Johanna Husmark, Nils‐Erik Heldin, Mikael Nilsson,
... SwedenSearch for more papers by this authorMikael Nilsson, Mikael Nilsson Institute of Anatomy and Cell Biology, Göteborg University, ... SwedenSearch for more papers by this authorMikael Nilsson, Mikael Nilsson Institute of Anatomy and Cell Biology, Göteborg University, ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
1999 - Wiley | International Journal of Cancer
Mikael Nilsson, Johanna Husmark, Bengt Nilsson, Lars‐Erik Tisell, Lars Ericson,
... such as autoimmunity, cell transformation and tumor progression. Mikael Nilsson, Institute of Anatomy and Cell Biology, Göteborg University, ...
Tópico(s): Animal Genetics and Reproduction
1996 - Oxford University Press | European Journal of Endocrinology
Randy Ngelale, Christopher Lee, Steven Bustillos, Mikael Nilsson,
Randy Ngelalea, Christopher Leea, Steven Bustillosa & Mikael Nilsson*aba Department of Chemical Engineering and Material Science, University of California Irvine, Irvine, CA, USAb Department of Chemistry, University of California Irvine, ...
Tópico(s): Chemical Synthesis and Characterization
2018 - Taylor & Francis | Solvent Extraction and Ion Exchange
Mikael Nilsson, Mikael Widersten,
A single-chain derivative of the lambda Cro repressor (scCro) has been randomly mutated in amino acid residues critical for specific DNA recognition to create libraries of protein variants. Utilizing phage display-afforded affinity selection, scCro variants have been isolated for binding to synthetic DNA ligands. Isolated scCro variants were analyzed functionally, both in fusion with phage particles and after expression of the corresponding free proteins. The binding properties with regard to specificity ...
Tópico(s): Glycosylation and Glycoproteins Research
2004 - American Chemical Society | Biochemistry
Jens Malmodin, Dag Lundén, Åsa Moberg, Greger Andersson, Mikael Nilsson,
Summary The use of information and communication technology (ICT) is growing throughout society, and new products and solutions are developed at an increasing rate. To enable environmental assessment of specific ICT products and other products that rely on ICT in some way, a more complete, detailed, and up‐to‐date study based on real measurements is needed. To date, similar studies have not been readily available or fully comprehensive. This study assessed the overall operational electricity use ...
Tópico(s): Recycling and Waste Management Techniques
2014 - Wiley | Journal of Industrial Ecology
Bruce J. Mincher, Stephen P. Mezyk, Gracy Elias, Gary S. Groenewold, Jay A. LaVerne, Mikael Nilsson, Jeremy D. Pearson, Nicholas C. Schmitt, Richard D. Tillotson, Lonnie G. Olson,
Abstract Octylphenyl-N,N-diisobutylcarbamoylmethylphosphine oxide (CMPO) dissolved in dodecane was subjected to α-irradiation using a He-ion beam, 244 Cm isotopic α-rays, and He and Li ions created by the n,α reaction of 10B in a nuclear reactor. Post-irradiation samples were analyzed for the radiolytically-induced decrease in CMPO concentration, the appearance of degradation products, and their Am solvent extraction distribution ratios. The –G CMPO-value for the radiolytic degradation of CMPO was ...
Tópico(s): Analytical chemistry methods development
2014 - Taylor & Francis | Solvent Extraction and Ion Exchange
Jingfang Gao, Yihong Zhu, Mikael Nilsson, Karin Sundfeldt,
Transforming growth factor beta (TGF-β) plays major roles in tumorigenesis by regulating cell growth, epithelial-to-mesenchymal transition (EMT), migration/invasion and metastasis. The epithelial markers E-cadherin, claudin-3 and claudin-4, commonly decreased in human adenocarcinomas are actually up regulated during ovarian carcinogenesis. In human ovarian cancer TGF-β1 may either suppress or promote tumor progression, but whether other TGF-β isoforms (TGF-β2 and TGF-β3) exert similar effects is not ...
Tópico(s): Barrier Structure and Function Studies
2014 - BioMed Central | Cancer Cell International
Mikael Nilsson, Jonas Kvarnström, Patrick Doherty,
Simple Temporal Networks with Uncertainty (STNUs) allow the representation of temporal problems where some durations are determined by nature, as is often the case for actions in planning. As such networks are generated it is essential to verify that they are dynamically controllable -- executable regardless of the outcomes of uncontrollable durations -- and to convert them to a dispatchable form. The previously published FastIDC algorithm achieves this incrementally and can therefore be used efficiently ...
