Monika Rhein, Liu Heung Chan, Wolfgang Roether, Peter Schlösser,
226Ra and Ba data are presented for the northeast Atlantic below 2000 m depth from a section of stations 8°S to 46°N obtained by F.S. Meteor in 1981. The precision of the 226Ra data (±1%) allows a resolution of structures in the 226Ra distribution that is comparable to the resolution for Ba and nutrients. Linear property—property correlations in the upper parts of the depth range appear to be uniform within the observational error along the section for 226Ra, Ba [Ba(nmol kg−1) = 3.88 Ra (dpm 100 kg−1) + ...
Tópico(s): Groundwater and Isotope Geochemistry
1987 - Pergamon Press | Deep Sea Research Part A Oceanographic Research Papers
Matthew B. Siegel, Selina Qiuying Liu, Monika A. Davare, Stephen E. Spurgeon, Marc Loriaux, Brian J. Druker, Emma C. Scott, Jeffrey W. Tyner,
// Matthew B. Siegel 1 , Selina Qiuying Liu 1 , Monika A. Davare 1,2 , Stephen E. Spurgeon 1 , Marc M. Loriaux 1 , Brian J. Druker 1,3 , Emma C. Scott 1,* and ...
Tópico(s): Histone Deacetylase Inhibitors Research
2015 - Impact Journals LLC | Oncotarget
Monika Dzieciątkowska, Xin Liu, Astrid P. Heikema, R. Scott Houliston, Alex van Belkum, Elke K. H. Schweda, Michel Gilbert, James C. Richards, Jianjun Li,
Campylobacter jejuni lipooligosaccharide (LOS) can trigger Guillain-Barré syndrome (GBS) due to its similarity to human gangliosides. Rapid and accurate structural elucidation of the LOS glycan of a strain isolated from a GBS patient could help physicians determine the spectrum of anti-ganglioside antibodies likely to be found and therefore provide valuable assistance in establishing an appropriate course of treatment. The ability of implemented mass spectrometry-based approaches in a clinical setting ...
Tópico(s): Bacteriophages and microbial interactions
2008 - American Society for Microbiology | Journal of Clinical Microbiology
Michał Marzec, Monika Kasprzycka, X Liu, Mouna El-Salem, Krzysztof Halasa, Puthiyaveettil N. Raghunath, Robert Bucki, Paweł Włodarski, Mariusz A. Wasik,
Tópico(s): Chronic Lymphocytic Leukemia Research
2007 - Springer Nature | Oncogene
Joe R. Delaney, George L. Sutphin, Ben W. Dulken, Sylvia Sim, Jin R. Kim, Brett Robison, Jennifer Schleit, Christopher J. Murakami, Daniel Carr, Elroy H. An, Eunice Choi, Annie Chou, Marissa Fletcher, Monika Jelic, Bin Liu, Daniel Lockshon, Richard Moller, Diana N. Pak, Qi Peng, Zhao Peng, Kim M. Pham, Michaël Sage, Amrita Solanky, Kristan K. Steffen, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Simon C. Johnson, Chris Raabe, Yousin Suh, Zhongjun Zhou, Xinguang Liu, Brian K. Kennedy, Matt Kaeberlein,
Summary Activation of Sir2 orthologs is proposed to increase lifespan downstream of dietary restriction. Here, we describe an examination of the effect of 32 different lifespan‐extending mutations and four methods of DR on replicative lifespan (RLS) in the short‐lived sir2Δ yeast strain. In every case, deletion of SIR2 prevented RLS extension; however, RLS extension was restored when both SIR2 and FOB1 were deleted in several cases, demonstrating that SIR2 is not directly required for RLS extension. ...
