John Stover, James E. Rosen, Maria Nadia Carvalho, Eline L. Korenromp, Howard S. Frıedman, Matthew Cogan, Bidia Deperthes,
When used correctly and consistently, the male condom offers triple protection from unintended pregnancy and the transmission of sexually transmitted infections (STIs) and human immunodeficiency virus (HIV). However, with health funding levels stagnant or falling, it is important to understand the cost and health impact associated with prevention technologies. This study is one of the first to attempt to quantify the cost and combined health impact of condom use, as a means to prevent unwanted pregnancy ...
Tópico(s): COVID-19 Impact on Reproduction
2017 - Public Library of Science | PLoS ONE
Lukáš Krásný, Philip Bland, Jessica Burns, Nadia Carvalho Lima, Peter T. Harrison, Laura Pacini, Mark L. Elms, Jian Ning, Víctor G. Martínez, Yi-Ru Yu, Sophie E. Acton, Ping‐Chih Ho, Fernando Calvo, Amanda Swain, Beatrice A. Howard, Rachael Natrajan, Paul H. Huang,
SWATH-mass spectrometry (MS) enables accurate and reproducible proteomic profiling in multiple model organisms including the mouse. Here we present a comprehensive mouse reference spectral library (MouseRefSWATH) that permits quantification of up to 10,597 proteins (62.2% of the mouse proteome) by SWATH-MS. We exploit MouseRefSWATH to develop an analytical pipeline for species-specific deconvolution of proteomic alterations in human tumour xenografts (XenoSWATH). This method overcomes the challenge ...
Tópico(s): Molecular Biology Techniques and Applications
2020 - The Company of Biologists | Disease Models & Mechanisms
João Graça, Sónia Goulart Cardoso, Fábio Rafael Augusto, Nádia Carvalho Nunes,
In light of increasing calls for environmental policies that reduce meat consumption and promote more plant-based diets (i.e. Meat Curtailment Policies, MCPs), this study aimed to increase knowledge on how consumers may react to these policies. Participants (N = 784) were randomly presented with a small real news piece about an actual law approval referring to a MCP, or assigned to a no-information control condition. The study measured a set of ideological and consumption variables, and support for ...
Tópico(s): Organic Food and Agriculture
2020 - Taylor & Francis | Environmental Communication
Laura Pacini, Andrew Jenks, Nadia Carvalho Lima, Paul H. Huang,
Lung cancer is the most common cause of cancer-related deaths globally. Genetic alterations, such as amplifications, mutations and translocations in the fibroblast growth factor receptor (FGFR) family have been found in non-small cell lung cancer (NSCLC) where they have a role in cancer initiation and progression. FGFR aberrations have also been identified as key compensatory bypass mechanisms of resistance to targeted therapy against mutant epidermal growth factor receptor (EGFR) and mutant Kirsten ...
Tópico(s): Lung Cancer Research Studies
2021 - Multidisciplinary Digital Publishing Institute | Cells
Nadia Carvalho Lima, Eliza Atkinson, Tom D. Bunney, Matilda Katan, Paul H. Huang,
Selective FGFR inhibitors such as infigratinib (BGJ398) and erdafitinib (JNJ-42756493) have been evaluated in clinical trials for cancers with FGFR3 molecular alterations, particularly in urothelial carcinoma patients. However, a substantial proportion of these patients (up to 50%) display intrinsic resistance to these drugs and receive minimal clinical benefit. There is thus an unmet need for alternative therapeutic strategies to overcome primary resistance to selective FGFR inhibitors. In this study, ...
Tópico(s): Epigenetics and DNA Methylation
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Nádia de Carvalho Vidal, Herbert de Sousa Barbosa, Silvana do Couto Jacob, Marco Aurélio Zezzi Arruda,
Genetically modified foods are a major concern around the world due to the lack of information concerning their safety and health effects. This work evaluates differences, at the proteomic level, between two types of crop samples: transgenic (MON810 event with the Cry1Ab gene, which confers resistance to insects) and non-transgenic maize flour commercialized in Brazil. The 2-D DIGE technique revealed 99 differentially expressed spots, which were collected in 2-D PAGE gels and identified via mass ...
