Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin V. Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk Lindemann, Claire da Silva Santos, Kévin Tartour, Andrea Cimarelli, Rya Burdick, Jianbo Chen, Jaya Sastri, Wei-Shau Hu, Vinay K. Pathak, Oliver T. Keppler, Karine Pradeau, Sylvia Eiler, Nicolas Lévy, Sarah Lennon, Sarah Cianférani, Stéphane Emiliani, Marc Ruff, Vincent Parissi, Sylvie Rato, Antonio Rausell, Miguel Muñoz, Amalio Telenti, Angela Ciuffi, Alexander Zhyvoloup, Anat Melamed, I.G. Anderson, Delphine Planas, Janos Kriston‐Vizi, Robin Ketteler, Chen- Hsuin Lee, Andy Merritt, Petronela Ancuța, Charles R. M. Bangham, Ariberto Fassati, Anthony Rodari, Benoît Van Driessche, Mathilde Galais, Nadège Delacourt, Sylvain Fauquenoy, Caroline Vanhulle, Anna Kula, Arsène Burny, Olivier Rohr, Carine Van Lint, Thijs van Montfort, Renee van der Sluis, Dave Speijer, Ben Berkhout, Bo Meng, Andrzej Rutkowski, Neil Berry, Lars Dölken, Andrew Lever, Thomas Schuster, Benedikt Asbach, Ralf Wagner, Gross Christine, Veit Wiesmann, Martina Kalmer, Thomas Wittenberg, Jan Gettemans, Andrea K. Thoma‐Kress, Minghua Li, Eric O. Freed, Shan‐Lu Liu, J.Y. Muller, Jan Münch, Xaver Sewald, Pradeep D. Uchil, Mark S. Ladinsky, Jagadish Beloor, Ruoxi Pi, Christin Herrmann, Nasim Motamedi, Thomas T. Murooka, Michael A. Brehm, Dale L. Greiner, Thorsten R. Mempel, Pamela J. Björkman, Priti Kumar, Walther Mothes, Simone Joas, Erica H. Parrish, Clement W. Gnanadurai, Edina Lump, Christina M. Stürzel, Nicholas F. Parrish, Ulrike Sauermann, Katharina Töpfer, Tina Schultheiss, Steven E. Bosinger, Guido Silvestri, Cristian Apetrei, N. Huot, Michaela Müller‐Trutwin, Daniel Sauter, Beatrice H. Hahn, Christiane Stahl‐Hennig, Frank Kirchhoff, Gerald G. Schumann, Sabine Jung‐Klawitter, Nina V. Fuchs, Kyle R. Upton, Martín Muñoz-López, Ruchi Shukla, Jichang Wang, Marta García-Cañadas, Cesar Lopez‐Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundžija, Patricia Gerdes, Sylvia Merkert, Andrés Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, J.V. García‐Pérez, Geoffrey J. Faulkner, Tara Hurst, Aris Katzourakis, Gkikas Magiorkinis, Kerstin Schott, Rita Derua, Janna Seifried, Andreas Reuter, Heike Schmitz, Christiane Tondera, Alberto Brandariz-Núñez, Felipe Diaz‐Griffero, Veerle Janssens, Renate König, Hanna‐Mari Baldauf, Lena Stegmann, Sarah-Marie Schwarz, Maud Trotard, Margarethe Martin, Gina Lenzi, Manja Burggraf, Xiaoyu Pan, Oliver I. Fregoso, Efrem S. Lim, Libin Abraham, Elina Erikson, Laura Nguyen, Ina Ambiel, Frank Rutsch, Baek Kim, Michael Emerman, O. Fackler, Sabine Wittmann, Rayk Behrendt, Bianca Volkmann, Kristin Eissmann, Thomas Gramberg, Sebastian Bolduan, Herwig Koppensteiner, Stefanie Regensburg, Ruth Brack‐Werner, Rika Draenert, Michael Schindler, Aurélie Ducroux, Shuting Xu, Aparna Ponnurangam, Sergej Franz, Angelina Malassa, Ellen Ewald, Christine Goffinet, Sin‐Yee Fung, Ching-Ping Chan, Chun‐Kit Yuen, Kin‐Hang Kok, Chin-Ping Chan, Dong‐Yan Jin, Ulf Dittmer, Dorota Kmieć, Shilpa Iyer, Christina M. Stürzel, Beatrice H. Hahn, Yasuo Ariumi, Mariko Yasuda-Inoue, Koudai Kawano, Satoshi Tateishi, Priscilla Turelli, Alex Compton, Nicolas Roy, Françoise Porrot, Anne Billet, Nicoletta Casartelli, Jacob S. Yount, Liang Chen, Oliver Schwartz, Carsten Magnus, Lucia Reh, Penny L. Moore, Therese Uhr, Jacqueline Weber, Lynn Morris, Alexandra Trkola, Rashel V. Grindberg, Erika Schlaepfer, Gideon Schreiber, Viviana Simon, Roberto F. Speck, Zeger Debyser, Lenard Vranckx, Jonas Demeulemeester, Suha Saleh, Eric Verdin, Anna Cereseto, Frauke Christ, Rik Gijsbers, Gang Wang, Na Zhao, Atze T. Das, Josef Köstler, Beatriz Perdiguero, Mariano Estéban, Bertram L. Jacobs, David C. Montefiori, Celia C. LaBranche, Nicole L. Yates, Georgia D. Tomaras, Guido Ferrari, Kathryn