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Artigo Acesso aberto Revisado por pares

Bjørn Holst, Anette W. Bruun, Morten C. Kielland‐Brandt, Jakob R. Winther,

Using carboxypeptidase Y in Saccharomyces cerevisiae as a model system, the in vivo relationship between protein folding and N-glycosylation was studied. Seven new sites for N-glycosylation were introduced at positions buried in the folded protein structure. The level of glycosylation of such new acceptor sites was analysed by pulse-labelling under two sets of conditions that are known to reduce the rate of folding: (i) addition of dithiothreitol to the growth medium and (ii) introduction of deletions ...

Tópico(s): Protein Structure and Dynamics

1996 - Springer Nature | The EMBO Journal

Artigo Revisado por pares

Peter Lüchau,

... critique and suggestions: Peter B. Andersen, Lars Kjær Bruun, and Morten Warmind in the History of Religions Section at ...

Tópico(s): Religion, Spirituality, and Psychology

2007 - Taylor & Francis | Journal of Contemporary Religion

Artigo Revisado por pares

Kun Zhu, Sander Bruun, Morten Larsen, Ronnie N. Glud, Lars Stoumann Jensen,

The availability and spatial distribution of oxygen (O) in agricultural soil are controlling factors in the production and emission of nitrous oxide (NO) to the atmosphere, but most experiments investigating the effects of various factors on NO emissions in soil have been conducted without determining the content and distribution of O. This complicates data interpretation and leads to speculative conclusions about which nitrogen transformation processes are responsible for NO production. Using an ...

Tópico(s): Marine and coastal ecosystems

2014 - Wiley | Journal of Environmental Quality

Artigo Revisado por pares

Kun Zhu, Sander Bruun, Morten Larsen, Ronnie N. Glud, Lars Stoumann Jensen,

Soil oxygen (O2) availability influences nitrification and denitrification, the major biological processes responsible for nitrous oxide (N2O) production and emissions from soil. In this study O2-specific planar optodes were used to visualise O2 distribution with high spatial and temporal resolution in soils in which the same amount of solid fraction of pig manure had been distributed in three different ways (mixed, layered, single patch) and which were maintained at a water potential of −5 kPa (corresponding ...

Tópico(s): Peatlands and Wetlands Ecology

2015 - Elsevier BV | Soil Biology and Biochemistry

Carta Acesso aberto Revisado por pares

Camilla Fløjgaard, Hans Henrik Bruun, Morten D. D. Hansen, Jacob Heilmann‐Clausen, Jens‐Christian Svenning, Rasmus Ejrnæs,

Increasing species richness of light demanding species in forests may not be a conservation concern if we accept a macroecological and evolutionary baseline for biodiversity. Most of the current biodiversity in Europe has evolved in the Pleistocene or earlier, and in ecosystems markedly influenced by dynamic natural processes, including grazing. Many threatened species are associated with high-light forest environments such as forest glades and edges, as these have strongly declined at least partially ...

Tópico(s): Forest Management and Policy

2017 - Wiley | Global Change Biology

Artigo Acesso aberto Revisado por pares

Kristoffer Sølvsten Burgdorf, Jacob Simonsen, Anna Sundby, Klaus Rostgaard, Ole Birger Pedersen, Erik Sørensen, Kaspar René Nielsen, Mie Topholm Bruun, Morten Frisch, Gustaf Edgren, Christian Erikstrup, Henrik Hjalgrim, Henrik Ullum,

Blood transfusion is an essential component of a modern healthcare system. Because knowledge about blood donor demography may inform the design of strategies for donor recruitment and retention, we used nationwide registers to characterize the entire population of blood donors in Denmark in 2010.The study population comprised all Danes in the age range eligible for blood donation (N = 3,236,753) at the end of 2010. From the Scandinavian Donations and Transfusions (SCANDAT) register, we identified 174, ...

Tópico(s): Blood transfusion and management

2017 - Public Library of Science | PLoS ONE

Artigo Revisado por pares

Karin Due Bruun, Morten Rune Blichfeldt‐Eckhardt, Henrik Bjarke Vægter, Jørgen Lauridsen, Kirstine Amris, Palle Toft,

Abstract Objective This study explores dose–response relationships when treating fibromyalgia with low-dose naltrexone. Design A single-blinded clinical trial was carried out using the “up-and-down” method. Subjects Subjects included women with a diagnosis of fibromyalgia aged 18–60 years who had been referred to treatment at a public pain clinic at a Danish university hospital. Methods The test doses were in the range 0.75–6 mg, and the dosing interval was 0.75 mg. The method was sequential and ...

