Photograph of Mir Masum's minar at Sukkar in the Shikarpur District of Sindh, Pakistan, taken by Henry Cousens in 1896. ... presumably the structure converted into a resthouse by Mir Masum and at the extreme left is Mir ...
0000 - Gale Group | NCCO Photography
Huan Wang, Yue Zhang, Chengfei Zhang, Yan Zhao, Jun Shu, Tang Xue-zhang,
... synoviocyte (FLS)-derived exosomes (FLS-Exos), influenced by miR-146a, on AC degradation and synovial macrophage polarization. We investigated the targeted relationship between miR-146a and TRAF6, both in vivo and in ... NF-κB signaling pathway. Results The expression of miR-146a in the synovial exosomes of OA rats ... in healthy rats. In vitro , the upregulation of miR-146a reduced chondrocyte apoptosis, whereas its downregulation had the opposite effect. In vivo , exosomes derived from miR-146a-overexpressing FLSs (miR-146a-FLS-Exos) reduced ...
Tópico(s): Osteoarthritis Treatment and Mechanisms
2024 - Frontiers Media | Frontiers in Immunology
Photograph of Mir Masum's Tomb at Sukkar in the Shikarpur District of Sindh, Pakistan, taken by Henry Cousens in 1896. ... shadow of the minar rest the remains of Mir Muhammad Ma'sum Shah, his father, and other ...
0000 - Gale Group | NCCO Photography
Fei Yu, Yue Wang, Caiyuan Yu, Wei Zhang, Xuefeng Bai,
Abstract miR-18a has been identified as a significantly expressed microRNA (miRNA) in non-small cell lung cancer (NSCLC) ... pairs based on single nucleotide polymorphism analyses of miR-18a and miR-18b was first designed and screened to develop ... shaped ratio biosensor for accurate detection of serum miR-18a in NSCLC. The special structure of the ... combined with the hairpin showed strong specificity for miR-18a, which was confirmed by polyacrylamide gel electrophoresis ... detection range and can quantify the concentration of miR-18a in the range of 10 fmol/L– ...
Tópico(s): RNA Interference and Gene Delivery
2024 - Springer Science+Business Media | Journal of Analysis and Testing
Photograph of the Mir Alam Lake, near the city of Hyderabad, Andrea Pradesh, taken by Deen Dayal in the 1880s. This is from ... the Nizam's Dominions, Hyderabad, Deccan, 1892'. The Mir Alam Tank, near Hyderabad, is a fine piece ...
0000 - Gale Group | NCCO Photography
Martina Faraldi, Veronica Sansoni, Jacopo Antonino Vitale, Silvia Perego, Marta Gomarasca, Chiara Verdelli, Carmelo Messina, Luca Maria Sconfienza, Giuseppe Banfi, Sabrina Corbetta, Giovanni Lombardi,
... enzyme‐linked immunosorbent assays. Results Five miRNAs (hsa‐miR‐221‐3p, hsa‐miR‐374b‐5p, hsa‐miR‐146a‐5p, hsa‐miR‐126‐5p and hsa‐miR‐425‐5p) resulted down‐regulated and two miRNAs (hsa‐miR‐145‐5p and hsa‐miR‐25‐3p) were up‐regulated in the first ... 0.8 ( P < 0.05). Two signatures hsa‐miR‐126‐5p, hsa‐miR‐146a‐5p and hsa‐miR‐425‐5p; and hsa‐miR‐126‐5p, hsa‐ ...
Tópico(s): Circular RNAs in diseases
2024 - Springer Science+Business Media | Journal of Cachexia Sarcopenia and Muscle
... of miscellaneous fragments of sculptured brick from Thul-Mir-Rukhan and Depar Gangro in Sind in Pakistan, ... to that found at Mirpur-Khas and Thul Mir Rukhan, and so very like the work at ...
0000 - Gale Group | NCCO Photography
Xueqiong Liu, Zhiyue Li, Dan Lü,
Abstract Objective To investigate the regulatory role of miR-223-3p in the inflammatory response of PE ... collected to measure the expression of NLRP3 and miR-223-3p. The targeting relationship between NLRP3 and miR-223-3P was verified by bioinformatics analysis and ... PE placental cell inflammation model. Then we transfected miR-223-3p overexpression/miR-223-3p negative control plasmid into the LPS- ... were evaluated to elucidate the regulatory effect of miR-223-3p on the inflammatory response mediated by ...
Tópico(s): MicroRNA in disease regulation
2024 - BioMed Central | BMC Pregnancy and Childbirth
Photograph of the Mir Alam Tank, Hyderabad, from the Macnabb Collection (Col James Henry Erskine Reid): Album of Indian views taken in c.1902-03. The Mir Alam Tank was built by French engineers and ...
0000 - Gale Group | NCCO Photography
Kaiyue Zhao, Jianghong Liu, Ting Sun, Li Zeng, Zhongdi Cai, Zhuorong Li, Rui Liu,
... AD. This study identified a novel microRNA termed miR-25802 from our high-throughput sequencing dataset of ... mechanism. The results confirmed the miRNA properties of miR-25802 based on bioinformatics and experimental verification. Expression of miR-25802 was increased in the plasma of AD ... Functional studies suggested that overexpression or inhibition of miR-25802 respectively aggravated or ameliorated AD-related pathology, ... or LPS/IFN-γ-stimulated EOC20 microglia. Mechanistically, miR-25802 negatively regulates KLF4 by directly binding to ...