E. Foulds, Mario Roederer, Gary Landucci, Donald N. Forthal, Michael S. Seaman, Natalie Hawkins, Steven G. Self, Sanjay Phogat, James Tartaglia, Susan W. Barnett, Brian Burke, Anthony D. Cristillo, Song Ding, Jonathan L. Heeney, Giuseppe Pantaleo, Viktoria Stab, Armin Ensser, Bettina Tippler, D. Jeff Burton, Matthias Tenbusch, Klaus Überla, Galit Alter, Giuseppe Lofano, Anne‐Sophie Dugast, Viraj Kulkarni, Todd J. Suscovich, Tatiana Opazo, Felipe Barraza, Diego Herrera, Andrea Garcés, Tomas Schwenke, Diego León Tapia, Jorge Cancino, Gloria Arriagada, Christina Haußner, Dominik Damm, Anette Rohrhofer, Bárbara Schmidt, Jutta Eichler, Rebecca J. Midgley, J. Wheeldon, Vincent Piguet, Priyanka Khopkar-Kale, Megha Rohamare, Smita Kulkarni, Ana Godinho‐Santos, Allan J. Hance, João Gonçalves, Fabrizio Mammano, Romain Gasser, Meriem Hamoudi, Martina Pellicciotta, Zhicheng Zhou,
... retroelement integrations in human genome Alexander Komkov, Anastasia Minervina, Gaiaz Nugmanov, Vadim Nazarov, Konstantin Khodosevich, Ilgar Mamedov, ...
BioMed Central
... 1945). 17 G. S. Zhdanov and Z. V. Minervina, C. R. Acad. Sci. URSS 48, 43 (1945); ... 1947). 46 G. S. Zhdanov and Z. V. Minervina, J. Phys. (USSR) 9, 244 (1945). 47 F. ...
Tópico(s): Solidification and crystal growth phenomena
1966 - Wiley | physica status solidi (b)
Wuji Zhang, Łukasz Kedzierski, Brendon Y. Chua, Mark Mayo, Claire Lonzi, Vanessa Rigas, Bianca F. Middleton, Hayley A. McQuilten, Louise C. Rowntree, Lilith F. Allen, Ruth A Purcell, Hyon‐Xhi Tan, Jan Petersen, Priyanka Chaurasia, Francesca L. Mordant, Mikhail V. Pogorelyy, Anastasia A. Minervina, Jeremy Chase Crawford, Griffith B. Perkins, Eva Zhang, Stéphanie Gras, E. Bridie Clemens, Jennifer A. Juno, Jennifer Audsley, David S. Khoury, Natasha E. Holmes, Irani Thevarajan, Kanta Subbarao, Florian Krammer, Allen C. Cheng, Miles P. Davenport, Branka Grubor‐Bauk, P Coates, Britt Christensen, Paul G. Thomas, Adam K. Wheatley, Stephen J. Kent, Jamie Rossjohn, Amy W. Chung, John Boffa, Adrian Miller, Sarah Lynar, Jane Nelson, Thi H. O. Nguyen, Jane Davies, Katherine Kedzierska,
High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we found that Australian First Nations peoples elicit effective immune responses to COVID-19 BNT162b2 vaccination, including neutralizing antibodies, receptor-binding domain (RBD) antibodies, SARS-CoV-2 spike-specific B cells, and CD4+ and CD8+ T cells. In First Nations participants, RBD IgG antibody titers were correlated with body mass index and negatively correlated with age. Reduced RBD antibodies, spike-specific ...
Tópico(s): Animal Virus Infections Studies
2023 - Nature Portfolio | Nature Immunology
Carolien E. van de Sandt, Thi H. O. Nguyen, Nicholas A. Gherardin, Jeremy Chase Crawford, Jerome Samir, Anastasia A. Minervina, Mikhail V. Pogorelyy, Simone Rizzetto, Christopher Szeto, Jasveen Kaur, Nicole Ranson, Sabrina Sonda, A. M. Harper, Samuel J. Redmond, Hayley A. McQuilten, Tejas Menon, Sneha Sant, Xiaoxiao Jia, Kate Pedrina, Theo Karapanagiotidis, Natalie Cain, Suellen Nicholson, Zhenjun Chen, Ratana Lim, E. Bridie Clemens, Auda A. Eltahla, Nicole L. La Gruta, Jane Crowe, Martha Lappas, Jamie Rossjohn, Dale I. Godfrey, Paul G. Thomas, Stéphanie Gras, Katie L. Flanagan, Fabio Luciani, Katherine Kedzierska,
Abstract CD8 + T cells provide robust antiviral immunity, but how epitope-specific T cells evolve across the human lifespan is unclear. Here we defined CD8 + T cell immunity directed at the prominent influenza epitope HLA-A*02:01-M1 58–66 (A2/M1 58 ) across four age groups at phenotypic, transcriptomic, clonal and functional levels. We identify a linear differentiation trajectory from newborns to children then adults, followed by divergence and a clonal reset in older adults. Gene profiles in older adults ...
