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Artigo Acesso aberto Revisado por pares

Mikkel Malling Beck, Rune Rasmussen Lind, Svend Sparre Geertsen, Christian Ritz, Jesper Lundbye‐Jensen, Jacob Wienecke,

Objective: An emerging field of research indicates that physical activity can benefit cognitive functions and academic achievements in children. However, less is known about how academic achievements can benefit from specific types of motor activities (e.g. fine and gross) integrated into learning activities. Thus, the aim of this study was to investigate whether fine or gross motor activity integrated into math lessons (i.e. motor-enrichment) could improve children’s mathematical performance. Methods: ...

Tópico(s): Cognitive and developmental aspects of mathematical skills

2016 - Frontiers Media | Frontiers in Human Neuroscience

Artigo Acesso aberto Revisado por pares

Richard Thomas, Mikkel Malling Beck, Rune Rasmussen Lind, Line Korsgaard Johnsen, Svend Sparre Geertsen, Lasse Christiansen, Christian Ritz, Marc Roig, Jesper Lundbye‐Jensen,

High intensity aerobic exercise amplifies offline gains in procedural memory acquired during motor practice. This effect seems to be evident when exercise is placed immediately after acquisition, during the first stages of memory consolidation, but the importance of temporal proximity of the exercise bout used to stimulate improvements in procedural memory is unknown. The effects of three different temporal placements of high intensity exercise were investigated following visuomotor skill acquisition ...

Tópico(s): Creativity in Education and Neuroscience

2016 - Hindawi Publishing Corporation | Neural Plasticity

Revisão Acesso aberto Revisado por pares

Lasse Christiansen, Mikkel Malling Beck, Niels Bilenberg, Jacob Wienecke, Arne Astrup, Jesper Lundbye‐Jensen,

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with a complex symptomatology, and core symptoms as well as functional impairment often persist into adulthood. Recent investigations estimate the worldwide prevalence of ADHD in children and adolescents to be ~7%, which is a substantial increase compared to a decade ago. Conventional treatment most often includes pharmacotherapy with central nervous stimulants, but the number of non-responders and adverse effects call ...

Tópico(s): Functional Brain Connectivity Studies

2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine

Artigo Acesso aberto Revisado por pares

Rune Rasmussen Lind, Mikkel Malling Beck, Johan Michael Wikman, Krzysztof Malarski, Peter Krustrup, Jesper Lundbye‐Jensen, Svend Sparre Geertsen,

Recent studies suggest that a single bout of exercise can lead to transient performance improvements in specific cognitive domains in children. However, more knowledge is needed to determine the key exercise characteristics for obtaining these effects and how they translate into real-world settings. In the present study, we investigate how small-sided football games of either high- or moderate-intensity affect measures of inhibitory control in a school setting. Eighty-one children (mean age 11.8, ...

Tópico(s): Motivation and Self-Concept in Sports

2019 - Wiley | Scandinavian Journal of Medicine and Science in Sports

Artigo Acesso aberto Revisado por pares

Lasse Christiansen, Richard Thomas, Mikkel Malling Beck, Jessica Pingel, Jeppe Dyrberg Andersen, Cameron S. Mang, Mads A.J. Madsen, Marc Roig, Jesper Lundbye‐Jensen,

When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed to investigate the influence of dopaminergic pathways on the exercise-induced modulation of motor memory consolidation. We compared the effect of acute exercise on motor memory consolidation between ...

Tópico(s): Sleep and Wakefulness Research

2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine

Artigo Acesso aberto Revisado por pares

Tomofumi Yamaguchi, Mikkel Malling Beck, Eva Rudjord Therkildsen, Christian Svane, Christian Riis Forman, Jakob Lorentzen, B. Conway, Jesper Lundbye‐Jensen, Svend Sparre Geertsen, Jens Bo Nielsen,

Optimization of motor performance is of importance in daily life, in relation to recovery following injury as well as for elite sports performance. The present study investigated whether transcutaneous spinal direct current stimulation (tsDCS) may enhance voluntary ballistic activation of ankle muscles and descending activation of spinal motor neurons in able-bodied adults. Forty-one adults (21 men; 24.0 ± 3.2 years) participated in the study. The effect of tsDCS on ballistic motor performance and plantar ...