Tópico(s): Workplace Health and Well-being

2020 - Oxford University Press | Pain Medicine

Artigo Acesso aberto Revisado por pares

Peter Bruun Jordal, Morten Simonsen Dueholm, Poul Larsen, Steen V. Petersen, Jan J. Enghild, Gunna Christiansen, Peter Højrup, Per Halkjær Nielsen, Daniel E. Otzen,

ABSTRACT Until recently, extracellular functional bacterial amyloid (FuBA) has been detected and characterized in only a few bacterial species, including Escherichia coli , Salmonella , and the gram-positive organism Streptomyces coelicolor . Here we probed gram-positive bacteria with conformationally specific antibodies and revealed the existence of FuBA in 12 of 14 examined mycolata species, as well as six other distantly related species examined belonging to the phyla Actinobacteria and Firmicutes . Most ...

Tópico(s): Bacterial biofilms and quorum sensing

2009 - American Society for Microbiology | Applied and Environmental Microbiology

Artigo Revisado por pares

Morten Bruun-Rasmussen, Knut Bernstein, Catherine Chronaki,

During the past 10-15 years, Regional Health Care Networks (RHCN) have been established in many regions throughout the world. RHCN build on well-known techniques, methodologies and appropriate standards. Most of the European Countries today have set up IT strategic plans that focus on the establishment of RHCN. The benefits of having access to all relevant information are tremendous and contribute to cost-effective and coherent health services. By the rapid spread and use of Internet, technology ...

Tópico(s): Business Strategy and Innovation

2003 - Elsevier BV | International Journal of Medical Informatics

Artigo Revisado por pares

Alireza Dolatshahi‐Pirouz, Kristian Rechendorff, Mads Bruun Hovgaard, Morten Foss, J. Chevallier, Flemming Besenbacher,

The adsorption of bovine serum albumin (BSA) on platinum surfaces with a root-mean-square roughness ranging from 1.49 nm to 4.62 nm was investigated using quartz crystal microbalance with dissipation (QCM-D). Two different BSA concentrations, 50 μg/ml and 1 mg/ml, were used, and the adsorption studies were complemented by monitoring the antibody interaction with the adsorbed BSA layer. The adsorption process was significantly influenced by the surface nano-roughness, and it was observed that the surface ...

Tópico(s): Adhesion, Friction, and Surface Interactions

2008 - Elsevier BV | Colloids and Surfaces B Biointerfaces

Artigo Revisado por pares

T. Jensen, Thomas Jakobsen, Jørgen Baas, Jens Vinge Nygaard, Alireza Dolatshahi‐Pirouz, Mads Bruun Hovgaard, Morten Foss, Cody Bünger, Flemming Besenbacher, Kjeld Søballé,

Abstract It is well established in the field of biomaterials that hydroxyapatite (HA) may provide interesting osteoconductive properties. In this study, we investigated the osseointegrational effect of a 50/50 vol % composite of HA nanoparticles and poly‐ D , L ‐lactic acid (PDLLA) coated on model titanium bone implants in an in vivo animal model. The aim is to evaluate how the addition of HA to PDLLA may improve the bone formation and initial fixation of the implant. Two titanium implants coated with ...

Tópico(s): Orthopaedic implants and arthroplasty

2010 - Wiley | Journal of Biomedical Materials Research Part A

Artigo Revisado por pares

Kristian Rechendorff, Mads Bruun Hovgaard, Morten Foss, Flemming Besenbacher,

The influence of nanometer scale surface roughness on the frequency and dissipation responses of a quartz crystal microbalance operating in a liquid environment has been investigated by exposing quartz crystals, with a rough tantalum coating, to water solutions with varying concentrations of sucrose. A clear correlation between the measured surface roughness and the frequency shift is observed, while the shift in the dissipation factor is nearly unaffected by an increase in surface roughness. The ...

Tópico(s): Mechanical and Optical Resonators

2007 - American Institute of Physics | Journal of Applied Physics

Artigo Revisado por pares

Kristian Rechendorff, Mads Bruun Hovgaard, Morten Foss, Vladimir P. Zhdanov, Flemming Besenbacher,

Using quartz crystal microbalance with dissipation and ellipsometry, we show that during adsorption of fibrinogen on evaporated tantalum films the saturation uptake increases with increasing root-mean-square roughness (from 2.0 to 32.9 nm) beyond the accompanying increase in surface area. This increase is attributed to a change in the geometrical arrangement of the fibrinogen molecules on the surface. For comparison, the adsorption of a nearly globular protein, bovine serum albumin, was studied as ...