Tópico(s): Immunotherapy and Immune Responses
2023 - Nature Portfolio | Nature Immunology
Thi H. O. Nguyen, Louise C. Rowntree, Lilith F. Allen, Brendon Y. Chua, Łukasz Kedzierski, Chhay Lim, Masa Lasica, Gayani S Tennakoon, Natalie R. Saunders, Megan Crane, Lynette Chee, John F. Seymour, Mary Ann Anderson, Ashley Whitechurch, E. Bridie Clemens, Wuji Zhang, So Young Chang, Jennifer R. Habel, Xiaoxiao Jia, Hayley A. McQuilten, Anastasia A. Minervina, Mikhail V. Pogorelyy, Priyanka Chaurasia, Jan Petersen, Tejas Menon, Luca Hensen, Jessica A. Neil, Francesca L. Mordant, Hyon‐Xhi Tan, Aira F. Cabug, Adam K. Wheatley, Stephen J. Kent, Kanta Subbarao, Theo Karapanagiotidis, Han Huang, Lynn K. Vo, Natalie Cain, Suellen Nicholson, Florian Krammer, Grace Gibney, Fiona James, Janine M. Trevillyan, Jason A. Trubiano, Jeni Mitchell, Britt Christensen, Katherine Bond, Deborah A. Williamson, Jamie Rossjohn, Jeremy Chase Crawford, Paul G. Thomas, Karin Thursky, Monica A. Slavin, Constantine S. Tam, Benjamin W. Teh, Katherine Kedzierska,
Immunocompromised hematology patients are vulnerable to severe COVID-19 and respond poorly to vaccination. Relative deficits in immunity are, however, unclear, especially after 3 vaccine doses. We evaluated immune responses in hematology patients across three COVID-19 vaccination doses. Seropositivity was low after a first dose of BNT162b2 and ChAdOx1 (∼26%), increased to 59%-75% after a second dose, and increased to 85% after a third dose. While prototypical antibody-secreting cells (ASCs) and T follicular ...
Tópico(s): Immunotherapy and Immune Responses
2023 - Elsevier BV | Cell Reports Medicine
Produção Nacional
Revisado por pares
Osires de Medeiros Melo Neto, Lêda Christiane de Figueirêdo Lopes Lucena, Ingridy Minervina Silva, Luciana de Figueirêdo Lopes Lucena, Ana Maria Gonçalves Duarte Mendonça, Albaniza Maria da Silva Lopes, Flavia Maria Mendes da Silva, Alex Guedes de Amorim, Hugo Ribeiro de Oliveira Neto,
Tópico(s): Transport Systems and Technology
2023 - Springer Science+Business Media | Environmental Science and Pollution Research
Mikhail Goncharov, Dmitry Bagaev, Dmitrii S. Shcherbinin, Ivan V. Zvyagin, Dmitriy A. Bolotin, Paul G. Thomas, Anastasia A. Minervina, Mikhail V. Pogorelyy, Kristin Ladell, James E. McLaren, David A. Price, Thi H. O. Nguyen, Louise C. Rowntree, E. Bridie Clemens, Katherine Kedzierska, Garry Dolton, Cristina Rius, Andrew K. Sewell, Jerome Samir, Fabio Luciani, Ksenia V. Zornikova, Alexandra Khmelevskaya, Saveliy A. Sheetikov, Grigory A. Efimov, Dmitriy M. Chudakov, Mikhail Shugay,
Tópico(s): COVID-19 Clinical Research Studies
2022 - Nature Portfolio | Nature Methods
Produção Nacional
Revisado por pares
Ana Maria Gonçalves Duarte Mendonça, Osires de Medeiros Melo Neto, John Kennedy Guedes Rodrigues, Robson Kel Batista de Lima, Ingridy Minervina Silva, Agílio Tomaz Marques,
Lignin is a natural polymer that has antioxidant properties. However, a supplied lignin's physical, chemical, and rheological behaviour will differ from the source. Thus, the objective of this work was to investigate the mechanical performance of asphalt mixtures produced with asphalt binders modified by lignins at the contents of 0, 3, 6, and 9%, from pinus and eucalyptus sawdust. The mixtures were evaluated by performing the Splitting Tensile Strength Test, Lottman, Resilient Modulus, and Dynamic ...
Tópico(s): Lignin and Wood Chemistry
2022 - Taylor & Francis | Australian Journal of Civil Engineering
Anastasia A. Minervina, Mikhail V. Pogorelyy, Allison M. Kirk, Jeremy Chase Crawford, E. Kaitlynn Allen, Ching‐Heng Chou, Robert C. Mettelman, Kim Allison, Chun-Yang Lin, David C. Brice, Zhu Xun, Kasi Vegesana, Gang Wu, Sanchit Trivedi, Pratibha Kottapalli, Daniel Darnell, Suzanne McNeely, Scott R. Olsen, Stacey Schultz‐Cherry, Jeremie H. Estepp, Aditya H. Gaur, James E. Hoffman, Motomi Mori, Li Tang, Elaine Tuomanen, Richard J. Webby, Hana Hakim, Randall T. Hayden, Diego R. Hijano, Resha Bajracharya, Walid H. Awad, Lee-Ann Van de Velde, Brandi L. Clark, Taylor L. Wilson, Aisha Souquette, Ashley Castellaw, Ronald H. Dallas, Jason Hodges, Ashleigh Gowen, Jamie Russell-Bell, James Sparks, David E. Wittman, Thomas Fabrizio, Sean Cherry, Ericka Kirkpatrick Roubidoux, Valerie Cortez, Pamela Freiden, Nicholas Wohlgemuth, Kendall Whitt, Maureen A. McGargill, Joshua Wolf, Paul G. Thomas,
Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high, variant emergence has prompted booster immunizations. However, the effects of repeated exposures to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens on memory T cells are poorly understood. Here, we utilize major histocompatibility complex multimers with single-cell RNA sequencing to profile SARS-CoV-2-responsive T cells ex vivo from humans with one, two or three antigen exposures, including ...
