Shiraj Sen, Justin Call, Kyriakos P. Papadopoulos, F. Donelson Smith, J Mcdermott, Edward van der Horst, Aaron Weitzman,
... doses where severe CRS was observed with prior VISTA agents. Both mono and combo therapy have been generally well tolerated. ...
Tópico(s): Immunotherapy and Immune Responses
2024 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Produção Nacional
Revisado por pares
Carlos Alberto Hussni, H Wißdorf, José Luiz de Mello Nicolett,
... se a análise quadro a quadro, estes apresentando vista lateral em movimento. Nesta fase foram registrados os momentos de apoio (mono, bi ou tripedais) bem como os momentos de ...
Tópico(s): Soil Mechanics and Vehicle Dynamics
1996 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Rural
Matthias Freund, Sebastian Schenker, Alexandru Zamfir, Svetlana B. Tsogoeva,
Lewis and Bronsted base catalysis are rapidly growing areas in organocatalysis. Numerous binaphthyl-derived chiral base catalysts has been developed over the last years. Recent progress in the chiral Lewis and Bronsted base catalysis has been reviewed with a focus being placed on mono-functional catalysts, including primary and secondary diamines, guanidines, phosphines and phosphineoxides; bi- and multifunctional catalysts, covering secondary and/or tertiary amine and phosphine derivatives assisted ...
Tópico(s): Asymmetric Synthesis and Catalysis
2011 - Bentham Science Publishers | Current Organic Chemistry
Produção Nacional
Patrícia Izar, Eduardo D. Ramos-da-Silva, Briseida D. de-Resende, Eduardo Β. Ottoni,
... no emparentadas. Los criticos de este punto de vista advierten sobre la falta de evidencia de este comportamiento en varias especies de primates, de ahi la relevancia de los relatos de observacion de eventos de infanticidio. En este trabajo reportamos un caso de infanticidio en un grupo silvestre de monos capu- chinos (Cebus nigritus).
Tópico(s): Evolutionary Psychology and Human Behavior
2007 - SAREM | Mastozoología neotropical
David Wilkie, Bryan Curran, Richard Tshombe, Gilda A. Morelli,
... se utilizan estimaciones de producción cinegética), pero en vista de que la población humana continúa incrementando, algunos antílopes podrían ser sobre‐cazados. Las poblaciones de primates no parecen estar amenazadas a corto plazo en aquellas áreas donde los cazadores con arco capturan los monos, pero un incremento en esta actividad especializada en ...
Tópico(s): Rangeland Management and Livestock Ecology
1998 - Wiley | Conservation Biology
Xin Chen, Xiaomin Song, Kang Li, Tong Zhang,
... CTLA-4, TIM-3, Lag-3, TIGIT, CD73, VISTA, B7-H3) in the tumor microenvironment is an important mechanism that restrains effector T cells from the anti-tumor activity. To date, immune checkpoint antibodies have demonstrated significant clinical benefits for cancer patients treated with mono- or combination immunotherapies. However, many tumors do not ...
Tópico(s): Immune Cell Function and Interaction
2019 - Frontiers Media | Frontiers in Immunology
... pero siguen siendo pobres desde el punto de vista del desarrollo. Se analizan las distorsiones por las cuales las economias extractivistas desembocan en varias «enfermedades» y se dan ejemplos latinoamericanos. Esto incluye procesos tales como la dependencia de capital y tecnologias, la mentalidad mono exportadora y la subordinacion a mercados globales. Se ...
Tópico(s): Science, Technology, and Education in Latin America
2016 - Universidad Colegio Mayor de Cundinamarca | Tabula rasa
Produção Nacional
Revisado por pares
Danie Martini Sanchotene, Nelson Diehl Kruse, Luis Antônio de Avila, S.L.O. Machado, G.A. Nicolodi, Sylvio Henrique Bidel Dornelles,
... sobre a atividade da enzima citocromo P-450 mono-oxigenase e que esta é responsável pela ativação do clomazone, buscam-se outros produtos que possam ser utilizados como protetores. Em vista disso, o objetivo deste experimento foi avaliar o ...
Tópico(s): Allelopathy and phytotoxic interactions
2010 - Sociedade Brasileira da Ciência das Plantas Daninhas | Planta Daninha
Cheon Ho Park, Sang Soon Byun, Jin Yong An, Sun Hyung Ha, Hye Rim Han, Nu Ri Kang, Beom Yong Park, Eun Ah Lee, Hyunsun Park, Jin-San Yoo, Weon Sup Lee,
... showed increased expression of VISTA, suggesting that anti-VISTA therapeutics can help to treat the patients who do not respond well to other immuno-oncology drugs. We are developing PMC-309 as a next generation immuno-oncology (IO) agent, which can convert immunologically cold into hot tumors as a mono- or combo- therapy with other IO agent. Citation Format: Cheon Ho Park, Sang Soon Byun, Jin Yong An, Sun Hyung Ha, Hye Rim Han, Nu Ri Kang, Beom Yong Park, Eun Ah Lee, Hyun Sun Park, Jin-San Yoo, Weon Sup Lee. PMC309, a highly selective anti-VISTA antibody enhances T cell activation through blocking the ...