Tópico(s): Data Management and Algorithms
2013 - | Proceedings of the International Conference on Automated Planning and Scheduling
Ross J. Ellis, Timothy L. Anderson, Mark R. Antonio, Alex Braatz, Mikael Nilsson,
The macroscopic phase behaviors of a solvent system containing two extractants, tri-n-butyl phosphate (TBP) and di-n-butyl phosphoric acid (HDBP) in n-dodecane, were investigated through use of liquid–liquid extraction and small-angle X-ray scattering (SAXS) experiments. Five organic solutions, each containing a total extractant concentration (TBP + HDBP) of 1 M in varying molar ratios (0, 0.25, 0.5, 0.75, and 1.0 [TBP]:[TBP + HDBP]), were contacted with 0.2 M HNO3 aqueous solutions without and with dysprosium( ...
Tópico(s): Chemical and Physical Properties in Aqueous Solutions
2013 - American Chemical Society | The Journal of Physical Chemistry B
... The Structure of the Defense Industry, 171–77. Mikael Nilsson, Tools of Hegemony: Military Technology and Swedish-American ...
Tópico(s): Defense, Military, and Policy Studies
2013 - Taylor & Francis | Security Studies
Mikael Nilsson, Henrik Fagman,
Thyroid dysgenesis is the most common cause of congenital hypothyroidism that affects 1 in 3000 newborns. Although a number of pathogenetic mutations in thyroid developmental genes have been identified, the molecular mechanism of disease is unknown in most cases. This chapter summarizes the current knowledge of normal thyroid development and puts the different developmental stages in perspective, from the time of foregut endoderm patterning to the final shaping of pharyngeal anatomy, for understanding ...
Tópico(s): Genetic Syndromes and Imprinting
2013 - Elsevier BV | Current topics in developmental biology/Current Topics in Developmental Biology
Timothy L. Anderson, Alex Braatz, Ross J. Ellis, Mark R. Antonio, Mikael Nilsson,
During treatment of nuclear fuel in the Plutonium/URanium EXtraction (PUREX) process, the extractant tri-n-butyl phosphate (TBP) is known to degrade to dibutylphosphoric acid (HDBP), which increases the extraction of metal ions, thereby inhibiting their stripping from the organic phase. To better understand this phenomenon, we investigated how mixtures of TBP and HDBP influenced the extraction of metal, nitric acid, and water, and correlated the results to aggregated structures in the organic phase. ...
Tópico(s): Chemical Synthesis and Characterization
2013 - Taylor & Francis | Solvent Extraction and Ion Exchange
Johan Gising, Mikael Nilsson, Luke R. Odell, Samir Yahiaoui, Martin Lindh, Harini Iyer, A M Sinha, B. R. Srinivasa, Mats Larhed, Sherry L. Mowbray, Anders Karlén,
Mycobacterium tuberculosis glutamine synthetase (MtGS) is a promising target for antituberculosis drug discovery. In a recent high-throughput screening study we identified several classes of MtGS inhibitors targeting the ATP-binding site. We now explore one of these classes, the 2-tert-butyl-4,5-diarylimidazoles, and present the design, synthesis, and X-ray crystallographic studies leading to the identification of MtGS inhibitors with submicromolar IC(50) values and promising antituberculosis MIC ...
Tópico(s): Tuberculosis Research and Epidemiology
2012 - American Chemical Society | Journal of Medicinal Chemistry
Mikael Nilsson, Jan Östergren, Uno Fors, Anette Rickenlund, L. Jorfeldt, Kenneth Caidahl, Gunilla Bolinder,
The compressed curriculum in modern knowledge-intensive medicine demands useful tools to achieve approved learning aims in a limited space of time. Web-based learning can be used in different ways to enhance learning. Little is however known regarding its optimal utilisation. Our aim was to investigate if the individual learning styles of medical students influence the choice to use a web-based ECG learning programme in a blended learning setting.The programme, with three types of modules (learning ...
Tópico(s): Evaluation of Teaching Practices
2012 - BioMed Central | BMC Medical Education
Michael Lempart, H. Benedek, Christian Jamtheim Gustafsson, Mikael Nilsson, Niklas Eliasson, Sven Bäck, Per Munck af Rosenschöld, Lars Olsson,
Background and purposeRadiation therapy treatment planning is a manual, time-consuming task that might be accelerated using machine learning algorithms. In this study, we aimed to evaluate if a triplet-based deep learning model can predict volumetric modulated arc therapy (VMAT) dose distributions for prostate cancer patients.Materials and methodsA modified U-Net was trained on triplets, a combination of three consecutive image slices and corresponding segmentations, from 160 patients, and compared ...