Tópico(s): COVID-19 epidemiological studies
2022 - Nature Portfolio | Nature Immunology
Taylor L. Wilson, Hyunjin Kim, Ching‐Heng Chou, Deanna Langfitt, Robert C. Mettelman, Anastasia A. Minervina, E. Kaitlynn Allen, Jean‐Yves Métais, Mikhail V. Pogorelyy, Janice M. Riberdy, Mireya Paulina Velasquez, Pratibha Kottapalli, Sanchit Trivedi, Scott R. Olsen, Timothy Lockey, Catherine Willis, Michael M. Meagher, Brandon M. Triplett, Aimee C. Talleur, Stephen Gottschalk, Jeremy Chase Crawford, Paul G. Thomas,
Current chimeric antigen receptor-modified (CAR) T-cell products are evaluated in bulk, without assessing functional heterogeneity. We therefore generated a comprehensive single-cell gene expression and T-cell receptor (TCR) sequencing data set using pre- and postinfusion CD19-CAR T cells from blood and bone marrow samples of pediatric patients with B-cell acute lymphoblastic leukemia. We identified cytotoxic postinfusion cells with identical TCRs to a subset of preinfusion CAR T cells. These effector ...
Tópico(s): Silicon Carbide Semiconductor Technologies
2022 - American Association for Cancer Research | Cancer Discovery
Mikhail V. Pogorelyy, Elisa Rosati, Anastasia A. Minervina, Robert C. Mettelman, Alexander Scheffold, André Franke, Petra Bächer, Paul G. Thomas,
The current strategy to detect immunodominant T cell responses focuses on the antigen, employing large peptide pools to screen for functional cell activation. However, these approaches are labor and sample intensive and scale poorly with increasing size of the pathogen peptidome. T cell receptors (TCRs) recognizing the same epitope frequently have highly similar sequences, and thus, the presence of large sequence similarity clusters in the TCR repertoire likely identify the most public and immunodominant ...
Tópico(s): CAR-T cell therapy research
2022 - Elsevier BV | Cell Reports Medicine
Elisa Rosati, Gabriela Rios Martini, Mikhail V. Pogorelyy, Anastasia A. Minervina, Frauke Degenhardt, Mareike Wendorff, Soner Sarı, Gabriele Mayr, Antonella Fazio, C. Marie Dowds, Charlotte A. E. Hauser, Florian Tran, Witigo von Schönfels, Julius Pochhammer, Maria A. Salnikova, Charlot Jaeckel, Johannes Boy Gigla, Sanaz Sedghpour Sabet, Matthias Hübenthal, Esther Schiminsky, Stefan Schreiber, Philip Rosenstiel, Alexander Scheffold, Paul G. Thomas, Wolfgang Lieb, Bernd Bokemeyer, Maria Witte, Konrad Aden, Alexander Hendricks, Clemens Schafmayer, Jan-Hendrick Egberts, Ilgar Z. Mamedov, Petra Bächer, André Franke,
Objective One of the current hypotheses to explain the proinflammatory immune response in IBD is a dysregulated T cell reaction to yet unknown intestinal antigens. As such, it may be possible to identify disease-associated T cell clonotypes by analysing the peripheral and intestinal T-cell receptor (TCR) repertoire of patients with IBD and controls. Design We performed bulk TCR repertoire profiling of both the TCR alpha and beta chains using high-throughput sequencing in peripheral blood samples ...