Tópico(s): Adipose Tissue and Metabolism
2011 - Wiley | Aging Cell
Michał Marzec, Monika Kasprzycka, X Liu, Puthiyaveettil N. Raghunath, Paweł Włodarski, Mariusz A. Wasik,
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2006 - Springer Nature | Oncogene
Qian Gao, David Gilbert, Monika Heiner, Fei Liu, Daniele Maccagnola, David Tree,
Modeling across multiple scales is a current challenge in Systems Biology, especially when applied to multicellular organisms. In this paper, we present an approach to model at different spatial scales, using the new concept of Hierarchically Colored Petri Nets (HCPN). We apply HCPN to model a tissue comprising multiple cells hexagonally packed in a honeycomb formation in order to describe the phenomenon of Planar Cell Polarity (PCP) signaling in Drosophila wing. We have constructed a family of related ...
Tópico(s): Bioinformatics and Genomic Networks
2012 - Institute of Electrical and Electronics Engineers | IEEE/ACM Transactions on Computational Biology and Bioinformatics
Paweł Włodarski, Monika Kasprzycka, Xiaobin Liu, Michał Marzec, Erle S. Robertson, Artur Słupianek, Mariusz A. Wasik,
Abstract The study examines the preponderance and mechanism of mammalian target of rapamycin (mTOR) activation in three distinct types of transformed B lymphocytes that differ in expression of the EBV genome. All three types [EBV-immortalized cells that express a broad spectrum of the virus-encoded genes (type III latency; EBV+/III), EBV-positive cells that express only a subset of the EBV-encoded genes (EBV+/I), and EBV-negative, germinal center–derived cells (EBV−)] universally displayed activation ...
Tópico(s): Immune Cell Function and Interaction
2005 - American Association for Cancer Research | Cancer Research
C. R. Gallistel, Monika Krishan, Ye Liu, Reilly Miller, Peter E. Latham,
We present a computational model to explain the results from experiments in which subjects estimate the hidden probability parameter of a stepwise nonstationary Bernoulli process outcome by outcome. The model captures the following results qualitatively and quantitatively, with only 2 free parameters: (a) Subjects do not update their estimate after each outcome; they step from one estimate to another at irregular intervals. (b) The joint distribution of step widths and heights cannot be explained ...
Tópico(s): Philosophy and History of Science
2014 - American Psychological Association | Psychological Review
Monika Joshi, Xin Liu, Chandra P. Belani,
Taxanes are novel microtubule-stabilizing agents and have shown efficacy in non-small cell lung cancer (NSCLC) since the 1990s. Paclitaxel and docetaxel have been used either as single agents or in combination with a platinum compound. The newer generation albumin-bound taxane, nab-paclitaxel, has also shown similar efficacy in advanced NSCLC, both as a single agent and in combination with a platinum compound. Nab-paclitaxel, being Cremophor EL free, appears to have a better toxicity profile than ...
Tópico(s): Lung Cancer Research Studies
2014 - Lippincott Williams & Wilkins | Anti-Cancer Drugs
David Gilbert, Monika Heiner, Fei Liu, Nigel J. Saunders,
In this paper we introduce a technique to encode spatial attributes of dynamic systems using coloured Petri nets and show how it can be applied to biological systems within the spirit of BioModel Engineering. Our approach can be equally applied to qualitative, stochastic, continuous or hybrid models of the same physical system, and can be used as the basis for multiscale modelling. We illustrate our approach with two case studies, one from the continuous and one from the stochastic paradigm. In ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2013 - Springer Science+Business Media | Lecture notes in computer science
Ovidiu Pârvu, David Gilbert, Monika Heiner, Fei Liu, Nigel J. Saunders, Simon Shaw,
This article defines a novel spatial-temporal modelling and analysis methodology applied to a systems biology case study, namely phase variation patterning in bacterial colony growth. We employ coloured stochastic Petri nets to construct the model and run stochastic simulations to record the development of the circular colonies over time and space. The simulation output is visualised in 2D, and sector-like patterns are automatically detected and analysed. Space is modelled using 2.5 dimensions considering ...