Tópico(s): Chemokine receptors and signaling
2021 - American Association for Cancer Research | Cancer Research
Maria Christodoulou, Apostolos Zaravinos,
... presently being used in the clinical setting as mono- or combinatorial therapy against various cancer types. Methods−Primary publications with results between January 2014 and December 2019 were investigated on PubMed. ClinicalTrials.gov was screened for finding phase I/II/III cancer trials on the use of new immune checkpoint targets, including LAG-3, TIM-3, TIGIT, and VISTA, which are active (recruiting or not) or completed. ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2019 - Begell House | Critical Reviews in Immunology
Youzhou Tang, Ying Zhang, Xinyu Li, Ruoyao Xu, Ying Ji, Jishi Liu, Jianye Liu, Quan Zhuang, Hao Zhang,
... composition and elucidate the potential upstream monocyte/macrophage (Mono/MΦ) initiating the auto‐immune response. After the ... and spatial transcriptome, we identified differential subsets of Mono/MΦ and demonstrated that they exhibit temporal expression ... the function experiments, we found that the APOE+ Mono may be compensatorily increased in LN, and the ... of APOE. Furthermore, how do the LN‐specific Mono/MΦ transport in and out the glomerulus to ... serve as a ‘green channel’ for LN‐specific Mono/MΦ. Conclusions In LN, APOE+ Mono are compensatorily ...
Tópico(s): IL-33, ST2, and ILC Pathways
2023 - Springer Science+Business Media | Clinical and Translational Medicine
Mathias Uhlén, Erik Björling, Charlotta Agaton, Cristina Al‐Khalili Szigyarto, Bahram Amini, Elisabet Andersen, Ann‐Catrin Andersson, Pia Angelidou, Anna Asplund, Caroline Asplund, Lisa Berglund, Kristina Bergström, Harry Brumer, Dijana Cerjan, Marica Ekström, Adila El‐Obeid, Cecilia Eriksson, Linn Fagerberg, Ronny Falk, Jenny Fall, Mattias Forsberg, Marcus Björklund, Kristoffer Gumbel, Asif Halimi, Inga Hallin, Carl Hamsten, Marianne Hansson, My Hedhammar, Görel Hercules, Caroline Kampf, Karin Larsson, Mats Lindskog, Wald Lodewyckx, J. Lund, Joakim Lundeberg, Kristina Magnusson, Erik Malm, Peter Nilsson, Jenny Ödling, Per Oksvold, Ing‐Marie Olsson, Emma Öster, Jenny Ottosson, Linda Paavilainen, Anja Persson, Rebecca Rimini, Johan Rockberg, Marcus Runeson, Åsa Sivertsson, Anna Sköllermo, Johanna Stéen, Maria Stenvall, Fredrik Sterky, Sara Strömberg, Mårten Sundberg, Hanna Tegel, Samuel Tourle, Eva Wahlund, Annelie Waldén, Jinghong Wan, Henrik Wernérus, Joakim Westberg, Kenneth Wester, Ulla Wrethagen, Lan Xu, Sophia Hober, Fredrik Pontén,
... automated slide-scanning system, ScanScope T2 (Aperio Technologies, Vista, CA). For each antibody 576 digital images were ... a human proteome atlas: high-throughput generation of mono-specific antibodies for tissue profiling.Proteomics. 2005; (in ... a human proteome atlas: high-throughput generation of mono-specific antibodies for tissue profiling.Proteomics. 2005; (in ... a human proteome atlas: high-throughput generation of mono-specific antibodies for tissue profiling.Proteomics. 2005; (in ...
Tópico(s): Advanced Biosensing Techniques and Applications
2005 - Elsevier BV | Molecular & Cellular Proteomics
Antoine Dumoulin, Lois R. Manning, W. Terry Jenkins, Robert M. Winslow, James M. Manning,
... gel and purified using Geneclean (BIO 101, Inc., Vista, CA). During the second amplification step, the three ... Scopus (22) Google Scholar), and subsequently on a Mono S column (Pharmacia) attached to a FPLC system. ... be pure by chromatography on a Pharmacia FPLC Mono S column. It showed one sharp band upon ...
