Yasuo Sugita, Mizuhiko Terasaki, Daisuke Niino, Koichi Ohshima, Fumiko Arakawa, Minoru Shigemori, Yasuharu Sato, Naoko Asano,
Tópico(s): Viral-associated cancers and disorders
2010 - Springer Science+Business Media | Journal of Neuro-Oncology
Hiroaki Kurishita, S. Matsuo, H. Arakawa, Minoru Narui, Masanori Yamazaki, Tatsuaki Sakamoto, S. Kobayashi, Kenta Nakai, Tomohiro Takida, Katsushi Takebe, Masayoshi Kawai, Norihiro Yoshida,
Ultra-fine grained (UFG) W-TiC consolidates are very promising for use as divertors in fusion reactors, however, the assurance of room-temperature ductility of UFG W-TiC remains unsettled. The assurance requires a sufficient degree of plastic working for the consolidates and thus overcoming of poor plastic workability in UFG W-TiC by applying superplasticity. Therefore, the magnitudes of elongation to fracture and flow stress which are important measures for plastic working were examined for UFG ...
Tópico(s): Advanced materials and composites
2008 - Elsevier BV | Journal of Nuclear Materials
Taishin Takuma, Toshiya Arakawa, Minoru Okayama, Itaru Mizoguchi, Akihiko Tanimura, Yoshifumi Tajima,
SNARE proteins are widely accepted to be involved in the docking and fusion process of intracellular vesicle trafficking. VAMP-2, syntaxin-4, and SNAP-23 are plausible candidate SNARE proteins for non-neuronal exocytosis. Thus, we examined the localization, protein-protein interaction, and intracellular trafficking of these proteins by expressing them as green fluorescent protein (GFP)- and FLAG-tagged fusion proteins in various cells, including HSY cells, a human parotid epithelial cell line. GFP- ...
Tópico(s): Microtubule and mitosis dynamics
2002 - Oxford University Press | The Journal of Biochemistry
Sitiro MINAGAWA, Ken-ichi ARAKAWA, Minoru Yamada,
The authors start with an analytical study on the propagation of plane harmonic waves in an infinitely extended, cubi-anisotropic, elastic, and micropolar medium. It is possible to have six fundamental waves. Of these, a longitudinal uncoupled displacement wave and two coupled transverse waves of displacement and microrotation which become uncoupled with become uncoupled displacement waves at the limit of long wavelength are compared with the acoustical waves in the classical theory. The micropolar ...
Tópico(s): Geophysics and Sensor Technology
1981 - Japan Society Mechanical Engineers | Bulletin of JSME
Yusuke Toyota, Yoko Matsuura, Masashi Ito, Ryota Domura, Masami Okamoto, Shuichi Arakawa, Minoru Hirano, Katsunori Kohda,
Clay minerals are mainly used around traditional cosmetics and industrial products, but currently their target application is continuously expanding into pharmaceutical industry and tissue engineering. To broaden the knowledge of in vitro cytotoxicity of allophane nanoparticles against human cancer cells, the cytotoxicity of both natural and synthetic allophane nanoparticles for cultured human alveolar basal epithelial (A549) cells was examined. For both natural and synthetic allophones, the A549 ...
Tópico(s): Bone Tissue Engineering Materials
2016 - Elsevier BV | Applied Clay Science
Tsutomu Arakawa, Minoru Yoshida, Hideaki Morishita, Junko Honda, Daizo Yonezawa,
It was found in the previous studies that the quality of flour is closely related to the aggregation behavior of gluten separated from it, and that difference of aggregation behavior of gluten was mainly due to the nature of glutenin contained in it. In the present paper, aggregation behaviors of glutenins were investigated in relation to their polypeptide compositions with ten kinds of flours. Component polypeptides of glutenin were fractionated into three fractions, FI, FII and FIII, by gel filtration, ...
Tópico(s): Microbial Metabolites in Food Biotechnology
1977 - Oxford University Press | Agricultural and Biological Chemistry
Toshihiko Iuchi, Akihiro Inoue, Yuichi Hirose, Motohiro Morioka, Keishi Horiguchi, Atsushi Natsume, Yoshiki Arakawa, Koichi Iwasaki, Minoru Fujiki, Toshihiro Kumabe, Yukinori Sakata,
Abstract Background Adjuvant treatment with Gliadel wafers may prolong overall survival (OS) for malignant glioma patients without increasing toxicity. In Japan, the long-term OS of these patients treated with Gliadel 7.7 mg implants has not been studied. We evaluated OS and prognostic factors that might affect OS in Japanese patients with malignant glioma who received the Gliadel 7.7 mg implant. Methods This observational, long-term, postmarketing surveillance was an extension of a previous surveillance. ...