Tópico(s): IL-33, ST2, and ILC Pathways
2022 - BMJ | Gut
Ekaterina A. Komech, Anastasia Koltakova, Anna Alexandrovna Barinova, Anastasia A. Minervina, Maria A. Salnikova, Е. Шмидт, Т. В. Коротаева, Е. Yu. Loginova, Ш. Ф. Эрдес, Е. А. Богданова, Mikhail Shugay, Sergey A. Lukyanov, Yuri B. Lebedev, Ivan V. Zvyagin,
Spondyloarthritis (SpA) comprises a number of inflammatory rheumatic diseases with overlapping clinical manifestations. Strong association with several HLA-I alleles and T cell infiltration into an inflamed joint suggest involvement of T cells in SpA pathogenesis. In this study, we performed high-throughput T cell repertoire profiling of synovial fluid (SF) and peripheral blood (PB) samples collected from a large cohort of SpA patients. We showed that synovial fluid is enriched with expanded T cell ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2022 - Frontiers Media | Frontiers in Immunology
Louise C. Rowntree, Thi H. O. Nguyen, Łukasz Kedzierski, Melanie R. Neeland, Jan Petersen, Jeremy Chase Crawford, Lilith F. Allen, E. Bridie Clemens, Brendon Y. Chua, Hayley A. McQuilten, Anastasia A. Minervina, Mikhail V. Pogorelyy, Priyanka Chaurasia, Hyon‐Xhi Tan, Adam K. Wheatley, Xiaoxiao Jia, Fatima Amanat, Florian Krammer, E. Kaitlynn Allen, Sabrina Sonda, Katie L. Flanagan, Jaycee Jumarang, Pia S. Pannaraj, Paul V. Licciardi, Stephen J. Kent, Katherine Bond, Deborah A. Williamson, Jamie Rossjohn, Paul G. Thomas, Shidan Tosif, Nigel W. Crawford, Carolien E. van de Sandt, Katherine Kedzierska,
As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains largely unexplored, we recruited convalescent COVID-19 children and adults to define their circulating memory SARS-CoV-2-specific CD4
Tópico(s): Immune Cell Function and Interaction
2022 - Cell Press | Immunity
Produção Nacional
Osires de Medeiros Melo Neto, Ingridy Minervina Silva, Lêda Christiane de Figueirêdo Lopes Lucena, Luciana de Figueirêdo Lopes Lucena, Ana Maria Gonçalves Duarte Mendonça, Robson Kel Batista de Lima,
Tópico(s): Transport Systems and Technology
2022 - Springer Science+Business Media | Waste and Biomass Valorization
Asya Agulnik, Roman Kizyma, Marta Salek, Marcin W. Włodarski, Mikhail V. Pogorelyy, Aleksandra Oszer, Taisiya Yakimkova, Yuliya Nogovitsyna, Małgorzata Dutkiewicz, Jean‐Hugues Dalle, Uta Dirksen, Angelika Eggert, Ana Fernández‐Teijeiro, Jeanette Greiner, Kathelijne C.J.M. Kraal, Alexandra S. Mueller, Lucie Šrámková, Marco Zecca, Paul H. Wise, Wojciech Młynarski, Meghana Avula, Mykhaylo V Adyrov, Pablo Berlanga, Christopher Andrew Blackwood, Éric Bouffet, Piotr Stefan Czauderna, Linda A de Koning, Nuno Jorge Farinha, Whitney Baer Foster, Dylan Elizabeth Graetz, Sumit Gupta, Wolfgang Holter, Rachael Hough, Khrystyna Kliuchkivska, Alexandra Kolenová, Julia Kołodrubiec, Daniel C. Moreira, Sheena Teresa Mukkada, Iryna Volodymyrivna Mykychak, Anna Raciborska, Zeena S Salman, Andriy Sopilnyak, Sergiy Ihorovych Tyupa, Anna Vinitsky, Natalia Margarete Wobst, Beth Anne Miller, Suheir Subhi Rasul, Carlos Rodríguez‐Galindo, Inna Alanbousi, Sarah Weeks Alexander, Anna Apel, Wioletta Bal, Walentyna Aniela Balwierz, Luisa Basset‐Salom, Daniel Bastardo Blanco, Karolina Jadwiga Bauer, Ildar T. Bayazitov, Nickhill Hitesh Bhakta, Ewa Iwona Bien, Katarzyna Anna Bieniek, Sally Jane Blair, Khrystyna Ihorivna Bodak, Irina Michael Bordeianu, Joao Maria Braganca, Mihaela Silvia Bucurenci, Elżbieta Beata Budny, Andrii Budzyn, Christopher Carl Bumgardner, Raina Nichole Burditt, Victoria Grace Burnside Clapp, Viacheslav Valeriyovych Bykov, Adela Cañete, Monica Carnelli, Elena Cela, Zuzanna Paulina Cepowska, Radosław Chaber, Anna Cherner-Drieux, Mariya Chubata, Heidi M Clough, Jolanta Czernicka - Siwecka, K Czyźewski, Olha Dashchakovska, Bozenna Malgorzata Dembowska-Baginska, Katarzyna Derwich, Rachel Dommett, О.