Tópico(s): Material Dynamics and Properties

2006 - American Chemical Society | Langmuir

Artigo Acesso aberto Revisado por pares

Charlotte Bay Hasager, R. J. Barthelmie, Merete Bruun Christiansen, Morten Nielsen, S. C. Pryor,

Abstract Offshore wind resources are quantified from satellite synthetic aperture radar (SAR) and satellite scatterometer observations at local and regional scale respectively at the Horns Rev site in Denmark. The method for wind resource estimation from satellite observations interfaces with the wind atlas analysis and application program (WAsP). An estimate of the wind resource at the new project site at Horns Rev is given based on satellite SAR observations. The comparison of offshore satellite ...

Tópico(s): Tropical and Extratropical Cyclones Research

2006 - Wiley | Wind Energy

Artigo Revisado por pares

Christian Nøhr, Stig Kjær Andersen, Søren Vingtoft, Knut Bernstein, Morten Bruun-Rasmussen,

Tópico(s): Electronic Health Records Systems

2004 - Elsevier BV | International Journal of Medical Informatics

Artigo Revisado por pares

Knut Bernstein, Morten Bruun-Rasmussen, Søren Vingtoft, Stig Kjær Andersen, Christian Nøhr,

The Danish Health IT strategy [Danish Ministry of Interior and Health, National Strategy for IT in the Health Sector 2003–2007, Copenhagen, 2003 (in Danish). http://www.im.dk/publikationer/itstrategi/itstrategi.pdf. [1]] notes that integration between electronic health records (EHR) systems has a high priority. A prerequisite for real integration and semantic interoperability is agreement of the data content and the information models. The National Board of Health is working on a common model for EHR, ...

Tópico(s): Business Process Modeling and Analysis

2004 - Elsevier BV | International Journal of Medical Informatics

Artigo Revisado por pares

Li-Zhi Huang, Hans Christian Bruun Hansen, Morten J. Bjerrum,

Nitroaromatic compounds are substantial hazard to the environment and to the supply of clean drinking water. We report here the successful reduction of nitroaromatic compounds by use of iron oxide coated electrodes, and demonstrate that single sheet iron oxides formed from layered iron(II)-iron(III) hydroxides have unusual electrocatalytic reactivity. Electrodes were produced by coating of single sheet iron oxides on indium tin oxide electrodes. A reduction current density of 10 to 30μAcm(-2) was ...

Tópico(s): Advanced Photocatalysis Techniques

2015 - Elsevier BV | Journal of Hazardous Materials

Artigo Acesso aberto Revisado por pares

Josefine Tratwal, Anders Bruun Mathiasen, Morten Juhl, Sonja Kim Brorsen, Jens Kastrup, Annette Ekblond,

Stimulation of mesenchymal stromal cells and adipose tissue-derived stromal cells (ASCs) with vascular endothelial growth factor (VEGF) has been used in multiple animal studies and clinical trials for regenerative purposes. VEGF stimulation is believed to promote angiogenesis and VEGF stimulation is usually performed under serum deprivation. Potential regenerative molecular mechanisms are numerous and the role of contributing factors is uncertain. The aim of the current study was to investigate the ...

Tópico(s): Periodontal Regeneration and Treatments

2015 - BioMed Central | Stem Cell Research & Therapy

Artigo Revisado por pares

Anne C. Torbergsen, Leiv Otto Watne, Frede Frihagen, Torgeir Bruun Wyller, Morten Mowé,

Background and aim Hip fracture patients are at great risk of malnutrition, but documentation of the effect of nutrition supplementation in this group is sparse and inconclusive. The aim of this study was to examine if personalized nutrition advice combined with vitamin K1, Ca and vitamin D could improve bone turnover 4 months after hip fracture. Design This is a preplanned sub study of a randomized controlled trial of orthogeriatric care. The intervention group received orthogeriatric care, including ...

