, Miguel Á. Sanz, Marı́a L. Marty,
... SpainSearch for more papers by this authorMiguel A. Sanz MD, Miguel A. Sanz MD e-mail: [email protected] Servicio ... SpainSearch for more papers by this authorMiguel A. Sanz MD, Miguel A. Sanz MD e-mail: [email protected] Servicio de Hematología ...
Tópico(s): Hemoglobinopathies and Related Disorders
2002 - Wiley | Transfusion
Alba Vellé, Andrea Cebollada, Ramón Macı́as, Manuel Iglesias, María Gil‐Moles, Pablo J. Sanz Miguel,
Investigations dealing with N-heterocyclic carbenes and their derivatives are usually centered on the influence that they exert by acting as catalysts, ionic liquids, or metallodrugs and consequently on their capabilities to tune the properties and reactivity of these systems. In this context, we aimed to focus on the internal molecular changes undergone by imidazole derivatives, from electronic and geometrical points of view. This work represents an empirical evidence of the molecular modifications ...
Tópico(s): Carbon dioxide utilization in catalysis
2017 - American Chemical Society | ACS Omega
Bernhard Lippert, Pablo J. Sanz Miguel,
As is well established, numerous similarities exist as far as reactivity patterns and structural features of the d8 metal ions M = Pd2+ and Pt2+ are concerned. Here reactions of metal complexes of type cis-[M(a)2X2] (a = NH3 or (a)2 = diamine or diimine; X = monodentate or X2 = bidentate leaving groups) with nucleobases, the constituents of nucleic acids, are discussed and differences regarding intrinsic stability of the starting compounds, kinetics of formation of products, thermodynamics of products, as well ...
Tópico(s): Magnetism in coordination complexes
2017 - Elsevier BV | Inorganica Chimica Acta
Alba Vellé, Ronan Maguire, Kevin Kavanagh, Pablo J. Sanz Miguel, Diego Montagner,
A series of gold(I) pioneer complexes bearing N-heterocyclic carbenes and steroid derivatives (ethynylestradiol and ethisterone) with the generic formula [Au(R2 -imidazol-2-ylidene)(steroid)] (where R=CH3 or CH2 CH2 OCH3 ) were synthesized, and the X-ray structure of a rare of gold(I)-estradiol derivative is discussed. Toxicity studies reveal notable antibacterial activity of the gold-based compounds, which is significantly increased in vivo by the presence of the estradiol unit. Toxicity profiling was ...
Tópico(s): Synthesis and Biological Evaluation
2017 - Wiley | ChemMedChem
Amaia Iturmendi, Néstor Garcı́a, E. A. Jaseer, Julen Munárriz, Pablo J. Sanz Miguel, Víctor Polo, Manuel Iglesias, Luis A. Oro,
The Ir(i) complexes [Ir(cod)(κP,C,P'-NHO(PPh2))]PF6 and [IrCl(cod)(κC-NHO(OMe))] (cod = 1,5-cyclooctadiene, NHO(PPh2) = 1,3-bis(2-(diphenylphosphanyl)ethyl)-2-methyleneimidazoline) and NHO(OMe) = 1,3-bis(2-(methoxyethyl)-2-methyleneimidazoline), both featuring an N-heterocyclic olefin ligand (NHO), have been tested in the transfer hydrogenation reaction; this representing the first example of the use of NHOs as ancillary ligands in catalysis. The pre-catalyst [Ir(cod)(κP,C,P'-NHO(PPh2))]PF6 has shown excellent ...
Tópico(s): Organometallic Complex Synthesis and Catalysis
2016 - Royal Society of Chemistry | Dalton Transactions
Francisco Aznárez, Manuel Iglesias, Alexander Hepp, Benjamin Veit, Pablo J. Sanz Miguel, Luis A. Oro, Guo‐Xin Jin, F. Ekkehardt Hahn,
The Ir III complexes 4 and 5 bearing bis‐NHC ligands (NHC = N‐heterocyclic carbene) composed of one classical NR,NR NHC and one N,NR NHC donor were prepared by the reaction of the azolium/azole compounds 2 I and 3 Br, respectively, with [{Cp*IrCl(µ‐Cl)} 2 ] (Cp*=η 5 ‐C 5 Me 5 ) in the presence of NaOAc as base. Most likely, the salts 2 I and 3 Br were first selectively deprotonated at the C2 position of the disubstituted (NR,NR) diazaheterocycle to generate an NHC donor, which then coordinated to the Ir III ...
Tópico(s): Catalytic Cross-Coupling Reactions
2016 - Wiley | European Journal of Inorganic Chemistry
Bernhard Lippert, Pablo J. Sanz Miguel,
ConspectusThe significance of metal ions for the function and properties of DNA and RNA, long seen primarily under biological aspects and medicinal uses, has recently gained a renewed momentum. This is a consequence of the advent of novel applications in the fields of materials science, biotechnology, and analytical sensor chemistry that relate to the designed incorporation of transition metal ions into nucleic acid base pairs. Ag+ and Hg2+ ions, binding to pyrimidine (pym) nucleobases, represent ...