Tópico(s): Brain Metastases and Treatment
2022 - Oxford University Press | Neuro-Oncology Advances
Kenjiro Matsumoto, Tomoharu Nakajima, Hiroyasu Sakai, S. Kato, Atsunobu Sagara, Kazuhiko Arakawa, Kimihito Tashima, Minoru Narita, Syunji Horie,
Tópico(s): Cancer therapeutics and mechanisms
2013 - Springer Science+Business Media | Digestive Diseases and Sciences
Motohiro Esaki, Takayuki Matsumoto, Kenji Watanabe, Tetsuo Arakawa, Yuji Naito, Minoru Matsuura, Hiroshi Nakase, Toshifumi Hibi∥, Takayuki Matsumoto, Sadaharu Nouda, Kazuhide Higuchi, Naoki Ohmiya, Hidemi Goto, Sei Kurokawa, Satoshi Motoya, Mamoru Watanabe,
Abstract Background and Aim Until the approval of patency capsule, capsule endoscopy ( CE ) has not been routinely applied for the diagnosis of C rohn's disease ( CD ) in J apan. We aimed to survey current situation of CE use for patients with CD in J apan. Methods The nationwide survey of 40 J apanese institutions identified 94 patients with established CD (e CD ) and 80 patients with suspected CD (s CD ), who were examined by CE . Types and positive rates of mucosal injury under CE and capsule retention rate were ...
Tópico(s): Gastrointestinal disorders and treatments
2013 - Wiley | Journal of Gastroenterology and Hepatology
S. Minagawa, Kazuto Arakawa, Minoru Yamada,
The elastic constants of diamond and its local moment of inertia are estimated. The diamond crystal is assumed as a Cosserat continuum with constrained rotation. After a brief survey on the dispersion relations for waves in the continuum, the micropolar material constants are evaluated from the experimental data on the lattice vibrations in diamond. Numerical results are presented. Les auteurs calculent les constantes élastiques, et le coefficient d'inertie locale, pour cristaux de diamant. Le cristal ...
Tópico(s): Mechanical and Optical Resonators
1980 - Wiley | physica status solidi (a)
Kazuto Arakawa, Takafumi Amino, Minoru Isshiki, Kouji Mimura, Masahito Uchikoshi, Hirotaro Mori,
One-dimensional (1D) glide diffusion of interstitial-type prismatic dislocation loops is believed to play key roles in microstructural evolutions within nuclear-fusion and fission materials upon energetic particle irradiation. In the present study, using in-situ transmission electron microscopy, we have examined behaviors of nanoscale 1/2 loops in high-purity α-iron at "low temperatures" ranging from 15 to 290 K, under zero external stress. We observed 1D intermittent and fast motion of loops above ...
Tópico(s): Microstructure and mechanical properties
2014 - The Iron and Steel Institute of Japan | ISIJ International
Atsunobu Sagara, Katsuhide Igarashi, Maky Otsuka, Akihiro Kodama, Mutsumi Yamashita, Rei Sugiura, Takeshi Karasawa, Kazuhiko Arakawa, Michiko Narita, Naoko Kuzumaki, Minoru Narita, Yoshinori Katō,
Triple-negative breast cancer (TNBC) has aggressive characteristics and fewer treatment options than other subtypes. The purpose of this study was to explore prognostic biomarkers for TNBC that can be easily detected from the blood samples. MDA-MB-231 and MDA-MB-231BR, a brain metastatic variant of the human TNBC cell line MDA-MB-231, were used as less and more aggressive models of TNBC, respectively. The extent to which the candidate gene/protein identified by RNA sequencing correlated well with ...