Tópico(s): CRISPR and Genetic Engineering
2015 - Elsevier BV | Food Chemistry
Peter Jackson, David M. Evans, Mónica Trüninger, João Afonso Baptista, Nádia Carvalho Nunes,
Based on fieldwork in the UK and Portugal, this paper considers the relationships between cultural analyses of taste and the embodied activity of tasting. As part of a wider project on the multiple ontologies of 'freshness', the paper conceptualises taste as an emergent effect of tasting practices. Drawing on evidence from a series of 'tasting events' (where research participants were recorded shopping, cooking and eating a meal with friends and family), the paper explores the multiple dimensions of ...
Tópico(s): Geographies of human-animal interactions
2020 - Taylor & Francis | Social & Cultural Geography
Produção Nacional
Revisado por pares
Ana Camila Micheletti, Adilson Beatriz, Dênis Pires de Lima, N Honda, Cláudia Pessoa, Manoel Odorico de Moraes, Letícia V. Costa‐Lotufo, Hemerson Iury Ferreira Magalhães, Nádia Cristina Pereira Carvalho,
ANTIBIOTIC AND CYTOTOXIC ACTIVITIES.From the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin.The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications.Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB -435).From lichexanthone were obtained norlichexanthone, 3-O-methylnorlichexanthone, 3-O- ...
Tópico(s): Cancer Treatment and Pharmacology
2009 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
Marilene Rodrigues Chang, Nádia Cristina Pereira Carvalho, Ana Lúcia Lyrio de Oliveira, Paola M. Moncada, Bianca Aguiar de Moraes, M.D. Asensi,
Nosocomial infections (NI) result in considerably high mortality and morbidity rates, especially among pediatric patients. Considering current worldwide changes, information about the occurrence of pathogens and susceptibility tests are now seen as decisive for optimizing treatment. The purpose of this research was to determine the frequency of microorganisms, antimicrobial and genetic profiles, and risk factors associated with nosocomial infections in a teaching hospital in Campo Grande, Mato Grosso ...
Tópico(s): Streptococcal Infections and Treatments
2003 - Elsevier BV | The Brazilian Journal of Infectious Diseases
Produção Nacional
Revisado por pares
Nádia Giulian de Carvalho, Carolina Verônica Lino Novelli, Maria Francisca Colella‐Santos,
Resumo: Há consenso na literatura da importância do sistema auditivo para o desenvolvimento da linguagem oral e escrita. O Distúrbio do Processamento Auditivo refere-se à dificuldade no processamento de informações auditivas, não sendo devido à perda auditiva, nem ao déficit intelectual. O objetivo desta revisão sistemática da literatura foi analisar quais fatores ocorridos na infância e adolescência podem influenciar no processamento auditivo, não necessariamente sendo a causa ou consequência do ...
Tópico(s): Hearing Impairment and Communication
2015 - CEFAC Saúde e Educação | Revista CEFAC
Produção Nacional
Revisado por pares
Nathália Rodrigues de Almeida Kogawa, Eduardo José de Arruda, Ana Camila Micheletti, Maria de Fátima Cepa Matos, Lincoln Carlos Silva de Oliveira, Dênis Pires de Lima, Nádia Cristina Pereira Carvalho, Paola Dias de Oliveira, Marillin de Castro Cunha, Mariáh Ojeda, Adilson Beatriz,
This study involved detailed characterization of ozonated oils, including thermal analysis and investigation of antimicrobial activity and cytotoxicity.
Tópico(s): Chemical Thermodynamics and Molecular Structure
2015 - Royal Society of Chemistry | RSC Advances
Produção Nacional
Revisado por pares
Nádia Giulian de Carvalho, Thalita Ubiali, Maria Isabel Ramos do Amaral, Maria Francisca Colella‐Santos,
Central auditory processing screening in schoolchildren has led to debates in literature, both regarding the protocol to be used and the importance of actions aimed at prevention and promotion of auditory health. Defining effective screening procedures for central auditory processing is a challenge in Audiology.
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2018 - Elsevier BV | Brazilian Journal of Otorhinolaryngology
Produção Nacional
Revisado por pares
Carolina Lino Novelli, Nádia Giulian de Carvalho, Maria Francisca Colella‐Santos,
The auditory processing is related to certain skills such as speech recognition in noise. The HINT-Brazil test allows the measurement of the Speech/Noise ratio however there are no studies in the national literature that establish parameters for the child population.To analyze the performance of normal-hearing subjects aged 8-10 years old in tasks for speech recognition in noise using HINT test.Sixty schoolchildren were evaluated. They were between 8 and 10 years of age, of both genders, and had ...