Tópico(s): Advanced X-ray and CT Imaging
2021 - Elsevier BV | Physics and Imaging in Radiation Oncology
Katarina Howner, Peter Andiné, Göran Engberg, Emin Hoxha Ekström, Eva Lindström, Mikael Nilsson, Susanna Radovic, Monica Hultcrantz,
Background Pharmacological treatment is of great importance in forensic psychiatry, and the vast majority of patients are treated with antipsychotic agents. There are several systematic differences between general and forensic psychiatric patients, e.g. severe violent behavior, the amount of comorbidity, such as personality disorders and/or substance abuse. Based on that, it is reasonable to suspect that effects of pharmacological treatments also may differ. The objective of this systematic review ...
Tópico(s): Treatment of Major Depression
2020 - Frontiers Media | Frontiers in Psychiatry
Eric Montoya, Jen-Ru Chen, Randy Ngelale, Han Kyu Lee, Hsin-wei Tseng, Lei Wan, En Yang, P. M. Braganca, Ozdal Boyraz, Nader Bagherzadeh, Mikael Nilsson, I. N. Krivorotov,
Abstract Spin transfer torque magnetic random access memory (STT-MRAM) is a promising candidate for next generation memory as it is non-volatile, fast, and has unlimited endurance. Another important aspect of STT-MRAM is that its core component, the nanoscale magnetic tunneling junction (MTJ), is thought to be radiation hard, making it attractive for space and nuclear technology applications. However, studies on the effects of ionizing radiation on the STT-MRAM writing process are lacking for MTJs ...
Tópico(s): Magneto-Optical Properties and Applications
2020 - Nature Portfolio | Scientific Reports
Jan Pawlas, Timo Nuijens, Jonas Persson, Thomas Svensson, Marcel Schmidt, Ana Toplak, Mikael Nilsson, Jon H. Rasmussen,
Exemplified by antidiabetic exenatide CEPS provides a highly efficient, easily scalable biocatalytic route to manufacture therapeutic peptides.
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2019 - Royal Society of Chemistry | Green Chemistry
Mikael Nilsson, Carl Gustafson, Taimoor Abbas, Fredrik Tufvesson,
The non line-of-sight (NLOS) scenario in urban intersections is critical in terms of traffic safety-a scenario where Vehicle-to-Vehicle (V2V) communication really can make a difference by enabling communication and detection of vehicles around building corners. A few NLOS V2V channel models exist in the literature but they all have some form of limitation, and therefore further research is need. In this paper, we present an alternative NLOS path loss model based on analysis from measured V2V communication ...
Tópico(s): Autonomous Vehicle Technology and Safety
2018 - Multidisciplinary Digital Publishing Institute | Sensors
Alan Tam, Ozdal Boyraz, Jaclynn Unangst, Philip Nazareta, Michael A. Schreuder, Mikael Nilsson,
Scintillation and luminescence enhancement were observed in a Quantum Dot-doped scintillating polymer, facilitating energy transfer with polymer medium and scintillating dye. 2,5-diphenyloxazole (PPO) and Cadmium Sulfide (CdS) Quantum Dots (QD) with 418 nm emission coated with oleic acid were dispersed in a polyvinyl toluene (PVT) matrix with transparency retained. Under UV excitation a sharp emission was detected at 426 nm from minimal QD loading with possible indication of QD energy transfer. Scintillation ...
Tópico(s): Atomic and Subatomic Physics Research
2018 - Elsevier BV | Radiation Measurements
Álfheiður Ástvaldsdóttir, Anne‐Marie Boström, Thomas Davidson, Pia Gabre, Lars Gahnberg, Gunilla Sandborgh‐Englund, Pia Skott, Katri Ståhlnacke, Sofia Tranæus, Hanna Wilhelmsson, Inger Wårdh, Pernilla Östlund, Mikael Nilsson,
Objectives To examine the current knowledge on oral health status and dental care of older persons through a systematic mapping of systematic reviews of low or moderate risk of bias. Background Geriatric dentistry covers all aspects of oral health and oral care of older persons. Oral health is part of general health and contributes to a person's physical, psychological and social wellbeing. Methods A literature search was performed in three different databases (PubMed, The Cochrane Library and Cinahl) ...
Tópico(s): Dysphagia Assessment and Management
2018 - Wiley | Gerodontology
Oleksiy Guzhva, Håkan Ardö, Mikael Nilsson, Anders Herlin, Linda Tufvesson,
To maintain dairy cattle health and welfare at commensurable levels, analysis of the behaviours occurring between cows should be performed. This type of behavioural analysis is highly dependent on reliable and robust tracking of individuals, for it to be viable and applicable on-site. In this article, we introduce a novel method for continuous tracking and data-marker based identification of individual cows based on convolutional neural networks (CNNs). The tracker optimises over the sequences of ...