Tópico(s): Spinal Cord Injury Research

2020 - Wiley | Physiological Reports

Artigo Acesso aberto Revisado por pares

Mikkel Malling Beck, Meaghan Elizabeth Spedden, Jesper Lundbye‐Jensen,

Abstract How does the neural control of fine movements develop from childhood to adulthood? Here, we investigated developmental differences in functional corticomuscular connectivity using coherence analyses in 111 individuals from four different age groups covering the age range 8–30 y. EEG and EMG were recorded while participants performed a uni-manual force-tracing task requiring fine control of force in a precision grip with both the dominant and non-dominant hand. Using beamforming methods, ...

Tópico(s): EEG and Brain-Computer Interfaces

2021 - Nature Portfolio | Scientific Reports

Revisão Acesso aberto Revisado por pares

Hartwig R. Siebner, Klaus Funke, Aman S. Aberra, Andrea Antal, Sven Bestmann, Robert Chen, Joseph Claßen, Marco Davare, Vincenzo Di Lazzaro, Peter T. Fox, Mark Hallett, Anke Ninija Karabanov, Janine Kesselheim, Mikkel Malling Beck, Giacomo Koch, David Liebetanz, Sabine Meunier, Carlo Miniussi, Walter Paulus, Angel V. Peterchev, Traian Popa, Michael C. Ridding, Axel Thielscher, Ulf Ziemann, John C. Rothwell, Yoshikazu Ugawa,

Transcranial (electro)magnetic stimulation (TMS) is currently the method of choice to non-invasively induce neural activity in the human brain. A single transcranial stimulus induces a time-varying electric field in the brain that may evoke action potentials in cortical neurons. The spatial relationship between the locally induced electric field and the stimulated neurons determines axonal depolarization. The induced electric field is influenced by the conductive properties of the tissue compartments ...

Tópico(s): Vestibular and auditory disorders

2022 - Elsevier BV | Clinical Neurophysiology

Artigo Acesso aberto Revisado por pares

Tomofumi Yamaguchi, Christian Svane, Christian Riis Forman, Mikkel Malling Beck, Svend Sparre Geertsen, Jesper Lundbye‐Jensen, Jens Bo Nielsen,

Consolidation leading to retention of motor memory following motor practice involves activity-dependent plastic processes in the corticospinal system. To investigate whether beta-band transcranial alternating current stimulation (tACS) applied immediately following skill acquisition can enhance ongoing consolidation processes and thereby motor skill retention 20 adults participated in a randomized, double-blinded, sham-controlled study. Participants received tACS at peak beta-band corticomuscular ...

Tópico(s): Motor Control and Adaptation

2020 - Oxford University Press | Cerebral Cortex Communications

Artigo Acesso aberto Revisado por pares

Meaghan Elizabeth Spedden, Mikkel Malling Beck, Mark Schram Christensen, Martin Dietz, Anke Ninija Karabanov, Svend Sparre Geertsen, Jens Bo Nielsen, Jesper Lundbye‐Jensen,

The control of ankle muscle force is an integral component of walking and postural control. Aging impairs the ability to produce force steadily and accurately, which can compromise functional capacity and quality of life. Here, we hypothesized that reduced force control in older adults would be associated with altered cortico-cortical communication within a network comprising the primary motor area (M1), the premotor cortex (PMC), parietal, and prefrontal regions. We examined electroencephalographic ( ...

Tópico(s): Balance, Gait, and Falls Prevention

2020 - Elsevier BV | NeuroImage

Artigo Revisado por pares

Carla Centeno, Diogo Medeiros, Mikkel Malling Beck, Liav Lugassy, David Fernandez Gonzalez, Jean-François Nepveu, Marc Roig,

We investigated whether cortico-spinal excitability (CSE), a marker of synaptic plasticity, is associated with age-related differences in the consolidation of motor memory. Young and older participants practiced a visuomotor tracking task. Skill retention was assessed 8 and 24 hours after motor practice. Transcranial magnetic stimulation applied over the primary motor cortex at rest and during an isometric muscle contraction was used to assess absolute and normalized to baseline CSE at different ...