Tópico(s): Molecular Sensors and Ion Detection
2016 - American Chemical Society | Accounts of Chemical Research
Bernhard Lippert, Pablo J. Sanz Miguel,
This article reviews discrete complexes of platinum in its common oxidation states +II, +III, and +IV with aqua, hydroxido, oxido, and peroxido ligands, which at some point had been considered unstable and difficult to isolate because of an incompatibility between the "soft" nature of the metal and the "hard" nature of the O-ligands. The sheer number of structurally fully characterized examples contradicts this view, and numerous studies confirm their existence in solution and reveal at the same time ...
Tópico(s): Lanthanide and Transition Metal Complexes
2016 - Elsevier BV | Coordination Chemistry Reviews
Francisco Aznárez, Pablo J. Sanz Miguel, Tristan Tsai Yuan Tan, F. Ekkehardt Hahn,
Two molecules of 4,5-dichloroimidazole react with dibromomethane to give the diimidazole 1. Reaction of 1 with iodomethane or 2-fluorobenzyl bromide yields the monoalkylated imidazolium/imidazole salts [2]I and [3]Br, respectively. Salt [2]I reacts with Ag2O followed by transmetalation to [Rh(Cp*)(Cl)2]2 to give the RhIII-NHC complex [4], bearing an NHC ligand with a pendant imidazole group. The pendant imidazole can be deprotonated using NaOAc to yield complex [5], bearing a doubly C-metalated C∧C chelate ...
Tópico(s): Synthetic Organic Chemistry Methods
2016 - American Chemical Society | Organometallics
Manuel Iglesias, Amaia Iturmendi, Pablo J. Sanz Miguel, Víctor Polo, Jesús J. Pérez‐Torrente, Luis A. Oro,
A new PCP-type ligand based on an N-heterocyclic olefin (NHO) scaffold has been prepared. The flexibility of this ligand, which is able to adopt facial coordination modes in Ir(I) or meridional in Ir(III) complexes, can be attributed to the dual nature (ylide-olefin) of the NHO scaffold. This results in a rare case of olefin "slippage" that is supported by X-ray crystallography and DFT calculations.
Tópico(s): Catalytic Cross-Coupling Reactions
2015 - Royal Society of Chemistry | Chemical Communications
Néstor Garcı́a, E. A. Jaseer, Julen Munárriz, Pablo J. Sanz Miguel, Víctor Polo, Manuel Iglesias, Luis A. Oro,
Abstract A variety of [M(L) 2 (L′) 2 {κ C , C ′‐bis(NHC)}]BF 4 complexes (M = Rh or Ir; L = CH 3 CN or wingtip group; L′ = I – or CF 3 COO – ; NHC=N‐heterocyclic carbene) have been tested as pre‐catalysts for the transfer hydrogenation of ketones and imines. The conversions and TOF's obtained are closely related to the nature of the ligand system and metal centre, more strongly coordinating wingtip groups yielding more active and recyclable catalysts. Theoretical calculations at the DFT level support a classic stepwise ...
Tópico(s): Catalytic Cross-Coupling Reactions
2015 - Wiley | European Journal of Inorganic Chemistry
Manuel Iglesias, Mélanie Aliaga‐Lavrijsen, Pablo J. Sanz Miguel, Francisco J. Fernández‐Álvarez, Jesús J. Pérez‐Torrente, Luis A. Oro,
Abstract We describe a bis‐N‐heterocyclic carbene rhodium(III) complex, featuring two trifluoroacetato ligands, that affords a variety of α‐vinylsilanes in good yields by hydrosilylation of terminal alkynes. Selectivities around 7:1 α/β‐( E ) were reached, while the β‐( Z ) product was only marginally obtained. This example sharply contrasts with the β‐( Z )‐selectivity observed for its parent diiodido complex magnified image
Tópico(s): Catalytic Cross-Coupling Reactions
2015 - Wiley | Advanced Synthesis & Catalysis
Andrea Cebollada, Alba Vellé, Manuel Iglesias, Lauren B. Fullmer, Sara Goberna‐Ferrón, May Nyman, Pablo J. Sanz Miguel,
The study of the aggregation of small molecules in solution induced by metallophilic interactions has been traditionally performed by spectroscopic methods through identification of chemical changes in the system. Herein we demonstrate the use of SAXS (small-angle X-ray scattering) to identify structures in solution, taking advantage of the excellent scattering intensity of heavy metals which have undergone association by metallophilic interactions. An analysis of the close relationship between solid- ...
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2015 - Wiley | Angewandte Chemie International Edition
Laura Rubio‐Pérez, Manuel Iglesias, Julen Munárriz, Víctor Polo, Pablo J. Sanz Miguel, Jesús J. Pérez‐Torrente, Luis A. Oro,
A new Ir(ii) complex [{Ir(μ-κCNHC,η(6)Dipp-IDipp)(H)}2][BF4]2 has been prepared and fully characterised. This complex acts as a catalyst for the hydroalkynylation of imines according to an unprecedented diiridium-mediated mechanism.