Tópico(s): Erythrocyte Function and Pathophysiology
1997 - Elsevier BV | Journal of Biological Chemistry
Carles Monereo i Font, Antoni Badia,
Resumen: Se realiza una aportación desde un punto de vista psicoeducativo a la definición y caracterización de la noción de competencia informacional, a su enseñanza y aprendizaje en la educación escolar, y a la formación de los profesionales de la información.En el primer apartado, se define una persona competente como aquella que es capaz de resolver adecuadamente un conjunto de problemas característicos de una determinada práctica social y comunitaria.Seguidamente, tomando como base esta definición, ...
Tópico(s): Innovative Teaching and Learning Methods
2012 - Spanish National Research Council | Revista española de Documentación Científica
... Imaging Research (STIR)/Virtual International Stroke Trials Archive (VISTA) group8 analyzes LVO predictors in patients receiving reperfusion ... BC, et al; Stroke Imaging Research (STIR) and VISTA-Imaging Investigators. Acute stroke imaging research roadmap III ...
Tópico(s): Stroke Rehabilitation and Recovery
2017 - Lippincott Williams & Wilkins | Stroke
Mathias Uhlén, Per Oksvold, Cajsa Älgenäs, Carl Hamsten, Linn Fagerberg, Daniel Klevebring, Emma Lundberg, Jacob Odeberg, Fredrik Pontén, Tadashi Kondo, Åsa Sivertsson,
... Aperio Scan Scope CS slide scanner (Aperio Technologies, Vista, CA) system was used to capture digital whole ... a human proteome atlas: High-throughput generation of mono-specific antibodies for tissue profiling.Proteomics. 2005; 5: ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2011 - Elsevier BV | Molecular & Cellular Proteomics
Thomas Schwartz, Ky Lowenhaupt, Yang‐Gyun Kim, Liyun Li, Bernard A. Brown, Alan Herbert, Alexander Rich,
... specifically to Z-DNA, opens up a new vista and invites the investigation of the similarities and ... finally purified by cation-exchange chromatography on a Mono S HR5/5 column (Amersham Pharmacia Biotech). Proteins ... chromatographic behavior over previous Zαconstructs, purifying from a Mono S cation-exchange column homogeneously as a sharp ...
Tópico(s): RNA and protein synthesis mechanisms
1999 - Elsevier BV | Journal of Biological Chemistry
Genoveva Trejo-Macías, Miguel Ángel Mosqueda-Cabrera, Luis García‐Prieto, Alejandro Estrada,
... de las heces de las 2 especies de monos aulladores de México: Alouatta palliatamexicana Merriam, 1902 (Los Tuxtlas, Veracruz) y Alouatta pigra Lawrence, 1933 (Palenque, Chiapas). El trabajoincluye microfotografías de algunos rasgos diagnósticos del parásito. Su identificación se basó en la presencia de unaplaca cefálica cuadrangular, que diferencia esta especie de las otras 7 del subgénero Trypanoxyuris. En los huevos deT. (T.) minutus se observaron 3 crestas longitudinales equidistantes, que en vista apical forman un contorno triangularcon las esquinas redondeadas.
Tópico(s): Rabbits: Nutrition, Reproduction, Health
2011 - National Autonomous University of Mexico | Revista Mexicana de Biodiversidad
Produção Nacional
Patrícia Rodrigues, Marcus Vinícius Lunguinho,
... marcador pragmático, expressando surpresa ou o ponto de vista contrário do falante. A hipótese defendida no trabalho é a de que essas leituras estão associadas a duas estruturas sintáticas distintas: as sentenças com capaz epistêmico são bioracionais, ao passo que as sentenças em que capaz funciona como marcador pragmático são mono-oracionais. Com base nas propostas de Speas e ...
Tópico(s): Syntax, Semantics, Linguistic Variation
2019 - UNIVERSIDADE FEDERAL DE MINAS GERAIS | Revista de Estudos da Linguagem
Médica de Bogotá Revista, Sérgio Alberto,
... sus dos hemisferios tan esencialmente diferentes, a primera vista, con respecto a los de los primates.Arrastrados por el entusiasmo algo tendencioso que desperto, como decia antes, la escuela de Darwin, los investigadores se dedicaron, entonces, unicamente a la morfologia cerebral de los monos inferiores y de los antropoides, con el objeto ... practicamente desconocidos hasta entonces desde el punto de vista cerebral, de hombres de las razas mas variadas asi como de hombres celebres, sabios, retrasados, microcefalos, enanos, asesinos.De todos aquellos trabajos se desprende poco a poco la similitud que se ignoraba, por asi decirlo, de los surcos y lobulos cerebrales de los monos con los del cerebro humano; asi se establecieron ...