Tópico(s): Muscle activation and electromyography studies

2018 - Elsevier BV | Neurobiology of Aging

Artigo Revisado por pares

Mikkel Malling Beck, Marcus Udsen Grandjean, Sander Hartmand, Meaghan Elizabeth Spedden, Lasse Christiansen, Marc Roig, Jesper Lundbye‐Jensen,

Acute cardiovascular exercise can promote motor memory consolidation following motor practice, and thus long-term retention, but the underlying mechanisms remain sparsely elucidated. Here we test the hypothesis that the positive behavioral effects of acute exercise involve the primary motor cortex and the corticospinal pathway by interfering with motor memory consolidation using non-invasive, low frequency, repetitive transcranial magnetic stimulation (rTMS). Forty-eight able-bodied, young adult ...

Tópico(s): Muscle activation and electromyography studies

2020 - Elsevier BV | Neuroscience

Artigo Acesso aberto Revisado por pares

Mikkel Malling Beck, Meaghan Elizabeth Spedden, Martin Dietz, Anke Ninija Karabanov, Mark Schram Christensen, Jesper Lundbye‐Jensen,

Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous control, we analyzed electroencephalographic data from 88 individuals (range 8-30 years) performing a visually guided precision grip task using dynamic causal modelling and parametric empirical Bayes. ...

Tópico(s): EEG and Brain-Computer Interfaces

2021 - eLife Sciences Publications Ltd | eLife

Artigo Revisado por pares

Stefan Grau, Otto Müller, W. Bäurle, Mikkel Malling Beck, Inga Krauß, Christian Maiwald, Heiner Baur, F. Mayer,

Mittels der Videoanalyse wird in der Regel die dreidimensionale Bewegung der unteren Extremität beim Abrollvorgang evaluiert. Überwiegend erfolgt diese Analyse zweidimensional in der Frontalebene oder der Sagittalebene. In der Regel werden vor allem der zeitliche Verlauf des Achillessehnen- bzw. Rückfußwinkels in der Frontalebene und des Knie- und OSG-Winkels in der Sagittalebene analysiert, da deren Ausprägungsgrad für diverse Beschwerden im Sport verantwortlich gemacht wird. Dennoch konnte bisher ...

Tópico(s): Sports Performance and Training

2000 - Thieme Medical Publishers (Germany) | Sportverletzung · Sportschaden

Artigo Acesso aberto Revisado por pares

Meaghan Elizabeth Spedden, Mikkel Malling Beck, Timothy O. West, Simon F. Farmer, Jens Bo Nielsen, Jesper Lundbye‐Jensen,

Abstract The cortical mechanisms underlying the act of taking a step—including planning, execution, and modification—are not well understood. We hypothesized that oscillatory communication in a parieto-frontal and corticomuscular network is involved in the neural control of visually guided steps. We addressed this hypothesis using source reconstruction and lagged coherence analysis of electroencephalographic and electromyographic recordings during visually guided stepping and 2 control tasks that ...

Tópico(s): Functional Brain Connectivity Studies

2022 - Oxford University Press | Cerebral Cortex

Artigo Acesso aberto Revisado por pares

Patrick Wiegel, Meaghan Elizabeth Spedden, Christina Ramsenthaler, Mikkel Malling Beck, Jesper Lundbye‐Jensen,

The history of our actions and their outcomes represent important information, informing choices and efficiently guiding future behavior. While unsuccessful (S-) outcomes are expected to lead to more explorative motor states and increased behavioral variability, successful (S+) outcomes are expected to reinforce the use of the previous action. Here, we show that humans attribute different values to previous actions during reinforcement motor learning when they experience S- compared to S+ outcomes. ...