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2017 - Elsevier BV | Brazilian Journal of Otorhinolaryngology
Produção Nacional
Revisado por pares
Nádia Giulian de Carvalho, Carolina Verônica Lino Novelli, Maria Francisca Colella‐Santos,
This study aimed to analyze the perception of speech in noise in children with poor school performance and to compare them with children with good school performance, considering gender, age and ear side as variables. The intelligibility of speech was evaluated in school children utilizing the Brazilian Hearing in Noise Test (HINT) in the situations of quiet (Q), Left ear competitive noise (NL), Right Ear Competitive Noise (NR), as well as the global average of other hearing situations, denominated ...
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2017 - Elsevier BV | International Journal of Pediatric Otorhinolaryngology
Produção Nacional
Revisado por pares
Alexandra A.P. Mansur, Anderson J. Caires, Sandhra M. Carvalho, Nádia S. V. Capanema, Isadora C. Carvalho, Herman S. Mansur,
Glioblastoma (GBM) is the utmost aggressive and lethal primary brain cancer, which has a poor prognosis and remains virtually incurable. Nanomedicine with emerging disruptive nanotechnology alternatives, including designed supramolecular nanohybrids has excellent potential as multimodal tools against cancer by combining nanomaterials, biomacromolecules, and drugs. Thus, we developed and constructed for the first time quantum dot-biopolymer-drug nanohybrids based on host-guest chemistry for simultaneous ...
Tópico(s): Nanoplatforms for cancer theranostics
2019 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Isabel Carvalho, Nadia Safia Chenouf, José Antônio Mainardi de Carvalho, Ana Paula Castro, Vanessa Silva, Rosa Capita, Carlos Alonso‐Calleja, Maria de Lurdes Enes Dapkevicius, Gilberto Igrejas, Cármen Torres, Patrícia Poeta,
Klebsiella pneumoniae is a major pathogen implicated in nosocomial infections. Extended-spectrum β-lactamase (ESBL)-producing K . pneumoniae isolates are a public health concern. We aim to characterize the type of β-lactamases and the associated resistance mechanisms in ESBL-producing K . pneumoniae isolates obtained from blood cultures in a Portuguese hospital, as well as to determine the circulating clones. Twenty-two cefotaxime/ceftazidime-resistant (CTX/CAZ R ) K . pneumoniae isolates were included in ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2021 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Paola Dias de Oliveira, Nathália de Almeida, Martin Conda‐Sheridan, Rafael do Prado Apparecido, Ana Camila Micheletti, Nádia Cristina Pereira Carvalho, Edson dos Anjos dos Santos, Maria Rita Marques, Eduardo José de Arruda, Gláucia Braz Alcantara, Lincoln Carlos Silva de Oliveira, Dênis Pires de Lima, Adilson Beatriz,
Neem ozonated oils showed excellent broad-spectrum antimicrobial activity against standard E. faecalis , clinical vancomycin resistant E. faecium , clinical multiresistant K. pneumoniae (KPC), and S. aureus (MRSA and standard).
Tópico(s): Antibiotic Use and Resistance
2017 - Royal Society of Chemistry | RSC Advances
Produção Nacional
Revisado por pares
Alexandra A.P. Mansur, Mayara Rodrigues Brandão de Paiva, Oliver Araújo Lacerda Cotta, Luciana M. Silva, Isadora C. Carvalho, Nádia S. V. Capanema, Sandhra M. Carvalho, É.A. Costa, Nelson R. Martin, Roselene Ecco, Beatriz Senra Álvares da Silva Santos, Sílvia Ligório Fialho, Zélia Inês Portela Lobato, Herman S. Mansur,
Tópico(s): Carbon and Quantum Dots Applications
2022 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Ricardo Fernandes Carvalho, Nádia Mamede José, Adriana L. S. Carvalho, Cleidiene Souza de Miranda, N. Thomas, Muhammed Hasan Aslan, Ahmet Yayuz Oral, Mehmet Özer, Süleyman Hikmet Çağlar,
... Cite Icon Cite Search Site Citation Ricardo F. Carvalho, Nadia M. Jose, Adriana L. S. Carvalho, Cleidiene S. Miranda, Natasha I. R. Thomas; Polyester ...