Tópico(s): Food Supply Chain Traceability
2018 - Frontiers Media | Frontiers in Robotics and AI
Shawn Liang, Ellen Johansson, Guillermo Barila, Daniel L. Altschuler, Henrik Fagman, Mikael Nilsson,
ABSTRACT The developmental program that regulates thyroid progenitor cell proliferation is largely unknown. Here, we show that branching-like morphogenesis is a driving force to attain final size of the embryonic thyroid gland in mice. Sox9, a key factor in branching organ development, distinguishes Nkx2-1+ cells in the thyroid bud from the progenitors that originally form the thyroid placode in anterior endoderm. As lobes develop the thyroid primordial tissue branches several generations. Sox9 ...
Tópico(s): Animal Genetics and Reproduction
2017 - The Company of Biologists | Development
Mikael Nilsson, Carl Gustafson, Taimoor Abbas, Fredrik Tufvesson,
Shadowing from vehicles can significantly degrade the performance of vehicle-to-vehicle (V2V) communication in multilink systems, e.g., vehicular ad hoc networks (VANETs). It is, thus, important to characterize and model the influence of common shadowing objects like cars properly when designing these VANETs. Despite the fact that for multilink systems it is essential to model the joint effects on the different links, the multilink shadowing effects of V2V channels on VANET simulations are not yet ...
Tópico(s): Traffic control and management
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Vehicular Technology
Ko Nee, Samuel A. Bryan, Tatiana G. Levitskaia, Jennifer W.-J. Kuo, Mikael Nilsson,
The reliability of chemical processes can be greatly improved by implementing inline monitoring systems. Combining multivariate analysis with non-destructive sensors can enhance the process without interfering with the operation. We present here hierarchical models using both principal component analysis and partial least square analysis developed for different chemical components representative of solvent extraction process streams. A training set of 380 samples and an external validation set of ...
Tópico(s): Spectroscopy Techniques in Biomedical and Chemical Research
2017 - Elsevier BV | Analytica Chimica Acta
Mikael Nilsson, Henrik Fagman,
Thyroid hormones are crucial for organismal development and homeostasis. In humans, untreated congenital hypothyroidism due to thyroid agenesis inevitably leads to cretinism, which comprises irreversible brain dysfunction and dwarfism. Elucidating how the thyroid gland – the only source of thyroid hormones in the body – develops is thus key for understanding and treating thyroid dysgenesis, and for generating thyroid cells in vitro that might be used for cell-based therapies. Here, we review the principal ...
Tópico(s): Renal and related cancers
2017 - The Company of Biologists | Development
Leif Lindström, Eva Lindström, Mikael Nilsson, Malin Höistad,
Second generations antipsychotics (SGA) are frequently used for maintenance treatment in bipolar disorder. We systematically reviewed the efficacy and long-term effects of treatment with SGA, regardless of treatment strategy (SGA administered either as monotherapy or as adjunctive therapy), in comparison to placebo, lithium or valproate. Primary outcomes were relapses (mood episode recurrence) and discontinuation. Clinical studies were identified through database searching in PubMed, Embase, PsychInfo ...
Tópico(s): Coordination Chemistry and Organometallics
2017 - Elsevier BV | Journal of Affective Disorders
Håkan Ardö, Oleksiy Guzhva, Mikael Nilsson, Anders Herlin,
In the field of applied animal behaviour, video recordings of a scene of interest are often made and then evaluated by experts. This evaluation is based on different criteria (number of animals present, an occurrence of certain interactions, the proximity between animals and so forth) and aims to filter out video sequences that contain irrelevant information. However, such task requires a tremendous amount of time and resources, making manual approach ineffective. To reduce the amount of time the ...
Tópico(s): Animal Vocal Communication and Behavior
2017 - Institution of Engineering and Technology | IET Computer Vision
Mikael Nilsson, Dillwyn Williams,
We will highlight and put into perspective new lineage tracing data from genetic studies in mice indicating that the genuine progenitors to C cells arise in the endoderm germ layer. This overturns the current concept of a neural crest origin of thyroid C cells referred to in every textbook and dedicated paper to this very day. As will become apparent, except for a single experiment, the neural crest theory has little or no support when the evolution and development of calcitonin-producing cells ...
Tópico(s): FOXO transcription factor regulation
2016 - | European Thyroid Journal
Alexander Braatz, Mark R. Antonio, Mikael Nilsson,
The coordination of the trivalent 4f ions, Ln = La 3+ , Dy 3+ , and Lu 3+ , with neutral and acidic organophosphorus reagents, both individually and combined, was studied by use of X-ray absorption spectroscopy.
Tópico(s): Analytical chemistry methods development
2016 - Royal Society of Chemistry | Dalton Transactions