Tópico(s): EEG and Brain-Computer Interfaces

2022 - Elsevier BV | Neuroscience

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Lukas F. K. Kuderna, Jacob C. Ulirsch, Sabrina Mohd Rashid, Mohamed Ameen, Laksshman Sundaram, Glenn Hickey, Anthony J. Cox, Hong Gao, Arvind Kumar, François Aguet, Matthew J. Christmas, Hiram Clawson, Maximilian Haeussler, Mareike C. Janiak, Martin Kuhlwilm, Joseph D. Orkin, Thomas Bataillon, Shivakumara Manu, Alejandro Valenzuela, Juraj Bergman, Marjolaine Rouselle, Felipe Ennes Silva, Lídia Águeda, Julie Blanc, Marta Gut, Dorien de Vries, Ian Goodhead, R. Alan Harris, Muthuswamy Raveendran, Axel Jensen, Idriss S. Chuma, Julie E. Horvath, Christina Hvilsom, David Juan, Peter Frandsen, Joshua G. Schraiber, Fabiano Rodrigues de Melo, Fabrício Bertuol, Hazel Byrne, Iracilda Sampaio, Izeni Pires Farias, João Valsecchi, Malu Messias, Maria Nazareth Ferreira da Silva, Mihir Trivedi, Rogério Vieira Rossi, Tomas Hrbek, Nicole Andriaholinirina, C. Rabarivola, Alphonse Zaramody, Clifford J. Jolly, Jane E. Phillips‐Conroy, Gregory K. Wilkerson, Christian R. Abee, Joe H. Simmons, Eduardo Fernández‐Duque, Sree Kanthaswamy, Fekadu Shiferaw, Dong‐Dong Wu, Long Zhou, Yong Shao, Guojie Zhang, Julius D. Keyyu, Sascha Knauf, Minh Đức Lê, Esther Lizano, Stefan Merker, Arcadi Navarro, Tilo Nadler, Chiea Chuen Khor, Jessica Lee, Patrick Tan, Weng Khong Lim, Andrew C. Kitchener, Dietmar Zinner, Marta Gut, Amanda Melin, Katerina Guschanski, Mikkel Heide Schierup, Robin M. D. Beck, Ioannis Karakikes, Ke Wang, Govindhaswamy Umapathy, Christian Roos, Jean P. Boubli, Adam Siepel, Anshul Kundaje, Benedict Paten, Kerstin Lindblad‐Toh, Jeffrey Rogers, Tomás Marquès‐Bonet, Kyle Kai‐How Farh,

Abstract Noncoding DNA is central to our understanding of human gene regulation and complex diseases 1,2 , and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in the human genome 3–9 . Identifying the genomic elements that have become constrained specifically in primates has been hampered by the faster evolution of noncoding DNA compared to protein-coding DNA 10 , the relatively short timescales separating primate species 11 , and the ...