Tópico(s): Synthesis and properties of polymers
2011 - American Institute of Physics | AIP conference proceedings
Produção Nacional
Revisado por pares
Claúdio Joaquim Borba-Pinheiro, Mauro César Gurgel de Alencar Carvalho, Nádia Souza Lima da Silva, Jani Cléria Pereira Bezerra, Alexandre Janotta Drigo, Estélio Henrique Martin Dantas,
A osteoporose é uma doença crônica que atinge o esqueleto humano. OBJETIVO: Verificar os efeitos do treinamento resistido sobre a densidade mineral óssea (DMO), força muscular, equilíbrio e qualidade de vida em mulheres menopausadas em tratamento com alendronato. MÉTODOS: Participaram do estudo 16 voluntárias. Elas foram separadas em dois grupos: que praticaram o treino resistido (n = 9, 49,7 ± 4,2 idade) e que constituíram o grupo controle (n = 7, 53,8 ± 4,4 idade). Os instrumentos de avaliação seguintes ...
Tópico(s): Scoliosis diagnosis and treatment
2010 - Sociedade Brasileira de Medicina do Esporte | Revista Brasileira de Medicina do Esporte
Produção Nacional
Revisado por pares
Nadia Nedjah, Marcus Vinícius Carvalho da Silva, Luiza de Macedo Mourelle,
Network-on-chips (NoC) is considered the next generation of communication infrastructure in embedded systems, which are omnipresent in different environments, such as cars, cell phones, and digital cameras. In the platform-based design methodology, an application is implemented by a set of collaborating intellectual properties (IPs) blocks. The selection of the most suited set of IPs as well as their physical mapping onto the NoC infrastructure to implement efficiently the application at hand are ...
Tópico(s): Embedded Systems Design Techniques
2010 - Elsevier BV | Journal of Systems Architecture
Produção Nacional
Revisado por pares
Claúdio Joaquim Borba-Pinheiro, Mauro César Gurgel de Alencar Carvalho, Nádia Souza Lima da Silva, Alexandre Janotta Drigo, Jani Cléria Pereira Bezerra, Estélio Henrique Martin Dantas,
Background: The objective of this study was to determine the effects of different physical activity (PA) programs on bone density, balance and quality of life of postmenopausal women taking concomitant alendronate. A quasi-experimental study was conducted with 35 volunteers divided into four groups: practitioners of resistance training (RTG, n = 9, 49.8±4.2 years), judo (JUG, n = 11, 52.2±5.3 years), water aerobics (WAG, n = 8, 57.1±7.4 years) and the control group (CG, n = 7, 53.8±4.4 years). Methods: The following ...
Tópico(s): Body Composition Measurement Techniques
2010 - SAGE Publishing | Therapeutic Advances in Musculoskeletal Disease
Produção Nacional
Sílvia Mendes da Cunha, Janaína Castro Núñez Carvalho, Nádia de Moura Kolling, Cristiane Ribeiro da Silva, Christian Haag Kristensen,
déficits em habilidades sociais estão presentes entre os pacientes avaliados, mostrando-se mais evidentes nas habilidades de auto-afirmação,
Tópico(s): Behavioral Health and Interventions
2007 - | Revista Brasileira de Terapias Cognitivas
Produção Nacional
Revisado por pares
Wendel Coura‐Vital, Marcos José Marques, Rodolfo Cordeiro Giunchetti, Andréa Teixeira−Carvalho, Nádia das Dores Moreira, Juliana Vitoriano-Souza, Paula Melo de Abreu Vieira, Cláudia Martins Carneiro, Rodrigo Corrêa‐Oliveira, O. A. Martins‐Filho, Mariângela Carneiro, Alexandre Barbosa Reis,
Molecular analysis, serology and immunophenotyping for T lymphocytes and their subsets, B lymphocytes and monocytes were performed on dogs naturally infected with Leishmania infantum. Animals were categorised as asymptomatic dogs I (AD-I), with negative serology and positive molecular results, and asymptomatic dogs II (AD-II), with positive serology and positive molecular results, and these were compared to symptomatic dogs (SD) and control dogs (CD). AD-I exhibited immunophenotypic features similar ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2011 - Elsevier BV | The Veterinary Journal
Produção Nacional
Revisado por pares
Regina Célia Santos Mendonça, Ana Márcia Faria Morelli, José Antônio Marques Pereira, Márcia Maria de Carvalho, Nádia Lopes de Souza,
Escherichia coli O:157:H7 adhesion and potential to form biofilm on three different surfaces commonly used in the food industry was evaluated using probabilistic models; the surfaces tested were stainless steel 304 (SS304), poly(vinyl chloride) film covered with thick cloth (PVC1) and poly(vinyl chloride) film covered with thin cloth (PVC2). Using a Central Composite Rotational Design (CCRD), the effect of contact time (0 h, 7 h, 24 h, 41 h and 48 h) and temperature (12 °C, 17 °C, 28 °C, 39 °C and 44 °C) on ...