Tópico(s): Cardiac, Anesthesia and Surgical Outcomes

2018 - Elsevier BV | Clinical Nutrition ESPEN

Carta Acesso aberto Revisado por pares

Maj‐Brit Nørregaard Kjær, Tine Sylvest Meyhoff, Praleene Sivapalan, Anders Granholm, Peter Buhl Hjortrup, Martin Bruun Madsen, Morten Hylander Møller, Ingrid Egerod, Jørn Wetterslev, Theis Lange, Maria Cronhjort, Jon Henrik Laake, Stephan M. Jakob, Marek Nalos, Marlies Ostermann, Doug W Gould, Maurizio Cecconi, Manu L. N. G. Malbrain, Christian Ahlstedt, Louise Bendix Kiel, Morten H. Bestle, Lars Nebrich, Thomas Hildebrandt, Lene Russell, Marianne Vang, Michael L. Rasmussen, Christoffer Sølling, Anne Craveiro Brøchner, Mette Krag, Carmen A. Pfortmueller, Miroslav Kříž, Martin Siegemund, Giovanni Albano, Søren Rosborg Aagaard, Henning Bundgaard, Vera Crone, Sine Wichmann, Bror Johnstad, Yvonne Karin Martin, Philipp Seidel, Johan Mårtensson, Jacob Hollenberg, Mats Wistrand, Abele Donati, Enrico Barbara, Thomas Karvunidis, Alexa Hollinger, Andrea Carsetti, Nuttha Lumlertgul, Eva Joelsson‐Alm, Nikolas Lambiris, Tayyba Naz Aslam, Fredrik Femtehjell Friberg, Gitte Kingo Vesterlund, Camilla Bekker Mortensen, Stine Rom Vestergaard, Sidsel Fjordbak Caspersen, Diana Bertelsen Jensen, Morten Borup, Bodil Steen Rasmussen, Anders Perner,

To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conservative versus Liberal Approach to Fluid Therapy in Septic Shock in Intensive Care (CLASSIC) trial.

Tópico(s): Electrolyte and hormonal disorders

2023 - Springer Science+Business Media | Intensive Care Medicine

Artigo Acesso aberto Revisado por pares

Dennis Boye Larsen, Laila Bendix, Karin Abeler, Kristian Kjær Petersen, Michael Sprehn, Karin Due Bruun, Morten Rune Blichfeldt‐Eckhardt, Henrik Bjarke Vægter,

Abstract Objectives Sleep disturbances are increasingly recognized as a major part of chronic pain pathology. Obstructive sleep apnea (OSA) is a common occurrence in patients with chronic pain attending specialized pain clinics, yet its prevalence remains unclear. Using screening tools such as the Berlin and STOP-BANG questionnaires may aid in early identification of OSA and improve clinical care. This study i) examined the frequency of OSA based on objective sleep monitoring in patients with high- ...

Tópico(s): Sleep and Wakefulness Research

2021 - Elsevier BV | Scandinavian Journal of Pain

Artigo Revisado por pares

Christian Nøhr, Margit Kristensen, Stig Kjær Andersen, Søren Vingtoft, Søren Lippert, Knut Bernstein, Morten Bruun-Rasmussen,

In 1996 a national strategy for the development of electronic patient records (EPR) for the Danish hospitals and primary care was launched. An element in the strategy was to support a number of regional EPR development projects. The EPR-Observatory has in the two recent years collected data from the regional projects, dealing with the expectations in four areas: 1) Impact on organisational issues, 2) Benefits of EPR, 3) Integration of EPR with other information systems and 4) security aspects of ...

Tópico(s): Green IT and Sustainability

2001 - IOS Press | Studies in health technology and informatics

Artigo Acesso aberto Revisado por pares

Vibe Maria Laden Nielsen, Torben Anders Kløjgård, Henrik H. Bruun, Morten Breinholt Søvsø, Erika Frischknecht Christensen,

Objectives To examine the severity and progression of acute illness or injury in children using vital signs obtained during ambulance transport and categorised according to a paediatric triage model. Design A population-based historical cohort study using data from prehospital patient medical records linked to a national civil registration database. Setting Emergency medical services providing ground-level transport in a mixed urban–rural region with three hospitals in Denmark. Participants 25 039 ...

Tópico(s): Cardiac Arrest and Resuscitation

2020 - BMJ | BMJ Open

Artigo Revisado por pares

John Dr æby-Kristiansen, Michael Garsaae, Morten Bruun, Kristen Hansen,

From 1974 to 1977 we treated 96 patients for grade 2 or 3 cervical intraepithelial neoplasia with cryotherapy. They were monitored for 10 to 14 years with an attendance rate of 98%. Treatment resulted in cure in 92%. Nine patients had persisting lesions, and three patients had a recurrent lesion. The last recurrence was diagnosed 6.7 years after cryotherapy.