І. Дорош, Katarzyna Anna Drabko, Monica Dragomir, Michael Dworzak, Sergii Vitaliiovych Dyma, Julian Darocus Earl, Martin English, D. A. Evseev, Becky S Farren, Nataliia Yuriina Fedyk, Severyn Ferneza, Leeanna Elizabeth Fox Irwin, Robert Maciej Gałązkowski, Galyna Ganieva, Vasylyna Andriivna Garanzha, Marina S. Gelman, Jan Krzysztof Godzinski, Anne Françoise Goeres, Rodica Golban, Michael Griksaitis, Michal Andrzej Hampel, Sara Grace Hastings, Delphine Liliane Heenen, Marcela C Hill, Igor Holiuk, Łukasz Hutnik, Ninela Irga‐Jaworska, Oleksandr Istomin, Szymon Janczar, Arman Kacharian, Krzysztof Kałwak, Grażyna Malgorzata Karolczyk, Nataliia Mikolaivna Karpenko, Halyna Oleksandrivna Katsubo, Bernarda Jadwiga Kaznowska, Alex Kentsis, Petra Ketteler, Anita Kienesberger, Roman Kiselev, Zoryana Kizyma, Hryhorii Ivanovych Klymniuk, Yuliia Kostiuk, Tomasz Kowalik, Олена Козлова, Vladyslav Kozubenko, Tetyana Oleksandrivna Kramar, Maryna Krawczuk‐Rybak, Irina Kulemzina, Paulina Kurkowska, A.S. Kuzyk, Ruth Ladenstein, Paweł Łaguna, Álvaro Lassaletta, Kai Lehmberg, Oksana Leontieva, Serhii Liashenko, Loizos G Loizou, Sonia Anna Lucchetta, Matthew William Lupo, Lesya Lysytsia, Oleksandr Lysytsia, Katarzyna Anna Machnik, Jeff A Mainland, Katarzyna Ewa Matczak, Michal Jacek Matysiak, Pierre Mayeur, Anastasia A. Minervina, Volha Mishkova, Agnieszka Joanna Mizia-Malarz, Andrés Morales La Madrid, Lucas Moreno, V Moskvin, Katarzyna Maria Muszyńska-Rosłan, Akoya Janae' Nelson, Tomasz Ociepa, Stefano Oltolini, Nataliia Onipko, A Pappas, Amit Patel, Alina Alina Patrahau, Jennifer L. Pauley, Yehor Mikhailovich Pavlenko, Andrij Oleksandrovych Pavlovych, Jarosław Peregud‐Pogorzelski, Marta Perek‐Polnik, Vanesa Pérez, Antonio Pérez‐Martínez, Yana Pikman, Graziano Pitozzi Pitozzi, Rui Gentil Portugal, Victoria Vita Posternak, Arcangelo Prete, Kathy Pritchard‐Jones, Alessandra Radaelli, Tegan Reeves, Dirk Reinhardt, Andrey V. Reshetnyak, Andrew Jacob Rider, Carmelo Rizzari, Damiano Rizzi, Karen Gabriela Rodriguez Hermosillo, Olena Volodymyrivna Ronenko, Aneta Olga Rostowska, Liudmyla Yaroslavivna Rudko, Firas Mohamed Sakaan, Nadezhda Sakhar, Н Н Савва, Davide Scaccaglia, Elizabeth Hawthorne Schaeffer, Carina Ursula Schneider, Nicole Scobie, Olena Volodymyrivna Semeniuk, Roksoliana Shevchyk, Ana I Shuler, Stanislav Volodymyrovych Shvets, Szymon Pawel Skoczen, William John Smeal, Igor Sokołowski, Anna Alexandra Sonkin, Alla Ivanivna Stepanjuk, Andrea Spota, Jaroslav Štěrba, Jan Styczyński, Olha Svintsova, Andriy V Synyuta, Tomasz Szczepański, Paweł Kukiz Szczucinski, Bartosz Miroslaw Szmyd, María Tasso Cereceda, Alina Teliuk, Iwona Tomanek, Phoebe Topping, Montserrat Torrent, Joanna Trelińska, Olha Orestivna Troyanovska, Е. В. Трубникова, Lyudmila G Tsurkan, Iryna Tsymbalyuk-Voloshyn, Tomasz Franciszek Urasinski, Agnieszka Urbanek‐Dądela, Nataliia Jroslavivna Vasilieva, Aksana Vasilyeva, Jaime Verdú‐Amorós, Natalia Vilcu-Bajurean, Leo Vinitsky, Giovanni Volpe, Oksana Vorobel, Jacek Tadeusz Wachowiak, Marcin Sławomir Wasiak, Lance Allan Wiedower, Lena Isolde Wuenschel, Mariusz Stanislaw Wysocki, Marina Yurieva, Anastasiia Zagurska, Stanislav S. Zakharenko, Aelita V Zakharenko, Khrystyna Zapotochna, Joanna Emilia Zawitkowska,
On Feb 24, 2022, Russian military forces began a coordinated invasion of Ukraine. Russian assaults resulted in widespread damage to densely populated residential areas and critical civilian infrastructure, including power stations, transportation hubs, schools, and health care facilities. As a result, more than 10 million refugees have fled Ukraine, approximately 50% fleeing to Poland. Attacks on Ukraine's health system and pharmaceutical supply chains created challenges for the provision of critical ...
Tópico(s): Migration, Health and Trauma
2022 - Elsevier BV | The Lancet Haematology
Produção Nacional
Revisado por pares
Osires de Medeiros Melo Neto, Ingridy Minervina Silva, Lêda Christiane de Figueirêdo Lopes Lucena, Luciana de Figueirêdo Lopes Lucena, Ana Maria Gonçalves Duarte Mendonça, Robson Kel Batista de Lima,
The growing demand for advantages and energy and the increase in the economy justify the reduction of the circular environmental impact, which seeks to reduce the circular environmental impact. The use of recycled asphalt pavement (Reclaimed Asphalt Pavement – RAP) in the production of hot asphalt mixes (Hot Asphalt Mixtures – HMA) has been used in paving due to virgin materials. However, the use of high percentages to its RAP damage is susceptible to failure at low temperatures due to fatigue. The addition ...