Tópico(s): Indoor Air Quality and Microbial Exposure
2011 - Elsevier BV | Food Control
Produção Nacional
Revisado por pares
Nadia Nedjah, Marcus Vinícius Carvalho da Silva, Luiza de Macedo Mourelle,
Network-on-chip (NoC) are considered the next generation of communication infrastructure in embedded systems. In the platform-based design methodology, an application is implemented by a set of collaborative intellectual property (IP) blocks. The selection of the most suited set of IPs as well as their physical mapping onto the NoC infrastructure to implement efficiently the application at hand are two hard combinatorial problems that occur during the synthesis process of Noc-based embedded system ...
Tópico(s): Embedded Systems Design Techniques
2011 - Elsevier BV | Expert Systems with Applications
Produção Nacional
Revisado por pares
Nádia Roque, Vitor Cavalcanti Carvalho,
Resumo Asteraceae é a maior família das angiospermas com ca. 24.000 espécies e 1600-1700 gêneros com distribuição cosmopolita. Calea L. contém aproximadamente 125 espécies que ocorrem em regiões tropicais e subtropicais do Novo Mundo, sendo que o maior número de espécies é registrado para o Brasil. O gênero é facilmente confundido com espécies de Aspilia e Wedelia. No entanto, Calea possui flores do raio pistiladas e pápus de páleas livres, enquanto em Aspilia as flores do raio são neutras e o pápus ...
Tópico(s): Plant Diversity and Evolution
2011 - Rio de Janeiro Botanical Garden Research Institute | Rodriguésia
Produção Nacional
Revisado por pares
Claúdio Joaquim Borba-Pinheiro, Alexandre Janotta Drigo, Mauro César Gurgel de Alencar Carvalho, Nádia Souza Lima da Silva, Estélio Henrique Martin Dantas,
Background: The aim of this study was to verify socioeconomic differences, nutrition, body balance and quality of life (QoL) in postmenopausal women with low bone mineral density (BMD) in two Amazonian communities. Methods: A total of 42 female volunteers participated in the study. The volunteers were separated into two groups: Villa ( n = 20; 53 ± 5.5 years) and City ( n = 22; 56 ± 7.9 years). The following evaluation instruments were used: dual energy X-ray absorptiometry (DXA); a socioeconomic questionnaire; ...
Tópico(s): Body Composition Measurement Techniques
2011 - SAGE Publishing | Therapeutic Advances in Musculoskeletal Disease
Nadia Pisanti, Alexandra M. Carvalho, Laurent Marsan, Marie-France Sagot,
We present in this paper an exact algorithm for motif extraction. Efficiency is achieved by means of an improvement in the algorithm and data structures that applies to the whole class of motif inference algorithms based on suffix trees. An average case complexity analysis shows a gain over the best known exact algorithm for motif extraction. A full implementation was developed and made available online. Experimental results show that the proposed algorithm is more than two times faster than the ...
Tópico(s): Genomics and Phylogenetic Studies
2006 - Springer Science+Business Media | Lecture notes in computer science
Pedro Pimentel‐Nunes, Nádia Gonçalves, Inês Boal‐Carvalho, Luís Pedro Afonso, Paula Lopes, Roberto Roncon‐Albuquerque, Rui Henrique, Luís Moreira‐Dias, Adelino Leite‐Moreira, Mário Dinis‐Ribeiro,
Abstract Background Toll‐like receptors ( TLR ) are essential for H elicobacter pylori ( HP ) recognition. Their role in the progression of gastric lesions leading to cancer is not established. Aim To evaluate for the first time in humans the expression of TLR 2, TLR 4, and TLR 5, as well as the expression of other related molecules in the entire sequence of gastric lesions. Methods Biopsy samples (n = 80, 48% HP +) from normal mucosa, HP gastritis, metaplasia, dysplasia or adenocarcinoma were obtained from 44 ...
Tópico(s): Immune Response and Inflammation
2012 - Wiley | Helicobacter