Tópico(s): RNA Research and Splicing

2023 - Nature Portfolio | Nature

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Hong Gao, Tobias Hamp, Jeffrey M. Ede, Joshua G. Schraiber, Jeremy F. McRae, Moriel Singer‐Berk, Yanshen Yang, Anastasia S. D. Dietrich, Petko Fiziev, Lukas F. K. Kuderna, Laksshman Sundaram, Yibing Wu, Aashish N. Adhikari, Yair Field, Chen Chen, Serafim Batzoglou, François Aguet, Gabrielle Lemire, Rebecca Reimers, Daniel J. Balick, Mareike C. Janiak, Martin Kuhlwilm, Joseph D. Orkin, Shivakumara Manu, Alejandro Valenzuela, Juraj Bergman, Marjolaine Rousselle, Felipe Ennes Silva, Lídia Águeda, Julie Blanc, Marta Gut, Dorien de Vries, Ian Goodhead, R. Alan Harris, Muthuswamy Raveendran, Axel Jensen, Idriss S. Chuma, Julie E. Horvath, Christina Hvilsom, David Juan, Peter Frandsen, Fabiano Rodrigues de Melo, Fabrício Bertuol, Hazel Byrne, Iracilda Sampaio, Izeni Pires Farias, João Valsecchi, Mariluce Rezende Messias, Maria Nazareth Ferreira da Silva, Mihir Trivedi, Rogério Vieira Rossi, Tomas Hrbek, Nicole Andriaholinirina, C. Rabarivola, Alphonse Zaramody, Clifford J. Jolly, Jane E. Phillips‐Conroy, Gregory K. Wilkerson, Christian R. Abee, Joe H. Simmons, Eduardo Fernández‐Duque, Sree Kanthaswamy, Fekadu Shiferaw, Dong‐Dong Wu, Long Zhou, Yong Shao, Guojie Zhang, Julius D. Keyyu, Sascha Knauf, Minh Đức Lê, Esther Lizano, Stefan Merker, Arcadi Navarro, Thomas Bataillon, Tilo Nadler, Chiea Chuen Khor, Jessica Lee, Patrick Tan, Weng Khong Lim, Andrew C. Kitchener, Dietmar Zinner, Marta Gut, Amanda Melin, Katerina Guschanski, Mikkel Heide Schierup, Robin M. D. Beck, Govindhaswamy Umapathy, Christian Roos, Jean P. Boubli, Monkol Lek, Shamil Sunyaev, Anne O’Donnell‐Luria, Heidi L. Rehm, Jinbo Xu, Jeffrey Rogers, Tomás Marquès‐Bonet, Kyle Kai‐How Farh,

Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtained whole-genome sequencing data for 809 individuals from 233 primate species and identified 4.3 million common protein-altering variants with orthologs in humans. We show that these variants can be inferred to have nondeleterious effects in humans based ...

Tópico(s): Genomic variations and chromosomal abnormalities

2023 - American Association for the Advancement of Science | Science

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Lukas F. K. Kuderna, Hong Gao, Mareike C. Janiak, Martin Kuhlwilm, Joseph D. Orkin, Thomas Bataillon, Shivakumara Manu, Alejandro Valenzuela, Juraj Bergman, Marjolaine Rousselle, Felipe Ennes Silva, Lídia Águeda, Julie Blanc, Marta Gut, Dorien de Vries, Ian Goodhead, R. Alan Harris, Muthuswamy Raveendran, Axel Jensen, Idrissa S. Chuma, Julie E. Horvath, Christina Hvilsom, David Juan, Peter Frandsen, Joshua G. Schraiber, Fabiano Rodrigues de Melo, Fabrício Bertuol, Hazel Byrne, Iracilda Sampaio, Izeni Pires Farias, João Valsecchi, Malu Messias, Maria Nazareth Ferreira da Silva, Mihir Trivedi, Rogério Vieira Rossi, Tomas Hrbek, Nicole Andriaholinirina, C. Rabarivola, Alphonse Zaramody, Clifford J. Jolly, Jane E. Phillips‐Conroy, Gregory K. Wilkerson, Christian R. Abee, Joe H. Simmons, Eduardo Fernández‐Duque, Sree Kanthaswamy, Fekadu Shiferaw, Dong‐Dong Wu, Long Zhou, Yong Shao, Guojie Zhang, Julius D. Keyyu, Sascha Knauf, Minh Đức Lê, Esther Lizano, Stefan Merker, Arcadi Navarro, Tilo Nadler, Chiea Chuen Khor, Jessica Lee, Patrick Tan, Weng Khong Lim, Andrew C. Kitchener, Dietmar Zinner, Marta Gut, Amanda Melin, Katerina Guschanski, Mikkel Heide Schierup, Robin M. D. Beck, Govindhaswamy Umapathy, Christian Roos, Jean P. Boubli, Jeffrey Rogers, Kyle Kai‐How Farh, Tomás Marquès‐Bonet,

The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact of genomic diversity on fundamental biological processes. Analysis of that diversity provides insight into long-standing questions in evolutionary and conservation biology and is urgent given severe threats these species are facing. Here, we present high-coverage whole-genome data from 233 primate species representing 86% of genera and all 16 families. This ...