Tópico(s): Tumors and Oncological Cases

1991 - Elsevier BV | American Journal of Obstetrics and Gynecology

Revisão Acesso aberto Revisado por pares

Rustam Al‐Shahi Salman, Jacqueline Stephen, Jayne F. Tierney, Steff Lewis, David E. Newby, Adrian Parry‐Jones, Phil White, Stuart J. Connolly, Oscar Benavente, Dar Dowlatshahi, Charlotte Cordonnier, Catherine M. Viscoli, Kevin N. Sheth, Hooman Kamel, Roland Veltkamp, Kristin T Larsen, Jeannette Hofmeijer, Henk Kerkhoff, Floris H.B.M. Schreuder, Ashkan Shoamanesh, Catharina J.M. Klijn, H. Bart van der Worp, Didier Klug, Barbara Casolla, Laurent Puy, Morgane Coffee, Grégory Kuchcinski, Julien Labreuche, Koen M. van Nieuwenhuizen, Ale Algra, Isabelle C. Van Gelder, L. Jaap Kappelle, Gabriël J.E. Rinkel, Roger E. G. Schutgens, Pooja Khatri, Robin Conwit, Guido J. Falcone, Jordan Elm, Craig S. Anderson, Lili Song, Jeyaraj Pandian, Robert G. Hart, Mukul Sharma, Hany Aref, Wadea Tarhuni, J. Martí Fàbregas, Hans‐Christoph Diener, Matthias Endres, Robin Lemmens, Sun U. Kwon, Byung‐Chul Lee, Sebastián Ameriso, Truman J. Milling, Scott E. Kasner, Robert Mikulík, Denis Xavier, Ronny Beer, Danilo Toni, Jens Eckstein, David Seiffge, José M. Ferro, Georgios Tsivgoulis, Sanjib Kumar Sharma, Chia Wei-Liou, Stefan H. Hohnloser, Aristeidis H. Katsanos, Jackie Bosch, Jeff S. Healey, John W. Eikelboom, Alexander V. Khaw, David J. Gladstone, Aleksandra Pikula, Shelagh B. Coutts, Eric E. Smith, Kenneth Butcher, Thalia S. Field, Laura Gioia, Christian Stapf, Omid Halse, Peter Ringleb, Christian Enzinger, Igor Sibon, Joan Montaner, Valeria Caso, Peter U. Heuschmann, Gregory Y.H. Lip, Walter E. Haefeli, Stefanie Debette, Martin Dennis, Torgeir Bruun Wyller, Ole Morten Rønning, Helle Eilertsen, Hege Ihle‐Hansen, Else Charlotte Sandset, Johanna Pennlert, Eva‐Lotta Glader, Christina Kruuse, Per Wester, Maria Carlsson, Elisabeth Forfang,

The safety and efficacy of oral anticoagulation for prevention of major adverse cardiovascular events in people with atrial fibrillation and spontaneous intracranial haemorrhage are uncertain. We planned to estimate the effects of starting versus avoiding oral anticoagulation in people with spontaneous intracranial haemorrhage and atrial fibrillation.

Tópico(s): Acute Ischemic Stroke Management

2023 - Elsevier BV | The Lancet Neurology

Artigo Revisado por pares

Jan Holm, Christian Schou, Linnéa Nygren Babol, Anders J. Lawaetz, Susanne W. Bruun, Morten Z. Hansen, Steen Ingemann Hansen,

The folate binding protein (FBP) regulates homeostasis and intracellular trafficking of folic acid, a vitamin of decisive importance in cell division and growth. We analyzed whether interrelationship between ligand binding and self-association of FBP plays a significant role in the physiology of folate binding.Self-association behavior of apo- and holo-FBP was addressed through size exclusion chromatography, SDS-PAGE, mass spectrometry, surface plasmon resonance and fluorescence spectroscopy.Especially ...

Tópico(s): Protein Structure and Dynamics

2011 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects

Artigo Revisado por pares

Lene Russell, Martin Bruun Madsen, Morten Dahl, Peter Kampmann, Anders Perner,

We assessed the value of standard biochemical coagulation parameters in predicting bleeding, thrombosis and mortality in adult Intensive Care Unit (ICU) patients with haematological malignancies.We screened all patients with acute leukaemia and myelodysplastic syndrome admitted to a university hospital ICU during 2008-2012. Data were obtained from the clinical chemistry laboratory database and patient files. We graded bleeding according to the World Health Organisation (WHO)-system within 24-h, within ...

Tópico(s): Clinical Laboratory Practices and Quality Control

2017 - Wiley | Acta Anaesthesiologica Scandinavica