Tópico(s): Transport Systems and Technology
2022 - Elsevier BV | Construction and Building Materials
Anastasia A. Minervina, Ekaterina A. Komech, Aleksei Titov, Meriem Bensouda Koraichi, Elisa Rosati, Ilgar Z. Mamedov, André Franke, Grigory A. Efimov, Dmitriy M. Chudakov, Thierry Mora, Aleksandra M. Walczak, Yuri B. Lebedev, Mikhail V. Pogorelyy,
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key role in the adaptive antiviral immune response by killing infected cells and facilitating the selection of virus-specific antibodies. However, neither the dynamics and cross-reactivity of the SARS-CoV-2-specific T-cell response nor the diversity of resulting immune memory is well understood. In this study, we use longitudinal high-throughput T-cell receptor (TCR) sequencing to track changes in the T-cell repertoire ...
Tópico(s): Long-Term Effects of COVID-19
2021 - eLife Sciences Publications Ltd | eLife
Philip A. Mudd, Anastasia A. Minervina, Mikhail V. Pogorelyy, Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Jan Petersen, Aaron J. Schmitz, Tingting Lei, Alem Haile, Allison M. Kirk, Robert C. Mettelman, Jeremy Chase Crawford, Thi H. O. Nguyen, Louise C. Rowntree, Elisa Rosati, Katherine A. Richards, Andrea J. Sant, Michael K. Klebert, Teresa Suessen, William D. Middleton, Joshua Wolf, Sharlene A. Teefey, Jane A. O’Halloran, Rachel M. Presti, Katherine Kedzierska, Jamie Rossjohn, Paul G. Thomas, Ali H. Ellebedy, Jeremie H. Estepp, Stacey Schultz‐Cherry, Maureen A. McGargill, Aditya H. Gaur, James E. Hoffman, Motomi Mori, Li Tang, Elaine Tuomanen, Richard J. Webby, Randall T. Hayden, Hana Hakim, Diego R. Hijano, Kim Allison, E. Kaitlynn Allen, Resha Bajracharya, Walid H. Awad, Lee-Ann Van de Velde, Brandi L. Clark, Taylor L. Wilson, Aisha Souquette, Ashley Castellaw, Ronald H. Dallas, Ashleigh Gowen, Thomas Fabrizio, Chun-Yang Lin, David C. Brice, Sean Cherry, Ericka Kirkpatrick Roubidoux, Valerie Cortez, Pamela Freiden, Nicholas Wohlgemuth, Kendall Whitt,
Tópico(s): Immunotherapy and Immune Responses
2021 - Cell Press | Cell
Anastasia A. Minervina, Mikhail V. Pogorelyy, Ekaterina A. Komech, В. К. Карнаухов, Petra Bächer, Elisa Rosati, André Franke, Dmitriy M. Chudakov, Ilgar Z. Mamedov, Yuri B. Lebedev, Thierry Mora, Aleksandra M. Walczak,
The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections. Using TCR alpha and beta repertoire sequencing for T-cell subsets, as well as single-cell RNAseq and TCRseq, we track the concentrations and phenotypes of individual T-cell clones in response to primary and secondary yellow fever immunization — the model for acute infection in humans — showing their large diversity. We confirm the secondary response is an order of magnitude weaker, albeit ∼ ...
Tópico(s): Immunotherapy and Immune Responses
2020 - eLife Sciences Publications Ltd | eLife
Produção Nacional
Revisado por pares
Lucas Loram Lourenço, Fernanda dos Santos Farnese, Leticia F. Sousa, Rauander Douglas Ferreira Barros Alves, Maria Clara Pereira de Andrade, Sabrina Emanuella da Silva Almeida, Luciana Minervina de Freitas Moura, Alan Carlos Costa, Fabiano Guimarães Silva, Jeroni Galmés, Hervé Cochard, Augusto C. Franco, Paulo Eduardo Menezes‐Silva,
Bark is a structure involved in multiple physiological functions, but which has been traditionally associated with protection against fire. Thus, little is known about how the morpho-anatomical variations of this structure are related to different ecological pressures strategies, especially in tropical savanna species, which are commonly subjected to frequent fire and drought events. Here we evaluated how the structural and functional variations of bark are related to the processes of resilience ...
Tópico(s): Tree Root and Stability Studies
2020 - Frontiers Media | Frontiers in Plant Science
Produção Nacional
Revisado por pares
Gabriel Martins Almeida, Adinan Alves da Silva, Priscila Ferreira Batista, Luciana Minervina de Freitas Moura, Roberto Gomes Vital, Alan Carlos Costa,
ABSTRACT Drought is the most harmful environmental factor crop productivity. Some chemicals are used in agriculture to mitigate the damage from this stress on plants. Therefore, we examined whether the spraying of zinc sulfate (ZS), potassium phosphite (KPhi) and the hydrogen sulfide (H2S) donor sodium hydrosulfide (NaHS) would mitigate the deleterious effects of water deficit on sunflower plants by analyzing physiological and biometric characteristics. The experiment was carried out in a greenhouse ...
Tópico(s): Growth and nutrition in plants
2020 - UNIVERSIDADE FEDERAL DE LAVRAS | Ciência e Agrotecnologia
Anastasia A. Minervina, Mikhail V. Pogorelyy, Ilgar Z. Mamedov,
B-cell receptors and T-cell receptors are the key molecules responsible for specific antigen recognition in adaptive immunity. The huge diversity of immune receptor repertoires constrained their comprehensive studies in the past. More recently, however, high-throughput sequencing based techniques have revolutionized the field of immune receptor repertoire profiling enabling new insights into the development and function of the adaptive immune system. In this review we describe current methods for ...
