Romina Pallisco, Giacomo Lazzarino, Gabriele Bilotta, Francesca Marroni, Renata Mangione, Miriam Wissam Saab, Maria Violetta Brundo, Alessandra Pittalà, Giuseppe Caruso, Elena Capoccia, Giuseppe Lazzarino, Barbara Tavazzi, Pasquale Bilotta, Angela Maria Amorini,
Notwithstanding the great improvement of ART, the overall rate of successful pregnancies from implanted human embryos is definitely low. The current routine embryo quality assessment is performed only through morphological criteria, which has poor predictive capacity since only a minor percentage of those in the highest class give rise to successful pregnancy. Previous studies highlighted the potentiality of the analysis of metabolites in human embryo culture media, useful for the selection of embryos ...
Tópico(s): Ovarian function and disorders
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Miriam C. Oliveira, Caroline Possa Marroni, Cristina B. Pizarro, Júlia Fernanda Semmelmann Pereira‐Lima, Lígia Maria Barbosa-Coutinho, Nelson Pires Ferreira,
Inactivating mutations of TP53, a tumor suppressor gene, are associated with abnormal cell proliferation. Although p53 expression is common in many human malignancies, p53 protein has seldom been evaluated in pituitary tumors. When detected, the percentage of p53-positive cells is low, and, in general, it is exclusive for invasive lesions. The aim of the present study was to use immunohistochemistry to determine the presence of p53 protein in pituitary adenomas from tumor samples of 163 surgeries ...
Tópico(s): Head and Neck Surgical Oncology
2002 - Associação Brasileira de Divulgação Científica | Brazilian Journal of Medical and Biological Research
Produção Nacional
Revisado por pares
Júlia Fernanda Semmelmann Pereira‐Lima, Caroline Possa Marroni, Cristina B. Pizarro, Lígia Maria Barbosa-Coutinho, Nelson Pires Ferreira, Miriam C. Oliveira,
With the aim of evaluating the relationship between pituitary tumorigenesis and the presence of estrogen receptor-alpha (ERalpha) by immunohistochemistry (IH) and their relevance to patients' clinical presentation, hormonal phenotypes of adenomas, preoperative neuroimaging findings, and the index of cellular replication MIB-1, a study was conducted with material from 91 women and 67 men with pituitary adenomas. The patients had acromegaly (29.7%), Cushing's disease (14.6%), hyperprolactinemic syndrome ( ...
Tópico(s): Adrenal and Paraganglionic Tumors
2004 - Karger Publishers | Neuroendocrinology
Produção Nacional
Revisado por pares
Miriam C. Oliveira, Caroline K. Kramer, Caroline Possa Marroni, Carolina Garcia Soares Leães, Luciana Verçoza Viana, Sérgio Roithman, Alexandre Schmaedecke, Júlia Fernanda Semmelmann Pereira‐Lima,
This article reports a female who presented with bleeding, acquired factor VIII and von Willebrand factor (aFVIII-VWF) deficiency, and central deficiency in the thyroid and adrenal axis (Sheehan’s syndrome). After starting hormone replacement therapy, relief of bleeding manifestations was associated with correction of both FVIII and VWF to normal. This report draws attention to a rare association between the acquired form of von Willebrand disease and hypothyroidism of central origin.
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2008 - SAGE Publishing | Clinical and Applied Thrombosis/Hemostasis