Tópico(s): Mathematical Biology Tumor Growth
2015 - Association for Computing Machinery | ACM Transactions on Modeling and Computer Simulation
Ji-Ren Chen, Yanbin Chen, Monika Ziemiańska, Rong Liu, Ziniu Deng, Irena Niedźwiecka-Filipiak, Yanlin Li, Jinxia Jiao, Xingyao Xiong,
Tópico(s): Polysaccharides and Plant Cell Walls
2016 - Springer Science+Business Media | Journal of Plant Growth Regulation
Monika Phelps, J. Liu, James D. Benson, Cara E. Willoughby, J. A. Gilmore, John K. Critser,
Cryopreservation of murine spermatozoa would provide an efficient method for preserving important genotypes. However, to date such methods have resulted in low survivals with significant variability. To address this issue, a series of five experiments was performed to determine the cryobiological characteristics of murine spermatozoa. Experiments 1 and 2 investigated the effect of Percoll separation on the hydraulic conductivity (Lp) of murine spermatozoa. Both Percoll separation and cryoprotective ...
Tópico(s): Reproductive biology and impacts on aquatic species
1999 - Oxford University Press | Biology of Reproduction
Hwa Kyung Nam, Monika Sharma, Jin Liu, Nan Hatch,
Hypophosphatasia is a rare heritable disorder caused by inactivating mutations in the gene (Alpl) that encodes tissue nonspecific alkaline phosphatase (TNAP). Hypophosphatasia with onset in infants and children can manifest as rickets. How TNAP deficiency leads to bone hypomineralization is well explained by TNAP's primary function of pyrophosphate hydrolysis when expressed in differentiated bone forming cells. How TNAP deficiency leads to abnormalities within endochondral growth plates is not yet ...
Tópico(s): Parathyroid Disorders and Treatments
2017 - Frontiers Media | Frontiers in Physiology
Ana C. Reis, Monika Čvančarová, Ying Liu, Markus Lenz, Timm Hettich, Boris A. Kolvenbach, Philippe F.-X. Corvini, Olga C. Nunes,
Tópico(s): Pesticide and Herbicide Environmental Studies
2018 - Springer Science+Business Media | Applied Microbiology and Biotechnology
Sanja Panovska, Monika Korte, Jiabo Liu, Norbert R Nowaczyk,
Abstract Reconstructions of the geomagnetic field on long time scales are important to understand the geodynamo processes in the Earth's core. The geomagnetic field exhibits a range of variations that vary from normal, dipole‐dominated secular variation to geomagnetic excursions and reversals. These transitional events are associated with significant directional deviations and very low intensities. Here we present a new, global geomagnetic field model spanning the period 70–15 ka (GGFSS70) that includes ...
Tópico(s): Geological formations and processes
2021 - Wiley | Journal of Geophysical Research Solid Earth
S. T. Davies, Yubing Hu, Nan Jiang, Jeff Blyth, Monika Kamińska, Yunzheng Liu, Ali K. Yetisen,
Abstract As populations expand worldwide, medical care will need to diversify its data collection techniques to be able to provide adequate healthcare to global populations, this can be achieved through point‐of‐care analysis by wearable analytical devices. Holographic sensors are reusable optical biosensors with the capability to continuously monitor variations, generating the prospect of in vivo monitoring of patient homeostasis. Holographic optical sensors have emerged as an opportunity for low ...