Tópico(s): Circular RNAs in diseases
2024 - Elsevier BV | Brain Behavior and Immunity
Letters: M. B. Hubbard; December 28, 1877 to Mir Hartford; Madison, Ohio.
1877 - Gale Group | SAS Part 1
Keping Deng, Fang Zou, Jin Xu, Dayong Xu, Zhen Luo,
... were cultured at normoxia/hypoxia. HIF‐1α and miR‐21 expression levels were assessed by RT‐qPCR ... enhanced by hypoxia. Hypoxia induced HIF‐1α and miR‐21 overexpression in CAFs. Hypoxia promoted CAFs to secrete high‐level miR‐21 EVs via the HIF‐1α/miR‐21 axis, and activated the miR‐21/RAS/AKT/ERK pathway. CAF‐EVs promoted GEM resistance in PC via the miR‐21/RAS/ATK/ERK pathway in vivo. Hypoxia promoted CAFs to secrete high‐level miR‐21 EVs through the HIF‐1α/miR‐21 axis, and activated the miR‐21/RAS/ ...
Tópico(s): Cancer Cells and Metastasis
2024 - Wiley | Molecular Carcinogenesis
Photograph of the tope (stupa) at Mir Rukan in Sind, Pakistan, taken by a photographer of the Archaeological survey of India in the 1870s. This Buddhist stupa, or funerary ...
0000 - Gale Group | NCCO Photography
Danlei Wang, Hongling Gao, Qixiong Qin, Jingyi Li, Jingwei Zhao, Yi Qu, Jiangting Li, Yongjie Xiong, Zhe Min, Zhijuan Mao, Zheng Xue,
... factors to the PD pathology. MicroRNA-218-5p (miR-218-5p) is a microRNA that plays a ... remains unclear. Methods We explore the involvement of miR-218-5p in the PD in a 1- ... 3,6-tetrahydropyridine (MPTP)-induced mouse model. The miR-218-5p agomir used for overexpression was delivered ... was performed to explore the pathways regulated by miR-218-5p. The target genes of miR-218-5p were predicted using TargetScan and confirmed using dual luciferase reporter assays. The effects of miR-218-5p on microglial inflammation and related pathways ...
Tópico(s): Nuclear Receptors and Signaling
2024 - BioMed Central | Journal of Translational Medicine
Photograph of a Buddhist sculpture slab from Mir Jan in Peshawar District showing the Buddha taking leave from his wife.This photograph was taken as part of the Archaeological Survey of ...
0000 - Gale Group | NCCO Photography
Md. Ariful Islam, Omme Fatema Sultana, M.D Dr.Sudhakar Bandari, Sudhir Kshirsagar, Pulak R. Manna, P. Hemachandra Reddy,
... our lab revealed that microRNA-455-3 P (miR-455-3p) is a strong candidate as a ... the pathogenesis of AD are directly targeted by miR-455-3p. Several years of our lab research revealed that miR-455-3p regulates important physiological processes associated with ... mitochondrial biogenesis, and synaptic damages. The expression of miR-455-3p in mild cognitive impaired subjects and ... lab generated both transgenic and knockout mice for miR-455-3p. Interestingly miR-455-3p transgenic mice showed superior cognitive learning, ...
Tópico(s): Cancer-related molecular mechanisms research
2024 - Elsevier BV | Ageing Research Reviews
Photograph of a Buddhist sculpture slab from Mir Jan in Peshawar District showing Mara's attack on the Buddha.These fragments shown boxed for transportation are sculpture slabs or urdhvapattas (sculptures ...
0000 - Gale Group | NCCO Photography
Qiaoying Chen, Yina Jiang, Xuan Guan, Fangfang Ren, Shu-jie Wu, Maoping Chu, Lianpin Wu, Tengfang Lai, Lei Li,
... reducing cardiovascular disease mortality and hospitalization rates. MicroRNAs (miRs) are closely related to heart disease, among which miR-574-3p plays an important role in myocardial ... was used to detect the expression levels of miR-574-3p and cardiac hypertrophy markers. Western blotting ... that aerobic exercise upregulated the expression level of miR-574-3p (n=6). After specific knockdown of miR-574-3p in mouse hearts with adeno-associated ... histopathologic staining showed that inhibiting the expression of miR-574-3p could partially block the effects of ...
Tópico(s): Cardiovascular Effects of Exercise
2024 - Lippincott Williams & Wilkins | Circulation Heart Failure
Photograph of Buddhist sculptures from Mir Jan, Peshawar district, taken by Henry Cole in c. 1883 showing the sculptures boxed for transportation. Urdhvapattas are sculptures depicting scenes ...
0000 - Gale Group | NCCO Photography
S.P. SINGH, Sangeeta Saxena, Himani Sharma, Keshav Raj Paudel, Amlan Chakraborty, Ronan MacLoughlin, Brian G. Oliver, Gaurav Gupta, Poonam Negi, Sachin Kumar Singh, Kamal Dua,
... those have been identified to treat LC include mir-Let7, mir-34a, mir-134, mir-16-1, mir-320a, mir-148a, mir-125a-5p, mir-497, mir-29, mir-133a, and mir-29a-3p. These miRNAs target ...
Tópico(s): Cancer Mechanisms and Therapy
2024 - Elsevier BV | Pathology - Research and Practice