Tópico(s): Immunotherapy and Immune Responses
2019 - Springer Science+Business Media | Transplant International
Mikhail V. Pogorelyy, Anastasia A. Minervina, Mikhail Shugay, Dmitriy M. Chudakov, Yuri B. Lebedev, Thierry Mora, Aleksandra M. Walczak,
Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant information from large high-throughput sequencing of TCR repertoires (RepSeq) data is limited, because little is known about TCR–disease associations. We present Antigen-specific Lymphocyte Identification by Clustering of Expanded sequences (ALICE), a statistical approach that identifies TCR sequences actively involved in current ...
Tópico(s): T-cell and B-cell Immunology
2019 - Public Library of Science | PLoS Biology
Mikhail V. Pogorelyy, Anastasia A. Minervina, Dmitriy M. Chudakov, Ilgar Z. Mamedov, Yuri B. Lebedev, Thierry Mora, Aleksandra M. Walczak,
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated ...
Tópico(s): T-cell and B-cell Immunology
2018 - eLife Sciences Publications Ltd | eLife
Produção Nacional
Revisado por pares
Leidiane Minervina Moraes de Sabino, Ádria Marcela Vieira Ferreira, Emanuella Silva Joventino, Francisca Elisângela Teixeira Lima, Jardeliny Corrêa da Penha, Kamila Ferreira Lima, Ludmila Alves do Nascimento, Lorena Barbosa Ximenes,
Resumo Objetivo Elaborar, validar e avaliar uma cartilha educativa para a promoção da autoeficácia materna na prevenção da diarreia infantil. Método Estudo metodológico, desenvolvido a partir da elaboração, validação e avaliação do material educativo por 30 juízes de conteúdo e três técnicos. Para validação, avaliou-se clareza da linguagem, pertinência prática e relevância teórica, calculando-se o Índice de Validade de Conteúdo para cada item; e aplicou-se o instrumento Suitability Assesment of ...
Tópico(s): Infant Development and Preterm Care
2018 - UNIVERSIDADE FEDERAL DE SÃO PAULO | Acta Paulista de Enfermagem
Mikhail V. Pogorelyy, Anastasia A. Minervina, Maximilian Puelma Touzel, Anastasiia L. Sycheva, Ekaterina A. Komech, Elena I. Kovalenko, Galina G. Karganova, Evgeniy S. Egorov, Alexander Komkov, Dmitriy M. Chudakov, Ilgar Z. Mamedov, Thierry Mora, Aleksandra M. Walczak, Yuri B. Lebedev,
T cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remains a major challenge. Here we developed a statistical framework to detect TCR clone proliferation and contraction from longitudinal repertoire data. We applied this framework to data from three pairs of identical twins immunized with the yellow fever vaccine. We identified 600 to 1,700 responding TCRs in each donor and validated ...
Tópico(s): Immunotherapy and Immune Responses
2018 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Produção Nacional
Revisado por pares
Tatiana Takahasi Komoto, Tayná Minervina Bernardes, Thaís Balthazar Mesquita, Luis Felipe Buso Bortolotto, Gabriel Silva, Tamires A. Bitencourt, Seung Joon Baek, Mozart Marins, Ana Lúcia Fachin,
In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licochalcone ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2018 - Multidisciplinary Digital Publishing Institute | Molecules
Produção Nacional
Revisado por pares
Leidiane Minervina Moraes de Sabino, Ádria Marcela Vieira Ferreira, Elizamar Regina da Rocha Mendes, Emanuella Silva Joventino, Fabiane do Amaral Gubert, Jardeliny Corrêa da Penha, Kamila Ferreira Lima, Ludmila Alves do Nascimento, Lorena Barbosa Ximenes,
to validate an educational primer, regarding content and design, for promoting maternal self-efficacy in preventing childhood diarrhea.methodological study composed of 31 mothers of children under five years of age, in which the validation of the primer You can prevent diarrhea in your child! was carried out from the Content Validity Index (CVI), being evaluated as to the domains understanding, attractiveness, self-efficacy, cultural acceptance, and persuasion.the primer was considered relevant and ...
Tópico(s): Nursing Diagnosis and Documentation
2018 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem
Anastasiia L. Sycheva, Mikhail V. Pogorelyy, Ekaterina A. Komech, Anastasia A. Minervina, Ivan V. Zvyagin, Dmitriy B. Staroverov, Dmitriy M. Chudakov, Yuri B. Lebedev, Ilgar Z. Mamedov,
Vaccination against influenza is widely used to protect against seasonal flu epidemic although its effectiveness is debated. Here we performed deep quantitative T cell receptor repertoire profiling in peripheral blood of a healthy volunteer in response to trivalent subunit influenza vaccine. We did not observe significant rebuilding of peripheral blood T cell receptors composition in response to vaccination. However, we found several clonotypes in memory T cell fraction that were undetectable before ...
Tópico(s): T-cell and B-cell Immunology
2018 - Elsevier BV | Vaccine