Tópico(s): Inflammation biomarkers and pathways
2016 - Springer Science+Business Media | Breast Cancer Research and Treatment
Thomas D. Swinburne, Kazuto Arakawa, Hirotaro Mori, Hidehiro Yasuda, Minoru Isshiki, Kouji Mimura, Masahito Uchikoshi, S. L. Dudarev,
Abstract Vacancy-mediated climb models cannot account for the fast, direct coalescence of dislocation loops seen experimentally. An alternative mechanism, self climb, allows prismatic dislocation loops to move away from their glide surface via pipe diffusion around the loop perimeter, independent of any vacancy atmosphere. Despite the known importance of self climb, theoretical models require a typically unknown activation energy, hindering implementation in materials modeling. Here, extensive molecular ...
Tópico(s): Microstructure and mechanical properties
2016 - Nature Portfolio | Scientific Reports
Mizuhiko Terasaki, Yasuo Sugita, Fumiko Arakawa, Yosuke Okada, Koichi Ohshima, Minoru Shigemori,
Tópico(s): interferon and immune responses
2011 - Springer Science+Business Media | Brain Tumor Pathology
Yasushi Sasajima, Takushi Arakawa, Minoru Ichimura, Mamoru Imabayashi,
The dynamics of ultra-fine particles (UFP's) have been studied by the molecular dynamics method. The Morse-type function has been assumed as the interaction potential between the atoms in UFP's. The numbers of atoms of the calculated systems have been 13 to 459. The particles with magic numbers, 13, 55 and 147, have shown the structural change from fcc to icosahedron, while the system of 459 atoms has not.
Tópico(s): Advanced Chemical Physics Studies
1989 - Institute of Physics | Japanese Journal of Applied Physics
Chikako Shimokawa, Tamotsu Kato, Tadashi Takeuchi, Noriyasu Ohshima, Takao Furuki, Yoshiaki Ohtsu, Kazutomo Suzue, Takashi Imai, Seiji Obi, Alex Olia, Takashi Izumi, Minoru Sakurai, Hirokazu Arakawa, Hiroshi Ohno, Hajime Hisaeda,
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic β-cells are destroyed. Intestinal helminths can cause asymptomatic chronic and immunosuppressive infections and suppress disease in rodent models of T1D. However, the underlying regulatory mechanisms for this protection are unclear. Here, we report that CD8+ regulatory T (Treg) cells prevent the onset of streptozotocin -induced diabetes by a rodent intestinal nematode. Trehalose derived from nematodes affects the intestinal ...
Tópico(s): T-cell and B-cell Immunology
2020 - Nature Portfolio | Nature Communications
Yuji Nadatani, Toshio Watanabe, Tetsuya Tanigawa, Mitsue Sogawa, Hirokazu Yamagami, Masatsugu Shiba, Kenji Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Minoru Yoshiyama, Tetsuo Arakawa,
Low-dose aspirin (LDA) is the most commonly prescribed antiplatelet agent for prevention of cardiovascular events following percutaneous coronary intervention (PCI). Long-term treatment with LDA has serious adverse effects, including gastrointestinal (GI) hemorrhage. Most studies have focused only on upper GI bleeding and few studies have evaluated the effect of LDA on total GI bleeding.The aims of this study were to investigate the incidence and risk factors of total GI bleeding within 30 days after ...
Tópico(s): Heparin-Induced Thrombocytopenia and Thrombosis
2013 - Taylor & Francis | Scandinavian Journal of Gastroenterology
Mizuho Nagao, Kenji Oku, Anzu Minami, K Mizuno, Minoru Sakurai, Kenichiro Arakawa, S. Fujikawa, Daisuke Takezawa,
Mosses are known to have the ability to develop high degrees of resistance to desiccation and freezing stress at cellular levels. However, underlying cellular mechanisms leading to the development of stress resistance in mosses are not understood. We previously showed that freezing tolerance in protonema cells of the moss Physcomitrella patens was rapidly increased by exogenous application of the stress hormone abscisic acid (ABA) [Minami, A., Nagao, M., Arakawa, K., Fujikawa, S., Takezawa, D., 2003a. ...