Tópico(s): Neuroscience, Education and Cognitive Function
2007 - Universidad de Los Andes | Revista de Estudios Sociales
Pablo Ramı́rez, Antonio Ríos, José Yélamos, Antonio Muñoz, Pascual Parrilla,
... el riesgo de xenozoonosis. Desde el punto de vista inmunológico, la condición necesaria sería que el xenorrechazo ... fisiológica de estos órganos porcinos trasplantados en los monos durante estos períodos. En cuanto a las barreras ...
Tópico(s): Neuroethics, Human Enhancement, Biomedical Innovations
2002 - Elsevier BV | Cirugía Española
Chun‐Ming Huang, K. Wade Foster, Tivanka S. DeSilva, Jianfeng Zhang, Zhongkai Shi, Nabiha Yusuf, Kent R. Van Kampen, Craig A. Elmets, De-chu C. Tang,
... scale proteomic initiatives have opened a new research vista in analysis of protein function. Although two-dimensional ... laser shots. All peptide samples were measured as mono-isotopic masses, and autolytic peaks of trypsin were ...
Tópico(s): Bee Products Chemical Analysis
2003 - Elsevier BV | Journal of Investigative Dermatology
... contemporaneous incidence of ALL also developed in Sierra Vista, Arizona (Cochise County Health Department 2004). Other clusters ... galaxy of highly bioactive natural products. Riddelliine, senkirkine, mono-crotaline, retronecine, heliotridine, jacoline, jacozine, jacobine, seneciphylline, and ...
Tópico(s): Acute Lymphoblastic Leukemia research
2005 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Tatjana Degenhardt, Merja Matilainen, Karl‐Heinz Herzig, Thomas W. Dunlop, Carsten Carlberg,
... homogenized in lysing matrix A tubes (Bio 101, Vista, CA) using a Fast Prep FP120 machine (Savant ... by electrophoresis through 8% non-denaturing polyacrylamide gels (mono- to bisacrylamide ratio 19:1) in 0.5× ...
Tópico(s): Metabolism, Diabetes, and Cancer
2006 - Elsevier BV | Journal of Biological Chemistry
... los serotipos 1–3, aislados en Inglaterra. En vista de estos hallazgos, se propone agrupar las cepas ... ninguno de los tipos de adenovirus conocidos del mono, de la vaca, del perro, gallina y del ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
1969 - Wiley | Zentralblatt für Veterinärmedizin Reihe B
Steven Siqing Wang, Ratha Mahendran, Dennis L. Miller,
... was isolated using glassmilk (GeneClean II, Bio 101, Vista, CA). These DNAs were reamplified by PCR using ...
Tópico(s): Genomics and Phylogenetic Studies
1999 - Elsevier BV | Journal of Biological Chemistry
Katja Niesel, Michael Schulz, Julian Anthes, Tijna Alekseeva, Jadranka Macas, Anna Salamero‐Boix, Aylin Möckl, T. Oberwahrenbrock, Marco Lolies, Stefan Stein, Karl H. Plate, Yvonne Reiss, Franz Rödel, Lisa Sevenich,
... expression of the co-regulatory factor Cd112 and Vista was significantly higher in TAM-MG compared with ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2021 - Springer Nature | EMBO Molecular Medicine
Este artículo repone los diferentes puntos de vista teóricos sobre la ortodoxia y la heterodoxia en las relaciones entre etnografía y cine a través del estudio del film Nosotros los monos (Edmund Valladares, 1971). Se desarrollan los conceptos de Karl Heider, Jay Ruby, David MacDougall y Marc Henri Piault, entre otros; como asimismo se ...
Tópico(s): Literary and Cultural Studies
2015 - | Aceno - Revista de Antropologia do Centro-Oeste
Xinyu Xie, Joy Thomas, Chang-Tang Chang, Hong Tao,
... room temperature. Gas phase adsorption isotherms confirmed the mono layer adsorption behavior. The kinetics models evaluated that the external mass transfer was the rate limiting step for surface adsorption. The thermodynamic study manifested that the adsorption reaction was spontaneous and exothermic. The proposed mechanism of adsorption was the act of physisorption which enriched the adsorbents reusability. This research work provides a futuristic vista to design mineralized Fe-MOFs composites for an ...
Tópico(s): Adsorption and biosorption for pollutant removal
2021 - American Scientific Publishers | Journal of Nanoscience and Nanotechnology
Produção Nacional
Revisado por pares
<p>Historicamente, o leitor é construído como mono ou polifônico, conforme sejam os valores vinculados às noções de conflito e heterogeneidade em sala de aula. Este texto examina três momentos da leitura na escola, concentrando-se na pedagogia da possibilidade, uma concepção pós-moderna vista mais como uma atitude do que como abordagem.</p>
Tópico(s): Cultural, Media, and Literary Studies
2002 - UNIVERSIDADE TECNOLÓGICA FEDERAL DO PARANÁ | Revista de Letras