Tópico(s): Analytical Chemistry and Sensors
2021 - Wiley | Advanced Functional Materials
Wenya Du, Geng Liu, Na Shi, Dongmei Tang, Paweł E. Ferdek, Monika A. Jakubowska, Shiyu Liu, Xinyue Zhu, Jiayu Zhang, Linbo Yao, Xiongbo Sang, Sailan Zou, Tingting Liu, Rajarshi Mukherjee, David N. Criddle, Xiaofeng Zheng, Qing Xia, Per‐Olof Berggren, Wendong Huang, Robert Sutton, Yan Tian, Wei Huang, Xianghui Fu,
Acute pancreatitis (AP) is a common digestive disease without specific treatment, and its pathogenesis features multiple deleterious amplification loops dependent on translation, triggered by cytosolic Ca
Tópico(s): Phagocytosis and Immune Regulation
2022 - Elsevier BV | Molecular Therapy
Neil S. Wenger, Robert K. Oye, Norman A. Desbiens, Russell S. Phillips, Joan M. Teno, Alfred F. Connors, Honghu Liu, Monika F. Zemsky, Peter S. Kussin,
... Joan M. Teno, Alfred F. Connors, Jr., Honghu Liu, Monika F. Zemsky, and Peter KussinThe SUPPORT InvestigatorsUniversity of ...
Tópico(s): Emergency and Acute Care Studies
1996 - University of Chicago Press | The Journal of Clinical Ethics
Yajing Liu, Rachel Martin-Trevino, Shang Li, April Davis, Max S. Wicha, Suling Liu, Monika L. Burness,
... Trevino, Li Shang, April Davis, Max Wicha, Suling Liu, Monika Burness. Histone deacetylase inhibitors sensitize cancer stem cells ...
Tópico(s): Cancer-related Molecular Pathways
2015 - American Association for Cancer Research | Cancer Research
Yajing Liu, Monika L. Burness, Rachel Martin-Trevino, Joey Guy, Shoumin Bai, Ramdane Harouaka, Michael Brooks, Shang Li, Alexandra Fox, Tahra Luther, April Davis, Trenton L. Baker, Justin A. Colacino, Shawn G. Clouthier, Zhi-Ming Shao, Max S. Wicha, Suling Liu,
PARP inhibitors have shown promising results in early studies for treatment of breast cancer susceptibility gene (BRCA)-deficient breast cancers; however, resistance ultimately develops. Furthermore, the benefit of PARP inhibitors (PARPi) in triple-negative breast cancers (TNBC) remains unknown. Recent evidence indicates that in TNBCs, cells that display "cancer stem cell" properties are resistant to conventional treatments, mediate tumor metastasis, and contribute to recurrence. The sensitivity of ...
Tópico(s): CRISPR and Genetic Engineering
2016 - American Association for Cancer Research | Clinical Cancer Research
Mouna El-Salem, Puthiyaveettil N. Raghunath, Michał Marzec, Xiaobin Liu, Monika Kasprzycka, Erle S. Robertson, Mariusz A. Wasik,
Tópico(s): Mast cells and histamine
2009 - Elsevier BV | American Journal Of Pathology
Jianbin Du, Monika J. Stankiewicz, Yang Liu, Qing Xi, Jonathan E. Schmitz, Julie Lekstrom-Himes, Steven J. Ackerman,
GATA-1 and the ets factor PU.1 have been reported to functionally antagonize one another in the regulation of erythroidversus myeloid gene transcription and development. The CCAAT enhancer binding protein ε (C/EBPε) is expressed as multiple isoforms and has been shown to be essential to myeloid (granulocyte) terminal differentiation. We have defined a novel synergistic, as opposed to antagonistic, combinatorial interaction between GATA-1 and PU.1, and a unique repressor role for certain C/EBPε isoforms ...
Tópico(s): Eosinophilic Disorders and Syndromes
2002 - Elsevier BV | Journal of Biological Chemistry
Silke Walter, Klaus Faßbender, Erich Gulbins, Yang Liu, Monika Rieschel, Monika Herten, Thomas Bertsch, Britta Engelhardt,
In this study, we explored the therapeutic targets of the glycosylation processing inhibitor, castanospermine (CAST), in murine passive transfer experimental autoimmune encephalomyelitis (EAE), a model disease of multiple sclerosis. By using lymphocytic–endothelial adhesion and transmigration assays, FACScan and Western blotting, we defined the effects of CAST on expression, function and signal transduction of glycoproteins crucial in the pathophysiology of this disease. CAST prevented clinical signs ...