Tópico(s): Chromosomal and Genetic Variations

2023 - American Association for the Advancement of Science | Science

Artigo Acesso aberto Revisado por pares

Mikkel Andreassen, Rikke Beck Jensen, Niels Jørgensen, Anders Juul,

GH activity may be involved in male reproductive function. A common genetic polymorphism in the gene encoding the GH receptor (GHR) results in deletion of the entire exon 3 sequence (GHRd3 isoform). The short GHRd3/d3 isoform seems more sensitive compared with full-length receptors (GHRfl/fl).TO INVESTIGATE THE ASSOCIATIONS BETWEEN GH ACTIVITY, EVALUATED BY EXON 3 GHR POLYMORPHISM, AND SERUM IGF1 VS REPRODUCTIVE HORMONES, SEMEN QUALITY, AND PRE- AND POSTNATAL GROWTH IN HEALTHY YOUNG MALES (N=838, MEAN ...

Tópico(s): Lipid metabolism and disorders

2014 - Oxford University Press | European Journal of Endocrinology

Artigo Acesso aberto Revisado por pares

Mikkel Vilmand, Iben Have Beck, Niels Bilenberg, Anna‐Maria Andersson, Anders Juul, Greet Schoeters, Henriette Boye, Hanne Frederiksen, Tina Kold Jensen,

Phthalates are endocrine disrupters used in a variety of consumer products. Human studies suggest an association between phthalate exposure and cognitive development but adverse effects of the recently introduced phthalate substitutes have only been sparsely studied.To investigate associations between prenatal and concurrent exposure to phthalates and IQ in 7-year-old children from the Odense Child Cohort.Pregnant women from the Odense Child Cohort had phthalate metabolites measured in urine samples ...

Tópico(s): Health, Environment, Cognitive Aging

2023 - Elsevier BV | Neurotoxicology and Teratology

Artigo Acesso aberto Revisado por pares

Mikkel Malling Beck, Lasse Christiansen, Mads A.J. Madsen, Armita Faghani Jadidi, Mikkel C. Vinding, Axel Thielscher, Til Ole Bergmann, Hartwig R. Siebner, Leo Tomasevic,

Transcranial evoked potentials (TEPs) measured via electroencephalography (EEG) are widely used to study the cortical responses to transcranial magnetic stimulation (TMS). Immediate transcranial evoked potentials (i-TEPs) have been obscured by pulse and muscular artifacts. Thus, the TEP peaks that are commonly reported have latencies that are too long to be caused by direct excitation of cortical neurons.

Tópico(s): EEG and Brain-Computer Interfaces

2024 - Elsevier BV | Brain stimulation

Artigo Acesso aberto Revisado por pares

Jonas Rud Bjørndal, Mikkel Malling Beck, Lasse Jespersen, Lasse Christiansen, Jesper Lundbye‐Jensen,

Motor learning relies on experience-dependent plasticity in relevant neural circuits. In four experiments, we provide initial evidence and a double-blinded, sham-controlled replication (Experiment I-II) demonstrating that motor learning involving ballistic index finger movements is improved by preceding paired corticospinal-motoneuronal stimulation (PCMS), a human model for exogenous induction of spike-timing-dependent plasticity. Behavioral effects of PCMS targeting corticomotoneuronal (CM) synapses ...

Tópico(s): Transcranial Magnetic Stimulation Studies

2024 - Nature Portfolio | Nature Communications

Artigo Acesso aberto Revisado por pares

Lasse Jespersen, Katrine Matlok Maes, Nicoline Ardenkjær-Skinnerup, Marc Roig, Jonas Rud Bjørndal, Mikkel Malling Beck, Jesper Lundbye‐Jensen,

Performing a single bout of exercise can enhance motor learning and long-term retention of motor skills. Parameters such as the intensity and when the exercise bout is performed in relation to skill practice (i.e., timing) likely influence the effectiveness. However, it is still not fully understood how exercise should be administered to maximize its effects and how exercise interacts with distinct components of skill learning. Here, we expand this knowledge by investigating the potential synergistic ...