Tópico(s): Plant nutrient uptake and metabolism
2006 - Elsevier BV | Phytochemistry
Kuniharu Nojima, Helfrid Hochegger, Alihossein Saberi, Toru Fukushima, Koji Kikuchi, Michio Yoshimura, Brian J. Orelli, Douglas K. Bishop, Seiki Hirano, Mioko Ohzeki, Masamichi Ishiai, Kazuhiko Yamamoto, Minoru Takata, Hiroshi Arakawa, Jean-Marie Buerstedde, Mitsuyoshi Yamazoe, Takuo Kawamoto, Kasumi Araki, Jun Takahashi, Nobuo Hashimoto, Shunichi Takeda, Eiichiro Sonoda,
Abstract Cross-linking agents that induce DNA interstrand cross-links (ICL) are widely used in anticancer chemotherapy. Yeast genetic studies show that nucleotide excision repair (NER), Rad6/Rad18-dependent postreplication repair, homologous recombination, and cell cycle checkpoint pathway are involved in ICL repair. To study the contribution of DNA damage response pathways in tolerance to cross-linking agents in vertebrates, we made a panel of gene-disrupted clones from chicken DT40 cells, each defective ...
Tópico(s): Microtubule and mitosis dynamics
2005 - American Association for Cancer Research | Cancer Research
Yasuo Sugita, Minoru Shigemori, Kenichi Okamoto, Minoru Morimatsu, Masaaki Arakawa, Kenji Nakayama,
The correlation between histopathological characteristics and prognosis was studied in six cases of pleomorphic xanthoastrocytomas (PXA) found in five patients. With regard to the duration from onset to the resection of the tumor, and the postoperative course, three cases had a favorable prognosis, although one case fatally recurred and in another, serial CT showed rapid tumor growth for 3 years. The histological characteristics of the favorable group of PXA comprised remarkable degeneration, low ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2000 - Wiley | Pathology International
Satoru Suzuki, K. Sugai, Hirokazu Sato, Minoru Sakatume, Masaaki Arakawa,
The effect of dipyridamole on active oxygen generation by human polymorphonuclear leukocytes (PMN) was investigated. Dipyridamole inhibited the production of oxidative metabolites from human PMN stimulated by opsonized zymosan and formyl-methionyl-leucyl-phenylalanine dose and time dependently. To determine whether dipyridamole directly inhibits the production of oxygen metabolites by human PMN, human PMN were preincubated with dipyridamole washed prior to stimulation. Dipyridamole was found to directly ...
Tópico(s): Hemoglobin structure and function
1992 - Elsevier BV | European Journal of Pharmacology Molecular Pharmacology
Katsumi Shigemura, Tomihiko Yasufuku, Minoru Matsumoto, Yoshihisa Kinoshita, Kunito Yamanaka, Masuo Yamashita, Yuzo Nakano, Kazushi Tanaka, Sochi Arakawa, Masato Fujisawa,
... Yamanaka, Masuo Yamashita, Yuzo Nakano, Kazushi Tanaka, Sochi Arakawa, and Masato Fujisawa Katsumi ShigemuraKatsumi Shigemura Akashi, Japan , Tomihiko YasufukuTomihiko Yasufuku Kobe, Japan , Minoru MatsumotoMinoru Matsumoto Kobe, Japan , Yoshihisa KinoshitaYoshihisa Kinoshita Akashi, Japan , Kunito YamanakaKunito Yamanaka Akashi, Japan , Masuo YamashitaMasuo Yamashita Akashi, Japan , Yuzo NakanoYuzo Nakano Kobe, Japan , Kazushi TanakaKazushi Tanaka Kobe, Japan , Sochi ArakawaSochi Arakawa Kobe, Japan , and Masato FujisawaMasato Fujisawa Kobe, Japan ...
Tópico(s): Genital Health and Disease
2010 - Lippincott Williams & Wilkins | The Journal of Urology
Nobumasa Kato, Sumikazu Ishii, Hiroshi Naruse, Minoru Irie, Hidestoshi Arakawa, Akio Tsuji,
Abstract A method for enzyme imnunoassay of thyroid-stimulating hormone (TSH) in dried blood spotted onto filter paper has been developed. TSH was conjugated to horse-radish peroxidase according to Nakane's method. Separation of the bound and free fractions was obtained by a double antibody solid phase method using polyacetal beads which were coated with the purified IgG fraction from goat anti-rabbit IgG serum. p-Hydroxyphenyl propionic acid was used as substrate for the fluorophotometric assay ...