Tópico(s): Immunotherapy and Immune Responses
2002 - Elsevier BV | Journal of Neuroimmunology
Monika E. Hegi, Lili Liu, James G. Herman, Roger Stupp, Wolfgang Wick, Michael Weller, Minesh P. Mehta, Mark R. Gilbert,
Resistance to alkylating agents via direct DNA repair by O 6 -methylguanine methyltransferase (MGMT) remains a significant barrier to the successful treatment of patients with malignant glioma. The relative expression of MGMT in the tumor may determine response to alkylating agents, and epigenetic silencing of the MGMT gene by promoter methylation plays an important role in regulating MGMT expression in gliomas. MGMT promoter methylation is correlated with improved progression-free and overall survival ...
Tópico(s): Histone Deacetylase Inhibitors Research
2008 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Deborah A. Levine, Cora E. Lewis, O. Dale Williams, Monika M. Safford, Kiang Liu, David A. Calhoun, Yongin Kim, David R. Jacobs, Catarina I. Kiefe,
Although the variability of cardiovascular disease mortality by geography, race, and sex is well known, less is known about risk factor variation. We assessed 20-year incidence of hypertension, a cardiovascular disease risk factor, across 4 US urban areas and by race-sex. Among 3436 eligible adults 18 to 30 years of age when recruited in 1985 to 1986 in the community-based Coronary Artery Risk Development in Young Adults (CARDIA) cohort, we examined 20-year cumulative incidence of hypertension (systolic ...
Tópico(s): Sodium Intake and Health
2010 - Lippincott Williams & Wilkins | Hypertension
Andrew K. Ottens, Firas Kobeissy, Brian F. Fuller, Ming Chen Liu, Monika W. Oli, Ronald L. Hayes, Kevin Wang,
Neuroproteomics entails wide-scope study of the nervous system proteome in both its content and dynamics. The field employs high-end analytical mass spectrometry and novel high-throughput antibody approaches to characterize as many proteins as possible. The most common application has been differential analysis to identify a limited set of highly dynamic proteins associated with injury, disease, or other altered states of the nervous system. Traumatic brain injury (TBI) is an important neurological ...
Tópico(s): Hemoglobin structure and function
2007 - Elsevier BV | Progress in brain research
Paweł Włodarski, Qian Zhang, Xiaobin Liu, Monika Kasprzycka, Michał Marzec, Mariusz A. Wasik,
Protein-tyrosine phosphatase SHP-1 is the key negative regulator of numerous signaling pathways. SHP-1 is expressed in the hematopietic and epithelial cells as two structurally similar mRNA transcripts controlled by two different promoters designated P2 and P1, respectively. Whereas the transcriptional regulation of the SHP-1 gene P1 promoter has been partially elucidated, the structure and functional control of the P2 promoter remain unknown despite the critical role played by SHP-1 in the normal ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2007 - Elsevier BV | Journal of Biological Chemistry
Michał Marzec, Xiaobin Liu, Monika Kasprzycka, Agnieszka K. Witkiewicz, Puthiyaveettil N. Raghunath, Mouna El-Salem, Erle S. Robertson, Niels Ødum, Mariusz A. Wasik,
We examined functional status, activation mechanisms, and biologic role of the mTORC1 signaling pathway in malignant CD4+ T cells derived from the cutaneous T-cell lymphoma (CTCL). Whereas the spontaneously growing CTCL-derived cell lines displayed persistent activation of the TORC1 as well as the PI3K/Akt and MEK/ERK pathways, the IL-2–dependent cell lines activated the pathways in response to IL-2 and IL-15 but not IL-21. Activation of mTORC1 and MEK/ERK was nutrient dependent. The mTORC1, PI3K/ ...
Tópico(s): Mast cells and histamine
2007 - Elsevier BV | Blood