Tópico(s): Synthetic Organic Chemistry Methods
2015 - Royal Society of Chemistry | Chemical Communications
Mélanie Aliaga‐Lavrijsen, Manuel Iglesias, Andrea Cebollada, Karin Garcés, Néstor Garcı́a, Pablo J. Sanz Miguel, Francisco J. Fernández‐Álvarez, Jesús J. Pérez‐Torrente, Luis A. Oro,
New [Ir(CH3CN)2(I)2{κC,C′-bis(NHC)}]BF4 complexes featuring bis-NHC ligands with a methylene bridge and different N substitution (−CH2CH2CH2CH3 and −CH2CH2OPh) were synthesized. NMR studies and X-ray diffraction structures evidenced that the wingtip group −CH2CH2OPh presents a hemilabile behavior in solution, with the oxygen atom coordinating and dissociating at room temperature, which contrasts with the strong coordination of the ether functions in the complex [Ir(I)2{κC,C′,O,O′-bis(NHCOMe)}]BF4 (bis( ...
Tópico(s): Catalytic Cross-Coupling Reactions
2014 - American Chemical Society | Organometallics
Célia Fonseca Guerra, Pablo J. Sanz Miguel, Andrea Cebollada, F. Matthias Bickelhaupt, Bernhard Lippert,
Abstract The exocyclic amino groups of cytosine and adenine nucleobases are normally almost flat, with the N atoms essentially sp 2 hybridized and the lone pair largely delocalized into the heterocyclic rings. However, a change to marked pyramidality of the amino group (N then sp 3 hybridized, lone pair essentially localized at N) occurs during i) involvement of an amino proton in strong hydrogen bonding donor conditions or ii) with monofunctional metal coordination following removal of one of the ...
Tópico(s): RNA and protein synthesis mechanisms
2014 - Wiley | Chemistry - A European Journal
Alba Vellé, Andrea Cebollada, Manuel Iglesias, Pablo J. Sanz Miguel,
A cationic [Ag2(bis-NHC)2](2+) system behaves as an excellent host for Ag(+). In the solid-state variation, Ag···Ag are the only bonding interactions between host and guest, overcoming their inherent electrostatic repulsion. It represents a clear example of ligand-unsupported ("pure") argentophilicity. In solution, we also found evidence for this kind of Ag···Ag approximation, which might be recognized as an initial step of transmetalation mechanisms involving formally closed-shell metal centers as ...
Tópico(s): Asymmetric Hydrogenation and Catalysis
2014 - American Chemical Society | Inorganic Chemistry
Manuel Iglesias, Pablo J. Sanz Miguel, Víctor Polo, Francisco J. Fernández‐Álvarez, Jesús J. Pérez‐Torrente, Luis A. Oro,
The β-Z selectivity in the hydrosilylation of terminal alkynes has been hitherto explained by introduction of isomerisation steps in classical mechanisms. DFT calculations and experimental observations on the system [M(I)2{κ-C,C,O,O-(bis-NHC)}]BF4 (M=Ir (3a), Rh (3b); bis-NHC=methylenebis(N-2-methoxyethyl)imidazole-2-ylidene) support a new mechanism, alternative to classical postulations, based on an outer-sphere model. Heterolytic splitting of the silane molecule by the metal centre and acetone (solvent) ...
Tópico(s): Catalytic C–H Functionalization Methods
2013 - Wiley | Chemistry - A European Journal
Francisca M. Albertí, Witold Zieliński, M.M. Cerda, Pablo J. Sanz Miguel, Oliver Troeppner, Ivana Ivanović‐Burmazović, Bernhard Lippert,
Crossing the line: A pH-induced “crossover” in 3D shapes of supramolecular constructs derived from trans(NH3)2PtII, [PdII(en)], and the purine model nucleobase 9-methylhypoxanthine (see figure) is reported in which [Pd(en)(H2O)]2+ and [Pd(en)(OH)]+ are the decisive players (en=ethylenediamine).
Tópico(s): Nanocluster Synthesis and Applications
2013 - Wiley | Chemistry - A European Journal
Juan V. Alegre‐Requena, Eugenia Marqués‐López, Pablo J. Sanz Miguel, Raquel P. Herrera,
We report our results concerning the first squaramide-catalysed hydrophosphonylation of aldehydes. In all cases, the reactions proceeded smoothly and cleanly under mild reaction conditions rendering final α-hydroxy phosphonates in very good yields and high enantioselectivities. It is one of the few organocatalytic examples of this reaction using aldehydes. It is the first time that diphenylphosphite (1e) has been successfully employed in a chiral Pudovik reaction with aldehydes, in contrast to the ...
Tópico(s): Synthesis and Reactivity of Sulfur-Containing Compounds
2013 - Royal Society of Chemistry | Organic & Biomolecular Chemistry