Tópico(s): Pharmacological Effects and Assays
1980 - Taylor & Francis | Analytical Letters
Yasuhiro Aso, Kenichiro Nakamura, Noriyuki Kimura, Makoto Takemaru, Ryuki Arakawa, Minoru Fujiki, Teruyuki Hirano, Toshihide Kumamoto, Etsuro Matsubara,
<b><i>Background:</i></b> Cerebrovascular white matter lesions (WMLs) are associated with cognitive impairment in patients with subcortical vascular dementia. We performed a comprehensive gene expression analysis to elucidate genes associated with WML development in a chronic cerebral hypoperfusion rat model. <b><i>Methods:</i></b> Brains of rats with bilateral carotid ligation (2VO, n = 10) and sham-operated rats (n = 5-10/group) were removed on days 1, 7, or ...
Tópico(s): Neurological Disorders and Treatments
2016 - Karger Publishers | Pathobiology
Soji Ozawa, Mitsuteru Yoshida, Keiichi Kumai, Kenichi Higuchi, Takeo Arakawa, Minoru Kato, M. Asaka, Natsuya Katada, Hitoshi Shimao, Hiroyuki Kuwano, Michio Kitajima,
Tópico(s): Dysphagia Assessment and Management
2008 - Japan Broncho-esophagological Society | Nihon Kikan Shokudoka Gakkai Kaiho
Tōru Arakawa, Yusuke Kato, Makoto Hattori, Minoru Yamakawa,
Tópico(s): Insect Utilization and Effects
1996 - Elsevier BV | Insect Biochemistry and Molecular Biology
Hiroharu Arakawa, Hiroyoshi Matsumoto, Masashi Morita, Minoru Sasaki, Kazuhiro Taguchi, Akira Okura, Susumu Nishimura,
IMC-HM cells were isolated from spontaneously induced ascitic IMC carcinoma cells that had been maintained intraperitoneally in CDF1 mice. Metastasis to the liver of subcutaneously implanted IMC-HM cells was detected 10 days after implantation into the flanks of mice (day 10), but metastasis to other organs was limited. Thereafter, however, tumor cells spread rapidly to lymph nodes, lung, spleen, ovary and other organs, and the mice died on day 13 to 18. We report here, together with the properties ...
Tópico(s): Cancer Cells and Metastasis
1996 - Oxford University Press | Japanese Journal of Cancer Research
Yuichiro Watanabe, Shinya Honda, Akimitsu Konishi, Satoko Arakawa, Michiko Murohashi, Hirofumi Yamaguchi, Satoru Torii, Minoru Tanabe, Shinji Tanaka, Eiji Warabi, Shigeomi Shimizu,
Abstract Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin–proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63 (Cep63) given that cells lacking autophagy contain multiple Cep63 dots that are engulfed and ...
Tópico(s): Microtubule and mitosis dynamics
2016 - Nature Portfolio | Nature Communications
Hiroyuki Kitao, Indrajit Nanda, Ryuichi P. Sugino, Aiko Kinomura, Mitsuyoshi Yamazoe, Hiroshi Arakawa, Michael Schmid, Hideki Innan, Kevin Hiom, Minoru Takata,
Defects in the FANCJ/BRIP1 helicase gene are associated with genome instability disorders such as familial breast cancer or Fanconi anemia (FA). Although FANCJ has an in vitro activity to resolve G-quadruplex (G4) structures, and FANCJ ortholog in C. elegans prevents G4-associated deletions during replication, how FANCJ loss affects genome integrity in higher organisms remains unclear. Here, we report that FANCJ, but not other FA genes FANCD2 or FANCC, protected against large-scale genomic deletion ...
Tópico(s): Photosynthetic Processes and Mechanisms
2011 - Wiley | Genes to Cells
Tsuneo Arakawa, Masako Fujii, Kazuo Ōhara, Shuichi Watanabe, Minoru Karahashi, Mayumi Kobayashi, Haruko Hirono,
In 1963 a probably new metabolic error of folic acid was reported by us under a term ‘formiminotransferase deficiency syndrome’. It was characterized by mental retardation, hyperfolic acidemia and urinary excretion of large amounts of formiminoglutamic acid (FIGLU) following an oral dose of L-histidine. The primary lesion was demonstrated to be a defective activity of formiminotransferase in liver tissues. The present paper presented another type of metabolic error of folic acid which consisted of ...
Tópico(s): Neonatal Health and Biochemistry
1966 - Tohoku University | The Tohoku Journal of Experimental Medicine