Tópico(s): Sport Psychology and Performance

2023 - Elsevier BV | Neurobiology of Learning and Memory

Artigo Revisado por pares

Edgaras Stankevıčıus, Thomas Dalsgaard, Christel Krøigaard, Lilliana Beck, Ebbe Boedtkjer, Mikkel Misfeldt, Gorm Nielsen, Olav L. Schjørring, Alun D. Hughes, Ulf Simonsen,

This study was designed to investigate whether calcium-activated potassium channels of small (SK Ca or K Ca 2) and intermediate (IK Ca or K Ca 3.1) conductance activated by 6,7-dichloro-1 H -indole-2,3-dione 3-oxime (NS309) are involved in both nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-type relaxation in large and small rat mesenteric arteries. Segments of rat superior and small mesenteric arteries were mounted in myographs for functional studies. NO was recorded using NO ...

Tópico(s): Renin-Angiotensin System Studies

2011 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics

Artigo Acesso aberto Revisado por pares

Alexander Perzylo, Markus Rickert, Björn Kahl, Nikhil Somani, Christian Lehmann, Alexander Kuss, Stefan Profanter, Anders Billesø Beck, Mathias Haage, Mikkel Rath Hansen, Malene Tofveson Nibe, Máximo A. Roa, Olof Sörnmo, Sven Gestegård Robertz, Ulrike Thomas, Germano Veiga, Elin Anna Topp, Ingmar Kessler, Marinus Danzer,

Current market demands require an increasingly agile production environment throughout many manufacturing branches. Traditional automation systems and industrial robots, on the other hand, are often too inflexible to provide an economically viable business case for companies with rapidly changing products. The introduction of cognitive abilities into robotic and automation systems is, therefore, a necessary step toward lean changeover and seamless human-robot collaboration.

Tópico(s): Robot Manipulation and Learning

2019 - Institute of Electrical and Electronics Engineers | IEEE Robotics & Automation Magazine

Artigo Acesso aberto Revisado por pares

Jeanette Tinggaard, Casper P. Hagen, Anders Nymark Christensen, Annette Mouritsen, Mikkel G. Mieritz, Christine Wohlfahrt‐Veje, Jørn Wulff Helge, Thomas Beck, Eva Fallentin, Rasmus Larsen, Rikke Beck Jensen, Anders Juul, Katharina M. Main,

Abdominal fat distribution is associated with the development of cardio-metabolic disease independently of body mass index (BMI). We assessed anthropometry, serum adipokines, and DXA as markers of abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) using magnetic resonance imaging (MRI). We performed a cross-sectional study that included 197 healthy adolescents (114 boys) aged 10–15 years nested within a longitudinal population-based cohort. Clinical examination, blood sampling, ...

Tópico(s): Obesity, Physical Activity, Diet

2017 - Springer Nature | Pediatric Research

Artigo Acesso aberto Revisado por pares

Aino Leegaard Andersen, Morten Baltzer Houlind, Rikke Lundsgaard Nielsen, Lillian Mørch Jørgensen, Charlotte Treldal, Morten Damgaard, Anne Kathrine Bengaard, Helle Gybel Juul‐Larsen, Louise Laursen, Esben Iversen, Marie Kruse, Anne Marie Lynge Pedersen, Mads Hornum, Anne Marie Beck, Mette Merete Pedersen, Mikkel Zöllner Ankarfeldt, Janne Petersen, Ove Andersen,

Internationally, older patients (≥65 years) account for more than 40% of acute admissions. Older patients admitted to the emergency department (ED) are frequently malnourished and exposed to inappropriate medication prescribing, due in part to the inaccuracy of creatinine-based equations for estimated glomerular filtration rate (eGFR). The overall aims of this trial are to investigate: (1) the efficacy of a medication review (MED intervention) independent of nutritional status, (2) the accuracy of eGFR ...

Tópico(s): Esophageal and GI Pathology

2021 - Springer Science+Business Media | Trials